APBB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.92396447
2axon ensheathment in central nervous system (GO:0032291)5.92396447
3long-chain fatty acid biosynthetic process (GO:0042759)3.55254933
4fatty acid elongation (GO:0030497)3.54640759
5myelination (GO:0042552)3.44218349
6negative regulation of neurotransmitter secretion (GO:0046929)3.42859441
7axon ensheathment (GO:0008366)3.41532309
8ensheathment of neurons (GO:0007272)3.41532309
9negative regulation of protein localization to cell surface (GO:2000009)3.37140912
10negative regulation of neurotransmitter transport (GO:0051589)3.35652480
11establishment of mitochondrion localization (GO:0051654)3.26595526
12postsynaptic membrane organization (GO:0001941)3.23429733
13retina vasculature morphogenesis in camera-type eye (GO:0061299)3.04389287
14paraxial mesoderm development (GO:0048339)3.00848026
15neuron cell-cell adhesion (GO:0007158)2.95093974
16lymph vessel development (GO:0001945)2.91643735
17axonal fasciculation (GO:0007413)2.91515095
18peptidyl-tyrosine autophosphorylation (GO:0038083)2.91225476
19neuron remodeling (GO:0016322)2.86771704
20eye photoreceptor cell differentiation (GO:0001754)2.84528260
21photoreceptor cell differentiation (GO:0046530)2.84528260
22neuron recognition (GO:0008038)2.81035523
23import into cell (GO:0098657)2.79504855
24limb bud formation (GO:0060174)2.78476055
25dendrite morphogenesis (GO:0048813)2.75833186
26presynaptic membrane organization (GO:0097090)2.71090576
27cerebral cortex radially oriented cell migration (GO:0021799)2.70983242
28negative regulation of axon extension involved in axon guidance (GO:0048843)2.70810688
29presynaptic membrane assembly (GO:0097105)2.70372051
30membrane assembly (GO:0071709)2.69764678
31lymphangiogenesis (GO:0001946)2.69329767
32pyrimidine nucleobase catabolic process (GO:0006208)2.68018050
33apical protein localization (GO:0045176)2.62966877
34nerve growth factor signaling pathway (GO:0038180)2.61783622
35artery development (GO:0060840)2.60792469
36response to redox state (GO:0051775)2.57972282
37glomerular filtration (GO:0003094)2.55263398
38regulation of axon extension involved in axon guidance (GO:0048841)2.55172342
39vocalization behavior (GO:0071625)2.51739154
40ganglion development (GO:0061548)2.49086584
41myelination in peripheral nervous system (GO:0022011)2.47982327
42peripheral nervous system axon ensheathment (GO:0032292)2.47982327
43negative regulation of axon guidance (GO:1902668)2.46965786
44asymmetric protein localization (GO:0008105)2.46530416
45negative regulation of Rho protein signal transduction (GO:0035024)2.45696659
46lateral sprouting from an epithelium (GO:0060601)2.44819601
47calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44572755
48hemidesmosome assembly (GO:0031581)2.43071987
49regulation of axon guidance (GO:1902667)2.41583093
50auditory behavior (GO:0031223)2.41123185
51negative regulation of chondrocyte differentiation (GO:0032331)2.38870867
52calcium-mediated signaling using intracellular calcium source (GO:0035584)2.37197046
53Rap protein signal transduction (GO:0032486)2.35928431
54regulation of collateral sprouting (GO:0048670)2.34382817
55renal filtration (GO:0097205)2.33580427
56positive regulation of oligodendrocyte differentiation (GO:0048714)2.32968729
57cholesterol biosynthetic process (GO:0006695)2.32656596
58myelin maintenance (GO:0043217)2.31877688
59adhesion of symbiont to host cell (GO:0044650)2.30242960
60virion attachment to host cell (GO:0019062)2.30242960
61notochord development (GO:0030903)2.29811483
62negative regulation of axonogenesis (GO:0050771)2.29725242
63dermatan sulfate biosynthetic process (GO:0030208)2.29007071
64regulation of pigment cell differentiation (GO:0050932)2.28969265
65positive regulation of synapse assembly (GO:0051965)2.26927265
66regulation of hippo signaling (GO:0035330)2.26895820
67neuron projection extension (GO:1990138)2.26841306
68response to lipoprotein particle (GO:0055094)2.26335963
69negative regulation of axon extension (GO:0030517)2.25372039
70vascular endothelial growth factor signaling pathway (GO:0038084)2.25091022
71glycerophospholipid catabolic process (GO:0046475)2.24499256
72negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.23984949
73embryonic foregut morphogenesis (GO:0048617)2.22978342
74endothelium development (GO:0003158)2.22877708
75retinal ganglion cell axon guidance (GO:0031290)2.22214944
76limb development (GO:0060173)2.21173893
77appendage development (GO:0048736)2.21173893
78cell migration in hindbrain (GO:0021535)2.19806083
79L-amino acid import (GO:0043092)2.19727437
80dendritic spine morphogenesis (GO:0060997)2.19547471
81central nervous system projection neuron axonogenesis (GO:0021952)2.19303450
82synapse assembly (GO:0007416)2.19246295
83regulation of cell communication by electrical coupling (GO:0010649)2.18072302
84response to methylmercury (GO:0051597)2.16295772
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.16268607
86cell migration involved in sprouting angiogenesis (GO:0002042)2.15053769
87extracellular matrix assembly (GO:0085029)2.14376959
88ephrin receptor signaling pathway (GO:0048013)2.13442355
89chondrocyte proliferation (GO:0035988)2.12738131
90regulation of synapse assembly (GO:0051963)2.12565958
91axon extension (GO:0048675)2.11829659
92glomerular basement membrane development (GO:0032836)2.11457374
93astrocyte development (GO:0014002)2.11429738
94hippo signaling (GO:0035329)2.11061116
95synaptic vesicle maturation (GO:0016188)2.10331629
96neurofilament cytoskeleton organization (GO:0060052)2.09610711
97neuron projection extension involved in neuron projection guidance (GO:1902284)2.09329931
98axon extension involved in axon guidance (GO:0048846)2.09329931
99sterol biosynthetic process (GO:0016126)2.09188180
100neuronal action potential propagation (GO:0019227)2.08640731
101peripheral nervous system development (GO:0007422)2.08405207
102protein localization to endosome (GO:0036010)2.08341830
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.08248686
104negative chemotaxis (GO:0050919)2.06828185
105establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.06523227
106mitochondrion transport along microtubule (GO:0047497)2.06523227
107dermatan sulfate metabolic process (GO:0030205)2.06482148
108endothelial cell morphogenesis (GO:0001886)2.06427006
109negative regulation of cartilage development (GO:0061037)2.06270481
110peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.05799310
111regulation of phospholipid biosynthetic process (GO:0071071)2.04497445
112membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.04360466
113positive regulation of vasculogenesis (GO:2001214)2.03846435
114camera-type eye morphogenesis (GO:0048593)2.03781036
115positive regulation of smooth muscle cell migration (GO:0014911)2.03675281
116substantia nigra development (GO:0021762)2.03296183
117generation of neurons (GO:0048699)2.02853394
118isoprenoid biosynthetic process (GO:0008299)2.02590596
119transmission of nerve impulse (GO:0019226)2.02253156
120cell-cell signaling involved in cell fate commitment (GO:0045168)2.02031940
121myelin assembly (GO:0032288)2.01199229
122G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.00916681
123smooth muscle tissue development (GO:0048745)2.00783722
124positive regulation of action potential (GO:0045760)2.00017797
125clathrin coat assembly (GO:0048268)1.99685254
126nucleobase catabolic process (GO:0046113)1.99389157
127regulation of transforming growth factor beta2 production (GO:0032909)1.98573135
128protein heterotrimerization (GO:0070208)1.98539755
129regulation of short-term neuronal synaptic plasticity (GO:0048172)1.98283650
130developmental induction (GO:0031128)1.98013405
131cell adhesion mediated by integrin (GO:0033627)1.97712168
132neuronal ion channel clustering (GO:0045161)1.97701312
133Golgi to plasma membrane protein transport (GO:0043001)1.97624789
134mechanosensory behavior (GO:0007638)1.97619156
135protein localization to synapse (GO:0035418)1.97520713
136protein targeting to plasma membrane (GO:0072661)1.97183584
137cellular response to monoamine stimulus (GO:0071868)1.95880477
138cellular response to catecholamine stimulus (GO:0071870)1.95880477
139response to catecholamine (GO:0071869)1.95316697
140response to monoamine (GO:0071867)1.95316697
141central nervous system neuron axonogenesis (GO:0021955)1.95270136
142negative regulation of oligodendrocyte differentiation (GO:0048715)1.95104899
143cellular response to epinephrine stimulus (GO:0071872)1.94834982
144lung-associated mesenchyme development (GO:0060484)1.94804436
145cerebral cortex cell migration (GO:0021795)1.94398589
146dendrite development (GO:0016358)1.93675457
147negative regulation of synaptic transmission, GABAergic (GO:0032229)1.93500985
148organ induction (GO:0001759)1.93156522
149gamma-aminobutyric acid transport (GO:0015812)1.92872295
150homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)1.92258802
151nonmotile primary cilium assembly (GO:0035058)1.91920949
152synapse organization (GO:0050808)1.91514976
153collagen fibril organization (GO:0030199)1.91026450
154response to auditory stimulus (GO:0010996)1.89203529
155embryonic retina morphogenesis in camera-type eye (GO:0060059)1.88707086
156mesenchymal-epithelial cell signaling (GO:0060638)1.88352985
157mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.88297117
158branching involved in salivary gland morphogenesis (GO:0060445)1.88193153
159layer formation in cerebral cortex (GO:0021819)1.88190174
160negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)1.86172334
161establishment of tissue polarity (GO:0007164)1.85838795
162establishment of planar polarity (GO:0001736)1.85838795
163spinal cord development (GO:0021510)1.85369236
164anterior/posterior axis specification, embryo (GO:0008595)1.84947532
165negative regulation of keratinocyte proliferation (GO:0010839)1.83669338
166C4-dicarboxylate transport (GO:0015740)1.83000287
167developmental cell growth (GO:0048588)1.82818060
168dorsal/ventral axis specification (GO:0009950)1.81907552
169establishment of nucleus localization (GO:0040023)1.81154328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.44694945
2EZH2_22144423_ChIP-Seq_EOC_Human2.73152001
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35482990
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30656961
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28541779
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18078514
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.12073383
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11814227
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05951170
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05951170
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.04618145
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04175967
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.02394818
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02195593
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.01040286
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99975037
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98269740
18AR_21572438_ChIP-Seq_LNCaP_Human1.95159946
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.93650244
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89531615
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88071695
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.86712193
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83569626
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83521220
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82125243
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80922089
27TAF15_26573619_Chip-Seq_HEK293_Human1.80595177
28* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78265291
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.77724837
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76531749
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.74958577
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.74675469
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72094502
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68574724
35P300_19829295_ChIP-Seq_ESCs_Human1.64579565
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64534929
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.63826592
38* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61505753
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.61219990
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.58812273
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.57638778
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57530310
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56785397
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56785397
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54566904
46* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53613368
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52597471
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.52265254
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51810552
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50049348
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48597446
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.47210154
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45911449
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45844470
55ER_23166858_ChIP-Seq_MCF-7_Human1.45034568
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41909494
57* AHR_22903824_ChIP-Seq_MCF-7_Human1.41280298
58* ARNT_22903824_ChIP-Seq_MCF-7_Human1.38303342
59TP53_18474530_ChIP-ChIP_U2OS_Human1.36673905
60ZNF274_21170338_ChIP-Seq_K562_Hela1.34126487
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.33221989
62TBX3_20139965_ChIP-Seq_MESCs_Mouse1.33137133
63* STAT3_23295773_ChIP-Seq_U87_Human1.32481371
64DROSHA_22980978_ChIP-Seq_HELA_Human1.32292673
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31266688
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30578668
67* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29901189
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29542676
69CJUN_26792858_Chip-Seq_BT549_Human1.28086205
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27979442
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.27724457
72* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25906884
73SOX9_26525672_Chip-Seq_HEART_Mouse1.24117938
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23301010
75* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22580078
76FUS_26573619_Chip-Seq_HEK293_Human1.21192629
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19451627
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19259174
79EWS_26573619_Chip-Seq_HEK293_Human1.18537076
80* ISL1_27105846_Chip-Seq_CPCs_Mouse1.18068642
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16963132
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15815836
83RNF2_27304074_Chip-Seq_NSC_Mouse1.15726334
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14074210
85* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13603765
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.13214900
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.13042664
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11033227
89VDR_22108803_ChIP-Seq_LS180_Human1.10637092
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09455744
91TCF4_23295773_ChIP-Seq_U87_Human1.09119573
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.08666334
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08157571
94* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07613163
95IGF1R_20145208_ChIP-Seq_DFB_Human1.06671741
96* AR_25329375_ChIP-Seq_VCAP_Human1.06350080
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06195529
98* TP53_16413492_ChIP-PET_HCT116_Human1.05873605
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05796280
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.05544652
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.04572339
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04389355
103JUN_21703547_ChIP-Seq_K562_Human1.04273893
104* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04248529
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02271400
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02056596
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01926613
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01774739
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.00379602
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00229282
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.99389697
112KDM2B_26808549_Chip-Seq_REH_Human0.99376113
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.98411503
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.98215591
115CMYC_18555785_Chip-Seq_ESCs_Mouse0.97329193
116REST_21632747_ChIP-Seq_MESCs_Mouse0.96397765
117* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96060062
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95861999
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95452453
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94866674
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.92742630
122* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91595520
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91196558
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91044150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation2.99232386
2MP0004270_analgesia2.89792403
3MP0003950_abnormal_plasma_membrane2.74770854
4MP0000920_abnormal_myelination2.66442454
5MP0004272_abnormal_basement_membrane2.66044900
6MP0005623_abnormal_meninges_morphology2.57227964
7MP0008438_abnormal_cutaneous_collagen2.50259428
8MP0003880_abnormal_central_pattern2.49390270
9MP0010030_abnormal_orbit_morphology2.30389767
10MP0001879_abnormal_lymphatic_vessel2.28367449
11MP0000778_abnormal_nervous_system2.26581836
12MP0005503_abnormal_tendon_morphology2.25616494
13MP0003941_abnormal_skin_development2.00868059
14MP0010368_abnormal_lymphatic_system1.91969573
15MP0002734_abnormal_mechanical_nocicepti1.87646526
16MP0004859_abnormal_synaptic_plasticity1.75201858
17MP0005409_darkened_coat_color1.72547308
18MP0001299_abnormal_eye_distance/1.70895033
19MP0001486_abnormal_startle_reflex1.65146453
20MP0001188_hyperpigmentation1.63469370
21MP0002272_abnormal_nervous_system1.59201337
22MP0000751_myopathy1.58699866
23MP0003634_abnormal_glial_cell1.57768291
24MP0006276_abnormal_autonomic_nervous1.55994731
25MP0002295_abnormal_pulmonary_circulatio1.55738038
26MP0003690_abnormal_glial_cell1.52773893
27MP0004742_abnormal_vestibular_system1.52208339
28MP0003635_abnormal_synaptic_transmissio1.50150881
29MP0005257_abnormal_intraocular_pressure1.46839135
30MP0002064_seizures1.43535976
31MP0002735_abnormal_chemical_nociception1.41943031
32MP0001905_abnormal_dopamine_level1.40952853
33MP0009780_abnormal_chondrocyte_physiolo1.39971900
34MP0005423_abnormal_somatic_nervous1.38954410
35MP0004134_abnormal_chest_morphology1.38066137
36MP0003705_abnormal_hypodermis_morpholog1.37601451
37MP0009384_cardiac_valve_regurgitation1.34294624
38MP0003136_yellow_coat_color1.33847685
39MP0000537_abnormal_urethra_morphology1.33468186
40MP0005248_abnormal_Harderian_gland1.33160970
41MP0009046_muscle_twitch1.32836518
42MP0000762_abnormal_tongue_morphology1.30599145
43MP0000534_abnormal_ureter_morphology1.30036475
44MP0000049_abnormal_middle_ear1.29242231
45MP0001958_emphysema1.28895997
46MP0002108_abnormal_muscle_morphology1.27991256
47MP0003385_abnormal_body_wall1.26896040
48MP0002063_abnormal_learning/memory/cond1.26731676
49MP0001984_abnormal_olfaction1.26036469
50MP0004133_heterotaxia1.24559130
51MP0004145_abnormal_muscle_electrophysio1.24078011
52MP0000749_muscle_degeneration1.22407567
53MP0009250_abnormal_appendicular_skeleto1.21417590
54MP0004484_altered_response_of1.21058873
55MP0003890_abnormal_embryonic-extraembry1.20087975
56MP0002572_abnormal_emotion/affect_behav1.19943592
57MP0005187_abnormal_penis_morphology1.19551063
58MP0003279_aneurysm1.19184411
59MP0002234_abnormal_pharynx_morphology1.17329524
60MP0004858_abnormal_nervous_system1.17215899
61MP0001529_abnormal_vocalization1.15935370
62MP0009745_abnormal_behavioral_response1.15650222
63MP0004885_abnormal_endolymph1.15037159
64MP0002067_abnormal_sensory_capabilities1.14807294
65MP0002184_abnormal_innervation1.14413689
66MP0002697_abnormal_eye_size1.14258233
67MP0003942_abnormal_urinary_system1.14149716
68MP0001177_atelectasis1.13626988
69MP0002233_abnormal_nose_morphology1.13356813
70MP0003091_abnormal_cell_migration1.11834943
71MP0003122_maternal_imprinting1.10573952
72MP0000428_abnormal_craniofacial_morphol1.09721996
73MP0002882_abnormal_neuron_morphology1.08846303
74MP0003119_abnormal_digestive_system1.08781739
75MP0001293_anophthalmia1.08311985
76MP0000579_abnormal_nail_morphology1.08100776
77MP0000383_abnormal_hair_follicle1.06702276
78MP0004036_abnormal_muscle_relaxation1.04817413
79MP0003566_abnormal_cell_adhesion1.04275233
80MP0001970_abnormal_pain_threshold1.04272021
81MP0004085_abnormal_heartbeat1.03868123
82MP0000647_abnormal_sebaceous_gland1.03609653
83MP0001485_abnormal_pinna_reflex1.03580890
84MP0001440_abnormal_grooming_behavior1.02138333
85MP0003632_abnormal_nervous_system1.01505113
86MP0000955_abnormal_spinal_cord1.00832496
87MP0005595_abnormal_vascular_smooth0.98797200
88MP0003631_nervous_system_phenotype0.97618961
89MP0008789_abnormal_olfactory_epithelium0.97498779
90MP0000372_irregular_coat_pigmentation0.97378353
91MP0009053_abnormal_anal_canal0.97109557
92MP0004142_abnormal_muscle_tone0.96521778
93MP0005167_abnormal_blood-brain_barrier0.96498413
94MP0005508_abnormal_skeleton_morphology0.96211752
95MP0002133_abnormal_respiratory_system0.95503294
96MP0005388_respiratory_system_phenotype0.95503294
97MP0003935_abnormal_craniofacial_develop0.94989848
98MP0002972_abnormal_cardiac_muscle0.94488978
99MP0003633_abnormal_nervous_system0.93652308
100MP0003828_pulmonary_edema0.93447377
101MP0001968_abnormal_touch/_nociception0.93232659
102MP0004084_abnormal_cardiac_muscle0.92463139
103MP0003937_abnormal_limbs/digits/tail_de0.92298899
104MP0004924_abnormal_behavior0.92064835
105MP0005386_behavior/neurological_phenoty0.92064835
106MP0008775_abnormal_heart_ventricle0.91576958
107MP0002736_abnormal_nociception_after0.90798774
108MP0003861_abnormal_nervous_system0.90638950
109MP0002229_neurodegeneration0.90637056
110MP0003755_abnormal_palate_morphology0.90625885
111MP0002752_abnormal_somatic_nervous0.88943516
112MP0003724_increased_susceptibility_to0.88770445
113MP0002733_abnormal_thermal_nociception0.88403788
114MP0002092_abnormal_eye_morphology0.87859431
115MP0005620_abnormal_muscle_contractility0.87725224
116MP0004215_abnormal_myocardial_fiber0.87062706
117MP0000026_abnormal_inner_ear0.86825488
118MP0002116_abnormal_craniofacial_bone0.86098928
119MP0005551_abnormal_eye_electrophysiolog0.85905985
120MP0002938_white_spotting0.85824568
121MP0005164_abnormal_response_to0.85708663
122MP0004883_abnormal_blood_vessel0.85656468
123MP0001286_abnormal_eye_development0.85434367
124MP0003329_amyloid_beta_deposits0.85225781
125MP0003045_fibrosis0.84706241
126MP0000462_abnormal_digestive_system0.84649448
127MP0006138_congestive_heart_failure0.84310864
128MP0005394_taste/olfaction_phenotype0.83539547
129MP0005499_abnormal_olfactory_system0.83539547
130MP0005195_abnormal_posterior_eye0.83224146
131MP0000767_abnormal_smooth_muscle0.82923129
132MP0002896_abnormal_bone_mineralization0.82825679
133MP0002282_abnormal_trachea_morphology0.82432172
134MP0002751_abnormal_autonomic_nervous0.81135032
135MP0009379_abnormal_foot_pigmentation0.80541058
136MP0002066_abnormal_motor_capabilities/c0.80308011
137MP0000013_abnormal_adipose_tissue0.80163907
138MP0005275_abnormal_skin_tensile0.80018352
139MP0000566_synostosis0.79572681
140MP0002152_abnormal_brain_morphology0.79542773
141MP0005369_muscle_phenotype0.79541478
142MP0006072_abnormal_retinal_apoptosis0.79359854
143MP0005391_vision/eye_phenotype0.79286900
144MP0010678_abnormal_skin_adnexa0.78883638
145MP0000432_abnormal_head_morphology0.78410382
146MP0000427_abnormal_hair_cycle0.77324268
147MP0000631_abnormal_neuroendocrine_gland0.76352796
148MP0005646_abnormal_pituitary_gland0.75989363
149MP0002557_abnormal_social/conspecific_i0.75277913
150MP0000467_abnormal_esophagus_morphology0.75005155
151MP0002932_abnormal_joint_morphology0.74327303

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.59281838
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.59281838
3Abnormality of the corticospinal tract (HP:0002492)3.51262191
4Termporal pattern (HP:0011008)3.33943042
5Insidious onset (HP:0003587)3.33943042
6Neurofibrillary tangles (HP:0002185)3.14842703
7Premature rupture of membranes (HP:0001788)3.04712203
8Aplasia involving bones of the upper limbs (HP:0009823)2.74726508
9Aplasia of the phalanges of the hand (HP:0009802)2.74726508
10Aplasia involving bones of the extremities (HP:0009825)2.74726508
11Onion bulb formation (HP:0003383)2.73910802
12Retinal dysplasia (HP:0007973)2.65634995
13Sensory axonal neuropathy (HP:0003390)2.60301398
14Muscle fiber splitting (HP:0003555)2.54536573
15Scanning speech (HP:0002168)2.52770116
16Parakeratosis (HP:0001036)2.52543372
17Hypoplasia of the iris (HP:0007676)2.52308329
18Action tremor (HP:0002345)2.42033390
19Abnormality of dentin (HP:0010299)2.41608515
20Segmental peripheral demyelination/remyelination (HP:0003481)2.41331309
21Protrusio acetabuli (HP:0003179)2.35364202
22Lower limb muscle weakness (HP:0007340)2.32800523
23Hyporeflexia of lower limbs (HP:0002600)2.32784202
24Progressive cerebellar ataxia (HP:0002073)2.31223906
25Atonic seizures (HP:0010819)2.29813274
26Supranuclear gaze palsy (HP:0000605)2.28542366
27Ulnar claw (HP:0001178)2.27496977
28Cutaneous finger syndactyly (HP:0010554)2.26710743
29Buphthalmos (HP:0000557)2.25841625
30Ankle clonus (HP:0011448)2.22436937
31Aortic dissection (HP:0002647)2.22423946
32Coronal craniosynostosis (HP:0004440)2.17972307
33Pheochromocytoma (HP:0002666)2.16427808
34Submucous cleft hard palate (HP:0000176)2.16368597
35Arterial tortuosity (HP:0005116)2.15235598
36Infantile muscular hypotonia (HP:0008947)2.14757637
37Hypoplastic ischia (HP:0003175)2.13431117
38Foot dorsiflexor weakness (HP:0009027)2.12284773
39Steppage gait (HP:0003376)2.07993841
40Cerebral inclusion bodies (HP:0100314)2.07962533
41Morphological abnormality of the middle ear (HP:0008609)2.07905377
42Bradycardia (HP:0001662)2.05454371
43Myokymia (HP:0002411)2.02196585
44Abnormality of the ischium (HP:0003174)2.02118017
45Broad metatarsal (HP:0001783)2.01660449
46Muscle hypertrophy of the lower extremities (HP:0008968)2.01591615
47Wrist flexion contracture (HP:0001239)2.01024813
48Soft skin (HP:0000977)1.99573181
49Lower limb amyotrophy (HP:0007210)1.99128312
50Decreased motor nerve conduction velocity (HP:0003431)1.97969115
51Dysmetria (HP:0001310)1.97505621
52Overgrowth (HP:0001548)1.96584780
53Bell-shaped thorax (HP:0001591)1.96307478
54Cutaneous syndactyly (HP:0012725)1.96173864
55Congenital sensorineural hearing impairment (HP:0008527)1.96063368
56Prolonged QT interval (HP:0001657)1.94719734
57Abnormality of the foot musculature (HP:0001436)1.92806832
58Thickened helices (HP:0000391)1.91365907
59Limb dystonia (HP:0002451)1.90372524
60Fibular aplasia (HP:0002990)1.90144438
61Microglossia (HP:0000171)1.88327020
62Aplasia/Hypoplasia of the lens (HP:0008063)1.88322062
63Spastic gait (HP:0002064)1.87285139
64Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.87082879
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86399866
66Genital tract atresia (HP:0001827)1.85113570
67Vascular tortuosity (HP:0004948)1.85032071
68Hyperventilation (HP:0002883)1.84804111
69Abnormality of incisor morphology (HP:0011063)1.84139580
70Spinal rigidity (HP:0003306)1.83666184
71Adrenal hypoplasia (HP:0000835)1.83569470
72Alacrima (HP:0000522)1.83563436
73Increased variability in muscle fiber diameter (HP:0003557)1.83523019
74Focal seizures (HP:0007359)1.83225059
75Abnormal auditory evoked potentials (HP:0006958)1.81597778
76Bronchomalacia (HP:0002780)1.81578507
77Limited hip movement (HP:0008800)1.81324620
78Abnormality of the calf musculature (HP:0001430)1.80157398
79Vaginal atresia (HP:0000148)1.77853319
80Bladder diverticulum (HP:0000015)1.77535155
81Pulmonary artery stenosis (HP:0004415)1.77485201
82Gait imbalance (HP:0002141)1.77380267
83Abnormality of the nasal septum (HP:0000419)1.77162554
84Aplasia/Hypoplasia of the fibula (HP:0006492)1.76844370
85Slow saccadic eye movements (HP:0000514)1.76417561
86Short 4th metacarpal (HP:0010044)1.75917143
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75917143
88Pterygium (HP:0001059)1.74816099
89Focal motor seizures (HP:0011153)1.74600522
90Aqueductal stenosis (HP:0002410)1.73687415
91Neuroendocrine neoplasm (HP:0100634)1.73229203
92Megalencephaly (HP:0001355)1.72738958
93Cortical dysplasia (HP:0002539)1.71863888
94Peripheral hypomyelination (HP:0007182)1.71606177
95Corneal dystrophy (HP:0001131)1.71581323
96Urinary bladder sphincter dysfunction (HP:0002839)1.70392172
97Stridor (HP:0010307)1.70275491
98Aortic aneurysm (HP:0004942)1.69170707
99Calf muscle hypertrophy (HP:0008981)1.68845713
100Atrophic scars (HP:0001075)1.68818533
101Chin dimple (HP:0010751)1.68545844
102Autoamputation (HP:0001218)1.68491696
103Hypothermia (HP:0002045)1.66988404
104Distal lower limb amyotrophy (HP:0008944)1.66931189
105Wormian bones (HP:0002645)1.66403749
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66041122
107Increased corneal curvature (HP:0100692)1.65687308
108Keratoconus (HP:0000563)1.65687308
109Difficulty running (HP:0009046)1.65503469
110Epileptic encephalopathy (HP:0200134)1.65446855
111Atrial fibrillation (HP:0005110)1.65164224
112Hemiparesis (HP:0001269)1.64948255
113Vertebral arch anomaly (HP:0008438)1.64723842
114Shallow orbits (HP:0000586)1.64620861
115Anteriorly placed anus (HP:0001545)1.64376358
116Bifid tongue (HP:0010297)1.64190405
117Neonatal short-limb short stature (HP:0008921)1.64113968
118Gowers sign (HP:0003391)1.64066679
119EMG: myopathic abnormalities (HP:0003458)1.63975907
120Febrile seizures (HP:0002373)1.63960314
121Specific learning disability (HP:0001328)1.63602473
122Hepatoblastoma (HP:0002884)1.63420173
123Choroideremia (HP:0001139)1.62435764
124Medial flaring of the eyebrow (HP:0010747)1.61742248
125Preaxial foot polydactyly (HP:0001841)1.60381951
126Myelomeningocele (HP:0002475)1.59646212
127Absent frontal sinuses (HP:0002688)1.57424758
128Anterior segment dysgenesis (HP:0007700)1.56956554
129Wide anterior fontanel (HP:0000260)1.56329452
130Drooling (HP:0002307)1.54079812
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.53260013
132Vertebral clefting (HP:0008428)1.53050767
133Bowel diverticulosis (HP:0005222)1.52151769
134Abnormality of the astrocytes (HP:0100707)1.52101339
135Astrocytoma (HP:0009592)1.52101339
136Colon cancer (HP:0003003)1.51149588
137Papillary thyroid carcinoma (HP:0002895)1.50832402
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.49772220
139Glioma (HP:0009733)1.49475990
140Pulmonic stenosis (HP:0001642)1.49325025
141Abnormality of the proximal phalanges of the hand (HP:0009834)1.49050179
142Ankle contracture (HP:0006466)1.48675607
143Myotonia (HP:0002486)1.48073524
144Short tibia (HP:0005736)1.46031910
145Turricephaly (HP:0000262)1.44724420
146Esophageal atresia (HP:0002032)1.43349918
147Optic nerve hypoplasia (HP:0000609)1.43030176
148Chorioretinal atrophy (HP:0000533)1.42892597
149Congenital primary aphakia (HP:0007707)1.42599250
150Fibular hypoplasia (HP:0003038)1.42016984
151Renal hypoplasia (HP:0000089)1.41985959
152Abnormality of the diencephalon (HP:0010662)1.40521668
153Genetic anticipation (HP:0003743)1.39716636
154Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.38444581
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.37188783
156Septo-optic dysplasia (HP:0100842)1.36895904
157Neoplasm of the oral cavity (HP:0100649)1.35565098
158Abnormality of the anterior chamber (HP:0000593)1.34419147
159Synostosis of carpal bones (HP:0005048)1.34114193
160Renal dysplasia (HP:0000110)1.34082521
161Cerebellar dysplasia (HP:0007033)1.33600673
162Anophthalmia (HP:0000528)1.32935227
163Aortic valve stenosis (HP:0001650)1.32660435
164Short nail (HP:0001799)1.31475093
165Fragile skin (HP:0001030)1.31342959
166Stenosis of the external auditory canal (HP:0000402)1.31170108
167Nephrogenic diabetes insipidus (HP:0009806)1.29513091
168Split foot (HP:0001839)1.28606606
169Short hallux (HP:0010109)1.26855757
170Midline defect of the nose (HP:0004122)1.26597061
171Tracheal stenosis (HP:0002777)1.26482157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.97954899
2BCR2.71087713
3OXSR12.67928731
4CASK2.64269957
5TIE12.43299491
6EPHB12.01592350
7MARK11.99730682
8PRPF4B1.86312575
9MAPKAPK51.86280844
10MAPK131.83607196
11WNK11.80577813
12WNK41.80266097
13BMPR1B1.75827093
14PDGFRA1.75525601
15PKN11.75167130
16SGK2231.71850010
17SGK4941.71850010
18LIMK11.59288700
19STK38L1.52443633
20AKT31.50488090
21NTRK31.42858367
22PNCK1.41465932
23PLK21.38852655
24TSSK61.35995765
25PBK1.35885150
26FGFR21.35678560
27EPHB21.32427170
28DDR21.30867717
29CSNK1A1L1.30303388
30MET1.29064891
31NEK61.27365924
32DYRK21.27359795
33PINK11.25835026
34PTK2B1.25160556
35PAK31.23897045
36DMPK1.23728063
37FER1.18996628
38UHMK11.17648356
39PRKCE1.15939743
40PHKG21.15362959
41PHKG11.15362959
42ERBB31.14049538
43MINK11.09597925
44CAMK2B1.08425837
45NTRK11.07220429
46CAMK2D1.06832740
47NEK91.05808142
48PIK3CA1.05734173
49KDR1.02878826
50ROCK21.02791392
51INSRR1.02437956
52FRK1.02348946
53TNIK0.99929849
54MAP4K20.99851560
55CSNK1G20.99589192
56NEK10.98124267
57CAMK2A0.96409676
58CSNK1G30.95867082
59LATS10.94310642
60MARK20.93595093
61LATS20.92924621
62FGR0.92773589
63NUAK10.90841035
64TRPM70.90731318
65CAMK1G0.89711350
66EPHA20.89464466
67MAPK150.88667320
68TRIM280.87948824
69PAK60.87613141
70MAP2K70.87392483
71PRKD30.86896668
72MUSK0.86232512
73SGK20.84830704
74MAP3K40.84599887
75CSNK1G10.80504827
76TGFBR10.79805904
77PRKD10.79089681
78CDK50.78201489
79ROCK10.78162517
80PAK20.75877536
81BMPR20.74434494
82EPHA40.73702566
83NTRK20.73551315
84MAPK120.70243659
85PRKCH0.67972027
86OBSCN0.67656138
87STK380.66534660
88LMTK20.66525229
89GRK70.65333850
90ZAK0.65275477
91CDK140.64463209
92MAP3K90.63639761
93PRKCG0.63613074
94SRPK10.61256232
95RIPK10.58999068
96PRKG10.58882173
97TTK0.58184967
98FGFR10.58036886
99WEE10.56979704
100EPHA30.56509717
101TESK10.56464669
102CAMK2G0.56128438
103GSK3A0.55586158
104PDK20.55064606
105GRK50.54034274
106SGK10.53146321
107KSR10.52743843
108ADRBK10.51956632
109DYRK1A0.51353898
110MKNK20.50764110
111STK30.50257616
112PTK20.50145583
113PLK30.48560989
114YES10.48378554
115MYLK0.48364062
116PDGFRB0.46135933
117MAPK70.45470803
118CDK180.45080801
119CAMK1D0.44833700
120WNK30.44776532
121TTN0.43894218
122GRK10.43375133
123INSR0.43136309
124MOS0.42345337
125MST1R0.42094007
126CSNK1D0.41655841
127PRKCQ0.40153590
128CDK150.39483887
129TGFBR20.39213580
130ERBB40.39013061

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.12632972
2Steroid biosynthesis_Homo sapiens_hsa001002.42310411
3Axon guidance_Homo sapiens_hsa043602.04768319
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95512001
5Fatty acid elongation_Homo sapiens_hsa000621.77750996
6Basal cell carcinoma_Homo sapiens_hsa052171.75399111
7Ether lipid metabolism_Homo sapiens_hsa005651.72062193
8Serotonergic synapse_Homo sapiens_hsa047261.64944036
9Dilated cardiomyopathy_Homo sapiens_hsa054141.54306090
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.51620888
11ECM-receptor interaction_Homo sapiens_hsa045121.51220497
12GABAergic synapse_Homo sapiens_hsa047271.48248198
13Glutamatergic synapse_Homo sapiens_hsa047241.47024347
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44675827
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44139979
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41352314
17Circadian entrainment_Homo sapiens_hsa047131.35584722
18Nicotine addiction_Homo sapiens_hsa050331.33502985
19Morphine addiction_Homo sapiens_hsa050321.32609724
20Renal cell carcinoma_Homo sapiens_hsa052111.27513989
21Vitamin B6 metabolism_Homo sapiens_hsa007501.27023895
22Taste transduction_Homo sapiens_hsa047421.26862782
23Sphingolipid metabolism_Homo sapiens_hsa006001.26854013
24Long-term depression_Homo sapiens_hsa047301.25782163
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24385598
26Cholinergic synapse_Homo sapiens_hsa047251.23786690
27Circadian rhythm_Homo sapiens_hsa047101.22117055
28Dorso-ventral axis formation_Homo sapiens_hsa043201.21711893
29Dopaminergic synapse_Homo sapiens_hsa047281.19505510
30Ras signaling pathway_Homo sapiens_hsa040141.18063028
31Tight junction_Homo sapiens_hsa045301.16734651
32Synaptic vesicle cycle_Homo sapiens_hsa047211.16657444
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.16211709
34Focal adhesion_Homo sapiens_hsa045101.14474204
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14171358
36Rheumatoid arthritis_Homo sapiens_hsa053231.13155710
37Cardiac muscle contraction_Homo sapiens_hsa042601.09645108
38Vibrio cholerae infection_Homo sapiens_hsa051101.09210518
39Cocaine addiction_Homo sapiens_hsa050301.08680359
40Gap junction_Homo sapiens_hsa045401.08061857
41Ovarian steroidogenesis_Homo sapiens_hsa049131.07362405
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07335469
43Oxidative phosphorylation_Homo sapiens_hsa001901.06438034
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04894065
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04781997
46Insulin secretion_Homo sapiens_hsa049111.03808732
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03326746
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02950003
49Phagosome_Homo sapiens_hsa041451.02901738
50Phototransduction_Homo sapiens_hsa047441.00474277
51Renin secretion_Homo sapiens_hsa049240.99823065
52Olfactory transduction_Homo sapiens_hsa047400.99108797
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98762530
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98725018
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98710247
56Propanoate metabolism_Homo sapiens_hsa006400.98171606
57beta-Alanine metabolism_Homo sapiens_hsa004100.97920581
58Rap1 signaling pathway_Homo sapiens_hsa040150.97767076
59Collecting duct acid secretion_Homo sapiens_hsa049660.96157113
60Salivary secretion_Homo sapiens_hsa049700.96149636
61Gastric acid secretion_Homo sapiens_hsa049710.95599560
62Malaria_Homo sapiens_hsa051440.95284321
63Amphetamine addiction_Homo sapiens_hsa050310.94514355
64Butanoate metabolism_Homo sapiens_hsa006500.94433684
65Alzheimers disease_Homo sapiens_hsa050100.94049193
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93786436
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92736104
68Melanogenesis_Homo sapiens_hsa049160.92388843
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.92343901
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92282564
71Oxytocin signaling pathway_Homo sapiens_hsa049210.90495104
72ErbB signaling pathway_Homo sapiens_hsa040120.89640569
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89214598
74GnRH signaling pathway_Homo sapiens_hsa049120.89121998
75Lysine degradation_Homo sapiens_hsa003100.88255445
76cAMP signaling pathway_Homo sapiens_hsa040240.85600179
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85313066
78Long-term potentiation_Homo sapiens_hsa047200.83709559
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83684268
80Adherens junction_Homo sapiens_hsa045200.82596381
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81891562
82Fatty acid metabolism_Homo sapiens_hsa012120.81748733
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81216431
84Hedgehog signaling pathway_Homo sapiens_hsa043400.81143715
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.79897775
86Melanoma_Homo sapiens_hsa052180.78983859
87MAPK signaling pathway_Homo sapiens_hsa040100.77585095
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76790084
89Hippo signaling pathway_Homo sapiens_hsa043900.76319223
90Thyroid hormone synthesis_Homo sapiens_hsa049180.75887036
91Pyruvate metabolism_Homo sapiens_hsa006200.75491202
92Histidine metabolism_Homo sapiens_hsa003400.75477125
93AMPK signaling pathway_Homo sapiens_hsa041520.74948033
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73481043
95Wnt signaling pathway_Homo sapiens_hsa043100.73006440
96Calcium signaling pathway_Homo sapiens_hsa040200.72800633
97Salmonella infection_Homo sapiens_hsa051320.72706943
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72677624
99PPAR signaling pathway_Homo sapiens_hsa033200.72315520
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72131446
101MicroRNAs in cancer_Homo sapiens_hsa052060.71814524
102Parkinsons disease_Homo sapiens_hsa050120.71413093
103Oocyte meiosis_Homo sapiens_hsa041140.71407714
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70996277
105Fatty acid biosynthesis_Homo sapiens_hsa000610.70622133
106TGF-beta signaling pathway_Homo sapiens_hsa043500.70581463
107Endocytosis_Homo sapiens_hsa041440.69405516
108Pancreatic secretion_Homo sapiens_hsa049720.68373159
109Mineral absorption_Homo sapiens_hsa049780.68323325
110African trypanosomiasis_Homo sapiens_hsa051430.68193813
111Protein digestion and absorption_Homo sapiens_hsa049740.67950951
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67585388
113Arginine and proline metabolism_Homo sapiens_hsa003300.66579448
114Nitrogen metabolism_Homo sapiens_hsa009100.66426369
115Protein export_Homo sapiens_hsa030600.65849558
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64526846
117Prostate cancer_Homo sapiens_hsa052150.64336677
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63136719
119Glioma_Homo sapiens_hsa052140.63004707
120Proteoglycans in cancer_Homo sapiens_hsa052050.62790186
121Selenocompound metabolism_Homo sapiens_hsa004500.62734078
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62691543
123Amoebiasis_Homo sapiens_hsa051460.62581712
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62166502
125Pathways in cancer_Homo sapiens_hsa052000.60808632
126Prion diseases_Homo sapiens_hsa050200.60595924
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.59272914
128Choline metabolism in cancer_Homo sapiens_hsa052310.59006216
129Fatty acid degradation_Homo sapiens_hsa000710.58546469
130Estrogen signaling pathway_Homo sapiens_hsa049150.58446386
131Bile secretion_Homo sapiens_hsa049760.58152318
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57914682
133Glucagon signaling pathway_Homo sapiens_hsa049220.53553804
134Small cell lung cancer_Homo sapiens_hsa052220.50846946
135Basal transcription factors_Homo sapiens_hsa030220.49488337
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48752477

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