AP3S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the AP3 adaptor complex. This complex functions in the formation of subcellular vesicles budded from the Golgi body. Several related pseudogenes of this gene have been found. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.82329896
2killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.82329896
3neutrophil mediated immunity (GO:0002446)6.56636941
4negative regulation of phagocytosis (GO:0050765)6.13803574
5proteasome assembly (GO:0043248)5.82204464
6DNA deamination (GO:0045006)5.76582471
7defense response to fungus (GO:0050832)5.52385402
8modulation of growth of symbiont involved in interaction with host (GO:0044144)5.42449818
9regulation of growth of symbiont in host (GO:0044126)5.42449818
10negative regulation of growth of symbiont in host (GO:0044130)5.42449818
11negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.42449818
12myeloid leukocyte mediated immunity (GO:0002444)5.39158587
13response to fungus (GO:0009620)5.22033957
14disruption of cells of other organism (GO:0044364)5.12996077
15killing of cells of other organism (GO:0031640)5.12996077
16ribosomal small subunit assembly (GO:0000028)4.98088524
17cullin deneddylation (GO:0010388)4.93505239
18pentose-phosphate shunt (GO:0006098)4.86063920
19establishment of integrated proviral latency (GO:0075713)4.72712773
20protein deneddylation (GO:0000338)4.60577421
21respiratory burst (GO:0045730)4.57799363
22Arp2/3 complex-mediated actin nucleation (GO:0034314)4.54522548
23DNA double-strand break processing (GO:0000729)4.54452169
24protein neddylation (GO:0045116)4.53473331
25NADPH regeneration (GO:0006740)4.52221297
26reactive oxygen species biosynthetic process (GO:1903409)4.42242125
27ribonucleoprotein complex disassembly (GO:0032988)4.20817610
28establishment of viral latency (GO:0019043)4.12032578
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11069743
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.10806683
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02907589
32cellular response to zinc ion (GO:0071294)4.01747063
33cotranslational protein targeting to membrane (GO:0006613)3.99520453
34protein targeting to ER (GO:0045047)3.98882037
35organelle disassembly (GO:1903008)3.96375429
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.90771411
37leukocyte mediated cytotoxicity (GO:0001909)3.89925719
38signal peptide processing (GO:0006465)3.86876488
39protein localization to endoplasmic reticulum (GO:0070972)3.85649411
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.79854678
41CENP-A containing nucleosome assembly (GO:0034080)3.79358340
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77652979
43viral transcription (GO:0019083)3.75616571
44telomere maintenance via semi-conservative replication (GO:0032201)3.74363428
45neutrophil activation involved in immune response (GO:0002283)3.73084175
46ribosome assembly (GO:0042255)3.72667051
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70143983
48translational termination (GO:0006415)3.70021369
49DNA strand elongation involved in DNA replication (GO:0006271)3.69347806
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.68873973
51negative regulation of ligase activity (GO:0051352)3.68126775
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68126775
53COPI coating of Golgi vesicle (GO:0048205)3.63156803
54Golgi transport vesicle coating (GO:0048200)3.63156803
55chromatin remodeling at centromere (GO:0031055)3.61004038
56regulation of protein heterodimerization activity (GO:0043497)3.51845160
57DNA strand elongation (GO:0022616)3.49386984
58protein maturation by protein folding (GO:0022417)3.49023825
59regulation of cellular amino acid metabolic process (GO:0006521)3.46400145
60DNA damage response, detection of DNA damage (GO:0042769)3.45837892
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44141686
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44141686
637-methylguanosine mRNA capping (GO:0006370)3.42016238
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39322361
65sequestering of actin monomers (GO:0042989)3.39302995
66deoxyribonucleotide biosynthetic process (GO:0009263)3.38066613
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37020661
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.36811388
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35496697
70actin nucleation (GO:0045010)3.35024565
717-methylguanosine RNA capping (GO:0009452)3.31005804
72RNA capping (GO:0036260)3.31005804
73ATP synthesis coupled proton transport (GO:0015986)3.29978391
74energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29978391
75translational elongation (GO:0006414)3.28472744
76angiotensin maturation (GO:0002003)3.28256067
77glucose catabolic process (GO:0006007)3.27694507
78chaperone-mediated protein transport (GO:0072321)3.25415743
79formation of translation preinitiation complex (GO:0001731)3.24101628
80positive regulation of ligase activity (GO:0051351)3.23922261
81de novo protein folding (GO:0006458)3.23651523
82positive regulation of mitochondrial fission (GO:0090141)3.22731916
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21309833
84telomere maintenance via recombination (GO:0000722)3.19517750
85protein K11-linked ubiquitination (GO:0070979)3.18518635
86protein targeting to mitochondrion (GO:0006626)3.18517156
87termination of RNA polymerase III transcription (GO:0006386)3.18258059
88transcription elongation from RNA polymerase III promoter (GO:0006385)3.18258059
89sequestering of metal ion (GO:0051238)3.17240085
90mitotic metaphase plate congression (GO:0007080)3.15560617
91histone mRNA metabolic process (GO:0008334)3.14644066
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14520655
93nucleobase-containing small molecule interconversion (GO:0015949)3.13797787
94DNA catabolic process, exonucleolytic (GO:0000738)3.13111759
95regulation of ubiquitin-protein transferase activity (GO:0051438)3.10919898
96protein localization to mitochondrion (GO:0070585)3.09259899
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08280809
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08280809
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08280809
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07605206
101de novo posttranslational protein folding (GO:0051084)3.07592612
102pentose metabolic process (GO:0019321)3.07072235
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07034565
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07034565
105regulation of coenzyme metabolic process (GO:0051196)3.07021012
106regulation of cofactor metabolic process (GO:0051193)3.07021012
107regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.05106191
108ribosomal large subunit biogenesis (GO:0042273)2.99715896
109regulation of ligase activity (GO:0051340)2.99149835
110histone exchange (GO:0043486)2.98265240
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98043341
112signal transduction involved in cell cycle checkpoint (GO:0072395)2.97079529
113maturation of 5.8S rRNA (GO:0000460)2.96408694
114response to peptidoglycan (GO:0032494)2.96041808
115DNA replication initiation (GO:0006270)2.94744638
116rRNA modification (GO:0000154)2.93692896
117oxidative phosphorylation (GO:0006119)2.93137387
118signal transduction involved in DNA damage checkpoint (GO:0072422)2.92899999
119signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92899999
120platelet dense granule organization (GO:0060155)2.90362890
121DNA unwinding involved in DNA replication (GO:0006268)2.89899987
122spliceosomal snRNP assembly (GO:0000387)2.89704690
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88951307
124deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86844560
125cellular protein complex disassembly (GO:0043624)2.86253199
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85928794
127viral life cycle (GO:0019058)2.85680218
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85586532
129ribosomal small subunit biogenesis (GO:0042274)2.85084903
130mitotic recombination (GO:0006312)2.84792853
131establishment of protein localization to mitochondrion (GO:0072655)2.84692111
132membrane budding (GO:0006900)2.84574964
133macrophage differentiation (GO:0030225)2.83832590
134translational initiation (GO:0006413)2.83629858
135cell killing (GO:0001906)2.82955822
136necroptotic process (GO:0070266)2.82932131
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82096636
138respiratory electron transport chain (GO:0022904)2.81872728
139glucose 6-phosphate metabolic process (GO:0051156)2.81629327
140positive regulation of lamellipodium assembly (GO:0010592)2.80822799
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80298387
142peptidyl-histidine modification (GO:0018202)2.78086275
143metaphase plate congression (GO:0051310)2.77812114
144regulation of acyl-CoA biosynthetic process (GO:0050812)2.77473351
145positive regulation of actin filament depolymerization (GO:0030836)2.74534314
146DNA replication checkpoint (GO:0000076)2.74148892
147protein retention in ER lumen (GO:0006621)2.73581390
148electron transport chain (GO:0022900)2.72165111
149mitochondrial calcium ion transport (GO:0006851)2.70868062
150protein heterotetramerization (GO:0051290)2.70819494
151protein targeting to membrane (GO:0006612)2.69630972
152regulation of sulfur metabolic process (GO:0042762)2.69491273
153DNA replication-independent nucleosome assembly (GO:0006336)2.68108276
154DNA replication-independent nucleosome organization (GO:0034724)2.68108276
155mitotic spindle checkpoint (GO:0071174)2.66946472
156negative regulation of protein ubiquitination (GO:0031397)2.65061429
157translation (GO:0006412)2.64789951
158spindle checkpoint (GO:0031577)2.64430421
159protein-cofactor linkage (GO:0018065)2.63944731
160antigen processing and presentation of endogenous antigen (GO:0019883)2.63505684
161regulation of mitochondrial translation (GO:0070129)2.62780291
162DNA ligation (GO:0006266)2.62171223
163maturation of SSU-rRNA (GO:0030490)2.61943034
164GTP biosynthetic process (GO:0006183)2.61182026
165activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.60515597
166transcription elongation from RNA polymerase II promoter (GO:0006368)2.60375679
167guanosine-containing compound biosynthetic process (GO:1901070)2.59933395
168regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59542479
169hydrogen peroxide catabolic process (GO:0042744)2.58814010
170non-recombinational repair (GO:0000726)2.56307657
171double-strand break repair via nonhomologous end joining (GO:0006303)2.56307657
172regulation of cellular amine metabolic process (GO:0033238)2.56165695
173negative regulation of RNA splicing (GO:0033119)2.54849113
1742-deoxyribonucleotide biosynthetic process (GO:0009265)2.54797055
175deoxyribose phosphate biosynthetic process (GO:0046385)2.54797055
176telomere maintenance via telomere lengthening (GO:0010833)2.54174827
177antigen processing and presentation via MHC class Ib (GO:0002475)2.51916279
178heme biosynthetic process (GO:0006783)2.51071566
179protein complex disassembly (GO:0043241)2.50371086
180purine-containing compound salvage (GO:0043101)2.49648926
181L-fucose catabolic process (GO:0042355)2.48198742
182fucose catabolic process (GO:0019317)2.48198742
183L-fucose metabolic process (GO:0042354)2.48198742
184mast cell activation (GO:0045576)2.47698692
185cellular response to interferon-beta (GO:0035458)2.45219792
186positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43973564
187regulation of chemokine biosynthetic process (GO:0045073)2.43541506
188positive regulation of B cell differentiation (GO:0045579)2.41225873
189negative regulation of myeloid cell apoptotic process (GO:0033033)2.40324284
190production of molecular mediator involved in inflammatory response (GO:0002532)2.39919092
191pseudouridine synthesis (GO:0001522)2.39555037
192IMP metabolic process (GO:0046040)2.38438203
193antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.37840766
194response to interferon-beta (GO:0035456)2.37750405
195macromolecular complex disassembly (GO:0032984)2.37692501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.50345045
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11313670
3* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.25529344
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.16873559
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78221256
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71712616
7* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.71361183
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.68111923
9VDR_21846776_ChIP-Seq_THP-1_Human2.59182207
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58513023
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.56420849
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55198559
13TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.35939547
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.29463013
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28605920
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28156345
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.20471355
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20421332
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19831707
20SPI1_23547873_ChIP-Seq_NB4_Human2.16587629
21* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15308137
22* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15251747
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.12397462
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.12309242
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10083225
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06768388
27EWS_26573619_Chip-Seq_HEK293_Human2.05607807
28PADI4_21655091_ChIP-ChIP_MCF-7_Human2.04497197
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01126964
30MYC_22102868_ChIP-Seq_BL_Human1.99743779
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99649187
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99550137
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.98074045
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97006023
35* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.96898467
36DCP1A_22483619_ChIP-Seq_HELA_Human1.96494086
37* VDR_23849224_ChIP-Seq_CD4+_Human1.96291879
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94904343
39VDR_24763502_ChIP-Seq_THP-1_Human1.94009910
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93886889
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92873993
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91659700
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90902635
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88683888
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86770907
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86026707
47FUS_26573619_Chip-Seq_HEK293_Human1.84102567
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83361148
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81589857
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78379707
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78077867
52XRN2_22483619_ChIP-Seq_HELA_Human1.77857040
53SCL_19346495_ChIP-Seq_HPC-7_Human1.76734133
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73965360
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72581514
56TAF15_26573619_Chip-Seq_HEK293_Human1.71154419
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70558572
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69730481
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69289184
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.68459989
61* FOXP3_21729870_ChIP-Seq_TREG_Human1.65206210
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63648420
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.63017508
64GABP_19822575_ChIP-Seq_HepG2_Human1.62383731
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.62308769
66MYB_26560356_Chip-Seq_TH2_Human1.61084558
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.59380187
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58478457
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.58414347
70ELK1_19687146_ChIP-ChIP_HELA_Human1.57065589
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54928759
72* MYC_18940864_ChIP-ChIP_HL60_Human1.54140613
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53280942
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52631691
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.50717318
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49840698
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43116597
78GATA1_22025678_ChIP-Seq_K562_Human1.43051073
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40384255
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40357206
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.39503046
82* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38446448
83IGF1R_20145208_ChIP-Seq_DFB_Human1.38198713
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38043172
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37616335
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.36391728
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35773796
88TTF2_22483619_ChIP-Seq_HELA_Human1.34430779
89CIITA_25753668_ChIP-Seq_RAJI_Human1.33482406
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32729850
91AR_21909140_ChIP-Seq_LNCAP_Human1.31404581
92P300_19829295_ChIP-Seq_ESCs_Human1.30710595
93UTX_26944678_Chip-Seq_JUKART_Human1.30500054
94TFEB_21752829_ChIP-Seq_HELA_Human1.27709222
95MYB_26560356_Chip-Seq_TH1_Human1.27270160
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26838427
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24497401
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24355206
99MAF_26560356_Chip-Seq_TH1_Human1.23295458
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23151015
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22624836
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22395152
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21859687
104CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20349858
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19998017
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18042729
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.17512700
108SRF_21415370_ChIP-Seq_HL-1_Mouse1.16797913
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15160791
110VDR_22108803_ChIP-Seq_LS180_Human1.13996739
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13454870
112ZNF274_21170338_ChIP-Seq_K562_Hela1.13244143
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12880469
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12484125
115YY1_21170310_ChIP-Seq_MESCs_Mouse1.11791975
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10933261
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10623766
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10192967
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08334834
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07901494
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06251020
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06010928
123WT1_19549856_ChIP-ChIP_CCG9911_Human1.05987583
124PU_27001747_Chip-Seq_BMDM_Mouse1.01908712
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00601222
126TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00083309
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.99758552
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99460672
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97427818
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97085833
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96892540
132FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96638673
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96210358
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96019001
135BRD4_25478319_ChIP-Seq_HGPS_Human0.95531737
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95388002
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94100458
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93968274
139KDM5A_27292631_Chip-Seq_BREAST_Human0.93631720
140ELF5_23300383_ChIP-Seq_T47D_Human0.92358428
141STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91510869
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91450025
143* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90385447
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90152340
145TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89298549
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89247011
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88169528
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86667585
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83153209
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.82860564
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82033810
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81125328
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81125328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.49036203
2MP0003693_abnormal_embryo_hatching3.35731192
3MP0009697_abnormal_copulation3.33109762
4MP0003436_decreased_susceptibility_to3.26149103
5MP0001835_abnormal_antigen_presentation2.84042475
6MP0003724_increased_susceptibility_to2.80312874
7MP0002419_abnormal_innate_immunity2.77113750
8MP0002166_altered_tumor_susceptibility2.72243757
9MP0002396_abnormal_hematopoietic_system2.70099278
10MP0001529_abnormal_vocalization2.66509158
11MP0008932_abnormal_embryonic_tissue2.59899159
12MP0009785_altered_susceptibility_to2.58136726
13MP0003718_maternal_effect2.53975516
14MP0005025_abnormal_response_to2.42444409
15MP0003941_abnormal_skin_development2.42302298
16MP0003183_abnormal_peptide_metabolism2.41785993
17MP0001188_hyperpigmentation2.29333410
18MP0002006_tumorigenesis2.26792104
19MP0005464_abnormal_platelet_physiology2.26630507
20MP0005084_abnormal_gallbladder_morpholo2.19314052
21MP0000858_altered_metastatic_potential2.18228766
22MP0002148_abnormal_hypersensitivity_rea2.17621261
23MP0005000_abnormal_immune_tolerance2.17245048
24MP0005174_abnormal_tail_pigmentation2.14693608
25MP0000490_abnormal_crypts_of2.13277738
26MP0005397_hematopoietic_system_phenotyp2.13031554
27MP0001545_abnormal_hematopoietic_system2.13031554
28MP0003172_abnormal_lysosome_physiology2.12514294
29MP0006054_spinal_hemorrhage2.12478017
30MP0004272_abnormal_basement_membrane2.05816722
31MP0002420_abnormal_adaptive_immunity1.98099952
32MP0005671_abnormal_response_to1.97573661
33MP0002102_abnormal_ear_morphology1.96413056
34MP0004957_abnormal_blastocyst_morpholog1.95614477
35MP0001819_abnormal_immune_cell1.95306904
36MP0003011_delayed_dark_adaptation1.93322954
37MP0003786_premature_aging1.90953697
38MP0001542_abnormal_bone_strength1.89101134
39MP0002398_abnormal_bone_marrow1.88514270
40MP0001533_abnormal_skeleton_physiology1.88260408
41MP0009333_abnormal_splenocyte_physiolog1.87490141
42MP0000516_abnormal_urinary_system1.81829058
43MP0005367_renal/urinary_system_phenotyp1.81829058
44MP0005058_abnormal_lysosome_morphology1.80341525
45MP0000465_gastrointestinal_hemorrhage1.79152345
46MP0002452_abnormal_antigen_presenting1.75236372
47MP0006035_abnormal_mitochondrial_morpho1.74225905
48MP0000647_abnormal_sebaceous_gland1.73118793
49MP0010094_abnormal_chromosome_stability1.71379170
50MP0001293_anophthalmia1.69646931
51MP0001853_heart_inflammation1.69617856
52MP0000716_abnormal_immune_system1.69346613
53MP0002723_abnormal_immune_serum1.69210619
54MP0003111_abnormal_nucleus_morphology1.68620545
55MP0009379_abnormal_foot_pigmentation1.68157136
56MP0002234_abnormal_pharynx_morphology1.67251905
57MP0003950_abnormal_plasma_membrane1.66709206
58MP0010234_abnormal_vibrissa_follicle1.66519371
59MP0004808_abnormal_hematopoietic_stem1.66344238
60MP0000685_abnormal_immune_system1.65514594
61MP0001845_abnormal_inflammatory_respons1.64978794
62MP0003186_abnormal_redox_activity1.63847963
63MP0000343_altered_response_to1.62463580
64MP0003880_abnormal_central_pattern1.62064055
65MP0002405_respiratory_system_inflammati1.56595283
66MP0002429_abnormal_blood_cell1.56550116
67MP0002722_abnormal_immune_system1.55192128
68MP0002233_abnormal_nose_morphology1.54827183
69MP0003763_abnormal_thymus_physiology1.54521657
70MP0003656_abnormal_erythrocyte_physiolo1.51245477
71MP0006072_abnormal_retinal_apoptosis1.50401745
72MP0001800_abnormal_humoral_immune1.49334722
73MP0003077_abnormal_cell_cycle1.48727408
74MP0000689_abnormal_spleen_morphology1.47289317
75MP0005187_abnormal_penis_morphology1.46191307
76MP0005275_abnormal_skin_tensile1.46183279
77MP0010307_abnormal_tumor_latency1.45272102
78MP0003300_gastrointestinal_ulcer1.44390375
79MP0008789_abnormal_olfactory_epithelium1.44105148
80MP0003806_abnormal_nucleotide_metabolis1.42346796
81MP0002090_abnormal_vision1.42219237
82MP0003221_abnormal_cardiomyocyte_apopto1.39044877
83MP0010155_abnormal_intestine_physiology1.38528428
84MP0001873_stomach_inflammation1.36544782
85MP0002019_abnormal_tumor_incidence1.35511303
86MP0008469_abnormal_protein_level1.33745766
87MP0002736_abnormal_nociception_after1.30316474
88MP0002282_abnormal_trachea_morphology1.30057908
89MP0010352_gastrointestinal_tract_polyps1.25517006
90MP0002160_abnormal_reproductive_system1.25267158
91MP0003385_abnormal_body_wall1.25047377
92MP0005623_abnormal_meninges_morphology1.24241452
93MP0003937_abnormal_limbs/digits/tail_de1.20390285
94MP0003567_abnormal_fetal_cardiomyocyte1.20313182
95MP0005075_abnormal_melanosome_morpholog1.20181154
96MP0000703_abnormal_thymus_morphology1.19741828
97MP0006036_abnormal_mitochondrial_physio1.16611790
98MP0001663_abnormal_digestive_system1.16090051
99MP0000015_abnormal_ear_pigmentation1.15868700
100MP0001984_abnormal_olfaction1.15435745
101MP0008438_abnormal_cutaneous_collagen1.10958177
102MP0001790_abnormal_immune_system1.10788989
103MP0005387_immune_system_phenotype1.10788989
104MP0000049_abnormal_middle_ear1.10608577
105MP0002751_abnormal_autonomic_nervous1.10435531
106MP0001697_abnormal_embryo_size1.08963998
107MP0008057_abnormal_DNA_replication1.08665009
108MP0002877_abnormal_melanocyte_morpholog1.08110998
109MP0005220_abnormal_exocrine_pancreas1.08026752
110MP0000372_irregular_coat_pigmentation1.06609354
111MP0003448_altered_tumor_morphology1.06020382
112MP0005164_abnormal_response_to1.05090614
113MP0001177_atelectasis1.04934706
114MP0008007_abnormal_cellular_replicative1.04783782
115MP0004215_abnormal_myocardial_fiber1.03036780
116MP0000358_abnormal_cell_content/1.02477995
117MP0002970_abnormal_white_adipose1.01841646
118MP0001730_embryonic_growth_arrest0.99990192
119MP0002177_abnormal_outer_ear0.99745590
120MP0001879_abnormal_lymphatic_vessel0.99505895
121MP0003890_abnormal_embryonic-extraembry0.99280458
122MP0001286_abnormal_eye_development0.97374143
123MP0003755_abnormal_palate_morphology0.97291292
124MP0005253_abnormal_eye_physiology0.96986894
125MP0005501_abnormal_skin_physiology0.96881121
126MP0002095_abnormal_skin_pigmentation0.96390007
127MP0001881_abnormal_mammary_gland0.94148856
128MP0003866_abnormal_defecation0.92247015
129MP0008058_abnormal_DNA_repair0.91178997
130MP0005394_taste/olfaction_phenotype0.90680422
131MP0005499_abnormal_olfactory_system0.90680422
132MP0001299_abnormal_eye_distance/0.90585650
133MP0000427_abnormal_hair_cycle0.90456876
134MP0005503_abnormal_tendon_morphology0.89067788
135MP0001851_eye_inflammation0.84988419
136MP0000762_abnormal_tongue_morphology0.84900819
137MP0002933_joint_inflammation0.84174656
138MP0002084_abnormal_developmental_patter0.83998545
139MP0000313_abnormal_cell_death0.83842357
140MP0009763_increased_sensitivity_to0.83646649
141MP0005257_abnormal_intraocular_pressure0.82761325
142MP0002085_abnormal_embryonic_tissue0.81351353
143MP0005360_urolithiasis0.80802584
144MP0003075_altered_response_to0.80543758
145MP0002693_abnormal_pancreas_physiology0.79926309
146MP0005076_abnormal_cell_differentiation0.79827312
147MP0002971_abnormal_brown_adipose0.79578939
148MP0002210_abnormal_sex_determination0.79571014
149MP0003121_genomic_imprinting0.79076517
150MP0001672_abnormal_embryogenesis/_devel0.79000583
151MP0005380_embryogenesis_phenotype0.79000583
152MP0008873_increased_physiological_sensi0.78843608
153MP0005389_reproductive_system_phenotype0.78421749
154MP0003315_abnormal_perineum_morphology0.78285974
155MP0009250_abnormal_appendicular_skeleto0.77651107
156MP0003795_abnormal_bone_structure0.77178240
157MP0003123_paternal_imprinting0.76331613
158MP0005391_vision/eye_phenotype0.76267790
159MP0004782_abnormal_surfactant_physiolog0.75368228
160MP0001986_abnormal_taste_sensitivity0.75150640
161MP0002938_white_spotting0.74547623
162MP0000598_abnormal_liver_morphology0.72743282
163MP0005584_abnormal_enzyme/coenzyme_acti0.71258628
164MP0005390_skeleton_phenotype0.71230076
165MP0001727_abnormal_embryo_implantation0.71184216
166MP0000653_abnormal_sex_gland0.70908679
167MP0000350_abnormal_cell_proliferation0.70693094
168MP0003119_abnormal_digestive_system0.70554074
169MP0002080_prenatal_lethality0.70278678
170MP0001905_abnormal_dopamine_level0.70150175
171MP0002060_abnormal_skin_morphology0.70060603
172MP0005319_abnormal_enzyme/_coenzyme0.70047142
173MP0001764_abnormal_homeostasis0.69941532
174MP0010678_abnormal_skin_adnexa0.69766328
175MP0005193_abnormal_anterior_eye0.69407682
176MP0001340_abnormal_eyelid_morphology0.69391024
177MP0002089_abnormal_postnatal_growth/wei0.68806448
178MP0000249_abnormal_blood_vessel0.68700507
179MP0001243_abnormal_dermal_layer0.67244369
180MP0002998_abnormal_bone_remodeling0.66520370
181MP0001929_abnormal_gametogenesis0.66498617
182MP0003191_abnormal_cellular_cholesterol0.66093954
183MP0003252_abnormal_bile_duct0.65626496
184MP0002796_impaired_skin_barrier0.65305509

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.43616099
2Eczematoid dermatitis (HP:0000976)4.57028017
3Recurrent abscess formation (HP:0002722)4.42382396
4Abnormal number of erythroid precursors (HP:0012131)4.38168039
5Abnormality of cells of the erythroid lineage (HP:0012130)4.29770478
6Elevated erythrocyte sedimentation rate (HP:0003565)4.29139085
7Reduced antithrombin III activity (HP:0001976)4.22429221
8Acute necrotizing encephalopathy (HP:0006965)4.16296849
9Recurrent bacterial skin infections (HP:0005406)4.05690434
10Increased hepatocellular lipid droplets (HP:0006565)4.01409214
11Chronic obstructive pulmonary disease (HP:0006510)3.97059990
12Obstructive lung disease (HP:0006536)3.97059990
13Aplastic anemia (HP:0001915)3.73315715
14Acute encephalopathy (HP:0006846)3.70003513
15Abnormal mitochondria in muscle tissue (HP:0008316)3.66649215
16Progressive macrocephaly (HP:0004481)3.53992841
17Myositis (HP:0100614)3.49078354
18Mitochondrial inheritance (HP:0001427)3.48698795
19Type I transferrin isoform profile (HP:0003642)3.46911839
20Increased CSF lactate (HP:0002490)3.45783046
21Papilledema (HP:0001085)3.41487643
22Increased serum pyruvate (HP:0003542)3.39236506
23Recurrent gram-negative bacterial infections (HP:0005420)3.35342190
24Reticulocytopenia (HP:0001896)3.28062556
25Abnormality of glycolysis (HP:0004366)3.18799532
26Hepatocellular necrosis (HP:0001404)3.07723101
27Abnormal protein glycosylation (HP:0012346)3.07490090
28Abnormal glycosylation (HP:0012345)3.07490090
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.07490090
30Abnormal protein N-linked glycosylation (HP:0012347)3.07490090
31Abnormality of the prostate (HP:0008775)3.01438420
32Renal Fanconi syndrome (HP:0001994)3.01358309
33Petechiae (HP:0000967)2.95307754
34Cerebral edema (HP:0002181)2.85763379
35Abnormality of the lumbar spine (HP:0100712)2.84638649
36Chest pain (HP:0100749)2.84092443
37Vacuolated lymphocytes (HP:0001922)2.83715382
38Meningitis (HP:0001287)2.79057014
39Increased serum lactate (HP:0002151)2.78420281
40Mediastinal lymphadenopathy (HP:0100721)2.78256662
41Abnormality of the thoracic spine (HP:0100711)2.75847661
42Periodontitis (HP:0000704)2.74685958
43Thoracic kyphosis (HP:0002942)2.73629048
44Abnormality of B cell number (HP:0010975)2.72648937
45B lymphocytopenia (HP:0010976)2.72648937
46Pulmonary fibrosis (HP:0002206)2.66712988
47Posterior subcapsular cataract (HP:0007787)2.65141360
48Abnormality of T cell physiology (HP:0011840)2.59470926
49Lactic acidosis (HP:0003128)2.59261279
50Recurrent skin infections (HP:0001581)2.57812867
51IgM deficiency (HP:0002850)2.57019415
52Eosinophilia (HP:0001880)2.52982321
53Granulocytopenia (HP:0001913)2.49500627
54Thoracolumbar scoliosis (HP:0002944)2.48743158
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48613560
56Cortical dysplasia (HP:0002539)2.48508154
57Recurrent fungal infections (HP:0002841)2.47922997
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47059978
59Poor head control (HP:0002421)2.46936968
60Abnormality of macrophages (HP:0004311)2.44632942
61Chronic otitis media (HP:0000389)2.42912864
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42596308
63J-shaped sella turcica (HP:0002680)2.39043709
64Dysostosis multiplex (HP:0000943)2.38745786
65Hemoptysis (HP:0002105)2.32741093
66Retinal dysplasia (HP:0007973)2.31964557
67Recurrent viral infections (HP:0004429)2.30062310
68Exercise intolerance (HP:0003546)2.29342303
69Hypergammaglobulinemia (HP:0010702)2.28987084
70Abnormality of serum amino acid levels (HP:0003112)2.28916716
71Abnormality of the labia minora (HP:0012880)2.27981892
723-Methylglutaconic aciduria (HP:0003535)2.26799161
73Impaired platelet aggregation (HP:0003540)2.26439682
74Abnormal platelet function (HP:0011869)2.26439682
75Delayed gross motor development (HP:0002194)2.26237469
76Short tibia (HP:0005736)2.25230964
77Urinary glycosaminoglycan excretion (HP:0003541)2.23191921
78Mucopolysacchariduria (HP:0008155)2.23191921
79Short middle phalanx of the 5th finger (HP:0004220)2.21939175
80Abnormal lung lobation (HP:0002101)2.21760555
81Pallor (HP:0000980)2.21328802
82Bifid tongue (HP:0010297)2.20184459
83Microglossia (HP:0000171)2.19657886
84Multiple enchondromatosis (HP:0005701)2.19359160
85Medial flaring of the eyebrow (HP:0010747)2.18153519
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18091320
87Abnormality of alanine metabolism (HP:0010916)2.18091320
88Hyperalaninemia (HP:0003348)2.18091320
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17126995
90Metaphyseal dysplasia (HP:0100255)2.16086959
91Nausea (HP:0002018)2.14808324
92Epistaxis (HP:0000421)2.14207494
93Congenital, generalized hypertrichosis (HP:0004540)2.12856744
94Congenital primary aphakia (HP:0007707)2.12392066
95Gingivitis (HP:0000230)2.11820661
96Oral leukoplakia (HP:0002745)2.10171255
97Postnatal microcephaly (HP:0005484)2.09637282
98Delayed CNS myelination (HP:0002188)2.08806269
99Hypoplasia of the thymus (HP:0000778)2.07828630
100Pulmonary infiltrates (HP:0002113)2.06973819
101Nephrogenic diabetes insipidus (HP:0009806)2.06215290
102Sensory axonal neuropathy (HP:0003390)2.05375393
103Prolonged bleeding time (HP:0003010)2.04128546
104Microvesicular hepatic steatosis (HP:0001414)2.03242384
105Gait imbalance (HP:0002141)2.02781620
106Leukocytosis (HP:0001974)2.02442873
107Respiratory failure (HP:0002878)2.01703494
108Abnormality of methionine metabolism (HP:0010901)2.01625506
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.01367553
110Vasculitis (HP:0002633)2.01025770
111Degeneration of anterior horn cells (HP:0002398)2.00220464
112Abnormality of the anterior horn cell (HP:0006802)2.00220464
113Exertional dyspnea (HP:0002875)1.99621558
114Abnormality of the pleura (HP:0002103)1.99303500
115Hyperglycinemia (HP:0002154)1.99275837
116Gastrointestinal infarctions (HP:0005244)1.99072595
117Hepatic necrosis (HP:0002605)1.96390254
118Increased muscle lipid content (HP:0009058)1.96179921
119Neoplasm of the adrenal gland (HP:0100631)1.93668208
120Microretrognathia (HP:0000308)1.92961118
121Neutropenia (HP:0001875)1.91732371
122Orchitis (HP:0100796)1.91696271
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91397844
124Abnormality of polysaccharide metabolism (HP:0011012)1.91397844
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91397844
126Premature rupture of membranes (HP:0001788)1.91306419
127Macrocytic anemia (HP:0001972)1.90927845
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90901269
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90901269
130Median cleft lip (HP:0000161)1.90670129
131Neoplasm of the peripheral nervous system (HP:0100007)1.90268119
132Abnormality of T cells (HP:0002843)1.88586218
133Insidious onset (HP:0003587)1.88420307
134Termporal pattern (HP:0011008)1.88420307
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.87932153
136Polyphagia (HP:0002591)1.87536951
137Meckel diverticulum (HP:0002245)1.87439780
138Disinhibition (HP:0000734)1.87333417
139True hermaphroditism (HP:0010459)1.87082480
140Cellulitis (HP:0100658)1.86777181
141Genital tract atresia (HP:0001827)1.86697218
142Pancytopenia (HP:0001876)1.85804201
143Palpitations (HP:0001962)1.85465981
144Beaking of vertebral bodies (HP:0004568)1.85093980
145Hypoplastic pelvis (HP:0008839)1.84856304
146Urticaria (HP:0001025)1.84663510
147Poikiloderma (HP:0001029)1.82945115
148Neoplasm of the colon (HP:0100273)1.82411539
149Abnormal umbilical cord blood vessels (HP:0011403)1.82280693
150Single umbilical artery (HP:0001195)1.82280693
151Abnormality of the fetal cardiovascular system (HP:0010948)1.82280693
152Lipid accumulation in hepatocytes (HP:0006561)1.82019133
153Abnormality of eosinophils (HP:0001879)1.81726427
154Stenosis of the external auditory canal (HP:0000402)1.80781387
155Stomatitis (HP:0010280)1.80672048
156Leukodystrophy (HP:0002415)1.80419062
157Methylmalonic acidemia (HP:0002912)1.80173806
158Recurrent cutaneous fungal infections (HP:0011370)1.78545777
159Chronic mucocutaneous candidiasis (HP:0002728)1.78545777
160Lethargy (HP:0001254)1.78461219
161Abnormality of placental membranes (HP:0011409)1.77405645
162Amniotic constriction ring (HP:0009775)1.77405645
163Aplasia/hypoplasia of the uterus (HP:0008684)1.76898178
164Pancreatic fibrosis (HP:0100732)1.76087729
165Vaginal atresia (HP:0000148)1.76049708
166Abnormality of urine glucose concentration (HP:0011016)1.75907536
167Glycosuria (HP:0003076)1.75907536
168Optic disc pallor (HP:0000543)1.75891999
169Basal ganglia calcification (HP:0002135)1.75676254
170Generalized aminoaciduria (HP:0002909)1.75650619
171Abnormality of the ileum (HP:0001549)1.75496247
172Reduced subcutaneous adipose tissue (HP:0003758)1.75229995
173X-linked dominant inheritance (HP:0001423)1.75085630
174Atrophy/Degeneration involving motor neurons (HP:0007373)1.74304781
17511 pairs of ribs (HP:0000878)1.73993306
176Severe short stature (HP:0003510)1.73216054
177Increased neuronal autofluorescent lipopigment (HP:0002074)1.73081689
178CNS demyelination (HP:0007305)1.72648628
179Aplasia/Hypoplasia of the uvula (HP:0010293)1.72573924
180Abnormality of chromosome stability (HP:0003220)1.72200933
181Increased intramyocellular lipid droplets (HP:0012240)1.72199632
182Neuroendocrine neoplasm (HP:0100634)1.71134374
183Adrenal hypoplasia (HP:0000835)1.70553324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.24761842
2TRIM283.75960167
3SCYL23.65327313
4STK163.58067728
5EIF2AK33.35945322
6BCR3.24375055
7MAP3K122.91364845
8ERBB32.77865616
9IRAK42.77037591
10PIM22.70595559
11NEK12.53595036
12PBK2.43949610
13TEC2.43385784
14TAOK32.35390509
15ERN12.31426301
16TESK12.29428225
17NME22.24504994
18WEE12.19189103
19TESK22.17602456
20RIPK42.03835445
21BLK1.97587517
22TRIB31.86847471
23PKN21.86015588
24CAMKK21.82820347
25MST1R1.80301644
26CDC71.76503057
27SIK31.71959186
28FES1.71697293
29WNK31.68935818
30KDR1.67785574
31PLK41.61712339
32VRK11.59036346
33BTK1.56940399
34MAP2K71.53188458
35MAP4K11.52446859
36PLK31.51526947
37KIT1.50581989
38MAP4K21.46995904
39EIF2AK11.45960613
40ACVR1B1.42128429
41ZAP701.38392453
42CSNK1A1L1.37015462
43DAPK11.35932273
44BRSK21.34876407
45CSNK1G31.34228345
46PLK21.33902532
47VRK21.33527874
48LIMK11.32863048
49TBK11.29168832
50NUAK11.29010602
51MAP3K111.27382175
52BUB11.25952068
53BCKDK1.25741514
54CSNK1G21.24317986
55SYK1.20865829
56CCNB11.20280824
57LRRK21.20163559
58STK391.17223576
59RAF11.16866404
60DYRK31.16639829
61EEF2K1.16156298
62TTK1.15429738
63MAP3K41.15385051
64ABL21.15242258
65GRK61.14508151
66RPS6KA41.09424447
67TSSK61.08757503
68CSNK1G11.05024713
69CDK81.04886831
70TYK21.04862392
71MKNK21.00639837
72ZAK0.98718541
73MAP2K30.97850156
74MAPKAPK30.96843254
75PAK40.96455515
76NEK20.94027300
77ILK0.93562785
78BMPR1B0.93295571
79FLT30.91784282
80MYLK0.91347429
81ERBB40.89681644
82MINK10.84338450
83MET0.83521973
84BMPR20.83228666
85JAK30.82172350
86ARAF0.79666932
87MAPK40.79417137
88CDK40.77956084
89PIM10.77887068
90MAPK130.77627984
91ATR0.76205966
92LYN0.74581808
93CAMKK10.71473247
94ITK0.71286496
95MAP3K80.71262140
96FGFR10.70814781
97MAP3K60.70638224
98CDK70.69897939
99BRSK10.69764014
100EIF2AK20.67071924
101CDK140.66821486
102MAP3K50.66024271
103STK30.62939857
104NME10.62496304
105STK38L0.62176025
106IRAK30.61282674
107PRKCE0.61173322
108CDK180.59121224
109JAK20.56456101
110AURKB0.54090069
111MATK0.53999610
112TLK10.53688668
113LCK0.53263863
114PIK3CG0.53232898
115DYRK20.52560166
116CDK190.52427003
117WNK40.50132010
118TNIK0.48890007
119MAP3K10.48367221
120STK240.48150937
121RPS6KB20.47969175
122CASK0.47944078
123PASK0.47489388
124OXSR10.47447754
125IKBKE0.47191522
126BRAF0.46850717
127CDK60.46495137
128EPHA20.46392447
129MAP3K140.44720304
130CDK150.43986516
131CDK11A0.43376809
132MARK10.42467972
133SRPK10.41992232
134PRKCI0.41355602
135HCK0.40695864
136RPS6KB10.39799038
137EPHB20.39757622
138PAK10.38926433
139MAP3K100.38856954
140AURKA0.38654847
141TAOK10.38487314
142PLK10.37469794
143TRPM70.37008419
144CHEK20.36848541
145CSNK2A10.36483949
146RIPK10.36266593
147HIPK20.34805413
148MKNK10.34296483
149PRKCD0.33553427
150PINK10.33433063
151CSF1R0.32955675
152EPHA40.32614835
153STK100.31976688
154LATS20.31966449
155MAPK110.31434208
156TGFBR10.31397082
157PAK60.31396701
158CSNK2A20.31038960
159KSR10.29622534
160ADRBK10.28565339

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43547554
2Ribosome_Homo sapiens_hsa030103.57222555
3Protein export_Homo sapiens_hsa030603.55266260
4N-Glycan biosynthesis_Homo sapiens_hsa005102.70815641
5Proteasome_Homo sapiens_hsa030502.45604046
6Mismatch repair_Homo sapiens_hsa034302.41992189
7Basal transcription factors_Homo sapiens_hsa030222.30005380
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28315047
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.15570086
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14890946
11Pentose phosphate pathway_Homo sapiens_hsa000302.13959120
12Base excision repair_Homo sapiens_hsa034102.13624767
13Renin-angiotensin system_Homo sapiens_hsa046142.04517027
14Homologous recombination_Homo sapiens_hsa034401.96461733
15Leishmaniasis_Homo sapiens_hsa051401.89034378
16Sulfur metabolism_Homo sapiens_hsa009201.84653218
17Spliceosome_Homo sapiens_hsa030401.80435365
18Other glycan degradation_Homo sapiens_hsa005111.73596384
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68926036
20Pyrimidine metabolism_Homo sapiens_hsa002401.64466503
21Nucleotide excision repair_Homo sapiens_hsa034201.63149689
22Propanoate metabolism_Homo sapiens_hsa006401.61202301
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59318292
24Fatty acid elongation_Homo sapiens_hsa000621.58637121
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.51042516
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.50459145
27Steroid biosynthesis_Homo sapiens_hsa001001.50270121
28Antigen processing and presentation_Homo sapiens_hsa046121.42495618
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42337411
30Pyruvate metabolism_Homo sapiens_hsa006201.41283020
31Legionellosis_Homo sapiens_hsa051341.40355510
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40008141
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38099160
34Asthma_Homo sapiens_hsa053101.35542058
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35281828
36Sulfur relay system_Homo sapiens_hsa041221.33863875
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32825379
38Vitamin B6 metabolism_Homo sapiens_hsa007501.32794378
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25505847
40Cell cycle_Homo sapiens_hsa041101.23484649
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22919380
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17663715
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17492864
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16380177
45Thyroid cancer_Homo sapiens_hsa052161.16364400
46Phagosome_Homo sapiens_hsa041451.14806601
47Galactose metabolism_Homo sapiens_hsa000521.11865610
48RNA transport_Homo sapiens_hsa030131.11228020
49One carbon pool by folate_Homo sapiens_hsa006701.10990843
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10134489
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06724219
52Osteoclast differentiation_Homo sapiens_hsa043801.06491006
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04740279
54Shigellosis_Homo sapiens_hsa051311.04720331
55Non-homologous end-joining_Homo sapiens_hsa034500.99349926
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99296297
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97422525
58Pertussis_Homo sapiens_hsa051330.97361751
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95123561
60Tuberculosis_Homo sapiens_hsa051520.94188657
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93553060
62Herpes simplex infection_Homo sapiens_hsa051680.92991682
63Oocyte meiosis_Homo sapiens_hsa041140.92350093
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92062427
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91717097
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91476643
67* Lysosome_Homo sapiens_hsa041420.91409326
68Measles_Homo sapiens_hsa051620.91338777
69p53 signaling pathway_Homo sapiens_hsa041150.89015575
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88709665
71Apoptosis_Homo sapiens_hsa042100.88649915
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87851175
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87434782
74RNA polymerase_Homo sapiens_hsa030200.86670324
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86088279
76RNA degradation_Homo sapiens_hsa030180.84573973
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83981925
78Folate biosynthesis_Homo sapiens_hsa007900.83070701
79mRNA surveillance pathway_Homo sapiens_hsa030150.82506316
80Hepatitis B_Homo sapiens_hsa051610.80854163
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80528131
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79246647
83Acute myeloid leukemia_Homo sapiens_hsa052210.77978515
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.76562954
85Fanconi anemia pathway_Homo sapiens_hsa034600.75973289
86Metabolic pathways_Homo sapiens_hsa011000.75105161
87Salmonella infection_Homo sapiens_hsa051320.74479229
88Systemic lupus erythematosus_Homo sapiens_hsa053220.74380395
89Glutathione metabolism_Homo sapiens_hsa004800.74198538
90Phototransduction_Homo sapiens_hsa047440.73684505
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73437273
92Primary immunodeficiency_Homo sapiens_hsa053400.72546316
93Carbon metabolism_Homo sapiens_hsa012000.71904912
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69319776
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68329885
96Peroxisome_Homo sapiens_hsa041460.68103819
97Collecting duct acid secretion_Homo sapiens_hsa049660.68040454
98Olfactory transduction_Homo sapiens_hsa047400.66944890
99Starch and sucrose metabolism_Homo sapiens_hsa005000.65858531
100Arginine and proline metabolism_Homo sapiens_hsa003300.63478431
101Parkinsons disease_Homo sapiens_hsa050120.61867462
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.61361104
103Hematopoietic cell lineage_Homo sapiens_hsa046400.61019106
104Purine metabolism_Homo sapiens_hsa002300.60472848
105Toxoplasmosis_Homo sapiens_hsa051450.59596381
106Epstein-Barr virus infection_Homo sapiens_hsa051690.58267076
107Influenza A_Homo sapiens_hsa051640.57822120
108B cell receptor signaling pathway_Homo sapiens_hsa046620.57055365
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.53516375
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53512140
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53307966
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53025048
113Oxidative phosphorylation_Homo sapiens_hsa001900.52735835
114Caffeine metabolism_Homo sapiens_hsa002320.51540968
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.50571303
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49241420
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.48812394
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.48738876
119Chronic myeloid leukemia_Homo sapiens_hsa052200.48638812
120Biosynthesis of amino acids_Homo sapiens_hsa012300.47913584
121Selenocompound metabolism_Homo sapiens_hsa004500.46515471
122Alzheimers disease_Homo sapiens_hsa050100.44803901
123Regulation of autophagy_Homo sapiens_hsa041400.44209329
124VEGF signaling pathway_Homo sapiens_hsa043700.44004431
125Viral carcinogenesis_Homo sapiens_hsa052030.41955095
126Hippo signaling pathway_Homo sapiens_hsa043900.41437732
127Fatty acid metabolism_Homo sapiens_hsa012120.40903378
128Platelet activation_Homo sapiens_hsa046110.40774132
129Hedgehog signaling pathway_Homo sapiens_hsa043400.40506124
130TGF-beta signaling pathway_Homo sapiens_hsa043500.40183841
131Huntingtons disease_Homo sapiens_hsa050160.40039057
132TNF signaling pathway_Homo sapiens_hsa046680.38404880
133Pancreatic cancer_Homo sapiens_hsa052120.37201283
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37079111
135Malaria_Homo sapiens_hsa051440.35842990
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35644954
137Fat digestion and absorption_Homo sapiens_hsa049750.35616846
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35116383
139beta-Alanine metabolism_Homo sapiens_hsa004100.35005497
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34168419
141Vibrio cholerae infection_Homo sapiens_hsa051100.33374224
142Nicotine addiction_Homo sapiens_hsa050330.32487891
143Cardiac muscle contraction_Homo sapiens_hsa042600.28012083
144Ether lipid metabolism_Homo sapiens_hsa005650.26242372
145Wnt signaling pathway_Homo sapiens_hsa043100.25167147
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23055267
147Fatty acid degradation_Homo sapiens_hsa000710.18705064
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17970288
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17607894

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