AP3D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Defects in this gene are a cause of a new type of Hermansky-Pudlak syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.45810791
2COPI coating of Golgi vesicle (GO:0048205)4.45810791
3planar cell polarity pathway involved in neural tube closure (GO:0090179)4.24082887
4adherens junction assembly (GO:0034333)4.06871622
5synaptic vesicle maturation (GO:0016188)3.98158506
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87607351
7cell-substrate adherens junction assembly (GO:0007045)3.85800754
8focal adhesion assembly (GO:0048041)3.85800754
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.82209307
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81524778
11semaphorin-plexin signaling pathway (GO:0071526)3.78943158
12cell-substrate junction assembly (GO:0007044)3.59554053
13locomotory exploration behavior (GO:0035641)3.55862847
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.54345310
15macroautophagy (GO:0016236)3.54080593
16layer formation in cerebral cortex (GO:0021819)3.52972019
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.47821376
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47472289
19basement membrane organization (GO:0071711)3.46181685
20cerebellar Purkinje cell layer development (GO:0021680)3.40429636
21sodium ion export (GO:0071436)3.39417421
22proline biosynthetic process (GO:0006561)3.35299595
23regulation of ARF protein signal transduction (GO:0032012)3.29754286
24epithelial cell-cell adhesion (GO:0090136)3.28364612
25cell-cell junction maintenance (GO:0045217)3.24103279
26activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.23452762
27apoptotic process involved in morphogenesis (GO:0060561)3.21796999
28regulation of glucose import in response to insulin stimulus (GO:2001273)3.19698265
29activation of Rac GTPase activity (GO:0032863)3.19558864
30hemidesmosome assembly (GO:0031581)3.14001276
31maternal placenta development (GO:0001893)3.13310087
32heterochromatin organization (GO:0070828)3.12885738
33activation of protein kinase A activity (GO:0034199)3.11880084
34regulation of translational fidelity (GO:0006450)3.09430333
35proline transport (GO:0015824)3.08034470
36response to pheromone (GO:0019236)3.05121192
37mitotic chromosome condensation (GO:0007076)3.03370430
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.01586065
39regulation of clathrin-mediated endocytosis (GO:2000369)3.01386747
40mannose metabolic process (GO:0006013)3.01212491
41cellular potassium ion homeostasis (GO:0030007)2.98473988
42positive regulation of nuclease activity (GO:0032075)2.97758353
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93447178
44convergent extension (GO:0060026)2.93159101
45DNA unwinding involved in DNA replication (GO:0006268)2.92300826
46synaptic vesicle exocytosis (GO:0016079)2.90535897
47negative regulation of cell size (GO:0045792)2.90305891
48negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89514065
49alanine transport (GO:0032328)2.88835903
50regulation of nucleobase-containing compound transport (GO:0032239)2.87731574
51regulation of synaptic vesicle exocytosis (GO:2000300)2.87166370
52regulation of RNA export from nucleus (GO:0046831)2.85427211
53barbed-end actin filament capping (GO:0051016)2.82533778
54regulation of NFAT protein import into nucleus (GO:0051532)2.82485335
55vesicle coating (GO:0006901)2.81035308
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78020513
57vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76856749
58skin morphogenesis (GO:0043589)2.76674100
59cell communication by electrical coupling (GO:0010644)2.75767520
60establishment of apical/basal cell polarity (GO:0035089)2.75498692
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73630037
62vesicle transport along microtubule (GO:0047496)2.72034932
63cellular protein complex localization (GO:0034629)2.69289278
64spliceosomal tri-snRNP complex assembly (GO:0000244)2.68918284
65plasma membrane repair (GO:0001778)2.66089818
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65934231
67endoplasmic reticulum unfolded protein response (GO:0030968)2.65228325
68positive regulation of synapse maturation (GO:0090129)2.64324724
69insulin-like growth factor receptor signaling pathway (GO:0048009)2.64289062
70protein complex localization (GO:0031503)2.64192628
71endothelial cell chemotaxis (GO:0035767)2.63978784
72regulation of nuclease activity (GO:0032069)2.63623278
73apoptotic cell clearance (GO:0043277)2.62057229
74glucocorticoid receptor signaling pathway (GO:0042921)2.60984098
75cellular response to epidermal growth factor stimulus (GO:0071364)2.60859758
76regulation of cholesterol homeostasis (GO:2000188)2.60212771
77negative regulation of erythrocyte differentiation (GO:0045647)2.59983645
78regulation of synapse structural plasticity (GO:0051823)2.59637591
79Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59610417
80cellular response to unfolded protein (GO:0034620)2.57744016
81dendrite morphogenesis (GO:0048813)2.57705027
82protein targeting to Golgi (GO:0000042)2.57312430
83positive regulation of vesicle fusion (GO:0031340)2.57234576
84insulin secretion (GO:0030073)2.56129549
85regulation of ARF GTPase activity (GO:0032312)2.56122889
86establishment of protein localization to Golgi (GO:0072600)2.54583282
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.53141347
88regulation of synaptic vesicle transport (GO:1902803)2.53070402
89neurotransmitter secretion (GO:0007269)2.51875999
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50872703
91negative regulation of cell killing (GO:0031342)2.50872703
92regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50819535
93protein retention in ER lumen (GO:0006621)2.50587164
94cortical actin cytoskeleton organization (GO:0030866)2.50283322
95synaptic vesicle endocytosis (GO:0048488)2.50229382
96neural tube development (GO:0021915)2.49081740
97positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.48891246
98glutamate secretion (GO:0014047)2.48749430
99neuromuscular process controlling balance (GO:0050885)2.48748147
100glucose 6-phosphate metabolic process (GO:0051156)2.47478190
101paraxial mesoderm development (GO:0048339)2.46045248
102protein targeting to plasma membrane (GO:0072661)2.45630524
103regulation of early endosome to late endosome transport (GO:2000641)2.45318740
104negative regulation of fatty acid transport (GO:2000192)2.45151600
105ER-nucleus signaling pathway (GO:0006984)2.45023604
106protein maturation by protein folding (GO:0022417)2.44469827
107L-alpha-amino acid transmembrane transport (GO:1902475)2.43257486
108exploration behavior (GO:0035640)2.43241658
109desmosome organization (GO:0002934)2.42519761
110actin filament bundle assembly (GO:0051017)2.42171060
111actin filament bundle organization (GO:0061572)2.42171060
112protein export from nucleus (GO:0006611)2.42148975
113NLS-bearing protein import into nucleus (GO:0006607)2.41792257
114regulation of establishment of planar polarity (GO:0090175)2.41273128
115mRNA stabilization (GO:0048255)2.39378495
116RNA stabilization (GO:0043489)2.39378495
117atrioventricular valve morphogenesis (GO:0003181)2.39362003
118branching involved in mammary gland duct morphogenesis (GO:0060444)2.39313419
119vocalization behavior (GO:0071625)2.39210217
120proline metabolic process (GO:0006560)2.39017698
121positive regulation of histone deacetylation (GO:0031065)2.38847798
122cellular response to topologically incorrect protein (GO:0035967)2.38754834
123pinocytosis (GO:0006907)2.38306745
124positive regulation of protein dephosphorylation (GO:0035307)2.37537511
125cerebellar Purkinje cell differentiation (GO:0021702)2.37170060
126peptidyl-lysine dimethylation (GO:0018027)2.36932029
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.36287765
128protein localization to microtubule (GO:0035372)2.35901048
129retrograde transport, vesicle recycling within Golgi (GO:0000301)2.35841635
130ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.35803416
131mitotic G1 DNA damage checkpoint (GO:0031571)2.35665835
132nucleosome disassembly (GO:0006337)2.35616863
133protein-DNA complex disassembly (GO:0032986)2.35616863
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35150148
135protein localization to endosome (GO:0036010)2.35026619
136regulation of p38MAPK cascade (GO:1900744)2.34127586
137positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34038393
138regulation of extracellular matrix disassembly (GO:0010715)2.33948290
139activation of MAPKKK activity (GO:0000185)2.33872429
140innervation (GO:0060384)2.33594791
141regulation of glutamate receptor signaling pathway (GO:1900449)2.33515967
142endocytic recycling (GO:0032456)2.33515943
143intracellular estrogen receptor signaling pathway (GO:0030520)2.33403477
144stress fiber assembly (GO:0043149)2.32697084
145nuclear pore complex assembly (GO:0051292)2.32292480
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30225167
147modulation by virus of host morphology or physiology (GO:0019048)2.30146862
148establishment of nucleus localization (GO:0040023)2.30028456
149mating behavior (GO:0007617)2.29446773
150glycine transport (GO:0015816)2.29069377
151cochlea morphogenesis (GO:0090103)2.29027406
152intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.28238109
153pentose-phosphate shunt (GO:0006098)2.28148532
154G1 DNA damage checkpoint (GO:0044783)2.28139756
155negative regulation of cytosolic calcium ion concentration (GO:0051481)2.27947734
156membrane depolarization during action potential (GO:0086010)2.27557699
157positive regulation of nitric-oxide synthase activity (GO:0051000)2.27425196
158clathrin coat assembly (GO:0048268)2.22630740
159regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.22519964
160positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.22034456
161neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.21617384
162positive regulation of glycogen biosynthetic process (GO:0045725)2.21200381
163stress granule assembly (GO:0034063)2.20216349
164positive regulation of p38MAPK cascade (GO:1900745)2.19735193
165G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.19213876
166cytoplasmic mRNA processing body assembly (GO:0033962)2.17321631
167suckling behavior (GO:0001967)2.16826190
168organelle transport along microtubule (GO:0072384)2.15981840
169response to endoplasmic reticulum stress (GO:0034976)2.14937245
170membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.14459904
171detection of calcium ion (GO:0005513)2.12967794
172cellular sodium ion homeostasis (GO:0006883)2.12493783
173positive regulation of fibroblast migration (GO:0010763)2.11745213
174antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.11032377
175potassium ion homeostasis (GO:0055075)2.09545602
176antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.09464915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.50004780
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.81408085
3MYC_22102868_ChIP-Seq_BL_Human2.52653858
4DROSHA_22980978_ChIP-Seq_HELA_Human2.50487289
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35376148
6VDR_21846776_ChIP-Seq_THP-1_Human2.32619942
7EZH2_22144423_ChIP-Seq_EOC_Human2.31677954
8E2F7_22180533_ChIP-Seq_HELA_Human2.27018939
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24652745
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14527908
11* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06928788
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06089689
13KDM2B_26808549_Chip-Seq_K562_Human2.03892104
14RARB_27405468_Chip-Seq_BRAIN_Mouse1.93886408
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88669302
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86467294
17KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85167770
18ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80966182
19KDM2B_26808549_Chip-Seq_DND41_Human1.80645507
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77362936
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74719222
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74243168
23* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.73876201
24* LXR_22292898_ChIP-Seq_THP-1_Human1.73157123
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69381637
26REST_21632747_ChIP-Seq_MESCs_Mouse1.68043250
27* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.66559333
28UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.63661446
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61642953
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59647700
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58372850
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57689959
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.57248587
34GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56292415
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.55289649
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51082395
37* TET1_21451524_ChIP-Seq_MESCs_Mouse1.49014927
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48877740
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47587480
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45793989
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45766317
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44827605
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.44208702
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43736674
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42922109
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.42374386
47ZNF263_19887448_ChIP-Seq_K562_Human1.42159550
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42042356
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41683512
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40814753
51CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40667021
52* REST_18959480_ChIP-ChIP_MESCs_Mouse1.40411018
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39826558
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39205972
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39005760
56TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38465068
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38422947
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36155655
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36155655
60* P68_20966046_ChIP-Seq_HELA_Human1.35877578
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33338191
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32595370
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31732749
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.31544032
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31237068
66* ATF3_27146783_Chip-Seq_COLON_Human1.31117100
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30914864
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30718128
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30688363
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30254238
71TCF7_22412390_ChIP-Seq_EML_Mouse1.29901148
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28826176
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.28801433
74* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28153599
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28070528
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25488884
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25333974
78TP53_22127205_ChIP-Seq_IMR90_Human1.25140803
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24865154
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.24587696
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24422680
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24089799
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23901253
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.23755637
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22133565
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20307849
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18975614
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18691697
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18510266
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18209770
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17701508
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17625135
93SPI1_23127762_ChIP-Seq_K562_Human1.17577621
94CREB1_26743006_Chip-Seq_LNCaP_Human1.17239609
95AHR_22903824_ChIP-Seq_MCF-7_Human1.16345449
96MYC_18555785_ChIP-Seq_MESCs_Mouse1.15901488
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15025473
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14953607
99CLOCK_20551151_ChIP-Seq_293T_Human1.13619545
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.13256154
101SMC4_20622854_ChIP-Seq_HELA_Human1.13090391
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.11764465
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11670604
104RACK7_27058665_Chip-Seq_MCF-7_Human1.11118811
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10941191
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10819136
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09497873
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.09286177
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08263493
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.08178032
111* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08040882
112TET1_21490601_ChIP-Seq_MESCs_Mouse1.07947214
113NCOR1_26117541_ChIP-Seq_K562_Human1.06359903
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06173895
115ZNF274_21170338_ChIP-Seq_K562_Hela1.05947720
116* AR_19668381_ChIP-Seq_PC3_Human1.05543566
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05056112
118JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04753265
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02668571
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.02355800
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00874360
122AR_21909140_ChIP-Seq_LNCAP_Human1.00642708
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00544543
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00494765
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99699103
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99548364
127VDR_24763502_ChIP-Seq_THP-1_Human0.99547693
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99073834
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98449219
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98168048
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97704063
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97349908
133KLF4_19829295_ChIP-Seq_ESCs_Human0.96916404
134XRN2_22483619_ChIP-Seq_HELA_Human0.96761296
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95750875
136* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95438496
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.95070537
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.94194533
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.94048519
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.94048519
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93611998
142* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93113878
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92940737
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92863929
145ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92295225
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.92273703
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92137682
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.92063847
149CTCF_27219007_Chip-Seq_Bcells_Human0.92004640
150NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91992901
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91706474
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91571267
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91504094
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90867815
155* MITF_21258399_ChIP-Seq_MELANOMA_Human0.90712863
156OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90161045
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90031514
158* TP63_22573176_ChIP-Seq_HFKS_Human0.89958271
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89303552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.33215399
2MP0004859_abnormal_synaptic_plasticity4.10796975
3MP0009780_abnormal_chondrocyte_physiolo3.40527680
4MP0003283_abnormal_digestive_organ3.38353462
5MP0002909_abnormal_adrenal_gland3.05531530
6MP0003705_abnormal_hypodermis_morpholog3.02885919
7MP0003183_abnormal_peptide_metabolism2.91597411
8MP0008961_abnormal_basal_metabolism2.71347439
9MP0004858_abnormal_nervous_system2.70028290
10MP0005409_darkened_coat_color2.62540125
11MP0005451_abnormal_body_composition2.54199931
12MP0002877_abnormal_melanocyte_morpholog2.50293321
13* MP0003172_abnormal_lysosome_physiology2.45749310
14MP0005058_abnormal_lysosome_morphology2.37349809
15MP0000013_abnormal_adipose_tissue2.22613113
16MP0004272_abnormal_basement_membrane2.19874581
17MP0000537_abnormal_urethra_morphology2.18009274
18* MP0003635_abnormal_synaptic_transmissio2.06784336
19MP0005670_abnormal_white_adipose2.01653529
20MP0010030_abnormal_orbit_morphology1.96146073
21MP0009840_abnormal_foam_cell1.88918909
22MP0003045_fibrosis1.88542112
23MP0003300_gastrointestinal_ulcer1.86914623
24MP0003453_abnormal_keratinocyte_physiol1.85707895
25MP0010386_abnormal_urinary_bladder1.82185633
26MP0001348_abnormal_lacrimal_gland1.81824339
27MP0004270_analgesia1.75906528
28MP0002249_abnormal_larynx_morphology1.74324285
29MP0003123_paternal_imprinting1.72296700
30MP0005076_abnormal_cell_differentiation1.72269391
31MP0000003_abnormal_adipose_tissue1.70322235
32MP0005257_abnormal_intraocular_pressure1.64608025
33MP0001730_embryonic_growth_arrest1.60169536
34MP0008260_abnormal_autophagy1.59641035
35MP0009672_abnormal_birth_weight1.59482200
36MP0002063_abnormal_learning/memory/cond1.59232188
37MP0002796_impaired_skin_barrier1.59045402
38MP0008438_abnormal_cutaneous_collagen1.56983317
39MP0010234_abnormal_vibrissa_follicle1.53775436
40MP0004233_abnormal_muscle_weight1.53720203
41MP0002653_abnormal_ependyma_morphology1.48647121
42MP0005623_abnormal_meninges_morphology1.47105327
43MP0002060_abnormal_skin_morphology1.44675128
44MP0004510_myositis1.43628636
45MP0002090_abnormal_vision1.40676649
46MP0002733_abnormal_thermal_nociception1.40189977
47MP0003122_maternal_imprinting1.38413984
48MP0004811_abnormal_neuron_physiology1.38222734
49MP0009046_muscle_twitch1.36878710
50MP0009379_abnormal_foot_pigmentation1.36618273
51MP0003329_amyloid_beta_deposits1.35599526
52MP0005023_abnormal_wound_healing1.35255785
53MP0000566_synostosis1.34428137
54MP0002693_abnormal_pancreas_physiology1.34163830
55MP0003303_peritoneal_inflammation1.33033887
56MP0001299_abnormal_eye_distance/1.30945438
57MP0009053_abnormal_anal_canal1.29018666
58MP0002234_abnormal_pharynx_morphology1.27510811
59MP0001944_abnormal_pancreas_morphology1.25429889
60* MP0002064_seizures1.24971247
61MP0003566_abnormal_cell_adhesion1.24288620
62MP0002184_abnormal_innervation1.23964892
63MP0005501_abnormal_skin_physiology1.23689893
64MP0002734_abnormal_mechanical_nocicepti1.23047995
65MP0000579_abnormal_nail_morphology1.21230593
66MP0003111_abnormal_nucleus_morphology1.20273951
67MP0004130_abnormal_muscle_cell1.19840068
68MP0005375_adipose_tissue_phenotype1.19250510
69MP0003879_abnormal_hair_cell1.19168927
70MP0002896_abnormal_bone_mineralization1.18157455
71MP0003942_abnormal_urinary_system1.15127237
72MP0002837_dystrophic_cardiac_calcinosis1.14910940
73MP0004264_abnormal_extraembryonic_tissu1.14300343
74MP0001849_ear_inflammation1.13237314
75MP0003091_abnormal_cell_migration1.12448201
76MP0001915_intracranial_hemorrhage1.12435940
77MP0003941_abnormal_skin_development1.11798606
78MP0001968_abnormal_touch/_nociception1.08676989
79MP0000767_abnormal_smooth_muscle1.07507388
80MP0002572_abnormal_emotion/affect_behav1.06806749
81MP0000350_abnormal_cell_proliferation1.05772073
82MP0005645_abnormal_hypothalamus_physiol1.05661525
83MP0000428_abnormal_craniofacial_morphol1.05221741
84MP0009745_abnormal_behavioral_response1.04052657
85MP0003787_abnormal_imprinting1.03359725
86MP0003115_abnormal_respiratory_system1.03335549
87MP0001970_abnormal_pain_threshold1.03207245
88MP0000762_abnormal_tongue_morphology1.02660036
89MP0009278_abnormal_bone_marrow1.02619649
90MP0002080_prenatal_lethality1.02042880
91MP0005621_abnormal_cell_physiology1.01114175
92MP0002078_abnormal_glucose_homeostasis1.01088138
93MP0005380_embryogenesis_phenotype1.00032273
94MP0001672_abnormal_embryogenesis/_devel1.00032273
95MP0003984_embryonic_growth_retardation0.99778123
96MP0002928_abnormal_bile_duct0.99770884
97MP0008569_lethality_at_weaning0.99254348
98MP0002085_abnormal_embryonic_tissue0.98244227
99MP0003385_abnormal_body_wall0.97762765
100MP0000747_muscle_weakness0.97745281
101MP0010630_abnormal_cardiac_muscle0.97176618
102MP0002697_abnormal_eye_size0.97076862
103MP0000955_abnormal_spinal_cord0.96552435
104MP0003279_aneurysm0.95840902
105MP0002735_abnormal_chemical_nociception0.95635704
106MP0000604_amyloidosis0.94639695
107MP0002086_abnormal_extraembryonic_tissu0.93090915
108MP0002088_abnormal_embryonic_growth/wei0.92290549
109MP0003634_abnormal_glial_cell0.91056494
110MP0000534_abnormal_ureter_morphology0.90621200
111MP0000462_abnormal_digestive_system0.89790863
112MP0000467_abnormal_esophagus_morphology0.89152596
113MP0010368_abnormal_lymphatic_system0.88388279
114MP0003959_abnormal_lean_body0.88163329
115MP0000759_abnormal_skeletal_muscle0.88150617
116MP0005535_abnormal_body_temperature0.87418635
117MP0010352_gastrointestinal_tract_polyps0.86870365
118MP0000858_altered_metastatic_potential0.86557826
119MP0003075_altered_response_to0.86151575
120MP0002084_abnormal_developmental_patter0.85481827
121MP0005508_abnormal_skeleton_morphology0.85358998
122MP0001440_abnormal_grooming_behavior0.84755700
123MP0001958_emphysema0.84170924
124MP0009384_cardiac_valve_regurgitation0.83480900
125MP0004957_abnormal_blastocyst_morpholog0.82353141
126MP0001501_abnormal_sleep_pattern0.82335247
127MP0002168_other_aberrant_phenotype0.82109564
128MP0001216_abnormal_epidermal_layer0.81490714
129MP0000432_abnormal_head_morphology0.81285390
130MP0005275_abnormal_skin_tensile0.81121128
131MP0002067_abnormal_sensory_capabilities0.81111523
132MP0001502_abnormal_circadian_rhythm0.80854770
133MP0004043_abnormal_pH_regulation0.80818913
134MP0000751_myopathy0.80780578
135MP0005448_abnormal_energy_balance0.80345139
136MP0002254_reproductive_system_inflammat0.79530815
137MP0004087_abnormal_muscle_fiber0.78420487
138MP0002736_abnormal_nociception_after0.78291599
139MP0003693_abnormal_embryo_hatching0.76749606
140MP0002116_abnormal_craniofacial_bone0.76242273
141MP0002069_abnormal_eating/drinking_beha0.76047390
142MP0002925_abnormal_cardiovascular_devel0.75530060
143MP0000778_abnormal_nervous_system0.75106831
144MP0005248_abnormal_Harderian_gland0.75065553
145MP0002092_abnormal_eye_morphology0.74461190
146MP0001697_abnormal_embryo_size0.74029272
147MP0002557_abnormal_social/conspecific_i0.73869328
148MP0004808_abnormal_hematopoietic_stem0.73696233
149MP0005503_abnormal_tendon_morphology0.73593119
150* MP0003633_abnormal_nervous_system0.73344594
151MP0005666_abnormal_adipose_tissue0.72807998
152MP0002089_abnormal_postnatal_growth/wei0.71110321
153MP0004197_abnormal_fetal_growth/weight/0.70898434
154MP0004947_skin_inflammation0.70078169
155MP0005220_abnormal_exocrine_pancreas0.69538577
156MP0002882_abnormal_neuron_morphology0.67866963
157* MP0002066_abnormal_motor_capabilities/c0.67281343
158MP0004185_abnormal_adipocyte_glucose0.66476316
159MP0002152_abnormal_brain_morphology0.66252644
160MP0000733_abnormal_muscle_development0.65026217
161MP0001756_abnormal_urination0.64710858
162MP0001765_abnormal_ion_homeostasis0.63647804
163MP0000678_abnormal_parathyroid_gland0.63593188
164* MP0003953_abnormal_hormone_level0.63327994
165MP0002269_muscular_atrophy0.60466698

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.74903339
2Hand muscle atrophy (HP:0009130)3.51962233
3Supranuclear gaze palsy (HP:0000605)3.42887138
4Visual hallucinations (HP:0002367)3.28054070
5Upper limb amyotrophy (HP:0009129)3.27565351
6Distal upper limb amyotrophy (HP:0007149)3.27565351
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.06163146
8Obstructive sleep apnea (HP:0002870)3.00636649
9Increased cerebral lipofuscin (HP:0011813)2.98650253
10Ulnar bowing (HP:0003031)2.89470659
11Broad face (HP:0000283)2.78455875
12Hyperacusis (HP:0010780)2.76068667
13Distal lower limb amyotrophy (HP:0008944)2.70136507
14Mucopolysacchariduria (HP:0008155)2.68837821
15Urinary glycosaminoglycan excretion (HP:0003541)2.68837821
16Achilles tendon contracture (HP:0001771)2.66410551
17Macroorchidism (HP:0000053)2.66289414
18Abnormality of polysaccharide metabolism (HP:0011012)2.64481823
19Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64481823
20Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64481823
21Abnormality of the lower motor neuron (HP:0002366)2.63234926
22Disproportionate tall stature (HP:0001519)2.62410757
23Vertebral compression fractures (HP:0002953)2.57527919
24Increased connective tissue (HP:0009025)2.54334820
25Dysostosis multiplex (HP:0000943)2.50986801
26Long toe (HP:0010511)2.47816002
27Long palpebral fissure (HP:0000637)2.45957221
28Fragile skin (HP:0001030)2.41922357
29Abnormality of the Achilles tendon (HP:0005109)2.40255554
30Shallow orbits (HP:0000586)2.35737576
31Focal seizures (HP:0007359)2.33055862
32Spinal rigidity (HP:0003306)2.29671912
33Lower limb amyotrophy (HP:0007210)2.29583474
34Flat acetabular roof (HP:0003180)2.27282352
35Postural instability (HP:0002172)2.25639831
36Neoplasm of the heart (HP:0100544)2.22818468
37Retinal atrophy (HP:0001105)2.22214453
38Aneurysm (HP:0002617)2.22137933
39Insomnia (HP:0100785)2.21826879
40Overriding aorta (HP:0002623)2.19573292
41Mitral regurgitation (HP:0001653)2.19206830
42Short nail (HP:0001799)2.18411834
43Abnormality of glycolipid metabolism (HP:0010969)2.18373998
44Abnormality of liposaccharide metabolism (HP:0010968)2.18373998
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.18373998
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.18372737
47Action tremor (HP:0002345)2.17007347
48Atrophic scars (HP:0001075)2.16310347
49Enlarged penis (HP:0000040)2.15160813
50Broad metatarsal (HP:0001783)2.15147155
51Cerebral inclusion bodies (HP:0100314)2.13215859
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.12069440
53Bowel diverticulosis (HP:0005222)2.12007296
54Hypercortisolism (HP:0001578)2.10907186
55Papilledema (HP:0001085)2.10156831
56Bundle branch block (HP:0011710)2.09920219
57Cervical subluxation (HP:0003308)2.08252497
58Depression (HP:0000716)2.07622474
59Pointed chin (HP:0000307)2.06957315
60Arnold-Chiari malformation (HP:0002308)2.05519070
61Global brain atrophy (HP:0002283)2.05500730
62Patellar dislocation (HP:0002999)2.04897841
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.04736425
64Advanced eruption of teeth (HP:0006288)2.03911566
65Blue sclerae (HP:0000592)2.03511928
66Abnormality of the thoracic spine (HP:0100711)2.01796274
67Distal lower limb muscle weakness (HP:0009053)1.98956021
68Biconcave vertebral bodies (HP:0004586)1.98932050
69Hemiplegia (HP:0002301)1.97370916
70Neuronal loss in central nervous system (HP:0002529)1.96081810
71Wormian bones (HP:0002645)1.95581272
72Natal tooth (HP:0000695)1.95557751
73Bladder diverticulum (HP:0000015)1.94610776
74Increased variability in muscle fiber diameter (HP:0003557)1.94202843
75Asymmetry of the thorax (HP:0001555)1.94069168
76Selective tooth agenesis (HP:0001592)1.92805188
77Ankle clonus (HP:0011448)1.91882146
78Apathy (HP:0000741)1.91820583
79Elfin facies (HP:0004428)1.91272984
80Bronchomalacia (HP:0002780)1.90569700
81Deep venous thrombosis (HP:0002625)1.90509777
82Resting tremor (HP:0002322)1.89257938
83Hyperparathyroidism (HP:0000843)1.89099804
84Dilatation of the ascending aorta (HP:0005111)1.88835342
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86813473
86Aortic aneurysm (HP:0004942)1.86321661
87Genu recurvatum (HP:0002816)1.85480820
88Trismus (HP:0000211)1.84398959
89Rapidly progressive (HP:0003678)1.84228948
90Back pain (HP:0003418)1.84103949
91Long eyelashes (HP:0000527)1.83550329
92Ankyloglossia (HP:0010296)1.82870412
93Hypoventilation (HP:0002791)1.81733411
94Vertebral arch anomaly (HP:0008438)1.81106449
95Nuclear cataract (HP:0100018)1.80519630
96Agitation (HP:0000713)1.79528522
97Congenital glaucoma (HP:0001087)1.79001560
98Abnormality of dentin (HP:0010299)1.78474824
99Increased nuchal translucency (HP:0010880)1.76910653
100Loss of speech (HP:0002371)1.76263114
101Severe short stature (HP:0003510)1.75810383
102Genetic anticipation (HP:0003743)1.75209999
103Turricephaly (HP:0000262)1.75102362
104Dysmetric saccades (HP:0000641)1.74773821
105Osteolytic defects of the hand bones (HP:0009699)1.74564958
106Osteolytic defects of the phalanges of the hand (HP:0009771)1.74564958
107EEG with generalized epileptiform discharges (HP:0011198)1.73849469
108Precocious puberty (HP:0000826)1.72770725
109Striae distensae (HP:0001065)1.72691975
110Asymmetric septal hypertrophy (HP:0001670)1.72274613
111Stridor (HP:0010307)1.71774156
112Abnormality of skeletal muscle fiber size (HP:0012084)1.71228486
113Lymphangioma (HP:0100764)1.71142145
114Thin bony cortex (HP:0002753)1.70258494
115Mildly elevated creatine phosphokinase (HP:0008180)1.68534050
116Diminished motivation (HP:0000745)1.68234433
117Premature skin wrinkling (HP:0100678)1.68075833
118Abnormality of the distal phalanges of the toes (HP:0010182)1.67570510
119Difficulty running (HP:0009046)1.67403031
120Hypsarrhythmia (HP:0002521)1.67194089
121Elbow flexion contracture (HP:0002987)1.67048604
122Flat cornea (HP:0007720)1.66388248
123Hyperinsulinemic hypoglycemia (HP:0000825)1.66307201
124Buphthalmos (HP:0000557)1.66304893
125Hyperextensible skin (HP:0000974)1.66199809
126Spinal muscular atrophy (HP:0007269)1.66087891
127Abnormal ossification of hand bones (HP:0005921)1.65785972
128Deep palmar crease (HP:0006191)1.65429382
129Postural tremor (HP:0002174)1.65264599
130Abnormality of oral frenula (HP:0000190)1.64987738
131Exostoses (HP:0100777)1.64737530
132Broad distal phalanx of finger (HP:0009836)1.64558462
133Thoracic kyphosis (HP:0002942)1.64419595
134Joint laxity (HP:0001388)1.64401300
135Impaired smooth pursuit (HP:0007772)1.64385865
136Partial duplication of thumb phalanx (HP:0009944)1.63667889
137Failure to thrive in infancy (HP:0001531)1.63636571
138Hyperglycemia (HP:0003074)1.62469024
139Hypercalcemia (HP:0003072)1.62320717
140Epileptiform EEG discharges (HP:0011182)1.61773836
141Mitral valve prolapse (HP:0001634)1.60725216
142Protrusio acetabuli (HP:0003179)1.60664488
143Frequent falls (HP:0002359)1.60022479
144Abnormality of ocular smooth pursuit (HP:0000617)1.59816451
145Absence seizures (HP:0002121)1.59799292
146Insulin-resistant diabetes mellitus (HP:0000831)1.59626344
147Deviation of the thumb (HP:0009603)1.58455055
148Spinal cord compression (HP:0002176)1.58243190
149Renal duplication (HP:0000075)1.58241876
150Syringomyelia (HP:0003396)1.58169807
151Spinal cord lesions (HP:0100561)1.58169807
152Arterial tortuosity (HP:0005116)1.58016964
153Increased CSF protein (HP:0002922)1.57446482
154Dislocated radial head (HP:0003083)1.57008764
155Premature rupture of membranes (HP:0001788)1.56929580
156Difficulty climbing stairs (HP:0003551)1.56328668
157Open mouth (HP:0000194)1.56302463
158Impaired social interactions (HP:0000735)1.56228938
159Abnormal social behavior (HP:0012433)1.56228938
160Thin ribs (HP:0000883)1.56180463
161Progressive sensorineural hearing impairment (HP:0000408)1.56088607
162Neurofibrillary tangles (HP:0002185)1.55493577
163Polygenic inheritance (HP:0010982)1.55265747
164Renovascular hypertension (HP:0100817)1.54939518
165Vascular tortuosity (HP:0004948)1.53827328
166Ankle contracture (HP:0006466)1.51301173
167Abnormality of calcium-phosphate metabolism (HP:0100530)1.50470118
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.50168889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.30018632
2SMG13.92465595
3MAP3K92.86944463
4PRKD32.77698436
5PKN22.72948830
6PRPF4B2.60599546
7RIPK12.51990303
8IRAK32.44266829
9PDGFRA2.28822194
10ERN12.26788923
11CAMK1G2.01690207
12TYRO31.94547506
13KSR21.92158701
14PAK61.86909575
15CAMKK11.80328491
16SCYL21.77564489
17NTRK31.76925803
18SIK21.74817050
19NTRK11.73625677
20EPHA21.71938289
21MARK11.68461110
22PTK61.64608119
23CAMK1D1.62943048
24ICK1.57827856
25RET1.57118790
26DDR21.54595506
27SIK11.51427335
28NME21.48912412
29MST1R1.48762005
30MINK11.48612340
31INSRR1.44398976
32PTK21.43403442
33MAP3K21.41622001
34RIPK41.36509286
35DAPK21.35873571
36MAP3K41.33755187
37STK381.32535492
38PAK41.32281035
39TTN1.32193991
40PAK31.27322491
41EEF2K1.26872200
42FGFR41.22279712
43PRKCH1.21866840
44NTRK21.20839016
45DMPK1.17107474
46FER1.15699933
47ALK1.12174976
48ARAF1.11801520
49MET1.10882055
50CDC42BPA1.09006257
51RPS6KA21.05017977
52KSR11.04433037
53FGFR20.99722351
54TAOK30.99554325
55LATS20.99415141
56PDGFRB0.98946091
57CDK120.96076913
58MAP3K100.90904196
59MTOR0.89971932
60BMX0.89906691
61SGK30.87216771
62TESK10.86788655
63JAK10.84279152
64TAOK20.83628153
65MAP2K30.83346181
66MAP3K80.82743951
67FGFR30.81110225
68MAP3K10.80889179
69BRAF0.80350874
70HIPK20.79325711
71PDK40.78988279
72PDK30.78988279
73CDK50.77566765
74MARK20.76108408
75CAMKK20.75951731
76PTK2B0.75099487
77TAOK10.74737619
78MAP2K10.72742453
79PDK10.68253541
80EPHB10.67584400
81CDK70.67214577
82PDPK10.65326653
83LMTK20.62939108
84CDK40.60277663
85MAP3K30.60167242
86EPHB20.59594357
87RPS6KC10.57833538
88RPS6KL10.57833538
89DYRK1B0.56790031
90FRK0.56363603
91PAK20.56251558
92PNCK0.56163474
93MAP3K110.55703519
94EPHA40.54485307
95LRRK20.52930969
96PDK20.52697306
97WNK10.51993049
98ILK0.50821654
99LATS10.49864170
100PRKD10.49480253
101MAP2K40.49410690
102JAK20.48442873
103PASK0.46834714
104MAP3K60.46187803
105PRKAA10.45842412
106MAP3K130.45727288
107CDK11A0.45650178
108MAP3K70.45358654
109MAPK110.45254026
110PRKG20.44872060
111FGFR10.44365581
112CDK90.44165460
113RPS6KB20.42861410
114PRKD20.42609785
115UHMK10.42597153
116CHEK10.42070731
117MOS0.42033940
118CDK150.41149987
119AKT20.41059653
120SIK30.40956965
121GRK50.40836887
122ERBB40.39275932
123SRC0.39267135
124STK110.39074665
125HCK0.38654439
126TBK10.37783605
127MAP2K20.37547089
128PRKCZ0.37174512
129FYN0.36461954
130FES0.36270131
131BRD40.35780127
132AURKA0.35439511
133IRAK20.34782162
134MAPK100.34774464
135RPS6KA60.34667761
136PRKCG0.34665025
137RPS6KA30.33754404
138EGFR0.33112005
139TTK0.32873216
140CDK180.32855123
141ROCK20.32357480
142NEK20.32286936
143BRSK10.32108895
144PHKG20.31155321
145CDK20.29522504
146PRKCI0.28035463
147CDK60.27926321
148CHEK20.27710139
149MAPK120.27683825

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.22648890
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16509028
3Notch signaling pathway_Homo sapiens_hsa043302.10538738
4Other glycan degradation_Homo sapiens_hsa005112.01446736
5Type II diabetes mellitus_Homo sapiens_hsa049301.98858709
6Insulin secretion_Homo sapiens_hsa049111.92732466
7Prion diseases_Homo sapiens_hsa050201.85049907
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71476629
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.65945173
10Thyroid cancer_Homo sapiens_hsa052161.58929606
11Acute myeloid leukemia_Homo sapiens_hsa052211.53934127
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.52849621
13Circadian entrainment_Homo sapiens_hsa047131.42423455
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40843683
15mTOR signaling pathway_Homo sapiens_hsa041501.40422797
16Long-term potentiation_Homo sapiens_hsa047201.37638310
17Estrogen signaling pathway_Homo sapiens_hsa049151.36883993
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35151018
19Glioma_Homo sapiens_hsa052141.29163752
20GABAergic synapse_Homo sapiens_hsa047271.28492170
21Biosynthesis of amino acids_Homo sapiens_hsa012301.28159334
22ECM-receptor interaction_Homo sapiens_hsa045121.27881148
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.27536046
24Cholinergic synapse_Homo sapiens_hsa047251.26883824
25* Lysosome_Homo sapiens_hsa041421.26131559
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25111714
27Salivary secretion_Homo sapiens_hsa049701.24252720
28Gastric acid secretion_Homo sapiens_hsa049711.23386311
29Vitamin B6 metabolism_Homo sapiens_hsa007501.23148198
30Fructose and mannose metabolism_Homo sapiens_hsa000511.21990392
31Small cell lung cancer_Homo sapiens_hsa052221.21396535
32Olfactory transduction_Homo sapiens_hsa047401.20992926
33Galactose metabolism_Homo sapiens_hsa000521.20912038
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.19608142
35MicroRNAs in cancer_Homo sapiens_hsa052061.19531516
36Pentose phosphate pathway_Homo sapiens_hsa000301.19249607
37Dopaminergic synapse_Homo sapiens_hsa047281.18793440
38Prostate cancer_Homo sapiens_hsa052151.18602030
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16737829
40Renin secretion_Homo sapiens_hsa049241.15927505
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.15147945
42Lysine degradation_Homo sapiens_hsa003101.14794496
43Amphetamine addiction_Homo sapiens_hsa050311.14691733
44Morphine addiction_Homo sapiens_hsa050321.14253857
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14048945
46Vibrio cholerae infection_Homo sapiens_hsa051101.13079427
47GnRH signaling pathway_Homo sapiens_hsa049121.11837112
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11596256
49Pancreatic secretion_Homo sapiens_hsa049721.11233661
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06916584
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06502382
52Oxytocin signaling pathway_Homo sapiens_hsa049211.06361755
53Gap junction_Homo sapiens_hsa045401.06221656
54Cocaine addiction_Homo sapiens_hsa050301.05224682
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04518253
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04198924
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03872959
58Endometrial cancer_Homo sapiens_hsa052131.03309822
59Dorso-ventral axis formation_Homo sapiens_hsa043201.03203138
60Chronic myeloid leukemia_Homo sapiens_hsa052201.01664940
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01374593
62Glutamatergic synapse_Homo sapiens_hsa047241.00772041
63Nicotine addiction_Homo sapiens_hsa050330.98669505
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97634129
65VEGF signaling pathway_Homo sapiens_hsa043700.97602298
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96704921
67Collecting duct acid secretion_Homo sapiens_hsa049660.96001364
68Insulin signaling pathway_Homo sapiens_hsa049100.95926903
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95141213
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94697026
71Insulin resistance_Homo sapiens_hsa049310.94271583
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92788549
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.92332737
74Glucagon signaling pathway_Homo sapiens_hsa049220.91662507
75Colorectal cancer_Homo sapiens_hsa052100.90983871
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.89798489
77ErbB signaling pathway_Homo sapiens_hsa040120.88353105
78Non-small cell lung cancer_Homo sapiens_hsa052230.87775396
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86765273
80Endocytosis_Homo sapiens_hsa041440.86452806
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86042855
82Long-term depression_Homo sapiens_hsa047300.86038644
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85481332
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84010019
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83975560
86Proteoglycans in cancer_Homo sapiens_hsa052050.83704014
87Dilated cardiomyopathy_Homo sapiens_hsa054140.82049971
88Hippo signaling pathway_Homo sapiens_hsa043900.82026491
89Basal cell carcinoma_Homo sapiens_hsa052170.81719906
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81567857
91Inositol phosphate metabolism_Homo sapiens_hsa005620.80264230
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79825015
93Thyroid hormone synthesis_Homo sapiens_hsa049180.79450190
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77572243
95Prolactin signaling pathway_Homo sapiens_hsa049170.77439219
96Taste transduction_Homo sapiens_hsa047420.76171527
97cAMP signaling pathway_Homo sapiens_hsa040240.75888641
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.75716979
99Focal adhesion_Homo sapiens_hsa045100.75496950
100mRNA surveillance pathway_Homo sapiens_hsa030150.75487288
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75016906
102Melanogenesis_Homo sapiens_hsa049160.74884276
103Renal cell carcinoma_Homo sapiens_hsa052110.74595283
104Tight junction_Homo sapiens_hsa045300.74065988
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.73620607
106Choline metabolism in cancer_Homo sapiens_hsa052310.73341065
107Amoebiasis_Homo sapiens_hsa051460.70745333
108Sulfur relay system_Homo sapiens_hsa041220.70625426
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70509557
110Hepatitis C_Homo sapiens_hsa051600.69999326
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68526252
112Axon guidance_Homo sapiens_hsa043600.68408547
113Pathways in cancer_Homo sapiens_hsa052000.68321171
114AMPK signaling pathway_Homo sapiens_hsa041520.66931425
115Apoptosis_Homo sapiens_hsa042100.65437169
116Calcium signaling pathway_Homo sapiens_hsa040200.65161911
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.64717140
118Protein digestion and absorption_Homo sapiens_hsa049740.64469025
119HTLV-I infection_Homo sapiens_hsa051660.63018729
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62926536
121Melanoma_Homo sapiens_hsa052180.62585271
122Hepatitis B_Homo sapiens_hsa051610.61308532
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61008368
124MAPK signaling pathway_Homo sapiens_hsa040100.60744514
125Wnt signaling pathway_Homo sapiens_hsa043100.60398138
126Fatty acid biosynthesis_Homo sapiens_hsa000610.60110463
127Carbon metabolism_Homo sapiens_hsa012000.58794907
128N-Glycan biosynthesis_Homo sapiens_hsa005100.58653321
129Adherens junction_Homo sapiens_hsa045200.58308506
130Pancreatic cancer_Homo sapiens_hsa052120.57636879
131Platelet activation_Homo sapiens_hsa046110.57466788
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.56753780
133Rap1 signaling pathway_Homo sapiens_hsa040150.56605721
134Osteoclast differentiation_Homo sapiens_hsa043800.56414540
135Arginine biosynthesis_Homo sapiens_hsa002200.56032348
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55797912
137Salmonella infection_Homo sapiens_hsa051320.55440589
138Phagosome_Homo sapiens_hsa041450.55366333
139Serotonergic synapse_Homo sapiens_hsa047260.55300771
140Cell cycle_Homo sapiens_hsa041100.55166210
141Bladder cancer_Homo sapiens_hsa052190.54660455
142B cell receptor signaling pathway_Homo sapiens_hsa046620.54485250
143Chemokine signaling pathway_Homo sapiens_hsa040620.53151983
144HIF-1 signaling pathway_Homo sapiens_hsa040660.52727046

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