

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | skin morphogenesis (GO:0043589) | 6.06398955 |
| 2 | protein heterotrimerization (GO:0070208) | 5.80497277 |
| 3 | type B pancreatic cell proliferation (GO:0044342) | 5.65334833 |
| 4 | extracellular fibril organization (GO:0043206) | 5.63807504 |
| 5 | protein maturation by protein folding (GO:0022417) | 5.32348469 |
| 6 | substrate-dependent cell migration (GO:0006929) | 5.03043811 |
| 7 | COPI coating of Golgi vesicle (GO:0048205) | 4.88420032 |
| 8 | Golgi transport vesicle coating (GO:0048200) | 4.88420032 |
| 9 | fibril organization (GO:0097435) | 4.80797162 |
| 10 | endodermal cell differentiation (GO:0035987) | 4.69413692 |
| 11 | protein retention in ER lumen (GO:0006621) | 4.67501558 |
| 12 | sequestering of extracellular ligand from receptor (GO:0035581) | 4.54880961 |
| 13 | cell adhesion mediated by integrin (GO:0033627) | 4.51721145 |
| 14 | collagen fibril organization (GO:0030199) | 4.51068753 |
| 15 | kidney mesenchyme development (GO:0072074) | 4.49949188 |
| 16 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 4.49362213 |
| 17 | muscle cell migration (GO:0014812) | 4.31502398 |
| 18 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 4.29512613 |
| 19 | actin filament depolymerization (GO:0030042) | 4.19461252 |
| 20 | chondrocyte proliferation (GO:0035988) | 4.10328279 |
| 21 | response to gravity (GO:0009629) | 4.09436095 |
| 22 | regulation of metalloenzyme activity (GO:0048552) | 3.96770597 |
| 23 | mesodermal cell differentiation (GO:0048333) | 3.96535359 |
| 24 | barbed-end actin filament capping (GO:0051016) | 3.96071682 |
| 25 | virion attachment to host cell (GO:0019062) | 3.90390292 |
| 26 | adhesion of symbiont to host cell (GO:0044650) | 3.90390292 |
| 27 | cellular response to vitamin (GO:0071295) | 3.82911175 |
| 28 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 3.76891808 |
| 29 | negative regulation of smooth muscle cell migration (GO:0014912) | 3.70490473 |
| 30 | protein localization to endosome (GO:0036010) | 3.61421940 |
| 31 | metanephric mesenchyme development (GO:0072075) | 3.58052020 |
| 32 | membrane raft organization (GO:0031579) | 3.56850578 |
| 33 | hemidesmosome assembly (GO:0031581) | 3.54833833 |
| 34 | cellular response to vitamin D (GO:0071305) | 3.54820525 |
| 35 | pattern specification involved in kidney development (GO:0061004) | 3.53739094 |
| 36 | negative regulation of chondrocyte differentiation (GO:0032331) | 3.53632366 |
| 37 | wound healing, spreading of epidermal cells (GO:0035313) | 3.51667345 |
| 38 | mitotic nuclear envelope reassembly (GO:0007084) | 3.47676631 |
| 39 | nuclear envelope reassembly (GO:0031468) | 3.47676631 |
| 40 | peptidyl-proline hydroxylation (GO:0019511) | 3.41662964 |
| 41 | cell migration involved in sprouting angiogenesis (GO:0002042) | 3.41476675 |
| 42 | glomerular visceral epithelial cell development (GO:0072015) | 3.41333008 |
| 43 | protein hydroxylation (GO:0018126) | 3.38933741 |
| 44 | extracellular matrix assembly (GO:0085029) | 3.34097255 |
| 45 | endothelial cell morphogenesis (GO:0001886) | 3.34074613 |
| 46 | collagen metabolic process (GO:0032963) | 3.32365455 |
| 47 | regulation of integrin-mediated signaling pathway (GO:2001044) | 3.26377893 |
| 48 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 3.24747020 |
| 49 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 3.23846224 |
| 50 | endocardial cushion development (GO:0003197) | 3.18665826 |
| 51 | adhesion of symbiont to host (GO:0044406) | 3.17859253 |
| 52 | endocytic recycling (GO:0032456) | 3.16144607 |
| 53 | extracellular negative regulation of signal transduction (GO:1900116) | 3.12833560 |
| 54 | extracellular regulation of signal transduction (GO:1900115) | 3.12833560 |
| 55 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 3.09460791 |
| 56 | regulation of smooth muscle cell migration (GO:0014910) | 3.09412220 |
| 57 | regulation of extracellular matrix disassembly (GO:0010715) | 3.08065836 |
| 58 | positive regulation of actin filament depolymerization (GO:0030836) | 3.06557045 |
| 59 | regulation of collagen metabolic process (GO:0010712) | 3.06164768 |
| 60 | collagen catabolic process (GO:0030574) | 3.05121011 |
| 61 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.04039694 |
| 62 | hypotonic response (GO:0006971) | 3.03140532 |
| 63 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) | 3.02653245 |
| 64 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.00914636 |
| 65 | SMAD protein complex assembly (GO:0007183) | 2.99543881 |
| 66 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.96796041 |
| 67 | cortical actin cytoskeleton organization (GO:0030866) | 2.96534535 |
| 68 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.94203304 |
| 69 | positive regulation of osteoblast proliferation (GO:0033690) | 2.92996470 |
| 70 | positive regulation of axon extension (GO:0045773) | 2.92296656 |
| 71 | negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394) | 2.92236725 |
| 72 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.91594834 |
| 73 | wound healing, spreading of cells (GO:0044319) | 2.89984013 |
| 74 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.88989938 |
| 75 | glomerular epithelial cell development (GO:0072310) | 2.88216420 |
| 76 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.87368459 |
| 77 | bone trabecula formation (GO:0060346) | 2.86585542 |
| 78 | extracellular matrix disassembly (GO:0022617) | 2.85726446 |
| 79 | lipopolysaccharide biosynthetic process (GO:0009103) | 2.84960810 |
| 80 | mesenchymal cell differentiation involved in kidney development (GO:0072161) | 2.84690722 |
| 81 | mesenchymal cell differentiation involved in renal system development (GO:2001012) | 2.84690722 |
| 82 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 2.84190388 |
| 83 | cell-substrate junction assembly (GO:0007044) | 2.83339532 |
| 84 | basement membrane organization (GO:0071711) | 2.81342775 |
| 85 | endothelial cell chemotaxis (GO:0035767) | 2.80724740 |
| 86 | multicellular organismal metabolic process (GO:0044236) | 2.80237790 |
| 87 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 2.79934441 |
| 88 | cell migration involved in heart development (GO:0060973) | 2.76601300 |
| 89 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.75887954 |
| 90 | stress fiber assembly (GO:0043149) | 2.75564297 |
| 91 | multicellular organismal catabolic process (GO:0044243) | 2.74386273 |
| 92 | establishment of viral latency (GO:0019043) | 2.73505366 |
| 93 | cortical cytoskeleton organization (GO:0030865) | 2.73309853 |
| 94 | regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307) | 2.71436029 |
| 95 | extracellular matrix organization (GO:0030198) | 2.71310337 |
| 96 | negative regulation of stem cell proliferation (GO:2000647) | 2.70384694 |
| 97 | extracellular structure organization (GO:0043062) | 2.70207388 |
| 98 | positive regulation of collagen biosynthetic process (GO:0032967) | 2.67569327 |
| 99 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 2.63540716 |
| 100 | negative regulation of anoikis (GO:2000811) | 2.63361471 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 5.54193424 |
| 2 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 5.40924888 |
| 3 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 4.44727035 |
| 4 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 4.09057581 |
| 5 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.31722784 |
| 6 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 3.23500611 |
| 7 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 3.15434281 |
| 8 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.96125155 |
| 9 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.95612493 |
| 10 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.92258407 |
| 11 | BRD4_25478319_ChIP-Seq_HGPS_Human | 2.90387987 |
| 12 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 2.86082197 |
| 13 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.69494192 |
| 14 | * CJUN_26792858_Chip-Seq_BT549_Human | 2.52700084 |
| 15 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.47464320 |
| 16 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.44996205 |
| 17 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.43297014 |
| 18 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 2.32672734 |
| 19 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 2.32672734 |
| 20 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.27963422 |
| 21 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 2.03994992 |
| 22 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 2.03182094 |
| 23 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.96353657 |
| 24 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.96135273 |
| 25 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.92998474 |
| 26 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.88222904 |
| 27 | ATF3_27146783_Chip-Seq_COLON_Human | 1.87295211 |
| 28 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.83704448 |
| 29 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.80247662 |
| 30 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.79960818 |
| 31 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.78744471 |
| 32 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.78386788 |
| 33 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.73025047 |
| 34 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.72436615 |
| 35 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.69686742 |
| 36 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.62365484 |
| 37 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.59654423 |
| 38 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.55503300 |
| 39 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.52312039 |
| 40 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.51304963 |
| 41 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.46958118 |
| 42 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.46681113 |
| 43 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.46112915 |
| 44 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.45812183 |
| 45 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.44308061 |
| 46 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.43421963 |
| 47 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.42418470 |
| 48 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.39997119 |
| 49 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.39547856 |
| 50 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.38346513 |
| 51 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.33695981 |
| 52 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.33312905 |
| 53 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.33192300 |
| 54 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.32248267 |
| 55 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.31954924 |
| 56 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.29201666 |
| 57 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.26125141 |
| 58 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.23526488 |
| 59 | SA1_22415368_ChIP-Seq_MEFs_Mouse | 1.22577695 |
| 60 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.22338055 |
| 61 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.22064267 |
| 62 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.21578284 |
| 63 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.20568726 |
| 64 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.14414509 |
| 65 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.10518803 |
| 66 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.10059652 |
| 67 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.08246864 |
| 68 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.08220961 |
| 69 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.08220961 |
| 70 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.08024715 |
| 71 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.07827534 |
| 72 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.06688674 |
| 73 | * CSB_26484114_Chip-Seq_FIBROBLAST_Human | 1.05769353 |
| 74 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.03197920 |
| 75 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.02071422 |
| 76 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.01623066 |
| 77 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.99866844 |
| 78 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.98635483 |
| 79 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.97581773 |
| 80 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.97257997 |
| 81 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.97257997 |
| 82 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.94971307 |
| 83 | NFI_21473784_ChIP-Seq_ESCs_Mouse | 0.94632751 |
| 84 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.94161064 |
| 85 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.91441960 |
| 86 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.90759648 |
| 87 | TP53_16413492_ChIP-PET_HCT116_Human | 0.90207590 |
| 88 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.86922193 |
| 89 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.86010205 |
| 90 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.85549879 |
| 91 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.85541712 |
| 92 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.85535552 |
| 93 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.84121095 |
| 94 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.83877170 |
| 95 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.82406762 |
| 96 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.82202088 |
| 97 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.79301941 |
| 98 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.79297826 |
| 99 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.78978161 |
| 100 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.77734036 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 7.73795315 |
| 2 | MP0005257_abnormal_intraocular_pressure | 4.23819989 |
| 3 | MP0003705_abnormal_hypodermis_morpholog | 4.12751882 |
| 4 | MP0004272_abnormal_basement_membrane | 4.04488401 |
| 5 | MP0003279_aneurysm | 4.02048287 |
| 6 | MP0001958_emphysema | 3.44021308 |
| 7 | MP0005275_abnormal_skin_tensile | 3.38705287 |
| 8 | MP0005503_abnormal_tendon_morphology | 3.17259735 |
| 9 | MP0003950_abnormal_plasma_membrane | 2.99464676 |
| 10 | MP0003566_abnormal_cell_adhesion | 2.99111088 |
| 11 | MP0001542_abnormal_bone_strength | 2.73521019 |
| 12 | MP0010368_abnormal_lymphatic_system | 2.72193537 |
| 13 | MP0000751_myopathy | 2.71018633 |
| 14 | MP0006054_spinal_hemorrhage | 2.51483091 |
| 15 | MP0010030_abnormal_orbit_morphology | 2.20862700 |
| 16 | MP0002060_abnormal_skin_morphology | 2.20825527 |
| 17 | MP0005623_abnormal_meninges_morphology | 2.19315344 |
| 18 | MP0004510_myositis | 2.17232846 |
| 19 | MP0009780_abnormal_chondrocyte_physiolo | 2.14031267 |
| 20 | MP0009384_cardiac_valve_regurgitation | 2.11702086 |
| 21 | MP0005023_abnormal_wound_healing | 2.04969546 |
| 22 | MP0000013_abnormal_adipose_tissue | 1.96157525 |
| 23 | MP0000767_abnormal_smooth_muscle | 1.93901055 |
| 24 | MP0003091_abnormal_cell_migration | 1.91698730 |
| 25 | MP0002877_abnormal_melanocyte_morpholog | 1.85924750 |
| 26 | MP0003191_abnormal_cellular_cholesterol | 1.81093078 |
| 27 | MP0001299_abnormal_eye_distance/ | 1.75978931 |
| 28 | MP0005508_abnormal_skeleton_morphology | 1.64819688 |
| 29 | MP0000749_muscle_degeneration | 1.63263433 |
| 30 | MP0002295_abnormal_pulmonary_circulatio | 1.59914914 |
| 31 | MP0001243_abnormal_dermal_layer | 1.59138567 |
| 32 | MP0002896_abnormal_bone_mineralization | 1.54472988 |
| 33 | MP0000534_abnormal_ureter_morphology | 1.48035589 |
| 34 | MP0009840_abnormal_foam_cell | 1.43545061 |
| 35 | MP0005165_increased_susceptibility_to | 1.36056900 |
| 36 | MP0000750_abnormal_muscle_regeneration | 1.31949485 |
| 37 | MP0000003_abnormal_adipose_tissue | 1.30545488 |
| 38 | MP0002332_abnormal_exercise_endurance | 1.26425030 |
| 39 | MP0000733_abnormal_muscle_development | 1.21486933 |
| 40 | MP0010352_gastrointestinal_tract_polyps | 1.20662438 |
| 41 | MP0009250_abnormal_appendicular_skeleto | 1.17274427 |
| 42 | MP0005595_abnormal_vascular_smooth | 1.16383661 |
| 43 | MP0004134_abnormal_chest_morphology | 1.13579902 |
| 44 | MP0003941_abnormal_skin_development | 1.12407503 |
| 45 | MP0001879_abnormal_lymphatic_vessel | 1.10888572 |
| 46 | MP0005164_abnormal_response_to | 1.10191751 |
| 47 | MP0002254_reproductive_system_inflammat | 1.08319262 |
| 48 | MP0004858_abnormal_nervous_system | 1.07773887 |
| 49 | MP0009053_abnormal_anal_canal | 1.06641119 |
| 50 | MP0005390_skeleton_phenotype | 1.05527571 |
| 51 | MP0000762_abnormal_tongue_morphology | 1.05214114 |
| 52 | MP0005197_abnormal_uvea_morphology | 1.04359354 |
| 53 | MP0003942_abnormal_urinary_system | 1.03140531 |
| 54 | MP0010386_abnormal_urinary_bladder | 1.01474774 |
| 55 | MP0000343_altered_response_to | 1.01415158 |
| 56 | MP0000759_abnormal_skeletal_muscle | 1.00170731 |
| 57 | MP0002933_joint_inflammation | 0.96011223 |
| 58 | MP0003123_paternal_imprinting | 0.95141472 |
| 59 | MP0000163_abnormal_cartilage_morphology | 0.92304137 |
| 60 | MP0003385_abnormal_body_wall | 0.90159317 |
| 61 | MP0005058_abnormal_lysosome_morphology | 0.90059882 |
| 62 | MP0002177_abnormal_outer_ear | 0.89571182 |
| 63 | MP0002108_abnormal_muscle_morphology | 0.88075018 |
| 64 | MP0001849_ear_inflammation | 0.86955575 |
| 65 | MP0002932_abnormal_joint_morphology | 0.85432543 |
| 66 | MP0002282_abnormal_trachea_morphology | 0.85099733 |
| 67 | MP0003075_altered_response_to | 0.84347792 |
| 68 | MP0002168_other_aberrant_phenotype | 0.83526623 |
| 69 | MP0005330_cardiomyopathy | 0.79960399 |
| 70 | MP0002113_abnormal_skeleton_development | 0.79687010 |
| 71 | MP0000858_altered_metastatic_potential | 0.79132485 |
| 72 | MP0001614_abnormal_blood_vessel | 0.77747936 |
| 73 | MP0002998_abnormal_bone_remodeling | 0.76565340 |
| 74 | MP0001915_intracranial_hemorrhage | 0.75808514 |
| 75 | MP0003283_abnormal_digestive_organ | 0.73235376 |
| 76 | MP0003795_abnormal_bone_structure | 0.67131117 |
| 77 | MP0002128_abnormal_blood_circulation | 0.65654048 |
| 78 | MP0000428_abnormal_craniofacial_morphol | 0.64297156 |
| 79 | MP0003448_altered_tumor_morphology | 0.62902412 |
| 80 | MP0008775_abnormal_heart_ventricle | 0.62877570 |
| 81 | MP0001533_abnormal_skeleton_physiology | 0.62535267 |
| 82 | MP0002115_abnormal_skeleton_extremities | 0.62280128 |
| 83 | MP0001175_abnormal_lung_morphology | 0.61652823 |
| 84 | MP0005193_abnormal_anterior_eye | 0.59164200 |
| 85 | MP0002925_abnormal_cardiovascular_devel | 0.57902532 |
| 86 | MP0010771_integument_phenotype | 0.57298146 |
| 87 | MP0000432_abnormal_head_morphology | 0.54820269 |
| 88 | MP0003045_fibrosis | 0.54660318 |
| 89 | MP0004087_abnormal_muscle_fiber | 0.54496285 |
| 90 | MP0003115_abnormal_respiratory_system | 0.53824248 |
| 91 | MP0004233_abnormal_muscle_weight | 0.53803645 |
| 92 | MP0003453_abnormal_keratinocyte_physiol | 0.53587478 |
| 93 | MP0005369_muscle_phenotype | 0.53197248 |
| 94 | MP0005621_abnormal_cell_physiology | 0.52074625 |
| 95 | MP0002972_abnormal_cardiac_muscle | 0.50842641 |
| 96 | MP0003329_amyloid_beta_deposits | 0.50601020 |
| 97 | MP0003828_pulmonary_edema | 0.49985228 |
| 98 | MP0000249_abnormal_blood_vessel | 0.48568825 |
| 99 | MP0002106_abnormal_muscle_physiology | 0.46679606 |
| 100 | MP0003755_abnormal_palate_morphology | 0.45444695 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Premature rupture of membranes (HP:0001788) | 9.11810861 |
| 2 | Protrusio acetabuli (HP:0003179) | 6.93180015 |
| 3 | Ankle contracture (HP:0006466) | 5.12644349 |
| 4 | Follicular hyperkeratosis (HP:0007502) | 4.96107395 |
| 5 | Atrophic scars (HP:0001075) | 4.66975579 |
| 6 | Aortic dissection (HP:0002647) | 4.59864141 |
| 7 | Spinal rigidity (HP:0003306) | 4.31820707 |
| 8 | Type 1 muscle fiber predominance (HP:0003803) | 4.18806351 |
| 9 | Bladder diverticulum (HP:0000015) | 4.02653244 |
| 10 | Slender build (HP:0001533) | 3.97003390 |
| 11 | Soft skin (HP:0000977) | 3.86764651 |
| 12 | Abnormality of dentin (HP:0010299) | 3.83919155 |
| 13 | Vertebral compression fractures (HP:0002953) | 3.79744298 |
| 14 | Fragile skin (HP:0001030) | 3.68880691 |
| 15 | Aortic aneurysm (HP:0004942) | 3.58631526 |
| 16 | Wormian bones (HP:0002645) | 3.55811991 |
| 17 | Vascular tortuosity (HP:0004948) | 3.53958126 |
| 18 | Mildly elevated creatine phosphokinase (HP:0008180) | 3.34442226 |
| 19 | Arterial tortuosity (HP:0005116) | 3.30585336 |
| 20 | Genu recurvatum (HP:0002816) | 3.28928242 |
| 21 | Cervical subluxation (HP:0003308) | 3.21137704 |
| 22 | Blue sclerae (HP:0000592) | 3.19272403 |
| 23 | Shallow orbits (HP:0000586) | 3.16884437 |
| 24 | Peritonitis (HP:0002586) | 3.13899486 |
| 25 | Cardiovascular calcification (HP:0011915) | 3.11885320 |
| 26 | Neonatal short-limb short stature (HP:0008921) | 3.11452813 |
| 27 | Osteolytic defects of the hand bones (HP:0009699) | 3.09057336 |
| 28 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 3.09057336 |
| 29 | Short nail (HP:0001799) | 2.98716360 |
| 30 | Broad metatarsal (HP:0001783) | 2.97137432 |
| 31 | Increased connective tissue (HP:0009025) | 2.95635043 |
| 32 | Dilatation of the ascending aorta (HP:0005111) | 2.86508395 |
| 33 | Elbow flexion contracture (HP:0002987) | 2.86360574 |
| 34 | Upper limb amyotrophy (HP:0009129) | 2.85283936 |
| 35 | Distal upper limb amyotrophy (HP:0007149) | 2.85283936 |
| 36 | Biconcave vertebral bodies (HP:0004586) | 2.84142309 |
| 37 | Generalized amyotrophy (HP:0003700) | 2.80836646 |
| 38 | Increased variability in muscle fiber diameter (HP:0003557) | 2.80155055 |
| 39 | Spondylolisthesis (HP:0003302) | 2.78562378 |
| 40 | Bowel diverticulosis (HP:0005222) | 2.77395210 |
| 41 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.74853015 |
| 42 | Joint stiffness (HP:0001387) | 2.74811819 |
| 43 | Achilles tendon contracture (HP:0001771) | 2.70781691 |
| 44 | Mitral regurgitation (HP:0001653) | 2.65304127 |
| 45 | Joint laxity (HP:0001388) | 2.64886349 |
| 46 | Abnormal delivery (HP:0001787) | 2.57090318 |
| 47 | Hypoventilation (HP:0002791) | 2.55950594 |
| 48 | Hand muscle atrophy (HP:0009130) | 2.52796430 |
| 49 | Glucose intolerance (HP:0000833) | 2.51487285 |
| 50 | Limb-girdle muscle weakness (HP:0003325) | 2.50554517 |
| 51 | Aortic regurgitation (HP:0001659) | 2.50302980 |
| 52 | Distal lower limb amyotrophy (HP:0008944) | 2.49835094 |
| 53 | Hyperextensible skin (HP:0000974) | 2.46450591 |
| 54 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.45809722 |
| 55 | Vascular calcification (HP:0004934) | 2.45713804 |
| 56 | Distal lower limb muscle weakness (HP:0009053) | 2.40059164 |
| 57 | Abnormality of the Achilles tendon (HP:0005109) | 2.38391669 |
| 58 | Natal tooth (HP:0000695) | 2.37195188 |
| 59 | Mitral valve prolapse (HP:0001634) | 2.36276835 |
| 60 | Cerebral aneurysm (HP:0004944) | 2.21459254 |
| 61 | Difficulty climbing stairs (HP:0003551) | 2.18885134 |
| 62 | Bradycardia (HP:0001662) | 2.18614317 |
| 63 | Ectopia lentis (HP:0001083) | 2.17051392 |
| 64 | Delayed gross motor development (HP:0002194) | 2.16254036 |
| 65 | Protruding ear (HP:0000411) | 2.15172172 |
| 66 | Aortic valve stenosis (HP:0001650) | 2.14482677 |
| 67 | Long toe (HP:0010511) | 2.05191530 |
| 68 | Abnormality of the acetabulum (HP:0003170) | 2.04701408 |
| 69 | Overgrowth (HP:0001548) | 2.04502917 |
| 70 | Entropion (HP:0000621) | 2.03033062 |
| 71 | Mitral stenosis (HP:0001718) | 2.01955282 |
| 72 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.01132802 |
| 73 | Limb-girdle muscle atrophy (HP:0003797) | 2.00312647 |
| 74 | Wrist flexion contracture (HP:0001239) | 1.99301007 |
| 75 | Ulnar bowing (HP:0003031) | 1.97676742 |
| 76 | Thin skin (HP:0000963) | 1.96040294 |
| 77 | Short clavicles (HP:0000894) | 1.95446721 |
| 78 | Lower limb amyotrophy (HP:0007210) | 1.94983742 |
| 79 | Hyperacusis (HP:0010780) | 1.92971383 |
| 80 | Insulin resistance (HP:0000855) | 1.91184864 |
| 81 | Osteopenia (HP:0000938) | 1.87484803 |
| 82 | Infantile muscular hypotonia (HP:0008947) | 1.85871038 |
| 83 | Renal duplication (HP:0000075) | 1.84990814 |
| 84 | Insomnia (HP:0100785) | 1.84634287 |
| 85 | Myocardial infarction (HP:0001658) | 1.84389569 |
| 86 | Camptodactyly of toe (HP:0001836) | 1.84185414 |
| 87 | Round ear (HP:0100830) | 1.83446202 |
| 88 | Mild short stature (HP:0003502) | 1.83344326 |
| 89 | Disproportionate tall stature (HP:0001519) | 1.83230648 |
| 90 | Congenital glaucoma (HP:0001087) | 1.83179246 |
| 91 | Coxa vara (HP:0002812) | 1.82648621 |
| 92 | Breech presentation (HP:0001623) | 1.79503085 |
| 93 | Upper limb muscle weakness (HP:0003484) | 1.77943278 |
| 94 | Nuclear cataract (HP:0100018) | 1.77071678 |
| 95 | Abnormality of skull ossification (HP:0002703) | 1.76633779 |
| 96 | Abnormality of the umbilical cord (HP:0010881) | 1.76194283 |
| 97 | Aneurysm (HP:0002617) | 1.74798637 |
| 98 | Flat cornea (HP:0007720) | 1.73864874 |
| 99 | Delayed cranial suture closure (HP:0000270) | 1.73642617 |
| 100 | Hallux valgus (HP:0001822) | 1.71951764 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TESK1 | 4.69034298 |
| 2 | LIMK1 | 4.24991377 |
| 3 | EPHA2 | 3.37825913 |
| 4 | MYLK | 3.07268315 |
| 5 | NME2 | 3.05822353 |
| 6 | PTK2 | 2.86621626 |
| 7 | LMTK2 | 2.66021326 |
| 8 | ERN1 | 2.53407660 |
| 9 | TESK2 | 2.51896837 |
| 10 | PDGFRA | 2.50590813 |
| 11 | TTN | 2.42439453 |
| 12 | PAK4 | 2.38927703 |
| 13 | EPHB2 | 2.33736237 |
| 14 | ARAF | 2.31122686 |
| 15 | MST1R | 2.27943383 |
| 16 | MOS | 2.24126579 |
| 17 | VRK2 | 2.13451429 |
| 18 | TGFBR2 | 2.10913423 |
| 19 | IRAK3 | 2.09843818 |
| 20 | PIM2 | 1.87654657 |
| 21 | ERBB4 | 1.86051004 |
| 22 | TAOK2 | 1.73855860 |
| 23 | MET | 1.67766268 |
| 24 | ABL2 | 1.58324100 |
| 25 | MAP3K3 | 1.44966594 |
| 26 | STK38 | 1.44432274 |
| 27 | DDR2 | 1.43350864 |
| 28 | PRKD2 | 1.37406856 |
| 29 | NTRK1 | 1.36426144 |
| 30 | SIK1 | 1.36327909 |
| 31 | LATS2 | 1.35616377 |
| 32 | PAK2 | 1.33359847 |
| 33 | NEK9 | 1.30436831 |
| 34 | PTK2B | 1.25563654 |
| 35 | ICK | 1.17576472 |
| 36 | ILK | 1.11762472 |
| 37 | EPHB1 | 1.06019021 |
| 38 | STK10 | 1.02648370 |
| 39 | CDK8 | 1.01143184 |
| 40 | RIPK1 | 0.99865562 |
| 41 | FLT3 | 0.99855812 |
| 42 | BUB1 | 0.99789229 |
| 43 | ROCK2 | 0.98266484 |
| 44 | HIPK2 | 0.94887452 |
| 45 | BMX | 0.92769398 |
| 46 | MAP3K6 | 0.92012349 |
| 47 | MAP3K12 | 0.89535081 |
| 48 | ROCK1 | 0.88698498 |
| 49 | ADRBK1 | 0.88331790 |
| 50 | TRPM7 | 0.87832755 |
| 51 | DAPK3 | 0.87791573 |
| 52 | LATS1 | 0.83815076 |
| 53 | PAK1 | 0.80467371 |
| 54 | PRPF4B | 0.78286885 |
| 55 | GRK7 | 0.76549823 |
| 56 | PHKG2 | 0.75285998 |
| 57 | PHKG1 | 0.75285998 |
| 58 | CDC42BPA | 0.72790163 |
| 59 | DAPK1 | 0.72070255 |
| 60 | MAPKAPK3 | 0.71552215 |
| 61 | DMPK | 0.68847801 |
| 62 | BRAF | 0.68179906 |
| 63 | MAP2K7 | 0.68176975 |
| 64 | SCYL2 | 0.66840778 |
| 65 | MAP2K3 | 0.64951885 |
| 66 | PRKG2 | 0.62054163 |
| 67 | GSK3A | 0.60540101 |
| 68 | MTOR | 0.53730519 |
| 69 | PDGFRB | 0.53649543 |
| 70 | STK16 | 0.50059739 |
| 71 | TRIB3 | 0.49520699 |
| 72 | SMG1 | 0.49127088 |
| 73 | MAP3K8 | 0.48103052 |
| 74 | PAK6 | 0.47765710 |
| 75 | PTK6 | 0.47738915 |
| 76 | MAPKAPK2 | 0.42529432 |
| 77 | TBK1 | 0.41677374 |
| 78 | MELK | 0.41604931 |
| 79 | CDK14 | 0.41173509 |
| 80 | STK38L | 0.39711071 |
| 81 | GRK5 | 0.39289780 |
| 82 | AURKA | 0.38738869 |
| 83 | CDK15 | 0.36525214 |
| 84 | CDK18 | 0.35806758 |
| 85 | CAMK2G | 0.33947194 |
| 86 | RPS6KA2 | 0.33389758 |
| 87 | MAP3K11 | 0.33319461 |
| 88 | STK3 | 0.32739375 |
| 89 | CDK11A | 0.32574948 |
| 90 | STK4 | 0.32357907 |
| 91 | PRKD1 | 0.29981060 |
| 92 | NEK1 | 0.29258379 |
| 93 | PKN2 | 0.29204401 |
| 94 | WNK1 | 0.28736555 |
| 95 | PIK3CG | 0.28710446 |
| 96 | KDR | 0.26531059 |
| 97 | BRSK1 | 0.25859414 |
| 98 | PRKCE | 0.24713538 |
| 99 | CSNK1G3 | 0.24373005 |
| 100 | CSNK1A1L | 0.23055917 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 4.08377063 |
| 2 | ECM-receptor interaction_Homo sapiens_hsa04512 | 3.87665560 |
| 3 | Focal adhesion_Homo sapiens_hsa04510 | 3.09952148 |
| 4 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 2.60469290 |
| 5 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 2.39068630 |
| 6 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.35562426 |
| 7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.14197047 |
| 8 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 2.07850044 |
| 9 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 2.07471570 |
| 10 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.07274796 |
| 11 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 2.01923501 |
| 12 | Galactose metabolism_Homo sapiens_hsa00052 | 1.92773095 |
| 13 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.86000072 |
| 14 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.85929077 |
| 15 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.78537175 |
| 16 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.76651804 |
| 17 | Amoebiasis_Homo sapiens_hsa05146 | 1.71346472 |
| 18 | Bladder cancer_Homo sapiens_hsa05219 | 1.69661445 |
| 19 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.64614050 |
| 20 | Proteasome_Homo sapiens_hsa03050 | 1.60145824 |
| 21 | Other glycan degradation_Homo sapiens_hsa00511 | 1.49974324 |
| 22 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.47715671 |
| 23 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.43990747 |
| 24 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.42011154 |
| 25 | Shigellosis_Homo sapiens_hsa05131 | 1.41186179 |
| 26 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.40298236 |
| 27 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.37127193 |
| 28 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.35702546 |
| 29 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.33512840 |
| 30 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.31297272 |
| 31 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.28333918 |
| 32 | Adherens junction_Homo sapiens_hsa04520 | 1.28048328 |
| 33 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.27773461 |
| 34 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.21363835 |
| 35 | Sulfur relay system_Homo sapiens_hsa04122 | 1.20459840 |
| 36 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.13601937 |
| 37 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.12610906 |
| 38 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.10712154 |
| 39 | Salivary secretion_Homo sapiens_hsa04970 | 1.05307459 |
| 40 | Melanoma_Homo sapiens_hsa05218 | 1.04259108 |
| 41 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.02083472 |
| 42 | Lysosome_Homo sapiens_hsa04142 | 1.01239129 |
| 43 | Salmonella infection_Homo sapiens_hsa05132 | 0.96150261 |
| 44 | Endocytosis_Homo sapiens_hsa04144 | 0.95312362 |
| 45 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.94515990 |
| 46 | Pathways in cancer_Homo sapiens_hsa05200 | 0.91485043 |
| 47 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.90579389 |
| 48 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.89388670 |
| 49 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.88754505 |
| 50 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.87298101 |
| 51 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.86697506 |
| 52 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.81982286 |
| 53 | Malaria_Homo sapiens_hsa05144 | 0.80564960 |
| 54 | Prion diseases_Homo sapiens_hsa05020 | 0.80172067 |
| 55 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.79852797 |
| 56 | Axon guidance_Homo sapiens_hsa04360 | 0.79657475 |
| 57 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.78352575 |
| 58 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.76499674 |
| 59 | Thyroid cancer_Homo sapiens_hsa05216 | 0.76360622 |
| 60 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.74494553 |
| 61 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.73469002 |
| 62 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.63848368 |
| 63 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.62028308 |
| 64 | Gap junction_Homo sapiens_hsa04540 | 0.60990460 |
| 65 | Prostate cancer_Homo sapiens_hsa05215 | 0.58614703 |
| 66 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.58014395 |
| 67 | Melanogenesis_Homo sapiens_hsa04916 | 0.56467869 |
| 68 | Apoptosis_Homo sapiens_hsa04210 | 0.56325036 |
| 69 | Pertussis_Homo sapiens_hsa05133 | 0.55926578 |
| 70 | Tight junction_Homo sapiens_hsa04530 | 0.55206702 |
| 71 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.55045251 |
| 72 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.52601399 |
| 73 | Protein export_Homo sapiens_hsa03060 | 0.52061655 |
| 74 | Insulin secretion_Homo sapiens_hsa04911 | 0.49572122 |
| 75 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49499941 |
| 76 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.49079268 |
| 77 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.47486173 |
| 78 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.46604793 |
| 79 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.43345950 |
| 80 | Phagosome_Homo sapiens_hsa04145 | 0.42808130 |
| 81 | Hepatitis B_Homo sapiens_hsa05161 | 0.41773192 |
| 82 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.41116564 |
| 83 | Cocaine addiction_Homo sapiens_hsa05030 | 0.40370802 |
| 84 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.40174773 |
| 85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39439198 |
| 86 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.37687029 |
| 87 | Endometrial cancer_Homo sapiens_hsa05213 | 0.36628461 |
| 88 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.35364434 |
| 89 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.34913483 |
| 90 | HTLV-I infection_Homo sapiens_hsa05166 | 0.34862965 |
| 91 | Glioma_Homo sapiens_hsa05214 | 0.34584732 |
| 92 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.32827546 |
| 93 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.32139484 |
| 94 | RNA polymerase_Homo sapiens_hsa03020 | 0.32029641 |
| 95 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.31832942 |
| 96 | Circadian rhythm_Homo sapiens_hsa04710 | 0.31601136 |
| 97 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.30217626 |
| 98 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.29602139 |
| 99 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.28708671 |
| 100 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.28456327 |

