APCS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.92252751
2exogenous drug catabolic process (GO:0042738)7.78828202
3omega-hydroxylase P450 pathway (GO:0097267)7.62932259
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.45117314
5L-phenylalanine catabolic process (GO:0006559)7.45117314
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.12880537
7L-phenylalanine metabolic process (GO:0006558)7.12880537
8aromatic amino acid family catabolic process (GO:0009074)6.65127355
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.61665905
10negative regulation of fibrinolysis (GO:0051918)6.15003479
11glucuronate metabolic process (GO:0019585)6.07818559
12uronic acid metabolic process (GO:0006063)6.07818559
13glyoxylate metabolic process (GO:0046487)6.03606033
14tryptophan catabolic process (GO:0006569)5.99996539
15indole-containing compound catabolic process (GO:0042436)5.99996539
16indolalkylamine catabolic process (GO:0046218)5.99996539
17drug metabolic process (GO:0017144)5.98946434
18oxidative demethylation (GO:0070989)5.96916178
19kynurenine metabolic process (GO:0070189)5.93679648
20regulation of fibrinolysis (GO:0051917)5.91085310
21high-density lipoprotein particle remodeling (GO:0034375)5.84746504
22regulation of protein activation cascade (GO:2000257)5.81311985
23bile acid biosynthetic process (GO:0006699)5.77641672
24complement activation, alternative pathway (GO:0006957)5.66973825
25protein carboxylation (GO:0018214)5.63921847
26peptidyl-glutamic acid carboxylation (GO:0017187)5.63921847
27tryptophan metabolic process (GO:0006568)5.63115369
28urea cycle (GO:0000050)5.61656553
29urea metabolic process (GO:0019627)5.61656553
30alpha-linolenic acid metabolic process (GO:0036109)5.47370267
31regulation of humoral immune response (GO:0002920)5.34445522
32cysteine metabolic process (GO:0006534)5.32830194
33regulation of complement activation (GO:0030449)5.32309814
34reverse cholesterol transport (GO:0043691)5.26462205
35sulfur amino acid catabolic process (GO:0000098)5.24857821
36phenylpropanoid metabolic process (GO:0009698)5.21469396
37nitrogen cycle metabolic process (GO:0071941)5.15698871
38regulation of cholesterol esterification (GO:0010872)5.11877404
39plasma lipoprotein particle remodeling (GO:0034369)5.08211128
40protein-lipid complex remodeling (GO:0034368)5.08211128
41macromolecular complex remodeling (GO:0034367)5.08211128
42regulation of triglyceride catabolic process (GO:0010896)5.05580966
43serine family amino acid catabolic process (GO:0009071)5.03805819
44bile acid metabolic process (GO:0008206)4.95759284
45ethanol metabolic process (GO:0006067)4.92114176
46negative regulation of hemostasis (GO:1900047)4.87813640
47negative regulation of blood coagulation (GO:0030195)4.87813640
48phospholipid efflux (GO:0033700)4.82347675
49aromatic amino acid family metabolic process (GO:0009072)4.81931088
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81682240
51acylglycerol homeostasis (GO:0055090)4.78032375
52triglyceride homeostasis (GO:0070328)4.78032375
53tyrosine metabolic process (GO:0006570)4.70722765
54plasma lipoprotein particle clearance (GO:0034381)4.60760739
55homocysteine metabolic process (GO:0050667)4.56530085
56negative regulation of complement activation (GO:0045916)4.54457967
57negative regulation of cholesterol transport (GO:0032375)4.52071888
58negative regulation of sterol transport (GO:0032372)4.52071888
59amino-acid betaine metabolic process (GO:0006577)4.50766728
60alpha-amino acid catabolic process (GO:1901606)4.49212109
61negative regulation of coagulation (GO:0050819)4.48159571
62cellular ketone body metabolic process (GO:0046950)4.47271010
63cholesterol efflux (GO:0033344)4.46529660
64hormone catabolic process (GO:0042447)4.42159379
65lysine metabolic process (GO:0006553)4.39895187
66lysine catabolic process (GO:0006554)4.39895187
67fibrinolysis (GO:0042730)4.33901139
68glycine metabolic process (GO:0006544)4.31054870
69S-adenosylmethionine metabolic process (GO:0046500)4.30274487
70alkaloid metabolic process (GO:0009820)4.29851963
71blood coagulation, intrinsic pathway (GO:0007597)4.24731486
72bile acid and bile salt transport (GO:0015721)4.23424421
73indolalkylamine metabolic process (GO:0006586)4.22748650
74coenzyme catabolic process (GO:0009109)4.21781066
75* negative regulation of wound healing (GO:0061045)4.21414126
76plasma lipoprotein particle assembly (GO:0034377)4.20256782
77imidazole-containing compound metabolic process (GO:0052803)4.16182362
78glutamate metabolic process (GO:0006536)4.14896425
79negative regulation of protein activation cascade (GO:2000258)4.14689406
80cellular biogenic amine catabolic process (GO:0042402)4.13582748
81amine catabolic process (GO:0009310)4.13582748
82cellular amino acid catabolic process (GO:0009063)4.12549082
83positive regulation of lipoprotein lipase activity (GO:0051006)4.11497052
84positive regulation of triglyceride lipase activity (GO:0061365)4.11497052
85* acute-phase response (GO:0006953)4.09398700
86serine family amino acid metabolic process (GO:0009069)4.07278515
87aldehyde catabolic process (GO:0046185)4.04032899
88low-density lipoprotein particle remodeling (GO:0034374)4.03301134
89protein activation cascade (GO:0072376)4.02253400
90disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.01182779
91killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.01182779
92benzene-containing compound metabolic process (GO:0042537)4.00440708
93dicarboxylic acid biosynthetic process (GO:0043650)4.00179998
94flavonoid metabolic process (GO:0009812)3.99997371
95positive regulation of hemostasis (GO:1900048)3.99646314
96positive regulation of blood coagulation (GO:0030194)3.99646314
97positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.99581499
98complement activation, classical pathway (GO:0006958)3.98891175
99arginine metabolic process (GO:0006525)3.98185510
100serine family amino acid biosynthetic process (GO:0009070)3.97532220
101cellular glucuronidation (GO:0052695)3.96488440
102cellular modified amino acid catabolic process (GO:0042219)3.95803395
103complement activation (GO:0006956)3.93487860
104opsonization (GO:0008228)3.90369138
105heme transport (GO:0015886)3.87293745
106plasma lipoprotein particle organization (GO:0071827)3.87077058
107ketone body metabolic process (GO:1902224)3.86917007
108phospholipid homeostasis (GO:0055091)3.86135608
109positive regulation of lipid catabolic process (GO:0050996)3.84702205
110* acute inflammatory response (GO:0002526)3.83628861
111negative regulation of lipase activity (GO:0060192)3.83485167
112cholesterol homeostasis (GO:0042632)3.79089701
113cofactor catabolic process (GO:0051187)3.77626425
114protein-lipid complex assembly (GO:0065005)3.76117788
115cytolysis (GO:0019835)3.74000293
116ethanol oxidation (GO:0006069)3.73196087
117regulation of plasminogen activation (GO:0010755)3.73139036
118sterol homeostasis (GO:0055092)3.72835144
119very-low-density lipoprotein particle assembly (GO:0034379)3.70547177
120positive regulation of coagulation (GO:0050820)3.67205159
121drug catabolic process (GO:0042737)3.65012382
122protein-lipid complex subunit organization (GO:0071825)3.63588592
123carboxylic acid catabolic process (GO:0046395)3.61818567
124organic acid catabolic process (GO:0016054)3.61818567
125regulation of cholesterol homeostasis (GO:2000188)3.60892045
126regulation of apoptotic cell clearance (GO:2000425)3.60048916
127negative regulation of humoral immune response (GO:0002921)3.60006895
128daunorubicin metabolic process (GO:0044597)3.59542920
129polyketide metabolic process (GO:0030638)3.59542920
130doxorubicin metabolic process (GO:0044598)3.59542920
131* regulation of acute inflammatory response (GO:0002673)3.59423805
132positive regulation of fatty acid biosynthetic process (GO:0045723)3.58100163
133steroid catabolic process (GO:0006706)3.55269904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.30038508
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13325758
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.96960267
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.44259624
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.33308126
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24541840
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89562003
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.14928755
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.08294107
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03746750
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00281735
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.2071730
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.94960489
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90004804
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.63807682
16CLOCK_20551151_ChIP-Seq_293T_Human1.51922743
17HTT_18923047_ChIP-ChIP_STHdh_Human1.50911783
18GATA1_22025678_ChIP-Seq_K562_Human1.48829089
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47242862
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.39989174
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26098714
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25316826
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25300845
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19880680
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17990749
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98511476
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97471602
28* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95235668
29* NFE2_27457419_Chip-Seq_LIVER_Mouse0.91968079
30* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91849818
31IRF8_22096565_ChIP-ChIP_GC-B_Human0.90389462
32* HNFA_21074721_ChIP-Seq_CACO-2_Human0.88894514
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88780446
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87712038
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85795473
36* PHF8_20622853_ChIP-Seq_HELA_Human0.85615031
37* GATA6_21074721_ChIP-Seq_CACO-2_Human0.82656982
38AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82332373
39RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82137502
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81925438
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81716617
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78534101
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77099614
44* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76478345
45GATA4_25053715_ChIP-Seq_YYC3_Human0.76284155
46SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75675950
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73032762
48RARA_24833708_ChIP-Seq_LIVER_Mouse0.72487808
49* NFYA_21822215_ChIP-Seq_K562_Human0.70508509
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70276151
51ZNF263_19887448_ChIP-Seq_K562_Human0.69838494
52* EZH2_27294783_Chip-Seq_NPCs_Mouse0.69329009
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69263644
54SOX2_21211035_ChIP-Seq_LN229_Human0.68848096
55KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68834713
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67574644
57ESR2_21235772_ChIP-Seq_MCF-7_Human0.67511301
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66097098
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65686883
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65542633
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65377006
62TP53_18474530_ChIP-ChIP_U2OS_Human0.64586475
63* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62392679
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62082912
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61938527
66NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61938527
67SRY_22984422_ChIP-ChIP_TESTIS_Rat0.61646832
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61431402
69RARB_24833708_ChIP-Seq_LIVER_Mouse0.61389836
70ER_23166858_ChIP-Seq_MCF-7_Human0.60649092
71* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.60381972
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59793350
73* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.59308607
74ETV2_25802403_ChIP-Seq_MESCs_Mouse0.58267836
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58104982
76TCF4_18268006_ChIP-ChIP_LS174T_Human0.57827968
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.57555357
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57487129
79SPI1_20517297_ChIP-Seq_HL60_Human0.57290030
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.56322200
81LXR_22292898_ChIP-Seq_THP-1_Human0.55745617
82CEBPB_22108803_ChIP-Seq_LS180_Human0.55542125
83RAC3_21632823_ChIP-Seq_H3396_Human0.55235230
84* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.55127953
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54618399
86EGR1_19032775_ChIP-ChIP_M12_Human0.54618239
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.54502938
88* ETV1_20927104_ChIP-Seq_GIST48_Human0.53674751
89* CRX_20693478_ChIP-Seq_RETINA_Mouse0.53507550
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53241984
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.52374643
92AR_20517297_ChIP-Seq_VCAP_Human0.52241196
93FOXA1_25552417_ChIP-Seq_VCAP_Human0.51889801
94MYC_19915707_ChIP-ChIP_AK7_Human0.51188955
95CTCF_20526341_ChIP-Seq_ESCs_Human0.51110406
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.50839967
97* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.50415306
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50211762
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50166785
100* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.50108222
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.49232717
102SA1_27219007_Chip-Seq_Bcells_Human0.48803959
103IGF1R_20145208_ChIP-Seq_DFB_Human0.48536047
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.48279019
105GATA1_19941826_ChIP-Seq_K562_Human0.48193955
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47905179
107* NFYB_21822215_ChIP-Seq_K562_Human0.47773110
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46227021
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.45871694
110P53_21459846_ChIP-Seq_SAOS-2_Human0.45480245
111CBP_21632823_ChIP-Seq_H3396_Human0.45439957
112TAF2_19829295_ChIP-Seq_ESCs_Human0.45030132
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.44813562
114ESET_19884257_ChIP-Seq_ESCs_Mouse0.44175196
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.43784690
116GATA2_19941826_ChIP-Seq_K562_Human0.43274207
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42940652
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42488300
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41590642
120MYC_27129775_Chip-Seq_CORNEA_Mouse0.40933309
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.40699756
122STAT1_17558387_ChIP-Seq_HELA_Human0.40635637
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.39942338
124STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39699092
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.39062070
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37832509
127BCAT_22108803_ChIP-Seq_LS180_Human0.37813341
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37675770
129GATA6_25053715_ChIP-Seq_YYC3_Human0.37427794
130E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.36420386
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.36329006
132FOXH1_21741376_ChIP-Seq_EPCs_Human0.35098520
133TAF15_26573619_Chip-Seq_HEK293_Human0.34907851
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.34835225
135LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34125806
136ERG_20517297_ChIP-Seq_VCAP_Human0.34111485
137SOX2_20726797_ChIP-Seq_SW620_Human0.34007022
138* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.33999574
139IRF1_19129219_ChIP-ChIP_H3396_Human0.33011273
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.32864413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.08501498
2MP0005360_urolithiasis7.59336826
3MP0005085_abnormal_gallbladder_physiolo6.35950457
4MP0005365_abnormal_bile_salt6.04081336
5MP0008875_abnormal_xenobiotic_pharmacok4.84925290
6MP0003806_abnormal_nucleotide_metabolis4.24420821
7MP0003252_abnormal_bile_duct3.80281279
8MP0010329_abnormal_lipoprotein_level3.67498212
9MP0009840_abnormal_foam_cell3.47322076
10MP0005083_abnormal_biliary_tract3.18748241
11MP0003191_abnormal_cellular_cholesterol2.96892150
12MP0003195_calcinosis2.87513569
13MP0005332_abnormal_amino_acid2.71820651
14MP0001666_abnormal_nutrient_absorption2.56930171
15MP0000609_abnormal_liver_physiology2.20741418
16MP0002118_abnormal_lipid_homeostasis2.11295617
17MP0004019_abnormal_vitamin_homeostasis2.08683379
18MP0002138_abnormal_hepatobiliary_system2.01582745
19MP0003868_abnormal_feces_composition1.84850425
20MP0005319_abnormal_enzyme/_coenzyme1.81792527
21MP0001764_abnormal_homeostasis1.63261239
22MP0009697_abnormal_copulation1.59217589
23MP0005584_abnormal_enzyme/coenzyme_acti1.57892176
24MP0003011_delayed_dark_adaptation1.54978535
25MP0003656_abnormal_erythrocyte_physiolo1.43854012
26MP0005451_abnormal_body_composition1.35923781
27MP0009643_abnormal_urine_homeostasis1.22620230
28MP0003705_abnormal_hypodermis_morpholog1.22050227
29MP0003186_abnormal_redox_activity1.21785680
30MP0000598_abnormal_liver_morphology1.21776075
31MP0010368_abnormal_lymphatic_system1.18457080
32MP0002254_reproductive_system_inflammat1.15324998
33MP0005647_abnormal_sex_gland1.11945874
34MP0009764_decreased_sensitivity_to1.11771409
35MP0009763_increased_sensitivity_to1.09716585
36MP0005636_abnormal_mineral_homeostasis0.97902923
37MP0008469_abnormal_protein_level0.95766143
38MP0009642_abnormal_blood_homeostasis0.90724302
39MP0005187_abnormal_penis_morphology0.86722318
40MP0005408_hypopigmentation0.83202718
41MP0009765_abnormal_xenobiotic_induced0.82140160
42MP0001915_intracranial_hemorrhage0.82133123
43MP0005376_homeostasis/metabolism_phenot0.81389255
44* MP0000604_amyloidosis0.80411101
45MP0005670_abnormal_white_adipose0.79642293
46MP0006036_abnormal_mitochondrial_physio0.77993483
47MP0002078_abnormal_glucose_homeostasis0.77566757
48MP0005220_abnormal_exocrine_pancreas0.76363635
49MP0005084_abnormal_gallbladder_morpholo0.75001740
50MP0002282_abnormal_trachea_morphology0.74162064
51MP0003690_abnormal_glial_cell0.73225688
52MP0005464_abnormal_platelet_physiology0.72782836
53MP0002876_abnormal_thyroid_physiology0.72089698
54MP0002971_abnormal_brown_adipose0.72085743
55MP0001661_extended_life_span0.71440688
56MP0009053_abnormal_anal_canal0.70954256
57MP0003879_abnormal_hair_cell0.70457358
58MP0000639_abnormal_adrenal_gland0.67442776
59MP0005334_abnormal_fat_pad0.65847223
60MP0005535_abnormal_body_temperature0.64850478
61MP0004130_abnormal_muscle_cell0.64229587
62MP0010386_abnormal_urinary_bladder0.63039726
63MP0003329_amyloid_beta_deposits0.61356280
64MP0005266_abnormal_metabolism0.61205502
65MP0001756_abnormal_urination0.58613126
66MP0005448_abnormal_energy_balance0.55834512
67MP0006035_abnormal_mitochondrial_morpho0.53602693
68MP0002089_abnormal_postnatal_growth/wei0.53455380
69MP0005058_abnormal_lysosome_morphology0.53452230
70MP0003436_decreased_susceptibility_to0.52685359
71MP0003724_increased_susceptibility_to0.50642061
72MP0002249_abnormal_larynx_morphology0.50495349
73MP0003075_altered_response_to0.47085031
74MP0003638_abnormal_response/metabolism_0.46855276
75MP0008873_increased_physiological_sensi0.45270382
76MP0002822_catalepsy0.44741364
77MP0005166_decreased_susceptibility_to0.44238721
78MP0003718_maternal_effect0.43747016
79MP0004883_abnormal_blood_vessel0.43567544
80MP0008874_decreased_physiological_sensi0.42601913
81MP0002928_abnormal_bile_duct0.42155620
82* MP0002136_abnormal_kidney_physiology0.41735301
83MP0002837_dystrophic_cardiac_calcinosis0.40613185
84MP0000579_abnormal_nail_morphology0.40079662
85* MP0005395_other_phenotype0.39305038
86MP0003953_abnormal_hormone_level0.39295985
87MP0000249_abnormal_blood_vessel0.37898258
88MP0005666_abnormal_adipose_tissue0.37852139
89MP0005248_abnormal_Harderian_gland0.36710990
90MP0004782_abnormal_surfactant_physiolog0.36455262
91MP0009384_cardiac_valve_regurgitation0.35929981
92MP0005164_abnormal_response_to0.35739908
93MP0002796_impaired_skin_barrier0.35253585
94MP0008872_abnormal_physiological_respon0.34163924
95MP0006082_CNS_inflammation0.33917197
96MP0002168_other_aberrant_phenotype0.33443366
97MP0000467_abnormal_esophagus_morphology0.33048470
98MP0001243_abnormal_dermal_layer0.32354468
99MP0009672_abnormal_birth_weight0.32261655
100MP0009115_abnormal_fat_cell0.31895026
101MP0004381_abnormal_hair_follicle0.31106115
102MP0002132_abnormal_respiratory_system0.30723088
103MP0005023_abnormal_wound_healing0.30708250
104MP0002090_abnormal_vision0.30581852
105* MP0001845_abnormal_inflammatory_respons0.30020839
106MP0000230_abnormal_systemic_arterial0.29956668
107MP0002332_abnormal_exercise_endurance0.29941519
108MP0002970_abnormal_white_adipose0.29198234
109MP0001881_abnormal_mammary_gland0.29117548
110MP0001853_heart_inflammation0.27462455
111MP0005167_abnormal_blood-brain_barrier0.27231900
112MP0003300_gastrointestinal_ulcer0.26805148
113* MP0009785_altered_susceptibility_to0.24943022
114MP0000920_abnormal_myelination0.23082292
115MP0001944_abnormal_pancreas_morphology0.22905278
116MP0000566_synostosis0.20900140
117MP0003959_abnormal_lean_body0.20864019
118MP0001851_eye_inflammation0.18388083
119MP0001545_abnormal_hematopoietic_system0.18255196
120MP0005397_hematopoietic_system_phenotyp0.18255196
121MP0002128_abnormal_blood_circulation0.16277913

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.68306956
2Intrahepatic cholestasis (HP:0001406)7.20440899
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.17462381
4Prolonged partial thromboplastin time (HP:0003645)6.87365612
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.44423191
6Hypobetalipoproteinemia (HP:0003563)6.34120399
7Xanthomatosis (HP:0000991)6.28669922
8Complement deficiency (HP:0004431)5.80424332
9Hyperlipoproteinemia (HP:0010980)5.73017056
10Abnormality of the common coagulation pathway (HP:0010990)5.20596945
11Joint hemorrhage (HP:0005261)5.11189736
12Hypolipoproteinemia (HP:0010981)4.97911369
13Hypoalphalipoproteinemia (HP:0003233)4.56893197
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.54811408
15Hyperammonemia (HP:0001987)4.52153831
16Epidermoid cyst (HP:0200040)4.34387115
17Abnormality of complement system (HP:0005339)4.25594297
18Hyperglycinemia (HP:0002154)4.21689495
19Abnormality of methionine metabolism (HP:0010901)4.20358790
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.16079720
21Spontaneous abortion (HP:0005268)4.13462137
22Ketosis (HP:0001946)4.13121341
23Fat malabsorption (HP:0002630)4.06612028
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06580136
25Abnormality of the intrinsic pathway (HP:0010989)3.99272279
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.93630144
27Hypoglycemic coma (HP:0001325)3.78977175
28Abnormality of pyrimidine metabolism (HP:0004353)3.66628681
29Abnormality of serine family amino acid metabolism (HP:0010894)3.65571130
30Abnormality of glycine metabolism (HP:0010895)3.65571130
31Hyperglycinuria (HP:0003108)3.60429083
32Conjugated hyperbilirubinemia (HP:0002908)3.58720355
33Hypercholesterolemia (HP:0003124)3.50567069
34Hyperbilirubinemia (HP:0002904)3.28679339
35Abnormality of fatty-acid metabolism (HP:0004359)3.21750673
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17964001
37Hypochromic microcytic anemia (HP:0004840)3.08846741
38Steatorrhea (HP:0002570)3.03430411
39Hepatocellular carcinoma (HP:0001402)3.03245821
40Systemic lupus erythematosus (HP:0002725)2.96669952
41Delayed CNS myelination (HP:0002188)2.93871079
42Abnormality of nucleobase metabolism (HP:0010932)2.92762124
43Abnormality of serum amino acid levels (HP:0003112)2.91523378
44Amyloidosis (HP:0011034)2.89938796
45Myocardial infarction (HP:0001658)2.88341652
46Ketoacidosis (HP:0001993)2.87342281
47Gingival bleeding (HP:0000225)2.86313247
48Glomerulonephritis (HP:0000099)2.78042333
49Metabolic acidosis (HP:0001942)2.70093032
50Skin nodule (HP:0200036)2.69620379
51Reduced antithrombin III activity (HP:0001976)2.66362493
52Osteomalacia (HP:0002749)2.64471794
53Purpura (HP:0000979)2.61903050
54Acanthocytosis (HP:0001927)2.60122143
55Recurrent gram-negative bacterial infections (HP:0005420)2.56552938
56Abnormality of purine metabolism (HP:0004352)2.55828846
57Lethargy (HP:0001254)2.51957722
58Vascular calcification (HP:0004934)2.48025356
59Thrombophlebitis (HP:0004418)2.47782995
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46413993
61Dicarboxylic aciduria (HP:0003215)2.46413993
62Abnormal gallbladder morphology (HP:0012437)2.42950008
63Gout (HP:0001997)2.42250138
64Spastic diplegia (HP:0001264)2.41513301
65Fair hair (HP:0002286)2.40286801
66Hypoglycemic seizures (HP:0002173)2.39622427
67Cholelithiasis (HP:0001081)2.39298043
68Menorrhagia (HP:0000132)2.33985582
69Cerebral edema (HP:0002181)2.33952494
70Mitral stenosis (HP:0001718)2.30851674
71Cholecystitis (HP:0001082)2.30050186
72Abnormal gallbladder physiology (HP:0012438)2.30050186
73Neonatal onset (HP:0003623)2.28932244
74Irritability (HP:0000737)2.28633735
75Esophageal varix (HP:0002040)2.24916935
76Malnutrition (HP:0004395)2.22062467
77Neonatal hypoglycemia (HP:0001998)2.21316205
78Cardiovascular calcification (HP:0011915)2.20058797
79Pancreatitis (HP:0001733)2.16903499
80Sensorimotor neuropathy (HP:0007141)2.12194579
81Enlarged kidneys (HP:0000105)2.10090871
82Elevated alkaline phosphatase (HP:0003155)2.07460006
83Poikilocytosis (HP:0004447)2.07088465
84Abnormality of iron homeostasis (HP:0011031)2.05031083
85Vomiting (HP:0002013)2.03665191
86Late onset (HP:0003584)2.02879262
87Increased serum ferritin (HP:0003281)2.02758404
88Hemorrhage of the eye (HP:0011885)1.99989104
89Hyperphosphaturia (HP:0003109)1.99243025
90Abnormality of transition element cation homeostasis (HP:0011030)1.99238357
91Abnormality of the Achilles tendon (HP:0005109)1.97597270
92Abnormality of the gallbladder (HP:0005264)1.97262388
93Brushfield spots (HP:0001088)1.96882093
94Generalized aminoaciduria (HP:0002909)1.96741882
95Hyperinsulinemic hypoglycemia (HP:0000825)1.93981159
96Opisthotonus (HP:0002179)1.93790546
97Arthropathy (HP:0003040)1.92585828
98Nephritis (HP:0000123)1.91983599
99Abnormality of alkaline phosphatase activity (HP:0004379)1.90441780
100Rickets (HP:0002748)1.84054220
101Gangrene (HP:0100758)1.82246371
102Glycosuria (HP:0003076)1.82193281
103Abnormality of urine glucose concentration (HP:0011016)1.82193281
104Joint swelling (HP:0001386)1.81748825
105Elevated hepatic transaminases (HP:0002910)1.80789021
106Abnormal delivery (HP:0001787)1.79711157
107Cerebral palsy (HP:0100021)1.79630153
108Hypophosphatemic rickets (HP:0004912)1.78858741
109Pulmonary embolism (HP:0002204)1.77764155
110Abnormality of vitamin metabolism (HP:0100508)1.77485827
111Status epilepticus (HP:0002133)1.76204951
112Abnormal cartilage morphology (HP:0002763)1.75185726
113Abnormal enzyme/coenzyme activity (HP:0012379)1.74844599
114Hypertriglyceridemia (HP:0002155)1.73690769
115Renal cortical cysts (HP:0000803)1.73343115
116Potter facies (HP:0002009)1.72836217
117Facial shape deformation (HP:0011334)1.72836217
118Atrioventricular block (HP:0001678)1.71796499
119Epistaxis (HP:0000421)1.68840248
120Generalized hypopigmentation of hair (HP:0011358)1.68301842
121Alkalosis (HP:0001948)1.68124668
122Hydroxyprolinuria (HP:0003080)1.67571276
123Abnormality of proline metabolism (HP:0010907)1.67571276
124Abnormal urine phosphate concentration (HP:0012599)1.60019827
125Bile duct proliferation (HP:0001408)1.55436405
126Abnormal biliary tract physiology (HP:0012439)1.55436405
127Increased serum pyruvate (HP:0003542)1.48124760
128Bifid scrotum (HP:0000048)1.46098733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.22984574
2LMTK26.78099053
3ERN15.27891646
4FGFR44.84304996
5SIK13.93287612
6ERBB43.04011635
7TAOK33.03416623
8INSRR2.76642503
9MAP4K22.46159956
10MAP2K42.33178537
11MST1R2.15625876
12NTRK32.08846139
13TRIB32.06309211
14MAPK111.99137083
15PKN21.95116485
16PIK3CA1.90719383
17PIK3CG1.86858713
18TYK21.84044444
19FLT31.65572026
20PTK61.61153626
21DAPK21.58316309
22LATS11.57919803
23PRKG21.55764237
24NEK91.48868255
25TNK21.45752165
26FER1.43615102
27ABL21.40252379
28KDR1.38262333
29JAK21.29109070
30EPHB11.26646376
31EPHA31.25559533
32FRK1.24749142
33FGFR21.20135108
34GRK61.16221758
35PRPF4B1.15281648
36PRKG11.13468246
37CAMKK21.13380771
38ERBB21.12630883
39MAP3K71.11509964
40JAK11.09681180
41MAP2K31.08252506
42TBK11.06454745
43PRKAA21.02860620
44PINK11.01804223
45MAPK40.96742489
46MAP3K100.93585202
47NLK0.91686733
48MET0.90828552
49ZAP700.89823416
50MAP3K20.88671971
51MAP3K110.88431961
52PDK20.86976659
53MAP3K30.86375893
54PRKCZ0.85938960
55EIF2AK30.85910601
56MYLK0.83503496
57MAP3K140.83147337
58PRKACA0.82975244
59MAPK120.80243775
60PRKACG0.79366391
61TIE10.79149309
62MAP3K120.77604602
63CDK60.75877287
64CAMK2G0.73191845
65MAPKAPK30.72583462
66RIPK10.72546454
67CSNK1D0.68806293
68STK38L0.67164056
69GSK3A0.66992940
70CSK0.63865234
71FGFR30.63434459
72DYRK1B0.62387581
73SCYL20.61795340
74TGFBR20.61525966
75CAMKK10.61158197
76PRKAA10.59381862
77CAMK1D0.57043994
78MAPK150.56702467
79PTK20.56002347
80MAP2K60.55635866
81CSF1R0.54725546
82MAPK70.54115146
83SGK30.52865573
84PDPK10.50995119
85IKBKE0.49979524
86PKN10.47653364
87SRC0.46905421
88PRKCQ0.46089931
89BLK0.45959523
90MAP2K10.45218949
91RPS6KA30.44909219
92MAP3K50.43790756
93RET0.43036485
94PRKCG0.42280860
95IRAK30.40705241
96GRK10.40186669
97EPHA40.39731837
98IGF1R0.38843496
99CSNK2A10.38339580
100CDK40.37946467
101TAOK20.37807609
102ICK0.37354487
103MAP3K10.37072367
104SGK20.36941877
105CSNK1G10.36929204
106AKT20.36857892
107EGFR0.36171891
108PBK0.35910849
109MAP3K60.35055275
110MTOR0.34161207
111MAP3K130.33643412
112PRKCE0.33233410
113BCR0.31818282
114IRAK10.31595910
115CAMK40.31485245
116NTRK10.29877096
117PDK10.29746772
118SGK10.29580933
119HIPK20.29498528
120SGK2230.27056882
121SGK4940.27056882
122LATS20.26347030
123PRKCA0.24781025
124BMX0.24633673
125PRKACB0.23540754
126PAK30.22170459
127MAP2K20.20697449
128ABL10.19802190
129MAPK30.17378728
130CSNK1E0.17027343
131MAP4K10.16232114
132PRKCB0.15661306

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.52520161
2Nitrogen metabolism_Homo sapiens_hsa009103.75961029
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49885051
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19761704
5Complement and coagulation cascades_Homo sapiens_hsa046103.16135333
6Arginine biosynthesis_Homo sapiens_hsa002203.10987587
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70081536
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68880947
9Tryptophan metabolism_Homo sapiens_hsa003802.60669874
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58881737
11Fatty acid degradation_Homo sapiens_hsa000712.48602070
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34091101
13Butanoate metabolism_Homo sapiens_hsa006502.12813870
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09930885
15Peroxisome_Homo sapiens_hsa041462.06454692
16Staphylococcus aureus infection_Homo sapiens_hsa051502.02185436
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00534450
18PPAR signaling pathway_Homo sapiens_hsa033201.89674453
19Propanoate metabolism_Homo sapiens_hsa006401.89117176
20Chemical carcinogenesis_Homo sapiens_hsa052041.87304867
21Fatty acid metabolism_Homo sapiens_hsa012121.84009327
22Histidine metabolism_Homo sapiens_hsa003401.82966985
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.82246365
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80129437
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75120158
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69691158
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.68062436
28beta-Alanine metabolism_Homo sapiens_hsa004101.65824335
29Selenocompound metabolism_Homo sapiens_hsa004501.60770269
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59123375
31Phenylalanine metabolism_Homo sapiens_hsa003601.57192849
32Retinol metabolism_Homo sapiens_hsa008301.56409070
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53559355
34Caffeine metabolism_Homo sapiens_hsa002321.52364184
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49896185
36Bile secretion_Homo sapiens_hsa049761.47654021
37Tyrosine metabolism_Homo sapiens_hsa003501.43705847
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.36057437
39Fatty acid elongation_Homo sapiens_hsa000621.34111574
40Pyruvate metabolism_Homo sapiens_hsa006201.32283606
41Sulfur metabolism_Homo sapiens_hsa009201.31174445
42Fat digestion and absorption_Homo sapiens_hsa049751.25934546
43Steroid biosynthesis_Homo sapiens_hsa001001.21205716
44Starch and sucrose metabolism_Homo sapiens_hsa005001.20621003
45Biosynthesis of amino acids_Homo sapiens_hsa012301.20589512
46Folate biosynthesis_Homo sapiens_hsa007901.20398693
47ABC transporters_Homo sapiens_hsa020101.17619851
48Carbon metabolism_Homo sapiens_hsa012001.13030042
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.02992958
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00716844
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00673927
52Vitamin B6 metabolism_Homo sapiens_hsa007500.96309036
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.96159376
54Sulfur relay system_Homo sapiens_hsa041220.95345643
55Vitamin digestion and absorption_Homo sapiens_hsa049770.93885895
56Arginine and proline metabolism_Homo sapiens_hsa003300.93379678
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89571113
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84822439
59Lysine degradation_Homo sapiens_hsa003100.77383151
60One carbon pool by folate_Homo sapiens_hsa006700.74760594
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67814514
62Glycerolipid metabolism_Homo sapiens_hsa005610.64449106
63Pentose phosphate pathway_Homo sapiens_hsa000300.63189921
64Glutathione metabolism_Homo sapiens_hsa004800.61389118
65Fatty acid biosynthesis_Homo sapiens_hsa000610.50679888
66Metabolic pathways_Homo sapiens_hsa011000.45330880
67Prion diseases_Homo sapiens_hsa050200.44045914
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43838366
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33135210
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27229212
71Galactose metabolism_Homo sapiens_hsa000520.25694398
72Fructose and mannose metabolism_Homo sapiens_hsa000510.25475021
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.24427561
74Insulin resistance_Homo sapiens_hsa049310.23895134
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20289515
76Linoleic acid metabolism_Homo sapiens_hsa005910.20237286
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.16896149
78Other glycan degradation_Homo sapiens_hsa005110.11371685
79Glucagon signaling pathway_Homo sapiens_hsa049220.10217074
80AMPK signaling pathway_Homo sapiens_hsa041520.02119940
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2707532
82Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2459609
83Ether lipid metabolism_Homo sapiens_hsa00565-0.2409931
84Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2295172
85Type II diabetes mellitus_Homo sapiens_hsa04930-0.2192714
86Amoebiasis_Homo sapiens_hsa05146-0.2184127
87Pertussis_Homo sapiens_hsa05133-0.2153869
88Bladder cancer_Homo sapiens_hsa05219-0.2132165
89N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1881388
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1773151
91Circadian rhythm_Homo sapiens_hsa04710-0.1718809
92Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1718756
93Regulation of autophagy_Homo sapiens_hsa04140-0.1673846
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1662526
95Renin-angiotensin system_Homo sapiens_hsa04614-0.1654141
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1595448
97Sphingolipid metabolism_Homo sapiens_hsa00600-0.1524221
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1454847
99Hepatitis C_Homo sapiens_hsa05160-0.1397127
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1290957
101Insulin signaling pathway_Homo sapiens_hsa04910-0.1146323
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0899288
103African trypanosomiasis_Homo sapiens_hsa05143-0.0852811
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0798001
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0677593
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0525681
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0382921
108Mineral absorption_Homo sapiens_hsa04978-0.0329966
109Serotonergic synapse_Homo sapiens_hsa04726-0.0295730

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »