APELA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/AKT pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.73603188
2regulation of posttranscriptional gene silencing (GO:0060147)5.73603188
3regulation of gene silencing by miRNA (GO:0060964)5.73603188
4L-serine metabolic process (GO:0006563)4.82653968
5maturation of SSU-rRNA (GO:0030490)4.55578740
6nuclear pore organization (GO:0006999)4.54111363
7negative regulation of translation, ncRNA-mediated (GO:0040033)4.36421567
8regulation of translation, ncRNA-mediated (GO:0045974)4.36421567
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.36421567
10nuclear pore complex assembly (GO:0051292)4.33814611
11mitotic metaphase plate congression (GO:0007080)4.30686366
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.24333504
13DNA replication-dependent nucleosome organization (GO:0034723)4.20864972
14DNA replication-dependent nucleosome assembly (GO:0006335)4.20864972
15folic acid-containing compound biosynthetic process (GO:0009396)4.17374268
16DNA replication initiation (GO:0006270)4.17091220
17regulation of mitotic spindle checkpoint (GO:1903504)4.16445727
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.16445727
19negative regulation of DNA-dependent DNA replication (GO:2000104)4.08493006
20protein complex localization (GO:0031503)4.06276048
21regulation of helicase activity (GO:0051095)4.05377639
22DNA strand elongation involved in DNA replication (GO:0006271)4.01703707
23ribosomal small subunit biogenesis (GO:0042274)4.00439394
24regulation of cell fate specification (GO:0042659)4.00008760
25chromatin remodeling at centromere (GO:0031055)3.97569738
26formation of translation preinitiation complex (GO:0001731)3.93481244
27establishment of integrated proviral latency (GO:0075713)3.87845404
28ribosome biogenesis (GO:0042254)3.83979129
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.83746944
30somatic hypermutation of immunoglobulin genes (GO:0016446)3.83746944
31nucleobase biosynthetic process (GO:0046112)3.83486692
32ribonucleoprotein complex biogenesis (GO:0022613)3.79065806
33viral transcription (GO:0019083)3.78925815
34DNA strand elongation (GO:0022616)3.78727077
35paraxial mesoderm development (GO:0048339)3.77506193
36CENP-A containing nucleosome assembly (GO:0034080)3.76336380
37translational termination (GO:0006415)3.75266688
38DNA double-strand break processing (GO:0000729)3.72716015
39lysine metabolic process (GO:0006553)3.72164164
40lysine catabolic process (GO:0006554)3.72164164
41DNA unwinding involved in DNA replication (GO:0006268)3.70341269
42IMP biosynthetic process (GO:0006188)3.69347283
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.69153988
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.69153988
45negative regulation of mitotic sister chromatid segregation (GO:0033048)3.69153988
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.69153988
47negative regulation of sister chromatid segregation (GO:0033046)3.69153988
48mitotic nuclear envelope disassembly (GO:0007077)3.68314485
49ribosomal large subunit biogenesis (GO:0042273)3.67702960
50ribosome assembly (GO:0042255)3.67569641
51telomere maintenance via semi-conservative replication (GO:0032201)3.67367769
52DNA replication checkpoint (GO:0000076)3.67037491
53metaphase plate congression (GO:0051310)3.61205955
54kinetochore organization (GO:0051383)3.60834216
55protein localization to kinetochore (GO:0034501)3.59966768
56purine nucleobase biosynthetic process (GO:0009113)3.57607395
57kinetochore assembly (GO:0051382)3.54553328
58spliceosomal snRNP assembly (GO:0000387)3.53263806
59negative regulation of androgen receptor signaling pathway (GO:0060766)3.53027744
60regulation of telomere maintenance via telomerase (GO:0032210)3.50691889
61ribosomal small subunit assembly (GO:0000028)3.47784044
62DNA replication-independent nucleosome organization (GO:0034724)3.47158624
63DNA replication-independent nucleosome assembly (GO:0006336)3.47158624
64L-alpha-amino acid transmembrane transport (GO:1902475)3.46753941
65negative regulation of DNA recombination (GO:0045910)3.43369630
66membrane disassembly (GO:0030397)3.40206844
67nuclear envelope disassembly (GO:0051081)3.40206844
68cell fate commitment involved in formation of primary germ layer (GO:0060795)3.38271350
69translational initiation (GO:0006413)3.38183364
70translational elongation (GO:0006414)3.38092561
71rRNA modification (GO:0000154)3.37065804
72lung-associated mesenchyme development (GO:0060484)3.36415396
73telomere maintenance via telomerase (GO:0007004)3.35542508
74spliceosomal complex assembly (GO:0000245)3.34907958
75negative regulation of telomerase activity (GO:0051974)3.34193687
76rRNA processing (GO:0006364)3.32606393
77pre-miRNA processing (GO:0031054)3.30329028
78double-strand break repair via nonhomologous end joining (GO:0006303)3.29223969
79non-recombinational repair (GO:0000726)3.29223969
80anterior/posterior axis specification, embryo (GO:0008595)3.27753861
81mitotic spindle checkpoint (GO:0071174)3.26642793
82histone exchange (GO:0043486)3.24477119
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.23854878
84pore complex assembly (GO:0046931)3.23613601
85female gonad development (GO:0008585)3.22786885
86spindle checkpoint (GO:0031577)3.22048836
87IMP metabolic process (GO:0046040)3.20918927
88rRNA metabolic process (GO:0016072)3.19877786
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19455897
90regulation of cell fate commitment (GO:0010453)3.18982223
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18156499
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18156499
93regulation of sister chromatid segregation (GO:0033045)3.17368995
94regulation of mitotic sister chromatid separation (GO:0010965)3.17368995
95regulation of mitotic sister chromatid segregation (GO:0033047)3.17368995
96telomere maintenance via recombination (GO:0000722)3.16725012
97nodal signaling pathway (GO:0038092)3.16020937
98serine family amino acid biosynthetic process (GO:0009070)3.15764448
99telomere maintenance via telomere lengthening (GO:0010833)3.15588327
100mitotic G2/M transition checkpoint (GO:0044818)3.13883004
101mitotic spindle assembly checkpoint (GO:0007094)3.13210414
102response to X-ray (GO:0010165)3.12323840
103DNA strand renaturation (GO:0000733)3.11574441
104histone H4-K12 acetylation (GO:0043983)3.10553360
105regulation of chromatin silencing (GO:0031935)3.09706726
106mitotic recombination (GO:0006312)3.09442887
107positive regulation of SMAD protein import into nucleus (GO:0060391)3.06540658
108spindle assembly checkpoint (GO:0071173)3.05730486
109regulation of gene silencing (GO:0060968)3.05721195
110pseudouridine synthesis (GO:0001522)3.05581534
111establishment of chromosome localization (GO:0051303)3.04749521
112cellular protein complex disassembly (GO:0043624)3.03238400
113regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03200263
114folic acid metabolic process (GO:0046655)3.01855066
115negative regulation of mitosis (GO:0045839)3.01517667
116ATP-dependent chromatin remodeling (GO:0043044)3.00188123
117determination of adult lifespan (GO:0008340)2.99910169
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.99663338
119DNA deamination (GO:0045006)2.99045951
120regulation of chromosome segregation (GO:0051983)2.98874772
121regulation of centrosome cycle (GO:0046605)2.98605443
122DNA duplex unwinding (GO:0032508)2.98431544
123DNA damage response, detection of DNA damage (GO:0042769)2.98371292
124transcription-coupled nucleotide-excision repair (GO:0006283)2.98286218
125DNA geometric change (GO:0032392)2.98251304
126protein localization to chromosome, centromeric region (GO:0071459)2.98173831
127negative regulation of gene silencing (GO:0060969)2.97678435
128establishment of apical/basal cell polarity (GO:0035089)2.97622321
129mitotic sister chromatid segregation (GO:0000070)2.96441310
130intra-S DNA damage checkpoint (GO:0031573)2.95880060
131transcription from RNA polymerase I promoter (GO:0006360)2.95686740
132ncRNA catabolic process (GO:0034661)2.94176395
133regulation of histone H3-K9 methylation (GO:0051570)2.92267939
134heterochromatin organization (GO:0070828)2.91600840
135single strand break repair (GO:0000012)2.89252882
136regulation of mitotic spindle organization (GO:0060236)2.87699760
137viral life cycle (GO:0019058)2.87484245
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86761423
139regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.86676970
140negative regulation of histone methylation (GO:0031061)2.85803195
141regulation of spindle organization (GO:0090224)2.85554633
142cellular protein complex localization (GO:0034629)2.85045447
143negative regulation of chromosome segregation (GO:0051985)2.84579671
144establishment of viral latency (GO:0019043)2.82728018
145histone arginine methylation (GO:0034969)2.82696881
146protein K6-linked ubiquitination (GO:0085020)2.82671848
147mismatch repair (GO:0006298)2.82221824
148maturation of 5.8S rRNA (GO:0000460)2.82102768
149regulation of centriole replication (GO:0046599)2.81900930
150regulation of SMAD protein import into nucleus (GO:0060390)2.81597126
151tetrahydrofolate metabolic process (GO:0046653)2.81044078
152cotranslational protein targeting to membrane (GO:0006613)2.79309763
153replication fork processing (GO:0031297)2.77123779
154RNA-dependent DNA replication (GO:0006278)2.76989109
155DNA ligation (GO:0006266)2.72944130
156proteasome assembly (GO:0043248)2.72659120
157negative regulation of nuclear division (GO:0051784)2.70554562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.02876277
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.50857769
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.51746042
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.35213918
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17477417
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.12111940
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.12111940
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.12111940
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98186182
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93591310
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.86001284
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.72236965
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72169067
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70955216
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70273263
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.66541291
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61396090
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.54438828
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.51342616
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.48518650
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44000403
22POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.37757477
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.37687062
24TCF3_18692474_ChIP-Seq_MEFs_Mouse2.35638026
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.32274777
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28306275
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22013665
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20273847
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16460686
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15697006
31GABP_17652178_ChIP-ChIP_JURKAT_Human2.15149010
32XRN2_22483619_ChIP-Seq_HELA_Human2.13851285
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10413473
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08714871
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06095451
36SOX2_18555785_ChIP-Seq_MESCs_Mouse2.05138135
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04272547
38ZNF274_21170338_ChIP-Seq_K562_Hela2.01236486
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00096031
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.98393584
41AR_21909140_ChIP-Seq_LNCAP_Human1.92133698
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91222558
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88580309
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87279337
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85683000
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.82097063
47SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81527800
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81318787
49EWS_26573619_Chip-Seq_HEK293_Human1.80066921
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.70341307
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70128909
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68190995
53TTF2_22483619_ChIP-Seq_HELA_Human1.66676416
54FUS_26573619_Chip-Seq_HEK293_Human1.66506164
55SOX2_18692474_ChIP-Seq_MEFs_Mouse1.62543572
56VDR_23849224_ChIP-Seq_CD4+_Human1.60803067
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54864986
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53759236
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.53358102
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52315933
61P300_19829295_ChIP-Seq_ESCs_Human1.52267141
62DCP1A_22483619_ChIP-Seq_HELA_Human1.52261719
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.51419054
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.49914677
65NANOG_18692474_ChIP-Seq_MEFs_Mouse1.45392193
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44772911
67OCT4_18692474_ChIP-Seq_MEFs_Mouse1.43907544
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43046794
69VDR_22108803_ChIP-Seq_LS180_Human1.42024126
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40868192
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39950399
72FOXP3_21729870_ChIP-Seq_TREG_Human1.38009465
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37035963
74SOX2_18692474_ChIP-Seq_MESCs_Mouse1.33129331
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32860429
76GABP_19822575_ChIP-Seq_HepG2_Human1.32625935
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31121277
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30802380
79IRF1_19129219_ChIP-ChIP_H3396_Human1.30044239
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.28442613
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27535385
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27284883
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.27074154
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26311479
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25567075
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25260794
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24439811
88ELK1_19687146_ChIP-ChIP_HELA_Human1.24016688
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.23063150
90NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20339019
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19794438
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19033681
93POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.18828539
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.17628868
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13191460
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12979615
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11739950
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09873918
99KDM5A_27292631_Chip-Seq_BREAST_Human1.08658667
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05949285
101GBX2_23144817_ChIP-Seq_PC3_Human1.05821978
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05441387
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.04111365
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03905845
105NANOG_16153702_ChIP-ChIP_HESCs_Human1.03424736
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01341491
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98399227
108TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98363112
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97762621
110IGF1R_20145208_ChIP-Seq_DFB_Human0.97682576
111KAP1_27257070_Chip-Seq_ESCs_Mouse0.95906563
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95489715
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95244330
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95244330
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94889438
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94840011
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90756936
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89926150
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89491445
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.89401516
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88806883
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.88664330
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88013663
124CIITA_25753668_ChIP-Seq_RAJI_Human0.87748827
125NANOG_16518401_ChIP-PET_MESCs_Mouse0.87313491
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86940149
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85838852
128MYC_18940864_ChIP-ChIP_HL60_Human0.84576841
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84506295
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82561124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.31365778
2MP0003693_abnormal_embryo_hatching4.16360115
3MP0004957_abnormal_blastocyst_morpholog4.15089480
4MP0004133_heterotaxia3.80583942
5MP0003111_abnormal_nucleus_morphology3.61704237
6MP0003806_abnormal_nucleotide_metabolis3.56687919
7MP0010094_abnormal_chromosome_stability3.49972358
8MP0008057_abnormal_DNA_replication3.32126661
9MP0003123_paternal_imprinting3.30985175
10MP0003077_abnormal_cell_cycle3.17012589
11MP0008058_abnormal_DNA_repair2.74017769
12MP0008932_abnormal_embryonic_tissue2.57904298
13MP0006292_abnormal_olfactory_placode2.47570003
14MP0003941_abnormal_skin_development2.46503860
15MP0003890_abnormal_embryonic-extraembry2.27070846
16MP0001188_hyperpigmentation2.24448201
17MP0001730_embryonic_growth_arrest2.18929600
18MP0002653_abnormal_ependyma_morphology2.15087872
19MP0010352_gastrointestinal_tract_polyps2.15065990
20MP0003283_abnormal_digestive_organ2.13064594
21MP0001293_anophthalmia2.11637525
22MP0000350_abnormal_cell_proliferation2.08504890
23MP0010030_abnormal_orbit_morphology2.01671706
24MP0008007_abnormal_cellular_replicative1.99622281
25MP0003718_maternal_effect1.93424535
26MP0002085_abnormal_embryonic_tissue1.90743639
27MP0001672_abnormal_embryogenesis/_devel1.84594600
28MP0005380_embryogenesis_phenotype1.84594600
29MP0002084_abnormal_developmental_patter1.84521180
30MP0001697_abnormal_embryo_size1.82901091
31MP0003315_abnormal_perineum_morphology1.73779482
32MP0004043_abnormal_pH_regulation1.71571238
33MP0003119_abnormal_digestive_system1.70501061
34MP0004197_abnormal_fetal_growth/weight/1.68781819
35MP0003787_abnormal_imprinting1.60074075
36MP0003786_premature_aging1.57971901
37MP0002938_white_spotting1.56712231
38MP0003984_embryonic_growth_retardation1.55662705
39MP0003121_genomic_imprinting1.55222332
40MP0002088_abnormal_embryonic_growth/wei1.53565746
41MP0010307_abnormal_tumor_latency1.51327104
42MP0003136_yellow_coat_color1.48024186
43MP0000579_abnormal_nail_morphology1.47695574
44MP0002080_prenatal_lethality1.45464380
45MP0002736_abnormal_nociception_after1.43868010
46MP0002086_abnormal_extraembryonic_tissu1.43626559
47MP0009053_abnormal_anal_canal1.40599777
48MP0000537_abnormal_urethra_morphology1.40186752
49MP0001299_abnormal_eye_distance/1.39227915
50MP0000566_synostosis1.31161504
51MP0003567_abnormal_fetal_cardiomyocyte1.29538436
52MP0001286_abnormal_eye_development1.28647289
53MP0002102_abnormal_ear_morphology1.24597854
54MP0008877_abnormal_DNA_methylation1.23820924
55MP0009697_abnormal_copulation1.23644574
56MP0001485_abnormal_pinna_reflex1.23295991
57MP0002111_abnormal_tail_morphology1.22058486
58MP0006072_abnormal_retinal_apoptosis1.20507775
59MP0003186_abnormal_redox_activity1.19093785
60MP0000516_abnormal_urinary_system1.11728721
61MP0005367_renal/urinary_system_phenotyp1.11728721
62MP0006035_abnormal_mitochondrial_morpho1.10001394
63MP0005076_abnormal_cell_differentiation1.09850845
64MP0009379_abnormal_foot_pigmentation1.09082639
65MP0000313_abnormal_cell_death1.07872670
66MP0001177_atelectasis1.03718907
67MP0002233_abnormal_nose_morphology1.02641448
68MP0001145_abnormal_male_reproductive1.00931221
69MP0002210_abnormal_sex_determination0.99770364
70MP0003937_abnormal_limbs/digits/tail_de0.98199974
71MP0000049_abnormal_middle_ear0.97801167
72MP0000432_abnormal_head_morphology0.97539639
73MP0005395_other_phenotype0.97220195
74MP0002090_abnormal_vision0.97071322
75MP0000647_abnormal_sebaceous_gland0.94734474
76MP0001529_abnormal_vocalization0.92770925
77MP0002697_abnormal_eye_size0.92263634
78MP0005266_abnormal_metabolism0.92208304
79MP0003566_abnormal_cell_adhesion0.91752445
80MP0000631_abnormal_neuroendocrine_gland0.91648611
81MP0002249_abnormal_larynx_morphology0.91587853
82MP0003195_calcinosis0.90076800
83MP0003755_abnormal_palate_morphology0.89592319
84MP0003861_abnormal_nervous_system0.89408272
85MP0002160_abnormal_reproductive_system0.88865631
86MP0009703_decreased_birth_body0.88728585
87MP0002092_abnormal_eye_morphology0.86549552
88MP0003122_maternal_imprinting0.86439562
89MP0008789_abnormal_olfactory_epithelium0.85611895
90MP0000762_abnormal_tongue_morphology0.84598047
91MP0001984_abnormal_olfaction0.84300481
92MP0003938_abnormal_ear_development0.83745892
93MP0005332_abnormal_amino_acid0.83050357
94MP0004233_abnormal_muscle_weight0.83034233
95MP0005501_abnormal_skin_physiology0.81070786
96MP0001756_abnormal_urination0.80312329
97MP0000490_abnormal_crypts_of0.79997124
98MP0005377_hearing/vestibular/ear_phenot0.79559514
99MP0003878_abnormal_ear_physiology0.79559514
100MP0009672_abnormal_birth_weight0.77998548
101MP0000653_abnormal_sex_gland0.77533940
102MP0000750_abnormal_muscle_regeneration0.75992899
103MP0002019_abnormal_tumor_incidence0.75717642
104MP0003705_abnormal_hypodermis_morpholog0.75176814
105MP0003936_abnormal_reproductive_system0.74909355
106MP0002277_abnormal_respiratory_mucosa0.74810528
107MP0005389_reproductive_system_phenotype0.74610801
108MP0001968_abnormal_touch/_nociception0.74092481
109MP0000358_abnormal_cell_content/0.70902485
110MP0003942_abnormal_urinary_system0.70501037
111MP0005394_taste/olfaction_phenotype0.70045074
112MP0005499_abnormal_olfactory_system0.70045074
113MP0003935_abnormal_craniofacial_develop0.68882088
114MP0000428_abnormal_craniofacial_morphol0.68608348
115MP0004019_abnormal_vitamin_homeostasis0.68192309
116MP0002751_abnormal_autonomic_nervous0.68029900
117MP0000467_abnormal_esophagus_morphology0.67566143
118MP0002282_abnormal_trachea_morphology0.66989401
119MP0002116_abnormal_craniofacial_bone0.66284020
120MP0001929_abnormal_gametogenesis0.65554424
121MP0002796_impaired_skin_barrier0.63549975
122MP0005391_vision/eye_phenotype0.62638218
123MP0003137_abnormal_impulse_conducting0.61498882
124MP0005551_abnormal_eye_electrophysiolog0.58998462
125MP0003698_abnormal_male_reproductive0.58444007
126MP0001119_abnormal_female_reproductive0.58344764
127MP0001849_ear_inflammation0.57797931
128MP0008770_decreased_survivor_rate0.57578537
129MP0003646_muscle_fatigue0.55705551

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.26193897
2Ependymoma (HP:0002888)4.15946113
3Reticulocytopenia (HP:0001896)3.95363553
4Birth length less than 3rd percentile (HP:0003561)3.94236877
5Carpal bone hypoplasia (HP:0001498)3.82085970
6Abnormality of the labia minora (HP:0012880)3.78972728
7Renal salt wasting (HP:0000127)3.65091025
8Absent radius (HP:0003974)3.53130007
9Supernumerary spleens (HP:0009799)3.49901370
10Hepatoblastoma (HP:0002884)3.47006888
11Colon cancer (HP:0003003)3.43024005
12Medulloblastoma (HP:0002885)3.31820015
13Aplasia involving forearm bones (HP:0009822)3.30263374
14Absent forearm bone (HP:0003953)3.30263374
15Nephroblastoma (Wilms tumor) (HP:0002667)3.29865543
16Abnormality of abdominal situs (HP:0011620)3.24493540
17Abdominal situs inversus (HP:0003363)3.24493540
18Metabolic alkalosis (HP:0200114)3.16963749
19Embryonal renal neoplasm (HP:0011794)3.09927866
20Aplasia/hypoplasia of the humerus (HP:0006507)3.03657728
21Selective tooth agenesis (HP:0001592)3.02664770
22Rhabdomyosarcoma (HP:0002859)3.02176427
23Hypokalemic alkalosis (HP:0001949)2.98589769
24Bilateral microphthalmos (HP:0007633)2.93848061
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.91690114
26Hypomagnesemia (HP:0002917)2.91211501
27Abnormal number of incisors (HP:0011064)2.89679137
28Spastic diplegia (HP:0001264)2.85208055
29Astrocytoma (HP:0009592)2.83790854
30Abnormality of the astrocytes (HP:0100707)2.83790854
31Duplicated collecting system (HP:0000081)2.81973576
32Oral leukoplakia (HP:0002745)2.81092285
33Agnosia (HP:0010524)2.80689443
34Polyuria (HP:0000103)2.79749083
35Increased circulating renin level (HP:0000848)2.79143581
36Rectal fistula (HP:0100590)2.71978600
37Rectovaginal fistula (HP:0000143)2.71978600
38Choanal stenosis (HP:0000452)2.69537312
39Glioma (HP:0009733)2.66960542
40Hypoglycemic seizures (HP:0002173)2.65359153
41Maternal diabetes (HP:0009800)2.64762625
42Patellar aplasia (HP:0006443)2.63737867
43Short humerus (HP:0005792)2.63169739
44Absent septum pellucidum (HP:0001331)2.62259977
45Multiple enchondromatosis (HP:0005701)2.61803851
46Abnormality of chloride homeostasis (HP:0011422)2.61583948
47Hyperactive renin-angiotensin system (HP:0000841)2.58079435
48Esophageal atresia (HP:0002032)2.55712479
49Neoplasm of striated muscle (HP:0009728)2.55442807
50Abnormality of the septum pellucidum (HP:0007375)2.54319429
51Neoplasm of the oral cavity (HP:0100649)2.53434626
52Abnormality of homocysteine metabolism (HP:0010919)2.52499832
53Homocystinuria (HP:0002156)2.52499832
54Rib fusion (HP:0000902)2.50487451
55Abnormal urine output (HP:0012590)2.49483015
56Macrocytic anemia (HP:0001972)2.47211513
57Absent thumb (HP:0009777)2.47041253
58Chronic bronchitis (HP:0004469)2.46973808
59Hyperglycinemia (HP:0002154)2.46058089
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.45144712
61Aplasia/Hypoplasia of the patella (HP:0006498)2.43777932
62Abnormality of the anterior horn cell (HP:0006802)2.42729401
63Degeneration of anterior horn cells (HP:0002398)2.42729401
64Abnormality of magnesium homeostasis (HP:0004921)2.38050350
65Abnormality of serum amino acid levels (HP:0003112)2.37548530
66Pancreatic islet-cell hyperplasia (HP:0004510)2.35303740
67Horseshoe kidney (HP:0000085)2.34394442
68Optic nerve hypoplasia (HP:0000609)2.34161274
69Impulsivity (HP:0100710)2.33902833
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33774157
71Neoplasm of the adrenal cortex (HP:0100641)2.32701891
72Rough bone trabeculation (HP:0100670)2.32633166
73Chromsome breakage (HP:0040012)2.31282194
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31070140
75Abnormality of the renal collecting system (HP:0004742)2.27481770
76Intestinal fistula (HP:0100819)2.26373497
77Vaginal fistula (HP:0004320)2.25764788
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25603475
79Meckel diverticulum (HP:0002245)2.23107604
80Missing ribs (HP:0000921)2.22839761
81Spinal muscular atrophy (HP:0007269)2.22728221
82Anal stenosis (HP:0002025)2.22307770
83Aplasia/Hypoplasia of the hallux (HP:0008362)2.21156474
84Abnormality of glycine metabolism (HP:0010895)2.21102348
85Abnormality of serine family amino acid metabolism (HP:0010894)2.21102348
86Abnormality of the duodenum (HP:0002246)2.20667950
87Short hallux (HP:0010109)2.20348363
88Asplenia (HP:0001746)2.18558321
89Supernumerary bones of the axial skeleton (HP:0009144)2.17928000
90Abnormality of pyrimidine metabolism (HP:0004353)2.17091858
91Neoplasm of the colon (HP:0100273)2.16518677
92Duodenal stenosis (HP:0100867)2.15037097
93Small intestinal stenosis (HP:0012848)2.15037097
94Abnormality of the ileum (HP:0001549)2.14846136
95Ectopic kidney (HP:0000086)2.14160567
96Abnormality of chromosome stability (HP:0003220)2.13335660
97Hyperglycinuria (HP:0003108)2.12701505
98Hyponatremia (HP:0002902)2.12557532
99Metaphyseal cupping (HP:0003021)2.10165342
100Neoplasm of the pancreas (HP:0002894)2.10031586
101Stenosis of the external auditory canal (HP:0000402)2.09828213
102Bifid tongue (HP:0010297)2.09558204
103Hyperinsulinemic hypoglycemia (HP:0000825)2.09424484
104Aplasia/Hypoplasia of the spleen (HP:0010451)2.08719619
105Cerebral hypomyelination (HP:0006808)2.08078512
106Abnormality of renal excretion (HP:0011036)2.08042228
107Abnormality of methionine metabolism (HP:0010901)2.07547451
108Aplasia/Hypoplasia of the sternum (HP:0006714)2.07409550
109Aqueductal stenosis (HP:0002410)2.07093717
110Abnormality of sodium homeostasis (HP:0010931)2.06748498
111Aplasia/Hypoplasia of the uvula (HP:0010293)2.06563859
112Biliary tract neoplasm (HP:0100574)2.05739991
113Supernumerary ribs (HP:0005815)2.05271130
114Hyperaldosteronism (HP:0000859)2.05264240
115Cortical dysplasia (HP:0002539)2.01219988
116Absent eyebrow (HP:0002223)2.00568161
117Abnormal hair whorl (HP:0010721)2.00069609
118Fused cervical vertebrae (HP:0002949)1.99255835
119Hypoplastic female external genitalia (HP:0012815)1.99209389
120Breast aplasia (HP:0100783)1.98896968
121Neoplasm of the adrenal gland (HP:0100631)1.98880750
122Shawl scrotum (HP:0000049)1.98477829
123Gastrointestinal atresia (HP:0002589)1.98108862
124Intestinal atresia (HP:0011100)1.95913202
125Adenoma sebaceum (HP:0009720)1.95406194
126Angiofibromas (HP:0010615)1.95406194
127Triphalangeal thumb (HP:0001199)1.91761137
128Tracheoesophageal fistula (HP:0002575)1.91333683
129Gastrointestinal carcinoma (HP:0002672)1.91043818
130Malignant gastrointestinal tract tumors (HP:0006749)1.91043818
131High anterior hairline (HP:0009890)1.90839109
132Labial hypoplasia (HP:0000066)1.90333457
133Aplasia/Hypoplasia of the breasts (HP:0010311)1.89693443
134Acute lymphatic leukemia (HP:0006721)1.89349094
135Septo-optic dysplasia (HP:0100842)1.89326958
136Anophthalmia (HP:0000528)1.89218488
137Abolished electroretinogram (ERG) (HP:0000550)1.88304072
138Abnormality of cells of the erythroid lineage (HP:0012130)1.88102845
139Abnormality of the salivary glands (HP:0010286)1.88082580
140Breast carcinoma (HP:0003002)1.87366644
141Abnormality of the clitoris (HP:0000056)1.87177127
142Hemivertebrae (HP:0002937)1.86592337
143Premature graying of hair (HP:0002216)1.86591716
144Abnormality of the preputium (HP:0100587)1.86344233
145Clitoromegaly (HP:0000057)1.86113853
146Ovarian neoplasm (HP:0100615)1.84317981
147Dandy-Walker malformation (HP:0001305)1.84169714
148Embryonal neoplasm (HP:0002898)1.83522807
149Facial cleft (HP:0002006)1.83258480
150Abnormal lung lobation (HP:0002101)1.82762634
151Abnormality of the middle phalanges of the toes (HP:0010183)1.81908881
152Preaxial foot polydactyly (HP:0001841)1.81732182
153Cellular immunodeficiency (HP:0005374)1.81722890
154Abnormality of sulfur amino acid metabolism (HP:0004339)1.81696527
155Neoplasm of the small intestine (HP:0100833)1.80949496
156Uterine neoplasm (HP:0010784)1.80292759
157Sloping forehead (HP:0000340)1.74970959
158Pendular nystagmus (HP:0012043)1.73242924
159Hypoplasia of the pons (HP:0012110)1.71910889
160Protruding tongue (HP:0010808)1.70385908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.02419812
2BUB14.01405686
3WEE13.88176162
4CDC73.55226468
5TNIK3.51610002
6SRPK13.22146778
7NEK13.13213786
8EIF2AK12.98975679
9TTK2.79441751
10VRK22.74725301
11TAF12.60237117
12EPHA22.52257580
13NUAK12.23041565
14CDK192.20251283
15STK38L2.11188515
16CDK122.10438030
17PLK11.99704432
18TLK11.94424699
19CDK71.92255585
20PNCK1.90844340
21MKNK21.89088462
22RPS6KB21.87682509
23TRIM281.85096443
24MKNK11.84204337
25NME21.83757919
26TESK21.73223689
27NEK21.69180089
28PBK1.63127461
29CASK1.61415851
30NLK1.59095897
31PLK31.58533272
32OXSR11.57784266
33EIF2AK31.56786435
34FGFR21.55857439
35CHEK21.51118856
36VRK11.49797336
37PLK41.48073039
38ATR1.43251537
39AKT31.41664727
40MAP3K101.41395958
41TSSK61.41277336
42BCKDK1.40289308
43AURKB1.39588817
44AURKA1.39064553
45STK31.34966539
46INSRR1.32000376
47CHEK11.27419066
48PAK41.27207992
49MAP3K81.25953174
50DYRK31.25688191
51MST41.23167994
52ALK1.14735761
53PASK1.12009273
54STK161.09396831
55FRK1.07787772
56PRKCI1.07640305
57LATS21.01560990
58BMPR1B1.00554638
59CSNK1G11.00179473
60ACVR1B0.95128986
61CDK40.93985970
62CDK20.90608223
63ATM0.89463789
64STK240.88666021
65GRK10.88419433
66PDK20.88174664
67MAPKAPK30.87875953
68WNK40.85060279
69BRD40.82719785
70STK100.82186645
71BRAF0.80815507
72CSNK2A20.80476937
73STK40.79762336
74BRSK20.79489077
75DYRK20.79148285
76PDK30.78154461
77PDK40.78154461
78CAMK1G0.75910602
79ZAK0.75580200
80TIE10.70217044
81FLT30.69437980
82CSNK1E0.69295930
83CSNK1G20.69008783
84CSNK2A10.68552430
85MAP3K40.67347585
86CDK10.66369555
87MET0.66007937
88NEK60.65795756
89PIM10.65416887
90CAMK1D0.64417545
91EIF2AK20.61278252
92MAP4K20.60438665
93MTOR0.59961505
94SMG10.56426913
95BMX0.55938999
96LATS10.55370720
97PLK20.54435092
98CSNK1G30.53051247
99CDK60.51864735
100ERBB40.50693298
101MUSK0.50554662
102MAP3K110.48710807
103PAK10.47718885
104RPS6KA40.47701149
105MELK0.47612452
106ABL20.45740290
107BCR0.44015409
108TESK10.43998104
109FGFR10.42368763
110PRKCG0.42244067
111LRRK20.41537234
112CSNK1D0.41269691
113PRKCE0.40918552
114EGFR0.40493923
115AKT20.38338386
116BRSK10.38277103
117NME10.38108126
118SCYL20.37530098
119MAP3K90.36944025
120CDK30.34976743
121YES10.34932370
122PRKDC0.34643888
123DAPK10.34450783
124KSR10.33428612
125ADRBK20.33233497
126DYRK1A0.32770988
127CSNK1A10.32179699
128CSNK1A1L0.32171809
129CDC42BPA0.31329497
130MAPK140.29314145
131KDR0.28736504
132TGFBR10.25743514
133EPHB20.25297613
134GSK3B0.22205490
135PKN20.21407080
136ICK0.21295946
137RPS6KA50.21251863
138MAPK10.20938178
139TAOK20.20575128

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.43648929
2DNA replication_Homo sapiens_hsa030304.31978396
3Ribosome_Homo sapiens_hsa030103.93380327
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85671433
5One carbon pool by folate_Homo sapiens_hsa006703.43286356
6RNA polymerase_Homo sapiens_hsa030203.35146032
7Spliceosome_Homo sapiens_hsa030403.33006357
8RNA transport_Homo sapiens_hsa030133.11627965
9Proteasome_Homo sapiens_hsa030502.93060256
10Nucleotide excision repair_Homo sapiens_hsa034202.68199497
11Homologous recombination_Homo sapiens_hsa034402.66388405
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36120919
13Pyrimidine metabolism_Homo sapiens_hsa002402.35224153
14Base excision repair_Homo sapiens_hsa034102.31971958
15Fanconi anemia pathway_Homo sapiens_hsa034602.28317990
16Cell cycle_Homo sapiens_hsa041102.22349512
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87593247
18RNA degradation_Homo sapiens_hsa030181.76286519
19Basal transcription factors_Homo sapiens_hsa030221.74939758
20Non-homologous end-joining_Homo sapiens_hsa034501.71413439
21Vitamin B6 metabolism_Homo sapiens_hsa007501.70990821
22Protein export_Homo sapiens_hsa030601.70483218
23mRNA surveillance pathway_Homo sapiens_hsa030151.64105952
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.55073152
25Biosynthesis of amino acids_Homo sapiens_hsa012301.45025891
26Steroid biosynthesis_Homo sapiens_hsa001001.42573859
27p53 signaling pathway_Homo sapiens_hsa041151.35035795
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.26640900
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25099142
30Selenocompound metabolism_Homo sapiens_hsa004501.23648398
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22357362
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20144721
33Purine metabolism_Homo sapiens_hsa002301.18428522
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13572176
35Huntingtons disease_Homo sapiens_hsa050161.09311472
36Glutathione metabolism_Homo sapiens_hsa004801.09280820
37Basal cell carcinoma_Homo sapiens_hsa052171.06420079
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04822865
39Folate biosynthesis_Homo sapiens_hsa007901.04790619
40Carbon metabolism_Homo sapiens_hsa012000.99724442
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92709963
42Oxidative phosphorylation_Homo sapiens_hsa001900.88113336
43Hippo signaling pathway_Homo sapiens_hsa043900.87331997
44Parkinsons disease_Homo sapiens_hsa050120.86370301
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84006675
46Hedgehog signaling pathway_Homo sapiens_hsa043400.83958698
47Epstein-Barr virus infection_Homo sapiens_hsa051690.83374129
48Fatty acid elongation_Homo sapiens_hsa000620.82756384
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82545440
50Oocyte meiosis_Homo sapiens_hsa041140.81493811
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79195580
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74821672
53TGF-beta signaling pathway_Homo sapiens_hsa043500.73558152
54Fructose and mannose metabolism_Homo sapiens_hsa000510.71845719
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71713444
56Arginine and proline metabolism_Homo sapiens_hsa003300.70968206
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.69643643
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68832478
59Systemic lupus erythematosus_Homo sapiens_hsa053220.66050445
60Sulfur relay system_Homo sapiens_hsa041220.62394457
61MicroRNAs in cancer_Homo sapiens_hsa052060.60984660
62Retinol metabolism_Homo sapiens_hsa008300.60720175
63Pyruvate metabolism_Homo sapiens_hsa006200.58326366
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57169323
65Ether lipid metabolism_Homo sapiens_hsa005650.56987419
66Bladder cancer_Homo sapiens_hsa052190.55305360
67Lysine degradation_Homo sapiens_hsa003100.54927813
68Linoleic acid metabolism_Homo sapiens_hsa005910.52557072
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51285042
70Pentose phosphate pathway_Homo sapiens_hsa000300.51106727
71Thyroid cancer_Homo sapiens_hsa052160.50873782
72Viral carcinogenesis_Homo sapiens_hsa052030.50842903
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49596224
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46796852
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46322475
76Taste transduction_Homo sapiens_hsa047420.43897307
77Tight junction_Homo sapiens_hsa045300.43848493
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43665736
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43225856
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42457049
81Nicotine addiction_Homo sapiens_hsa050330.42426064
82Notch signaling pathway_Homo sapiens_hsa043300.41977361
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41618164
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.41200651
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40674357
86Metabolic pathways_Homo sapiens_hsa011000.40075305
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37582140
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.36714460
89Fatty acid degradation_Homo sapiens_hsa000710.36614982
90HTLV-I infection_Homo sapiens_hsa051660.36006723
91Fat digestion and absorption_Homo sapiens_hsa049750.35831797
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35714086
93Caffeine metabolism_Homo sapiens_hsa002320.35576838
94Propanoate metabolism_Homo sapiens_hsa006400.35337149
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34110123
96Wnt signaling pathway_Homo sapiens_hsa043100.32471470
97Fatty acid biosynthesis_Homo sapiens_hsa000610.31819617
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30279690
99Melanoma_Homo sapiens_hsa052180.29679110
100Small cell lung cancer_Homo sapiens_hsa052220.29164201
101Phototransduction_Homo sapiens_hsa047440.28511679
102Adherens junction_Homo sapiens_hsa045200.28188764
103Nitrogen metabolism_Homo sapiens_hsa009100.27970442
104Starch and sucrose metabolism_Homo sapiens_hsa005000.27572367
105Galactose metabolism_Homo sapiens_hsa000520.27403541
106Fatty acid metabolism_Homo sapiens_hsa012120.26852414
107Pathways in cancer_Homo sapiens_hsa052000.26600463
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26159293
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.24094156
110Alzheimers disease_Homo sapiens_hsa050100.23750955
111Arachidonic acid metabolism_Homo sapiens_hsa005900.22242161
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22047322
113Herpes simplex infection_Homo sapiens_hsa051680.21445396
114Cardiac muscle contraction_Homo sapiens_hsa042600.21341575
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20489398
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20376983
117Phenylalanine metabolism_Homo sapiens_hsa003600.16768134
118HIF-1 signaling pathway_Homo sapiens_hsa040660.16274852
119Colorectal cancer_Homo sapiens_hsa052100.14641996
120Peroxisome_Homo sapiens_hsa041460.14178193
121Vitamin digestion and absorption_Homo sapiens_hsa049770.13849854
122beta-Alanine metabolism_Homo sapiens_hsa004100.13429121
123Renin-angiotensin system_Homo sapiens_hsa046140.13376502
124Butanoate metabolism_Homo sapiens_hsa006500.13060003
125Arginine biosynthesis_Homo sapiens_hsa002200.13004770
126Antigen processing and presentation_Homo sapiens_hsa046120.12887133
127Protein digestion and absorption_Homo sapiens_hsa049740.12651720
128Tryptophan metabolism_Homo sapiens_hsa003800.10808163

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