APEX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.15105603
2ribosomal small subunit assembly (GO:0000028)4.92349384
3DNA strand elongation (GO:0022616)4.90424595
4maturation of SSU-rRNA (GO:0030490)4.89751183
5nucleobase biosynthetic process (GO:0046112)4.89407835
6DNA unwinding involved in DNA replication (GO:0006268)4.86234021
7DNA deamination (GO:0045006)4.78864851
8telomere maintenance via semi-conservative replication (GO:0032201)4.77613550
9formation of translation preinitiation complex (GO:0001731)4.76455558
10DNA replication initiation (GO:0006270)4.72196062
11purine nucleobase biosynthetic process (GO:0009113)4.63665164
12establishment of viral latency (GO:0019043)4.30328612
13viral transcription (GO:0019083)4.26587517
14translational termination (GO:0006415)4.21048830
15telomere maintenance via recombination (GO:0000722)4.20252239
16DNA replication checkpoint (GO:0000076)4.18026390
17ribosomal large subunit biogenesis (GO:0042273)4.16518322
18ribosomal small subunit biogenesis (GO:0042274)4.10727551
19ribosome assembly (GO:0042255)4.09694029
20ribosome biogenesis (GO:0042254)4.07990385
21ribonucleoprotein complex biogenesis (GO:0022613)4.05835202
22IMP biosynthetic process (GO:0006188)4.03749133
23mitotic recombination (GO:0006312)3.95831297
24translational elongation (GO:0006414)3.91516930
25mitotic metaphase plate congression (GO:0007080)3.89947300
26telomere maintenance via telomere lengthening (GO:0010833)3.87653168
27translational initiation (GO:0006413)3.87461518
28protein localization to kinetochore (GO:0034501)3.87402302
29spliceosomal snRNP assembly (GO:0000387)3.87236703
30DNA ligation (GO:0006266)3.81906849
31CENP-A containing nucleosome assembly (GO:0034080)3.76462342
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75935540
33pseudouridine synthesis (GO:0001522)3.75498708
34proteasome assembly (GO:0043248)3.71838840
35DNA replication-dependent nucleosome assembly (GO:0006335)3.71612490
36DNA replication-dependent nucleosome organization (GO:0034723)3.71612490
37chromatin remodeling at centromere (GO:0031055)3.70706528
38establishment of integrated proviral latency (GO:0075713)3.70033780
39rRNA processing (GO:0006364)3.68329475
40mitotic nuclear envelope disassembly (GO:0007077)3.65743284
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.64753123
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59908260
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58553877
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55605301
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.55548496
46rRNA metabolic process (GO:0016072)3.55237762
47L-serine metabolic process (GO:0006563)3.55145455
48folic acid-containing compound biosynthetic process (GO:0009396)3.53686258
49IMP metabolic process (GO:0046040)3.51571630
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50419967
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47258756
52DNA replication-independent nucleosome assembly (GO:0006336)3.46832418
53DNA replication-independent nucleosome organization (GO:0034724)3.46832418
54cotranslational protein targeting to membrane (GO:0006613)3.46770018
55chaperone-mediated protein transport (GO:0072321)3.46243320
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45239778
57protein targeting to ER (GO:0045047)3.44152748
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43287511
59transcription-coupled nucleotide-excision repair (GO:0006283)3.38664778
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.38008303
61metaphase plate congression (GO:0051310)3.37141586
62DNA damage response, detection of DNA damage (GO:0042769)3.36702322
63nuclear envelope disassembly (GO:0051081)3.36245882
64membrane disassembly (GO:0030397)3.36245882
65cellular protein complex disassembly (GO:0043624)3.35163897
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29886012
67negative regulation of ligase activity (GO:0051352)3.29886012
68viral life cycle (GO:0019058)3.29311298
69rRNA modification (GO:0000154)3.25697998
70protein localization to endoplasmic reticulum (GO:0070972)3.25239569
71protein localization to chromosome, centromeric region (GO:0071459)3.24897985
72kinetochore organization (GO:0051383)3.24700853
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24440226
74viral mRNA export from host cell nucleus (GO:0046784)3.23915839
75G1/S transition of mitotic cell cycle (GO:0000082)3.22232532
76cell cycle G1/S phase transition (GO:0044843)3.22232532
77regulation of mitochondrial translation (GO:0070129)3.20200027
78translation (GO:0006412)3.19561762
79spliceosomal complex assembly (GO:0000245)3.19409550
80termination of RNA polymerase III transcription (GO:0006386)3.19330771
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.19330771
82peptidyl-arginine omega-N-methylation (GO:0035247)3.18959326
83cellular component biogenesis (GO:0044085)3.16897746
84histone H2A acetylation (GO:0043968)3.15964668
85double-strand break repair via nonhomologous end joining (GO:0006303)3.15268107
86non-recombinational repair (GO:0000726)3.15268107
87energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13330476
88ATP synthesis coupled proton transport (GO:0015986)3.13330476
89histone exchange (GO:0043486)3.13166222
90negative regulation of mRNA processing (GO:0050686)3.12500818
91cullin deneddylation (GO:0010388)3.12244213
92kinetochore assembly (GO:0051382)3.11553431
93DNA topological change (GO:0006265)3.11272938
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.10944460
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10944460
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08939721
97protein complex disassembly (GO:0043241)3.08611380
98histone arginine methylation (GO:0034969)3.08579599
99oxidative phosphorylation (GO:0006119)3.08259060
100DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07979010
101RNA splicing, via transesterification reactions (GO:0000375)3.05223284
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04864222
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04864222
104RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.04823123
105mRNA splicing, via spliceosome (GO:0000398)3.04823123
106maturation of 5.8S rRNA (GO:0000460)3.04758273
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03882333
1087-methylguanosine mRNA capping (GO:0006370)3.03592137
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03119706
110signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02868879
111signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02868879
112signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02868879
113signal transduction involved in cell cycle checkpoint (GO:0072395)3.01905674
114protein deneddylation (GO:0000338)3.01811399
115regulation of helicase activity (GO:0051095)3.01239329
116regulation of cellular amino acid metabolic process (GO:0006521)3.00971524
117termination of RNA polymerase II transcription (GO:0006369)3.00971299
118signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00340893
119signal transduction involved in DNA damage checkpoint (GO:0072422)3.00340893
120mitotic sister chromatid segregation (GO:0000070)3.00229727
121nuclear-transcribed mRNA catabolic process (GO:0000956)2.99194391
122negative regulation of RNA splicing (GO:0033119)2.99113272
123establishment of chromosome localization (GO:0051303)2.98278241
124DNA double-strand break processing (GO:0000729)2.94477358
125* base-excision repair (GO:0006284)2.93140234
126tRNA aminoacylation for protein translation (GO:0006418)2.89793735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.15182639
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.74140834
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02629191
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47603290
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47194987
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.25754046
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24066720
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.17530440
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13383904
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12889844
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.12389652
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.07518635
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07469413
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85921577
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81521530
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80693003
17XRN2_22483619_ChIP-Seq_HELA_Human2.54288975
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46650111
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42872255
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42131070
21VDR_23849224_ChIP-Seq_CD4+_Human2.29085987
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19626463
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14538399
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07834301
25DCP1A_22483619_ChIP-Seq_HELA_Human2.06309637
26FOXP3_21729870_ChIP-Seq_TREG_Human2.05614236
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03175091
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03064334
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02922804
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01049956
31GABP_19822575_ChIP-Seq_HepG2_Human1.99643403
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97787044
33TTF2_22483619_ChIP-Seq_HELA_Human1.97699506
34AR_21909140_ChIP-Seq_LNCAP_Human1.93718145
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90440336
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86301254
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.84781845
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82598959
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.82552060
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78769096
41CIITA_25753668_ChIP-Seq_RAJI_Human1.71367952
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69353178
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68940433
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68625549
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64590290
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60919772
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60178344
48ELK1_19687146_ChIP-ChIP_HELA_Human1.59785552
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58709261
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53221563
51* SRF_21415370_ChIP-Seq_HL-1_Mouse1.52737493
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.49836713
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45781418
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43513418
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42120307
56KDM5A_27292631_Chip-Seq_BREAST_Human1.41285021
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41211087
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39927476
59MYC_22102868_ChIP-Seq_BL_Human1.36718745
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33511427
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26750538
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26546329
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26262449
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25331347
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25176258
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24600874
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.24451665
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23946619
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23672429
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23270656
71* SOX2_16153702_ChIP-ChIP_HESCs_Human1.16857324
72* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15328373
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.14980289
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14934957
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.13697999
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09637829
77* TFEB_21752829_ChIP-Seq_HELA_Human1.09359125
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08851560
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07969988
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07943024
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07401926
82MYC_18940864_ChIP-ChIP_HL60_Human1.00979972
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00598521
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00007644
85* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99124123
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98819044
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98519179
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.98345866
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98229423
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.96106367
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.95221357
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95184218
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94663670
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.94595770
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93000534
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91618701
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90599258
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89669795
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89489605
100OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89187698
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88148884
102* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84740945
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84629062
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84584716
105VDR_21846776_ChIP-Seq_THP-1_Human0.84305038
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84224872
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84224872
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84224872
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82055740
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82024658
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81662035
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81430194
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81322641
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80594390
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.80018534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.81686819
2MP0010094_abnormal_chromosome_stability4.87906668
3MP0004957_abnormal_blastocyst_morpholog4.86100183
4MP0003111_abnormal_nucleus_morphology4.55091832
5MP0003077_abnormal_cell_cycle4.23335569
6MP0008057_abnormal_DNA_replication4.11062840
7* MP0008058_abnormal_DNA_repair3.41907875
8MP0008007_abnormal_cellular_replicative3.10246989
9MP0008932_abnormal_embryonic_tissue2.97689482
10MP0003123_paternal_imprinting2.87882772
11MP0001730_embryonic_growth_arrest2.53356472
12MP0002396_abnormal_hematopoietic_system2.47241194
13MP0000350_abnormal_cell_proliferation2.31174787
14MP0008877_abnormal_DNA_methylation2.30074608
15MP0003786_premature_aging2.13451883
16MP0010030_abnormal_orbit_morphology2.10847960
17MP0010352_gastrointestinal_tract_polyps2.00316442
18MP0005499_abnormal_olfactory_system1.85957305
19MP0005394_taste/olfaction_phenotype1.85957305
20MP0003806_abnormal_nucleotide_metabolis1.83327892
21MP0001529_abnormal_vocalization1.80382403
22MP0001697_abnormal_embryo_size1.79821983
23* MP0005380_embryogenesis_phenotype1.72930898
24* MP0001672_abnormal_embryogenesis/_devel1.72930898
25MP0000490_abnormal_crypts_of1.69991261
26* MP0002080_prenatal_lethality1.68266538
27MP0003718_maternal_effect1.64447424
28* MP0002085_abnormal_embryonic_tissue1.56786873
29MP0010307_abnormal_tumor_latency1.56517394
30* MP0003984_embryonic_growth_retardation1.53187455
31* MP0002088_abnormal_embryonic_growth/wei1.49351426
32* MP0000313_abnormal_cell_death1.48845893
33MP0003315_abnormal_perineum_morphology1.48773652
34MP0001293_anophthalmia1.48495981
35MP0004133_heterotaxia1.46439804
36MP0006292_abnormal_olfactory_placode1.46257417
37MP0003567_abnormal_fetal_cardiomyocyte1.45762048
38MP0002084_abnormal_developmental_patter1.43896278
39MP0004808_abnormal_hematopoietic_stem1.41882131
40MP0003890_abnormal_embryonic-extraembry1.41831344
41MP0003121_genomic_imprinting1.39895719
42* MP0002019_abnormal_tumor_incidence1.39103114
43MP0004197_abnormal_fetal_growth/weight/1.37269030
44MP0009379_abnormal_foot_pigmentation1.32767347
45* MP0002086_abnormal_extraembryonic_tissu1.25505805
46MP0002233_abnormal_nose_morphology1.24712542
47MP0009333_abnormal_splenocyte_physiolog1.23320738
48MP0002210_abnormal_sex_determination1.22443611
49MP0002160_abnormal_reproductive_system1.18299317
50MP0002697_abnormal_eye_size1.18051046
51MP0001545_abnormal_hematopoietic_system1.12222270
52MP0005397_hematopoietic_system_phenotyp1.12222270
53MP0003119_abnormal_digestive_system1.12041502
54MP0000358_abnormal_cell_content/1.11367699
55MP0001346_abnormal_lacrimal_gland1.08031236
56MP0000537_abnormal_urethra_morphology1.08006728
57* MP0001145_abnormal_male_reproductive1.07114126
58MP0008995_early_reproductive_senescence1.03485994
59MP0000566_synostosis1.00147977
60MP0002938_white_spotting0.98709529
61MP0009053_abnormal_anal_canal0.97559636
62MP0002132_abnormal_respiratory_system0.97188318
63MP0009672_abnormal_birth_weight0.96121145
64MP0003763_abnormal_thymus_physiology0.95185859
65MP0001764_abnormal_homeostasis0.94962480
66MP0000703_abnormal_thymus_morphology0.94631740
67MP0002111_abnormal_tail_morphology0.94078625
68MP0005084_abnormal_gallbladder_morpholo0.91199340
69MP0003221_abnormal_cardiomyocyte_apopto0.91184603
70MP0006035_abnormal_mitochondrial_morpho0.90793321
71MP0006072_abnormal_retinal_apoptosis0.90587248
72MP0001188_hyperpigmentation0.90380746
73MP0002653_abnormal_ependyma_morphology0.89870379
74MP0003122_maternal_imprinting0.89862591
75* MP0000653_abnormal_sex_gland0.88438777
76MP0003941_abnormal_skin_development0.87941179
77MP0001929_abnormal_gametogenesis0.86249751
78MP0005389_reproductive_system_phenotype0.85438047
79MP0002722_abnormal_immune_system0.85358066
80MP0002234_abnormal_pharynx_morphology0.85305116
81MP0009697_abnormal_copulation0.83256040
82MP0000689_abnormal_spleen_morphology0.82947439
83MP0002398_abnormal_bone_marrow0.82886404
84MP0000516_abnormal_urinary_system0.82767770
85MP0005367_renal/urinary_system_phenotyp0.82767770
86MP0006036_abnormal_mitochondrial_physio0.82204394
87MP0000049_abnormal_middle_ear0.81335096
88MP0005501_abnormal_skin_physiology0.80087060
89MP0004147_increased_porphyrin_level0.79942716
90MP0001119_abnormal_female_reproductive0.79806307
91MP0008789_abnormal_olfactory_epithelium0.77173226
92* MP0003186_abnormal_redox_activity0.76901995
93MP0003943_abnormal_hepatobiliary_system0.76225130
94* MP0005384_cellular_phenotype0.76045143
95MP0003755_abnormal_palate_morphology0.75500661
96MP0006054_spinal_hemorrhage0.74691138
97MP0002102_abnormal_ear_morphology0.74609184
98MP0003385_abnormal_body_wall0.74497479
99MP0000858_altered_metastatic_potential0.74263991
100MP0000372_irregular_coat_pigmentation0.73432741
101MP0001286_abnormal_eye_development0.71619910
102MP0005266_abnormal_metabolism0.70953098
103MP0003937_abnormal_limbs/digits/tail_de0.70708421
104MP0000762_abnormal_tongue_morphology0.69394711
105MP0002429_abnormal_blood_cell0.69150889
106MP0003136_yellow_coat_color0.68779994
107MP0005075_abnormal_melanosome_morpholog0.68318513
108MP0002751_abnormal_autonomic_nervous0.66815294
109MP0002092_abnormal_eye_morphology0.65382536
110MP0001881_abnormal_mammary_gland0.60758019
111MP0003935_abnormal_craniofacial_develop0.60405796
112MP0009250_abnormal_appendicular_skeleto0.60254302
113MP0001915_intracranial_hemorrhage0.59641840
114MP0003942_abnormal_urinary_system0.58842123
115MP0001849_ear_inflammation0.58759333
116* MP0005621_abnormal_cell_physiology0.58343607
117MP0003698_abnormal_male_reproductive0.57304949
118MP0000477_abnormal_intestine_morphology0.57128373
119MP0009703_decreased_birth_body0.57127860
120MP0002095_abnormal_skin_pigmentation0.56677996
121MP0000428_abnormal_craniofacial_morphol0.56627600
122MP0003011_delayed_dark_adaptation0.56134393
123MP0001919_abnormal_reproductive_system0.55308237
124MP0005076_abnormal_cell_differentiation0.53936503
125MP0000750_abnormal_muscle_regeneration0.52847012
126MP0002075_abnormal_coat/hair_pigmentati0.52724364
127MP0003938_abnormal_ear_development0.51565566
128MP0002114_abnormal_axial_skeleton0.51191433
129MP0003861_abnormal_nervous_system0.50356898
130MP0005023_abnormal_wound_healing0.49872971

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.17456496
2Abnormality of cells of the erythroid lineage (HP:0012130)4.77776456
3Reticulocytopenia (HP:0001896)4.76595765
4Abnormal number of erythroid precursors (HP:0012131)4.55963075
5Oral leukoplakia (HP:0002745)4.08126951
6Colon cancer (HP:0003003)3.89511995
7Breast hypoplasia (HP:0003187)3.89066613
8Aplastic anemia (HP:0001915)3.74530705
9Selective tooth agenesis (HP:0001592)3.67165468
10Degeneration of anterior horn cells (HP:0002398)3.44022693
11Abnormality of the anterior horn cell (HP:0006802)3.44022693
12Patellar aplasia (HP:0006443)3.33433785
13Rough bone trabeculation (HP:0100670)3.28263749
14Macrocytic anemia (HP:0001972)3.23732055
15Acute necrotizing encephalopathy (HP:0006965)3.20488037
16Medulloblastoma (HP:0002885)3.19591270
17Aplasia/Hypoplasia of the patella (HP:0006498)3.16784363
18Acute encephalopathy (HP:0006846)3.16353374
19Carpal bone hypoplasia (HP:0001498)3.10516566
20Increased hepatocellular lipid droplets (HP:0006565)3.09012625
21Cerebral hypomyelination (HP:0006808)3.03431605
22Chromsome breakage (HP:0040012)3.00710649
23Abnormal mitochondria in muscle tissue (HP:0008316)2.98552677
24Pallor (HP:0000980)2.95439813
25Ependymoma (HP:0002888)2.92306776
26Agnosia (HP:0010524)2.88047240
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82606889
28Mitochondrial inheritance (HP:0001427)2.81478399
29Meckel diverticulum (HP:0002245)2.79713094
30Absent thumb (HP:0009777)2.79671869
3111 pairs of ribs (HP:0000878)2.77327608
32Multiple enchondromatosis (HP:0005701)2.72642095
33Microretrognathia (HP:0000308)2.72336900
34Abnormality of the ileum (HP:0001549)2.71885810
35Abnormality of the preputium (HP:0100587)2.71764819
36Lipid accumulation in hepatocytes (HP:0006561)2.71655938
37Abnormal number of incisors (HP:0011064)2.70328475
38Premature graying of hair (HP:0002216)2.64663787
39Hyperglycinemia (HP:0002154)2.62058925
40Trismus (HP:0000211)2.58910566
41Abnormality of chromosome stability (HP:0003220)2.57192259
42Neoplasm of the pancreas (HP:0002894)2.56506671
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54876546
44Cerebral edema (HP:0002181)2.52977280
45Absent radius (HP:0003974)2.52190107
46Cellular immunodeficiency (HP:0005374)2.50922049
47Hepatic necrosis (HP:0002605)2.48286922
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.48115545
49Increased serum pyruvate (HP:0003542)2.45616411
50Abnormality of glycolysis (HP:0004366)2.45616411
51Reduced antithrombin III activity (HP:0001976)2.43009447
52Abnormal lung lobation (HP:0002101)2.40400273
53Nephroblastoma (Wilms tumor) (HP:0002667)2.38380271
54Myelodysplasia (HP:0002863)2.37703388
55Progressive macrocephaly (HP:0004481)2.35842092
56Absent forearm bone (HP:0003953)2.35649654
57Aplasia involving forearm bones (HP:0009822)2.35649654
58Bone marrow hypocellularity (HP:0005528)2.35368313
59Impulsivity (HP:0100710)2.34656919
60Supernumerary spleens (HP:0009799)2.33130403
61Horseshoe kidney (HP:0000085)2.32265922
62Type I transferrin isoform profile (HP:0003642)2.31200547
63Hyperglycinuria (HP:0003108)2.30264456
64Rhabdomyosarcoma (HP:0002859)2.29084542
65Abnormal trabecular bone morphology (HP:0100671)2.27140993
66Abnormal protein N-linked glycosylation (HP:0012347)2.24640738
67Abnormal protein glycosylation (HP:0012346)2.24640738
68Abnormal glycosylation (HP:0012345)2.24640738
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24640738
70Premature ovarian failure (HP:0008209)2.24056687
71Lactic acidosis (HP:0003128)2.23755723
72Small intestinal stenosis (HP:0012848)2.22610567
73Duodenal stenosis (HP:0100867)2.22610567
74Cleft eyelid (HP:0000625)2.22347653
75Increased serum lactate (HP:0002151)2.20571422
76Abnormality of serine family amino acid metabolism (HP:0010894)2.20178074
77Abnormality of glycine metabolism (HP:0010895)2.20178074
78Embryonal renal neoplasm (HP:0011794)2.20112668
79Atresia of the external auditory canal (HP:0000413)2.19651063
80Pancytopenia (HP:0001876)2.18879149
81Glossoptosis (HP:0000162)2.18041045
82Thrombocytosis (HP:0001894)2.17588101
83Tracheoesophageal fistula (HP:0002575)2.17550350
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17454880
85Renal Fanconi syndrome (HP:0001994)2.15921360
86Atrophy/Degeneration involving motor neurons (HP:0007373)2.14600255
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13462953
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13462953
89Abnormality of serum amino acid levels (HP:0003112)2.12078462
90Abnormality of the labia minora (HP:0012880)2.10937624
91Triphalangeal thumb (HP:0001199)2.08824613
92Abnormality of pyrimidine metabolism (HP:0004353)2.06661422
93Missing ribs (HP:0000921)2.05115657
94Secondary amenorrhea (HP:0000869)2.04382080
95Abnormality of methionine metabolism (HP:0010901)2.04368287
96Basal cell carcinoma (HP:0002671)2.04282202
97Sloping forehead (HP:0000340)2.02662542
98Respiratory difficulties (HP:0002880)2.01614727
99Hypoplasia of the radius (HP:0002984)1.99868514
100Facial cleft (HP:0002006)1.98668921
101Exercise intolerance (HP:0003546)1.98170306
102Megaloblastic anemia (HP:0001889)1.97824783
103Neoplasm of the adrenal gland (HP:0100631)1.97619090
104Squamous cell carcinoma (HP:0002860)1.95250934
105Slender long bone (HP:0003100)1.93045198
106Hypoplastic pelvis (HP:0008839)1.92278791
107Increased intramyocellular lipid droplets (HP:0012240)1.91769181
108Optic nerve coloboma (HP:0000588)1.91364910
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.90605633
110Muscle fiber atrophy (HP:0100295)1.90573834
111Abnormality of the duodenum (HP:0002246)1.89869832
112Cortical dysplasia (HP:0002539)1.89626004
113Increased nuchal translucency (HP:0010880)1.89610850
114Increased CSF lactate (HP:0002490)1.85060206
115Proximal placement of thumb (HP:0009623)1.84026519
116CNS hypomyelination (HP:0003429)1.83012501
117Neoplasm of the colon (HP:0100273)1.82514261
118Hepatocellular necrosis (HP:0001404)1.79421310
119Postnatal microcephaly (HP:0005484)1.77247480
120Methylmalonic acidemia (HP:0002912)1.76934495
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76926153
122Lymphoma (HP:0002665)1.76562887
123Type 2 muscle fiber atrophy (HP:0003554)1.76494952
124Abnormal gallbladder physiology (HP:0012438)1.74315328
125Cholecystitis (HP:0001082)1.74315328
126Deviation of the thumb (HP:0009603)1.73829198
127Duplicated collecting system (HP:0000081)1.73726970
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73496018
129Sparse eyelashes (HP:0000653)1.73117188
130Progressive muscle weakness (HP:0003323)1.72997154
131Spastic diplegia (HP:0001264)1.72900888
132Short thumb (HP:0009778)1.72642374
133Microvesicular hepatic steatosis (HP:0001414)1.72575540
134Amaurosis fugax (HP:0100576)1.72252559
135Bifid tongue (HP:0010297)1.71502624
136Stenosis of the external auditory canal (HP:0000402)1.70510948
137Abnormality of the umbilical cord (HP:0010881)1.69488382
138Bilateral microphthalmos (HP:0007633)1.69473732
139Leukodystrophy (HP:0002415)1.67886679
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66392029
141Respiratory failure (HP:0002878)1.66076454
142Abnormality of the parathyroid morphology (HP:0011766)1.65213472
143Shoulder girdle muscle weakness (HP:0003547)1.64428616
144Abnormality of the fetal cardiovascular system (HP:0010948)1.63770928
145Single umbilical artery (HP:0001195)1.63770928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.83145454
2BUB14.97903988
3WEE14.40689355
4CDC73.85713016
5EIF2AK13.47373559
6STK163.06028917
7TSSK62.84245874
8NME22.60510801
9SRPK12.60237765
10EIF2AK32.54053515
11ACVR1B2.40343282
12TAF12.38021148
13NEK22.18572967
14NEK12.15906845
15VRK12.11888248
16TTK2.03865882
17PASK2.01216418
18PLK41.98757876
19PLK11.94784157
20NUAK11.91374171
21MKNK11.89894637
22TESK21.87614191
23DYRK31.85673259
24CDK71.85251538
25BRSK21.84137875
26ATR1.70472787
27SMG11.69931972
28PLK31.63296009
29AURKB1.55211248
30RPS6KB21.54765076
31TGFBR11.52704952
32TLK11.45201870
33PIM21.38524763
34RPS6KA41.36807024
35AURKA1.36140674
36MST41.34621930
37BRSK11.33549684
38MKNK21.30976904
39CCNB11.30731048
40PAK41.30352313
41TRIM281.25113432
42CHEK21.19736145
43MAP3K81.18384525
44CDK41.14461350
45SCYL21.13789864
46EPHA21.10375811
47CHEK11.09078011
48MAP4K21.06814788
49EEF2K1.04919221
50PDK20.93317993
51BCKDK0.92316583
52TNIK0.88387131
53CDK80.86801326
54ZAK0.82636171
55KDR0.81134590
56TAOK20.81027523
57TESK10.78912756
58* CSNK2A20.77744940
59CDK20.75812120
60CDK90.75536939
61EIF2AK20.75480566
62STK40.75233976
63BRAF0.74852696
64* CSNK2A10.74164309
65PAK10.72331811
66NME10.72009121
67PNCK0.71719434
68ATM0.71063696
69PIM10.67198218
70MAP3K110.66198347
71STK100.65466828
72DAPK10.63356652
73CDK120.63355181
74PRKCI0.62597032
75CSNK1G10.62304553
76PBK0.61997360
77FLT30.61667965
78DYRK20.60182214
79MAPKAPK30.60179380
80MAP3K100.59890320
81BMPR1B0.56748097
82CDK10.55474709
83LRRK20.54949264
84ALK0.54430377
85WNK30.52679182
86BRD40.50556230
87MAP2K30.48073556
88RPS6KA50.44288089
89ERBB40.44166157
90ILK0.44079626
91AKT20.43883509
92MAP4K10.43125490
93CSNK1A1L0.42439864
94CDK30.42200212
95MAPKAPK50.41479638
96CDK190.41112535
97MUSK0.40665618
98CLK10.39113248
99LIMK10.38333934
100BTK0.38004228
101CDK60.37914635
102CSNK1G20.37529972
103CSNK1E0.32928280
104YES10.32574581
105ABL20.32130213
106CDK180.30592066
107CDK140.29811651
108CDK150.29265305
109BCR0.28456011
110PKN20.27383909
111MELK0.27380679
112CSNK1G30.27367810
113TEC0.27316513
114RAF10.25220741
115LATS20.24180452
116ERBB30.23485749
117PAK20.22708643
118PRKDC0.22524565
119ARAF0.22125046
120FGFR10.21328423
121CDK11A0.21265519
122PRKD30.21231636
123GRK60.20561029
124RPS6KC10.20454263
125RPS6KL10.20454263
126DAPK30.20182551

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.20304893
2Mismatch repair_Homo sapiens_hsa034304.42047261
3Ribosome_Homo sapiens_hsa030104.02284127
4Proteasome_Homo sapiens_hsa030503.97796522
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76769499
6RNA polymerase_Homo sapiens_hsa030203.58280115
7Spliceosome_Homo sapiens_hsa030403.50902624
8RNA transport_Homo sapiens_hsa030133.09122388
9Homologous recombination_Homo sapiens_hsa034402.94347884
10Nucleotide excision repair_Homo sapiens_hsa034202.93511245
11* Base excision repair_Homo sapiens_hsa034102.92193080
12Pyrimidine metabolism_Homo sapiens_hsa002402.72791921
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66372039
14One carbon pool by folate_Homo sapiens_hsa006702.59869848
15Cell cycle_Homo sapiens_hsa041102.50481334
16Fanconi anemia pathway_Homo sapiens_hsa034601.97516436
17Non-homologous end-joining_Homo sapiens_hsa034501.92512595
18RNA degradation_Homo sapiens_hsa030181.85988696
19Basal transcription factors_Homo sapiens_hsa030221.82478857
20Fatty acid elongation_Homo sapiens_hsa000621.52179332
21mRNA surveillance pathway_Homo sapiens_hsa030151.51751994
22Purine metabolism_Homo sapiens_hsa002301.47275803
23Propanoate metabolism_Homo sapiens_hsa006401.40582531
24p53 signaling pathway_Homo sapiens_hsa041151.38748521
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21098008
26Epstein-Barr virus infection_Homo sapiens_hsa051691.15856057
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.12142237
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11894694
29Biosynthesis of amino acids_Homo sapiens_hsa012301.08424380
30Steroid biosynthesis_Homo sapiens_hsa001001.06260456
31Systemic lupus erythematosus_Homo sapiens_hsa053221.02606052
32Folate biosynthesis_Homo sapiens_hsa007900.96939032
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94618012
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.92102101
35Huntingtons disease_Homo sapiens_hsa050160.90255835
36Parkinsons disease_Homo sapiens_hsa050120.89093158
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88606692
38Pentose phosphate pathway_Homo sapiens_hsa000300.86789193
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86157351
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.85564420
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84972360
42Oocyte meiosis_Homo sapiens_hsa041140.81472741
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79479691
44Protein export_Homo sapiens_hsa030600.79077291
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75211505
46Sulfur relay system_Homo sapiens_hsa041220.73625379
47Selenocompound metabolism_Homo sapiens_hsa004500.73009020
48Viral carcinogenesis_Homo sapiens_hsa052030.72528476
49Oxidative phosphorylation_Homo sapiens_hsa001900.69727531
50Herpes simplex infection_Homo sapiens_hsa051680.69448730
51Carbon metabolism_Homo sapiens_hsa012000.69028268
52Antigen processing and presentation_Homo sapiens_hsa046120.67869856
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65727902
54Glutathione metabolism_Homo sapiens_hsa004800.64218207
55Fatty acid metabolism_Homo sapiens_hsa012120.63536823
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61967126
57Thyroid cancer_Homo sapiens_hsa052160.60296946
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57773094
59Vitamin B6 metabolism_Homo sapiens_hsa007500.56795877
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56361433
61HTLV-I infection_Homo sapiens_hsa051660.55646593
62Peroxisome_Homo sapiens_hsa041460.54535628
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53500312
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51397716
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50255939
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49597135
67N-Glycan biosynthesis_Homo sapiens_hsa005100.49253942
68Lysine degradation_Homo sapiens_hsa003100.47985298
69Legionellosis_Homo sapiens_hsa051340.47804801
70Butanoate metabolism_Homo sapiens_hsa006500.45956593
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45907078
72Fructose and mannose metabolism_Homo sapiens_hsa000510.45311212
73Sulfur metabolism_Homo sapiens_hsa009200.41398672
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41060749
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38977452
76Fatty acid degradation_Homo sapiens_hsa000710.35929225
77Basal cell carcinoma_Homo sapiens_hsa052170.34203253
78Alcoholism_Homo sapiens_hsa050340.34191062
79Vitamin digestion and absorption_Homo sapiens_hsa049770.33305665
80Cardiac muscle contraction_Homo sapiens_hsa042600.33302070
81Metabolic pathways_Homo sapiens_hsa011000.33149189
82Galactose metabolism_Homo sapiens_hsa000520.32711402
83MicroRNAs in cancer_Homo sapiens_hsa052060.31096236
84beta-Alanine metabolism_Homo sapiens_hsa004100.30477264
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30263127
86Small cell lung cancer_Homo sapiens_hsa052220.29926304
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26725685
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26676156
89TGF-beta signaling pathway_Homo sapiens_hsa043500.26561458
90Alzheimers disease_Homo sapiens_hsa050100.25531792
91Apoptosis_Homo sapiens_hsa042100.24758767
92Hippo signaling pathway_Homo sapiens_hsa043900.24709045
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24591413
94Colorectal cancer_Homo sapiens_hsa052100.24279319
95Shigellosis_Homo sapiens_hsa051310.21005532
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19147169
97HIF-1 signaling pathway_Homo sapiens_hsa040660.18793982
98Notch signaling pathway_Homo sapiens_hsa043300.18113499
99Primary immunodeficiency_Homo sapiens_hsa053400.17334641
100Bladder cancer_Homo sapiens_hsa052190.17271207
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17249456
102Tyrosine metabolism_Homo sapiens_hsa003500.17213425
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16389277
104Hedgehog signaling pathway_Homo sapiens_hsa043400.16113857
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16015656
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.15920374
107Hepatitis B_Homo sapiens_hsa051610.15080073
108Pyruvate metabolism_Homo sapiens_hsa006200.14011333
109Renin-angiotensin system_Homo sapiens_hsa046140.13963275
110Tryptophan metabolism_Homo sapiens_hsa003800.13942520
111Fat digestion and absorption_Homo sapiens_hsa049750.13036088
112Arginine and proline metabolism_Homo sapiens_hsa003300.12804191
113Pathways in cancer_Homo sapiens_hsa052000.11058569
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09785102
115Measles_Homo sapiens_hsa051620.08749711
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.08736788
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08115380
118Arginine biosynthesis_Homo sapiens_hsa002200.07547742
119Regulation of autophagy_Homo sapiens_hsa041400.07036075
120Arachidonic acid metabolism_Homo sapiens_hsa005900.03790787
121Influenza A_Homo sapiens_hsa051640.02623977
122Viral myocarditis_Homo sapiens_hsa054160.01837763
123Chronic myeloid leukemia_Homo sapiens_hsa052200.00333405
124Acute myeloid leukemia_Homo sapiens_hsa05221-0.0244918
125Wnt signaling pathway_Homo sapiens_hsa04310-0.0149775

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »