AP5M1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H2A acetylation (GO:0043968)8.65369535
2phosphate ion transport (GO:0006817)7.26998046
3peptidyl-tyrosine autophosphorylation (GO:0038083)5.48191419
4urate metabolic process (GO:0046415)5.44488479
5phosphate ion transmembrane transport (GO:0035435)5.13478747
6aminoglycoside antibiotic metabolic process (GO:0030647)4.55585013
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.02545128
8negative regulation of heart rate (GO:0010459)4.02073847
9positive regulation of gamma-delta T cell activation (GO:0046645)3.97341132
10tachykinin receptor signaling pathway (GO:0007217)3.90970729
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84889620
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84889620
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.82058131
14presynaptic membrane organization (GO:0097090)3.70451152
15peristalsis (GO:0030432)3.65475940
16iron-sulfur cluster assembly (GO:0016226)3.61378617
17metallo-sulfur cluster assembly (GO:0031163)3.61378617
18negative regulation of cAMP-mediated signaling (GO:0043951)3.61078668
19presynaptic membrane assembly (GO:0097105)3.59042023
20DNA unwinding involved in DNA replication (GO:0006268)3.55785109
21proline transport (GO:0015824)3.55621659
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54762790
23purine-containing compound salvage (GO:0043101)3.53541287
24positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.52975701
25purine nucleobase biosynthetic process (GO:0009113)3.51648403
26transmission of nerve impulse (GO:0019226)3.51068889
27positive regulation of uterine smooth muscle contraction (GO:0070474)3.46419197
28peroxisome fission (GO:0016559)3.46409869
29regulation of gamma-delta T cell differentiation (GO:0045586)3.43730056
30regulation of Golgi to plasma membrane protein transport (GO:0042996)3.43477449
31fatty acid elongation (GO:0030497)3.43369196
32L-methionine salvage (GO:0071267)3.42866861
33L-methionine biosynthetic process (GO:0071265)3.42866861
34amino acid salvage (GO:0043102)3.42866861
35ribosomal small subunit assembly (GO:0000028)3.39457692
36magnesium ion transport (GO:0015693)3.39120803
37regulation of cell communication by electrical coupling (GO:0010649)3.34849844
38regulation of hippo signaling (GO:0035330)3.31778970
39hyperosmotic salinity response (GO:0042538)3.30467545
40photoreceptor cell maintenance (GO:0045494)3.29720054
41antigen processing and presentation of endogenous antigen (GO:0019883)3.21420352
42regulation of RNA export from nucleus (GO:0046831)3.17662915
43chaperone mediated protein folding requiring cofactor (GO:0051085)3.17344326
44histone H4-K12 acetylation (GO:0043983)3.17261387
45DNA strand elongation (GO:0022616)3.16249552
46nucleobase biosynthetic process (GO:0046112)3.15785961
47signal peptide processing (GO:0006465)3.15376948
48Golgi transport vesicle coating (GO:0048200)3.13224208
49COPI coating of Golgi vesicle (GO:0048205)3.13224208
50DNA double-strand break processing (GO:0000729)3.12500321
51oxaloacetate metabolic process (GO:0006107)3.06740570
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05605558
53regulation of mitotic spindle checkpoint (GO:1903504)3.05605558
54nuclear pore complex assembly (GO:0051292)3.05386692
55folic acid metabolic process (GO:0046655)3.04714915
56energy homeostasis (GO:0097009)3.03933310
57protein deneddylation (GO:0000338)3.03880432
58DNA strand elongation involved in DNA replication (GO:0006271)3.02979994
59protein localization to cilium (GO:0061512)3.00412482
60glycoside metabolic process (GO:0016137)2.99842662
61trivalent inorganic anion homeostasis (GO:0072506)2.99001831
62phosphate ion homeostasis (GO:0055062)2.99001831
63response to parathyroid hormone (GO:0071107)2.98314494
64negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.96666203
65regulation of gamma-delta T cell activation (GO:0046643)2.96298882
66positive regulation of B cell differentiation (GO:0045579)2.95732353
67negative regulation of dendrite development (GO:2000171)2.95165842
68glycoprotein catabolic process (GO:0006516)2.94701993
69defense response to protozoan (GO:0042832)2.94378071
70positive regulation of mitochondrial fission (GO:0090141)2.94164620
71intraciliary transport (GO:0042073)2.91764140
72pteridine-containing compound biosynthetic process (GO:0042559)2.89259117
73mitochondrial respiratory chain complex I assembly (GO:0032981)2.88545702
74NADH dehydrogenase complex assembly (GO:0010257)2.88545702
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88545702
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86829109
77detection of calcium ion (GO:0005513)2.84180071
78tricarboxylic acid metabolic process (GO:0072350)2.83169017
79epoxygenase P450 pathway (GO:0019373)2.82656312
80folic acid-containing compound biosynthetic process (GO:0009396)2.82644599
81regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.80973170
82regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.80973170
83photoreceptor cell development (GO:0042461)2.80874475
84response to mercury ion (GO:0046689)2.80438780
85response to lead ion (GO:0010288)2.80243901
86snRNA transcription (GO:0009301)2.79755520
87regulation of nucleobase-containing compound transport (GO:0032239)2.79282418
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.78731784
89regulation of translation, ncRNA-mediated (GO:0045974)2.78731784
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78731784
91negative regulation of DNA recombination (GO:0045910)2.77636408
92negative regulation of protein localization to cell surface (GO:2000009)2.76525837
93response to protozoan (GO:0001562)2.76332395
94C4-dicarboxylate transport (GO:0015740)2.75871155
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75734143
96regulation of dopamine metabolic process (GO:0042053)2.75103649
97regulation of catecholamine metabolic process (GO:0042069)2.75103649
98telomere maintenance via semi-conservative replication (GO:0032201)2.74497688
99NADH metabolic process (GO:0006734)2.72735601
100cellular metabolic compound salvage (GO:0043094)2.72528089
101negative regulation of cell killing (GO:0031342)2.70138416
102negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70138416
103negative regulation of neurological system process (GO:0031645)2.68964659
104cullin deneddylation (GO:0010388)2.67855286
105regulation of isotype switching to IgG isotypes (GO:0048302)2.67838791
106cellular ketone body metabolic process (GO:0046950)2.67287915
107chaperone-mediated protein transport (GO:0072321)2.65992053
108tricarboxylic acid cycle (GO:0006099)2.65718274
109prenylation (GO:0097354)2.65453365
110protein prenylation (GO:0018342)2.65453365
111positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64678912
112positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63481542
113positive regulation of heart rate (GO:0010460)2.63464471
114positive regulation of histone H3-K4 methylation (GO:0051571)2.63361767
115methionine biosynthetic process (GO:0009086)2.63268970
116mitotic G2 DNA damage checkpoint (GO:0007095)2.59991909
117striatum development (GO:0021756)2.59644984
118histone mRNA metabolic process (GO:0008334)2.58341827
119UDP-N-acetylglucosamine metabolic process (GO:0006047)2.57392940
120daunorubicin metabolic process (GO:0044597)2.57102672
121polyketide metabolic process (GO:0030638)2.57102672
122doxorubicin metabolic process (GO:0044598)2.57102672
123positive regulation of action potential (GO:0045760)2.56640734
124histone exchange (GO:0043486)2.56079285
125DNA deamination (GO:0045006)2.54972736
126lysine catabolic process (GO:0006554)2.54580650
127lysine metabolic process (GO:0006553)2.54580650
128regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54244535
129deoxyribose phosphate biosynthetic process (GO:0046385)2.53555649
1302-deoxyribonucleotide biosynthetic process (GO:0009265)2.53555649
131response to pheromone (GO:0019236)2.53377635
132methionine metabolic process (GO:0006555)2.53058160
133indole-containing compound metabolic process (GO:0042430)2.52868501
134negative T cell selection (GO:0043383)2.52777557
135serine family amino acid biosynthetic process (GO:0009070)2.52553256
136mitotic G2/M transition checkpoint (GO:0044818)2.52203047
137nuclear pore organization (GO:0006999)2.51852103
138regulation of acyl-CoA biosynthetic process (GO:0050812)2.51245321
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50169212
140positive regulation of signal transduction by p53 class mediator (GO:1901798)2.49791329
141regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.48863665
142coenzyme A metabolic process (GO:0015936)2.48337171
143telomere maintenance via recombination (GO:0000722)2.47546312
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.47356346
145protoporphyrinogen IX metabolic process (GO:0046501)2.46655673
146glycine metabolic process (GO:0006544)2.46567532
147intra-S DNA damage checkpoint (GO:0031573)2.46557370
148cellular response to ammonium ion (GO:0071242)2.46545029
149regulation of helicase activity (GO:0051095)2.45645130
150sulfur amino acid biosynthetic process (GO:0000097)2.45143016
151erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45129523
152L-phenylalanine catabolic process (GO:0006559)2.45129523
153negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44954069
154valine metabolic process (GO:0006573)2.44912615
155eye photoreceptor cell development (GO:0042462)2.42839614
156histone H4 acetylation (GO:0043967)2.42186137
157synapsis (GO:0007129)2.41909849
158necroptotic process (GO:0070266)2.41758926
159replication fork processing (GO:0031297)2.41341888
160negative regulation of DNA repair (GO:0045738)2.40987923
161parental behavior (GO:0060746)2.40775047
162short-chain fatty acid metabolic process (GO:0046459)2.40719291
163ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.40216183
164nucleoside bisphosphate biosynthetic process (GO:0033866)2.40216183
165purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.40216183
166reflex (GO:0060004)2.39746287
167CENP-A containing nucleosome assembly (GO:0034080)2.39682998
168protoporphyrinogen IX biosynthetic process (GO:0006782)2.38760339
169negative thymic T cell selection (GO:0045060)2.38719072
170chromatin remodeling at centromere (GO:0031055)2.38647844
171regulation of B cell differentiation (GO:0045577)2.38574562
172purine nucleobase metabolic process (GO:0006144)2.38070969
173nucleoside salvage (GO:0043174)2.38016382
174detection of light stimulus involved in sensory perception (GO:0050962)2.37897651
175detection of light stimulus involved in visual perception (GO:0050908)2.37897651
176IMP metabolic process (GO:0046040)2.37347585
177acyl-CoA biosynthetic process (GO:0071616)2.37210207
178thioester biosynthetic process (GO:0035384)2.37210207
179succinate metabolic process (GO:0006105)2.37044039
180mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.36082057
181L-fucose catabolic process (GO:0042355)2.35769665
182fucose catabolic process (GO:0019317)2.35769665
183L-fucose metabolic process (GO:0042354)2.35769665
184regulation of B cell receptor signaling pathway (GO:0050855)2.35617604
185behavioral response to nicotine (GO:0035095)2.35312970
186regulation of pigment cell differentiation (GO:0050932)2.35310287
187regulation of relaxation of muscle (GO:1901077)2.34689274
188behavioral response to ethanol (GO:0048149)2.34434753
189adult heart development (GO:0007512)2.33914358
190DNA replication initiation (GO:0006270)2.33531223
191telomere organization (GO:0032200)2.33103554
192cilium morphogenesis (GO:0060271)2.33033099
193regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.32497604
194antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.32038806
195fatty-acyl-CoA metabolic process (GO:0035337)2.31652545
196purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.31365353
197neuronal action potential (GO:0019228)2.31263690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.53799247
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.33486288
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.25835902
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25371099
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.12642509
6GBX2_23144817_ChIP-Seq_PC3_Human2.98589173
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97223685
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.92545547
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89243640
10FUS_26573619_Chip-Seq_HEK293_Human2.85990114
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.77175150
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75674206
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68802604
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.67249870
15ZNF274_21170338_ChIP-Seq_K562_Hela2.67079740
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.61541452
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.52500655
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51511327
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49984717
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49641064
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.44244172
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.41662534
23VDR_23849224_ChIP-Seq_CD4+_Human2.35807354
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35581530
25IGF1R_20145208_ChIP-Seq_DFB_Human2.29557949
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.23352318
27HOXB4_20404135_ChIP-ChIP_EML_Mouse2.21563173
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21065055
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.20457193
30ERG_20887958_ChIP-Seq_HPC-7_Mouse2.15136367
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14422103
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14242787
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.14172761
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12953634
35GATA1_22025678_ChIP-Seq_K562_Human2.10703192
36VDR_22108803_ChIP-Seq_LS180_Human2.09839873
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06981571
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06299374
39MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06156300
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04679358
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04575548
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02698659
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01966172
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00442052
45FOXP3_21729870_ChIP-Seq_TREG_Human1.99578637
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97804217
47P300_19829295_ChIP-Seq_ESCs_Human1.97650913
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96485325
49TAF15_26573619_Chip-Seq_HEK293_Human1.96280177
50EWS_26573619_Chip-Seq_HEK293_Human1.95831583
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.95417277
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90435407
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90328070
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90174983
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89607015
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.87965087
57AR_21909140_ChIP-Seq_LNCAP_Human1.87266359
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87065920
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85292719
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79760908
61XRN2_22483619_ChIP-Seq_HELA_Human1.78144837
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77198806
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.72811823
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72749417
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72729620
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71798531
67GABP_19822575_ChIP-Seq_HepG2_Human1.69955296
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67890973
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67798359
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65749111
71SMAD4_21799915_ChIP-Seq_A2780_Human1.65165861
72DCP1A_22483619_ChIP-Seq_HELA_Human1.64851895
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64778214
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.64093828
75ER_23166858_ChIP-Seq_MCF-7_Human1.63807520
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63595100
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63092121
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61977327
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.61308339
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59939834
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59346697
82STAT3_23295773_ChIP-Seq_U87_Human1.59166438
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58272951
84CIITA_25753668_ChIP-Seq_RAJI_Human1.58067555
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.56978187
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.55389877
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.52708325
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50891604
89MYB_26560356_Chip-Seq_TH2_Human1.50860396
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50779129
91ELK1_19687146_ChIP-ChIP_HELA_Human1.49759222
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49746482
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49596310
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49433692
95MYC_22102868_ChIP-Seq_BL_Human1.49210429
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47585746
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46884399
98SPI1_23547873_ChIP-Seq_NB4_Human1.46311108
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.44458378
100STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44065736
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43596794
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43117196
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.42196931
104SCL_19346495_ChIP-Seq_HPC-7_Human1.41154382
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41032203
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40965616
107MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40694585
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40463320
109AR_25329375_ChIP-Seq_VCAP_Human1.40369360
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38161601
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37027088
112FOXM1_23109430_ChIP-Seq_U2OS_Human1.36907287
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.36324625
114P53_22387025_ChIP-Seq_ESCs_Mouse1.36148385
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35825222
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34886358
117P300_18555785_Chip-Seq_ESCs_Mouse1.34210455
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32674820
119EZH2_22144423_ChIP-Seq_EOC_Human1.32192652
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31491088
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.29662268
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28748299
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26955770
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26579039
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25295584
126WT1_19549856_ChIP-ChIP_CCG9911_Human1.25054909
127BCAT_22108803_ChIP-Seq_LS180_Human1.24619384
128TCF4_22108803_ChIP-Seq_LS180_Human1.23773980
129MYB_26560356_Chip-Seq_TH1_Human1.23148056
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.23125527
131CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22702724
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.22070011
133E2F1_21310950_ChIP-Seq_MCF-7_Human1.21184051
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21134173
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20782599
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.19926965
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19102442
138SOX2_18555785_Chip-Seq_ESCs_Mouse1.18589240
139MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17625717
140RUNX2_22187159_ChIP-Seq_PCA_Human1.16962001
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16733884
142KDM5A_27292631_Chip-Seq_BREAST_Human1.14951673
143TTF2_22483619_ChIP-Seq_HELA_Human1.14830851
144MYC_18940864_ChIP-ChIP_HL60_Human1.14812381
145OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14748053
146VDR_21846776_ChIP-Seq_THP-1_Human1.14331837
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13368249
148CBP_20019798_ChIP-Seq_JUKART_Human1.13368249
149TFEB_21752829_ChIP-Seq_HELA_Human1.12946471
150FLI1_21867929_ChIP-Seq_TH2_Mouse1.12198694
151SMAD4_21741376_ChIP-Seq_EPCs_Human1.11991895
152EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11868131
153RXR_22158963_ChIP-Seq_LIVER_Mouse1.11746597
154RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10930861
155ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10377781
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10111031
157TCF4_23295773_ChIP-Seq_U87_Human1.10092320
158FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09802998
159PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09140456
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08458308
161SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07646406
162GATA3_27048872_Chip-Seq_THYMUS_Human1.07289877
163OCT4_18555785_Chip-Seq_ESCs_Mouse1.07091212
164CDX2_22108803_ChIP-Seq_LS180_Human1.06561669
165GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05370389
166PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05149695
167GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05142134
168MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04399226
169NMYC_18555785_Chip-Seq_ESCs_Mouse1.04036933
170SOX2_19829295_ChIP-Seq_ESCs_Human1.03598025
171NANOG_19829295_ChIP-Seq_ESCs_Human1.03598025
172FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02091903
173SOX2_21211035_ChIP-Seq_LN229_Gbm1.01612071
174FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01273034
175STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01120358
176STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00245455
177RUNX_20019798_ChIP-Seq_JUKART_Human1.00231827
178GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00186584
179PU1_27457419_Chip-Seq_LIVER_Mouse0.98365825
180TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98279645
181MAF_26560356_Chip-Seq_TH1_Human0.97896080
182TAL1_26923725_Chip-Seq_HPCs_Mouse0.97877000
183RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97538469
184CTCF_18555785_Chip-Seq_ESCs_Mouse0.97345482
185RUNX1_22412390_ChIP-Seq_EML_Mouse0.96595339
186E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96226152
187NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95818479
188POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95572680
189CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95392303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.65605632
2MP0002139_abnormal_hepatobiliary_system3.27712278
3MP0005671_abnormal_response_to3.22423531
4MP0003880_abnormal_central_pattern3.15946252
5MP0003890_abnormal_embryonic-extraembry2.94488404
6MP0001984_abnormal_olfaction2.82572376
7MP0005365_abnormal_bile_salt2.80948416
8MP0002396_abnormal_hematopoietic_system2.56497062
9MP0003763_abnormal_thymus_physiology2.55932356
10MP0008877_abnormal_DNA_methylation2.55163190
11MP0004215_abnormal_myocardial_fiber2.54978820
12MP0005360_urolithiasis2.48359468
13MP0005645_abnormal_hypothalamus_physiol2.44408456
14MP0001485_abnormal_pinna_reflex2.34525730
15MP0000427_abnormal_hair_cycle2.28329144
16MP0002822_catalepsy2.28274428
17MP0003656_abnormal_erythrocyte_physiolo2.23012045
18MP0004957_abnormal_blastocyst_morpholog2.13709797
19MP0001873_stomach_inflammation2.12676280
20MP0001486_abnormal_startle_reflex2.09308114
21MP0002166_altered_tumor_susceptibility2.06953060
22MP0006072_abnormal_retinal_apoptosis2.05760911
23MP0001835_abnormal_antigen_presentation2.02469691
24MP0002398_abnormal_bone_marrow2.01340019
25MP0001800_abnormal_humoral_immune2.00650746
26MP0010094_abnormal_chromosome_stability1.99880467
27MP0005551_abnormal_eye_electrophysiolog1.99555172
28MP0005083_abnormal_biliary_tract1.97828874
29MP0002102_abnormal_ear_morphology1.96504518
30MP0008875_abnormal_xenobiotic_pharmacok1.95815595
31MP0006276_abnormal_autonomic_nervous1.92355007
32MP0000685_abnormal_immune_system1.91519972
33MP0009785_altered_susceptibility_to1.90094304
34MP0003693_abnormal_embryo_hatching1.89294425
35MP0000516_abnormal_urinary_system1.86513567
36MP0005367_renal/urinary_system_phenotyp1.86513567
37MP0001529_abnormal_vocalization1.86253586
38MP0005377_hearing/vestibular/ear_phenot1.83207595
39MP0003878_abnormal_ear_physiology1.83207595
40MP0006054_spinal_hemorrhage1.83080336
41MP0005085_abnormal_gallbladder_physiolo1.83075258
42MP0004147_increased_porphyrin_level1.80756909
43MP0005253_abnormal_eye_physiology1.79815362
44MP0002723_abnormal_immune_serum1.79358534
45MP0002420_abnormal_adaptive_immunity1.78978599
46MP0001819_abnormal_immune_cell1.75530254
47MP0003186_abnormal_redox_activity1.75294621
48MP0006036_abnormal_mitochondrial_physio1.74443107
49MP0000689_abnormal_spleen_morphology1.71661729
50MP0005075_abnormal_melanosome_morpholog1.71647363
51MP0005000_abnormal_immune_tolerance1.69320891
52MP0000716_abnormal_immune_system1.65165313
53MP0003941_abnormal_skin_development1.64696004
54MP0009333_abnormal_splenocyte_physiolog1.62387623
55MP0003077_abnormal_cell_cycle1.61530428
56MP0002722_abnormal_immune_system1.61479187
57MP0002452_abnormal_antigen_presenting1.59082190
58MP0002132_abnormal_respiratory_system1.58332766
59MP0001501_abnormal_sleep_pattern1.56160287
60MP0009046_muscle_twitch1.55837210
61MP0002332_abnormal_exercise_endurance1.55385535
62MP0002429_abnormal_blood_cell1.54647961
63MP0000465_gastrointestinal_hemorrhage1.52401885
64MP0008057_abnormal_DNA_replication1.52111323
65MP0005025_abnormal_response_to1.50644255
66MP0006082_CNS_inflammation1.50066668
67MP0008775_abnormal_heart_ventricle1.47119136
68MP0010678_abnormal_skin_adnexa1.46212759
69MP0004085_abnormal_heartbeat1.45514114
70MP0009697_abnormal_copulation1.44996338
71MP0010155_abnormal_intestine_physiology1.44600972
72MP0005464_abnormal_platelet_physiology1.44261610
73MP0000490_abnormal_crypts_of1.42170777
74MP0010386_abnormal_urinary_bladder1.39226627
75MP0003866_abnormal_defecation1.39091892
76MP0000703_abnormal_thymus_morphology1.38057492
77MP0003436_decreased_susceptibility_to1.37181924
78MP0005310_abnormal_salivary_gland1.36932337
79MP0004510_myositis1.36158191
80MP0003137_abnormal_impulse_conducting1.35156132
81MP0000383_abnormal_hair_follicle1.32784077
82MP0004484_altered_response_of1.31021758
83MP0003787_abnormal_imprinting1.30751803
84MP0000609_abnormal_liver_physiology1.29295728
85MP0002638_abnormal_pupillary_reflex1.28896698
86MP0002735_abnormal_chemical_nociception1.27942116
87MP0003183_abnormal_peptide_metabolism1.27869473
88MP0002419_abnormal_innate_immunity1.27827860
89MP0001764_abnormal_homeostasis1.27681701
90MP0005084_abnormal_gallbladder_morpholo1.27184922
91MP0002160_abnormal_reproductive_system1.26181811
92MP0004808_abnormal_hematopoietic_stem1.25480623
93MP0009745_abnormal_behavioral_response1.24580643
94MP0004019_abnormal_vitamin_homeostasis1.24469797
95MP0000749_muscle_degeneration1.23778411
96MP0000604_amyloidosis1.23224001
97MP0001666_abnormal_nutrient_absorption1.22763860
98MP0003943_abnormal_hepatobiliary_system1.22413155
99MP0004947_skin_inflammation1.21938561
100MP0001845_abnormal_inflammatory_respons1.21809143
101MP0003635_abnormal_synaptic_transmissio1.21089281
102MP0002006_tumorigenesis1.20122303
103MP0001790_abnormal_immune_system1.19967166
104MP0005387_immune_system_phenotype1.19967166
105MP0009672_abnormal_birth_weight1.19733565
106MP0005584_abnormal_enzyme/coenzyme_acti1.19180622
107MP0008058_abnormal_DNA_repair1.19079766
108MP0009840_abnormal_foam_cell1.18031800
109MP0002272_abnormal_nervous_system1.17250969
110MP0010234_abnormal_vibrissa_follicle1.16392327
111MP0003123_paternal_imprinting1.14403404
112MP0000778_abnormal_nervous_system1.12513224
113MP0008469_abnormal_protein_level1.12047525
114MP0003724_increased_susceptibility_to1.11872700
115MP0005220_abnormal_exocrine_pancreas1.11018761
116MP0010329_abnormal_lipoprotein_level1.10909781
117MP0003252_abnormal_bile_duct1.10296558
118MP0002734_abnormal_mechanical_nocicepti1.10183067
119MP0002063_abnormal_learning/memory/cond1.09839506
120MP0003136_yellow_coat_color1.09732688
121MP0005332_abnormal_amino_acid1.09582638
122MP0000569_abnormal_digit_pigmentation1.09386952
123MP0004145_abnormal_muscle_electrophysio1.09214746
124MP0002019_abnormal_tumor_incidence1.08927210
125MP0002837_dystrophic_cardiac_calcinosis1.08570524
126MP0002405_respiratory_system_inflammati1.08350718
127MP0005248_abnormal_Harderian_gland1.07662915
128MP0001545_abnormal_hematopoietic_system1.07226330
129MP0005397_hematopoietic_system_phenotyp1.07226330
130MP0009643_abnormal_urine_homeostasis1.05783957
131MP0003172_abnormal_lysosome_physiology1.04277730
132MP0002148_abnormal_hypersensitivity_rea1.04276880
133MP0002067_abnormal_sensory_capabilities1.03745970
134MP0005195_abnormal_posterior_eye1.03390896
135MP0002138_abnormal_hepatobiliary_system1.03220555
136MP0003329_amyloid_beta_deposits1.01452031
137MP0004924_abnormal_behavior1.01177984
138MP0005386_behavior/neurological_phenoty1.01177984
139MP0005266_abnormal_metabolism1.00335213
140MP0001177_atelectasis1.00074210
141MP0000598_abnormal_liver_morphology0.99809143
142MP0005636_abnormal_mineral_homeostasis0.99611983
143MP0002751_abnormal_autonomic_nervous0.98990113
144MP0003191_abnormal_cellular_cholesterol0.98692347
145MP0005499_abnormal_olfactory_system0.98601427
146MP0005394_taste/olfaction_phenotype0.98601427
147MP0001293_anophthalmia0.98249457
148MP0002184_abnormal_innervation0.96500246
149MP0002064_seizures0.96187825
150MP0000538_abnormal_urinary_bladder0.96122774
151MP0001853_heart_inflammation0.95337891
152MP0004270_analgesia0.94581841
153MP0005319_abnormal_enzyme/_coenzyme0.94018429
154MP0005058_abnormal_lysosome_morphology0.93780038
155MP0002752_abnormal_somatic_nervous0.92729973
156MP0002095_abnormal_skin_pigmentation0.92261738
157MP0002572_abnormal_emotion/affect_behav0.91053713
158MP0004133_heterotaxia0.90888478
159MP0001730_embryonic_growth_arrest0.89532849
160MP0001663_abnormal_digestive_system0.89266416
161MP0006035_abnormal_mitochondrial_morpho0.86702097
162MP0002933_joint_inflammation0.85654292
163MP0002229_neurodegeneration0.85503849
164MP0000372_irregular_coat_pigmentation0.85371620
165MP0000350_abnormal_cell_proliferation0.85287273
166MP0003567_abnormal_fetal_cardiomyocyte0.85275155
167MP0005187_abnormal_penis_morphology0.84286306
168MP0002733_abnormal_thermal_nociception0.82380848
169MP0003111_abnormal_nucleus_morphology0.82352222
170MP0003195_calcinosis0.82025256
171MP0008789_abnormal_olfactory_epithelium0.79624910
172MP0010352_gastrointestinal_tract_polyps0.78528846
173MP0002090_abnormal_vision0.78374678
174MP0009703_decreased_birth_body0.77275834
175MP0002069_abnormal_eating/drinking_beha0.74661408
176MP0001963_abnormal_hearing_physiology0.74617552
177MP0005389_reproductive_system_phenotype0.74497682
178MP0000647_abnormal_sebaceous_gland0.73278086
179MP0002928_abnormal_bile_duct0.73249235

Predicted human phenotypes

RankGene SetZ-score
1Proximal tubulopathy (HP:0000114)5.80472627
2Renal cortical cysts (HP:0000803)4.20502007
3IgM deficiency (HP:0002850)4.08929280
4Thrombocytosis (HP:0001894)3.78722269
5Hypoplasia of the thymus (HP:0000778)3.71981360
6Increased serum pyruvate (HP:0003542)3.55486175
7Abnormality of glycolysis (HP:0004366)3.55486175
8Pendular nystagmus (HP:0012043)3.53456101
9True hermaphroditism (HP:0010459)3.51345337
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.49749706
11T lymphocytopenia (HP:0005403)3.43346264
12Pancreatic fibrosis (HP:0100732)3.38742179
13Pancreatic cysts (HP:0001737)3.30054617
14Abnormality of B cell number (HP:0010975)3.29636180
15B lymphocytopenia (HP:0010976)3.29636180
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.27266407
17Abnormality of T cell number (HP:0011839)3.26267752
18Recurrent bronchitis (HP:0002837)3.17408285
19Glycosuria (HP:0003076)2.99222234
20Abnormality of urine glucose concentration (HP:0011016)2.99222234
21Severe combined immunodeficiency (HP:0004430)2.95424641
22Chronic otitis media (HP:0000389)2.94528215
23Fatigue (HP:0012378)2.93885220
24Abnormality of the vitamin B12 metabolism (HP:0004341)2.93508059
25Abnormality of vitamin B metabolism (HP:0004340)2.91558741
26Severe visual impairment (HP:0001141)2.91180268
27Thyroiditis (HP:0100646)2.90360476
28Myokymia (HP:0002411)2.83220555
29Combined immunodeficiency (HP:0005387)2.81868675
30Abolished electroretinogram (ERG) (HP:0000550)2.81135368
31Abnormality of T cells (HP:0002843)2.73742702
32Hepatic necrosis (HP:0002605)2.71647622
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71613020
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71613020
35Elevated erythrocyte sedimentation rate (HP:0003565)2.69966041
36Neuroendocrine neoplasm (HP:0100634)2.67302977
37Congenital primary aphakia (HP:0007707)2.66956303
38Gait imbalance (HP:0002141)2.66718607
39Hypobetalipoproteinemia (HP:0003563)2.66637017
40Congenital stationary night blindness (HP:0007642)2.65900873
41Hepatocellular necrosis (HP:0001404)2.65185724
42Birth length less than 3rd percentile (HP:0003561)2.61656171
43IgG deficiency (HP:0004315)2.57498304
44Genital tract atresia (HP:0001827)2.55022330
45Abnormality of the renal cortex (HP:0011035)2.55005164
46Intrahepatic cholestasis (HP:0001406)2.54486887
47Popliteal pterygium (HP:0009756)2.53604975
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50772576
49Vaginal atresia (HP:0000148)2.47820896
50Pustule (HP:0200039)2.47422563
51Medial flaring of the eyebrow (HP:0010747)2.47077285
52Pheochromocytoma (HP:0002666)2.46698970
53Abnormality of fatty-acid metabolism (HP:0004359)2.45869078
54Hyperbilirubinemia (HP:0002904)2.45638749
55Abnormality of macular pigmentation (HP:0008002)2.43234848
56Agnosia (HP:0010524)2.41786277
57Cystic hygroma (HP:0000476)2.40129774
58Abnormality of the pons (HP:0007361)2.39453204
59Hyperkalemia (HP:0002153)2.39373516
60Postnatal microcephaly (HP:0005484)2.39247458
61Nephrogenic diabetes insipidus (HP:0009806)2.37517822
62Ketosis (HP:0001946)2.36800408
63Abnormality of chromosome stability (HP:0003220)2.36029684
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.34486603
65Impaired vibration sensation in the lower limbs (HP:0002166)2.32607010
66Cellular immunodeficiency (HP:0005374)2.31378493
67Poor head control (HP:0002421)2.31166675
68Petechiae (HP:0000967)2.29207499
69Acanthocytosis (HP:0001927)2.27526686
70Abnormality of eosinophils (HP:0001879)2.25944886
71Postaxial foot polydactyly (HP:0001830)2.25466333
72Abnormal number of erythroid precursors (HP:0012131)2.24658871
73Abnormal mitochondria in muscle tissue (HP:0008316)2.21420816
74Fair hair (HP:0002286)2.19737815
75Lymphoma (HP:0002665)2.19102962
76Acute lymphatic leukemia (HP:0006721)2.18784037
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.17856180
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17856180
79Conjugated hyperbilirubinemia (HP:0002908)2.17276373
80Optic nerve hypoplasia (HP:0000609)2.16532865
81Cerebral edema (HP:0002181)2.15528483
82Pancreatic islet-cell hyperplasia (HP:0004510)2.14936353
83Panhypogammaglobulinemia (HP:0003139)2.13867706
84Progressive inability to walk (HP:0002505)2.13115635
85Hyperphosphaturia (HP:0003109)2.12783642
86Recurrent viral infections (HP:0004429)2.12538590
87Rough bone trabeculation (HP:0100670)2.12456794
88Hypoplasia of the pons (HP:0012110)2.12023991
89Abnormality of cells of the erythroid lineage (HP:0012130)2.11759601
90Bronchitis (HP:0012387)2.11708575
91Abnormality of T cell physiology (HP:0011840)2.11248196
92Lactic acidosis (HP:0003128)2.09857072
93Reticulocytopenia (HP:0001896)2.09631975
94Abnormality of the labia minora (HP:0012880)2.08144279
95IgA deficiency (HP:0002720)2.06081182
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06074060
97Dyschromatopsia (HP:0007641)2.05989459
98Reduced antithrombin III activity (HP:0001976)2.03951205
99Lymphopenia (HP:0001888)2.03508533
100Aplastic anemia (HP:0001915)2.03309920
101Gout (HP:0001997)2.03190656
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03004817
103Gonadotropin excess (HP:0000837)2.02894134
104Generalized aminoaciduria (HP:0002909)2.02011142
105Chronic hepatic failure (HP:0100626)2.01621430
106Abnormality of homocysteine metabolism (HP:0010919)2.00822998
107Homocystinuria (HP:0002156)2.00822998
108Cystic liver disease (HP:0006706)2.00754778
109Dicarboxylic aciduria (HP:0003215)2.00500302
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00500302
111Intestinal atresia (HP:0011100)2.00348319
112Focal seizures (HP:0007359)2.00044651
113Abnormal protein glycosylation (HP:0012346)1.99789160
114Abnormal glycosylation (HP:0012345)1.99789160
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99789160
116Abnormal protein N-linked glycosylation (HP:0012347)1.99789160
117Mitochondrial inheritance (HP:0001427)1.99194577
118Cerebral hypomyelination (HP:0006808)1.98487708
119Abnormality of the intrinsic pathway (HP:0010989)1.98398586
120Thyroid carcinoma (HP:0002890)1.98120857
1213-Methylglutaconic aciduria (HP:0003535)1.97707183
122Furrowed tongue (HP:0000221)1.97702821
123Abnormality of the corticospinal tract (HP:0002492)1.96962290
124Hypoglycemic coma (HP:0001325)1.95910812
125Acute necrotizing encephalopathy (HP:0006965)1.95817786
126Epiphyseal stippling (HP:0010655)1.95524043
127Poor coordination (HP:0002370)1.95274881
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.95267321
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93190465
130Prolonged partial thromboplastin time (HP:0003645)1.93137587
131Abnormal biliary tract physiology (HP:0012439)1.93068728
132Bile duct proliferation (HP:0001408)1.93068728
133Abnormal auditory evoked potentials (HP:0006958)1.92713704
134Genetic anticipation (HP:0003743)1.92568924
135Neurodegeneration (HP:0002180)1.91789072
136Abnormality of vitamin metabolism (HP:0100508)1.91780529
137Methylmalonic acidemia (HP:0002912)1.90706842
138Increased CSF lactate (HP:0002490)1.90517713
139Specific learning disability (HP:0001328)1.90301724
140Gastrointestinal stroma tumor (HP:0100723)1.89998484
141Neutropenia (HP:0001875)1.89764374
142Amniotic constriction ring (HP:0009775)1.89653548
143Abnormality of placental membranes (HP:0011409)1.89653548
144Fat malabsorption (HP:0002630)1.89362241
145Neoplasm of the peripheral nervous system (HP:0100007)1.89231875
146Progressive cerebellar ataxia (HP:0002073)1.89161711
147Ketoacidosis (HP:0001993)1.88794139
148Fetal akinesia sequence (HP:0001989)1.88599643
149Long clavicles (HP:0000890)1.88527438
150Neoplasm of the adrenal gland (HP:0100631)1.88406522
151Cerebral hemorrhage (HP:0001342)1.87509045
152Attenuation of retinal blood vessels (HP:0007843)1.87029804
153Focal motor seizures (HP:0011153)1.85501354
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.85484389
155Diastasis recti (HP:0001540)1.84741385
156Acute encephalopathy (HP:0006846)1.83854028
157Lethargy (HP:0001254)1.83740783
158Urinary urgency (HP:0000012)1.83613195
159Abnormality of serum amino acid levels (HP:0003112)1.83440357
160Drooling (HP:0002307)1.83393431
161Brushfield spots (HP:0001088)1.82235309
162Epistaxis (HP:0000421)1.81898598
163Sclerocornea (HP:0000647)1.81518688
164Aqueductal stenosis (HP:0002410)1.81497737
165Abnormality of the labia majora (HP:0012881)1.81316151
166Postaxial hand polydactyly (HP:0001162)1.81109183
167Recurrent abscess formation (HP:0002722)1.80887375
168Broad-based gait (HP:0002136)1.80531386
169Gaze-evoked nystagmus (HP:0000640)1.79933045
170Congenital hepatic fibrosis (HP:0002612)1.79800590
171Abnormality of the common coagulation pathway (HP:0010990)1.78731298
172Hypothermia (HP:0002045)1.78394727
173Pancytopenia (HP:0001876)1.78217156
174Anencephaly (HP:0002323)1.77807258
175Action tremor (HP:0002345)1.77674137
176Nephronophthisis (HP:0000090)1.76680149
177Chorioretinal atrophy (HP:0000533)1.76436592
178Spastic diplegia (HP:0001264)1.75726688
179Granulocytopenia (HP:0001913)1.75611930
180Steatorrhea (HP:0002570)1.75237865
181Abnormality of methionine metabolism (HP:0010901)1.75065097
182Febrile seizures (HP:0002373)1.74957506
183Cortical dysplasia (HP:0002539)1.74045872
184Increased serum lactate (HP:0002151)1.73971121
185Impaired vibratory sensation (HP:0002495)1.73619652
186Dialeptic seizures (HP:0011146)1.73598115
187Decreased testicular size (HP:0008734)1.71722307
188Abnormality of the renal medulla (HP:0100957)1.70687894
189Hyperventilation (HP:0002883)1.69191009
190Colon cancer (HP:0003003)1.68270139
191Excessive salivation (HP:0003781)1.65356371
192Inability to walk (HP:0002540)1.64709626
193Preaxial hand polydactyly (HP:0001177)1.64122848
194Decreased circulating renin level (HP:0003351)1.62600444
195Decreased central vision (HP:0007663)1.61705627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK5.93404749
2FRK5.09638562
3STK163.69099837
4TRIM283.31881454
5WEE13.27064486
6BCKDK3.02715896
7CDK192.89792461
8MAP4K12.78059021
9BRSK22.43264470
10WNK32.31007240
11MST42.08643131
12FGFR22.08530584
13SCYL22.04128405
14EIF2AK11.97777099
15PBK1.96438317
16BMPR1B1.93692954
17PLK31.90867344
18OBSCN1.83074418
19MAP3K121.79790295
20ACVR1B1.79619898
21CCNB11.77922598
22FLT31.77320458
23TXK1.75061510
24LIMK11.70678010
25BUB11.69097333
26CASK1.65989494
27STK101.64535198
28MAP3K41.64519951
29KIT1.62819032
30BRSK11.59019325
31CAMKK11.57329166
32ADRBK21.56281115
33ZAK1.55455362
34BTK1.47947320
35MAPKAPK51.46974835
36PLK41.46257745
37SRPK11.44299476
38OXSR11.42417275
39ITK1.34777687
40ERN11.34306597
41TESK21.33326715
42NEK11.28671156
43PLK21.28048322
44SYK1.27596394
45VRK11.25242207
46RPS6KA41.24477172
47NEK91.22643764
48MAPK131.22381791
49GRK71.18518737
50TGFBR21.18340007
51TEC1.17036353
52ZAP701.16485411
53MAP4K21.16318710
54TSSK61.13368972
55LRRK21.12653301
56MAP2K71.10123107
57CSF1R1.08478497
58CAMKK21.07706973
59TYK21.02673819
60TNIK1.00582592
61GRK60.98805720
62INSRR0.98728781
63TBK10.98468570
64EPHA30.95652710
65TGFBR10.94880936
66MAP3K140.94731253
67PRKCE0.94275821
68STK38L0.88278957
69EEF2K0.87491903
70CSNK1G10.84833706
71LCK0.84752012
72TYRO30.80648275
73NTRK30.80614738
74AKT30.80324847
75LYN0.80003620
76PKN20.79945730
77CSNK1G20.79177681
78TTK0.77561555
79SIK30.75859703
80NLK0.75501148
81BCR0.75119988
82NEK20.73929553
83JAK30.73710683
84KDR0.73412512
85PINK10.72745344
86MINK10.71465366
87CDK80.71160829
88STK390.70627335
89PRKCG0.68966895
90CDC70.68704515
91MAP3K100.68534851
92PAK40.68514691
93MARK10.67946608
94MKNK10.67505269
95FGFR40.67137710
96ERBB30.65938800
97CAMK1D0.64273349
98DAPK10.64125503
99EPHA40.62446662
100DYRK30.60553248
101FER0.59389194
102ATR0.57912973
103PAK30.57609982
104CSNK1A1L0.54721539
105PRKACB0.52524486
106EIF2AK20.52145197
107MELK0.51976002
108CSNK1G30.51253824
109KSR10.51196378
110CAMK2A0.51095259
111IGF1R0.50055346
112STK110.49947944
113ATM0.49933976
114MAP3K80.48864413
115ADRBK10.48387652
116FES0.48270850
117YES10.48075405
118EGFR0.47620948
119MAP2K60.46709644
120AURKB0.46653176
121BRD40.46579549
122NUAK10.46368248
123NTRK20.45517623
124SGK20.45141773
125GRK50.45059816
126CDK40.44913450
127TAOK30.44588000
128GRK10.44457333
129MAPK40.43597226
130CHEK20.43197728
131PRKACA0.41571338
132PRKCB0.41447264
133JAK20.39679960
134CDK60.39244872
135RPS6KB20.38904389
136PRKG20.38483655
137STK40.37670449
138TRPM70.36802645
139EIF2AK30.36516437
140CAMK2B0.35312535
141PLK10.35130527
142PRKCQ0.34743425
143PHKG20.34346797
144PHKG10.34346797
145AURKA0.34228399
146MAP3K50.33662844
147CDK30.33539413
148TESK10.32390118
149CSNK1A10.32187626
150IKBKE0.31232197
151DYRK1A0.31044495
152IKBKB0.30792884
153MAP2K40.28729802
154PRKCH0.28681172
155CLK10.26990772
156HIPK20.25466487
157CDK70.25462348
158ROCK20.24467727
159MKNK20.24374853
160MAPK70.23712153
161NME20.23332448
162MAPK110.23296795
163ERBB40.22680538
164PIK3CA0.22573815

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046143.39947770
2DNA replication_Homo sapiens_hsa030303.19789872
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.06196997
4Nicotine addiction_Homo sapiens_hsa050332.81801922
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74487436
6Proteasome_Homo sapiens_hsa030502.50959778
7Primary immunodeficiency_Homo sapiens_hsa053402.43520592
8Phototransduction_Homo sapiens_hsa047442.40079762
9Mismatch repair_Homo sapiens_hsa034302.33479686
10Protein export_Homo sapiens_hsa030602.29284865
11Fatty acid elongation_Homo sapiens_hsa000622.25323192
12Base excision repair_Homo sapiens_hsa034102.24848572
13Taste transduction_Homo sapiens_hsa047422.19247131
14Folate biosynthesis_Homo sapiens_hsa007902.16065401
15Non-homologous end-joining_Homo sapiens_hsa034502.04157085
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.01084274
17Sulfur metabolism_Homo sapiens_hsa009201.98988975
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94903992
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.88501330
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85118920
21Ribosome_Homo sapiens_hsa030101.82038869
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74848425
23Propanoate metabolism_Homo sapiens_hsa006401.73955715
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.73642553
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70894009
26Pyrimidine metabolism_Homo sapiens_hsa002401.63186429
27Starch and sucrose metabolism_Homo sapiens_hsa005001.61053335
28Amphetamine addiction_Homo sapiens_hsa050311.60554153
29Pyruvate metabolism_Homo sapiens_hsa006201.60017696
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58391650
31GABAergic synapse_Homo sapiens_hsa047271.55696729
32Carbon metabolism_Homo sapiens_hsa012001.48805723
33Steroid biosynthesis_Homo sapiens_hsa001001.48264540
34Fanconi anemia pathway_Homo sapiens_hsa034601.47969463
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.47273012
36Spliceosome_Homo sapiens_hsa030401.45164545
37Peroxisome_Homo sapiens_hsa041461.41591468
38Butanoate metabolism_Homo sapiens_hsa006501.41578219
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41322596
40Caffeine metabolism_Homo sapiens_hsa002321.41290802
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38189068
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.37490109
43Nucleotide excision repair_Homo sapiens_hsa034201.36295427
44Cell cycle_Homo sapiens_hsa041101.32745998
45Biosynthesis of amino acids_Homo sapiens_hsa012301.27291799
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26851816
47Chemical carcinogenesis_Homo sapiens_hsa052041.26643124
48Cocaine addiction_Homo sapiens_hsa050301.25849962
49Fatty acid degradation_Homo sapiens_hsa000711.25320822
50RNA polymerase_Homo sapiens_hsa030201.25316641
51Pentose phosphate pathway_Homo sapiens_hsa000301.24708061
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.23301718
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22784359
54Circadian rhythm_Homo sapiens_hsa047101.20283449
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.18135880
56Homologous recombination_Homo sapiens_hsa034401.17526629
57Dopaminergic synapse_Homo sapiens_hsa047281.17129862
58Selenocompound metabolism_Homo sapiens_hsa004501.15570964
59Systemic lupus erythematosus_Homo sapiens_hsa053221.15436116
60One carbon pool by folate_Homo sapiens_hsa006701.15178242
61Morphine addiction_Homo sapiens_hsa050321.14201128
62Tryptophan metabolism_Homo sapiens_hsa003801.13597370
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12281109
64Glutamatergic synapse_Homo sapiens_hsa047241.12065684
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11370134
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07590615
67Circadian entrainment_Homo sapiens_hsa047131.07409460
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05330223
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02529325
70Drug metabolism - other enzymes_Homo sapiens_hsa009831.01227406
71Vitamin B6 metabolism_Homo sapiens_hsa007501.00706291
72RNA transport_Homo sapiens_hsa030130.99512027
73RNA degradation_Homo sapiens_hsa030180.99117485
74Renin secretion_Homo sapiens_hsa049240.98274959
75Antigen processing and presentation_Homo sapiens_hsa046120.97453027
76Oocyte meiosis_Homo sapiens_hsa041140.95260540
77Fatty acid metabolism_Homo sapiens_hsa012120.92059677
78Oxidative phosphorylation_Homo sapiens_hsa001900.91545629
79Parkinsons disease_Homo sapiens_hsa050120.90944128
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90875594
81Calcium signaling pathway_Homo sapiens_hsa040200.89653579
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88125827
83T cell receptor signaling pathway_Homo sapiens_hsa046600.85624346
84Histidine metabolism_Homo sapiens_hsa003400.85474016
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.85022365
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83905394
87Linoleic acid metabolism_Homo sapiens_hsa005910.80541218
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78689873
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76202070
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76002278
91B cell receptor signaling pathway_Homo sapiens_hsa046620.75407616
92Serotonergic synapse_Homo sapiens_hsa047260.75318995
93Basal transcription factors_Homo sapiens_hsa030220.74683776
94Herpes simplex infection_Homo sapiens_hsa051680.73969433
95Vibrio cholerae infection_Homo sapiens_hsa051100.72364957
96Purine metabolism_Homo sapiens_hsa002300.71637393
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71342164
98Insulin secretion_Homo sapiens_hsa049110.69754615
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69376965
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69100633
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67509738
102Allograft rejection_Homo sapiens_hsa053300.64849643
103Alcoholism_Homo sapiens_hsa050340.64306330
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64069724
105Metabolic pathways_Homo sapiens_hsa011000.60366762
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60035692
107Epstein-Barr virus infection_Homo sapiens_hsa051690.57993072
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57669801
109Galactose metabolism_Homo sapiens_hsa000520.57278869
110Regulation of autophagy_Homo sapiens_hsa041400.56810250
111Long-term potentiation_Homo sapiens_hsa047200.56596068
112Gastric acid secretion_Homo sapiens_hsa049710.52968691
113Mineral absorption_Homo sapiens_hsa049780.52899549
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52668960
115mRNA surveillance pathway_Homo sapiens_hsa030150.52503385
116Glutathione metabolism_Homo sapiens_hsa004800.51986315
117Salivary secretion_Homo sapiens_hsa049700.51533261
118Olfactory transduction_Homo sapiens_hsa047400.51525270
119Hematopoietic cell lineage_Homo sapiens_hsa046400.51469293
120Ether lipid metabolism_Homo sapiens_hsa005650.49584900
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49373973
122N-Glycan biosynthesis_Homo sapiens_hsa005100.49178413
123Fructose and mannose metabolism_Homo sapiens_hsa000510.48789943
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45664525
125Measles_Homo sapiens_hsa051620.45272331
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44784605
127Glucagon signaling pathway_Homo sapiens_hsa049220.42199792
128Shigellosis_Homo sapiens_hsa051310.41374657
129Legionellosis_Homo sapiens_hsa051340.41180277
130cAMP signaling pathway_Homo sapiens_hsa040240.41034725
131Phenylalanine metabolism_Homo sapiens_hsa003600.39333407
132Alzheimers disease_Homo sapiens_hsa050100.38798889
133Cholinergic synapse_Homo sapiens_hsa047250.37872472
134Arginine and proline metabolism_Homo sapiens_hsa003300.37513302
135Collecting duct acid secretion_Homo sapiens_hsa049660.36832438
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36217374
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35983451
138Nitrogen metabolism_Homo sapiens_hsa009100.35941069
139Fatty acid biosynthesis_Homo sapiens_hsa000610.35720418
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.35557970
141Viral carcinogenesis_Homo sapiens_hsa052030.34481796
142Retinol metabolism_Homo sapiens_hsa008300.33832194
143Sulfur relay system_Homo sapiens_hsa041220.33822806
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33547676
145Gap junction_Homo sapiens_hsa045400.33259730
146beta-Alanine metabolism_Homo sapiens_hsa004100.32738114
147Vitamin digestion and absorption_Homo sapiens_hsa049770.31225713
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30434085
149Arginine biosynthesis_Homo sapiens_hsa002200.30147310
150Long-term depression_Homo sapiens_hsa047300.29650375
151Synaptic vesicle cycle_Homo sapiens_hsa047210.29120928
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28356189
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26767596

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