AP5B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.79834507
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.79834507
3positive regulation of gamma-delta T cell activation (GO:0046645)5.31090662
4antigen processing and presentation of endogenous antigen (GO:0019883)5.23804944
5detection of other organism (GO:0098543)4.83372578
6leukocyte aggregation (GO:0070486)4.57943871
7detection of bacterium (GO:0016045)4.56128934
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55444301
9regulation of B cell receptor signaling pathway (GO:0050855)4.51606623
10detection of molecule of bacterial origin (GO:0032490)4.27801185
11detection of external biotic stimulus (GO:0098581)4.18268534
12regulation of gamma-delta T cell differentiation (GO:0045586)4.09269416
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.06131254
14modulation by symbiont of host immune response (GO:0052553)4.06131254
15positive regulation by symbiont of host defense response (GO:0052509)4.06131254
16modulation by symbiont of host defense response (GO:0052031)4.06131254
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06131254
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06131254
19negative regulation of phagocytosis (GO:0050765)4.05990182
20respiratory burst (GO:0045730)4.03001422
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.98350666
22regulation of gamma-delta T cell activation (GO:0046643)3.96348594
23negative regulation of erythrocyte differentiation (GO:0045647)3.95486594
24positive regulation of B cell differentiation (GO:0045579)3.93517677
25response to peptidoglycan (GO:0032494)3.93332544
26neutrophil activation involved in immune response (GO:0002283)3.91853023
27regulation of interferon-beta biosynthetic process (GO:0045357)3.84988833
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79524032
29immunoglobulin mediated immune response (GO:0016064)3.77945846
30detection of biotic stimulus (GO:0009595)3.72808498
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.71361163
32regulation of mast cell degranulation (GO:0043304)3.64721152
33regulation of B cell differentiation (GO:0045577)3.62692315
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.58815598
35negative regulation of cell killing (GO:0031342)3.58815598
36macrophage activation (GO:0042116)3.55058233
37lipopolysaccharide-mediated signaling pathway (GO:0031663)3.54750722
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.48983189
39regulation of leukocyte degranulation (GO:0043300)3.44765937
40antigen processing and presentation via MHC class Ib (GO:0002475)3.43542418
41regulation of myeloid leukocyte mediated immunity (GO:0002886)3.42019169
42germinal center formation (GO:0002467)3.40147105
43response to fungus (GO:0009620)3.39345804
44neutrophil mediated immunity (GO:0002446)3.38009104
45B cell receptor signaling pathway (GO:0050853)3.36522422
46microglial cell activation (GO:0001774)3.35435110
47leukocyte migration involved in inflammatory response (GO:0002523)3.34739826
48cellular extravasation (GO:0045123)3.34348590
49positive regulation of antigen processing and presentation (GO:0002579)3.33408383
50regulation of mast cell activation involved in immune response (GO:0033006)3.32063880
51NIK/NF-kappaB signaling (GO:0038061)3.31742028
52neutrophil activation (GO:0042119)3.31175065
53macrophage activation involved in immune response (GO:0002281)3.30081018
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.28788777
55negative regulation of T cell mediated immunity (GO:0002710)3.28000922
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27439533
57regulation of T-helper 2 cell differentiation (GO:0045628)3.25165392
58response to muramyl dipeptide (GO:0032495)3.23819236
59negative regulation of leukocyte mediated immunity (GO:0002704)3.23200719
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22766454
61positive regulation of interferon-alpha production (GO:0032727)3.21861994
62leukocyte cell-cell adhesion (GO:0007159)3.17213340
63granulocyte activation (GO:0036230)3.14898865
64positive thymic T cell selection (GO:0045059)3.14865161
65defense response to fungus (GO:0050832)3.14733779
66JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.12193806
67positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10852310
68regulation of interferon-alpha production (GO:0032647)3.08071364
69positive regulation of mast cell activation (GO:0033005)3.07000019
70T cell migration (GO:0072678)3.02494853
71negative regulation of cytokine production involved in immune response (GO:0002719)3.02406958
72regulation of interleukin-12 biosynthetic process (GO:0045075)3.00848014
73negative regulation of interleukin-6 production (GO:0032715)3.00201683
74regulation of type I interferon-mediated signaling pathway (GO:0060338)2.99139163
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98720864
76response to type I interferon (GO:0034340)2.98561357
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96025178
78myeloid cell activation involved in immune response (GO:0002275)2.95660017
79positive regulation of cellular amide metabolic process (GO:0034250)2.95501377
80type I interferon signaling pathway (GO:0060337)2.95168792
81cellular response to type I interferon (GO:0071357)2.95168792
82B cell mediated immunity (GO:0019724)2.95110901
83defense response to protozoan (GO:0042832)2.91186508
84myeloid dendritic cell activation (GO:0001773)2.90802777
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90084569
86response to host immune response (GO:0052572)2.90084569
87regulation of regulated secretory pathway (GO:1903305)2.89846359
88T-helper 1 type immune response (GO:0042088)2.87790690
89leukocyte degranulation (GO:0043299)2.86888491
90response to protozoan (GO:0001562)2.86684055
91negative regulation of interleukin-12 production (GO:0032695)2.85425647
92actin nucleation (GO:0045010)2.83301527
93leukocyte mediated cytotoxicity (GO:0001909)2.82360223
94regulation of antigen processing and presentation (GO:0002577)2.81942476
95interferon-gamma-mediated signaling pathway (GO:0060333)2.81565550
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80365912
97negative regulation of innate immune response (GO:0045824)2.80169387
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.78367499
99response to host (GO:0075136)2.78367499
100response to host defenses (GO:0052200)2.78367499
101pentose-phosphate shunt (GO:0006098)2.77977932
102myeloid dendritic cell differentiation (GO:0043011)2.77957156
103positive regulation of mast cell activation involved in immune response (GO:0033008)2.77646677
104positive regulation of mast cell degranulation (GO:0043306)2.77646677
105negative thymic T cell selection (GO:0045060)2.77584512
106regulation of T cell tolerance induction (GO:0002664)2.77519985
107natural killer cell mediated immunity (GO:0002228)2.77223893
108natural killer cell mediated cytotoxicity (GO:0042267)2.77223893
109mannose metabolic process (GO:0006013)2.76337496
110regulation of tolerance induction (GO:0002643)2.76089856
111negative regulation of type 2 immune response (GO:0002829)2.76002008
112negative regulation of toll-like receptor signaling pathway (GO:0034122)2.75723804
113negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.75606023
114positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73991990
115neutrophil chemotaxis (GO:0030593)2.73177615
116pinocytosis (GO:0006907)2.70376625
117negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70265391
118positive regulation of type 2 immune response (GO:0002830)2.69451275
119hepatocyte apoptotic process (GO:0097284)2.68843400
120regulation of response to interferon-gamma (GO:0060330)2.68617505
121negative T cell selection (GO:0043383)2.66095654
122tolerance induction (GO:0002507)2.65829554
123positive regulation of toll-like receptor signaling pathway (GO:0034123)2.65778788
124neutrophil migration (GO:1990266)2.65633671
125regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.61990785
126mast cell activation (GO:0045576)2.61088074
127cellular response to zinc ion (GO:0071294)2.60570273
128response to interleukin-15 (GO:0070672)2.58510419
129barbed-end actin filament capping (GO:0051016)2.57600307
130regulation of T cell receptor signaling pathway (GO:0050856)2.56811822
131myeloid leukocyte mediated immunity (GO:0002444)2.55380580
132interferon-gamma production (GO:0032609)2.53936756
133regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52782493
134production of molecular mediator involved in inflammatory response (GO:0002532)2.52778638
135regulation of interleukin-8 biosynthetic process (GO:0045414)2.51637007
136thymic T cell selection (GO:0045061)2.51340740
137killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.51291570
138disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.51291570
139negative regulation of granulocyte differentiation (GO:0030853)2.50014271
140dendritic cell differentiation (GO:0097028)2.49302618
141myeloid leukocyte activation (GO:0002274)2.47140355
142regulation of mast cell activation (GO:0033003)2.46242414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.13338661
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.92546491
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.29847897
4E2F7_22180533_ChIP-Seq_HELA_Human3.23007314
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03577535
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.01004097
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.98262938
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96569203
9VDR_21846776_ChIP-Seq_THP-1_Human2.84714468
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.82206974
11MYC_22102868_ChIP-Seq_BL_Human2.78885727
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76731841
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74787949
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73409570
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.69783447
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65033610
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47806971
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42883757
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.41241771
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.39956097
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34890099
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30641763
23SCL_19346495_ChIP-Seq_HPC-7_Human2.28426081
24SPI1_23547873_ChIP-Seq_NB4_Human2.24474445
25MAF_26560356_Chip-Seq_TH1_Human2.21745591
26VDR_24763502_ChIP-Seq_THP-1_Human2.21416348
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19234257
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.17594962
29MYB_26560356_Chip-Seq_TH2_Human2.17169689
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12109522
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02781833
32UTX_26944678_Chip-Seq_JUKART_Human2.01049528
33MYB_26560356_Chip-Seq_TH1_Human1.98361064
34TCF7_22412390_ChIP-Seq_EML_Mouse1.93431466
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86747456
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86424243
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81633799
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.79489164
39RUNX_20019798_ChIP-Seq_JUKART_Human1.73869338
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71133810
41SPI1_23127762_ChIP-Seq_K562_Human1.68095788
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64248840
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61363955
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55697133
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55568859
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51123453
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48646885
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47837785
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47783988
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46192863
51MAF_26560356_Chip-Seq_TH2_Human1.45430360
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44702062
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42656958
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.40223625
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39117902
56PU_27001747_Chip-Seq_BMDM_Mouse1.37713841
57RACK7_27058665_Chip-Seq_MCF-7_Human1.37279660
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36172875
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35547352
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34995872
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.34432084
62KDM2B_26808549_Chip-Seq_DND41_Human1.33209113
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32973492
64GATA3_27048872_Chip-Seq_THYMUS_Human1.30954842
65GATA1_22025678_ChIP-Seq_K562_Human1.29932526
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24495139
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23923035
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23634633
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21243109
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19700963
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18377171
72KDM2B_26808549_Chip-Seq_K562_Human1.17304711
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15640337
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15045818
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14910867
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14174861
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13305270
78LXR_22292898_ChIP-Seq_THP-1_Human1.11736625
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11560513
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.11480301
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10239193
82TFEB_21752829_ChIP-Seq_HELA_Human1.08139615
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06564389
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06292051
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.06012714
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05034774
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03604196
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03075581
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.00538175
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.00490259
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99500428
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99185145
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98881396
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.97348875
95GATA3_26560356_Chip-Seq_TH2_Human0.97240917
96BCL6_27268052_Chip-Seq_Bcells_Human0.97130897
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95947432
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95568371
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94838915
100E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94601029
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.94151728
102P68_20966046_ChIP-Seq_HELA_Human0.93709891
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.92010236
104CIITA_25753668_ChIP-Seq_RAJI_Human0.91288169
105SPI1_20517297_ChIP-Seq_HL60_Human0.90642133
106NCOR1_26117541_ChIP-Seq_K562_Human0.90242859
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89002453
108PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88760296
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88360669
110VDR_24787735_ChIP-Seq_THP-1_Human0.87729157
111BCOR_27268052_Chip-Seq_Bcells_Human0.87445824
112GATA1_19941826_ChIP-Seq_K562_Human0.85386393
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83352326
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81343930
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.80875605
116ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78982753
117P300_27268052_Chip-Seq_Bcells_Human0.78606239
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.77980337
119GATA2_19941826_ChIP-Seq_K562_Human0.77754817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.63465673
2MP0003303_peritoneal_inflammation3.22640722
3MP0003436_decreased_susceptibility_to3.09978268
4MP0000685_abnormal_immune_system2.95795846
5MP0009785_altered_susceptibility_to2.81293747
6MP0005058_abnormal_lysosome_morphology2.72882890
7MP0001800_abnormal_humoral_immune2.62936779
8MP0005387_immune_system_phenotype2.61846253
9MP0001790_abnormal_immune_system2.61846253
10MP0002419_abnormal_innate_immunity2.60487290
11MP0005000_abnormal_immune_tolerance2.57417842
12MP0005671_abnormal_response_to2.56168740
13MP0005025_abnormal_response_to2.50645001
14MP0002452_abnormal_antigen_presenting2.47555434
15MP0003300_gastrointestinal_ulcer2.40157703
16MP0005464_abnormal_platelet_physiology2.39929624
17MP0002166_altered_tumor_susceptibility2.38313285
18MP0003172_abnormal_lysosome_physiology2.37163583
19MP0002723_abnormal_immune_serum2.35157267
20MP0005451_abnormal_body_composition2.34180058
21MP0002420_abnormal_adaptive_immunity2.31722296
22MP0001819_abnormal_immune_cell2.30608243
23MP0008260_abnormal_autophagy2.23337692
24MP0002148_abnormal_hypersensitivity_rea2.15160062
25MP0006082_CNS_inflammation2.11928789
26MP0002396_abnormal_hematopoietic_system2.10617638
27MP0002405_respiratory_system_inflammati2.10002432
28MP0002398_abnormal_bone_marrow2.05319893
29MP0003763_abnormal_thymus_physiology2.04537275
30MP0009278_abnormal_bone_marrow1.96634772
31MP0000716_abnormal_immune_system1.91246607
32MP0001873_stomach_inflammation1.88962099
33MP0004947_skin_inflammation1.87516838
34MP0010155_abnormal_intestine_physiology1.85146780
35MP0002006_tumorigenesis1.82511790
36MP0009840_abnormal_foam_cell1.81643055
37MP0000689_abnormal_spleen_morphology1.79414316
38MP0004808_abnormal_hematopoietic_stem1.78281302
39MP0009333_abnormal_splenocyte_physiolog1.76843406
40MP0001845_abnormal_inflammatory_respons1.76821626
41MP0002722_abnormal_immune_system1.74446132
42MP0001545_abnormal_hematopoietic_system1.74033605
43MP0005397_hematopoietic_system_phenotyp1.74033605
44MP0001853_heart_inflammation1.66180675
45MP0003724_increased_susceptibility_to1.66126829
46MP0002429_abnormal_blood_cell1.65028685
47MP0001533_abnormal_skeleton_physiology1.64321280
48MP0003183_abnormal_peptide_metabolism1.63982328
49MP0004510_myositis1.63593974
50MP0010352_gastrointestinal_tract_polyps1.62669781
51MP0010307_abnormal_tumor_latency1.60191697
52MP0003191_abnormal_cellular_cholesterol1.46718996
53MP0000858_altered_metastatic_potential1.45333688
54MP0008469_abnormal_protein_level1.42637512
55MP0000703_abnormal_thymus_morphology1.40575981
56MP0005310_abnormal_salivary_gland1.39295572
57MP0002933_joint_inflammation1.38547172
58MP0005174_abnormal_tail_pigmentation1.34645746
59MP0002132_abnormal_respiratory_system1.34073377
60MP0003866_abnormal_defecation1.33320560
61MP0000465_gastrointestinal_hemorrhage1.32612663
62MP0004381_abnormal_hair_follicle1.30280363
63MP0005076_abnormal_cell_differentiation1.28624592
64MP0003448_altered_tumor_morphology1.22476035
65MP0000490_abnormal_crypts_of1.21465773
66MP0004883_abnormal_blood_vessel1.17225310
67MP0000569_abnormal_digit_pigmentation1.13465160
68MP0005023_abnormal_wound_healing1.08119736
69MP0000343_altered_response_to1.07837810
70MP0008004_abnormal_stomach_pH1.06229365
71MP0005164_abnormal_response_to1.05536202
72MP0003690_abnormal_glial_cell1.04460017
73MP0003656_abnormal_erythrocyte_physiolo1.03605265
74MP0001851_eye_inflammation0.98657261
75MP0003075_altered_response_to0.95035225
76MP0009764_decreased_sensitivity_to0.94408706
77MP0003091_abnormal_cell_migration0.93965141
78MP0002019_abnormal_tumor_incidence0.93524395
79MP0003566_abnormal_cell_adhesion0.92924127
80MP0000604_amyloidosis0.92535481
81MP0002998_abnormal_bone_remodeling0.89796939
82MP0000015_abnormal_ear_pigmentation0.86777077
83MP0002277_abnormal_respiratory_mucosa0.84793536
84MP0003693_abnormal_embryo_hatching0.84076450
85MP0000371_diluted_coat_color0.82390546
86MP0000609_abnormal_liver_physiology0.80230991
87MP0003806_abnormal_nucleotide_metabolis0.79565508
88MP0009763_increased_sensitivity_to0.78191528
89MP0002254_reproductive_system_inflammat0.77406814
90MP0002332_abnormal_exercise_endurance0.75343457
91MP0002877_abnormal_melanocyte_morpholog0.75328512
92MP0005166_decreased_susceptibility_to0.74403681
93MP0001663_abnormal_digestive_system0.72500607
94MP0003045_fibrosis0.72384907
95MP0003795_abnormal_bone_structure0.68638946
96MP0000249_abnormal_blood_vessel0.68506325
97MP0002136_abnormal_kidney_physiology0.67717016
98MP0003329_amyloid_beta_deposits0.67526469
99MP0004185_abnormal_adipocyte_glucose0.66880091
100MP0002138_abnormal_hepatobiliary_system0.66031907
101MP0000598_abnormal_liver_morphology0.65324315
102MP0003221_abnormal_cardiomyocyte_apopto0.65130758
103MP0001849_ear_inflammation0.64228133
104MP0000313_abnormal_cell_death0.64062014
105MP0005390_skeleton_phenotype0.63947708
106MP0003705_abnormal_hypodermis_morpholog0.62389539
107MP0003453_abnormal_keratinocyte_physiol0.61768195
108MP0008874_decreased_physiological_sensi0.60747590
109MP0009765_abnormal_xenobiotic_induced0.60252643
110MP0005360_urolithiasis0.59462473
111MP0005075_abnormal_melanosome_morpholog0.59393706
112MP0004858_abnormal_nervous_system0.58998025
113MP0003077_abnormal_cell_cycle0.58962111
114MP0002928_abnormal_bile_duct0.58781544
115MP0003828_pulmonary_edema0.57083997
116MP0009643_abnormal_urine_homeostasis0.56216821
117MP0005319_abnormal_enzyme/_coenzyme0.55421665
118MP0002095_abnormal_skin_pigmentation0.54793827
119MP0002009_preneoplasia0.53934216
120MP0008007_abnormal_cellular_replicative0.53314694
121MP0008873_increased_physiological_sensi0.53279829
122MP0003111_abnormal_nucleus_morphology0.52975587

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.75266621
2Recurrent abscess formation (HP:0002722)5.61799698
3Recurrent bacterial skin infections (HP:0005406)4.92425206
4Myositis (HP:0100614)4.11265177
5Recurrent gram-negative bacterial infections (HP:0005420)4.08583707
6Recurrent fungal infections (HP:0002841)4.02975488
7Elevated erythrocyte sedimentation rate (HP:0003565)3.86163865
8Abnormality of macrophages (HP:0004311)3.83022139
9Recurrent viral infections (HP:0004429)3.66054365
10Vacuolated lymphocytes (HP:0001922)3.63201356
11Nasal polyposis (HP:0100582)3.55632782
12Chronic otitis media (HP:0000389)3.42480837
13Recurrent skin infections (HP:0001581)3.41675780
14Mediastinal lymphadenopathy (HP:0100721)3.36607100
15IgM deficiency (HP:0002850)3.27458316
16Chronic obstructive pulmonary disease (HP:0006510)3.24422325
17Obstructive lung disease (HP:0006536)3.24422325
18Gingivitis (HP:0000230)3.20996114
19Dysostosis multiplex (HP:0000943)3.18990768
20Cellulitis (HP:0100658)3.18028934
21Pustule (HP:0200039)3.15967737
22Orchitis (HP:0100796)3.14167073
23Thrombocytosis (HP:0001894)3.13145430
24Systemic lupus erythematosus (HP:0002725)3.11900804
25Autoimmune thrombocytopenia (HP:0001973)3.10569146
26Abnormality of the nasal mucosa (HP:0000433)3.08163562
27Keratoconjunctivitis (HP:0001096)3.05655777
28Increased cerebral lipofuscin (HP:0011813)3.04480098
29Recurrent bronchitis (HP:0002837)3.04258827
30Petechiae (HP:0000967)3.02431594
31Meningitis (HP:0001287)2.97719315
32Stomatitis (HP:0010280)2.94955590
33Amyloidosis (HP:0011034)2.93049019
34Inflammation of the large intestine (HP:0002037)2.88822689
35Gastrointestinal inflammation (HP:0004386)2.87595370
36Periodontitis (HP:0000704)2.80428892
37Abnormality of B cell number (HP:0010975)2.79963967
38B lymphocytopenia (HP:0010976)2.79963967
39Urinary glycosaminoglycan excretion (HP:0003541)2.78402568
40Mucopolysacchariduria (HP:0008155)2.78402568
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.77754516
42Recurrent cutaneous fungal infections (HP:0011370)2.76894352
43Chronic mucocutaneous candidiasis (HP:0002728)2.76894352
44Retrobulbar optic neuritis (HP:0100654)2.73552540
45Optic neuritis (HP:0100653)2.73552540
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.66307258
47Vasculitis (HP:0002633)2.65966657
48Interstitial pulmonary disease (HP:0006530)2.65256834
49Colitis (HP:0002583)2.61881311
50Thyroiditis (HP:0100646)2.61750581
51Spontaneous hematomas (HP:0007420)2.61448411
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61265532
53Abnormality of polysaccharide metabolism (HP:0011012)2.61265532
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61265532
55Leukocytosis (HP:0001974)2.61015416
56Hypochromic microcytic anemia (HP:0004840)2.58592638
57Increased IgE level (HP:0003212)2.57927790
58Episodic fever (HP:0001954)2.57296738
59Abnormality of T cell physiology (HP:0011840)2.56493185
60Osteomyelitis (HP:0002754)2.54103341
61Abnormal platelet function (HP:0011869)2.53641521
62Impaired platelet aggregation (HP:0003540)2.53641521
63Arterial thrombosis (HP:0004420)2.52908079
64Thoracic kyphosis (HP:0002942)2.48543183
65Increased serum ferritin (HP:0003281)2.48533034
66Hypochromic anemia (HP:0001931)2.48416979
67Panhypogammaglobulinemia (HP:0003139)2.47836581
68Eosinophilia (HP:0001880)2.45074654
69Abnormality of T cells (HP:0002843)2.43864984
70Urticaria (HP:0001025)2.42744514
71Lymphopenia (HP:0001888)2.40494192
72Anorexia (HP:0002039)2.40048944
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.37682221
74Epistaxis (HP:0000421)2.34751466
75Severe combined immunodeficiency (HP:0004430)2.32451820
76Peritonitis (HP:0002586)2.29126021
77Hepatosplenomegaly (HP:0001433)2.28676940
78Hematochezia (HP:0002573)2.28084725
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27610227
80Abnormality of the thoracic spine (HP:0100711)2.26828273
81Pulmonary infiltrates (HP:0002113)2.26322885
82Abnormality of liposaccharide metabolism (HP:0010968)2.23187290
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.23187290
84Abnormality of glycolipid metabolism (HP:0010969)2.23187290
85Granulocytopenia (HP:0001913)2.22867876
86Gingival bleeding (HP:0000225)2.20963397
87Chronic diarrhea (HP:0002028)2.20076831
88Combined immunodeficiency (HP:0005387)2.19153343
89Chest pain (HP:0100749)2.17275989
90Pulmonary embolism (HP:0002204)2.16338254
91Abnormality of iron homeostasis (HP:0011031)2.15968064
92Purpura (HP:0000979)2.15671012
93Prolonged bleeding time (HP:0003010)2.14037003
94Gangrene (HP:0100758)2.11452511
95Abnormality of eosinophils (HP:0001879)2.11020950
96Abnormality of the fingertips (HP:0001211)2.10741863
97T lymphocytopenia (HP:0005403)2.10251652
98Increased IgM level (HP:0003496)2.09167922
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07487979
100Agammaglobulinemia (HP:0004432)2.06949814
101Skin ulcer (HP:0200042)2.06654315
102Osteolytic defects of the phalanges of the hand (HP:0009771)2.05689122
103Osteolytic defects of the hand bones (HP:0009699)2.05689122
104Abnormality of T cell number (HP:0011839)2.05594217
105Disinhibition (HP:0000734)2.04444515
106Myocardial infarction (HP:0001658)2.03159905
107Abnormal platelet volume (HP:0011876)2.03028105
108Encephalitis (HP:0002383)2.01492814
109Polycythemia (HP:0001901)2.00475185
110Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00194890
111Keratoconjunctivitis sicca (HP:0001097)1.99770366
112Recurrent sinusitis (HP:0011108)1.99128033
113Sepsis (HP:0100806)1.99031663
114J-shaped sella turcica (HP:0002680)1.98730792
115Hypergammaglobulinemia (HP:0010702)1.98672213
116Abnormality of the endocardium (HP:0004306)1.98519314
117Abnormality of the pleura (HP:0002103)1.98153948
118Gastrointestinal infarctions (HP:0005244)1.96829519
119Slow saccadic eye movements (HP:0000514)1.96510345
120Fatigue (HP:0012378)1.95886358
121Glomerulopathy (HP:0100820)1.95262029
122Premature loss of primary teeth (HP:0006323)1.95067633
123Loss of speech (HP:0002371)1.95059452
124Hemoptysis (HP:0002105)1.94659224
125Abnormality of the peritoneum (HP:0002585)1.93356710
126Segmental peripheral demyelination/remyelination (HP:0003481)1.92013414
127Malnutrition (HP:0004395)1.90848518
128Cheilitis (HP:0100825)1.87891546
129Acne (HP:0001061)1.87456208
130Viral hepatitis (HP:0006562)1.85202515
131Microcytic anemia (HP:0001935)1.84398544
132Vertigo (HP:0002321)1.83858069
133Neuronal loss in central nervous system (HP:0002529)1.83425734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.43617301
2PRPF4B3.21610942
3ERN12.92298493
4TYK22.57043339
5BLK2.49625741
6STK102.38801406
7ZAP702.37270285
8PKN22.32711380
9TBK12.30160225
10IRAK42.24747067
11EEF2K2.20928956
12TRIB32.17897857
13KIT2.10609206
14TESK21.99684563
15TGFBR21.93791055
16MAP3K101.93649745
17GRK61.93000126
18TESK11.90526140
19JAK31.90211499
20BTK1.88466340
21MAP3K141.84277124
22EPHB11.72103091
23CSF1R1.68735295
24TAOK21.66895202
25TXK1.65135448
26FGR1.63031938
27JAK11.62721385
28IKBKE1.59778788
29MAP2K31.58332367
30SYK1.53001116
31RIPK41.45460023
32SMG11.43516512
33TEC1.39883001
34IKBKB1.39833178
35LRRK21.39113723
36TAOK31.36043361
37HCK1.34701721
38KDR1.33964197
39IRAK21.33560429
40ITK1.32880137
41PTK61.31855521
42CSK1.30967030
43IRAK31.30893011
44SCYL21.30418253
45LCK1.26703743
46FGFR41.23282628
47PIM21.19842341
48SIK31.17753147
49MAP3K111.14524801
50CLK11.14356010
51KSR21.12468631
52IRAK11.11795747
53MAP3K61.09266545
54MARK21.08959163
55TTN1.08876862
56PAK41.08218225
57FES1.08002378
58FLT31.07393310
59PIM11.07010865
60NEK21.06691234
61PRKD21.06086691
62JAK20.99805289
63LYN0.96658444
64RPS6KA40.95993328
65FGFR30.92667558
66TNK20.90092779
67CDK120.88340304
68CDC42BPA0.87946366
69PDPK10.87926069
70CHUK0.85625964
71GRK70.76397005
72MAP3K130.76376691
73ICK0.76236124
74SIK20.73102801
75MAP3K80.71813634
76YES10.69976427
77BMPR20.67590944
78TRPM70.67137007
79MAPK120.64825138
80ALK0.64493421
81MAPK70.62917500
82CDK40.61918715
83TAOK10.60032892
84NME20.58864206
85STK40.58585595
86CDK60.57366559
87MAP3K30.56772181
88PDK10.56397216
89MAP3K70.56173344
90MARK30.54754602
91RPS6KA60.54543996
92MAP3K50.54229476
93MOS0.54113706
94MAPKAPK20.52960330
95BMX0.51460043
96MATK0.50804809
97MAP2K60.50709423
98CAMK1D0.50606513
99PRKG20.48957162
100RPS6KL10.47620383
101RPS6KC10.47620383
102SGK30.47020403
103MAP3K20.46909321
104SIK10.46048380
105MAPK110.45063056
106MAPKAPK30.44112175
107EGFR0.42496569
108PRKCD0.41711494
109PASK0.41064066
110EIF2AK30.39033902
111PIK3CG0.38623036
112MAP2K40.37643833
113ATR0.37293603
114MAPK40.37086978
115RET0.36988454
116DYRK1B0.36758701
117ABL10.35547916
118RPS6KA20.34652114
119NEK90.34306334
120MAP3K10.32557576
121RPS6KA10.32322981
122RPS6KB20.32178976
123PRKCQ0.31933877
124RAF10.28876088
125RIPK10.28622790
126EPHA30.26855365
127PDGFRB0.26634185
128HIPK20.26453299
129FYN0.25549504
130MAP3K120.24795674

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.02089563
2Primary immunodeficiency_Homo sapiens_hsa053402.75605762
3Staphylococcus aureus infection_Homo sapiens_hsa051502.50113720
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.38743616
5B cell receptor signaling pathway_Homo sapiens_hsa046622.36419139
6Other glycan degradation_Homo sapiens_hsa005112.35734841
7Osteoclast differentiation_Homo sapiens_hsa043802.32388449
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.24965635
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14137651
10Antigen processing and presentation_Homo sapiens_hsa046122.06077169
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.01532082
12Measles_Homo sapiens_hsa051621.99180720
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82806007
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.82376465
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82191636
16Lysosome_Homo sapiens_hsa041421.81348630
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79631580
18Hematopoietic cell lineage_Homo sapiens_hsa046401.79365149
19Legionellosis_Homo sapiens_hsa051341.78164929
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63491726
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63406564
22Pertussis_Homo sapiens_hsa051331.61343500
23Tuberculosis_Homo sapiens_hsa051521.60421307
24Autoimmune thyroid disease_Homo sapiens_hsa053201.59443853
25Toxoplasmosis_Homo sapiens_hsa051451.58748984
26Apoptosis_Homo sapiens_hsa042101.50895274
27T cell receptor signaling pathway_Homo sapiens_hsa046601.46387821
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43518033
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.42565503
30Shigellosis_Homo sapiens_hsa051311.42253132
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.39829915
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37207011
33Influenza A_Homo sapiens_hsa051641.35370211
34African trypanosomiasis_Homo sapiens_hsa051431.35079631
35Herpes simplex infection_Homo sapiens_hsa051681.34411883
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32750191
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31717428
38Acute myeloid leukemia_Homo sapiens_hsa052211.30921574
39Chronic myeloid leukemia_Homo sapiens_hsa052201.19555614
40Type I diabetes mellitus_Homo sapiens_hsa049401.19019403
41TNF signaling pathway_Homo sapiens_hsa046681.18687044
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18187376
43Chemokine signaling pathway_Homo sapiens_hsa040621.17310261
44Hepatitis B_Homo sapiens_hsa051611.17005369
45Salmonella infection_Homo sapiens_hsa051321.15469251
46Asthma_Homo sapiens_hsa053101.11754378
47Malaria_Homo sapiens_hsa051441.11651758
48Pentose phosphate pathway_Homo sapiens_hsa000301.08514138
49Caffeine metabolism_Homo sapiens_hsa002321.08473901
50Viral myocarditis_Homo sapiens_hsa054161.00911016
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00687626
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99184578
53Pancreatic cancer_Homo sapiens_hsa052120.98244811
54Platelet activation_Homo sapiens_hsa046110.97268118
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95506914
56Allograft rejection_Homo sapiens_hsa053300.94576609
57Renin-angiotensin system_Homo sapiens_hsa046140.92795865
58Renal cell carcinoma_Homo sapiens_hsa052110.91514988
59Viral carcinogenesis_Homo sapiens_hsa052030.89739635
60DNA replication_Homo sapiens_hsa030300.88162234
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83269392
62Bladder cancer_Homo sapiens_hsa052190.81377808
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.80913099
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80569259
65VEGF signaling pathway_Homo sapiens_hsa043700.79798688
66Phagosome_Homo sapiens_hsa041450.79786947
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76771504
68Hepatitis C_Homo sapiens_hsa051600.75034814
69Small cell lung cancer_Homo sapiens_hsa052220.71648817
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70795419
71Epstein-Barr virus infection_Homo sapiens_hsa051690.69786030
72Endometrial cancer_Homo sapiens_hsa052130.69272316
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.69243516
74Graft-versus-host disease_Homo sapiens_hsa053320.68550881
75GnRH signaling pathway_Homo sapiens_hsa049120.68447830
76Base excision repair_Homo sapiens_hsa034100.67827743
77Non-small cell lung cancer_Homo sapiens_hsa052230.67482701
78Galactose metabolism_Homo sapiens_hsa000520.66142471
79N-Glycan biosynthesis_Homo sapiens_hsa005100.66122867
80FoxO signaling pathway_Homo sapiens_hsa040680.65090460
81HTLV-I infection_Homo sapiens_hsa051660.63693839
82mTOR signaling pathway_Homo sapiens_hsa041500.63243593
83Insulin resistance_Homo sapiens_hsa049310.63030073
84Type II diabetes mellitus_Homo sapiens_hsa049300.61458117
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60788758
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.59896118
87One carbon pool by folate_Homo sapiens_hsa006700.57999635
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56697094
89Non-homologous end-joining_Homo sapiens_hsa034500.55591323
90Choline metabolism in cancer_Homo sapiens_hsa052310.54049117
91HIF-1 signaling pathway_Homo sapiens_hsa040660.53590675
92Endocytosis_Homo sapiens_hsa041440.53305650
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53081755
94Systemic lupus erythematosus_Homo sapiens_hsa053220.52644754
95Sulfur relay system_Homo sapiens_hsa041220.51451784
96ABC transporters_Homo sapiens_hsa020100.50878438
97p53 signaling pathway_Homo sapiens_hsa041150.50629040
98ErbB signaling pathway_Homo sapiens_hsa040120.49481909
99Prolactin signaling pathway_Homo sapiens_hsa049170.49094450
100Selenocompound metabolism_Homo sapiens_hsa004500.48674236
101Amoebiasis_Homo sapiens_hsa051460.48552727
102Fructose and mannose metabolism_Homo sapiens_hsa000510.48063804
103Dorso-ventral axis formation_Homo sapiens_hsa043200.46998327
104Insulin signaling pathway_Homo sapiens_hsa049100.46253670
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46044683
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45534406
107Prostate cancer_Homo sapiens_hsa052150.44794237
108Starch and sucrose metabolism_Homo sapiens_hsa005000.43401138
109MAPK signaling pathway_Homo sapiens_hsa040100.43332102
110Rheumatoid arthritis_Homo sapiens_hsa053230.41129252
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40948260
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39230977
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38312609
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38303350
115Glioma_Homo sapiens_hsa052140.38018681
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.36639153
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.35965358
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35555801
119Complement and coagulation cascades_Homo sapiens_hsa046100.33024696
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.31323224
121Inositol phosphate metabolism_Homo sapiens_hsa005620.31245344
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29990293
123Lysine degradation_Homo sapiens_hsa003100.29774071
124Colorectal cancer_Homo sapiens_hsa052100.29548805
125Notch signaling pathway_Homo sapiens_hsa043300.28995486

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