APBB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of mitochondrion localization (GO:0051654)5.12086447
2pyrimidine nucleobase catabolic process (GO:0006208)4.80011578
3synaptic vesicle maturation (GO:0016188)4.64341133
4synaptic vesicle exocytosis (GO:0016079)4.09462501
5mitochondrion transport along microtubule (GO:0047497)4.02997064
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.02997064
7phosphatidylglycerol biosynthetic process (GO:0006655)3.78343117
8regulation of synaptic vesicle exocytosis (GO:2000300)3.68524621
9postsynaptic membrane organization (GO:0001941)3.61666362
10microtubule nucleation (GO:0007020)3.55613320
11nucleobase catabolic process (GO:0046113)3.53255044
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.40230489
13protein localization to synapse (GO:0035418)3.36239903
14cell migration in hindbrain (GO:0021535)3.36079790
15negative regulation of erythrocyte differentiation (GO:0045647)3.18112821
16negative regulation of cell killing (GO:0031342)3.15642338
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15642338
18protein insertion into membrane (GO:0051205)3.14916934
19regulation of synaptic vesicle transport (GO:1902803)3.08507491
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07831258
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02332142
22glutamate secretion (GO:0014047)3.01695285
23cell-cell junction maintenance (GO:0045217)3.01409256
24neuronal ion channel clustering (GO:0045161)3.00660203
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.00073443
26positive regulation of gamma-delta T cell activation (GO:0046645)2.97007089
27neuronal action potential propagation (GO:0019227)2.95979220
28neuron cell-cell adhesion (GO:0007158)2.91068413
29ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.86991046
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86381988
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85611388
32neurotransmitter secretion (GO:0007269)2.84249889
33locomotory exploration behavior (GO:0035641)2.82249591
34response to peptidoglycan (GO:0032494)2.80802697
35regulation of synapse structural plasticity (GO:0051823)2.78601810
36macrophage activation involved in immune response (GO:0002281)2.76484350
37regulation of vesicle fusion (GO:0031338)2.74933900
38dendritic spine morphogenesis (GO:0060997)2.72270376
39gamma-aminobutyric acid transport (GO:0015812)2.71834546
40exploration behavior (GO:0035640)2.65085639
41positive regulation of synapse maturation (GO:0090129)2.64732861
42positive regulation by symbiont of host defense response (GO:0052509)2.64338760
43modulation by symbiont of host defense response (GO:0052031)2.64338760
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64338760
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64338760
46positive regulation by organism of defense response of other organism involved in symbiotic interact2.64338760
47modulation by symbiont of host immune response (GO:0052553)2.64338760
48neurotransmitter-gated ion channel clustering (GO:0072578)2.63118429
49neuromuscular process controlling posture (GO:0050884)2.62020507
50growth hormone secretion (GO:0030252)2.59002648
51cell junction maintenance (GO:0034331)2.58481107
52axonal fasciculation (GO:0007413)2.58380154
53response to muramyl dipeptide (GO:0032495)2.57414151
54positive regulation of mast cell degranulation (GO:0043306)2.55980475
55positive regulation of mast cell activation involved in immune response (GO:0033008)2.55980475
56respiratory system process (GO:0003016)2.54570782
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54492933
58sulfur amino acid catabolic process (GO:0000098)2.54081502
59histone H4-K12 acetylation (GO:0043983)2.53938504
60energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.53312466
61ATP hydrolysis coupled proton transport (GO:0015991)2.53312466
62mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.51351451
63positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.51351451
64phagosome maturation (GO:0090382)2.50447921
65synaptic transmission, glutamatergic (GO:0035249)2.50410286
66mannose metabolic process (GO:0006013)2.46103484
67auditory behavior (GO:0031223)2.46082254
68cerebellar Purkinje cell differentiation (GO:0021702)2.45748294
69gamma-aminobutyric acid signaling pathway (GO:0007214)2.45120274
70regulation of plasminogen activation (GO:0010755)2.44867197
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.44503978
72regulation of synapse maturation (GO:0090128)2.44348645
73regulation of ARF GTPase activity (GO:0032312)2.44058134
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43721571
75synapse assembly (GO:0007416)2.43312225
76regulation of ARF protein signal transduction (GO:0032012)2.41557900
77positive regulation of mast cell activation (GO:0033005)2.41041810
78germinal center formation (GO:0002467)2.40965615
79neuron recognition (GO:0008038)2.40832239
80activated T cell proliferation (GO:0050798)2.39204307
81neurofilament cytoskeleton organization (GO:0060052)2.35965867
82adaptation of signaling pathway (GO:0023058)2.34845101
83response to parathyroid hormone (GO:0071107)2.34090835
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32823687
85positive regulation of mitochondrial fission (GO:0090141)2.32564009
86regulation of mast cell degranulation (GO:0043304)2.31763343
87vocalization behavior (GO:0071625)2.29837138
88dendritic spine organization (GO:0097061)2.27721066
89regulation of interferon-beta biosynthetic process (GO:0045357)2.26506593
90negative regulation of lymphocyte mediated immunity (GO:0002707)2.25982854
91response to dietary excess (GO:0002021)2.24001786
92axon extension (GO:0048675)2.22844281
93transferrin transport (GO:0033572)2.22842523
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.22548477
95neutrophil activation involved in immune response (GO:0002283)2.22469964
96regulation of beta-amyloid formation (GO:1902003)2.22034131
97neutrophil mediated immunity (GO:0002446)2.21741710
98layer formation in cerebral cortex (GO:0021819)2.20982585
99detection of bacterium (GO:0016045)2.20659333
100behavioral response to nicotine (GO:0035095)2.19621536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48016830
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.18463154
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.16882819
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.81702509
5DROSHA_22980978_ChIP-Seq_HELA_Human2.64223559
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51533127
7LXR_22292898_ChIP-Seq_THP-1_Human2.45048534
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41112139
9* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.41048026
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27468213
11DNAJC2_21179169_ChIP-ChIP_NT2_Human2.23178380
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22623280
13VDR_21846776_ChIP-Seq_THP-1_Human2.20420193
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.18894779
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09239293
16REST_21632747_ChIP-Seq_MESCs_Mouse2.02064843
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.97107799
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91352531
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88445693
20P68_20966046_ChIP-Seq_HELA_Human1.84035089
21EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75057454
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.73649945
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71152481
24KDM2B_26808549_Chip-Seq_K562_Human1.67761671
25KDM2B_26808549_Chip-Seq_DND41_Human1.67043309
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.66189795
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64885341
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61923878
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61694356
30GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59985300
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58793908
32BCL6_27268052_Chip-Seq_Bcells_Human1.58384212
33CTCF_27219007_Chip-Seq_Bcells_Human1.56905477
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.55490835
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.53872097
36SMC4_20622854_ChIP-Seq_HELA_Human1.52164244
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48325457
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48215337
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47976517
40SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45297358
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44913711
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44682633
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43909652
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.43739209
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42808670
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.41710963
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.39970867
48MAF_26560356_Chip-Seq_TH2_Human1.37963856
49BCOR_27268052_Chip-Seq_Bcells_Human1.37643426
50OCT4_19829295_ChIP-Seq_ESCs_Human1.37291210
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35517763
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32999016
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32841556
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29973018
55* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28412187
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27926259
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27837802
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27837802
59PHF8_20622854_ChIP-Seq_HELA_Human1.26829460
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.25935349
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.22417812
62CREB1_26743006_Chip-Seq_LNCaP_Human1.21421709
63TCF7_22412390_ChIP-Seq_EML_Mouse1.21170456
64MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21145494
65E2F1_20622854_ChIP-Seq_HELA_Human1.19543054
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.19180090
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17870764
68SA1_27219007_Chip-Seq_Bcells_Human1.17177765
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16940283
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.16547131
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.16493843
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14251335
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13946902
74UTX_26944678_Chip-Seq_JUKART_Human1.13786677
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12066713
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.11746640
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09760682
78VDR_24763502_ChIP-Seq_THP-1_Human1.05834493
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02750863
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.01984439
81TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01856690
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01508635
83RARB_24833708_ChIP-Seq_LIVER_Mouse1.00781119
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00064073
85* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99603972
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98946133
87CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98897980
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97366189
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96436362
90* TP53_22127205_ChIP-Seq_IMR90_Human0.95787606
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95236238
92CTCF_20526341_ChIP-Seq_ESCs_Human0.94774187
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94740986
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93412436
95MYC_22102868_ChIP-Seq_BL_Human0.93305167
96SPI1_23127762_ChIP-Seq_K562_Human0.93185777
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.92079780
98TP63_22573176_ChIP-Seq_HFKS_Human0.90853757
99ETS1_21867929_ChIP-Seq_TH2_Mouse0.89926692
100OCT4_20526341_ChIP-Seq_ESCs_Human0.89249624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.13826385
2MP0003724_increased_susceptibility_to2.94028190
3MP0003787_abnormal_imprinting2.88762212
4MP0002822_catalepsy2.66792002
5MP0003635_abnormal_synaptic_transmissio2.56400421
6MP0002653_abnormal_ependyma_morphology2.54888249
7MP0005423_abnormal_somatic_nervous2.54218090
8MP0003880_abnormal_central_pattern2.54133984
9MP0006276_abnormal_autonomic_nervous2.47155913
10MP0003172_abnormal_lysosome_physiology2.36489134
11MP0003122_maternal_imprinting2.29127062
12MP0002735_abnormal_chemical_nociception2.26551147
13MP0003303_peritoneal_inflammation2.25299917
14MP0002063_abnormal_learning/memory/cond2.18215530
15MP0001986_abnormal_taste_sensitivity2.00079677
16MP0003436_decreased_susceptibility_to1.99820369
17MP0003879_abnormal_hair_cell1.92812885
18MP0004270_analgesia1.85248579
19MP0002064_seizures1.77525104
20MP0002572_abnormal_emotion/affect_behav1.72902282
21MP0001968_abnormal_touch/_nociception1.71211760
22MP0001486_abnormal_startle_reflex1.70428395
23MP0002733_abnormal_thermal_nociception1.67199603
24MP0009745_abnormal_behavioral_response1.65926064
25MP0002272_abnormal_nervous_system1.59345749
26MP0003183_abnormal_peptide_metabolism1.58424835
27MP0003121_genomic_imprinting1.57346663
28MP0001970_abnormal_pain_threshold1.56496471
29MP0001502_abnormal_circadian_rhythm1.55532299
30MP0001440_abnormal_grooming_behavior1.54380884
31MP0000778_abnormal_nervous_system1.50058114
32MP0005058_abnormal_lysosome_morphology1.45961382
33MP0002734_abnormal_mechanical_nocicepti1.45491972
34MP0004811_abnormal_neuron_physiology1.37810150
35MP0003690_abnormal_glial_cell1.37652135
36MP0003329_amyloid_beta_deposits1.36518251
37MP0009046_muscle_twitch1.35463634
38MP0004130_abnormal_muscle_cell1.33789808
39MP0002419_abnormal_innate_immunity1.32607687
40MP0008995_early_reproductive_senescence1.31455692
41MP0005360_urolithiasis1.29966656
42MP0004142_abnormal_muscle_tone1.28138326
43MP0008569_lethality_at_weaning1.25515867
44MP0008260_abnormal_autophagy1.23203477
45MP0004510_myositis1.21346642
46MP0000013_abnormal_adipose_tissue1.20813347
47MP0000955_abnormal_spinal_cord1.20243499
48MP0005394_taste/olfaction_phenotype1.19696262
49MP0005499_abnormal_olfactory_system1.19696262
50MP0001800_abnormal_humoral_immune1.18744388
51MP0000604_amyloidosis1.16639697
52MP0005025_abnormal_response_to1.15607520
53MP0002882_abnormal_neuron_morphology1.13693349
54MP0005535_abnormal_body_temperature1.13292511
55MP0002557_abnormal_social/conspecific_i1.12305138
56MP0009764_decreased_sensitivity_to1.12276514
57MP0005646_abnormal_pituitary_gland1.11452880
58MP0002067_abnormal_sensory_capabilities1.09813507
59MP0009278_abnormal_bone_marrow1.09509056
60MP0002184_abnormal_innervation1.08023085
61MP0005000_abnormal_immune_tolerance1.06959606
62MP0005387_immune_system_phenotype1.05588624
63MP0001790_abnormal_immune_system1.05588624
64MP0002736_abnormal_nociception_after1.05082236
65MP0002723_abnormal_immune_serum1.04687934
66MP0001501_abnormal_sleep_pattern1.03715112
67MP0002332_abnormal_exercise_endurance1.02097830
68MP0003633_abnormal_nervous_system1.01687948
69MP0008874_decreased_physiological_sensi1.01255006
70MP0001984_abnormal_olfaction1.00616211
71MP0002066_abnormal_motor_capabilities/c0.98957128
72MP0001533_abnormal_skeleton_physiology0.93192348
73MP0002229_neurodegeneration0.92461780
74MP0004043_abnormal_pH_regulation0.91758423
75MP0001529_abnormal_vocalization0.90923489
76MP0002452_abnormal_antigen_presenting0.89900218
77MP0004742_abnormal_vestibular_system0.89426420
78MP0005377_hearing/vestibular/ear_phenot0.86519240
79MP0003878_abnormal_ear_physiology0.86519240
80MP0002420_abnormal_adaptive_immunity0.86021141
81MP0004885_abnormal_endolymph0.85433530
82MP0000026_abnormal_inner_ear0.85270374
83MP0009785_altered_susceptibility_to0.84845655
84MP0001819_abnormal_immune_cell0.84319753
85MP0001963_abnormal_hearing_physiology0.83808211
86MP0005386_behavior/neurological_phenoty0.83635534
87MP0004924_abnormal_behavior0.83635534
88MP0003631_nervous_system_phenotype0.83159249
89MP0005167_abnormal_blood-brain_barrier0.81994027
90MP0005670_abnormal_white_adipose0.81785162
91MP0001905_abnormal_dopamine_level0.81422791
92MP0001188_hyperpigmentation0.80410577
93MP0001764_abnormal_homeostasis0.80262755
94MP0002069_abnormal_eating/drinking_beha0.80118618
95MP0005671_abnormal_response_to0.79768693
96MP0002752_abnormal_somatic_nervous0.75499690
97MP0005551_abnormal_eye_electrophysiolog0.74917615
98MP0001348_abnormal_lacrimal_gland0.74735409
99MP0003123_paternal_imprinting0.74351150
100MP0002152_abnormal_brain_morphology0.68975740

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.77395249
2Myokymia (HP:0002411)3.80783698
3Ankle clonus (HP:0011448)3.75830003
4Mutism (HP:0002300)3.39623957
5Abnormal eating behavior (HP:0100738)3.38910354
6Spontaneous hematomas (HP:0007420)3.36039923
7Papilledema (HP:0001085)3.35175493
8Supranuclear gaze palsy (HP:0000605)3.23072357
9Loss of speech (HP:0002371)3.20534227
10Oligomenorrhea (HP:0000876)3.13676215
11Focal seizures (HP:0007359)3.09620925
12Action tremor (HP:0002345)3.07689444
13Failure to thrive in infancy (HP:0001531)3.02433487
14Focal motor seizures (HP:0011153)2.99967228
15Spastic gait (HP:0002064)2.94173917
16Neuronal loss in central nervous system (HP:0002529)2.92170864
17Epileptic encephalopathy (HP:0200134)2.82734824
18Impaired vibration sensation in the lower limbs (HP:0002166)2.72930696
19Myositis (HP:0100614)2.72210927
20Obstructive sleep apnea (HP:0002870)2.65813664
21Peripheral hypomyelination (HP:0007182)2.64435563
22Agitation (HP:0000713)2.61735172
23Sleep apnea (HP:0010535)2.60099147
24Abnormality of the lower motor neuron (HP:0002366)2.58441039
25Progressive cerebellar ataxia (HP:0002073)2.56607411
26Thoracic kyphosis (HP:0002942)2.50799209
27Spinal canal stenosis (HP:0003416)2.48909599
28Elevated erythrocyte sedimentation rate (HP:0003565)2.47878164
29Recurrent bacterial skin infections (HP:0005406)2.47279604
30Mediastinal lymphadenopathy (HP:0100721)2.47144144
31Recurrent abscess formation (HP:0002722)2.46505760
32Hand muscle atrophy (HP:0009130)2.44551258
33Atonic seizures (HP:0010819)2.44512278
34Eczematoid dermatitis (HP:0000976)2.43138731
35J-shaped sella turcica (HP:0002680)2.40871581
36Rapidly progressive (HP:0003678)2.39967971
37Systemic lupus erythematosus (HP:0002725)2.36461552
38Chronic hepatic failure (HP:0100626)2.36311679
39Amyotrophic lateral sclerosis (HP:0007354)2.31922899
40Dysostosis multiplex (HP:0000943)2.30676032
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29070643
42Abnormality of polysaccharide metabolism (HP:0011012)2.29070643
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29070643
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28927566
45Recurrent gram-negative bacterial infections (HP:0005420)2.28070493
46Long foot (HP:0001833)2.26111172
47Neurofibrillary tangles (HP:0002185)2.25889390
48Febrile seizures (HP:0002373)2.23538024
49Lower limb muscle weakness (HP:0007340)2.18540911
50Hemoptysis (HP:0002105)2.18265975
51Urinary bladder sphincter dysfunction (HP:0002839)2.18079590
52Gait imbalance (HP:0002141)2.17322823
53Visual hallucinations (HP:0002367)2.15617282
54Spastic tetraplegia (HP:0002510)2.14700185
55Clonus (HP:0002169)2.11925123
56Genetic anticipation (HP:0003743)2.10183080
57Increased IgE level (HP:0003212)2.07722858
58Urinary glycosaminoglycan excretion (HP:0003541)2.06524947
59Mucopolysacchariduria (HP:0008155)2.06524947
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02767939
61Retrobulbar optic neuritis (HP:0100654)1.99936137
62Optic neuritis (HP:0100653)1.99936137
63Abnormality of alanine metabolism (HP:0010916)1.99406053
64Hyperalaninemia (HP:0003348)1.99406053
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99406053
66Diminished motivation (HP:0000745)1.97475631
67Cortical visual impairment (HP:0100704)1.96855758
68Abnormality of the corticospinal tract (HP:0002492)1.96656370
69Orchitis (HP:0100796)1.95342431
70Pulmonary embolism (HP:0002204)1.95294737
71Nephrogenic diabetes insipidus (HP:0009806)1.95040958
72Distal upper limb amyotrophy (HP:0007149)1.94626611
73Upper limb amyotrophy (HP:0009129)1.94626611
74Apathy (HP:0000741)1.94394309
75Urinary incontinence (HP:0000020)1.94146563
76Constricted visual fields (HP:0001133)1.92571548
77Cortical dysplasia (HP:0002539)1.90352980
78Visceral angiomatosis (HP:0100761)1.89815033
79Intention tremor (HP:0002080)1.89428176
80Abnormal hair whorl (HP:0010721)1.85941704
81Dyskinesia (HP:0100660)1.85366586
82Intellectual disability, severe (HP:0010864)1.85267407
83Truncal ataxia (HP:0002078)1.83420132
84Excessive salivation (HP:0003781)1.83140609
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82961814
86Hypoplasia of the brainstem (HP:0002365)1.82961814
87Status epilepticus (HP:0002133)1.81217046
88Esotropia (HP:0000565)1.81168494
89Abnormality of binocular vision (HP:0011514)1.80697618
90Diplopia (HP:0000651)1.80697618
91Obstructive lung disease (HP:0006536)1.78166673
92Chronic obstructive pulmonary disease (HP:0006510)1.78166673
93Memory impairment (HP:0002354)1.77395954
94Abnormality of macrophages (HP:0004311)1.77151388
95Hypoplasia of the corpus callosum (HP:0002079)1.76542487
96Urinary urgency (HP:0000012)1.74816572
97Depression (HP:0000716)1.73328312
98Restlessness (HP:0000711)1.72847958
99Specific learning disability (HP:0001328)1.72552788
100Psychosis (HP:0000709)1.72320429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK22.91360310
2MARK12.80281762
3MAP4K12.15336485
4CAMKK12.15252870
5MAP3K112.09130812
6NTRK22.08647094
7RIPK41.94679565
8MARK21.91745401
9TNK21.88175975
10MAP2K31.72525274
11MAPK131.66752038
12NTRK31.63016852
13BLK1.60833865
14ERN11.54556846
15DYRK1B1.54404020
16MAP2K71.46008254
17CAMKK21.43291493
18DAPK21.41658921
19SIK31.33905883
20PAK61.30921839
21MAP2K41.30825075
22IRAK41.29819812
23PRKD21.29126145
24FGR1.27840558
25JAK31.27540477
26SGK4941.25973937
27SGK2231.25973937
28MAP3K61.25639587
29RPS6KA21.24828552
30MAP3K41.23047197
31EPHB11.22765584
32PRPF4B1.22111527
33DYRK21.19099981
34EPHA31.18678260
35UHMK11.17955242
36MAP4K21.15750279
37TYK21.14074313
38TYRO31.11458462
39CASK1.10516675
40SIK11.09349217
41MAPK121.03065040
42FES1.02987531
43TBK11.01717242
44MAP3K31.00878948
45CDK190.98729386
46CDK50.96730240
47PRKD30.95425843
48PIM20.94532798
49TRIB30.94064117
50BCKDK0.90606504
51TAOK10.89735722
52MAP3K70.89411167
53SYK0.89183805
54EPHA40.87788506
55PINK10.87432693
56CAMK10.86979983
57MINK10.82261178
58ZAP700.81575316
59RPS6KC10.76773665
60RPS6KL10.76773665
61TAOK30.75534194
62GRK60.75311487
63ICK0.74835305
64JAK20.74050022
65SGK20.73278789
66IKBKE0.73116672
67PRKCZ0.72022921
68BTK0.71503395
69PKN10.70318932
70DYRK1A0.69773096
71MATK0.69692996
72PRKCH0.69486017
73MAPK150.67815226
74TXK0.67751308
75RPS6KA60.67411185
76KIT0.66829179
77MAP3K130.65679498
78RIPK10.64868849
79SGK30.63564884
80MAPK70.61198236
81HCK0.59667033
82LCK0.59162214
83MARK30.57941396
84STK110.57719374
85FYN0.57151487
86PRKCG0.56799922
87CSK0.56682451
88EPHB20.55929112
89LYN0.55822995
90MAP3K90.53402192
91CAMK40.53107574
92MAPK40.52961154
93PRKD10.50110052
94PAK30.49808657
95MAP3K140.49530590
96CDK90.45149062
97PKN20.44512565
98MAP2K60.43954963
99IRAK20.43567159
100CDC42BPA0.43069346

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.05005455
2Synaptic vesicle cycle_Homo sapiens_hsa047213.03138663
3Nicotine addiction_Homo sapiens_hsa050332.71576889
4Other glycan degradation_Homo sapiens_hsa005112.30513584
5Collecting duct acid secretion_Homo sapiens_hsa049662.28617260
6GABAergic synapse_Homo sapiens_hsa047272.26383744
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20318061
8Morphine addiction_Homo sapiens_hsa050322.20062088
9Glutamatergic synapse_Homo sapiens_hsa047241.67869627
10Osteoclast differentiation_Homo sapiens_hsa043801.62486995
11Cocaine addiction_Homo sapiens_hsa050301.57666506
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.56407491
13Circadian entrainment_Homo sapiens_hsa047131.56273560
14Dopaminergic synapse_Homo sapiens_hsa047281.56118546
15Vibrio cholerae infection_Homo sapiens_hsa051101.47963548
16Cholinergic synapse_Homo sapiens_hsa047251.47908741
17Staphylococcus aureus infection_Homo sapiens_hsa051501.47798686
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41639867
19Phagosome_Homo sapiens_hsa041451.35155527
20Tuberculosis_Homo sapiens_hsa051521.29665290
21Regulation of autophagy_Homo sapiens_hsa041401.28351785
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26315101
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20280322
24Rheumatoid arthritis_Homo sapiens_hsa053231.16857275
25Notch signaling pathway_Homo sapiens_hsa043301.15799159
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13164304
27Leishmaniasis_Homo sapiens_hsa051401.12836387
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11278207
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.10680614
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.10170397
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09070287
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08795697
33Amphetamine addiction_Homo sapiens_hsa050311.07902148
34GnRH signaling pathway_Homo sapiens_hsa049121.06477843
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04764542
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02236454
37Lysosome_Homo sapiens_hsa041421.02202473
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01725129
39Chemokine signaling pathway_Homo sapiens_hsa040621.00621548
40Long-term potentiation_Homo sapiens_hsa047200.98803315
41Axon guidance_Homo sapiens_hsa043600.98507854
42B cell receptor signaling pathway_Homo sapiens_hsa046620.98230878
43Insulin secretion_Homo sapiens_hsa049110.97154724
44Pertussis_Homo sapiens_hsa051330.95214620
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93752651
46Serotonergic synapse_Homo sapiens_hsa047260.90986599
47Taste transduction_Homo sapiens_hsa047420.88666590
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.88316386
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81037591
50Arginine biosynthesis_Homo sapiens_hsa002200.80497502
51Type II diabetes mellitus_Homo sapiens_hsa049300.80204095
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80134882
53Long-term depression_Homo sapiens_hsa047300.79989433
54VEGF signaling pathway_Homo sapiens_hsa043700.79787049
55Endocytosis_Homo sapiens_hsa041440.76734968
56Choline metabolism in cancer_Homo sapiens_hsa052310.75742532
57Oxytocin signaling pathway_Homo sapiens_hsa049210.74898346
58Salmonella infection_Homo sapiens_hsa051320.74834121
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74210393
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73443795
61MAPK signaling pathway_Homo sapiens_hsa040100.73415045
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72836924
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72776984
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72554033
65Type I diabetes mellitus_Homo sapiens_hsa049400.71566300
66Ether lipid metabolism_Homo sapiens_hsa005650.69695865
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69643600
68Ras signaling pathway_Homo sapiens_hsa040140.68781969
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67225735
70Acute myeloid leukemia_Homo sapiens_hsa052210.66827748
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66784350
72Sulfur relay system_Homo sapiens_hsa041220.66598675
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65638650
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65556208
75Gastric acid secretion_Homo sapiens_hsa049710.64074192
76Graft-versus-host disease_Homo sapiens_hsa053320.63436505
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.63395481
78cAMP signaling pathway_Homo sapiens_hsa040240.60908907
79Allograft rejection_Homo sapiens_hsa053300.59536901
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58790974
81Estrogen signaling pathway_Homo sapiens_hsa049150.58465296
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58310502
83TNF signaling pathway_Homo sapiens_hsa046680.56772310
84Prolactin signaling pathway_Homo sapiens_hsa049170.56363912
85Olfactory transduction_Homo sapiens_hsa047400.55793851
86Galactose metabolism_Homo sapiens_hsa000520.54603995
87Prion diseases_Homo sapiens_hsa050200.53148573
88ABC transporters_Homo sapiens_hsa020100.52387357
89AMPK signaling pathway_Homo sapiens_hsa041520.51752095
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51688951
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51614222
92Influenza A_Homo sapiens_hsa051640.51581216
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50439706
94Malaria_Homo sapiens_hsa051440.49005925
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.48976723
96Gap junction_Homo sapiens_hsa045400.46468374
97Asthma_Homo sapiens_hsa053100.45927587
98mTOR signaling pathway_Homo sapiens_hsa041500.44047252
99Autoimmune thyroid disease_Homo sapiens_hsa053200.43536843
100Renin secretion_Homo sapiens_hsa049240.43351716

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »