APCDD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.75514075
2planar cell polarity pathway involved in neural tube closure (GO:0090179)4.71790551
3axon extension involved in axon guidance (GO:0048846)4.64199779
4neuron projection extension involved in neuron projection guidance (GO:1902284)4.64199779
5lateral sprouting from an epithelium (GO:0060601)4.62092878
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.48176410
7negative regulation of catenin import into nucleus (GO:0035414)4.22857751
8cell proliferation involved in metanephros development (GO:0072203)4.16114972
9eye photoreceptor cell differentiation (GO:0001754)3.94749700
10photoreceptor cell differentiation (GO:0046530)3.94749700
11auditory behavior (GO:0031223)3.89424623
12outer ear morphogenesis (GO:0042473)3.89259730
13bone trabecula formation (GO:0060346)3.80833475
14establishment of skin barrier (GO:0061436)3.78765357
15collagen fibril organization (GO:0030199)3.75301332
16keratinization (GO:0031424)3.72199122
17white fat cell differentiation (GO:0050872)3.67656128
18regulation of non-canonical Wnt signaling pathway (GO:2000050)3.64784317
19lung-associated mesenchyme development (GO:0060484)3.64087046
20establishment of tissue polarity (GO:0007164)3.63769605
21establishment of planar polarity (GO:0001736)3.63769605
22dendritic spine morphogenesis (GO:0060997)3.61180139
23G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.60642282
24non-canonical Wnt signaling pathway (GO:0035567)3.55129075
25axon ensheathment in central nervous system (GO:0032291)3.53072586
26central nervous system myelination (GO:0022010)3.53072586
27Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.48072828
28glomerular filtration (GO:0003094)3.46083765
29hippo signaling (GO:0035329)3.41071480
30negative regulation of chondrocyte differentiation (GO:0032331)3.40344984
31regulation of establishment of planar polarity (GO:0090175)3.39078034
32negative regulation of axon extension involved in axon guidance (GO:0048843)3.38125428
33paraxial mesoderm development (GO:0048339)3.36086605
34negative regulation of cartilage development (GO:0061037)3.35828968
35keratinocyte proliferation (GO:0043616)3.32924606
36head development (GO:0060322)3.27034873
37renal filtration (GO:0097205)3.26679927
38hemidesmosome assembly (GO:0031581)3.26189495
39desmosome organization (GO:0002934)3.24223474
40regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.24217052
41lung epithelium development (GO:0060428)3.24197192
42polarized epithelial cell differentiation (GO:0030859)3.22739026
43midbrain development (GO:0030901)3.22389088
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21994167
45branching involved in salivary gland morphogenesis (GO:0060445)3.20312867
46collagen metabolic process (GO:0032963)3.20284613
47anatomical structure regression (GO:0060033)3.19655896
48notochord development (GO:0030903)3.19008470
49dermatan sulfate biosynthetic process (GO:0030208)3.17181784
50establishment of nucleus localization (GO:0040023)3.17001172
51renal system development (GO:0072001)3.16499885
52mesenchymal cell proliferation (GO:0010463)3.16290868
53cell proliferation involved in kidney development (GO:0072111)3.15341931
54mesenchymal-epithelial cell signaling (GO:0060638)3.13789793
55positive regulation of fatty acid beta-oxidation (GO:0032000)3.13444499
56multicellular organismal macromolecule metabolic process (GO:0044259)3.13130354
57negative regulation of axon guidance (GO:1902668)3.12451639
58regulation of water loss via skin (GO:0033561)3.12374786
59positive regulation of gastrulation (GO:2000543)3.12132676
60collagen catabolic process (GO:0030574)3.11586268
61convergent extension (GO:0060026)3.10848794
62negative regulation of inclusion body assembly (GO:0090084)3.10603884
63insulin-like growth factor receptor signaling pathway (GO:0048009)3.04500174
64astrocyte differentiation (GO:0048708)3.02715607
65lymphangiogenesis (GO:0001946)3.02599909
66regulation of axon extension involved in axon guidance (GO:0048841)3.01112748
67regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.00319831
68cochlea morphogenesis (GO:0090103)2.99467653
69dermatan sulfate metabolic process (GO:0030205)2.98694970
70multicellular organismal metabolic process (GO:0044236)2.97159494
71neuronal stem cell maintenance (GO:0097150)2.96141092
72postsynaptic membrane organization (GO:0001941)2.93934253
73regulation of catenin import into nucleus (GO:0035412)2.92903170
74establishment of apical/basal cell polarity (GO:0035089)2.90316012
75low-density lipoprotein particle clearance (GO:0034383)2.89836992
76embryonic skeletal joint morphogenesis (GO:0060272)2.89720961
77hindlimb morphogenesis (GO:0035137)2.89316613
78regulation of axon guidance (GO:1902667)2.88854729
79craniofacial suture morphogenesis (GO:0097094)2.88068155
80epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.87772625
81positive regulation of fatty acid oxidation (GO:0046321)2.87514159
82mesenchyme morphogenesis (GO:0072132)2.87240594
83cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85393796
84multicellular organismal catabolic process (GO:0044243)2.84569950
85radial glial cell differentiation (GO:0060019)2.84167656
86embryonic hindlimb morphogenesis (GO:0035116)2.83439078
87neuron fate determination (GO:0048664)2.81388067
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80941943
89positive regulation of glycogen biosynthetic process (GO:0045725)2.80450827
90negative regulation of embryonic development (GO:0045992)2.78046275
91cell migration involved in heart development (GO:0060973)2.76151496
92smooth muscle tissue development (GO:0048745)2.75609176
93presynaptic membrane assembly (GO:0097105)2.75561604
94limb bud formation (GO:0060174)2.75332685
95Notch signaling involved in heart development (GO:0061314)2.74804769
96mechanosensory behavior (GO:0007638)2.74408928
97proximal/distal pattern formation (GO:0009954)2.74351722
98positive regulation of epithelial to mesenchymal transition (GO:0010718)2.73567542
99extracellular fibril organization (GO:0043206)2.72229468
100positive regulation of macrophage cytokine production (GO:0060907)2.71967612
101response to auditory stimulus (GO:0010996)2.71592444
102mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.71298715
103gastrulation with mouth forming second (GO:0001702)2.70066792
104cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.69185137
105midgut development (GO:0007494)2.68477589
106layer formation in cerebral cortex (GO:0021819)2.67717577
107negative regulation of fatty acid transport (GO:2000192)2.66042975
108endothelial cell chemotaxis (GO:0035767)2.65785811
109stress fiber assembly (GO:0043149)2.64849632
110camera-type eye morphogenesis (GO:0048593)2.64658123
111endodermal cell differentiation (GO:0035987)2.64115550
112negative regulation of oligodendrocyte differentiation (GO:0048715)2.63309286
113basement membrane organization (GO:0071711)2.62894577
114epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61794035
115positive regulation of mesenchymal cell proliferation (GO:0002053)2.61741984
116collecting duct development (GO:0072044)2.60623506
117cardiac muscle cell proliferation (GO:0060038)2.59913281
118dorsal/ventral axis specification (GO:0009950)2.59257484
119extracellular matrix disassembly (GO:0022617)2.58535099
120chondrocyte proliferation (GO:0035988)2.57884712
121regulation of gastrulation (GO:0010470)2.57690388
122embryonic forelimb morphogenesis (GO:0035115)2.57236873
123negative regulation of smooth muscle cell migration (GO:0014912)2.57066535
124positive regulation of glomerulus development (GO:0090193)2.57018814
125negative regulation of leukocyte chemotaxis (GO:0002689)2.56415382
126glomerular basement membrane development (GO:0032836)2.55324391
127regulation of organ formation (GO:0003156)2.54158620
128establishment of monopolar cell polarity (GO:0061162)2.53338304
129establishment or maintenance of monopolar cell polarity (GO:0061339)2.53338304
130embryonic foregut morphogenesis (GO:0048617)2.52900122
131anterior/posterior axis specification, embryo (GO:0008595)2.52228548
132intermediate filament organization (GO:0045109)2.52024503
133regulation of glycogen (starch) synthase activity (GO:2000465)2.51463603
134presynaptic membrane organization (GO:0097090)2.50648003
135endocardial cushion morphogenesis (GO:0003203)2.49889931
136forelimb morphogenesis (GO:0035136)2.48565661
137regulation of cell fate specification (GO:0042659)2.48463492
138regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.46814138
139regulation of cartilage development (GO:0061035)2.46807293
140eyelid development in camera-type eye (GO:0061029)2.46415025
141regulation of somitogenesis (GO:0014807)2.46204117
142otic vesicle formation (GO:0030916)2.44759490
143artery development (GO:0060840)2.41897875
144blood vessel maturation (GO:0001955)2.41555207
145multicellular organismal water homeostasis (GO:0050891)2.41346495
146urogenital system development (GO:0001655)2.41309276
147myelination in peripheral nervous system (GO:0022011)2.40839101
148peripheral nervous system axon ensheathment (GO:0032292)2.40839101
149vasculature development (GO:0001944)2.39937015
150endothelial cell differentiation (GO:0045446)2.38312549
151central nervous system projection neuron axonogenesis (GO:0021952)2.38191865
152vocalization behavior (GO:0071625)2.37351338
153gap junction assembly (GO:0016264)2.35368230
154peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.35340644
155endothelium development (GO:0003158)2.35247162
156positive regulation of embryonic development (GO:0040019)2.35158015
157regulation of inclusion body assembly (GO:0090083)2.34674163
158somite development (GO:0061053)2.33786694
159regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.33434448
160regulation of mesenchymal cell proliferation (GO:0010464)2.33018304
161cell-cell signaling involved in cell fate commitment (GO:0045168)2.32993384
162dopaminergic neuron differentiation (GO:0071542)2.32991288
163regulation of glomerular filtration (GO:0003093)2.32800403
164limb development (GO:0060173)2.32537944
165appendage development (GO:0048736)2.32537944
166negative regulation of vascular permeability (GO:0043116)2.32154174
167heart valve formation (GO:0003188)2.32080391
168retinal ganglion cell axon guidance (GO:0031290)2.31928488
169axonal fasciculation (GO:0007413)2.31337871
170axonemal dynein complex assembly (GO:0070286)2.30785399
171digestive tract morphogenesis (GO:0048546)2.29978313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.39865732
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.67990257
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.30582401
4CLOCK_20551151_ChIP-Seq_293T_Human2.46727848
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42796061
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42796061
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39067032
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.34098256
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.31442508
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.29159438
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09435301
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09087528
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.07343125
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05832601
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05042176
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02567866
17* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95407488
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89370775
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.86359399
20TP53_20018659_ChIP-ChIP_R1E_Mouse1.86202457
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84223527
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83087143
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82424616
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82225963
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81178297
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80494663
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79908187
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78450225
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76195795
30KDM2B_26808549_Chip-Seq_K562_Human1.74877386
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73564279
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.69728816
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.64382625
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64046989
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58837748
36EZH2_22144423_ChIP-Seq_EOC_Human1.57726689
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56307122
38ISL1_27105846_Chip-Seq_CPCs_Mouse1.55594036
39GBX2_23144817_ChIP-Seq_PC3_Human1.53330034
40DROSHA_22980978_ChIP-Seq_HELA_Human1.52995695
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52374440
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50822254
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49919837
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.49250982
45* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48327326
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47884116
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47829938
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.46638761
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.46473447
50RNF2_27304074_Chip-Seq_NSC_Mouse1.46364478
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44987683
52AR_21572438_ChIP-Seq_LNCaP_Human1.44771735
53* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44080621
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.43931178
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43289211
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43271937
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42956030
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.42447076
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42056142
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41403526
61ZNF263_19887448_ChIP-Seq_K562_Human1.40751374
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39011325
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37378321
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34867894
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34867894
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34867894
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.34770099
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32619822
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32556764
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32461688
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28968141
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28641712
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.27461469
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26269816
75KDM2B_26808549_Chip-Seq_DND41_Human1.25678913
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24705798
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.24392152
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24153051
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24031951
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24031951
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23675926
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.22591122
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21483048
84TP53_18474530_ChIP-ChIP_U2OS_Human1.20753323
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20626697
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19839344
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.19704860
88LXR_22292898_ChIP-Seq_THP-1_Human1.19029604
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16604741
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16163676
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15376524
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15375165
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13964037
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12203322
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11741084
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10576168
97AHR_22903824_ChIP-Seq_MCF-7_Human1.10473289
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09950942
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09863085
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09695430
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09237654
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08133265
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06616348
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.06350002
105SMAD4_21799915_ChIP-Seq_A2780_Human1.06084688
106TP53_16413492_ChIP-PET_HCT116_Human1.05805983
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05642639
108RACK7_27058665_Chip-Seq_MCF-7_Human1.05600905
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.05441248
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.05284665
111RXR_22108803_ChIP-Seq_LS180_Human1.05056857
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05009870
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04830022
114* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04391999
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04307227
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03343538
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03201022
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03201022
119TCF4_18268006_ChIP-ChIP_LS174T_Human1.02601152
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02269756
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01915619
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01537175
123CJUN_26792858_Chip-Seq_BT549_Human1.01343221
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01221685
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01010963
126BCAT_22108803_ChIP-Seq_LS180_Human1.00797777
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00794769
128YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00436633
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.98783855
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98539132
131REST_21632747_ChIP-Seq_MESCs_Mouse0.98409077
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97918991
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97203396
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96612189
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.96292606
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95908709
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95368941
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95248909
139BRD4_25478319_ChIP-Seq_HGPS_Human0.94402140
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.93990241
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93956390
142P300_19829295_ChIP-Seq_ESCs_Human0.93724942
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93002985
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.92432036
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90442158
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89931900
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88988361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.44981945
2MP0005275_abnormal_skin_tensile4.64658349
3MP0009379_abnormal_foot_pigmentation4.09924513
4MP0003705_abnormal_hypodermis_morpholog3.59960187
5MP0004272_abnormal_basement_membrane3.11415484
6MP0010030_abnormal_orbit_morphology2.76574775
7MP0005503_abnormal_tendon_morphology2.71921435
8MP0009053_abnormal_anal_canal2.61833185
9MP0003283_abnormal_digestive_organ2.42888222
10MP0003136_yellow_coat_color2.38395207
11MP0000537_abnormal_urethra_morphology2.36339074
12MP0005670_abnormal_white_adipose2.24131770
13MP0004885_abnormal_endolymph2.13914579
14MP0005409_darkened_coat_color2.10393120
15MP0000579_abnormal_nail_morphology2.09037111
16MP0001879_abnormal_lymphatic_vessel1.94225244
17MP0010234_abnormal_vibrissa_follicle1.91512395
18MP0005171_absent_coat_pigmentation1.86064295
19MP0002060_abnormal_skin_morphology1.84792097
20MP0004185_abnormal_adipocyte_glucose1.83390588
21MP0003122_maternal_imprinting1.79249762
22MP0005666_abnormal_adipose_tissue1.77391690
23MP0003942_abnormal_urinary_system1.75693453
24MP0002249_abnormal_larynx_morphology1.74805552
25MP0005623_abnormal_meninges_morphology1.73577778
26MP0000534_abnormal_ureter_morphology1.71453602
27MP0003385_abnormal_body_wall1.69309380
28MP0005248_abnormal_Harderian_gland1.64483635
29MP0002234_abnormal_pharynx_morphology1.60566079
30MP0005375_adipose_tissue_phenotype1.60474992
31MP0009250_abnormal_appendicular_skeleto1.58885888
32MP0001958_emphysema1.58645977
33MP0000566_synostosis1.57274956
34MP0006054_spinal_hemorrhage1.54273806
35MP0000762_abnormal_tongue_morphology1.53933026
36MP0002282_abnormal_trachea_morphology1.51234243
37MP0000428_abnormal_craniofacial_morphol1.50998581
38MP0005076_abnormal_cell_differentiation1.50909034
39MP0001849_ear_inflammation1.50464199
40MP0000733_abnormal_muscle_development1.50264118
41MP0002932_abnormal_joint_morphology1.47474887
42MP0000049_abnormal_middle_ear1.47033013
43MP0005508_abnormal_skeleton_morphology1.46498069
44MP0000003_abnormal_adipose_tissue1.46483980
45MP0009780_abnormal_chondrocyte_physiolo1.46222950
46MP0001984_abnormal_olfaction1.44276505
47MP0004130_abnormal_muscle_cell1.42330597
48MP0000467_abnormal_esophagus_morphology1.41578006
49MP0010368_abnormal_lymphatic_system1.38256143
50MP0002796_impaired_skin_barrier1.38205140
51MP0003115_abnormal_respiratory_system1.37718456
52MP0002108_abnormal_muscle_morphology1.37634432
53MP0002638_abnormal_pupillary_reflex1.35970282
54MP0010678_abnormal_skin_adnexa1.32197462
55MP0001299_abnormal_eye_distance/1.29297960
56MP0000013_abnormal_adipose_tissue1.28934149
57MP0000383_abnormal_hair_follicle1.27563288
58MP0009384_cardiac_valve_regurgitation1.25981158
59MP0002116_abnormal_craniofacial_bone1.20765763
60MP0000751_myopathy1.19376065
61MP0001243_abnormal_dermal_layer1.19303217
62MP0005187_abnormal_penis_morphology1.18799077
63MP0003755_abnormal_palate_morphology1.17516305
64MP0003935_abnormal_craniofacial_develop1.15777362
65MP0000462_abnormal_digestive_system1.15576101
66MP0003941_abnormal_skin_development1.15528948
67MP0004858_abnormal_nervous_system1.15524093
68MP0003937_abnormal_limbs/digits/tail_de1.15495092
69MP0001188_hyperpigmentation1.15132177
70MP0000647_abnormal_sebaceous_gland1.14394157
71MP0003011_delayed_dark_adaptation1.11262819
72MP0002896_abnormal_bone_mineralization1.09890077
73MP0000163_abnormal_cartilage_morphology1.09563113
74MP0005595_abnormal_vascular_smooth1.08647920
75MP0003938_abnormal_ear_development1.07925448
76MP0003119_abnormal_digestive_system1.07728282
77MP0000026_abnormal_inner_ear1.06954800
78MP0002233_abnormal_nose_morphology1.06787572
79MP0002098_abnormal_vibrissa_morphology1.05318865
80MP0002653_abnormal_ependyma_morphology1.03257832
81MP0008789_abnormal_olfactory_epithelium1.03170978
82MP0002089_abnormal_postnatal_growth/wei1.02340422
83MP0001293_anophthalmia1.02167862
84MP0003566_abnormal_cell_adhesion1.01605479
85MP0002938_white_spotting1.01375155
86MP0001486_abnormal_startle_reflex1.00699160
87MP0002095_abnormal_skin_pigmentation0.99587228
88MP0002115_abnormal_skeleton_extremities0.98759868
89MP0009115_abnormal_fat_cell0.98738415
90MP0003123_paternal_imprinting0.97917294
91MP0002111_abnormal_tail_morphology0.97066342
92MP0000432_abnormal_head_morphology0.97046531
93MP0005394_taste/olfaction_phenotype0.96189409
94MP0005499_abnormal_olfactory_system0.96189409
95MP0005257_abnormal_intraocular_pressure0.96013806
96MP0002295_abnormal_pulmonary_circulatio0.95798058
97MP0003880_abnormal_central_pattern0.95245629
98MP0002254_reproductive_system_inflammat0.92653802
99MP0004859_abnormal_synaptic_plasticity0.91854534
100MP0003279_aneurysm0.91213365
101MP0002109_abnormal_limb_morphology0.88672705
102MP0010771_integument_phenotype0.87397295
103MP0002092_abnormal_eye_morphology0.87308405
104MP0004197_abnormal_fetal_growth/weight/0.82555067
105MP0008961_abnormal_basal_metabolism0.82521780
106MP0000516_abnormal_urinary_system0.81794536
107MP0005367_renal/urinary_system_phenotyp0.81794536
108MP0010352_gastrointestinal_tract_polyps0.81022238
109MP0004381_abnormal_hair_follicle0.80777628
110MP0005501_abnormal_skin_physiology0.79908842
111MP0004134_abnormal_chest_morphology0.79664361
112MP0000377_abnormal_hair_follicle0.79333799
113MP0005167_abnormal_blood-brain_barrier0.79056872
114MP0002697_abnormal_eye_size0.77173797
115MP0000767_abnormal_smooth_muscle0.76948842
116MP0000778_abnormal_nervous_system0.76352148
117MP0001340_abnormal_eyelid_morphology0.75582227
118MP0003453_abnormal_keratinocyte_physiol0.74974921
119MP0002114_abnormal_axial_skeleton0.74392263
120MP0001485_abnormal_pinna_reflex0.74363332
121MP0002925_abnormal_cardiovascular_devel0.71682516
122MP0002009_preneoplasia0.71111570
123MP0004233_abnormal_muscle_weight0.70914246
124MP0006138_congestive_heart_failure0.70739886
125MP0001216_abnormal_epidermal_layer0.70656679
126MP0002735_abnormal_chemical_nociception0.70609097
127MP0003878_abnormal_ear_physiology0.70479301
128MP0005377_hearing/vestibular/ear_phenot0.70479301
129MP0002113_abnormal_skeleton_development0.70044013
130MP0000955_abnormal_spinal_cord0.70031252
131MP0001286_abnormal_eye_development0.68908490
132MP0004142_abnormal_muscle_tone0.68716325
133MP0002557_abnormal_social/conspecific_i0.66369062
134MP0002572_abnormal_emotion/affect_behav0.65640218
135MP0002063_abnormal_learning/memory/cond0.64911906
136MP0005423_abnormal_somatic_nervous0.64732841
137MP0000631_abnormal_neuroendocrine_gland0.64390871
138MP0002837_dystrophic_cardiac_calcinosis0.63854946

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)4.50333191
2Shallow orbits (HP:0000586)4.49436208
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.17498591
4Short 4th metacarpal (HP:0010044)4.17498591
5Premature rupture of membranes (HP:0001788)4.06145901
6Follicular hyperkeratosis (HP:0007502)4.01484806
7Protrusio acetabuli (HP:0003179)3.99395740
8Atrophic scars (HP:0001075)3.81782981
9Broad metatarsal (HP:0001783)3.80914852
10Abnormality of the 4th metacarpal (HP:0010012)3.76971296
11Abnormality of secondary sexual hair (HP:0009888)3.68587956
12Abnormality of the axillary hair (HP:0100134)3.68587956
13Type 1 muscle fiber predominance (HP:0003803)3.54871968
14Renal duplication (HP:0000075)3.49326529
15Split foot (HP:0001839)3.40213018
16Bladder diverticulum (HP:0000015)3.28144627
17Cerebral aneurysm (HP:0004944)3.25330842
18* Hypotrichosis (HP:0001006)3.22022303
19Fragile skin (HP:0001030)3.19249245
20Slender build (HP:0001533)3.11171289
21Milia (HP:0001056)3.08215494
22Abnormality of the parietal bone (HP:0002696)3.08017171
23Aortic dissection (HP:0002647)3.07882385
24Increased connective tissue (HP:0009025)3.03668284
25Absent eyelashes (HP:0000561)2.94236759
26Soft skin (HP:0000977)2.81074600
27Mitral valve prolapse (HP:0001634)2.77954836
28Turricephaly (HP:0000262)2.76842035
29Increased variability in muscle fiber diameter (HP:0003557)2.76321054
30Coronal craniosynostosis (HP:0004440)2.70865674
31Renovascular hypertension (HP:0100817)2.67664931
32Spinal rigidity (HP:0003306)2.67137359
33Neoplasm of the heart (HP:0100544)2.66599002
34Deviation of the hallux (HP:0010051)2.64945139
35Dilatation of the ascending aorta (HP:0005111)2.59506797
36Mildly elevated creatine phosphokinase (HP:0008180)2.56179968
37Hallux valgus (HP:0001822)2.49426807
38Hyperacusis (HP:0010780)2.46571270
39Absent hair (HP:0002298)2.42530072
40Abnormality of molar morphology (HP:0011070)2.37466053
41Abnormality of molar (HP:0011077)2.37466053
42Mesomelia (HP:0003027)2.35441724
43Bowel diverticulosis (HP:0005222)2.33642179
44Abnormality of skeletal muscle fiber size (HP:0012084)2.32560821
45Cutaneous syndactyly (HP:0012725)2.31036811
46Vascular tortuosity (HP:0004948)2.30854421
47Buphthalmos (HP:0000557)2.26954760
48Erythroderma (HP:0001019)2.24002662
49Cutaneous finger syndactyly (HP:0010554)2.23876129
50Broad toe (HP:0001837)2.23594301
51Elfin facies (HP:0004428)2.23489927
52Abnormality of the dental root (HP:0006486)2.22908273
53Taurodontia (HP:0000679)2.22908273
54Abnormality of permanent molar morphology (HP:0011071)2.22908273
55Ankyloglossia (HP:0010296)2.19065388
56Fragile nails (HP:0001808)2.18574290
57Flat cornea (HP:0007720)2.17845879
58Abnormality of nail color (HP:0100643)2.15353033
59Pulmonary artery stenosis (HP:0004415)2.14703808
60Hyperextensible skin (HP:0000974)2.14669611
61Partial duplication of thumb phalanx (HP:0009944)2.14667880
62Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.13338300
63Lymphangioma (HP:0100764)2.12818406
64Overriding aorta (HP:0002623)2.12249824
65Limited hip movement (HP:0008800)2.12201266
66Palmoplantar hyperkeratosis (HP:0000972)2.10208756
67Striae distensae (HP:0001065)2.09737150
68Abnormality of the diencephalon (HP:0010662)2.09433318
69Down-sloping shoulders (HP:0200021)2.08547294
70Acanthosis nigricans (HP:0000956)2.07885937
71Abnormality of the ischium (HP:0003174)2.05880815
72Joint laxity (HP:0001388)2.05021619
73Abnormality of the labia majora (HP:0012881)2.04387550
74Neonatal short-limb short stature (HP:0008921)2.04148537
75Short phalanx of the thumb (HP:0009660)2.02951704
76Aortic aneurysm (HP:0004942)2.02858082
77Partial duplication of the phalanx of hand (HP:0009999)2.00796826
78Palmar hyperkeratosis (HP:0010765)2.00728376
79Abnormality of the dental pulp (HP:0006479)2.00668057
80Supernumerary ribs (HP:0005815)1.99495386
81Blue sclerae (HP:0000592)1.98595655
82Venous insufficiency (HP:0005293)1.98034365
83Narrow nasal bridge (HP:0000446)1.97420641
84* Woolly hair (HP:0002224)1.97288325
85Concave nail (HP:0001598)1.97030202
86Peritonitis (HP:0002586)1.95676309
87Short hallux (HP:0010109)1.95124012
88Aplasia involving bones of the upper limbs (HP:0009823)1.94584864
89Aplasia of the phalanges of the hand (HP:0009802)1.94584864
90Aplasia involving bones of the extremities (HP:0009825)1.94584864
91Hypoventilation (HP:0002791)1.94409688
92Protruding ear (HP:0000411)1.92193358
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.91853818
94Venous abnormality (HP:0002624)1.91390768
95Increased IgE level (HP:0003212)1.91359538
96Tracheomalacia (HP:0002779)1.90907335
97Absent hand (HP:0004050)1.89807257
98Narrow palate (HP:0000189)1.89485913
99Wide anterior fontanel (HP:0000260)1.89445577
100Abnormality of the aortic arch (HP:0012303)1.88932928
101Genu recurvatum (HP:0002816)1.88851503
102Hypoplastic ischia (HP:0003175)1.88202680
103Plantar hyperkeratosis (HP:0007556)1.88040393
104Trigonocephaly (HP:0000243)1.87718961
105Enlarged penis (HP:0000040)1.87475760
106Bronchomalacia (HP:0002780)1.86802998
107Laryngomalacia (HP:0001601)1.86095649
108Arnold-Chiari malformation (HP:0002308)1.85578283
109Rectal prolapse (HP:0002035)1.85262594
110Wrist flexion contracture (HP:0001239)1.84425038
111Exostoses (HP:0100777)1.84106567
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83995178
113Broad thumb (HP:0011304)1.83914760
114Mixed hearing impairment (HP:0000410)1.83730718
115Abnormal respiratory motile cilium morphology (HP:0005938)1.83586411
116Abnormal respiratory epithelium morphology (HP:0012253)1.83586411
117Abnormal ciliary motility (HP:0012262)1.82981653
118Ridged nail (HP:0001807)1.82813754
119Alopecia of scalp (HP:0002293)1.81426252
120Hepatoblastoma (HP:0002884)1.80935084
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79234583
122Osteoarthritis (HP:0002758)1.79197324
123Broad hallux (HP:0010055)1.78685444
124Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76951838
125Insomnia (HP:0100785)1.75320670
126Bilateral microphthalmos (HP:0007633)1.74736609
127Sparse scalp hair (HP:0002209)1.74253563
128Aplasia/Hypoplasia of the hallux (HP:0008362)1.73261717
129Obstructive sleep apnea (HP:0002870)1.72385387
130Oligodactyly (hands) (HP:0001180)1.71469825
131Abnormality of oral frenula (HP:0000190)1.71091141
132Anophthalmia (HP:0000528)1.70762048
133Hypoplastic labia majora (HP:0000059)1.70472160
134Broad long bones (HP:0005622)1.70010491
135Maternal diabetes (HP:0009800)1.69509419
136Abnormal respiratory motile cilium physiology (HP:0012261)1.69305188
137Renal dysplasia (HP:0000110)1.67660962
138Onycholysis (HP:0001806)1.67415150
139Midline defect of the nose (HP:0004122)1.67302967
140Long nose (HP:0003189)1.67187906
141Oligodontia (HP:0000677)1.67152474
142Limb-girdle muscle weakness (HP:0003325)1.66816363
143Nasolacrimal duct obstruction (HP:0000579)1.66531195
144Supernumerary bones of the axial skeleton (HP:0009144)1.65989533
145Focal motor seizures (HP:0011153)1.65301921
146Preaxial foot polydactyly (HP:0001841)1.65179013
147Abnormality of the middle phalanges of the toes (HP:0010183)1.64818081
148Mitral regurgitation (HP:0001653)1.64446464
149Thickened helices (HP:0000391)1.64393694
150Diplopia (HP:0000651)1.64054007
151Abnormality of binocular vision (HP:0011514)1.64054007
152Hip contracture (HP:0003273)1.63735439
153Arterial tortuosity (HP:0005116)1.62972522
154Alacrima (HP:0000522)1.62721325
155Megalencephaly (HP:0001355)1.62611174
156Synostosis of carpal bones (HP:0005048)1.62394641
157Aneurysm (HP:0002617)1.61846488
158Elbow flexion contracture (HP:0002987)1.60980953
159Bell-shaped thorax (HP:0001591)1.60861855
160Difficulty running (HP:0009046)1.60794182
161Broad finger (HP:0001500)1.59544292
162Broad phalanges of the hand (HP:0009768)1.58786247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.79374482
2MAPK154.28154625
3DDR24.13320199
4PNCK3.80230442
5EPHB23.53168070
6PDGFRA3.10126948
7CAMK1D2.97926146
8RIPK12.78253901
9LATS12.71885569
10CAMK1G2.70490560
11SIK12.55664860
12TSSK62.48231627
13FGFR22.42413364
14LATS22.05423386
15EEF2K2.00186373
16ICK1.96259997
17MAP3K101.95789486
18CASK1.87651750
19PKN21.85703296
20TYRO31.80519963
21FGFR11.68898225
22PRKD31.66414870
23LMTK21.66232889
24FER1.62105875
25STK241.61189532
26TTN1.58657445
27PTK61.50490683
28BMX1.49532412
29KSR11.46544751
30STK38L1.35404840
31WEE11.35046905
32MAPK71.34915315
33PAK21.33800841
34PAK61.33295347
35AKT31.31417563
36MYLK1.23933607
37CDK61.19820407
38PAK41.18010638
39DMPK1.15353971
40CDK121.13573663
41NLK1.12722829
42FGFR31.12575623
43MST1R1.11138340
44MTOR1.09338234
45BMPR1B1.09250404
46ERN11.08200745
47MET1.06736045
48PDGFRB1.06122622
49PRKCG1.04857735
50ERBB21.04191099
51PTK21.00452776
52TGFBR20.98514350
53NTRK10.93596855
54CDK30.91809850
55PKN10.89916951
56KSR20.89173331
57GRK10.86920157
58ERBB30.83653091
59ILK0.83521230
60MARK10.83288701
61RET0.80586422
62MAPKAPK50.79279119
63ADRBK10.77386226
64SGK2230.77365717
65SGK4940.77365717
66TNIK0.76693362
67STK390.76373350
68STK30.74783334
69NTRK20.72906702
70PTK2B0.71872833
71MAP3K70.71004450
72DAPK20.70589697
73SGK20.70463450
74PINK10.69895020
75PHKG10.69662863
76PHKG20.69662863
77TAOK10.69195596
78PAK30.67996849
79MAPK130.67052878
80PRKCE0.66978409
81LRRK20.66801622
82MAPK120.66321940
83CAMK10.65305108
84SIK20.64028287
85DYRK1A0.63511535
86DYRK1B0.63297736
87MAP2K10.61506736
88PRKCH0.60475728
89CSNK1A1L0.58228155
90MARK20.58197837
91ALK0.57573010
92NEK10.57420834
93KIT0.56371713
94PRKD20.56052647
95PRKD10.56028080
96NTRK30.55571700
97PIK3CA0.54714154
98ROCK10.54295990
99MAP2K20.54106271
100SRC0.53584768
101ROCK20.53413581
102MAPKAPK30.53044529
103CAMK2G0.52621753
104MINK10.52405533
105CAMKK10.51759697
106TIE10.51729729
107TGFBR10.51611152
108MAP3K90.50693892
109AKT20.50663658
110MKNK20.50651301
111DYRK20.49597171
112INSRR0.49427477
113FRK0.48817486
114STK380.48788801
115MAP3K60.48787972
116UHMK10.47268663
117CAMK2A0.47233520
118BRSK20.46270437
119CDK90.45820636
120CAMK2B0.45356996
121CDC42BPA0.44851811
122GSK3A0.42547206
123MAP3K20.42308597
124FGFR40.42095855
125PRKAA20.41350946
126MKNK10.41197824
127CAMK2D0.39584758
128INSR0.39267438
129PRKG10.38973724
130NEK90.37476147
131ADRBK20.37012426
132RPS6KA20.36401140
133CDK50.35238210
134EPHA40.34858089
135MAPK80.34000220
136GRK50.33980125
137CDK140.33072752
138STK110.32965733
139CSNK1G10.31919169
140PDK30.31806884
141PDK40.31806884
142CAMK40.31772697
143IGF1R0.31330728
144VRK10.31260420
145RPS6KA60.31032997
146MAPK90.30412720
147EPHA30.30117527
148SGK10.29649638
149PRKAA10.29536503
150NME10.29468807
151MAPK100.28932699
152BCR0.28776751
153FYN0.27027042

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.76530999
2Hedgehog signaling pathway_Homo sapiens_hsa043402.99761504
3ECM-receptor interaction_Homo sapiens_hsa045122.75190614
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.53819715
5Hippo signaling pathway_Homo sapiens_hsa043902.28375191
6Protein digestion and absorption_Homo sapiens_hsa049742.21697541
7Focal adhesion_Homo sapiens_hsa045102.00908411
8Proteoglycans in cancer_Homo sapiens_hsa052051.89751944
9Wnt signaling pathway_Homo sapiens_hsa043101.84340459
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.76494796
11Adherens junction_Homo sapiens_hsa045201.72841776
12Histidine metabolism_Homo sapiens_hsa003401.67050299
13Melanogenesis_Homo sapiens_hsa049161.64007661
14Axon guidance_Homo sapiens_hsa043601.63287254
15Fatty acid biosynthesis_Homo sapiens_hsa000611.62592706
16Notch signaling pathway_Homo sapiens_hsa043301.60791303
17Prion diseases_Homo sapiens_hsa050201.44217822
18Endometrial cancer_Homo sapiens_hsa052131.42543300
19Colorectal cancer_Homo sapiens_hsa052101.42407724
20Small cell lung cancer_Homo sapiens_hsa052221.36942449
21TGF-beta signaling pathway_Homo sapiens_hsa043501.36094740
22Amoebiasis_Homo sapiens_hsa051461.35279982
23Nicotine addiction_Homo sapiens_hsa050331.34990424
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34822621
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32576884
26AMPK signaling pathway_Homo sapiens_hsa041521.32062953
27Glioma_Homo sapiens_hsa052141.29661555
28Pathways in cancer_Homo sapiens_hsa052001.26453997
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25783263
30Amphetamine addiction_Homo sapiens_hsa050311.25700954
31Chronic myeloid leukemia_Homo sapiens_hsa052201.24872831
32Insulin secretion_Homo sapiens_hsa049111.24404728
33mTOR signaling pathway_Homo sapiens_hsa041501.24041925
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22178855
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22148966
36MicroRNAs in cancer_Homo sapiens_hsa052061.20503993
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.18549777
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17766624
39GABAergic synapse_Homo sapiens_hsa047271.17381627
40PPAR signaling pathway_Homo sapiens_hsa033201.16131659
41Estrogen signaling pathway_Homo sapiens_hsa049151.12241023
42Morphine addiction_Homo sapiens_hsa050321.11766929
43Tight junction_Homo sapiens_hsa045301.11336105
44Bile secretion_Homo sapiens_hsa049761.07921318
45Serotonergic synapse_Homo sapiens_hsa047261.06909588
46Renin secretion_Homo sapiens_hsa049241.06048642
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05520222
48Nitrogen metabolism_Homo sapiens_hsa009101.05334444
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04992129
50Dorso-ventral axis formation_Homo sapiens_hsa043201.02788079
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02629207
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02356555
53PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02227532
54Bladder cancer_Homo sapiens_hsa052191.01490178
55Dilated cardiomyopathy_Homo sapiens_hsa054141.01427405
56Renal cell carcinoma_Homo sapiens_hsa052111.00608159
57Gap junction_Homo sapiens_hsa045400.98744897
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.98036979
59Melanoma_Homo sapiens_hsa052180.96838697
60Rap1 signaling pathway_Homo sapiens_hsa040150.96497765
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95841637
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94410290
63Phototransduction_Homo sapiens_hsa047440.94035578
64VEGF signaling pathway_Homo sapiens_hsa043700.93350068
65Calcium signaling pathway_Homo sapiens_hsa040200.92813475
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92207699
67Type II diabetes mellitus_Homo sapiens_hsa049300.91158452
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90794906
69Insulin signaling pathway_Homo sapiens_hsa049100.90660204
70Linoleic acid metabolism_Homo sapiens_hsa005910.89689179
71Ovarian steroidogenesis_Homo sapiens_hsa049130.88612100
72Insulin resistance_Homo sapiens_hsa049310.87116539
73Circadian rhythm_Homo sapiens_hsa047100.86687877
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86058551
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84145953
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83801615
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83452149
78ErbB signaling pathway_Homo sapiens_hsa040120.81994094
79Prostate cancer_Homo sapiens_hsa052150.81920830
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.81649708
81cAMP signaling pathway_Homo sapiens_hsa040240.81436685
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80462398
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79886981
84GnRH signaling pathway_Homo sapiens_hsa049120.79288953
85HTLV-I infection_Homo sapiens_hsa051660.78800923
86Thyroid cancer_Homo sapiens_hsa052160.78786939
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.77975420
88Circadian entrainment_Homo sapiens_hsa047130.77362040
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76100759
90Oxytocin signaling pathway_Homo sapiens_hsa049210.75826011
91Pancreatic cancer_Homo sapiens_hsa052120.75814951
92Viral myocarditis_Homo sapiens_hsa054160.75447005
93Cardiac muscle contraction_Homo sapiens_hsa042600.75093776
94Non-small cell lung cancer_Homo sapiens_hsa052230.74126468
95Gastric acid secretion_Homo sapiens_hsa049710.73268388
96Salivary secretion_Homo sapiens_hsa049700.72238434
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70936534
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70834645
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70662040
100ABC transporters_Homo sapiens_hsa020100.69671558
101Choline metabolism in cancer_Homo sapiens_hsa052310.68450920
102Oocyte meiosis_Homo sapiens_hsa041140.67932141
103Glucagon signaling pathway_Homo sapiens_hsa049220.67240628
104Glycerolipid metabolism_Homo sapiens_hsa005610.66373122
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.65536596
106Ras signaling pathway_Homo sapiens_hsa040140.65355151
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64993750
108Ether lipid metabolism_Homo sapiens_hsa005650.64816572
109Thyroid hormone synthesis_Homo sapiens_hsa049180.64698904
110Pancreatic secretion_Homo sapiens_hsa049720.64145033
111HIF-1 signaling pathway_Homo sapiens_hsa040660.62426358
112Lysine degradation_Homo sapiens_hsa003100.62394384
113Platelet activation_Homo sapiens_hsa046110.61217209
114Cholinergic synapse_Homo sapiens_hsa047250.61187491
115Endocytosis_Homo sapiens_hsa041440.60841550
116Olfactory transduction_Homo sapiens_hsa047400.60424913
117Dopaminergic synapse_Homo sapiens_hsa047280.60228047
118Arachidonic acid metabolism_Homo sapiens_hsa005900.57739161
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.55110714
120Long-term potentiation_Homo sapiens_hsa047200.54991594
121Toxoplasmosis_Homo sapiens_hsa051450.54288731
122Taste transduction_Homo sapiens_hsa047420.53722832
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52743777
124Cocaine addiction_Homo sapiens_hsa050300.51787017
125MAPK signaling pathway_Homo sapiens_hsa040100.51464510
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50544468
127Glutamatergic synapse_Homo sapiens_hsa047240.49596705
128Long-term depression_Homo sapiens_hsa047300.49318638
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.49105979
130Mineral absorption_Homo sapiens_hsa049780.47877032
131Sphingolipid metabolism_Homo sapiens_hsa006000.47794049
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47457698
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43095424
134Tyrosine metabolism_Homo sapiens_hsa003500.42441133

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