AP3S2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.64701209
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52822977
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41012338
4synaptic vesicle exocytosis (GO:0016079)5.03385057
5cell migration in hindbrain (GO:0021535)4.67091225
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.59801659
7glutamate secretion (GO:0014047)4.46573210
8nucleobase catabolic process (GO:0046113)4.45952463
9regulation of synaptic vesicle exocytosis (GO:2000300)4.45589786
10negative regulation of microtubule polymerization (GO:0031115)4.37020950
11locomotory exploration behavior (GO:0035641)4.18511615
12layer formation in cerebral cortex (GO:0021819)4.04043271
13vocalization behavior (GO:0071625)3.98912789
14neurotransmitter secretion (GO:0007269)3.97641828
15regulation of synaptic vesicle transport (GO:1902803)3.95237973
16protein localization to synapse (GO:0035418)3.93757590
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.91144620
18proline transport (GO:0015824)3.87200648
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.84075330
20neuron cell-cell adhesion (GO:0007158)3.74161857
21establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.73595229
22mitochondrion transport along microtubule (GO:0047497)3.73595229
23peptidyl-arginine omega-N-methylation (GO:0035247)3.72532528
24regulation of glutamate receptor signaling pathway (GO:1900449)3.70643618
25negative regulation of organelle assembly (GO:1902116)3.61162748
26positive regulation of synapse maturation (GO:0090129)3.58831198
27establishment of mitochondrion localization (GO:0051654)3.57174055
28neurotransmitter catabolic process (GO:0042135)3.51870469
29pyrimidine nucleobase catabolic process (GO:0006208)3.49408205
30exploration behavior (GO:0035640)3.49358187
31cerebellar Purkinje cell differentiation (GO:0021702)3.45402917
32neuronal action potential propagation (GO:0019227)3.38652747
33water-soluble vitamin biosynthetic process (GO:0042364)3.34679918
34innervation (GO:0060384)3.34022604
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33524803
36peptidyl-arginine methylation (GO:0018216)3.32438432
37peptidyl-arginine N-methylation (GO:0035246)3.32438432
38dendritic spine morphogenesis (GO:0060997)3.30424603
39regulation of neuronal synaptic plasticity (GO:0048168)3.29279093
40histone arginine methylation (GO:0034969)3.24002652
41respiratory chain complex IV assembly (GO:0008535)3.22698829
42* axon cargo transport (GO:0008088)3.21179228
43neurotransmitter transport (GO:0006836)3.20160911
44response to pheromone (GO:0019236)3.19748798
45cell communication by electrical coupling (GO:0010644)3.18640465
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17825030
47regulation of synapse structural plasticity (GO:0051823)3.16155440
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15492062
49pre-miRNA processing (GO:0031054)3.13155324
50cerebellum development (GO:0021549)3.12993434
51synaptic vesicle endocytosis (GO:0048488)3.11945886
52neuromuscular process controlling posture (GO:0050884)3.10142509
53actin-myosin filament sliding (GO:0033275)3.09906418
54muscle filament sliding (GO:0030049)3.09906418
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08046777
56neuron recognition (GO:0008038)3.04382740
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03646981
58axonal fasciculation (GO:0007413)3.03201830
59cellular ketone body metabolic process (GO:0046950)3.01977397
60protein complex biogenesis (GO:0070271)2.99453376
61synaptic transmission, glutamatergic (GO:0035249)2.99168000
62glycine transport (GO:0015816)2.96917687
63gamma-aminobutyric acid transport (GO:0015812)2.95408537
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94553879
65dendrite morphogenesis (GO:0048813)2.92854891
66positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91299921
67regulation of long-term neuronal synaptic plasticity (GO:0048169)2.89936809
68neuromuscular synaptic transmission (GO:0007274)2.89024770
69organelle transport along microtubule (GO:0072384)2.88346304
70cytochrome complex assembly (GO:0017004)2.87849072
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83376675
72neuron-neuron synaptic transmission (GO:0007270)2.81500810
73ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.81123425
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80904999
75urinary tract smooth muscle contraction (GO:0014848)2.80478469
76long-term memory (GO:0007616)2.79818972
77regulation of neurotransmitter levels (GO:0001505)2.79171342
78regulation of neurotransmitter secretion (GO:0046928)2.79010471
79membrane depolarization during action potential (GO:0086010)2.78427237
80positive regulation of membrane potential (GO:0045838)2.77951330
81activation of protein kinase A activity (GO:0034199)2.77258831
82mitochondrial respiratory chain complex assembly (GO:0033108)2.77107840
83sarcoplasmic reticulum calcium ion transport (GO:0070296)2.75709561
84cerebellar Purkinje cell layer development (GO:0021680)2.74955875
85cellular potassium ion homeostasis (GO:0030007)2.73291718
86nonmotile primary cilium assembly (GO:0035058)2.73112959
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.71594597
88regulation of vesicle fusion (GO:0031338)2.71580674
89regulation of skeletal muscle contraction (GO:0014819)2.71346461
90regulation of synapse maturation (GO:0090128)2.71249147
91neurofilament cytoskeleton organization (GO:0060052)2.70528133
92postsynaptic membrane organization (GO:0001941)2.70215979
93behavioral response to nicotine (GO:0035095)2.69241621
94lipid particle organization (GO:0034389)2.68394874
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68393969
96regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67174190
97auditory behavior (GO:0031223)2.66134939
98membrane repolarization (GO:0086009)2.63989130
99neuromuscular process controlling balance (GO:0050885)2.63638588
100actin-mediated cell contraction (GO:0070252)2.62881422
101* establishment of synaptic vesicle localization (GO:0097480)2.62790280
102* synaptic vesicle transport (GO:0048489)2.62790280
103neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61999182
104electron transport chain (GO:0022900)2.61184577
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59666065
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.59666065
107NADH dehydrogenase complex assembly (GO:0010257)2.59666065
108respiratory electron transport chain (GO:0022904)2.58919847
109vesicle transport along microtubule (GO:0047496)2.58888075
110regulation of calcium ion-dependent exocytosis (GO:0017158)2.58369277
111ketone body metabolic process (GO:1902224)2.57852982
112adult heart development (GO:0007512)2.57643750
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57330319
114* establishment of vesicle localization (GO:0051650)2.55903238
115regulation of respiratory system process (GO:0044065)2.55560058
116sodium ion export (GO:0071436)2.55537090
117regulation of NFAT protein import into nucleus (GO:0051532)2.53892212
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.53556648
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.53289012
120regulation of neurotransmitter transport (GO:0051588)2.52725952
121hippocampus development (GO:0021766)2.52422964
122membrane hyperpolarization (GO:0060081)2.52198865
123creatine metabolic process (GO:0006600)2.52160048
124regulation of hexokinase activity (GO:1903299)2.52038781
125regulation of glucokinase activity (GO:0033131)2.52038781
126response to auditory stimulus (GO:0010996)2.51920252
127regulation of membrane repolarization (GO:0060306)2.51665086
128neuronal ion channel clustering (GO:0045161)2.50683342
129neuromuscular process (GO:0050905)2.50312908
130regulation of relaxation of muscle (GO:1901077)2.50288698
131mating behavior (GO:0007617)2.49538081
132positive regulation of potassium ion transmembrane transport (GO:1901381)2.49409731
133ATP synthesis coupled proton transport (GO:0015986)2.48454714
134energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48454714
135* cytoskeleton-dependent intracellular transport (GO:0030705)2.47447567
136glutamate receptor signaling pathway (GO:0007215)2.46593023
137potassium ion import (GO:0010107)2.45305108
138regulation of acyl-CoA biosynthetic process (GO:0050812)2.44591287
139C4-dicarboxylate transport (GO:0015740)2.44575870
140macroautophagy (GO:0016236)2.43580821
141fatty acid transmembrane transport (GO:1902001)2.41254846
142L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40794728
143ubiquinone metabolic process (GO:0006743)2.38603451
144L-serine metabolic process (GO:0006563)2.36935913
145amino acid salvage (GO:0043102)2.35242104
146L-methionine salvage (GO:0071267)2.35242104
147L-methionine biosynthetic process (GO:0071265)2.35242104
148regulation of cell communication by electrical coupling (GO:0010649)2.34575714
149retinal ganglion cell axon guidance (GO:0031290)2.31370261
150aspartate family amino acid catabolic process (GO:0009068)2.28462676
151positive regulation of mitochondrial fission (GO:0090141)2.28423801
152kynurenine metabolic process (GO:0070189)2.26937695
153response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.25853283
154regulation of cofactor metabolic process (GO:0051193)2.25030301
155regulation of coenzyme metabolic process (GO:0051196)2.25030301
156doxorubicin metabolic process (GO:0044598)2.21266191
157daunorubicin metabolic process (GO:0044597)2.21266191
158polyketide metabolic process (GO:0030638)2.21266191
159ubiquinone biosynthetic process (GO:0006744)2.21171760
160S-adenosylmethionine metabolic process (GO:0046500)2.19244037
161lysine metabolic process (GO:0006553)2.18371164
162lysine catabolic process (GO:0006554)2.18371164
163aldehyde catabolic process (GO:0046185)2.18264830
164branched-chain amino acid catabolic process (GO:0009083)2.16966083
165peptidyl-cysteine modification (GO:0018198)2.16452439
166myofibril assembly (GO:0030239)2.14640148
167presynaptic membrane organization (GO:0097090)2.14010038
168central nervous system myelination (GO:0022010)2.13602521
169axon ensheathment in central nervous system (GO:0032291)2.13602521
170muscle fiber development (GO:0048747)2.12811903
171tricarboxylic acid cycle (GO:0006099)2.12583034
172neurotransmitter metabolic process (GO:0042133)2.11919091
173chaperone-mediated protein transport (GO:0072321)2.11708677
174intraciliary transport (GO:0042073)2.11487498
175organelle disassembly (GO:1903008)2.11324782
176presynaptic membrane assembly (GO:0097105)2.09536733
177hydrogen ion transmembrane transport (GO:1902600)2.08050369
178regulation of sequestering of triglyceride (GO:0010889)2.08005747
179quinone metabolic process (GO:1901661)2.07376310
180protein localization to cilium (GO:0061512)2.07184062
181dicarboxylic acid catabolic process (GO:0043649)2.06803875
182response to inactivity (GO:0014854)2.06650055
183regulation of glycogen (starch) synthase activity (GO:2000465)2.06445627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49584738
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77919298
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.26969169
4REST_21632747_ChIP-Seq_MESCs_Mouse2.94492603
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.93104437
6REST_18959480_ChIP-ChIP_MESCs_Mouse2.76321319
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.53630293
8VDR_22108803_ChIP-Seq_LS180_Human2.43785651
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43337780
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41945063
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30940380
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30117583
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.30012825
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28922002
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22909020
16GBX2_23144817_ChIP-Seq_PC3_Human2.22545423
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11999122
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09927924
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09927924
20CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.07657280
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.07080112
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.02127493
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00883679
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.00214672
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.98885602
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98820040
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95909529
28DROSHA_22980978_ChIP-Seq_HELA_Human1.91358500
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86460181
30* GABP_17652178_ChIP-ChIP_JURKAT_Human1.85708777
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85662919
32FUS_26573619_Chip-Seq_HEK293_Human1.85493554
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84386202
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.80062513
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79932135
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78862812
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.77956674
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77184600
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73778849
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70002789
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67932493
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67389748
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66464504
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59930186
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57689071
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.56615140
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.56513969
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54624960
49TAF15_26573619_Chip-Seq_HEK293_Human1.53838103
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50050844
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.49816110
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45853497
53AR_21572438_ChIP-Seq_LNCaP_Human1.45701312
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.44779422
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42400628
56EWS_26573619_Chip-Seq_HEK293_Human1.42092848
57P300_19829295_ChIP-Seq_ESCs_Human1.41274151
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40328071
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40328071
60IRF1_19129219_ChIP-ChIP_H3396_Human1.36758343
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.35217225
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35087680
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.35072128
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34113537
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33039458
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32783203
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31095127
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30795989
69ER_23166858_ChIP-Seq_MCF-7_Human1.30434400
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30275002
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28971081
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.28881122
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28532398
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27600321
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26831091
76ZNF274_21170338_ChIP-Seq_K562_Hela1.23518642
77IGF1R_20145208_ChIP-Seq_DFB_Human1.22646672
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22505332
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.21911382
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21902398
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18453122
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18041774
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17546236
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17476272
85CIITA_25753668_ChIP-Seq_RAJI_Human1.17262306
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17050776
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16718611
88CTCF_27219007_Chip-Seq_Bcells_Human1.15109299
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14857813
90KDM2B_26808549_Chip-Seq_K562_Human1.14823764
91TP53_22573176_ChIP-Seq_HFKS_Human1.11949125
92* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11823325
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11598114
94CBP_20019798_ChIP-Seq_JUKART_Human1.11598114
95RNF2_27304074_Chip-Seq_NSC_Mouse1.11109586
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10603007
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09985132
98* AR_19668381_ChIP-Seq_PC3_Human1.08877239
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07770040
100ELK1_19687146_ChIP-ChIP_HELA_Human1.07343911
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07289184
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07172929
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06847442
104* STAT3_23295773_ChIP-Seq_U87_Human1.06173064
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05896686
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05291032
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02882021
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02083146
109SOX2_16153702_ChIP-ChIP_HESCs_Human1.02082113
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01835981
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01768498
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.01749264
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.01098207
114* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99713337
115TCF4_23295773_ChIP-Seq_U87_Human0.98107890
116* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96743028
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96426237
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96182630
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95692820
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95598529
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94108386
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94002479
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93818457
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93419676
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93250956
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93157038
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92895841
128AR_25329375_ChIP-Seq_VCAP_Human0.92755090
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92570865
130SOX2_21211035_ChIP-Seq_LN229_Gbm0.92501847
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91467374
132XRN2_22483619_ChIP-Seq_HELA_Human0.91190514
133MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90699197
134NANOG_19829295_ChIP-Seq_ESCs_Human0.90568856
135SOX2_19829295_ChIP-Seq_ESCs_Human0.90568856
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.90549137
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90292417
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.89033203
139OCT4_19829295_ChIP-Seq_ESCs_Human0.88611888
140KLF4_19829295_ChIP-Seq_ESCs_Human0.88103894
141P53_22387025_ChIP-Seq_ESCs_Mouse0.87360629
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.87040857
143* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86810387
144ETS1_20019798_ChIP-Seq_JURKAT_Human0.86779207
145TCF4_22108803_ChIP-Seq_LS180_Human0.86180887
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86124410
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.85862914
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.85827930
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84961598
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84711852
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84567629
152RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84286977
153FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84165890
154FOXA1_25329375_ChIP-Seq_VCAP_Human0.84165890
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83913476
156AR_20517297_ChIP-Seq_VCAP_Human0.83761983
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.83349826
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81844603
159P68_20966046_ChIP-Seq_HELA_Human0.81691208
160SMAD4_21799915_ChIP-Seq_A2780_Human0.81364053
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80269984
162SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.80177464
163SOX3_22085726_ChIP-Seq_NPCs_Mouse0.80122354
164MYC_18555785_ChIP-Seq_MESCs_Mouse0.80077083
165FOXP1_21924763_ChIP-Seq_HESCs_Human0.79391887
166SOX9_26525672_Chip-Seq_HEART_Mouse0.79171897
167P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78806073
168CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78487312
169* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78430684
170E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78103310
171NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78094971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.06074519
2MP0004270_analgesia3.25136447
3MP0003635_abnormal_synaptic_transmissio3.06130786
4MP0003880_abnormal_central_pattern2.82096849
5MP0001968_abnormal_touch/_nociception2.79254282
6MP0005423_abnormal_somatic_nervous2.65232213
7MP0003136_yellow_coat_color2.59836196
8MP0002735_abnormal_chemical_nociception2.59436683
9MP0003646_muscle_fatigue2.52696864
10MP0002734_abnormal_mechanical_nocicepti2.46160781
11MP0002063_abnormal_learning/memory/cond2.40552637
12MP0004130_abnormal_muscle_cell2.38631841
13MP0004858_abnormal_nervous_system2.32186627
14MP0009046_muscle_twitch2.26563255
15MP0002064_seizures2.21716782
16MP0000569_abnormal_digit_pigmentation2.19472526
17MP0002822_catalepsy2.18033939
18MP0009745_abnormal_behavioral_response2.15764204
19MP0002733_abnormal_thermal_nociception2.13766629
20MP0006276_abnormal_autonomic_nervous2.12694797
21MP0002736_abnormal_nociception_after2.05774530
22MP0002184_abnormal_innervation2.02115997
23MP0002272_abnormal_nervous_system1.99299879
24MP0002572_abnormal_emotion/affect_behav1.95387368
25MP0001486_abnormal_startle_reflex1.92719419
26MP0000778_abnormal_nervous_system1.91756520
27MP0003122_maternal_imprinting1.90622423
28MP0004811_abnormal_neuron_physiology1.90241742
29MP0002653_abnormal_ependyma_morphology1.79002307
30MP0002638_abnormal_pupillary_reflex1.77113856
31MP0000955_abnormal_spinal_cord1.75613122
32MP0001970_abnormal_pain_threshold1.73947839
33MP0000749_muscle_degeneration1.71681003
34MP0005670_abnormal_white_adipose1.70729129
35MP0002067_abnormal_sensory_capabilities1.70547827
36MP0004233_abnormal_muscle_weight1.69294632
37MP0006292_abnormal_olfactory_placode1.65309403
38MP0006072_abnormal_retinal_apoptosis1.62775225
39MP0002837_dystrophic_cardiac_calcinosis1.60815910
40MP0005551_abnormal_eye_electrophysiolog1.60524778
41MP0005499_abnormal_olfactory_system1.57687959
42MP0005394_taste/olfaction_phenotype1.57687959
43MP0002882_abnormal_neuron_morphology1.56761154
44MP0004215_abnormal_myocardial_fiber1.55476012
45MP0003195_calcinosis1.53536536
46MP0002557_abnormal_social/conspecific_i1.52154323
47MP0005365_abnormal_bile_salt1.52120757
48MP0008569_lethality_at_weaning1.52069997
49MP0002938_white_spotting1.46824612
50MP0002909_abnormal_adrenal_gland1.44626776
51MP0003123_paternal_imprinting1.43826880
52MP0006036_abnormal_mitochondrial_physio1.37764554
53MP0004142_abnormal_muscle_tone1.36622127
54MP0005083_abnormal_biliary_tract1.36199553
55MP0003283_abnormal_digestive_organ1.34184886
56MP0002106_abnormal_muscle_physiology1.33056260
57MP0006035_abnormal_mitochondrial_morpho1.31827828
58MP0005253_abnormal_eye_physiology1.30991663
59MP0002152_abnormal_brain_morphology1.30305752
60MP0002751_abnormal_autonomic_nervous1.28587188
61MP0005085_abnormal_gallbladder_physiolo1.28358231
62MP0004924_abnormal_behavior1.26994945
63MP0005386_behavior/neurological_phenoty1.26994945
64MP0008789_abnormal_olfactory_epithelium1.26024072
65MP0002066_abnormal_motor_capabilities/c1.25192345
66MP0004147_increased_porphyrin_level1.25163763
67MP0000631_abnormal_neuroendocrine_gland1.25078740
68MP0001485_abnormal_pinna_reflex1.23793175
69MP0001529_abnormal_vocalization1.23574484
70MP0001986_abnormal_taste_sensitivity1.22792997
71MP0003567_abnormal_fetal_cardiomyocyte1.20083744
72MP0008875_abnormal_xenobiotic_pharmacok1.18825056
73MP0001984_abnormal_olfaction1.17676552
74MP0001440_abnormal_grooming_behavior1.16883915
75MP0003861_abnormal_nervous_system1.16782693
76MP0000750_abnormal_muscle_regeneration1.16674397
77MP0003787_abnormal_imprinting1.16034868
78MP0005369_muscle_phenotype1.14820428
79MP0003121_genomic_imprinting1.14773137
80MP0002752_abnormal_somatic_nervous1.14300968
81MP0005332_abnormal_amino_acid1.13903002
82MP0004133_heterotaxia1.13318082
83MP0008961_abnormal_basal_metabolism1.12246811
84MP0002229_neurodegeneration1.10935374
85MP0001188_hyperpigmentation1.09943937
86MP0003890_abnormal_embryonic-extraembry1.09740235
87MP0004145_abnormal_muscle_electrophysio1.09518141
88MP0003119_abnormal_digestive_system1.09375266
89MP0005084_abnormal_gallbladder_morpholo1.08666715
90MP0002876_abnormal_thyroid_physiology1.08604073
91MP0004885_abnormal_endolymph1.07196445
92MP0005620_abnormal_muscle_contractility1.06746368
93MP0001293_anophthalmia1.05651803
94MP0003315_abnormal_perineum_morphology1.04790992
95MP0002269_muscular_atrophy1.02140641
96MP0004036_abnormal_muscle_relaxation1.01831869
97MP0005187_abnormal_penis_morphology1.00594190
98MP0001299_abnormal_eye_distance/0.99839599
99MP0002234_abnormal_pharynx_morphology0.99493221
100MP0002102_abnormal_ear_morphology0.99143011
101MP0001502_abnormal_circadian_rhythm0.98918207
102MP0003938_abnormal_ear_development0.98035283
103MP0002971_abnormal_brown_adipose0.97899022
104MP0005174_abnormal_tail_pigmentation0.96785752
105MP0009780_abnormal_chondrocyte_physiolo0.95285553
106MP0010329_abnormal_lipoprotein_level0.93306216
107MP0003942_abnormal_urinary_system0.92498771
108MP0001501_abnormal_sleep_pattern0.91248282
109MP0000747_muscle_weakness0.90729707
110MP0004085_abnormal_heartbeat0.90662198
111MP0005645_abnormal_hypothalamus_physiol0.87592737
112MP0004087_abnormal_muscle_fiber0.87390556
113MP0003011_delayed_dark_adaptation0.86721867
114MP0000537_abnormal_urethra_morphology0.85871584
115MP0000534_abnormal_ureter_morphology0.85581443
116MP0003879_abnormal_hair_cell0.84695090
117MP0005646_abnormal_pituitary_gland0.84403228
118MP0001764_abnormal_homeostasis0.83545642
119MP0002069_abnormal_eating/drinking_beha0.83520580
120MP0005409_darkened_coat_color0.82963296
121MP0005171_absent_coat_pigmentation0.82228759
122MP0001905_abnormal_dopamine_level0.81259368
123MP0000678_abnormal_parathyroid_gland0.80878781
124MP0005448_abnormal_energy_balance0.80773283
125MP0000026_abnormal_inner_ear0.78663793
126MP0008877_abnormal_DNA_methylation0.78136138
127MP0003329_amyloid_beta_deposits0.76977307
128MP0000751_myopathy0.75828325
129MP0003137_abnormal_impulse_conducting0.75037878
130MP0002081_perinatal_lethality0.72949043
131MP0010030_abnormal_orbit_morphology0.71827315
132MP0004043_abnormal_pH_regulation0.71510690
133MP0001963_abnormal_hearing_physiology0.70715505
134MP0010769_abnormal_survival0.69760459
135MP0010386_abnormal_urinary_bladder0.68128930
136MP0002160_abnormal_reproductive_system0.67983841
137MP0003634_abnormal_glial_cell0.67981009
138MP0009672_abnormal_birth_weight0.67815078
139MP0010768_mortality/aging0.67323513

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.95328556
2Focal motor seizures (HP:0011153)3.83017716
3Visual hallucinations (HP:0002367)3.75178068
4Nemaline bodies (HP:0003798)3.63374200
5Muscle fiber inclusion bodies (HP:0100299)3.57565299
6Exercise-induced muscle cramps (HP:0003710)3.42487233
7Pheochromocytoma (HP:0002666)3.42370768
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.35954602
9Ankle clonus (HP:0011448)3.26064179
10Focal seizures (HP:0007359)3.25497723
11Abnormality of the lower motor neuron (HP:0002366)3.19404662
12Insomnia (HP:0100785)3.14714752
13Progressive cerebellar ataxia (HP:0002073)3.13233416
14Renal duplication (HP:0000075)3.10149096
15Rimmed vacuoles (HP:0003805)3.06762995
16Hyperacusis (HP:0010780)3.04258380
17Neuroendocrine neoplasm (HP:0100634)2.91112081
18Muscle hypertrophy of the lower extremities (HP:0008968)2.88262843
19Elfin facies (HP:0004428)2.86144957
20Calf muscle hypertrophy (HP:0008981)2.84433672
21Action tremor (HP:0002345)2.84371948
22Epileptic encephalopathy (HP:0200134)2.76193837
23Overriding aorta (HP:0002623)2.75649849
24Urinary urgency (HP:0000012)2.74250616
25Medial flaring of the eyebrow (HP:0010747)2.72882647
26Febrile seizures (HP:0002373)2.67189144
27Gait imbalance (HP:0002141)2.64271355
28Lipid accumulation in hepatocytes (HP:0006561)2.62988225
29Urinary bladder sphincter dysfunction (HP:0002839)2.62481323
30Pointed chin (HP:0000307)2.61907007
31Pancreatic cysts (HP:0001737)2.59428701
32Increased hepatocellular lipid droplets (HP:0006565)2.57945834
33Exercise-induced myalgia (HP:0003738)2.57398722
34Hyperglycinemia (HP:0002154)2.52451714
35Termporal pattern (HP:0011008)2.52365436
36Insidious onset (HP:0003587)2.52365436
37Poor eye contact (HP:0000817)2.50971731
38Large for gestational age (HP:0001520)2.49456621
39Megalencephaly (HP:0001355)2.48429758
40Acute necrotizing encephalopathy (HP:0006965)2.47150784
41Hyperglycinuria (HP:0003108)2.42129527
42Limb dystonia (HP:0002451)2.41569374
43True hermaphroditism (HP:0010459)2.40924878
44Congenital stationary night blindness (HP:0007642)2.40684842
45Truncal ataxia (HP:0002078)2.40550987
46Congenital primary aphakia (HP:0007707)2.40303388
47Pancreatic fibrosis (HP:0100732)2.39954476
48Supranuclear gaze palsy (HP:0000605)2.38869090
49Absence seizures (HP:0002121)2.37845752
50Mitochondrial inheritance (HP:0001427)2.36507828
51Abnormality of serine family amino acid metabolism (HP:0010894)2.35548254
52Abnormality of glycine metabolism (HP:0010895)2.35548254
53Severe visual impairment (HP:0001141)2.34872831
54Generalized tonic-clonic seizures (HP:0002069)2.34755680
55Impaired vibration sensation in the lower limbs (HP:0002166)2.34188933
56Hyperinsulinemic hypoglycemia (HP:0000825)2.33550193
57Renovascular hypertension (HP:0100817)2.32080513
58Neoplasm of the peripheral nervous system (HP:0100007)2.31686456
59Atonic seizures (HP:0010819)2.31558244
60Genetic anticipation (HP:0003743)2.31555964
61Nephrogenic diabetes insipidus (HP:0009806)2.31419049
62Spastic gait (HP:0002064)2.29826456
63Abnormal mitochondria in muscle tissue (HP:0008316)2.29494121
64Nephronophthisis (HP:0000090)2.28908412
65Molar tooth sign on MRI (HP:0002419)2.28180922
66Abnormality of midbrain morphology (HP:0002418)2.28180922
67Flat cornea (HP:0007720)2.26699649
68Agitation (HP:0000713)2.26170895
69Increased intramyocellular lipid droplets (HP:0012240)2.25775719
70Acute encephalopathy (HP:0006846)2.24795528
71Cerebral hypomyelination (HP:0006808)2.24715819
72Increased nuchal translucency (HP:0010880)2.24338126
73Abnormality of the diencephalon (HP:0010662)2.21590856
74Depression (HP:0000716)2.21226788
75Impaired social interactions (HP:0000735)2.19938972
76Abnormal social behavior (HP:0012433)2.19938972
77Failure to thrive in infancy (HP:0001531)2.17722989
78Polyphagia (HP:0002591)2.17425682
79EEG with generalized epileptiform discharges (HP:0011198)2.17330696
80Renal Fanconi syndrome (HP:0001994)2.16154513
81Posterior subcapsular cataract (HP:0007787)2.14235378
82Central scotoma (HP:0000603)2.12786787
83Hypsarrhythmia (HP:0002521)2.12578521
84Increased muscle lipid content (HP:0009058)2.12214160
85Myoglobinuria (HP:0002913)2.12067946
86Methylmalonic acidemia (HP:0002912)2.11774632
87Specific learning disability (HP:0001328)2.10764436
88Abnormality of the corticospinal tract (HP:0002492)2.09685869
89Shoulder girdle muscle weakness (HP:0003547)2.09674430
90Epileptiform EEG discharges (HP:0011182)2.09564147
91Increased CSF lactate (HP:0002490)2.09182762
92Concave nail (HP:0001598)2.08422767
93Amyotrophic lateral sclerosis (HP:0007354)2.07768419
94Dialeptic seizures (HP:0011146)2.05871259
95Progressive macrocephaly (HP:0004481)2.04170328
96Abnormality of serum amino acid levels (HP:0003112)2.02788208
97Broad-based gait (HP:0002136)2.02325331
98Cerebral edema (HP:0002181)2.00937919
99Hepatic necrosis (HP:0002605)1.99382125
100Inability to walk (HP:0002540)1.99252821
101EMG: myopathic abnormalities (HP:0003458)1.98986512
102Poor coordination (HP:0002370)1.97872852
103Amblyopia (HP:0000646)1.97508130
104Abnormality of the aortic arch (HP:0012303)1.96639155
105Vaginal atresia (HP:0000148)1.96587644
106Abnormality of the calf musculature (HP:0001430)1.96461406
107Abnormality of the labia minora (HP:0012880)1.95674047
108Hypoplasia of the brainstem (HP:0002365)1.94831603
109Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94831603
110Genital tract atresia (HP:0001827)1.94433527
111Papilledema (HP:0001085)1.94008238
112Methylmalonic aciduria (HP:0012120)1.93463076
113Myotonia (HP:0002486)1.93253588
114Sacral dimple (HP:0000960)1.92883982
115Sclerocornea (HP:0000647)1.92229654
116Hepatocellular necrosis (HP:0001404)1.91854221
117Type 1 muscle fiber predominance (HP:0003803)1.91835242
118Myopathic facies (HP:0002058)1.90857429
119Ventricular fibrillation (HP:0001663)1.89394551
120Hyperventilation (HP:0002883)1.88658102
121Anxiety (HP:0000739)1.87066511
122Spastic paraplegia (HP:0001258)1.86475053
123Morphological abnormality of the pyramidal tract (HP:0002062)1.85641948
124Colon cancer (HP:0003003)1.85366756
125Abnormality of the renal medulla (HP:0100957)1.85284144
126Clonus (HP:0002169)1.83946200
127Paraplegia (HP:0010550)1.82685337
128Anencephaly (HP:0002323)1.81470381
129Bundle branch block (HP:0011710)1.81025661
130Lissencephaly (HP:0001339)1.81023784
131Hemiparesis (HP:0001269)1.80382798
132Left ventricular hypertrophy (HP:0001712)1.80007135
133Ketosis (HP:0001946)1.79783630
134Abnormality of macular pigmentation (HP:0008002)1.79365167
135Ketoacidosis (HP:0001993)1.78759600
136Progressive inability to walk (HP:0002505)1.78739451
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77559227
138Abnormality of alanine metabolism (HP:0010916)1.77559227
139Hyperalaninemia (HP:0003348)1.77559227
140Obsessive-compulsive behavior (HP:0000722)1.77495699
141Poor suck (HP:0002033)1.76639591
142Exercise intolerance (HP:0003546)1.76605314
143Homocystinuria (HP:0002156)1.76544787
144Abnormality of homocysteine metabolism (HP:0010919)1.76544787
145Neoplasm of the heart (HP:0100544)1.75736255
146Bile duct proliferation (HP:0001408)1.75075289
147Abnormal biliary tract physiology (HP:0012439)1.75075289
148Septo-optic dysplasia (HP:0100842)1.74884488
149Impaired smooth pursuit (HP:0007772)1.74778364
150Bony spicule pigmentary retinopathy (HP:0007737)1.74371608
151Truncus arteriosus (HP:0001660)1.74369519
152Excessive salivation (HP:0003781)1.74217424
153Drooling (HP:0002307)1.74217424
154Annular pancreas (HP:0001734)1.74016054
155Syncope (HP:0001279)1.73490578
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72864762
157Abnormal rod and cone electroretinograms (HP:0008323)1.72541217
158Postural tremor (HP:0002174)1.72031489
159Atrophy/Degeneration involving motor neurons (HP:0007373)1.71819129
160Autism (HP:0000717)1.71809094
161Adducted thumb (HP:0001181)1.71803779
162Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71154066
163Megalocornea (HP:0000485)1.70308546
164Facial diplegia (HP:0001349)1.69832199
165Generalized hypotonia (HP:0001290)1.69653246
166Lactic acidosis (HP:0003128)1.68785767
167Frequent falls (HP:0002359)1.68583412
168Ulnar claw (HP:0001178)1.68424035
169Abnormal eating behavior (HP:0100738)1.68069120
170Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67977985
171Spastic tetraparesis (HP:0001285)1.67835902
172Akinesia (HP:0002304)1.67316713
173Scotoma (HP:0000575)1.66529197
174Bowel diverticulosis (HP:0005222)1.66323307
175Abnormality of methionine metabolism (HP:0010901)1.66026976
176Lower limb muscle weakness (HP:0007340)1.65859245
177Decreased circulating renin level (HP:0003351)1.65793708
178Fetal akinesia sequence (HP:0001989)1.65392394
179Prolonged QT interval (HP:0001657)1.64656546
180Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63921901
181Intellectual disability, profound (HP:0002187)1.63722409
182Dysdiadochokinesis (HP:0002075)1.63650219
183Muscular hypotonia of the trunk (HP:0008936)1.63330905
184Abnormality of pain sensation (HP:0010832)1.63269542
185Impaired pain sensation (HP:0007328)1.63269542
186Ankyloglossia (HP:0010296)1.61259637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.32230828
2MARK13.88533485
3OBSCN3.87650298
4NTRK33.84821341
5MINK12.93600433
6MAP3K42.55717108
7FRK2.32468387
8NEK12.31972244
9ZAK2.14922278
10STK162.14410431
11TNIK2.13883365
12PRKD32.13773162
13PAK62.11047337
14MAP2K72.09851315
15LATS22.02768323
16TRIM281.99278097
17LIMK11.95997733
18KSR21.92042009
19UHMK11.74481938
20NTRK11.72014924
21BMPR1B1.71598294
22NTRK21.68072439
23STK38L1.68024729
24PHKG11.61386462
25PHKG21.61386462
26KSR11.59590350
27BCR1.59434804
28ACVR1B1.57293949
29MAP2K41.54397692
30ADRBK21.52907573
31DAPK21.49493292
32MAPK131.47357927
33MUSK1.46843644
34MAP4K21.42466945
35PNCK1.30798841
36OXSR11.29503491
37VRK11.28363582
38MAP3K121.27686793
39TAF11.27661410
40BRSK11.27031750
41CDK51.24581617
42LMTK21.23938357
43CAMKK11.21548344
44GRK51.18406901
45BRAF1.18018900
46ALK1.16583376
47CDK141.14678568
48DYRK21.14474566
49CDK181.10532818
50CDK151.06438449
51GRK11.05070661
52SIK21.04959682
53CAMK1D1.04642353
54SIK31.04395157
55PRKCG1.03504184
56BCKDK1.02699852
57CDC42BPA1.01370598
58CDK11A1.00791463
59NME11.00769836
60SGK4941.00670723
61SGK2231.00670723
62DYRK31.00103067
63DAPK10.99250719
64TAOK10.98646801
65PRKAA10.96832839
66PIK3CA0.96618030
67CDK190.95851523
68MAP3K20.95089243
69CCNB10.94622347
70TYRO30.94061694
71CSNK1G20.92484718
72DYRK1B0.91579514
73PRKAA20.90928028
74STK380.90154624
75PAK30.88943263
76BUB10.87565295
77CSNK1G10.86955322
78RIPK10.86844018
79TSSK60.84157918
80ERBB30.83317540
81MAP3K70.83012848
82NLK0.81423014
83RET0.81419410
84SCYL20.80733677
85WNK10.80014433
86PRPF4B0.79054332
87TLK10.77219163
88CAMK1G0.75835517
89EPHA40.74806496
90CSNK1G30.74322770
91PLK20.73631190
92MARK20.72901984
93PINK10.69597706
94NUAK10.68983317
95WNK30.67850354
96PDK20.67118637
97CSNK1E0.66978018
98PRKCE0.66439530
99BRSK20.66075308
100CAMK2D0.65570903
101AURKA0.64167684
102PLK30.64041571
103ARAF0.63992670
104CAMK2B0.63139281
105CDC70.62547200
106DYRK1A0.62284708
107CAMKK20.62081131
108SGK20.61718884
109ICK0.59806554
110TESK10.56877631
111FGFR10.56499076
112BRD40.55594094
113AKT30.54439776
114MAPK100.54205696
115CAMK10.53627611
116PKN10.52700816
117PASK0.52158613
118STK110.51822766
119RPS6KA20.51636062
120FGFR20.49795112
121CLK10.48811174
122PLK10.48402903
123STK240.47699230
124CDK30.46791338
125PRKACA0.46550129
126CAMK2G0.46083332
127ADRBK10.45653962
128PDGFRA0.44980208
129CSNK1A1L0.44266755
130EPHB20.43756298
131MAPK90.43655301
132VRK20.43473270
133SGK30.42372117
134CASK0.42276279
135SGK10.42135436
136EPHA30.42068951
137PRKCZ0.40879477
138CAMK2A0.40154578
139PRKG10.39791021
140MAP3K100.39719528
141MAP2K60.39612297
142CSNK1A10.39609740
143PRKACB0.39473918
144MAP2K10.39230027
145SRPK10.39133695
146CDK20.39118802
147GSK3B0.38644890
148EIF2AK10.38327814
149RPS6KA30.37372056
150CDK10.37202961
151PRKCB0.37102254
152CAMK40.37016129

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.68570629
2Nicotine addiction_Homo sapiens_hsa050332.74890580
3Phototransduction_Homo sapiens_hsa047442.61447697
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.61323965
5Oxidative phosphorylation_Homo sapiens_hsa001902.51497694
6GABAergic synapse_Homo sapiens_hsa047272.37953579
7Propanoate metabolism_Homo sapiens_hsa006402.27404652
8Circadian entrainment_Homo sapiens_hsa047132.23930972
9Long-term potentiation_Homo sapiens_hsa047202.13548452
10Dopaminergic synapse_Homo sapiens_hsa047282.13128562
11Parkinsons disease_Homo sapiens_hsa050122.12558899
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11698951
13Insulin secretion_Homo sapiens_hsa049112.10677052
14Olfactory transduction_Homo sapiens_hsa047402.10184782
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01905334
16Morphine addiction_Homo sapiens_hsa050321.92216774
17Glutamatergic synapse_Homo sapiens_hsa047241.91377427
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89042615
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86263054
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84268891
21Oocyte meiosis_Homo sapiens_hsa041141.77009888
22Amphetamine addiction_Homo sapiens_hsa050311.75258787
23Cholinergic synapse_Homo sapiens_hsa047251.74961018
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67257562
25Pyruvate metabolism_Homo sapiens_hsa006201.63072235
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58101461
27Caffeine metabolism_Homo sapiens_hsa002321.56141782
28Selenocompound metabolism_Homo sapiens_hsa004501.55816690
29Alzheimers disease_Homo sapiens_hsa050101.55204586
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54659110
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54406677
32Fatty acid degradation_Homo sapiens_hsa000711.48504510
33Taste transduction_Homo sapiens_hsa047421.47618251
34Serotonergic synapse_Homo sapiens_hsa047261.39077558
35Gap junction_Homo sapiens_hsa045401.38065288
36Oxytocin signaling pathway_Homo sapiens_hsa049211.37350760
37Huntingtons disease_Homo sapiens_hsa050161.37223832
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36822286
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33649029
40Type II diabetes mellitus_Homo sapiens_hsa049301.32063663
41Long-term depression_Homo sapiens_hsa047301.31551592
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31179615
43Vitamin B6 metabolism_Homo sapiens_hsa007501.30398656
44Peroxisome_Homo sapiens_hsa041461.29944022
45beta-Alanine metabolism_Homo sapiens_hsa004101.29362420
46Cocaine addiction_Homo sapiens_hsa050301.29258599
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.28287875
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28168274
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26690644
50Arginine and proline metabolism_Homo sapiens_hsa003301.26620066
51Tryptophan metabolism_Homo sapiens_hsa003801.25729839
52Regulation of autophagy_Homo sapiens_hsa041401.25498718
53Axon guidance_Homo sapiens_hsa043601.22106769
54GnRH signaling pathway_Homo sapiens_hsa049121.19186177
55Nitrogen metabolism_Homo sapiens_hsa009101.19090973
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18274332
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17828803
58ErbB signaling pathway_Homo sapiens_hsa040121.17009243
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16257471
60Fatty acid metabolism_Homo sapiens_hsa012121.16123943
61Gastric acid secretion_Homo sapiens_hsa049711.14498173
62Glioma_Homo sapiens_hsa052141.13386192
63Salivary secretion_Homo sapiens_hsa049701.11310458
64mTOR signaling pathway_Homo sapiens_hsa041501.09057988
65Histidine metabolism_Homo sapiens_hsa003401.05661549
66Linoleic acid metabolism_Homo sapiens_hsa005911.04159966
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04091439
68Melanogenesis_Homo sapiens_hsa049161.03516519
69Steroid biosynthesis_Homo sapiens_hsa001001.03293382
70Endometrial cancer_Homo sapiens_hsa052131.02662730
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02103752
72Arginine biosynthesis_Homo sapiens_hsa002201.01803873
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01604434
74Cardiac muscle contraction_Homo sapiens_hsa042601.01410620
75Estrogen signaling pathway_Homo sapiens_hsa049150.98427890
76Carbon metabolism_Homo sapiens_hsa012000.97378318
77Protein export_Homo sapiens_hsa030600.97221231
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96263378
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94821994
80Calcium signaling pathway_Homo sapiens_hsa040200.93781671
81Insulin signaling pathway_Homo sapiens_hsa049100.92760820
82Renin secretion_Homo sapiens_hsa049240.91656239
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.91441729
84mRNA surveillance pathway_Homo sapiens_hsa030150.90907584
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88945277
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88913148
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.88264628
88Alcoholism_Homo sapiens_hsa050340.87400585
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.87396760
90Vibrio cholerae infection_Homo sapiens_hsa051100.86898887
91Chemical carcinogenesis_Homo sapiens_hsa052040.86041543
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84923928
93Hedgehog signaling pathway_Homo sapiens_hsa043400.83337664
94Retinol metabolism_Homo sapiens_hsa008300.82991250
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79703799
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79117808
97Sulfur metabolism_Homo sapiens_hsa009200.77992984
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.77387842
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77281130
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76548265
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76291061
102Wnt signaling pathway_Homo sapiens_hsa043100.75845655
103PPAR signaling pathway_Homo sapiens_hsa033200.75801534
104Collecting duct acid secretion_Homo sapiens_hsa049660.75189452
105Basal transcription factors_Homo sapiens_hsa030220.74637288
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73205071
107Non-small cell lung cancer_Homo sapiens_hsa052230.71583471
108Colorectal cancer_Homo sapiens_hsa052100.70800189
109Metabolic pathways_Homo sapiens_hsa011000.70604449
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70583801
111cAMP signaling pathway_Homo sapiens_hsa040240.70341890
112Circadian rhythm_Homo sapiens_hsa047100.70021921
113Glucagon signaling pathway_Homo sapiens_hsa049220.69618248
114Fat digestion and absorption_Homo sapiens_hsa049750.68862151
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68510882
116Glycerolipid metabolism_Homo sapiens_hsa005610.68315713
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68129271
118Starch and sucrose metabolism_Homo sapiens_hsa005000.68018009
119RNA polymerase_Homo sapiens_hsa030200.67793213
120Bile secretion_Homo sapiens_hsa049760.67665677
121VEGF signaling pathway_Homo sapiens_hsa043700.66998427
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66966305
123Hippo signaling pathway_Homo sapiens_hsa043900.66660289
124RNA transport_Homo sapiens_hsa030130.66154226
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65847382
126Mismatch repair_Homo sapiens_hsa034300.65596997
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65352314
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.64197939
129Fructose and mannose metabolism_Homo sapiens_hsa000510.64060690
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63233360
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.61551398
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61262133
133Renal cell carcinoma_Homo sapiens_hsa052110.58816669
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57643833
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57213551
136Type I diabetes mellitus_Homo sapiens_hsa049400.57208841
137Ether lipid metabolism_Homo sapiens_hsa005650.55816540
138Phenylalanine metabolism_Homo sapiens_hsa003600.55620044
139Choline metabolism in cancer_Homo sapiens_hsa052310.54837534
140Endocytosis_Homo sapiens_hsa041440.54269823
141Vitamin digestion and absorption_Homo sapiens_hsa049770.53550077
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52639532
143Biosynthesis of amino acids_Homo sapiens_hsa012300.52509327
144Spliceosome_Homo sapiens_hsa030400.52380181
145MAPK signaling pathway_Homo sapiens_hsa040100.52336216
146Nucleotide excision repair_Homo sapiens_hsa034200.51444738
147AMPK signaling pathway_Homo sapiens_hsa041520.51429710
148Cell cycle_Homo sapiens_hsa041100.50847259
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49891006
150Ovarian steroidogenesis_Homo sapiens_hsa049130.49071613
151Basal cell carcinoma_Homo sapiens_hsa052170.49055895
152Tyrosine metabolism_Homo sapiens_hsa003500.48735914
153Sulfur relay system_Homo sapiens_hsa041220.48662009
154Thyroid cancer_Homo sapiens_hsa052160.48386269
155Melanoma_Homo sapiens_hsa052180.48242030
156RNA degradation_Homo sapiens_hsa030180.47690231
157Prion diseases_Homo sapiens_hsa050200.47469207
158Dorso-ventral axis formation_Homo sapiens_hsa043200.47300950
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46723131
160Prolactin signaling pathway_Homo sapiens_hsa049170.46402389
161Dilated cardiomyopathy_Homo sapiens_hsa054140.45587248
162Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44393167
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.43120081
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41586298
165Butanoate metabolism_Homo sapiens_hsa006500.40718103

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