APC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.97756014
2pyrimidine nucleobase catabolic process (GO:0006208)5.68943945
3synaptic vesicle maturation (GO:0016188)5.64430563
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.62937207
5locomotory exploration behavior (GO:0035641)5.59458970
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.29279735
7vocalization behavior (GO:0071625)5.26966019
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.22100765
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11287665
10axon ensheathment in central nervous system (GO:0032291)5.06350440
11central nervous system myelination (GO:0022010)5.06350440
12neuron cell-cell adhesion (GO:0007158)5.04084930
13protein localization to synapse (GO:0035418)4.88097819
14dendritic spine morphogenesis (GO:0060997)4.81581368
15cell migration in hindbrain (GO:0021535)4.74130779
16regulation of glutamate receptor signaling pathway (GO:1900449)4.73878211
17regulation of synapse structural plasticity (GO:0051823)4.65791360
18presynaptic membrane assembly (GO:0097105)4.64670879
19axonal fasciculation (GO:0007413)4.61953049
20exploration behavior (GO:0035640)4.60553786
21synaptic vesicle exocytosis (GO:0016079)4.59866602
22positive regulation of synapse maturation (GO:0090129)4.59664304
23neuron recognition (GO:0008038)4.55299327
24regulation of synaptic vesicle exocytosis (GO:2000300)4.54446516
25nucleobase catabolic process (GO:0046113)4.54230365
26dendrite morphogenesis (GO:0048813)4.50924430
27central nervous system projection neuron axonogenesis (GO:0021952)4.36200583
28glutamate secretion (GO:0014047)4.35587994
29ionotropic glutamate receptor signaling pathway (GO:0035235)4.21914409
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.16702996
31regulation of neuronal synaptic plasticity (GO:0048168)4.12196725
32L-amino acid import (GO:0043092)4.06727792
33response to pheromone (GO:0019236)4.04386338
34neurotransmitter secretion (GO:0007269)3.99617456
35regulation of synaptic vesicle transport (GO:1902803)3.96393261
36postsynaptic membrane organization (GO:0001941)3.94526635
37gamma-aminobutyric acid transport (GO:0015812)3.93598907
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93042707
39neurotransmitter-gated ion channel clustering (GO:0072578)3.84668602
40auditory behavior (GO:0031223)3.83415872
41proline transport (GO:0015824)3.80223527
42synaptic transmission, glutamatergic (GO:0035249)3.77754355
43glutamate receptor signaling pathway (GO:0007215)3.66785014
44cerebellar Purkinje cell differentiation (GO:0021702)3.62993582
45response to auditory stimulus (GO:0010996)3.62239494
46potassium ion import (GO:0010107)3.61060783
47potassium ion homeostasis (GO:0055075)3.57639706
48amino acid import (GO:0043090)3.55905951
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52281019
50regulation of synapse maturation (GO:0090128)3.51668399
51neuromuscular process controlling balance (GO:0050885)3.49632921
52regulation of dendritic spine morphogenesis (GO:0061001)3.48653029
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46532390
54negative regulation of microtubule polymerization (GO:0031115)3.44249406
55neuronal ion channel clustering (GO:0045161)3.41542560
56positive regulation of membrane potential (GO:0045838)3.40992525
57cell communication by electrical coupling (GO:0010644)3.40246324
58neuron-neuron synaptic transmission (GO:0007270)3.39440720
59central nervous system neuron axonogenesis (GO:0021955)3.35317875
60long-term memory (GO:0007616)3.34828221
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34417941
62sodium ion export (GO:0071436)3.33579119
63positive regulation of dendritic spine development (GO:0060999)3.31445116
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.30844905
65cerebellar Purkinje cell layer development (GO:0021680)3.29573928
66regulation of vesicle fusion (GO:0031338)3.28164660
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27167845
68clathrin coat assembly (GO:0048268)3.25976288
69establishment of nucleus localization (GO:0040023)3.25490094
70transmission of nerve impulse (GO:0019226)3.25252964
71neuromuscular synaptic transmission (GO:0007274)3.24677222
72mitochondrion transport along microtubule (GO:0047497)3.24540865
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24540865
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23666140
75adult walking behavior (GO:0007628)3.23266362
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19636224
77activation of protein kinase A activity (GO:0034199)3.19626003
78synaptic vesicle endocytosis (GO:0048488)3.18961748
79cerebellum development (GO:0021549)3.17651492
80presynaptic membrane organization (GO:0097090)3.17395184
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16996456
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16612044
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16121254
84prepulse inhibition (GO:0060134)3.15768841
85cellular potassium ion homeostasis (GO:0030007)3.15656304
86synapse assembly (GO:0007416)3.14508462
87establishment of mitochondrion localization (GO:0051654)3.14429248
88cell differentiation in hindbrain (GO:0021533)3.11043619
89neurotransmitter transport (GO:0006836)3.10803673
90dopamine receptor signaling pathway (GO:0007212)3.10736620
91axon extension (GO:0048675)3.09918117
92regulation of postsynaptic membrane potential (GO:0060078)3.08464876
93negative regulation of axonogenesis (GO:0050771)3.07342687
94cerebellar granule cell differentiation (GO:0021707)3.07187056
95regulation of neurotransmitter transport (GO:0051588)3.06787899
96dendritic spine organization (GO:0097061)3.05080610
97adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.04331999
98regulation of neurotransmitter secretion (GO:0046928)3.03592893
99organelle transport along microtubule (GO:0072384)3.02961222
100regulation of synaptic plasticity (GO:0048167)3.02200053
101behavioral response to nicotine (GO:0035095)3.02084337
102regulation of neurotransmitter levels (GO:0001505)3.01868056
103neuronal action potential propagation (GO:0019227)3.01042950
104axon cargo transport (GO:0008088)3.00451432
105regulation of voltage-gated calcium channel activity (GO:1901385)3.00170073
106regulation of respiratory system process (GO:0044065)2.99870977
107regulation of dendritic spine development (GO:0060998)2.98365277
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95615004
109mechanosensory behavior (GO:0007638)2.94757105
110positive regulation of axon extension (GO:0045773)2.94336844
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93955571
112synapse organization (GO:0050808)2.92068230
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.91937593
114glycine transport (GO:0015816)2.91225283
115positive regulation of synapse assembly (GO:0051965)2.91220186
116innervation (GO:0060384)2.91130170
117nerve growth factor signaling pathway (GO:0038180)2.91104242
118membrane depolarization (GO:0051899)2.90875605
119regulation of axon extension (GO:0030516)2.90275855
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90066547
121membrane hyperpolarization (GO:0060081)2.87150878
122membrane depolarization during action potential (GO:0086010)2.86846943
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85017828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11617859
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03346812
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97505344
4GBX2_23144817_ChIP-Seq_PC3_Human2.85376156
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80889513
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75578037
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75418552
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75418552
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.72644616
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.68862090
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67075325
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66407713
13DROSHA_22980978_ChIP-Seq_HELA_Human2.59053341
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.50573114
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49605383
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.48747089
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44515158
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.42271539
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40680354
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40456664
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39272186
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.38287319
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38177505
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.28922912
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28436768
26* REST_18959480_ChIP-ChIP_MESCs_Mouse2.27438723
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19853538
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06774331
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06661142
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84012229
31AR_21572438_ChIP-Seq_LNCaP_Human1.70571060
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66431066
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63548388
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.60677230
35* RING1B_27294783_Chip-Seq_ESCs_Mouse1.56010374
36ZNF274_21170338_ChIP-Seq_K562_Hela1.54786933
37* KDM2B_26808549_Chip-Seq_K562_Human1.51541715
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49665342
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49294303
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.44761261
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.43709454
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39862381
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39557233
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39086869
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38117489
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36740255
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30808556
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28245734
49SMAD4_21799915_ChIP-Seq_A2780_Human1.24234767
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23770738
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23768309
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22754566
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21425734
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.21318245
55AR_19668381_ChIP-Seq_PC3_Human1.20902313
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19291961
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.16796340
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16314728
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15839330
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15235460
61IGF1R_20145208_ChIP-Seq_DFB_Human1.15104439
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15018878
63RNF2_27304074_Chip-Seq_NSC_Mouse1.14347533
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11548815
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10752636
66LXR_22292898_ChIP-Seq_THP-1_Human1.10541289
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09944959
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08887692
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06759232
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06622371
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06295693
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.06133085
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03193771
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01425690
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99091488
76OCT4_19829295_ChIP-Seq_ESCs_Human0.99015416
77SMAD4_21741376_ChIP-Seq_HESCs_Human0.98825256
78ARNT_22903824_ChIP-Seq_MCF-7_Human0.98106376
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98016619
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97866347
81TAF15_26573619_Chip-Seq_HEK293_Human0.97632092
82AR_25329375_ChIP-Seq_VCAP_Human0.97539715
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97280853
84AHR_22903824_ChIP-Seq_MCF-7_Human0.97213063
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.96875691
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96659336
87* CTCF_27219007_Chip-Seq_Bcells_Human0.96355322
88TET1_21490601_ChIP-Seq_MESCs_Mouse0.96343567
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.95919077
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95866897
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95866897
92STAT3_23295773_ChIP-Seq_U87_Human0.95510511
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95485292
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95425861
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94466902
96* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94037715
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93689945
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93643436
99P300_19829295_ChIP-Seq_ESCs_Human0.93547046
100* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92142120
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91410246
102SMC4_20622854_ChIP-Seq_HELA_Human0.91405587
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91293428
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89913625
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87430716
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87323476
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86071835
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85619355
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85461967
110* KDM2B_26808549_Chip-Seq_JURKAT_Human0.85152264
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84545289
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83819003
113* P68_20966046_ChIP-Seq_HELA_Human0.83302389
114TCF4_23295773_ChIP-Seq_U87_Human0.83127882
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81263380
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.79882078
117* DPY_21335234_ChIP-Seq_ESCs_Mouse0.78400826
118KLF4_19829295_ChIP-Seq_ESCs_Human0.77884708
119RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75868376
120SOX3_22085726_ChIP-Seq_NPCs_Mouse0.75427883
121* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.74483262
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.73423217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.29201657
2MP0003880_abnormal_central_pattern4.14365695
3MP0005423_abnormal_somatic_nervous4.06846255
4MP0004270_analgesia3.93439113
5MP0003635_abnormal_synaptic_transmissio3.87532930
6MP0002063_abnormal_learning/memory/cond3.20947554
7MP0000778_abnormal_nervous_system2.93114128
8MP0009745_abnormal_behavioral_response2.89470659
9MP0002734_abnormal_mechanical_nocicepti2.75969956
10MP0001968_abnormal_touch/_nociception2.71167938
11MP0002064_seizures2.64646270
12MP0009046_muscle_twitch2.60934972
13MP0002572_abnormal_emotion/affect_behav2.48621432
14MP0001486_abnormal_startle_reflex2.40780852
15MP0004858_abnormal_nervous_system2.33014888
16MP0002184_abnormal_innervation2.28366135
17MP0002733_abnormal_thermal_nociception2.22926513
18MP0002735_abnormal_chemical_nociception2.21809828
19MP0004811_abnormal_neuron_physiology2.12330967
20MP0000569_abnormal_digit_pigmentation2.06429784
21MP0006276_abnormal_autonomic_nervous2.05649534
22MP0009780_abnormal_chondrocyte_physiolo2.03845844
23MP0002272_abnormal_nervous_system2.02553263
24MP0003123_paternal_imprinting2.00777930
25MP0000955_abnormal_spinal_cord1.95865076
26MP0001440_abnormal_grooming_behavior1.94383850
27MP0001970_abnormal_pain_threshold1.94136107
28MP0002736_abnormal_nociception_after1.91514582
29MP0002557_abnormal_social/conspecific_i1.90317707
30MP0002067_abnormal_sensory_capabilities1.82882927
31MP0004885_abnormal_endolymph1.81794711
32MP0003329_amyloid_beta_deposits1.81005436
33MP0001984_abnormal_olfaction1.72600389
34MP0008569_lethality_at_weaning1.71244446
35MP0002909_abnormal_adrenal_gland1.70464074
36MP0002882_abnormal_neuron_morphology1.68222411
37MP0004924_abnormal_behavior1.67532650
38MP0005386_behavior/neurological_phenoty1.67532650
39MP0005645_abnormal_hypothalamus_physiol1.65301954
40MP0002822_catalepsy1.64733745
41MP0003787_abnormal_imprinting1.50286441
42MP0001501_abnormal_sleep_pattern1.49127354
43MP0005646_abnormal_pituitary_gland1.47597494
44MP0003136_yellow_coat_color1.45278199
45MP0002152_abnormal_brain_morphology1.45018498
46MP0002066_abnormal_motor_capabilities/c1.41617408
47MP0005499_abnormal_olfactory_system1.28257548
48MP0005394_taste/olfaction_phenotype1.28257548
49MP0003879_abnormal_hair_cell1.22905472
50MP0003122_maternal_imprinting1.22843057
51MP0000631_abnormal_neuroendocrine_gland1.21609943
52MP0001502_abnormal_circadian_rhythm1.19886465
53MP0000920_abnormal_myelination1.17367852
54MP0005187_abnormal_penis_morphology1.14935634
55MP0003861_abnormal_nervous_system1.13721558
56MP0001986_abnormal_taste_sensitivity1.11125212
57MP0009379_abnormal_foot_pigmentation1.07451245
58MP0003633_abnormal_nervous_system1.07335992
59MP0008961_abnormal_basal_metabolism1.04674283
60MP0004142_abnormal_muscle_tone1.02400975
61MP0002653_abnormal_ependyma_morphology1.01905974
62MP0005409_darkened_coat_color1.01743274
63MP0003283_abnormal_digestive_organ1.01614695
64MP0001529_abnormal_vocalization1.00998797
65MP0000537_abnormal_urethra_morphology1.00863176
66MP0002752_abnormal_somatic_nervous0.99324830
67MP0003631_nervous_system_phenotype0.98610429
68MP0002069_abnormal_eating/drinking_beha0.97530322
69MP0004742_abnormal_vestibular_system0.96930694
70MP0004133_heterotaxia0.96626662
71MP0000751_myopathy0.95230801
72MP0003634_abnormal_glial_cell0.95154348
73MP0003137_abnormal_impulse_conducting0.94057280
74MP0004130_abnormal_muscle_cell0.93831099
75MP0001905_abnormal_dopamine_level0.93144267
76MP0001485_abnormal_pinna_reflex0.92861932
77MP0008789_abnormal_olfactory_epithelium0.90070117
78MP0005167_abnormal_blood-brain_barrier0.89964647
79MP0002229_neurodegeneration0.88864383
80MP0001348_abnormal_lacrimal_gland0.82622526
81MP0003632_abnormal_nervous_system0.81270002
82MP0001177_atelectasis0.81194222
83MP0004085_abnormal_heartbeat0.78869465
84MP0004145_abnormal_muscle_electrophysio0.77543574
85MP0001299_abnormal_eye_distance/0.76779014
86MP0000579_abnormal_nail_morphology0.76271028
87MP0000566_synostosis0.75775336
88MP0002638_abnormal_pupillary_reflex0.75214550
89MP0005551_abnormal_eye_electrophysiolog0.74213805
90MP0001963_abnormal_hearing_physiology0.73999343
91MP0000604_amyloidosis0.70757055
92MP0001188_hyperpigmentation0.70578499
93MP0008877_abnormal_DNA_methylation0.69180042
94MP0002751_abnormal_autonomic_nervous0.68480267
95MP0004233_abnormal_muscle_weight0.68023076
96MP0002234_abnormal_pharynx_morphology0.68010761
97MP0005171_absent_coat_pigmentation0.67988131
98MP0002081_perinatal_lethality0.67493464
99MP0005623_abnormal_meninges_morphology0.67262711
100MP0002249_abnormal_larynx_morphology0.67172635
101MP0010769_abnormal_survival0.66423243
102MP0010770_preweaning_lethality0.65158036
103MP0002082_postnatal_lethality0.65158036
104MP0003119_abnormal_digestive_system0.64222390
105MP0000534_abnormal_ureter_morphology0.64180788
106MP0000026_abnormal_inner_ear0.63146580
107MP0001943_abnormal_respiration0.62906158
108MP0003938_abnormal_ear_development0.62621816
109MP0010386_abnormal_urinary_bladder0.62617111
110MP0003690_abnormal_glial_cell0.62568588
111MP0010768_mortality/aging0.62340050
112MP0006292_abnormal_olfactory_placode0.61927842
113MP0002102_abnormal_ear_morphology0.60940812
114MP0003121_genomic_imprinting0.59240450
115MP0005248_abnormal_Harderian_gland0.58955167

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.78267431
2Focal motor seizures (HP:0011153)4.95502683
3Focal seizures (HP:0007359)4.53136679
4Supranuclear gaze palsy (HP:0000605)4.26784188
5Visual hallucinations (HP:0002367)4.24709751
6Mutism (HP:0002300)3.87393875
7Ankle clonus (HP:0011448)3.83300156
8Epileptic encephalopathy (HP:0200134)3.71559723
9Progressive cerebellar ataxia (HP:0002073)3.58798952
10Action tremor (HP:0002345)3.37729509
11Amyotrophic lateral sclerosis (HP:0007354)3.29639324
12Broad-based gait (HP:0002136)3.18984232
13Limb dystonia (HP:0002451)3.13371279
14Insomnia (HP:0100785)3.12331884
15Excessive salivation (HP:0003781)3.08263852
16Drooling (HP:0002307)3.08263852
17Poor eye contact (HP:0000817)3.04492833
18Abnormality of the corticospinal tract (HP:0002492)3.00646425
19Febrile seizures (HP:0002373)2.99898838
20Urinary bladder sphincter dysfunction (HP:0002839)2.98250326
21Genetic anticipation (HP:0003743)2.98091511
22Hemiparesis (HP:0001269)2.96196466
23Megalencephaly (HP:0001355)2.96174781
24Abnormality of the lower motor neuron (HP:0002366)2.95794113
25Abnormal eating behavior (HP:0100738)2.94326307
26Papilledema (HP:0001085)2.91932250
27Polyphagia (HP:0002591)2.83312955
28Urinary urgency (HP:0000012)2.81265334
29Impaired vibration sensation in the lower limbs (HP:0002166)2.79727554
30Depression (HP:0000716)2.78554866
31Peripheral hypomyelination (HP:0007182)2.74555499
32Turricephaly (HP:0000262)2.74404045
33Hyperacusis (HP:0010780)2.73507771
34Abnormal social behavior (HP:0012433)2.73153006
35Impaired social interactions (HP:0000735)2.73153006
36Neurofibrillary tangles (HP:0002185)2.72211911
37Annular pancreas (HP:0001734)2.72059144
38Generalized tonic-clonic seizures (HP:0002069)2.71429143
39Absence seizures (HP:0002121)2.68383525
40Torticollis (HP:0000473)2.66126347
41Spastic gait (HP:0002064)2.65515237
42Elfin facies (HP:0004428)2.61894895
43Insidious onset (HP:0003587)2.61472254
44Termporal pattern (HP:0011008)2.61472254
45Cerebral inclusion bodies (HP:0100314)2.60032260
46Truncal ataxia (HP:0002078)2.55872443
47Atonic seizures (HP:0010819)2.54718937
48Amblyopia (HP:0000646)2.52190801
49Pachygyria (HP:0001302)2.51531737
50Pointed chin (HP:0000307)2.51145264
51Obstructive sleep apnea (HP:0002870)2.48902443
52Progressive inability to walk (HP:0002505)2.46222359
53Anomalous pulmonary venous return (HP:0010772)2.46042282
54Akinesia (HP:0002304)2.42530222
55Inappropriate behavior (HP:0000719)2.42509756
56Dialeptic seizures (HP:0011146)2.42397436
57Apathy (HP:0000741)2.40942575
58Postural instability (HP:0002172)2.39945478
59Rib fusion (HP:0000902)2.37778338
60Lower limb muscle weakness (HP:0007340)2.36813208
61Agitation (HP:0000713)2.35647054
62Overriding aorta (HP:0002623)2.35616912
63Aplasia/Hypoplasia of the brainstem (HP:0007362)2.35349150
64Hypoplasia of the brainstem (HP:0002365)2.35349150
65Focal dystonia (HP:0004373)2.34931237
66Stereotypic behavior (HP:0000733)2.34831444
67Diplopia (HP:0000651)2.34409284
68Abnormality of binocular vision (HP:0011514)2.34409284
69Spastic tetraparesis (HP:0001285)2.33913530
70EEG with generalized epileptiform discharges (HP:0011198)2.33556924
71Hypsarrhythmia (HP:0002521)2.30530231
72Epileptiform EEG discharges (HP:0011182)2.29907220
73Anxiety (HP:0000739)2.29031357
74Dysdiadochokinesis (HP:0002075)2.26578742
75Lissencephaly (HP:0001339)2.24273406
76Fetal akinesia sequence (HP:0001989)2.21944177
77Gaze-evoked nystagmus (HP:0000640)2.21546088
78Dysmetria (HP:0001310)2.16626831
79Aqueductal stenosis (HP:0002410)2.15670159
80Craniofacial dystonia (HP:0012179)2.15333306
81Renovascular hypertension (HP:0100817)2.15137696
82Cerebral hypomyelination (HP:0006808)2.14437639
83Status epilepticus (HP:0002133)2.14274929
84Diminished motivation (HP:0000745)2.13804850
85Hyperventilation (HP:0002883)2.13212916
86Hemiplegia (HP:0002301)2.10899381
87Impaired smooth pursuit (HP:0007772)2.10163941
88Morphological abnormality of the pyramidal tract (HP:0002062)2.09161672
89Intention tremor (HP:0002080)2.09055713
90Oligodactyly (hands) (HP:0001180)2.08477965
91Prolonged QT interval (HP:0001657)2.06913081
92Hepatoblastoma (HP:0002884)2.06794063
93Abnormality of the pulmonary veins (HP:0011718)2.06543495
94Cortical dysplasia (HP:0002539)2.04326277
95Sacral dimple (HP:0000960)2.03247159
96Abnormality of the diencephalon (HP:0010662)2.02269673
97Sleep apnea (HP:0010535)2.00973447
98Bradykinesia (HP:0002067)1.99080870
99Hyperthyroidism (HP:0000836)1.98013645
100Inability to walk (HP:0002540)1.97282400
101Failure to thrive in infancy (HP:0001531)1.97252613
102Degeneration of the lateral corticospinal tracts (HP:0002314)1.94881687
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94881687
104Hypoplasia of the corpus callosum (HP:0002079)1.94724093
105Renal duplication (HP:0000075)1.94582802
106Lower limb amyotrophy (HP:0007210)1.93603522
107Abnormality of salivation (HP:0100755)1.92252693
108Abnormal hair whorl (HP:0010721)1.90608174
109Pheochromocytoma (HP:0002666)1.89874648
110Scanning speech (HP:0002168)1.89774911
111Clonus (HP:0002169)1.89407582
112Spastic tetraplegia (HP:0002510)1.89254011
113Specific learning disability (HP:0001328)1.87929267
114Abnormality of ocular smooth pursuit (HP:0000617)1.87624616
115Flat cornea (HP:0007720)1.86571242
116Myotonia (HP:0002486)1.86408052
117Absent speech (HP:0001344)1.85097402
118Macroorchidism (HP:0000053)1.84054191
119Abnormality of the 4th metacarpal (HP:0010012)1.82507022
120Split foot (HP:0001839)1.82308537
121Gait imbalance (HP:0002141)1.80511460
122Aplasia involving bones of the upper limbs (HP:0009823)1.77457092
123Aplasia of the phalanges of the hand (HP:0009802)1.77457092
124Aplasia involving bones of the extremities (HP:0009825)1.77457092
125Cutaneous finger syndactyly (HP:0010554)1.71928255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.71976370
2MAP3K93.67870486
3NTRK33.25529725
4EPHA42.82493485
5MINK12.71483997
6NTRK22.58726803
7MAP3K42.52614189
8PAK62.40381525
9DAPK22.02850718
10MAP2K72.02755942
11MAPK132.00863840
12KSR11.98471424
13PHKG11.98250309
14PHKG21.98250309
15SIK21.97989184
16DYRK21.73009984
17CAMKK11.71081926
18PRKD31.66655934
19LATS21.55483235
20CDK51.53791752
21RIPK11.52420528
22PINK11.52259936
23NTRK11.50761800
24KSR21.47070978
25ERBB31.46228732
26TYRO31.43097004
27TNIK1.42017138
28TAOK11.38161784
29UHMK11.32036432
30MAP2K41.32001102
31BMPR1B1.31674201
32EPHB21.24835773
33CAMK1D1.21594278
34CSNK1G21.15024151
35PRPF4B1.10160753
36ICK1.03294839
37CASK1.02151714
38MARK20.99990766
39PRKCG0.96486763
40CDK180.95824469
41LIMK10.95072198
42CDK150.94074413
43RET0.91429021
44MUSK0.89983126
45STK110.89953648
46STK380.89674634
47DAPK10.89572630
48CDK140.89452331
49PLK20.87193216
50PAK30.86809140
51DYRK1A0.85163859
52CDK11A0.81818166
53RPS6KA20.81546127
54LMTK20.80159481
55PNCK0.79771889
56ALK0.79656017
57FES0.78795436
58SGK2230.77939630
59SGK4940.77939630
60PRKCZ0.77636571
61GRK50.76845084
62MAP3K120.76535755
63CAMK1G0.76408932
64TNK20.74836666
65CSNK1G30.72375342
66MAPK150.72067591
67CDK190.71656485
68WNK40.70774574
69NEK60.68296349
70MAP3K20.68087225
71DYRK1B0.68065629
72CSNK1A1L0.67952966
73BRAF0.67773733
74PKN10.65710298
75ERBB20.63641952
76PRKCH0.63524888
77FGFR20.63240467
78CAMK2G0.63165154
79CDC42BPA0.59498376
80CAMK2A0.59460973
81CAMKK20.57116828
82WNK10.52828309
83CAMK10.52584628
84FYN0.51934007
85SGK10.50479807
86SGK20.49742858
87ROCK10.48671941
88ROCK20.48429252
89DDR20.47950836
90WNK30.47599855
91ARAF0.47409940
92PDGFRA0.46454257
93BCR0.45702278
94SGK30.45509841
95CAMK2D0.45423244
96MAP3K60.45180905
97MAPK90.44665675
98CCNB10.43799390
99RAF10.43668391
100RPS6KA30.43279699
101CSNK1D0.43209704
102NEK10.43208232
103SCYL20.41529355
104CAMK2B0.40768141
105MAPK100.40564046
106DMPK0.39975243
107TRIB30.39561966
108MAPK80.37464947
109PRKCE0.37148698
110CSNK1G10.36142159
111CAMK40.36011298
112PRKAA10.34291582
113BRSK10.33708515
114CSNK1E0.33450807
115PRKACA0.32774000
116RPS6KB10.32153353
117MAPK120.31674395
118PRKG10.31089870
119MAP3K110.30451105
120RIPK40.29908894
121PRKDC0.29660008

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.24856450
2Synaptic vesicle cycle_Homo sapiens_hsa047212.95316186
3GABAergic synapse_Homo sapiens_hsa047272.64777087
4Circadian entrainment_Homo sapiens_hsa047132.58371017
5Olfactory transduction_Homo sapiens_hsa047402.52938868
6Glutamatergic synapse_Homo sapiens_hsa047242.45651919
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37674335
8Morphine addiction_Homo sapiens_hsa050322.35423490
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18981483
10Dopaminergic synapse_Homo sapiens_hsa047282.18783835
11Long-term potentiation_Homo sapiens_hsa047202.13534366
12Cholinergic synapse_Homo sapiens_hsa047252.03377953
13Axon guidance_Homo sapiens_hsa043602.03059952
14Amphetamine addiction_Homo sapiens_hsa050311.90642032
15Insulin secretion_Homo sapiens_hsa049111.77058949
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75229169
17Salivary secretion_Homo sapiens_hsa049701.72451302
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69926610
19Cocaine addiction_Homo sapiens_hsa050301.65825958
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63924406
21Gastric acid secretion_Homo sapiens_hsa049711.58920353
22Gap junction_Homo sapiens_hsa045401.56907203
23Oxytocin signaling pathway_Homo sapiens_hsa049211.53751671
24Serotonergic synapse_Homo sapiens_hsa047261.50707423
25Taste transduction_Homo sapiens_hsa047421.49988504
26Long-term depression_Homo sapiens_hsa047301.47478219
27Type II diabetes mellitus_Homo sapiens_hsa049301.39546347
28Renin secretion_Homo sapiens_hsa049241.39511279
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35132922
30GnRH signaling pathway_Homo sapiens_hsa049121.34634014
31ErbB signaling pathway_Homo sapiens_hsa040121.28737956
32Glioma_Homo sapiens_hsa052141.28502625
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28129404
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27834829
35Estrogen signaling pathway_Homo sapiens_hsa049151.26327030
36Calcium signaling pathway_Homo sapiens_hsa040201.19053997
37cAMP signaling pathway_Homo sapiens_hsa040241.15821073
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09075232
39Melanogenesis_Homo sapiens_hsa049161.06123368
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.02431577
41* Endometrial cancer_Homo sapiens_hsa052130.97750716
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96080345
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95455450
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.95163658
45Notch signaling pathway_Homo sapiens_hsa043300.95091834
46Oocyte meiosis_Homo sapiens_hsa041140.90886197
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87241889
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85954450
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85935220
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84702940
51VEGF signaling pathway_Homo sapiens_hsa043700.84260558
52Renal cell carcinoma_Homo sapiens_hsa052110.84231505
53Phototransduction_Homo sapiens_hsa047440.83266981
54Choline metabolism in cancer_Homo sapiens_hsa052310.83071493
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82942160
56mTOR signaling pathway_Homo sapiens_hsa041500.82802442
57Dorso-ventral axis formation_Homo sapiens_hsa043200.80520772
58* Colorectal cancer_Homo sapiens_hsa052100.79809621
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79563960
60MAPK signaling pathway_Homo sapiens_hsa040100.78039901
61Alcoholism_Homo sapiens_hsa050340.77399833
62Dilated cardiomyopathy_Homo sapiens_hsa054140.77021007
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76645574
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75825769
65Ras signaling pathway_Homo sapiens_hsa040140.72948614
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.72136832
67Collecting duct acid secretion_Homo sapiens_hsa049660.71787813
68Non-small cell lung cancer_Homo sapiens_hsa052230.71001461
69Cardiac muscle contraction_Homo sapiens_hsa042600.68678901
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67048270
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.66882487
72Rap1 signaling pathway_Homo sapiens_hsa040150.65840772
73Insulin signaling pathway_Homo sapiens_hsa049100.65698633
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65117479
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65112414
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64941165
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64666008
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63514082
79Endocytosis_Homo sapiens_hsa041440.63167716
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62528466
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60991200
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59934813
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58174483
84* Wnt signaling pathway_Homo sapiens_hsa043100.56566520
85Vitamin B6 metabolism_Homo sapiens_hsa007500.55544511
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54086072
87Ovarian steroidogenesis_Homo sapiens_hsa049130.53955990
88Thyroid hormone synthesis_Homo sapiens_hsa049180.52948293
89Nitrogen metabolism_Homo sapiens_hsa009100.52767383
90Hedgehog signaling pathway_Homo sapiens_hsa043400.52194229
91Pancreatic secretion_Homo sapiens_hsa049720.52013924
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51519849
93Inositol phosphate metabolism_Homo sapiens_hsa005620.50151864
94Chemokine signaling pathway_Homo sapiens_hsa040620.46916706
95Prolactin signaling pathway_Homo sapiens_hsa049170.46157749
96Prion diseases_Homo sapiens_hsa050200.46091719
97Vibrio cholerae infection_Homo sapiens_hsa051100.45403371
98Tight junction_Homo sapiens_hsa045300.44431723
99Glucagon signaling pathway_Homo sapiens_hsa049220.43961949
100* Hippo signaling pathway_Homo sapiens_hsa043900.43051043
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.42661734
102Circadian rhythm_Homo sapiens_hsa047100.42400969
103Bile secretion_Homo sapiens_hsa049760.41019803
104Chronic myeloid leukemia_Homo sapiens_hsa052200.40048621
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39001120
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38187691
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37735801
108AMPK signaling pathway_Homo sapiens_hsa041520.37195810
109Alzheimers disease_Homo sapiens_hsa050100.36053647
110beta-Alanine metabolism_Homo sapiens_hsa004100.28334569
111Fatty acid biosynthesis_Homo sapiens_hsa000610.26115497
112* Basal cell carcinoma_Homo sapiens_hsa052170.24670050

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