APC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.10478795
2synaptic vesicle maturation (GO:0016188)5.52944171
3layer formation in cerebral cortex (GO:0021819)5.46527573
4locomotory exploration behavior (GO:0035641)5.37127643
5presynaptic membrane organization (GO:0097090)5.13002715
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01587564
7vocalization behavior (GO:0071625)5.00949447
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94744561
9glutamate secretion (GO:0014047)4.76712717
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69665219
11presynaptic membrane assembly (GO:0097105)4.64801635
12protein localization to synapse (GO:0035418)4.49966241
13synaptic vesicle exocytosis (GO:0016079)4.46909120
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.45866382
15dendritic spine morphogenesis (GO:0060997)4.45059174
16neuron cell-cell adhesion (GO:0007158)4.39387076
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.37484610
18exploration behavior (GO:0035640)4.32071302
19regulation of glutamate receptor signaling pathway (GO:1900449)4.31010871
20dendrite morphogenesis (GO:0048813)4.29767633
21neuronal action potential propagation (GO:0019227)4.28503137
22regulation of synaptic vesicle exocytosis (GO:2000300)4.25824647
23pyrimidine nucleobase catabolic process (GO:0006208)4.19656263
24regulation of synapse structural plasticity (GO:0051823)4.12081999
25synaptic transmission, glutamatergic (GO:0035249)4.04811430
26mechanosensory behavior (GO:0007638)4.03496351
27neurotransmitter-gated ion channel clustering (GO:0072578)3.94488397
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92381171
29neuron recognition (GO:0008038)3.89523522
30proline transport (GO:0015824)3.88589039
31central nervous system projection neuron axonogenesis (GO:0021952)3.87847293
32L-amino acid import (GO:0043092)3.85128275
33C4-dicarboxylate transport (GO:0015740)3.83641062
34glutamate receptor signaling pathway (GO:0007215)3.82082886
35regulation of neuronal synaptic plasticity (GO:0048168)3.80347039
36cell migration in hindbrain (GO:0021535)3.78498115
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74966113
38positive regulation of synapse maturation (GO:0090129)3.72540504
39regulation of synaptic vesicle transport (GO:1902803)3.69961305
40startle response (GO:0001964)3.68369526
41axonal fasciculation (GO:0007413)3.66608595
42neurotransmitter secretion (GO:0007269)3.63465301
43neuron-neuron synaptic transmission (GO:0007270)3.55519912
44gamma-aminobutyric acid transport (GO:0015812)3.49530094
45nucleobase catabolic process (GO:0046113)3.47621832
46postsynaptic membrane organization (GO:0001941)3.45713214
47amino acid import (GO:0043090)3.44058172
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.42839886
49regulation of dendritic spine morphogenesis (GO:0061001)3.38833669
50cellular potassium ion homeostasis (GO:0030007)3.32835547
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28620661
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26670244
53synaptic vesicle endocytosis (GO:0048488)3.24927599
54auditory behavior (GO:0031223)3.23908552
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.21741405
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18855596
57regulation of postsynaptic membrane potential (GO:0060078)3.17448570
58mitochondrion transport along microtubule (GO:0047497)3.16600873
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16600873
60axon extension (GO:0048675)3.16169416
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15672193
62neuromuscular process controlling balance (GO:0050885)3.15657367
63positive regulation of membrane potential (GO:0045838)3.15295684
64long-term memory (GO:0007616)3.14280898
65clathrin coat assembly (GO:0048268)3.13160815
66activation of protein kinase A activity (GO:0034199)3.11484235
67establishment of nucleus localization (GO:0040023)3.11432450
68negative regulation of neurotransmitter transport (GO:0051589)3.10634295
69neurotransmitter uptake (GO:0001504)3.09271709
70sodium ion export (GO:0071436)3.08796879
71establishment of mitochondrion localization (GO:0051654)3.08694845
72organelle transport along microtubule (GO:0072384)3.06358229
73synapse assembly (GO:0007416)3.05220775
74innervation (GO:0060384)3.03900972
75central nervous system neuron axonogenesis (GO:0021955)3.03525407
76response to auditory stimulus (GO:0010996)3.02919259
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02476648
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.01247627
79membrane depolarization during action potential (GO:0086010)2.98865617
80negative regulation of dendrite development (GO:2000171)2.97524759
81cerebellar Purkinje cell differentiation (GO:0021702)2.96763519
82dendritic spine organization (GO:0097061)2.96619697
83vesicle transport along microtubule (GO:0047496)2.93867430
84cerebellar granule cell differentiation (GO:0021707)2.92955118
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92643208
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.92633263
87regulation of neurotransmitter secretion (GO:0046928)2.92161305
88regulation of ARF protein signal transduction (GO:0032012)2.91115776
89central nervous system myelination (GO:0022010)2.91097678
90axon ensheathment in central nervous system (GO:0032291)2.91097678
91regulation of synaptic plasticity (GO:0048167)2.89840259
92positive regulation of synapse assembly (GO:0051965)2.88991414
93acidic amino acid transport (GO:0015800)2.88778817
94synapse organization (GO:0050808)2.87371829
95cell communication by electrical coupling (GO:0010644)2.87276097
96adult walking behavior (GO:0007628)2.87248708
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.86812577
98regulation of synapse maturation (GO:0090128)2.86775939
99regulation of dendritic spine development (GO:0060998)2.86633823
100neurotransmitter transport (GO:0006836)2.86582280
101prepulse inhibition (GO:0060134)2.85971392
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84282990
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82984318
104cerebral cortex radially oriented cell migration (GO:0021799)2.82619526
105nerve growth factor signaling pathway (GO:0038180)2.82053335
106transmission of nerve impulse (GO:0019226)2.81856833
107neuron projection extension (GO:1990138)2.80455327
108positive regulation of dendritic spine development (GO:0060999)2.80188645
109glycosphingolipid biosynthetic process (GO:0006688)2.79558903
110membrane assembly (GO:0071709)2.79058985
111membrane hyperpolarization (GO:0060081)2.78354853
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77994027
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75436840
114behavioral fear response (GO:0001662)2.75290916
115behavioral defense response (GO:0002209)2.75290916
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.75103875
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75063936
118neuronal ion channel clustering (GO:0045161)2.74775079
119cerebral cortex neuron differentiation (GO:0021895)2.73804785
120regulation of neurotransmitter levels (GO:0001505)2.73519266
121regulation of neurotransmitter transport (GO:0051588)2.73133536
122serotonin metabolic process (GO:0042428)2.73089021
123negative regulation of neurotransmitter secretion (GO:0046929)2.72930953
124glycine transport (GO:0015816)2.71081300
125regulation of synapse assembly (GO:0051963)2.69701275
126positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.69615737
127regulation of respiratory system process (GO:0044065)2.67296360
128regulation of cell communication by electrical coupling (GO:0010649)2.65992307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.20679725
2GBX2_23144817_ChIP-Seq_PC3_Human3.45087365
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67419345
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63967929
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61470242
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38327175
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38327175
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37295871
9DROSHA_22980978_ChIP-Seq_HELA_Human2.35786356
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31060345
11REST_21632747_ChIP-Seq_MESCs_Mouse2.28688246
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.22166271
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21910759
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20446650
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17474333
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15908507
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.15380934
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13942901
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12869883
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09222450
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08722114
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.03624090
23AR_21572438_ChIP-Seq_LNCaP_Human1.99720680
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.98201111
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91204714
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91185005
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90460525
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89406686
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.88277944
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81942806
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.73734326
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69616534
33* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67875409
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66728787
35SMAD4_21799915_ChIP-Seq_A2780_Human1.60776759
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52532537
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.52276762
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49637896
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48345984
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47839622
41EWS_26573619_Chip-Seq_HEK293_Human1.46784152
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46237468
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45793379
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45457360
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43659910
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.40209699
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.39430279
48* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39322267
49TAF15_26573619_Chip-Seq_HEK293_Human1.39019457
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38152841
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36374603
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33892509
53* STAT3_23295773_ChIP-Seq_U87_Human1.32632563
54AHR_22903824_ChIP-Seq_MCF-7_Human1.31624169
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31022195
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.30438189
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30435678
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30362598
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.30152691
60* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28831543
61* AR_19668381_ChIP-Seq_PC3_Human1.28476673
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.28254958
63ER_23166858_ChIP-Seq_MCF-7_Human1.28064838
64LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28060139
65* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27547318
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25768562
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.25667307
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24454159
69P300_19829295_ChIP-Seq_ESCs_Human1.24277260
70SOX9_26525672_Chip-Seq_HEART_Mouse1.23669574
71* RUNX2_22187159_ChIP-Seq_PCA_Human1.23542164
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22957202
73KDM2B_26808549_Chip-Seq_K562_Human1.22896297
74ZNF274_21170338_ChIP-Seq_K562_Hela1.22473804
75VDR_22108803_ChIP-Seq_LS180_Human1.22180064
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21870797
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21566725
78BCAT_22108803_ChIP-Seq_LS180_Human1.21454609
79CBP_20019798_ChIP-Seq_JUKART_Human1.21439674
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21439674
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21331681
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20783102
83IGF1R_20145208_ChIP-Seq_DFB_Human1.20405595
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20087832
85AR_25329375_ChIP-Seq_VCAP_Human1.19956351
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19849819
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18751379
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18751379
89JUN_21703547_ChIP-Seq_K562_Human1.18568567
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18283539
91P53_22387025_ChIP-Seq_ESCs_Mouse1.16227595
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16006677
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15889615
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.15806041
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.14950577
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.14909950
97* TCF4_23295773_ChIP-Seq_U87_Human1.14715348
98KDM2B_26808549_Chip-Seq_REH_Human1.14492300
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14379649
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14316210
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12886583
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12886583
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12632247
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.12508236
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11831171
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11732350
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.10869137
108TP53_16413492_ChIP-PET_HCT116_Human1.09873383
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09783522
110* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09426840
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09215794
112* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07642421
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.07323455
114* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07321085
115ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07107710
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06433414
117RNF2_27304074_Chip-Seq_NSC_Mouse1.06296644
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05570167
119FUS_26573619_Chip-Seq_HEK293_Human1.03069467
120* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02069604
121* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01813853
122SMAD3_21741376_ChIP-Seq_ESCs_Human1.01370254
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01192663
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00418993
125CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00272190
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98358430
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96652622
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96433613
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95998468
130DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94797228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.27217797
2MP0004270_analgesia4.16687931
3MP0003635_abnormal_synaptic_transmissio3.87667410
4MP0003880_abnormal_central_pattern3.42714305
5MP0002063_abnormal_learning/memory/cond3.21055560
6MP0005423_abnormal_somatic_nervous3.08656748
7MP0009745_abnormal_behavioral_response2.83849144
8MP0000778_abnormal_nervous_system2.71228143
9MP0002734_abnormal_mechanical_nocicepti2.62014009
10MP0002064_seizures2.58083549
11MP0009780_abnormal_chondrocyte_physiolo2.55756663
12MP0000569_abnormal_digit_pigmentation2.55419042
13MP0001486_abnormal_startle_reflex2.48155624
14MP0002572_abnormal_emotion/affect_behav2.46246230
15MP0009046_muscle_twitch2.40284314
16MP0001968_abnormal_touch/_nociception2.33208385
17MP0004858_abnormal_nervous_system2.10604735
18MP0003787_abnormal_imprinting2.04107621
19MP0002184_abnormal_innervation2.01912192
20MP0004811_abnormal_neuron_physiology1.99974527
21MP0002735_abnormal_chemical_nociception1.99648349
22MP0002272_abnormal_nervous_system1.96196719
23MP0004885_abnormal_endolymph1.95232523
24MP0002733_abnormal_thermal_nociception1.93336995
25MP0001440_abnormal_grooming_behavior1.85982598
26MP0000955_abnormal_spinal_cord1.82446175
27MP0002067_abnormal_sensory_capabilities1.77268181
28MP0002909_abnormal_adrenal_gland1.76469795
29MP0005386_behavior/neurological_phenoty1.74140900
30MP0004924_abnormal_behavior1.74140900
31* MP0002557_abnormal_social/conspecific_i1.73764817
32MP0001970_abnormal_pain_threshold1.68021259
33MP0008569_lethality_at_weaning1.66002460
34MP0003329_amyloid_beta_deposits1.64600695
35MP0002882_abnormal_neuron_morphology1.63279476
36MP0002736_abnormal_nociception_after1.58763744
37MP0001529_abnormal_vocalization1.51287351
38MP0008877_abnormal_DNA_methylation1.49247088
39* MP0002152_abnormal_brain_morphology1.45765250
40MP0002638_abnormal_pupillary_reflex1.43946135
41MP0001501_abnormal_sleep_pattern1.39278087
42MP0001984_abnormal_olfaction1.37785974
43* MP0002066_abnormal_motor_capabilities/c1.35287619
44MP0003879_abnormal_hair_cell1.30786245
45MP0001188_hyperpigmentation1.28791937
46MP0005253_abnormal_eye_physiology1.24617549
47MP0006276_abnormal_autonomic_nervous1.22018265
48MP0003633_abnormal_nervous_system1.21735421
49MP0002822_catalepsy1.19002877
50MP0005646_abnormal_pituitary_gland1.16120625
51MP0001502_abnormal_circadian_rhythm1.15773363
52* MP0003861_abnormal_nervous_system1.14246158
53MP0005645_abnormal_hypothalamus_physiol1.14197342
54MP0002102_abnormal_ear_morphology1.14102877
55MP0005499_abnormal_olfactory_system1.11939469
56MP0005394_taste/olfaction_phenotype1.11939469
57MP0000631_abnormal_neuroendocrine_gland1.11915501
58MP0005551_abnormal_eye_electrophysiolog1.10192908
59MP0003631_nervous_system_phenotype1.08047047
60MP0001177_atelectasis1.06555878
61MP0002751_abnormal_autonomic_nervous1.05491859
62MP0004130_abnormal_muscle_cell1.01075745
63MP0005171_absent_coat_pigmentation0.99379951
64MP0003634_abnormal_glial_cell0.98515610
65MP0001299_abnormal_eye_distance/0.97926351
66MP0002752_abnormal_somatic_nervous0.96551395
67MP0003136_yellow_coat_color0.94585242
68MP0002229_neurodegeneration0.94082046
69MP0003632_abnormal_nervous_system0.93689922
70MP0004742_abnormal_vestibular_system0.90274925
71MP0003122_maternal_imprinting0.89327627
72MP0003890_abnormal_embryonic-extraembry0.89179757
73MP0002069_abnormal_eating/drinking_beha0.88762349
74MP0005174_abnormal_tail_pigmentation0.87976425
75MP0001986_abnormal_taste_sensitivity0.86826778
76MP0005623_abnormal_meninges_morphology0.86730434
77MP0008961_abnormal_basal_metabolism0.85838988
78MP0004043_abnormal_pH_regulation0.84292300
79MP0003283_abnormal_digestive_organ0.82396850
80MP0010234_abnormal_vibrissa_follicle0.81862783
81MP0004085_abnormal_heartbeat0.81146450
82MP0000920_abnormal_myelination0.80289511
83MP0001963_abnormal_hearing_physiology0.77266302
84MP0002234_abnormal_pharynx_morphology0.76260626
85MP0003690_abnormal_glial_cell0.76252699
86MP0003121_genomic_imprinting0.76147953
87MP0000537_abnormal_urethra_morphology0.75398497
88MP0000026_abnormal_inner_ear0.75264260
89MP0002233_abnormal_nose_morphology0.75171585
90MP0004233_abnormal_muscle_weight0.74250550
91MP0000751_myopathy0.73978872
92MP0002653_abnormal_ependyma_morphology0.72582151
93MP0003011_delayed_dark_adaptation0.71490880
94MP0000534_abnormal_ureter_morphology0.71401528
95MP0006072_abnormal_retinal_apoptosis0.70212924
96MP0003137_abnormal_impulse_conducting0.69397518
97* MP0010769_abnormal_survival0.69377074
98* MP0010770_preweaning_lethality0.69066015
99* MP0002082_postnatal_lethality0.69066015
100* MP0002081_perinatal_lethality0.68333762
101MP0005367_renal/urinary_system_phenotyp0.68142925
102MP0000516_abnormal_urinary_system0.68142925
103MP0000427_abnormal_hair_cycle0.67065377
104MP0004215_abnormal_myocardial_fiber0.66616548
105MP0002090_abnormal_vision0.66432534
106MP0001943_abnormal_respiration0.65869708
107MP0005409_darkened_coat_color0.65148214
108MP0008789_abnormal_olfactory_epithelium0.65124493
109* MP0010768_mortality/aging0.64975838
110MP0004145_abnormal_muscle_electrophysio0.64625888
111MP0006292_abnormal_olfactory_placode0.64336524
112MP0001348_abnormal_lacrimal_gland0.63510130
113MP0003755_abnormal_palate_morphology0.63333431
114MP0004142_abnormal_muscle_tone0.62577615
115MP0005195_abnormal_posterior_eye0.61529888
116MP0010386_abnormal_urinary_bladder0.61288499
117* MP0003119_abnormal_digestive_system0.61203738
118MP0001485_abnormal_pinna_reflex0.59769803
119MP0001905_abnormal_dopamine_level0.58450344

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.77954970
2Myokymia (HP:0002411)4.61155625
3Focal seizures (HP:0007359)4.15914193
4Epileptic encephalopathy (HP:0200134)3.62713741
5Visual hallucinations (HP:0002367)3.61759860
6Ankle clonus (HP:0011448)3.56283366
7Progressive cerebellar ataxia (HP:0002073)3.31299881
8Supranuclear gaze palsy (HP:0000605)3.25273087
9Mutism (HP:0002300)3.24219251
10Urinary bladder sphincter dysfunction (HP:0002839)3.17921407
11Excessive salivation (HP:0003781)3.16744331
12Drooling (HP:0002307)3.16744331
13Action tremor (HP:0002345)3.09374093
14Termporal pattern (HP:0011008)3.02659434
15Insidious onset (HP:0003587)3.02659434
16Papilledema (HP:0001085)3.01264856
17Broad-based gait (HP:0002136)3.01104448
18Abnormality of the corticospinal tract (HP:0002492)2.97312582
19Absent speech (HP:0001344)2.95796846
20Genetic anticipation (HP:0003743)2.93850984
21Protruding tongue (HP:0010808)2.84907998
22Febrile seizures (HP:0002373)2.80805608
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.78912442
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78912442
25Inappropriate behavior (HP:0000719)2.74978322
26Megalencephaly (HP:0001355)2.74325683
27Impaired vibration sensation in the lower limbs (HP:0002166)2.73318692
28Urinary urgency (HP:0000012)2.71600456
29Amyotrophic lateral sclerosis (HP:0007354)2.69436974
30Poor eye contact (HP:0000817)2.66749084
31Atonic seizures (HP:0010819)2.52362515
32Absence seizures (HP:0002121)2.51087526
33Spastic gait (HP:0002064)2.49674346
34Generalized tonic-clonic seizures (HP:0002069)2.47979174
35Hypoplasia of the brainstem (HP:0002365)2.46376007
36Aplasia/Hypoplasia of the brainstem (HP:0007362)2.46376007
37Aqueductal stenosis (HP:0002410)2.45452597
38Impaired social interactions (HP:0000735)2.45048729
39Abnormal social behavior (HP:0012433)2.45048729
40Buphthalmos (HP:0000557)2.41174080
41Macroorchidism (HP:0000053)2.40568259
42Hyperventilation (HP:0002883)2.40230274
43Postural instability (HP:0002172)2.40212813
44Dialeptic seizures (HP:0011146)2.37546294
45Gaze-evoked nystagmus (HP:0000640)2.36041089
46Limb dystonia (HP:0002451)2.35895567
47Depression (HP:0000716)2.35665655
48Obstructive sleep apnea (HP:0002870)2.35515161
49Abnormality of the lower motor neuron (HP:0002366)2.35393878
50Cerebral inclusion bodies (HP:0100314)2.34721551
51Inability to walk (HP:0002540)2.33986988
52Truncal ataxia (HP:0002078)2.33982587
53Abnormality of the labia minora (HP:0012880)2.33672073
54Gait imbalance (HP:0002141)2.32526096
55Lower limb muscle weakness (HP:0007340)2.32524207
56Neurofibrillary tangles (HP:0002185)2.31890367
57Dysdiadochokinesis (HP:0002075)2.31445530
58Scanning speech (HP:0002168)2.30477203
59Abnormal eating behavior (HP:0100738)2.28022082
60Tented upper lip vermilion (HP:0010804)2.26664107
61Hemiparesis (HP:0001269)2.24064880
62Decreased lacrimation (HP:0000633)2.23200564
63EEG with generalized epileptiform discharges (HP:0011198)2.22090325
64Blue irides (HP:0000635)2.22036540
65Oligodactyly (hands) (HP:0001180)2.21217691
66Pachygyria (HP:0001302)2.20680466
67Alacrima (HP:0000522)2.20413768
68Epileptiform EEG discharges (HP:0011182)2.19703057
69Hypsarrhythmia (HP:0002521)2.16384157
70Intention tremor (HP:0002080)2.13034602
71Stereotypic behavior (HP:0000733)2.12371045
72Dysmetria (HP:0001310)2.11372237
73Akinesia (HP:0002304)2.11346720
74Torticollis (HP:0000473)2.11292769
75Pheochromocytoma (HP:0002666)2.11180773
76Intellectual disability, profound (HP:0002187)2.10333625
77Abnormality of binocular vision (HP:0011514)2.10064256
78Diplopia (HP:0000651)2.10064256
79Lissencephaly (HP:0001339)2.08435821
80Abnormality of salivation (HP:0100755)2.07790728
81Insomnia (HP:0100785)2.07505449
82Split foot (HP:0001839)2.06803181
83Amblyopia (HP:0000646)2.01681208
84Optic nerve hypoplasia (HP:0000609)2.00278772
85Fetal akinesia sequence (HP:0001989)2.00235807
86Pointed chin (HP:0000307)1.99678934
87Spastic tetraplegia (HP:0002510)1.98310439
88Bradykinesia (HP:0002067)1.98104147
89Open mouth (HP:0000194)1.96116642
90Progressive inability to walk (HP:0002505)1.95343557
91Agitation (HP:0000713)1.95264635
92Impaired smooth pursuit (HP:0007772)1.93485758
93* Papillary thyroid carcinoma (HP:0002895)1.93415288
94Apathy (HP:0000741)1.93074934
95Widely spaced teeth (HP:0000687)1.91784991
96Volvulus (HP:0002580)1.91743007
97Type II lissencephaly (HP:0007260)1.91549477
98Hemiplegia (HP:0002301)1.90135415
99Retinal dysplasia (HP:0007973)1.89020483
100Medial flaring of the eyebrow (HP:0010747)1.88009420
101Retinal atrophy (HP:0001105)1.87403480
102Clonus (HP:0002169)1.86643639
103Polyphagia (HP:0002591)1.85146798
104Specific learning disability (HP:0001328)1.84231312
105Congenital primary aphakia (HP:0007707)1.83897088
106Genital tract atresia (HP:0001827)1.83441720
107Intellectual disability, severe (HP:0010864)1.83214152
108Status epilepticus (HP:0002133)1.82255671
109Elfin facies (HP:0004428)1.80730294
110Exotropia (HP:0000577)1.80678432
111Sacral dimple (HP:0000960)1.80541339
112Anterior segment dysgenesis (HP:0007700)1.80471500
113Gastroesophageal reflux (HP:0002020)1.79653764
114Lower limb amyotrophy (HP:0007210)1.78034628
115Hypoplasia of the corpus callosum (HP:0002079)1.77771639
116Hyperacusis (HP:0010780)1.77684323
117Megalocornea (HP:0000485)1.77089174
118Neuroendocrine neoplasm (HP:0100634)1.75609170
119Vaginal atresia (HP:0000148)1.75244926
120Focal dystonia (HP:0004373)1.75167732
121Impaired vibratory sensation (HP:0002495)1.74795310
122Morphological abnormality of the pyramidal tract (HP:0002062)1.74553360
123Abnormality of ocular smooth pursuit (HP:0000617)1.74486595
124Paraplegia (HP:0010550)1.74484420
125Anxiety (HP:0000739)1.73368839
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.73263774
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70851602
128Intestinal atresia (HP:0011100)1.70710841
129True hermaphroditism (HP:0010459)1.70330412
130Nephrogenic diabetes insipidus (HP:0009806)1.69137128
131Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67387635
132Cutaneous finger syndactyly (HP:0010554)1.67052415
133Muscular hypotonia of the trunk (HP:0008936)1.65949023
134Dyskinesia (HP:0100660)1.64943258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.30063438
2MAP3K93.58063285
3NTRK33.20601236
4EPHA42.69405910
5MAP3K42.65785119
6MINK12.57102213
7NTRK22.42864520
8PAK62.20329081
9BCR2.14641220
10DAPK22.11385002
11LATS21.96846943
12MAP2K71.93276541
13PNCK1.91243834
14KSR11.86801024
15MAPK131.81579520
16ICK1.78368991
17PHKG11.76066237
18PHKG21.76066237
19CAMK1G1.75911005
20PRKD31.65195237
21KSR21.63067377
22CAMKK11.53403820
23CCNB11.53091054
24CASK1.51538562
25CDK51.40356358
26NTRK11.38147196
27SIK21.38048818
28MAP2K41.29492937
29TYRO31.27669344
30DYRK21.25111675
31AKT31.24120365
32ERBB31.24046843
33TRIM281.11585827
34PLK21.08935360
35MARK21.08908383
36MAP3K21.07846290
37TNIK1.06227927
38FGFR21.06083037
39STK381.06023217
40LATS11.04665770
41TAOK11.03950059
42EPHA31.02881236
43RET1.02394772
44BMPR1B1.02392022
45PAK30.96720473
46PRPF4B0.95722784
47UHMK10.92283417
48ALK0.92048950
49PRKCG0.91982195
50RIPK10.91514164
51STK110.90181230
52SGK4940.90112420
53SGK2230.90112420
54MAP4K20.87824858
55DAPK10.86269440
56DYRK1A0.85822478
57SGK30.84701570
58FES0.83684857
59SGK20.83094570
60SCYL20.82802420
61LMTK20.81854182
62CAMK1D0.78288944
63PRKCH0.75044814
64STK390.74993021
65CDK180.73952452
66CDK150.73540335
67CDK140.71404473
68PRKCZ0.71007538
69CAMK10.70858591
70BRD40.70409208
71SGK10.69482547
72STK38L0.69218725
73OXSR10.68616181
74MKNK20.67459027
75PKN10.67080034
76CAMK2A0.65433413
77FER0.63337746
78MAP3K60.61553598
79WNK30.61412257
80CDK11A0.61408703
81* CSNK1G20.60693945
82GRK50.59247675
83NEK60.58735097
84RPS6KA20.55840291
85CAMKK20.55679770
86YES10.54572790
87RPS6KA30.53281792
88PDGFRA0.52417966
89DDR20.52159665
90DMPK0.51539871
91CDC42BPA0.50938957
92FYN0.50033787
93* CSNK1G10.49840793
94EPHB20.49506133
95ACVR1B0.48078301
96FRK0.47591342
97CAMK40.47031161
98NUAK10.46920956
99PRKCE0.46746015
100ROCK20.46665661
101MAPK100.46510601
102WNK10.45415203
103CAMK2D0.45393308
104CAMK2G0.44461180
105PRKAA10.41081455
106RAF10.40440534
107PRKACB0.40345889
108MAPK80.39441661
109* PRKG10.38944135
110PINK10.38937798
111MAPK120.38776751
112MAP3K70.38493711
113CAMK2B0.38451503
114PRKDC0.38088743
115* GSK3B0.37062118
116* PRKACA0.36466959
117* CSNK1D0.36113450
118ROCK10.35639702
119PIK3CA0.35370671
120PDGFRB0.35108592
121LIMK10.34981652
122MAPK90.34516206
123* CSNK1E0.34489273
124ERBB20.33988664
125CDK30.33968713
126FGFR10.32297818
127ERBB40.30199806
128PDK10.30102296
129* CSNK1A1L0.29218244
130MET0.28897630

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.03906063
2Circadian entrainment_Homo sapiens_hsa047132.49446441
3Synaptic vesicle cycle_Homo sapiens_hsa047212.48475430
4Glutamatergic synapse_Homo sapiens_hsa047242.36794773
5GABAergic synapse_Homo sapiens_hsa047272.28789836
6Long-term potentiation_Homo sapiens_hsa047202.22259199
7Olfactory transduction_Homo sapiens_hsa047402.21460879
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17322423
9Morphine addiction_Homo sapiens_hsa050322.05483361
10Amphetamine addiction_Homo sapiens_hsa050311.96162318
11Dopaminergic synapse_Homo sapiens_hsa047281.95388547
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87687668
13Salivary secretion_Homo sapiens_hsa049701.85712178
14Cholinergic synapse_Homo sapiens_hsa047251.84727052
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75119273
16Axon guidance_Homo sapiens_hsa043601.74409687
17Insulin secretion_Homo sapiens_hsa049111.73061852
18Gastric acid secretion_Homo sapiens_hsa049711.61401070
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59173017
20Renin secretion_Homo sapiens_hsa049241.58297190
21Cocaine addiction_Homo sapiens_hsa050301.58292928
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57900557
23Long-term depression_Homo sapiens_hsa047301.54453535
24Gap junction_Homo sapiens_hsa045401.51787536
25Glioma_Homo sapiens_hsa052141.50262092
26Oxytocin signaling pathway_Homo sapiens_hsa049211.49369971
27Dorso-ventral axis formation_Homo sapiens_hsa043201.45146477
28GnRH signaling pathway_Homo sapiens_hsa049121.42945982
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42253515
30ErbB signaling pathway_Homo sapiens_hsa040121.41662623
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38092944
32Estrogen signaling pathway_Homo sapiens_hsa049151.37311287
33Type II diabetes mellitus_Homo sapiens_hsa049301.34152153
34Serotonergic synapse_Homo sapiens_hsa047261.31236222
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29597310
36Taste transduction_Homo sapiens_hsa047421.29463961
37cAMP signaling pathway_Homo sapiens_hsa040241.25880380
38* Endometrial cancer_Homo sapiens_hsa052131.24832086
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23912671
40Calcium signaling pathway_Homo sapiens_hsa040201.16351418
41Butanoate metabolism_Homo sapiens_hsa006501.13411652
42Melanogenesis_Homo sapiens_hsa049161.09204523
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07010996
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05991655
45Phototransduction_Homo sapiens_hsa047441.04050598
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03149986
47Renal cell carcinoma_Homo sapiens_hsa052111.02990353
48Nitrogen metabolism_Homo sapiens_hsa009101.00439568
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.99917949
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97350302
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.97121359
52Choline metabolism in cancer_Homo sapiens_hsa052310.96084727
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95474833
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94397809
55mTOR signaling pathway_Homo sapiens_hsa041500.92454912
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92150929
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89946626
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87497579
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86944483
60Oocyte meiosis_Homo sapiens_hsa041140.85437473
61MAPK signaling pathway_Homo sapiens_hsa040100.85145200
62* Colorectal cancer_Homo sapiens_hsa052100.83678948
63Dilated cardiomyopathy_Homo sapiens_hsa054140.82711514
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.82587757
65Non-small cell lung cancer_Homo sapiens_hsa052230.81994771
66Ras signaling pathway_Homo sapiens_hsa040140.78341176
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75879582
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74530700
69Rap1 signaling pathway_Homo sapiens_hsa040150.74327977
70* Wnt signaling pathway_Homo sapiens_hsa043100.73828045
71Steroid biosynthesis_Homo sapiens_hsa001000.73699334
72VEGF signaling pathway_Homo sapiens_hsa043700.73695512
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73047168
74Collecting duct acid secretion_Homo sapiens_hsa049660.71274702
75Alcoholism_Homo sapiens_hsa050340.69455417
76Vitamin B6 metabolism_Homo sapiens_hsa007500.68364696
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68096160
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67526013
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67342137
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67286462
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.66699452
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66501261
83Insulin signaling pathway_Homo sapiens_hsa049100.66042225
84beta-Alanine metabolism_Homo sapiens_hsa004100.65711013
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65477079
86Thyroid hormone synthesis_Homo sapiens_hsa049180.64247281
87* Hippo signaling pathway_Homo sapiens_hsa043900.62694479
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62604284
89Pancreatic secretion_Homo sapiens_hsa049720.61940450
90Hedgehog signaling pathway_Homo sapiens_hsa043400.60453334
91Propanoate metabolism_Homo sapiens_hsa006400.60244327
92Prolactin signaling pathway_Homo sapiens_hsa049170.58634617
93Endocytosis_Homo sapiens_hsa041440.58233578
94Regulation of autophagy_Homo sapiens_hsa041400.57432440
95Tight junction_Homo sapiens_hsa045300.57046629
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54743810
97Circadian rhythm_Homo sapiens_hsa047100.51502389
98Pancreatic cancer_Homo sapiens_hsa052120.51262292
99Glucagon signaling pathway_Homo sapiens_hsa049220.51038691
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49236394
101Cardiac muscle contraction_Homo sapiens_hsa042600.49069024
102Chronic myeloid leukemia_Homo sapiens_hsa052200.47894748
103Chemokine signaling pathway_Homo sapiens_hsa040620.47060747
104Bile secretion_Homo sapiens_hsa049760.46827637
105Melanoma_Homo sapiens_hsa052180.46170706
106Histidine metabolism_Homo sapiens_hsa003400.45303145
107Fatty acid biosynthesis_Homo sapiens_hsa000610.45013598
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44404676
109* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43706434
110Inositol phosphate metabolism_Homo sapiens_hsa005620.43439022
111Focal adhesion_Homo sapiens_hsa045100.42961009
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42108255
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.42060903
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41837499
115Ovarian steroidogenesis_Homo sapiens_hsa049130.41775597
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41662561
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40616072
118Adherens junction_Homo sapiens_hsa045200.40389116
119Vibrio cholerae infection_Homo sapiens_hsa051100.39550139
120Fatty acid metabolism_Homo sapiens_hsa012120.38159725
121ABC transporters_Homo sapiens_hsa020100.36656870

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