AP5S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.87071850
2L-phenylalanine catabolic process (GO:0006559)4.87071850
3aldehyde catabolic process (GO:0046185)4.65254277
4L-phenylalanine metabolic process (GO:0006558)4.62395328
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.62395328
6DNA deamination (GO:0045006)4.61788912
7behavioral response to nicotine (GO:0035095)4.45588674
8respiratory chain complex IV assembly (GO:0008535)4.40635894
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.09350927
10water-soluble vitamin biosynthetic process (GO:0042364)4.06132625
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.03881353
12cytochrome complex assembly (GO:0017004)4.03613739
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.02342681
14mitochondrial respiratory chain complex assembly (GO:0033108)4.00861932
15ATP synthesis coupled proton transport (GO:0015986)3.91635665
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.91635665
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.88308445
18glyoxylate metabolic process (GO:0046487)3.88032414
19indolalkylamine metabolic process (GO:0006586)3.85114561
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83947447
21platelet dense granule organization (GO:0060155)3.81002623
22aromatic amino acid family catabolic process (GO:0009074)3.79075692
23uronic acid metabolic process (GO:0006063)3.77085687
24glucuronate metabolic process (GO:0019585)3.77085687
25piRNA metabolic process (GO:0034587)3.76298029
26fucose catabolic process (GO:0019317)3.70965262
27L-fucose metabolic process (GO:0042354)3.70965262
28L-fucose catabolic process (GO:0042355)3.70965262
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.64803375
30respiratory electron transport chain (GO:0022904)3.62519995
31response to pheromone (GO:0019236)3.60601794
32tricarboxylic acid cycle (GO:0006099)3.57530827
33cellular glucuronidation (GO:0052695)3.54581700
34electron transport chain (GO:0022900)3.52240474
35alpha-linolenic acid metabolic process (GO:0036109)3.50049783
36regulation of cholesterol esterification (GO:0010872)3.45651527
37NADH metabolic process (GO:0006734)3.43522610
38detection of light stimulus involved in sensory perception (GO:0050962)3.41038471
39detection of light stimulus involved in visual perception (GO:0050908)3.41038471
40bile acid biosynthetic process (GO:0006699)3.40052259
41high-density lipoprotein particle remodeling (GO:0034375)3.32257510
42fatty acid catabolic process (GO:0009062)3.31806107
43preassembly of GPI anchor in ER membrane (GO:0016254)3.27942029
44monocarboxylic acid catabolic process (GO:0072329)3.24315285
45axoneme assembly (GO:0035082)3.18124508
46peptidyl-glutamic acid carboxylation (GO:0017187)3.17969908
47protein carboxylation (GO:0018214)3.17969908
48protein K6-linked ubiquitination (GO:0085020)3.15468247
49coenzyme catabolic process (GO:0009109)3.15219607
50phenylpropanoid metabolic process (GO:0009698)3.14661245
51negative regulation of telomere maintenance (GO:0032205)3.14334440
52kynurenine metabolic process (GO:0070189)3.11943591
53fat-soluble vitamin biosynthetic process (GO:0042362)3.10899026
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09006823
55response to nitrosative stress (GO:0051409)3.08958319
56cysteine metabolic process (GO:0006534)3.08183754
572-oxoglutarate metabolic process (GO:0006103)3.08133226
58protein-cofactor linkage (GO:0018065)3.08043515
59fatty acid beta-oxidation (GO:0006635)3.07875251
60xenobiotic catabolic process (GO:0042178)3.06370896
61glycerophospholipid catabolic process (GO:0046475)3.05810367
62tryptophan catabolic process (GO:0006569)3.04466392
63indole-containing compound catabolic process (GO:0042436)3.04466392
64indolalkylamine catabolic process (GO:0046218)3.04466392
65negative regulation of fibrinolysis (GO:0051918)3.03824594
66lysine catabolic process (GO:0006554)3.03562369
67lysine metabolic process (GO:0006553)3.03562369
68cellular ketone body metabolic process (GO:0046950)3.02082247
69cofactor catabolic process (GO:0051187)3.01560926
70regulation of fibrinolysis (GO:0051917)3.00247912
71replication fork processing (GO:0031297)2.98625476
72ubiquinone biosynthetic process (GO:0006744)2.98021170
73oxaloacetate metabolic process (GO:0006107)2.97551194
74branched-chain amino acid catabolic process (GO:0009083)2.97051142
75succinate metabolic process (GO:0006105)2.93175251
76flavonoid metabolic process (GO:0009812)2.91381908
77cellular response to ATP (GO:0071318)2.91083044
78artery smooth muscle contraction (GO:0014824)2.91001632
79DNA methylation involved in gamete generation (GO:0043046)2.89906960
80adenosine metabolic process (GO:0046085)2.88378746
81short-chain fatty acid metabolic process (GO:0046459)2.86955757
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85489454
83regulation of hexokinase activity (GO:1903299)2.85399604
84regulation of glucokinase activity (GO:0033131)2.85399604
85phospholipid efflux (GO:0033700)2.85312255
86signal peptide processing (GO:0006465)2.84263301
87aromatic amino acid family metabolic process (GO:0009072)2.83680914
88peroxisome fission (GO:0016559)2.83106388
89fatty acid oxidation (GO:0019395)2.82006870
90reverse cholesterol transport (GO:0043691)2.81140883
91benzene-containing compound metabolic process (GO:0042537)2.81074460
92C-terminal protein lipidation (GO:0006501)2.80765457
93plasma lipoprotein particle remodeling (GO:0034369)2.80455760
94protein-lipid complex remodeling (GO:0034368)2.80455760
95macromolecular complex remodeling (GO:0034367)2.80455760
96lipid oxidation (GO:0034440)2.80313508
97tryptophan metabolic process (GO:0006568)2.79631626
98pseudouridine synthesis (GO:0001522)2.78256249
99arginine metabolic process (GO:0006525)2.76117412
100regulation of cilium movement (GO:0003352)2.75795562
101sulfur amino acid catabolic process (GO:0000098)2.75428730
102cholesterol efflux (GO:0033344)2.75126746
103acetyl-CoA metabolic process (GO:0006084)2.75074080
104very long-chain fatty acid metabolic process (GO:0000038)2.74832496
105GPI anchor metabolic process (GO:0006505)2.74763404
106indole-containing compound metabolic process (GO:0042430)2.73680432
107protein K11-linked deubiquitination (GO:0035871)2.73645295
108regulation of triglyceride catabolic process (GO:0010896)2.73575035
109* double-strand break repair via homologous recombination (GO:0000724)2.73167193
110* recombinational repair (GO:0000725)2.72915817
111protein neddylation (GO:0045116)2.72910512
112carboxylic acid catabolic process (GO:0046395)2.72481199
113organic acid catabolic process (GO:0016054)2.72481199
114aspartate family amino acid catabolic process (GO:0009068)2.70710488
115ATP biosynthetic process (GO:0006754)2.70443247
116dopamine transport (GO:0015872)2.69365561
117cornea development in camera-type eye (GO:0061303)2.68268109
118reflex (GO:0060004)2.68075093
119regulation of hippo signaling (GO:0035330)2.67708292
120oxidative phosphorylation (GO:0006119)2.66194991
121tyrosine metabolic process (GO:0006570)2.65145021
122positive regulation of defense response to virus by host (GO:0002230)2.64494411
123ubiquinone metabolic process (GO:0006743)2.64375076
124cytidine deamination (GO:0009972)2.62887869
125cytidine metabolic process (GO:0046087)2.62887869
126cytidine catabolic process (GO:0006216)2.62887869
127C-terminal protein amino acid modification (GO:0018410)2.62696654
128amine catabolic process (GO:0009310)2.62538885
129cellular biogenic amine catabolic process (GO:0042402)2.62538885
130auditory receptor cell stereocilium organization (GO:0060088)2.62424002
131epithelial cilium movement (GO:0003351)2.61873638
132alpha-amino acid catabolic process (GO:1901606)2.60837268
133nucleotide transmembrane transport (GO:1901679)2.60300854
134bile acid metabolic process (GO:0008206)2.59923527
135complement activation, alternative pathway (GO:0006957)2.59198757
136polyol catabolic process (GO:0046174)2.58119430
137regulation of protein activation cascade (GO:2000257)2.58041014
138amino-acid betaine metabolic process (GO:0006577)2.57741275
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.57138762
140cellular amino acid catabolic process (GO:0009063)2.57088780
141photoreceptor cell maintenance (GO:0045494)2.56604495
142ketone body metabolic process (GO:1902224)2.56594407
143protein complex biogenesis (GO:0070271)2.55935087
144detection of mechanical stimulus involved in sensory perception (GO:0050974)2.55488927
145amino acid salvage (GO:0043102)2.55071507
146L-methionine salvage (GO:0071267)2.55071507
147L-methionine biosynthetic process (GO:0071265)2.55071507
148negative regulation of mast cell activation (GO:0033004)2.54868072
149regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54614459
150mannosylation (GO:0097502)2.54356052
151inositol phosphate catabolic process (GO:0071545)2.54281317
152plasma lipoprotein particle clearance (GO:0034381)2.53770836
153DNA double-strand break processing (GO:0000729)2.51320154
154NAD metabolic process (GO:0019674)2.51186112
155adaptation of signaling pathway (GO:0023058)2.50170745
156dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.49143189
157branched-chain amino acid metabolic process (GO:0009081)2.48945921
158tonic smooth muscle contraction (GO:0014820)2.48471222
159urea metabolic process (GO:0019627)2.48422303
160urea cycle (GO:0000050)2.48422303
161inner mitochondrial membrane organization (GO:0007007)2.47892989
162peptidyl-histidine modification (GO:0018202)2.47606989
163neuronal action potential (GO:0019228)2.47292194
164thioester metabolic process (GO:0035383)2.47083763
165acyl-CoA metabolic process (GO:0006637)2.47083763
166G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47056932
167anterograde synaptic vesicle transport (GO:0048490)2.46301468
168sulfation (GO:0051923)2.46154305
169alkaloid metabolic process (GO:0009820)2.45453467
170synaptic transmission, cholinergic (GO:0007271)2.45379174
171primary alcohol catabolic process (GO:0034310)2.44642361
172protein polyglutamylation (GO:0018095)2.44480393
173ethanol oxidation (GO:0006069)2.44241404
174NADH dehydrogenase complex assembly (GO:0010257)2.44234483
175mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44234483
176arginine catabolic process (GO:0006527)2.44101307
177tRNA processing (GO:0008033)2.43304472
178negative regulation of calcium ion transport into cytosol (GO:0010523)2.42878796
179cilium morphogenesis (GO:0060271)2.42856676
180rRNA modification (GO:0000154)2.39366336
181meiotic chromosome segregation (GO:0045132)2.37688366
182reciprocal DNA recombination (GO:0035825)2.36390396
183reciprocal meiotic recombination (GO:0007131)2.36390396
184endosome to melanosome transport (GO:0035646)2.34860141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.52660287
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.66826775
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.13847276
4ZNF274_21170338_ChIP-Seq_K562_Hela3.92874468
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.81710615
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55306991
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.49911974
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.36878242
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.30189979
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.01634868
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.76116837
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62222567
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.62130409
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52928760
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49439397
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46795752
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34926519
18IGF1R_20145208_ChIP-Seq_DFB_Human2.25258225
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18903218
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11974635
21EWS_26573619_Chip-Seq_HEK293_Human2.10748631
22* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.08597745
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02854093
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.02348734
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.00646560
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.98593481
27ER_23166858_ChIP-Seq_MCF-7_Human1.95726079
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.92328637
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.88463020
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87676702
31GBX2_23144817_ChIP-Seq_PC3_Human1.82743337
32TP53_22573176_ChIP-Seq_HFKS_Human1.80422564
33TAF15_26573619_Chip-Seq_HEK293_Human1.80160914
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79573647
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78812281
36P300_19829295_ChIP-Seq_ESCs_Human1.77849742
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75161671
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73064834
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71099665
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69532133
41BCAT_22108803_ChIP-Seq_LS180_Human1.61702154
42FUS_26573619_Chip-Seq_HEK293_Human1.60998278
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57660347
44VDR_23849224_ChIP-Seq_CD4+_Human1.52046426
45IRF1_19129219_ChIP-ChIP_H3396_Human1.51225456
46ELK1_19687146_ChIP-ChIP_HELA_Human1.50753062
47CBP_20019798_ChIP-Seq_JUKART_Human1.49258627
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49258627
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49157120
50MYC_18940864_ChIP-ChIP_HL60_Human1.48783473
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47451794
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47140822
53HTT_18923047_ChIP-ChIP_STHdh_Human1.46331946
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45599267
55GATA1_22025678_ChIP-Seq_K562_Human1.44647219
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43736664
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42709345
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.42060551
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42060551
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41525294
61STAT3_23295773_ChIP-Seq_U87_Human1.40884444
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.38654604
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.38042170
64SOX2_19829295_ChIP-Seq_ESCs_Human1.36821690
65NANOG_19829295_ChIP-Seq_ESCs_Human1.36821690
66AR_25329375_ChIP-Seq_VCAP_Human1.36233682
67AR_20517297_ChIP-Seq_VCAP_Human1.35082637
68SMAD4_21799915_ChIP-Seq_A2780_Human1.32923406
69TCF4_23295773_ChIP-Seq_U87_Human1.32200085
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31787666
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30867097
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30048975
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29398732
74EZH2_22144423_ChIP-Seq_EOC_Human1.27759298
75NCOR_22424771_ChIP-Seq_293T_Human1.27471398
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27347738
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26680725
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26561966
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26191140
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26100482
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25584974
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.24360918
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23824397
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.22823913
85TCF4_22108803_ChIP-Seq_LS180_Human1.22484828
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.22057012
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.21770656
88HOXB7_26014856_ChIP-Seq_BT474_Human1.21301276
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.20697086
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.19046574
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18296476
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17329000
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16704709
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16551418
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15561173
96CDX2_22108803_ChIP-Seq_LS180_Human1.15057457
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14960971
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11644246
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.10029243
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.09695968
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07903560
102FOXP3_21729870_ChIP-Seq_TREG_Human1.06305145
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.05812167
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.05616551
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05181838
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04975180
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04365246
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03775031
109ERG_20517297_ChIP-Seq_VCAP_Human1.02932376
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02003559
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01626097
112ERA_21632823_ChIP-Seq_H3396_Human1.01578750
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00896843
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00838675
115AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00688957
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.99901863
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99877393
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98473609
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98200626
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98016953
121RUNX2_22187159_ChIP-Seq_PCA_Human0.97387243
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97295305
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97066538
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96841909
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96454485
126GATA3_26560356_Chip-Seq_TH2_Human0.96432734
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96376364
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95815967
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.95530743
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94968103
131REST_18959480_ChIP-ChIP_MESCs_Mouse0.94662967
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94526490
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94151325
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94136335
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93605100
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.92345856
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89935802
138TAF2_19829295_ChIP-Seq_ESCs_Human0.89293349
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87396739
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.86328590
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.84541116
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84164863
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83128257
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82905682
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81904853
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81904853
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81848565
148NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81820385
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81387914
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81255021
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78941753
152EZH2_27294783_Chip-Seq_ESCs_Mouse0.77873664
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77011609
154CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76463437
155Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76452190
156PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73858569
157LXR_22292898_ChIP-Seq_THP-1_Human0.73374441
158MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72512378
159EZH2_18974828_ChIP-Seq_MESCs_Mouse0.72293950
160RNF2_18974828_ChIP-Seq_MESCs_Mouse0.72293950
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.72006053
162EP300_21415370_ChIP-Seq_HL-1_Mouse0.71848918
163SA1_27219007_Chip-Seq_Bcells_Human0.71462709
164JARID2_20075857_ChIP-Seq_MESCs_Mouse0.71378060
165VDR_22108803_ChIP-Seq_LS180_Human0.70739429
166CTCF_27219007_Chip-Seq_Bcells_Human0.70723464
167GABP_17652178_ChIP-ChIP_JURKAT_Human0.68858132
168ZFP57_27257070_Chip-Seq_ESCs_Mouse0.68613320
169REST_21632747_ChIP-Seq_MESCs_Mouse0.68127571
170IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.67548198
171LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.67027904
172BCL6_27268052_Chip-Seq_Bcells_Human0.66734807
173GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64139786
174JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.64006207
175CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.63978104
176CTCF_18555785_ChIP-Seq_MESCs_Mouse0.63259472
177DROSHA_22980978_ChIP-Seq_HELA_Human0.63162338
178IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.61892203
179BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61581445
180BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61575063
181NANOG_20526341_ChIP-Seq_ESCs_Human0.60846044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.07153679
2MP0005360_urolithiasis4.24596814
3MP0002837_dystrophic_cardiac_calcinosis3.97491927
4MP0008875_abnormal_xenobiotic_pharmacok3.86951888
5MP0005085_abnormal_gallbladder_physiolo3.62113636
6MP0003806_abnormal_nucleotide_metabolis3.52749954
7MP0002102_abnormal_ear_morphology3.42017089
8MP0005365_abnormal_bile_salt3.36607419
9MP0009840_abnormal_foam_cell2.73172065
10MP0003191_abnormal_cellular_cholesterol2.56014476
11MP0005551_abnormal_eye_electrophysiolog2.51045403
12MP0010329_abnormal_lipoprotein_level2.48601948
13MP0002822_catalepsy2.41620268
14MP0008877_abnormal_DNA_methylation2.36436829
15MP0003724_increased_susceptibility_to2.09054791
16MP0005332_abnormal_amino_acid2.07594567
17MP0002938_white_spotting2.00658272
18MP0005174_abnormal_tail_pigmentation1.99922200
19MP0001666_abnormal_nutrient_absorption1.98685616
20MP0005083_abnormal_biliary_tract1.96718179
21MP0003195_calcinosis1.92465845
22MP0005075_abnormal_melanosome_morpholog1.90307262
23MP0002638_abnormal_pupillary_reflex1.88373281
24MP0006036_abnormal_mitochondrial_physio1.87935244
25MP0002138_abnormal_hepatobiliary_system1.84646404
26MP0000569_abnormal_digit_pigmentation1.84536460
27MP0003329_amyloid_beta_deposits1.84347308
28MP0003880_abnormal_central_pattern1.81843286
29MP0003656_abnormal_erythrocyte_physiolo1.74796619
30MP0001764_abnormal_homeostasis1.72827929
31MP0005253_abnormal_eye_physiology1.67220701
32MP0001986_abnormal_taste_sensitivity1.66037644
33MP0002118_abnormal_lipid_homeostasis1.61611689
34MP0003252_abnormal_bile_duct1.60147808
35MP0009046_muscle_twitch1.59612924
36MP0009780_abnormal_chondrocyte_physiolo1.59094590
37MP0000015_abnormal_ear_pigmentation1.57826271
38MP0001529_abnormal_vocalization1.54334671
39MP0005389_reproductive_system_phenotype1.53683865
40MP0002160_abnormal_reproductive_system1.52367292
41MP0000749_muscle_degeneration1.51883416
42MP0000604_amyloidosis1.50892781
43MP0006072_abnormal_retinal_apoptosis1.50609294
44MP0005319_abnormal_enzyme/_coenzyme1.50065279
45MP0005584_abnormal_enzyme/coenzyme_acti1.49848436
46MP0005171_absent_coat_pigmentation1.49193731
47MP0004130_abnormal_muscle_cell1.45481089
48MP0004043_abnormal_pH_regulation1.45414633
49MP0000427_abnormal_hair_cycle1.44953857
50MP0005058_abnormal_lysosome_morphology1.44741655
51MP0004084_abnormal_cardiac_muscle1.43407250
52MP0003436_decreased_susceptibility_to1.41973878
53MP0003718_maternal_effect1.39325413
54MP0003950_abnormal_plasma_membrane1.37956631
55MP0009379_abnormal_foot_pigmentation1.37823472
56MP0003690_abnormal_glial_cell1.37546565
57MP0000609_abnormal_liver_physiology1.37218100
58MP0001919_abnormal_reproductive_system1.36841145
59MP0004036_abnormal_muscle_relaxation1.33920839
60MP0002163_abnormal_gland_morphology1.29374051
61MP0000751_myopathy1.27658793
62MP0001984_abnormal_olfaction1.24831260
63MP0003136_yellow_coat_color1.24617366
64MP0003646_muscle_fatigue1.23913345
65MP0002234_abnormal_pharynx_morphology1.23783158
66MP0005670_abnormal_white_adipose1.21866923
67MP0004142_abnormal_muscle_tone1.20553560
68MP0004215_abnormal_myocardial_fiber1.19542255
69MP0003786_premature_aging1.18438836
70MP0002928_abnormal_bile_duct1.15332408
71MP0005535_abnormal_body_temperature1.15281850
72MP0003011_delayed_dark_adaptation1.14916941
73MP0001873_stomach_inflammation1.14569814
74MP0008058_abnormal_DNA_repair1.14296378
75MP0003186_abnormal_redox_activity1.13958488
76MP0005379_endocrine/exocrine_gland_phen1.13794892
77MP0004133_heterotaxia1.13432680
78MP0009643_abnormal_urine_homeostasis1.13251297
79MP0003787_abnormal_imprinting1.11239500
80MP0005410_abnormal_fertilization1.10932997
81MP0002693_abnormal_pancreas_physiology1.09752652
82MP0001485_abnormal_pinna_reflex1.09333978
83MP0005636_abnormal_mineral_homeostasis1.09066169
84MP0002736_abnormal_nociception_after1.08998239
85MP0002095_abnormal_skin_pigmentation1.08638358
86MP0004019_abnormal_vitamin_homeostasis1.08299078
87MP0006035_abnormal_mitochondrial_morpho1.06482087
88MP0002064_seizures1.05908774
89MP0002733_abnormal_thermal_nociception1.04875913
90MP0001905_abnormal_dopamine_level1.04664408
91MP0005084_abnormal_gallbladder_morpholo1.04570493
92MP0001970_abnormal_pain_threshold1.03298974
93MP0005645_abnormal_hypothalamus_physiol1.02212785
94MP0002909_abnormal_adrenal_gland1.01423630
95MP0000631_abnormal_neuroendocrine_gland0.99427377
96MP0004145_abnormal_muscle_electrophysio0.99134219
97MP0009785_altered_susceptibility_to0.99061291
98MP0008469_abnormal_protein_level0.98251906
99MP0008872_abnormal_physiological_respon0.98002502
100MP0005330_cardiomyopathy0.97728141
101MP0002078_abnormal_glucose_homeostasis0.97250912
102MP0002735_abnormal_chemical_nociception0.96072438
103MP0005646_abnormal_pituitary_gland0.93187964
104MP0000343_altered_response_to0.92180405
105MP0003075_altered_response_to0.91422448
106MP0006276_abnormal_autonomic_nervous0.90546949
107MP0009745_abnormal_behavioral_response0.90311640
108MP0001324_abnormal_eye_pigmentation0.89773535
109MP0009642_abnormal_blood_homeostasis0.89016443
110MP0008995_early_reproductive_senescence0.88913412
111MP0005376_homeostasis/metabolism_phenot0.88858357
112MP0001501_abnormal_sleep_pattern0.87846249
113MP0000230_abnormal_systemic_arterial0.87600166
114MP0001756_abnormal_urination0.87499204
115MP0000013_abnormal_adipose_tissue0.87368965
116MP0002272_abnormal_nervous_system0.86943491
117MP0000372_irregular_coat_pigmentation0.86496040
118MP0003045_fibrosis0.86493273
119MP0000371_diluted_coat_color0.86257496
120MP0004885_abnormal_endolymph0.85721939
121MP0000920_abnormal_myelination0.84883515
122MP0002653_abnormal_ependyma_morphology0.84555031
123MP0004510_myositis0.84250830
124MP0003283_abnormal_digestive_organ0.83886965
125MP0004147_increased_porphyrin_level0.83865244
126MP0001486_abnormal_startle_reflex0.83145608
127MP0002972_abnormal_cardiac_muscle0.82420885
128MP0004924_abnormal_behavior0.80814057
129MP0005386_behavior/neurological_phenoty0.80814057
130MP0002132_abnormal_respiratory_system0.79935973
131MP0005167_abnormal_blood-brain_barrier0.79218431
132MP0009764_decreased_sensitivity_to0.78842403
133MP0006082_CNS_inflammation0.78030069
134MP0000538_abnormal_urinary_bladder0.78029832
135MP0001929_abnormal_gametogenesis0.77464064
136MP0005377_hearing/vestibular/ear_phenot0.76447789
137MP0003878_abnormal_ear_physiology0.76447789
138MP0005165_increased_susceptibility_to0.76238219
139MP0001944_abnormal_pancreas_morphology0.75490021
140MP0003633_abnormal_nervous_system0.75266029
141MP0002876_abnormal_thyroid_physiology0.75167146
142MP0005395_other_phenotype0.74946041
143MP0002277_abnormal_respiratory_mucosa0.74302180
144MP0005195_abnormal_posterior_eye0.74180874
145MP0005000_abnormal_immune_tolerance0.73506246
146MP0009763_increased_sensitivity_to0.73418773
147MP0008775_abnormal_heart_ventricle0.73098270
148MP0008873_increased_physiological_sensi0.73025132
149MP0005448_abnormal_energy_balance0.72627949
150MP0002148_abnormal_hypersensitivity_rea0.72525144
151MP0003879_abnormal_hair_cell0.71883888
152MP0003635_abnormal_synaptic_transmissio0.71331720
153MP0001968_abnormal_touch/_nociception0.69845884
154MP0002295_abnormal_pulmonary_circulatio0.68453967
155MP0005025_abnormal_response_to0.67755904
156MP0004085_abnormal_heartbeat0.66978489
157MP0002572_abnormal_emotion/affect_behav0.65799901
158MP0009765_abnormal_xenobiotic_induced0.61893504
159MP0010386_abnormal_urinary_bladder0.61843106
160MP0005266_abnormal_metabolism0.61425430

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)4.31989012
2Pancreatic cysts (HP:0001737)4.31691296
3Abnormal mitochondria in muscle tissue (HP:0008316)4.17865052
4Acute necrotizing encephalopathy (HP:0006965)4.16700458
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.12648707
6Molar tooth sign on MRI (HP:0002419)4.03861161
7Abnormality of midbrain morphology (HP:0002418)4.03861161
8Acute encephalopathy (HP:0006846)3.84518440
9Hepatic necrosis (HP:0002605)3.70908848
10Pancreatic fibrosis (HP:0100732)3.63120047
11Hyperlipoproteinemia (HP:0010980)3.57919068
12Cerebral edema (HP:0002181)3.57631506
13Congenital stationary night blindness (HP:0007642)3.57182761
14Hepatocellular necrosis (HP:0001404)3.53869279
15Mitochondrial inheritance (HP:0001427)3.52522544
16True hermaphroditism (HP:0010459)3.43195189
17Abnormality of fatty-acid metabolism (HP:0004359)3.42136165
18Increased serum pyruvate (HP:0003542)3.41344506
19Abnormality of glycolysis (HP:0004366)3.41344506
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.34095481
21Progressive macrocephaly (HP:0004481)3.30112933
22Abnormality of the renal cortex (HP:0011035)3.29718796
23Deep venous thrombosis (HP:0002625)3.19564516
24Axonal loss (HP:0003447)3.19463531
25Nephronophthisis (HP:0000090)3.19163438
26Prolonged partial thromboplastin time (HP:0003645)3.18978395
27Increased CSF lactate (HP:0002490)3.11118663
28Palpitations (HP:0001962)3.08995079
29Attenuation of retinal blood vessels (HP:0007843)3.04095262
30Xanthomatosis (HP:0000991)2.90959823
31Renal Fanconi syndrome (HP:0001994)2.89940572
32Ketosis (HP:0001946)2.89672990
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88562672
34Abnormality of alanine metabolism (HP:0010916)2.88562672
35Hyperalaninemia (HP:0003348)2.88562672
36Hypobetalipoproteinemia (HP:0003563)2.86761112
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83795446
38Abnormality of the renal medulla (HP:0100957)2.82825058
39Abnormal gallbladder physiology (HP:0012438)2.76252365
40Cholecystitis (HP:0001082)2.76252365
41Increased intramyocellular lipid droplets (HP:0012240)2.73925750
42Lactic acidosis (HP:0003128)2.70517062
43Medial flaring of the eyebrow (HP:0010747)2.68021733
44Increased muscle lipid content (HP:0009058)2.66114509
45Hyperventilation (HP:0002883)2.66098942
46Chronic hepatic failure (HP:0100626)2.64009083
47Type II lissencephaly (HP:0007260)2.62453815
48Ketoacidosis (HP:0001993)2.59560701
49Pheochromocytoma (HP:0002666)2.59546182
50Neuroendocrine neoplasm (HP:0100634)2.59164064
51Renal cortical cysts (HP:0000803)2.57538911
52Gaze-evoked nystagmus (HP:0000640)2.55832402
53Congenital sensorineural hearing impairment (HP:0008527)2.54786281
54Increased IgM level (HP:0003496)2.54326683
55Hyperammonemia (HP:0001987)2.54167778
56Hypoglycemic coma (HP:0001325)2.52696764
57Intrahepatic cholestasis (HP:0001406)2.50448646
58Large for gestational age (HP:0001520)2.49096749
59Methylmalonic acidemia (HP:0002912)2.47794661
60Methylmalonic aciduria (HP:0012120)2.47550445
61Cystic liver disease (HP:0006706)2.47523848
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47332650
63Dicarboxylic aciduria (HP:0003215)2.47332650
64Complement deficiency (HP:0004431)2.45686953
65Metabolic acidosis (HP:0001942)2.45600980
66Polydipsia (HP:0001959)2.45282596
67Abnormal drinking behavior (HP:0030082)2.45282596
68Lethargy (HP:0001254)2.43409615
69Glycosuria (HP:0003076)2.42487000
70Abnormality of urine glucose concentration (HP:0011016)2.42487000
71Pendular nystagmus (HP:0012043)2.39797102
72Tubular atrophy (HP:0000092)2.39124582
73Abolished electroretinogram (ERG) (HP:0000550)2.38925762
74Fat malabsorption (HP:0002630)2.35257565
75Vomiting (HP:0002013)2.34841238
76Lipid accumulation in hepatocytes (HP:0006561)2.34222155
77Increased corneal curvature (HP:0100692)2.32313905
78Keratoconus (HP:0000563)2.32313905
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31801944
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31188160
81Abnormality of the common coagulation pathway (HP:0010990)2.30758883
82Sclerocornea (HP:0000647)2.30298802
83Hypolipoproteinemia (HP:0010981)2.29901520
84Joint hemorrhage (HP:0005261)2.28472337
85Exercise intolerance (HP:0003546)2.25582745
86Sudden death (HP:0001699)2.25530863
87Decreased central vision (HP:0007663)2.25513765
88Syncope (HP:0001279)2.25467498
89Congenital hepatic fibrosis (HP:0002612)2.25126735
90Hyperbilirubinemia (HP:0002904)2.24932779
91Optic disc pallor (HP:0000543)2.23805270
92Vacuolated lymphocytes (HP:0001922)2.23678572
93Systemic lupus erythematosus (HP:0002725)2.22757315
94Increased hepatocellular lipid droplets (HP:0006565)2.22741374
95Bundle branch block (HP:0011710)2.22721556
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22461493
97Neoplasm of head and neck (HP:0012288)2.22062471
98Esophageal neoplasm (HP:0100751)2.22062471
99Type I transferrin isoform profile (HP:0003642)2.19683437
100Abnormal gallbladder morphology (HP:0012437)2.19350818
101Cholelithiasis (HP:0001081)2.17248981
102Abnormal protein glycosylation (HP:0012346)2.15739146
103Abnormal glycosylation (HP:0012345)2.15739146
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15739146
105Abnormal protein N-linked glycosylation (HP:0012347)2.15739146
106Steatorrhea (HP:0002570)2.14340104
107Hyperglycinuria (HP:0003108)2.14314399
108Hypoalphalipoproteinemia (HP:0003233)2.11875262
109Respiratory failure (HP:0002878)2.11208466
110Furrowed tongue (HP:0000221)2.10727439
111Hyperglycinemia (HP:0002154)2.10718143
112Abnormality of purine metabolism (HP:0004352)2.10365652
113Exercise-induced myalgia (HP:0003738)2.10130726
114Asymmetric septal hypertrophy (HP:0001670)2.10025583
115Increased serum lactate (HP:0002151)2.09256123
116Abnormality of glycine metabolism (HP:0010895)2.08936410
117Abnormality of serine family amino acid metabolism (HP:0010894)2.08936410
118Albinism (HP:0001022)2.08406406
119Abnormal rod and cone electroretinograms (HP:0008323)2.08058577
120Aplasia/Hypoplasia of the tongue (HP:0010295)2.07949509
121Nausea (HP:0002018)2.06746835
122Abnormal biliary tract physiology (HP:0012439)2.06322912
123Bile duct proliferation (HP:0001408)2.06322912
124Focal motor seizures (HP:0011153)2.06138897
125Sensorimotor neuropathy (HP:0007141)2.06081797
126Late onset (HP:0003584)2.06021361
127Opisthotonus (HP:0002179)2.05746105
1283-Methylglutaconic aciduria (HP:0003535)2.05117358
129Progressive inability to walk (HP:0002505)2.04255206
130Hypothermia (HP:0002045)2.03976790
131Leukodystrophy (HP:0002415)2.03614317
132Myoglobinuria (HP:0002913)2.03231632
133Exercise-induced muscle cramps (HP:0003710)2.01688841
134Stomatitis (HP:0010280)2.00263764
135Inability to walk (HP:0002540)1.99949160
136Poor suck (HP:0002033)1.99923223
137Male pseudohermaphroditism (HP:0000037)1.98337853
138Prolonged QT interval (HP:0001657)1.97868882
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.97643069
140Polyuria (HP:0000103)1.96316692
141Severe muscular hypotonia (HP:0006829)1.96088974
142Progressive external ophthalmoplegia (HP:0000590)1.93594861
143Recurrent gram-negative bacterial infections (HP:0005420)1.92977704
144Abnormality of the gallbladder (HP:0005264)1.91989762
145Conjugated hyperbilirubinemia (HP:0002908)1.91890428
146Calf muscle hypertrophy (HP:0008981)1.91804509
147Proximal tubulopathy (HP:0000114)1.91269333
148Absent speech (HP:0001344)1.90490541
149Gout (HP:0001997)1.89965079
150Small hand (HP:0200055)1.89775047
151Congenital primary aphakia (HP:0007707)1.89009748
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.87916490
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87798904
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87798904
155Prostate neoplasm (HP:0100787)1.87712463
156Severe visual impairment (HP:0001141)1.87449600
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.87089219
158Hypoplasia of the fovea (HP:0007750)1.87089219
159Gait imbalance (HP:0002141)1.87000384
160Muscle hypertrophy of the lower extremities (HP:0008968)1.85483561
161Heart block (HP:0012722)1.85181321
162CNS demyelination (HP:0007305)1.84417143
163Abnormal albumin level (HP:0012116)1.82954101
164Hypoalbuminemia (HP:0003073)1.82954101
165Concave nail (HP:0001598)1.81113426
166Nephrogenic diabetes insipidus (HP:0009806)1.80623202
167Thyroid-stimulating hormone excess (HP:0002925)1.78743036
168Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78596287
169Abnormality of renal resorption (HP:0011038)1.77887703
170Anencephaly (HP:0002323)1.77822127
171Tongue fasciculations (HP:0001308)1.77631435
172Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77514164
173Abnormality of DNA repair (HP:0003254)1.76421178
174Progressive microcephaly (HP:0000253)1.70977953
175Neoplasm of the adrenal cortex (HP:0100641)1.69400343
176Hypoplasia of the pons (HP:0012110)1.69398478
177Abnormality of the pons (HP:0007361)1.69236622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.43003482
2MAP3K125.46735443
3BCKDK5.24440693
4DAPK23.72654127
5MYLK3.41366336
6NUAK13.38707630
7ACVR1B2.80889363
8MUSK2.71471686
9ZAK2.39552156
10GRK12.37319062
11TXK2.27985621
12TLK12.23590745
13MAP4K22.12916787
14MAP2K62.12170739
15CASK2.03917293
16STK161.98676781
17WNK31.93520701
18TRIM281.91014082
19OBSCN1.84347331
20MAPK131.84228627
21PDK21.82347945
22PINK11.78595689
23VRK21.77712424
24MAPKAPK31.68941570
25MAP3K111.68581348
26MAP2K71.54679020
27TBK11.54211835
28ARAF1.53853310
29GRK71.50676612
30TAOK31.46269642
31DAPK11.44326494
32MAP2K41.42290466
33SRPK11.41847936
34SIK31.34477400
35BLK1.31694165
36MAPK121.31234849
37DAPK31.24939557
38ZAP701.24376243
39ERN11.23915424
40ADRBK11.21478844
41CAMKK21.17297383
42IKBKE1.14418910
43EIF2AK31.12819866
44MAP3K41.12485914
45CDK191.12351848
46STK241.06562077
47TYK21.04526549
48CSNK1G11.02998542
49BRSK21.02284833
50PHKG21.01556829
51PHKG11.01556829
52GRK61.00707705
53RIPK40.99054126
54PIK3CG0.98913640
55TAF10.98438956
56VRK10.96687772
57PLK20.95138581
58WNK40.94957558
59GRK50.94950219
60ERBB40.94764800
61TNIK0.92960240
62LMTK20.92817966
63MST40.92796740
64OXSR10.92761077
65CAMK2G0.83488299
66NME10.82220789
67CSNK1G20.79919670
68TTN0.77540542
69MAP4K10.77303536
70CAMK2D0.77111088
71CSNK1A1L0.75542550
72PRKCQ0.74262430
73EPHB20.70674660
74CAMK2A0.70628071
75MAPKAPK50.70500856
76SYK0.70432023
77TNK20.70204631
78EIF2AK10.68772373
79PDPK10.67884550
80NTRK30.67359432
81LIMK10.66977408
82INSRR0.66109400
83PIM20.65880211
84TIE10.65560442
85EPHA40.65520473
86FER0.64056488
87CDK80.63662518
88MAPK150.63322818
89TGFBR10.62975209
90TESK20.62174949
91PTK2B0.61273996
92NLK0.61181546
93FGFR40.60578870
94CCNB10.60375553
95PAK30.60023265
96TEC0.58816813
97CAMK2B0.58048696
98NEK90.57479243
99PRKCI0.57401150
100MAP2K30.57352992
101JAK20.56876038
102ABL20.54479864
103SIK10.54149882
104PRKCG0.53917657
105PRKCE0.53321393
106STK390.52631164
107MAPK110.52290765
108PKN10.51861808
109SIK20.51824411
110BCR0.51214944
111STK30.50434252
112DYRK20.50047620
113PRKACA0.49914180
114WEE10.49865330
115MST1R0.49013856
116ERBB30.48531335
117CSNK1G30.47510689
118PLK30.46414490
119ADRBK20.46197331
120PRKACG0.45362049
121STK38L0.45200302
122IKBKB0.44740440
123MAPK70.44465569
124KIT0.43431086
125PRKAA20.42429269
126JAK10.42321814
127PLK40.42196994
128PRKCD0.41296770
129PRKD10.40945999
130PRKD30.40699576
131PIK3CA0.40543759
132TESK10.40207027
133PRKAA10.40202834
134RPS6KA50.39827159
135FES0.39273254
136LYN0.39218623
137TRPM70.39041853
138MARK30.38981170
139AKT30.38104331
140SGK4940.37814393
141SGK2230.37814393
142MAP2K10.37656940
143PRKCA0.37547970
144CHEK20.35902254
145RPS6KA60.35716257
146BMPR20.35155151
147MAPK40.35068828
148ILK0.34993057
149EIF2AK20.34698200
150CSNK1D0.34676452
151NEK60.34568833
152BMPR1B0.34460269
153CHUK0.33947421
154IRAK10.33261322
155PLK10.30749913
156MELK0.30542169
157CAMK10.29969368
158CSNK1A10.29521924
159MATK0.28769565
160ABL10.28748851

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.03189281
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.81117302
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75769936
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.68880728
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.62230514
6Fatty acid degradation_Homo sapiens_hsa000712.46905359
7Homologous recombination_Homo sapiens_hsa034402.43516459
8Phototransduction_Homo sapiens_hsa047442.35587365
9Parkinsons disease_Homo sapiens_hsa050122.32506467
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.31216745
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24518564
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22293885
13Propanoate metabolism_Homo sapiens_hsa006402.20490315
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13595134
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13199110
16Fanconi anemia pathway_Homo sapiens_hsa034601.98351197
17RNA polymerase_Homo sapiens_hsa030201.97291559
18Pyruvate metabolism_Homo sapiens_hsa006201.95869083
19Collecting duct acid secretion_Homo sapiens_hsa049661.92187477
20Basal transcription factors_Homo sapiens_hsa030221.91305526
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87579022
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86081865
23Linoleic acid metabolism_Homo sapiens_hsa005911.85338787
24Peroxisome_Homo sapiens_hsa041461.84187045
25Butanoate metabolism_Homo sapiens_hsa006501.80820857
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79146164
27Sulfur metabolism_Homo sapiens_hsa009201.77929082
28Tryptophan metabolism_Homo sapiens_hsa003801.77166994
29Fatty acid metabolism_Homo sapiens_hsa012121.77041390
30Sulfur relay system_Homo sapiens_hsa041221.70628904
31Alzheimers disease_Homo sapiens_hsa050101.69914881
32Arginine biosynthesis_Homo sapiens_hsa002201.69461351
33Carbon metabolism_Homo sapiens_hsa012001.66514555
34Fatty acid elongation_Homo sapiens_hsa000621.65408660
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64129756
36Histidine metabolism_Homo sapiens_hsa003401.62792033
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62389628
38Chemical carcinogenesis_Homo sapiens_hsa052041.60945213
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58233032
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54133424
41Steroid biosynthesis_Homo sapiens_hsa001001.53557270
42Complement and coagulation cascades_Homo sapiens_hsa046101.48550031
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45443597
44Staphylococcus aureus infection_Homo sapiens_hsa051501.44973058
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43697851
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.43079891
47Folate biosynthesis_Homo sapiens_hsa007901.42071948
48Phenylalanine metabolism_Homo sapiens_hsa003601.40646152
49PPAR signaling pathway_Homo sapiens_hsa033201.36006082
50Cardiac muscle contraction_Homo sapiens_hsa042601.33374469
51Caffeine metabolism_Homo sapiens_hsa002321.32983736
52Huntingtons disease_Homo sapiens_hsa050161.21054756
53Biosynthesis of amino acids_Homo sapiens_hsa012301.19457972
54One carbon pool by folate_Homo sapiens_hsa006701.19128212
55Tyrosine metabolism_Homo sapiens_hsa003501.18147659
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17971995
57Starch and sucrose metabolism_Homo sapiens_hsa005001.16501346
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16160576
59Ether lipid metabolism_Homo sapiens_hsa005651.13239618
60Pyrimidine metabolism_Homo sapiens_hsa002401.11860216
61beta-Alanine metabolism_Homo sapiens_hsa004101.11643640
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04235896
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.01746216
64Synaptic vesicle cycle_Homo sapiens_hsa047210.97382090
65RNA degradation_Homo sapiens_hsa030180.96269933
66Vibrio cholerae infection_Homo sapiens_hsa051100.95246779
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95109595
68Pentose phosphate pathway_Homo sapiens_hsa000300.94676854
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.92879505
70Nucleotide excision repair_Homo sapiens_hsa034200.89494268
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88873481
72Purine metabolism_Homo sapiens_hsa002300.86016112
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.85642754
74Arachidonic acid metabolism_Homo sapiens_hsa005900.84390188
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83620626
76Retinol metabolism_Homo sapiens_hsa008300.83150417
77Fat digestion and absorption_Homo sapiens_hsa049750.80339306
78Non-homologous end-joining_Homo sapiens_hsa034500.79039655
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78934789
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.78014906
81Galactose metabolism_Homo sapiens_hsa000520.77862740
82Bile secretion_Homo sapiens_hsa049760.76229061
83Taste transduction_Homo sapiens_hsa047420.76215575
84Circadian rhythm_Homo sapiens_hsa047100.76114579
85Olfactory transduction_Homo sapiens_hsa047400.74470439
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74394315
87Glutathione metabolism_Homo sapiens_hsa004800.74167843
88Sphingolipid metabolism_Homo sapiens_hsa006000.72505501
89Metabolic pathways_Homo sapiens_hsa011000.72181947
90Vitamin B6 metabolism_Homo sapiens_hsa007500.71682176
91Rheumatoid arthritis_Homo sapiens_hsa053230.66358846
92Primary immunodeficiency_Homo sapiens_hsa053400.65631982
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64888000
94Ovarian steroidogenesis_Homo sapiens_hsa049130.64826936
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64600339
96Arginine and proline metabolism_Homo sapiens_hsa003300.64299588
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63728000
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63335819
99Morphine addiction_Homo sapiens_hsa050320.62579353
100ABC transporters_Homo sapiens_hsa020100.62086663
101Glycerolipid metabolism_Homo sapiens_hsa005610.61820924
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59525010
103N-Glycan biosynthesis_Homo sapiens_hsa005100.58258006
104Fructose and mannose metabolism_Homo sapiens_hsa000510.58182684
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56027474
106Serotonergic synapse_Homo sapiens_hsa047260.55282222
107Phagosome_Homo sapiens_hsa041450.52840963
108Selenocompound metabolism_Homo sapiens_hsa004500.49415760
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49127870
110Lysosome_Homo sapiens_hsa041420.48621545
111Calcium signaling pathway_Homo sapiens_hsa040200.46009983
112Mineral absorption_Homo sapiens_hsa049780.44728152
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41272195
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40805162
115Regulation of autophagy_Homo sapiens_hsa041400.36421642
116Protein export_Homo sapiens_hsa030600.33559032
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.32881068
118Dorso-ventral axis formation_Homo sapiens_hsa043200.32682573
119Circadian entrainment_Homo sapiens_hsa047130.32573324
120Mismatch repair_Homo sapiens_hsa034300.31892126
121Salivary secretion_Homo sapiens_hsa049700.31891561
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29405508
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29164391
124Vitamin digestion and absorption_Homo sapiens_hsa049770.28815181
125Nicotine addiction_Homo sapiens_hsa050330.28178575
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28166100
127p53 signaling pathway_Homo sapiens_hsa041150.27935125
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.27740154
129GABAergic synapse_Homo sapiens_hsa047270.25896875
130Other glycan degradation_Homo sapiens_hsa005110.25494137
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25249948
132Fatty acid biosynthesis_Homo sapiens_hsa000610.25042687
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23827215
134Nitrogen metabolism_Homo sapiens_hsa009100.21941419
135Graft-versus-host disease_Homo sapiens_hsa053320.20218956
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20047577
137Proteasome_Homo sapiens_hsa030500.19490933
138Insulin secretion_Homo sapiens_hsa049110.17100414
139Glucagon signaling pathway_Homo sapiens_hsa049220.13539991
140Dilated cardiomyopathy_Homo sapiens_hsa054140.09890411

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