AP5Z1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.03475064
2central nervous system myelination (GO:0022010)7.03475064
3neutrophil activation involved in immune response (GO:0002283)5.17845104
4long-chain fatty acid biosynthetic process (GO:0042759)4.73854298
5ensheathment of neurons (GO:0007272)4.53153253
6axon ensheathment (GO:0008366)4.53153253
7myelination (GO:0042552)4.46394789
8fatty acid elongation (GO:0030497)4.43046073
9response to peptidoglycan (GO:0032494)4.31066283
10negative regulation of erythrocyte differentiation (GO:0045647)4.22808797
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14730444
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.99802866
13antigen processing and presentation of endogenous antigen (GO:0019883)3.96911807
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.89698732
15positive regulation of antigen processing and presentation (GO:0002579)3.82670915
16L-amino acid import (GO:0043092)3.79888120
17response to lipoprotein particle (GO:0055094)3.78582492
18neutrophil activation (GO:0042119)3.75845201
19negative regulation of interleukin-12 production (GO:0032695)3.71884993
20NIK/NF-kappaB signaling (GO:0038061)3.64731638
21positive regulation of B cell differentiation (GO:0045579)3.64467376
22adhesion of symbiont to host cell (GO:0044650)3.64030246
23virion attachment to host cell (GO:0019062)3.64030246
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62571309
25regulation of antigen processing and presentation (GO:0002577)3.58659932
26amyloid precursor protein metabolic process (GO:0042982)3.58418349
27detection of other organism (GO:0098543)3.56163996
28detection of bacterium (GO:0016045)3.53518204
29positive regulation of gamma-delta T cell activation (GO:0046645)3.52096493
30granulocyte activation (GO:0036230)3.50575449
31respiratory burst (GO:0045730)3.48657965
32mannose metabolic process (GO:0006013)3.47825473
33oligodendrocyte differentiation (GO:0048709)3.47160061
34B cell receptor signaling pathway (GO:0050853)3.45311423
35germinal center formation (GO:0002467)3.41546035
36positive regulation of interleukin-17 production (GO:0032740)3.41221983
37modulation by symbiont of host immune response (GO:0052553)3.33514233
38positive regulation by symbiont of host defense response (GO:0052509)3.33514233
39modulation by symbiont of host defense response (GO:0052031)3.33514233
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33514233
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33514233
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.33514233
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31349867
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29272121
45regulation of interferon-beta biosynthetic process (GO:0045357)3.28460735
46amyloid precursor protein catabolic process (GO:0042987)3.26403270
47activated T cell proliferation (GO:0050798)3.24454087
48response to type I interferon (GO:0034340)3.20033279
49cellular response to type I interferon (GO:0071357)3.19493885
50type I interferon signaling pathway (GO:0060337)3.19493885
51negative regulation of neurotransmitter secretion (GO:0046929)3.18798140
52leukocyte migration involved in inflammatory response (GO:0002523)3.16867795
53positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.11269438
54interferon-gamma production (GO:0032609)3.11016787
55positive regulation of toll-like receptor signaling pathway (GO:0034123)3.08949600
56regulation of mast cell degranulation (GO:0043304)3.08097389
57regulation of gamma-delta T cell activation (GO:0046643)3.07442023
58detection of external biotic stimulus (GO:0098581)3.07414471
59creatine metabolic process (GO:0006600)3.06860337
60regulation of B cell receptor signaling pathway (GO:0050855)3.05590444
61Golgi to endosome transport (GO:0006895)3.05210289
62glycosylceramide metabolic process (GO:0006677)3.04371239
63myeloid cell activation involved in immune response (GO:0002275)3.04336324
64regulation of interleukin-17 production (GO:0032660)2.99393765
65negative regulation of macroautophagy (GO:0016242)2.97968312
66negative regulation of cytokine production involved in immune response (GO:0002719)2.97259681
67positive regulation of Cdc42 GTPase activity (GO:0043089)2.96238114
68regulation of leukocyte degranulation (GO:0043300)2.95927445
69regulation of type I interferon-mediated signaling pathway (GO:0060338)2.94898349
70leukocyte degranulation (GO:0043299)2.92373016
71adhesion of symbiont to host (GO:0044406)2.89636436
72regulation of B cell differentiation (GO:0045577)2.87245211
73protein localization to endosome (GO:0036010)2.85891897
74amino sugar catabolic process (GO:0046348)2.84203479
75protein kinase C signaling (GO:0070528)2.83405824
76positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.83131684
77amino acid import (GO:0043090)2.82989280
78detection of molecule of bacterial origin (GO:0032490)2.82748565
79import into cell (GO:0098657)2.80571529
80leukocyte aggregation (GO:0070486)2.80136878
81neutrophil mediated immunity (GO:0002446)2.80118644
82barbed-end actin filament capping (GO:0051016)2.79919038
83myeloid dendritic cell differentiation (GO:0043011)2.78912232
84regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77853214
85macrophage activation involved in immune response (GO:0002281)2.77150525
86regulation of mast cell activation involved in immune response (GO:0033006)2.76718993
87negative regulation of cell killing (GO:0031342)2.76297308
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76297308
89positive thymic T cell selection (GO:0045059)2.74783558
90regulation of T-helper 2 cell differentiation (GO:0045628)2.74356699
91response to host immune response (GO:0052572)2.72384619
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72384619
93regulation of neutrophil chemotaxis (GO:0090022)2.71168152
94regulation of neutrophil migration (GO:1902622)2.71168152
95response to protozoan (GO:0001562)2.70528409
96cellular extravasation (GO:0045123)2.70451648
97response to muramyl dipeptide (GO:0032495)2.70237077
98positive regulation of action potential (GO:0045760)2.69998495
99mature B cell differentiation involved in immune response (GO:0002313)2.68802095
100interferon-gamma-mediated signaling pathway (GO:0060333)2.68470684
101regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68096131
102detection of biotic stimulus (GO:0009595)2.67891950
103histone H3-K4 trimethylation (GO:0080182)2.67749179
104response to laminar fluid shear stress (GO:0034616)2.66957902
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66439310
106negative regulation of type 2 immune response (GO:0002829)2.65155468
107regulation of collateral sprouting (GO:0048670)2.64492527
108mast cell activation (GO:0045576)2.63287458
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62833218
110response to host (GO:0075136)2.62833218
111response to host defenses (GO:0052200)2.62833218
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62243318
113negative regulation of B cell proliferation (GO:0030889)2.61678838
114defense response to protozoan (GO:0042832)2.61479811
115negative regulation of innate immune response (GO:0045824)2.60520520
116negative regulation of interleukin-1 beta production (GO:0032691)2.60306048
117superoxide anion generation (GO:0042554)2.60076687
118mature B cell differentiation (GO:0002335)2.59783107
119negative regulation of leukocyte mediated immunity (GO:0002704)2.59400632
120positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.59247742
121regulation of gamma-delta T cell differentiation (GO:0045586)2.58776647
122regulation of type 2 immune response (GO:0002828)2.58523896
123heterotypic cell-cell adhesion (GO:0034113)2.57957558
124protein palmitoylation (GO:0018345)2.57520772
125B cell homeostasis (GO:0001782)2.57242051
126myeloid dendritic cell activation (GO:0001773)2.56786097
127macrophage activation (GO:0042116)2.56204032
128glycerophospholipid catabolic process (GO:0046475)2.53897706
129modulation by symbiont of host cellular process (GO:0044068)2.53666849
130pinocytosis (GO:0006907)2.51765930
131T cell migration (GO:0072678)2.51750036
132positive regulation of cellular amide metabolic process (GO:0034250)2.50844390
133glycosphingolipid catabolic process (GO:0046479)2.49646986
134T-helper 1 type immune response (GO:0042088)2.48816400
135intracellular pH reduction (GO:0051452)2.48726012
136positive regulation of interleukin-10 production (GO:0032733)2.48073985
137positive regulation of T cell cytokine production (GO:0002726)2.48073175
138positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.47606228
139immunoglobulin mediated immune response (GO:0016064)2.47563291
140positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.47394521
141negative regulation of myeloid cell apoptotic process (GO:0033033)2.47130294
142negative regulation of interleukin-6 production (GO:0032715)2.46737618
143regulation of necroptotic process (GO:0060544)2.45952841
144regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.45456019
145regulation of platelet aggregation (GO:0090330)2.44907862
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44861641
147thymic T cell selection (GO:0045061)2.44575538
148regulation of interleukin-12 biosynthetic process (GO:0045075)2.44177268
149regulation of activation of Janus kinase activity (GO:0010533)2.43113081
150regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.42934616
151negative regulation of lymphocyte mediated immunity (GO:0002707)2.42450629
152positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42062300
153regulation of necrotic cell death (GO:0010939)2.41699935
154regulation of interferon-alpha production (GO:0032647)2.41674881
155cellular response to virus (GO:0098586)2.39424494
156negative regulation of interleukin-1 production (GO:0032692)2.39043748
157positive regulation of interferon-alpha production (GO:0032727)2.38137983
158regulation of ARF GTPase activity (GO:0032312)2.37993063
159modulation by virus of host process (GO:0019054)2.37931139
160G-protein coupled receptor internalization (GO:0002031)2.37582631
161tolerance induction (GO:0002507)2.37488551
162preassembly of GPI anchor in ER membrane (GO:0016254)2.36949430
163cholesterol biosynthetic process (GO:0006695)2.36792618
164positive regulation of type 2 immune response (GO:0002830)2.36789946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human5.08313619
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.64446894
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.15154662
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.08346627
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50079495
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.45168900
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35363461
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96986249
9SCL_19346495_ChIP-Seq_HPC-7_Human2.76256673
10VDR_21846776_ChIP-Seq_THP-1_Human2.66724977
11MYC_22102868_ChIP-Seq_BL_Human2.60791144
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58751730
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.52941051
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52549576
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.32199873
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30531740
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18600696
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17848033
19SPI1_23127762_ChIP-Seq_K562_Human2.12831062
20VDR_24763502_ChIP-Seq_THP-1_Human2.08221080
21RUNX_20019798_ChIP-Seq_JUKART_Human2.06313513
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04126382
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02395913
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94962456
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93355223
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91735607
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88758330
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.88549816
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87500499
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85890651
31RACK7_27058665_Chip-Seq_MCF-7_Human1.81421991
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80894198
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79310429
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79074725
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77331216
36DROSHA_22980978_ChIP-Seq_HELA_Human1.74523280
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69886034
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68692174
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66907165
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65538021
41MAF_26560356_Chip-Seq_TH1_Human1.60529677
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60279812
43SPI1_23547873_ChIP-Seq_NB4_Human1.57694530
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.57319301
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.51655501
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49648204
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46226114
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45917072
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40826291
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40381633
51P68_20966046_ChIP-Seq_HELA_Human1.39991607
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39016129
53MYB_26560356_Chip-Seq_TH2_Human1.36992944
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.36423432
55VDR_24787735_ChIP-Seq_THP-1_Human1.36354277
56BCL6_27268052_Chip-Seq_Bcells_Human1.36353587
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35832279
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.33835064
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31931177
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31421661
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30376057
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27900922
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26994168
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.26660199
65PU_27001747_Chip-Seq_BMDM_Mouse1.25317315
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24740838
67NCOR1_26117541_ChIP-Seq_K562_Human1.23787710
68MYB_26560356_Chip-Seq_TH1_Human1.22775052
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22113655
70SMC4_20622854_ChIP-Seq_HELA_Human1.21715331
71GATA1_19941826_ChIP-Seq_K562_Human1.21509073
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21140864
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20376699
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18630660
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17468726
76GBX2_23144817_ChIP-Seq_PC3_Human1.17404013
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16565751
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16151695
79MAF_26560356_Chip-Seq_TH2_Human1.15469839
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15124768
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15075858
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14367236
83KDM2B_26808549_Chip-Seq_DND41_Human1.14321670
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14091445
85UTX_26944678_Chip-Seq_JUKART_Human1.12409577
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12368782
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12327738
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12181550
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11020692
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09811577
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09577459
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08569879
93GATA2_19941826_ChIP-Seq_K562_Human1.06641327
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.06244349
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05378961
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05297153
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04159522
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03933229
99TCF7_22412390_ChIP-Seq_EML_Mouse1.03154821
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02830375
101ZNF263_19887448_ChIP-Seq_K562_Human1.02579403
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01200214
103STAT1_20625510_ChIP-Seq_HELA_Human1.00931434
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99720209
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99606724
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98971812
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98872291
108PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98621741
109LXR_22292898_ChIP-Seq_THP-1_Human0.98609940
110CTCF_26484167_Chip-Seq_Bcells_Mouse0.98320957
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97972808
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94600360
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.93954598
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.90260067
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90220506
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90176333
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90152965
118BCOR_27268052_Chip-Seq_Bcells_Human0.86812028
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85871585
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82866038
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82504546
122GATA3_27048872_Chip-Seq_THYMUS_Human0.82175407
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81206357
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81173512
125SA1_27219007_Chip-Seq_Bcells_Human0.78754275
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75088203
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.74635810
128KDM2B_26808549_Chip-Seq_K562_Human0.72527987
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.72512132
130AHR_22903824_ChIP-Seq_MCF-7_Human0.72308246
131OCT4_20526341_ChIP-Seq_ESCs_Human0.70555013
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70517369
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.70377023
134GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70124948
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.69840226
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69613092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.74579522
2MP0003172_abnormal_lysosome_physiology3.48191347
3MP0005058_abnormal_lysosome_morphology3.36737717
4MP0001835_abnormal_antigen_presentation3.18981066
5MP0005387_immune_system_phenotype2.90846619
6MP0001790_abnormal_immune_system2.90846619
7MP0003690_abnormal_glial_cell2.57100592
8MP0005000_abnormal_immune_tolerance2.56989447
9MP0006082_CNS_inflammation2.52439460
10MP0002419_abnormal_innate_immunity2.52434778
11MP0008260_abnormal_autophagy2.49882606
12MP0000685_abnormal_immune_system2.48717068
13MP0005174_abnormal_tail_pigmentation2.47222176
14MP0001800_abnormal_humoral_immune2.41763104
15MP0005671_abnormal_response_to2.34426934
16MP0000569_abnormal_digit_pigmentation2.32959775
17MP0003436_decreased_susceptibility_to2.26174645
18MP0005451_abnormal_body_composition2.19507599
19MP0005025_abnormal_response_to2.19046336
20MP0002723_abnormal_immune_serum2.17688719
21MP0004381_abnormal_hair_follicle2.17196110
22MP0002452_abnormal_antigen_presenting2.14572841
23MP0003183_abnormal_peptide_metabolism2.01807902
24MP0009840_abnormal_foam_cell2.00412993
25MP0003136_yellow_coat_color1.99170397
26MP0005310_abnormal_salivary_gland1.98790295
27MP0002148_abnormal_hypersensitivity_rea1.98383886
28MP0003705_abnormal_hypodermis_morpholog1.96893301
29MP0005464_abnormal_platelet_physiology1.94953052
30MP0002420_abnormal_adaptive_immunity1.91300589
31MP0001819_abnormal_immune_cell1.89451482
32MP0005075_abnormal_melanosome_morpholog1.87029953
33MP0000015_abnormal_ear_pigmentation1.86308328
34MP0009785_altered_susceptibility_to1.80527075
35MP0004510_myositis1.71187178
36MP0001986_abnormal_taste_sensitivity1.66243845
37MP0000858_altered_metastatic_potential1.61757092
38MP0003191_abnormal_cellular_cholesterol1.61435060
39MP0003634_abnormal_glial_cell1.58180814
40MP0001545_abnormal_hematopoietic_system1.56806827
41MP0005397_hematopoietic_system_phenotyp1.56806827
42MP0003303_peritoneal_inflammation1.56386859
43MP0000716_abnormal_immune_system1.55271928
44MP0004742_abnormal_vestibular_system1.48880739
45MP0009333_abnormal_splenocyte_physiolog1.48376416
46MP0001873_stomach_inflammation1.45481559
47MP0009278_abnormal_bone_marrow1.40603084
48MP0002398_abnormal_bone_marrow1.40210545
49MP0005409_darkened_coat_color1.34350786
50MP0002405_respiratory_system_inflammati1.33397991
51MP0005076_abnormal_cell_differentiation1.33266686
52MP0000343_altered_response_to1.32781871
53MP0000689_abnormal_spleen_morphology1.32356717
54MP0004270_analgesia1.31598812
55MP0001849_ear_inflammation1.31251902
56MP0001853_heart_inflammation1.30668638
57MP0003279_aneurysm1.29609787
58MP0003091_abnormal_cell_migration1.27980959
59MP0000465_gastrointestinal_hemorrhage1.27070564
60MP0002254_reproductive_system_inflammat1.25005470
61MP0005171_absent_coat_pigmentation1.23014462
62MP0004947_skin_inflammation1.20705254
63MP0004142_abnormal_muscle_tone1.20411637
64MP0003300_gastrointestinal_ulcer1.20187095
65MP0002722_abnormal_immune_system1.18117053
66MP0002396_abnormal_hematopoietic_system1.16338144
67MP0002429_abnormal_blood_cell1.16225875
68MP0002933_joint_inflammation1.14571170
69MP0004885_abnormal_endolymph1.14517505
70MP0003806_abnormal_nucleotide_metabolis1.13010718
71MP0003828_pulmonary_edema1.12437789
72MP0002229_neurodegeneration1.12143719
73MP0000604_amyloidosis1.12079829
74MP0003763_abnormal_thymus_physiology1.10994347
75MP0001533_abnormal_skeleton_physiology1.10132652
76MP0008057_abnormal_DNA_replication1.09996626
77MP0004858_abnormal_nervous_system1.09449544
78MP0001845_abnormal_inflammatory_respons1.06918230
79MP0001851_eye_inflammation1.06582001
80MP0008469_abnormal_protein_level1.06442542
81MP0009765_abnormal_xenobiotic_induced1.06015496
82MP0001486_abnormal_startle_reflex1.05837895
83MP0005390_skeleton_phenotype1.05673335
84MP0002877_abnormal_melanocyte_morpholog1.04899222
85MP0003566_abnormal_cell_adhesion1.04735295
86MP0003656_abnormal_erythrocyte_physiolo1.01688695
87MP0009764_decreased_sensitivity_to1.00925461
88MP0008004_abnormal_stomach_pH0.98541729
89MP0003632_abnormal_nervous_system0.97035152
90MP0003866_abnormal_defecation0.96698763
91MP0008438_abnormal_cutaneous_collagen0.95395054
92MP0005166_decreased_susceptibility_to0.94356009
93MP0000490_abnormal_crypts_of0.93454239
94MP0001485_abnormal_pinna_reflex0.92315328
95MP0004147_increased_porphyrin_level0.92287232
96MP0003453_abnormal_keratinocyte_physiol0.90365562
97MP0005023_abnormal_wound_healing0.89759575
98MP0010155_abnormal_intestine_physiology0.89124063
99MP0003950_abnormal_plasma_membrane0.87544603
100MP0001663_abnormal_digestive_system0.87191702
101MP0001529_abnormal_vocalization0.87068659
102MP0000383_abnormal_hair_follicle0.86865689
103MP0003724_increased_susceptibility_to0.86575001
104MP0001958_emphysema0.86296124
105MP0009046_muscle_twitch0.85857682
106MP0001905_abnormal_dopamine_level0.85441851
107MP0002166_altered_tumor_susceptibility0.85129144
108MP0003045_fibrosis0.85120668
109MP0005164_abnormal_response_to0.81780937
110MP0002064_seizures0.81728532
111MP0002332_abnormal_exercise_endurance0.81280571
112MP0004808_abnormal_hematopoietic_stem0.80480142
113MP0004185_abnormal_adipocyte_glucose0.80244840
114MP0003795_abnormal_bone_structure0.78558529
115MP0009763_increased_sensitivity_to0.78121948
116MP0002132_abnormal_respiratory_system0.78100281
117MP0000767_abnormal_smooth_muscle0.76947051
118MP0000249_abnormal_blood_vessel0.74963298
119MP0002138_abnormal_hepatobiliary_system0.74408373
120MP0002272_abnormal_nervous_system0.74102323
121MP0002095_abnormal_skin_pigmentation0.73211005
122MP0005666_abnormal_adipose_tissue0.73094404
123MP0001346_abnormal_lacrimal_gland0.72973348
124MP0003329_amyloid_beta_deposits0.72775835
125MP0004883_abnormal_blood_vessel0.72596604
126MP0000703_abnormal_thymus_morphology0.71286176
127MP0002796_impaired_skin_barrier0.71237430
128MP0005645_abnormal_hypothalamus_physiol0.71024141
129MP0002139_abnormal_hepatobiliary_system0.67299569
130MP0003448_altered_tumor_morphology0.66356314
131MP0003075_altered_response_to0.61807923
132MP0000778_abnormal_nervous_system0.60452252
133MP0008569_lethality_at_weaning0.56558913
134MP0000371_diluted_coat_color0.54616059
135MP0008874_decreased_physiological_sensi0.54421955
136MP0002998_abnormal_bone_remodeling0.54356950

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.49455773
2Recurrent bacterial skin infections (HP:0005406)4.13997325
3Eczematoid dermatitis (HP:0000976)4.03172009
4Neurofibrillary tangles (HP:0002185)3.97585293
5Degeneration of the lateral corticospinal tracts (HP:0002314)3.93756909
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.93756909
7Abnormality of macrophages (HP:0004311)3.90040100
8Recurrent skin infections (HP:0001581)3.82227633
9Retrobulbar optic neuritis (HP:0100654)3.68430468
10Optic neuritis (HP:0100653)3.68430468
11Parakeratosis (HP:0001036)3.61166798
12Chronic mucocutaneous candidiasis (HP:0002728)3.60436811
13Recurrent cutaneous fungal infections (HP:0011370)3.60436811
14Recurrent fungal infections (HP:0002841)3.52976222
15Supranuclear gaze palsy (HP:0000605)3.51934497
16Stomatitis (HP:0010280)3.38852012
17Myositis (HP:0100614)3.37990692
18Orchitis (HP:0100796)3.29411300
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.28925231
20Abnormality of glycolipid metabolism (HP:0010969)3.28925231
21Abnormality of liposaccharide metabolism (HP:0010968)3.28925231
22Vacuolated lymphocytes (HP:0001922)3.27159350
23Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.14892709
24Loss of speech (HP:0002371)3.01935982
25Elevated erythrocyte sedimentation rate (HP:0003565)3.00898166
26Slow saccadic eye movements (HP:0000514)2.99105564
27Increased cerebral lipofuscin (HP:0011813)2.98162322
28Systemic lupus erythematosus (HP:0002725)2.96640813
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.94331146
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.93586437
31Abnormality of the corticospinal tract (HP:0002492)2.91000348
32Onion bulb formation (HP:0003383)2.90678143
33Chronic otitis media (HP:0000389)2.85386595
34Akinesia (HP:0002304)2.81155618
35Hepatosplenomegaly (HP:0001433)2.80381285
36Vasculitis (HP:0002633)2.76906367
37Urinary glycosaminoglycan excretion (HP:0003541)2.72999482
38Mucopolysacchariduria (HP:0008155)2.72999482
39Sensory axonal neuropathy (HP:0003390)2.72126990
40Duplicated collecting system (HP:0000081)2.68362256
41Recurrent gram-negative bacterial infections (HP:0005420)2.66703719
42Cerebral inclusion bodies (HP:0100314)2.65052765
43Dysostosis multiplex (HP:0000943)2.64813217
44Recurrent viral infections (HP:0004429)2.61551408
45Meningitis (HP:0001287)2.59128884
46Spontaneous hematomas (HP:0007420)2.58048493
47Vertebral compression fractures (HP:0002953)2.55799971
48Gingival bleeding (HP:0000225)2.52998317
49Gingivitis (HP:0000230)2.51727920
50Panhypogammaglobulinemia (HP:0003139)2.50191496
51Chronic obstructive pulmonary disease (HP:0006510)2.48417132
52Obstructive lung disease (HP:0006536)2.48417132
53Gastrointestinal stroma tumor (HP:0100723)2.47704843
54Inflammation of the large intestine (HP:0002037)2.42910951
55Increased serum ferritin (HP:0003281)2.41861237
56J-shaped sella turcica (HP:0002680)2.38873433
57Cerebral aneurysm (HP:0004944)2.38087902
58Pulmonary infiltrates (HP:0002113)2.37467438
59Nuclear cataract (HP:0100018)2.37227583
60Colitis (HP:0002583)2.35984418
61Petechiae (HP:0000967)2.34806707
62Cellulitis (HP:0100658)2.32328909
63Interstitial pulmonary disease (HP:0006530)2.31823227
64Agammaglobulinemia (HP:0004432)2.27555550
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27452337
66Gastrointestinal inflammation (HP:0004386)2.26399706
67Pustule (HP:0200039)2.24979080
68Prolonged neonatal jaundice (HP:0006579)2.23754624
69Abnormality of the renal collecting system (HP:0004742)2.23153669
70Recurrent pneumonia (HP:0006532)2.22378043
71Axonal loss (HP:0003447)2.20953328
72Cheilitis (HP:0100825)2.19042443
73Broad face (HP:0000283)2.18816497
74Thoracic kyphosis (HP:0002942)2.18020349
75Gastrointestinal infarctions (HP:0005244)2.16620623
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16323111
77Osteomyelitis (HP:0002754)2.15057438
78Leukocytosis (HP:0001974)2.12348521
79White forelock (HP:0002211)2.12010509
80Increased IgE level (HP:0003212)2.11945749
81Malnutrition (HP:0004395)2.11405276
82Emphysema (HP:0002097)2.11076317
83Thin bony cortex (HP:0002753)2.10845753
84Premature skin wrinkling (HP:0100678)2.09841988
85* Spastic gait (HP:0002064)2.07588562
86Urticaria (HP:0001025)2.05122532
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03799400
88Abnormality of polysaccharide metabolism (HP:0011012)2.03799400
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03799400
90Eosinophilia (HP:0001880)2.02973919
91Mediastinal lymphadenopathy (HP:0100721)2.02770396
92Purpura (HP:0000979)2.01808178
93Stridor (HP:0010307)2.01638608
94Hemorrhage of the eye (HP:0011885)2.01262575
95T lymphocytopenia (HP:0005403)2.00933887
96Encephalitis (HP:0002383)2.00838440
97Cervical subluxation (HP:0003308)2.00421981
98Amyloidosis (HP:0011034)1.99837847
99Peripheral demyelination (HP:0011096)1.99669163
100Neuronal loss in central nervous system (HP:0002529)1.97033332
101Congenital ichthyosiform erythroderma (HP:0007431)1.95588477
102Depressed nasal tip (HP:0000437)1.95243596
103Autoimmune thrombocytopenia (HP:0001973)1.95097028
104Polygenic inheritance (HP:0010982)1.94789812
105Distal lower limb amyotrophy (HP:0008944)1.94682438
106Hemoptysis (HP:0002105)1.93761163
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93738942
108Upper motor neuron abnormality (HP:0002127)1.93317611
109Abnormality of the nasal mucosa (HP:0000433)1.92985830
110Progressive neurologic deterioration (HP:0002344)1.90132231
111Abnormality of the thoracic spine (HP:0100711)1.88413841
112Hypergammaglobulinemia (HP:0010702)1.88236566
113Leukopenia (HP:0001882)1.87339303
114Achilles tendon contracture (HP:0001771)1.87300440
115Restrictive lung disease (HP:0002091)1.86305975
116Abnormality of T cell number (HP:0011839)1.86106879
117Chromsome breakage (HP:0040012)1.85604279
118Peripheral hypomyelination (HP:0007182)1.85520532
119Abnormality of eosinophils (HP:0001879)1.84987413
120Albinism (HP:0001022)1.84435848
121Bone pain (HP:0002653)1.83845732
122Increased IgM level (HP:0003496)1.83738621
123Hypertensive crisis (HP:0100735)1.83465008
124Myocardial infarction (HP:0001658)1.82238767
125Abnormality of iron homeostasis (HP:0011031)1.82122506
126Spondylolisthesis (HP:0003302)1.81987324
127Epistaxis (HP:0000421)1.81191935
128Joint stiffness (HP:0001387)1.81127288
129Keratoconjunctivitis sicca (HP:0001097)1.80603148
130Abnormality of the fingertips (HP:0001211)1.80091867
131Hyperacusis (HP:0010780)1.79997114
132Increased connective tissue (HP:0009025)1.79803031
133Erythroderma (HP:0001019)1.79545026
134Submucous cleft hard palate (HP:0000176)1.78930327
135Ocular albinism (HP:0001107)1.78584118
136Distal lower limb muscle weakness (HP:0009053)1.78261281
137Disinhibition (HP:0000734)1.77716209
138Hypertriglyceridemia (HP:0002155)1.77640691
139Spastic tetraparesis (HP:0001285)1.77493098
140Prolonged bleeding time (HP:0003010)1.77052841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.74786693
2MAP4K13.27644322
3TRIB33.23013447
4STK393.07814419
5IRAK42.48303668
6SIK12.43554067
7MAP2K32.28551931
8MAP3K112.26778052
9ERN12.25931831
10OXSR12.25131633
11MAP3K132.19219792
12BLK2.17418507
13IRAK32.15969166
14CLK12.13123620
15NME22.09679840
16SMG12.08744477
17MAP3K142.07856712
18PKN12.04891534
19TNIK1.92848066
20ICK1.92545398
21IKBKE1.89464110
22TAOK21.86153846
23TYK21.86108241
24SIK21.83052881
25TAOK31.78797517
26KIT1.77838274
27TAOK11.74173710
28MAP3K31.72823188
29TESK21.70681946
30FES1.70150352
31RIPK11.60542784
32IKBKB1.60286489
33BTK1.55257768
34PRPF4B1.49909340
35RIPK41.42658099
36EPHA31.40279708
37IRAK11.37635938
38CSK1.36749521
39HCK1.36587467
40TBK11.36458219
41CSF1R1.36429040
42SIK31.35355835
43PRKD21.34045688
44JAK11.32762394
45CDC42BPA1.28322429
46TXK1.27462924
47MAP3K11.26443494
48CDK121.21776752
49CDK191.21699118
50TESK11.21060337
51LCK1.13040668
52DDR21.10163643
53ITK1.08858317
54FGR1.05787119
55CSNK1A1L1.02990209
56ADRBK21.02902694
57TGFBR21.01386943
58SYK0.97776210
59BRD40.97633325
60FGFR40.97411509
61TTN0.97364411
62YES10.95942948
63WNK10.94788299
64MARK20.90035211
65PIM20.89600160
66PKN20.88616426
67MAPK150.88506078
68PRKCQ0.88279623
69RPS6KL10.83518104
70RPS6KC10.83518104
71LYN0.81971646
72NEK60.81856919
73RPS6KA20.81573359
74CSNK1G30.81003969
75UHMK10.80104723
76MAP3K60.78867108
77ZAP700.78390750
78PAK40.78056029
79WNK40.77970864
80BCR0.77580305
81TRPM70.73641943
82IRAK20.72008873
83PBK0.71548244
84GRK70.70435269
85MET0.70261888
86MARK30.69997224
87PDGFRA0.69079491
88CAMK1G0.66663624
89RPS6KA60.66015902
90BMX0.65046076
91DYRK1B0.64764943
92BMPR20.63500915
93ABL20.62642631
94MAP3K100.61565207
95JAK30.61160904
96KDR0.60174116
97MAPK70.59621062
98SGK2230.59375504
99SGK4940.59375504
100TLK10.58595642
101FYN0.58494772
102TNK20.58325509
103PAK60.57596008
104KSR20.56758670
105MAPK110.56128276
106STK100.55941273
107PIK3CG0.55300980
108JAK20.55197763
109CSNK1G10.55142256
110ARAF0.55103964
111ABL10.54456329
112TEC0.53656922
113MTOR0.52965960
114MAP2K20.52787329
115PRKD10.52728551
116MAPK120.52633474
117CHUK0.50945490
118MOS0.50888372
119PDPK10.50586241
120PDK10.49786767
121CSNK1G20.47939624
122PIM10.46658900
123EPHA20.44930672
124STK40.44582854
125CAMK1D0.44435117
126MAPK40.43641067
127PRKG20.43582258
128STK110.43496465
129CDK40.43316091
130CDK60.42551113
131EEF2K0.42209990
132HIPK20.41781404
133CSNK1D0.41469522
134MAPKAPK50.40951669
135GRK60.40899686
136STK380.40219103
137MAPKAPK20.40058793
138ROCK20.39814825
139MAP2K60.39779455
140MAP3K80.38998647
141EIF2AK20.38973711
142MAP3K70.38737952
143CAMK2D0.37524359
144PTK60.35142221
145PRKCH0.34759630
146ALK0.33313282
147MATK0.32136825
148CDK50.31786535
149GSK3A0.31357543
150NLK0.31041145
151RPS6KA50.29826725

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.37491322
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.08868189
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58639157
4Other glycan degradation_Homo sapiens_hsa005112.54372574
5Primary immunodeficiency_Homo sapiens_hsa053402.48555449
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.46399722
7Lysosome_Homo sapiens_hsa041422.25997933
8Fatty acid elongation_Homo sapiens_hsa000622.22296658
9B cell receptor signaling pathway_Homo sapiens_hsa046622.15774121
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.93998492
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92536312
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.89869565
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86912374
14Hematopoietic cell lineage_Homo sapiens_hsa046401.76505729
15Osteoclast differentiation_Homo sapiens_hsa043801.75672415
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74952620
17Malaria_Homo sapiens_hsa051441.74698970
18Leishmaniasis_Homo sapiens_hsa051401.72060355
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71617711
20Ether lipid metabolism_Homo sapiens_hsa005651.70670127
21Sphingolipid metabolism_Homo sapiens_hsa006001.67014283
22Staphylococcus aureus infection_Homo sapiens_hsa051501.66460547
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.60720254
24Measles_Homo sapiens_hsa051621.50411970
25T cell receptor signaling pathway_Homo sapiens_hsa046601.50238928
26Rheumatoid arthritis_Homo sapiens_hsa053231.50176357
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48786992
28Allograft rejection_Homo sapiens_hsa053301.43046514
29Chemokine signaling pathway_Homo sapiens_hsa040621.40275252
30VEGF signaling pathway_Homo sapiens_hsa043701.32287096
31Tuberculosis_Homo sapiens_hsa051521.30752069
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.29832776
33ABC transporters_Homo sapiens_hsa020101.29532042
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28965843
35Bladder cancer_Homo sapiens_hsa052191.28229778
36Graft-versus-host disease_Homo sapiens_hsa053321.28168733
37Viral myocarditis_Homo sapiens_hsa054161.27707167
38Non-homologous end-joining_Homo sapiens_hsa034501.25712640
39Vitamin B6 metabolism_Homo sapiens_hsa007501.23267750
40Pertussis_Homo sapiens_hsa051331.22371420
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.20070332
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19794023
43Antigen processing and presentation_Homo sapiens_hsa046121.18425853
44Legionellosis_Homo sapiens_hsa051341.17576730
45Hepatitis C_Homo sapiens_hsa051601.15757313
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07521304
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06892215
48Pancreatic cancer_Homo sapiens_hsa052121.06317177
49Non-small cell lung cancer_Homo sapiens_hsa052231.04672202
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00978592
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00858900
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99700228
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.97188271
54Notch signaling pathway_Homo sapiens_hsa043300.96668431
55Phagosome_Homo sapiens_hsa041450.96380778
56Prion diseases_Homo sapiens_hsa050200.96316950
57Autoimmune thyroid disease_Homo sapiens_hsa053200.94676427
58Type I diabetes mellitus_Homo sapiens_hsa049400.94036028
59Inositol phosphate metabolism_Homo sapiens_hsa005620.93543542
60Histidine metabolism_Homo sapiens_hsa003400.92358214
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91810876
62Collecting duct acid secretion_Homo sapiens_hsa049660.90488289
63Endocytosis_Homo sapiens_hsa041440.89523619
64Amoebiasis_Homo sapiens_hsa051460.87677274
65Acute myeloid leukemia_Homo sapiens_hsa052210.87180184
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.86299190
67Prolactin signaling pathway_Homo sapiens_hsa049170.85910318
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85776851
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.85077917
70Salmonella infection_Homo sapiens_hsa051320.84727682
71Axon guidance_Homo sapiens_hsa043600.83322695
72Apoptosis_Homo sapiens_hsa042100.82943776
73Herpes simplex infection_Homo sapiens_hsa051680.80388054
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79694824
75Fructose and mannose metabolism_Homo sapiens_hsa000510.77906455
76Influenza A_Homo sapiens_hsa051640.75427357
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.75115898
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74653740
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.73450661
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72046956
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.71680576
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71078712
83Asthma_Homo sapiens_hsa053100.70474171
84HTLV-I infection_Homo sapiens_hsa051660.69610376
85Platelet activation_Homo sapiens_hsa046110.69363950
86Linoleic acid metabolism_Homo sapiens_hsa005910.66465407
87mTOR signaling pathway_Homo sapiens_hsa041500.66261702
88Galactose metabolism_Homo sapiens_hsa000520.65990652
89Endometrial cancer_Homo sapiens_hsa052130.65596706
90ErbB signaling pathway_Homo sapiens_hsa040120.65569889
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64928258
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64526635
93Shigellosis_Homo sapiens_hsa051310.64490029
94Viral carcinogenesis_Homo sapiens_hsa052030.63990344
95Toxoplasmosis_Homo sapiens_hsa051450.63618498
96Pentose phosphate pathway_Homo sapiens_hsa000300.63565823
97Fanconi anemia pathway_Homo sapiens_hsa034600.63347058
98TNF signaling pathway_Homo sapiens_hsa046680.61704276
99Lysine degradation_Homo sapiens_hsa003100.61655053
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.60693616
101Small cell lung cancer_Homo sapiens_hsa052220.60056996
102GnRH signaling pathway_Homo sapiens_hsa049120.59924166
103HIF-1 signaling pathway_Homo sapiens_hsa040660.56712355
104Homologous recombination_Homo sapiens_hsa034400.54701034
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54289312
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54009282
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53619500
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52476432
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52431775
110Arachidonic acid metabolism_Homo sapiens_hsa005900.52267917
111Vibrio cholerae infection_Homo sapiens_hsa051100.52173566
112Insulin resistance_Homo sapiens_hsa049310.52150052
113Regulation of autophagy_Homo sapiens_hsa041400.51852332
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51700817
115Type II diabetes mellitus_Homo sapiens_hsa049300.51599214
116Hepatitis B_Homo sapiens_hsa051610.51313118
117Arginine and proline metabolism_Homo sapiens_hsa003300.50204010
118Chronic myeloid leukemia_Homo sapiens_hsa052200.48680357
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47922939
120Renal cell carcinoma_Homo sapiens_hsa052110.46198610
121Glioma_Homo sapiens_hsa052140.45701561
122Prostate cancer_Homo sapiens_hsa052150.44084240
123MAPK signaling pathway_Homo sapiens_hsa040100.44006504
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42894647
125Morphine addiction_Homo sapiens_hsa050320.42464952
126Sulfur relay system_Homo sapiens_hsa041220.42269673
127Insulin signaling pathway_Homo sapiens_hsa049100.42258463
128Choline metabolism in cancer_Homo sapiens_hsa052310.41654389
129Proteoglycans in cancer_Homo sapiens_hsa052050.40444391
130Caffeine metabolism_Homo sapiens_hsa002320.39971725
131Vitamin digestion and absorption_Homo sapiens_hsa049770.39072841
132Dorso-ventral axis formation_Homo sapiens_hsa043200.38234979
133Epstein-Barr virus infection_Homo sapiens_hsa051690.38169610
134Ras signaling pathway_Homo sapiens_hsa040140.38025292
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36221156
136African trypanosomiasis_Homo sapiens_hsa051430.36070217
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35114815
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.34979322
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33625363

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