APEX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.53055515
2DNA replication checkpoint (GO:0000076)4.49475360
3kinetochore organization (GO:0051383)4.18329009
4protein localization to kinetochore (GO:0034501)4.12192863
5kinetochore assembly (GO:0051382)4.11167341
6mitotic metaphase plate congression (GO:0007080)4.00596357
7DNA replication initiation (GO:0006270)3.97474659
8establishment of integrated proviral latency (GO:0075713)3.89343918
9CENP-A containing nucleosome assembly (GO:0034080)3.89273284
10spliceosomal snRNP assembly (GO:0000387)3.86650493
11maturation of SSU-rRNA (GO:0030490)3.82853426
12telomere maintenance via semi-conservative replication (GO:0032201)3.79611051
13chromatin remodeling at centromere (GO:0031055)3.78604153
14DNA strand elongation involved in DNA replication (GO:0006271)3.78203981
15ribosome assembly (GO:0042255)3.78129286
16regulation of nuclear cell cycle DNA replication (GO:0033262)3.77344339
17protein maturation by protein folding (GO:0022417)3.76325260
18DNA strand elongation (GO:0022616)3.75561337
19spliceosomal complex assembly (GO:0000245)3.71069009
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69105790
21ribosomal large subunit biogenesis (GO:0042273)3.63866664
22telomere maintenance via recombination (GO:0000722)3.60550668
23establishment of viral latency (GO:0019043)3.57155939
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51415263
25negative regulation of ligase activity (GO:0051352)3.50282572
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.50282572
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48099113
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46995444
29regulation of mitochondrial translation (GO:0070129)3.46443966
30metaphase plate congression (GO:0051310)3.46401435
31DNA replication-independent nucleosome organization (GO:0034724)3.44147735
32DNA replication-independent nucleosome assembly (GO:0006336)3.44147735
33ribosomal small subunit assembly (GO:0000028)3.44016339
34mitotic recombination (GO:0006312)3.42967413
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41204812
36protein localization to chromosome, centromeric region (GO:0071459)3.35357586
37intra-S DNA damage checkpoint (GO:0031573)3.31732895
38mitotic chromosome condensation (GO:0007076)3.31550353
39telomere maintenance via telomere lengthening (GO:0010833)3.29315004
40DNA strand renaturation (GO:0000733)3.28491121
41nuclear pore organization (GO:0006999)3.28017155
42mismatch repair (GO:0006298)3.26359670
43folic acid-containing compound biosynthetic process (GO:0009396)3.24299269
44mitotic nuclear envelope disassembly (GO:0007077)3.22769804
45regulation of translational termination (GO:0006449)3.22146213
46DNA unwinding involved in DNA replication (GO:0006268)3.21603966
47translational termination (GO:0006415)3.20970573
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.20886875
49viral transcription (GO:0019083)3.20453066
50pseudouridine synthesis (GO:0001522)3.19175664
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.18754934
52ribonucleoprotein complex biogenesis (GO:0022613)3.17217144
53nucleobase biosynthetic process (GO:0046112)3.16506438
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14655020
55viral mRNA export from host cell nucleus (GO:0046784)3.14474702
56purine nucleobase biosynthetic process (GO:0009113)3.14364941
57spindle checkpoint (GO:0031577)3.14063720
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12064640
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10108349
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10108349
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09643818
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09643818
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09643818
64regulation of cellular amino acid metabolic process (GO:0006521)3.08654546
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08390632
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08078917
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.08078917
68nucleobase-containing small molecule interconversion (GO:0015949)3.07483994
69histone exchange (GO:0043486)3.04358546
70positive regulation of DNA-dependent DNA replication (GO:2000105)3.03885323
71meiotic chromosome segregation (GO:0045132)3.02555945
72ribosomal small subunit biogenesis (GO:0042274)3.01743086
73mitotic spindle checkpoint (GO:0071174)3.01623938
74rRNA modification (GO:0000154)3.00455539
75signal transduction involved in cell cycle checkpoint (GO:0072395)2.99093846
76establishment of chromosome localization (GO:0051303)2.98755002
77ribosome biogenesis (GO:0042254)2.98452059
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98186854
79spindle assembly checkpoint (GO:0071173)2.97634670
80IMP biosynthetic process (GO:0006188)2.97256251
81negative regulation of chromosome segregation (GO:0051985)2.97155455
82formation of translation preinitiation complex (GO:0001731)2.96268573
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94604674
84negative regulation of sister chromatid segregation (GO:0033046)2.94604674
85negative regulation of mitotic sister chromatid separation (GO:2000816)2.94604674
86negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94604674
87telomere organization (GO:0032200)2.92896612
88telomere maintenance (GO:0000723)2.92689572
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.92627266
90termination of RNA polymerase III transcription (GO:0006386)2.92627266
91pteridine-containing compound biosynthetic process (GO:0042559)2.91979599
92pentose-phosphate shunt (GO:0006098)2.91620230
93mitotic spindle assembly checkpoint (GO:0007094)2.91329303
94mitotic sister chromatid segregation (GO:0000070)2.90672685
95regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89920474
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89611553
97protein K6-linked ubiquitination (GO:0085020)2.88382662
98positive regulation of ligase activity (GO:0051351)2.88159500
99protein targeting to mitochondrion (GO:0006626)2.86342509
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86168613
101nuclear pore complex assembly (GO:0051292)2.86133787
102NADPH regeneration (GO:0006740)2.85652890
103membrane disassembly (GO:0030397)2.83882055
104nuclear envelope disassembly (GO:0051081)2.83882055
105mitotic nuclear envelope reassembly (GO:0007084)2.83877842
106nuclear envelope reassembly (GO:0031468)2.83877842
107regulation of ubiquitin-protein transferase activity (GO:0051438)2.83530683
108translational initiation (GO:0006413)2.82180668
109proline biosynthetic process (GO:0006561)2.82003364
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79629132
111oxidative phosphorylation (GO:0006119)2.79266824
112* DNA catabolic process, exonucleolytic (GO:0000738)2.78875513
113cell cycle G1/S phase transition (GO:0044843)2.78638874
114G1/S transition of mitotic cell cycle (GO:0000082)2.78638874
115IMP metabolic process (GO:0046040)2.78059541
116maturation of 5.8S rRNA (GO:0000460)2.77810883
117transcription-coupled nucleotide-excision repair (GO:0006283)2.77224774
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.76788564
119DNA replication-dependent nucleosome assembly (GO:0006335)2.76693018
120DNA replication-dependent nucleosome organization (GO:0034723)2.76693018
121tRNA methylation (GO:0030488)2.76347096
122regulation of ligase activity (GO:0051340)2.75687614
123transcription from mitochondrial promoter (GO:0006390)2.75436493
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75382948
125translational elongation (GO:0006414)2.75346770
126DNA deamination (GO:0045006)2.74450024
127rRNA processing (GO:0006364)2.73769944
128negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73499001
129Golgi transport vesicle coating (GO:0048200)2.72717716
130COPI coating of Golgi vesicle (GO:0048205)2.72717716
131regulation of sister chromatid segregation (GO:0033045)2.71724241
132regulation of mitotic sister chromatid separation (GO:0010965)2.71724241
133regulation of mitotic sister chromatid segregation (GO:0033047)2.71724241
134replication fork processing (GO:0031297)2.70606958
135nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.69668508
136pore complex assembly (GO:0046931)2.68978542
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68488339
138sister chromatid segregation (GO:0000819)2.68427206
139GDP-mannose metabolic process (GO:0019673)2.67924345
140ATP-dependent chromatin remodeling (GO:0043044)2.67208039
141negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66443230
142negative regulation of DNA-templated transcription, elongation (GO:0032785)2.66443230
143cellular component biogenesis (GO:0044085)2.65707333
144rRNA metabolic process (GO:0016072)2.65105945
145tRNA aminoacylation for protein translation (GO:0006418)2.64963825
146mitochondrial RNA metabolic process (GO:0000959)2.64379599
147* base-excision repair (GO:0006284)2.62676821
148RNA splicing, via transesterification reactions (GO:0000375)2.62508902
149regulation of DNA damage checkpoint (GO:2000001)2.62420791
150regulation of DNA-dependent DNA replication (GO:0090329)2.62283728
151histone mRNA metabolic process (GO:0008334)2.61798303
152antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.61152641
153tRNA aminoacylation (GO:0043039)2.60829461
154amino acid activation (GO:0043038)2.60829461
155pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.60824000
156somatic hypermutation of immunoglobulin genes (GO:0016446)2.60786979
157somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60786979
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.60104485
159guanosine-containing compound biosynthetic process (GO:1901070)2.59813428
160regulation of translational fidelity (GO:0006450)2.58242705
161pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.58107735
162folic acid metabolic process (GO:0046655)2.57864152
163rRNA methylation (GO:0031167)2.57849882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.82042901
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.29348478
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16836807
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.98452834
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64217517
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57127289
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.05497957
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86491873
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.82295049
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80406615
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78644024
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75278443
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68732577
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66808052
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.64635112
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.58368514
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55337566
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44864466
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40847493
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31529624
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30189134
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26464468
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24286270
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22176621
25FOXP3_21729870_ChIP-Seq_TREG_Human2.22124900
26XRN2_22483619_ChIP-Seq_HELA_Human2.20881820
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20312070
28* E2F1_21310950_ChIP-Seq_MCF-7_Human2.17909914
29VDR_23849224_ChIP-Seq_CD4+_Human2.17439474
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13258766
31DCP1A_22483619_ChIP-Seq_HELA_Human2.11106956
32TTF2_22483619_ChIP-Seq_HELA_Human2.02242588
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00860096
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96202419
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93360664
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.91270087
37ELK1_19687146_ChIP-ChIP_HELA_Human1.90166087
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86271199
39CIITA_25753668_ChIP-Seq_RAJI_Human1.83353422
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82126488
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77430967
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77110488
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.77037776
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76790870
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76735370
46GABP_19822575_ChIP-Seq_HepG2_Human1.74841617
47AR_21909140_ChIP-Seq_LNCAP_Human1.74479611
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70702339
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68451828
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68230293
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66718790
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.65006612
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55431365
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54041701
55MYC_18940864_ChIP-ChIP_HL60_Human1.53202185
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51555909
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48689428
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47613391
59ZNF263_19887448_ChIP-Seq_K562_Human1.44612166
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.42981514
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39745167
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38392732
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34327235
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33875724
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31975394
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29521869
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29234563
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28158714
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25684271
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24377644
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23633267
72VDR_21846776_ChIP-Seq_THP-1_Human1.21908233
73KDM5A_27292631_Chip-Seq_BREAST_Human1.21440113
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21313615
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20462135
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19242242
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17753595
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17222012
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16073139
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13803289
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10855777
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10625279
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08619286
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07166980
85TFEB_21752829_ChIP-Seq_HELA_Human1.06993703
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06585714
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06538653
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05805108
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.03651222
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03394357
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99651721
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97701818
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97106269
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.96037782
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95978841
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95843688
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95836255
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93767107
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.93727093
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91658586
101MYC_22102868_ChIP-Seq_BL_Human0.91581911
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89312292
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89076112
104ATF3_27146783_Chip-Seq_COLON_Human0.88246020
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87886763
106SALL1_21062744_ChIP-ChIP_HESCs_Human0.87232541
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86170827
108TET1_21451524_ChIP-Seq_MESCs_Mouse0.83832342
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83194604
110RACK7_27058665_Chip-Seq_MCF-7_Human0.83104802
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82944388
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81995379
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81192719
114* SPI1_23547873_ChIP-Seq_NB4_Human0.77396412
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.77391240
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77363149
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76741632
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75399191
119* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74607124
120* NANOG_16153702_ChIP-ChIP_HESCs_Human0.72968868
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.71888300
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68332320
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.68118789
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67673360
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.66783420
126IRF1_19129219_ChIP-ChIP_H3396_Human0.65551393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.64718013
2MP0003111_abnormal_nucleus_morphology3.72219734
3MP0010094_abnormal_chromosome_stability3.71805284
4MP0008057_abnormal_DNA_replication3.51702196
5MP0006292_abnormal_olfactory_placode3.46958183
6MP0008058_abnormal_DNA_repair3.44428095
7MP0003806_abnormal_nucleotide_metabolis3.36173537
8MP0003077_abnormal_cell_cycle3.18456469
9MP0004957_abnormal_blastocyst_morpholog2.73442661
10MP0008007_abnormal_cellular_replicative2.49190393
11MP0008932_abnormal_embryonic_tissue2.26573890
12MP0009697_abnormal_copulation2.11625564
13MP0002102_abnormal_ear_morphology2.07533226
14MP0003186_abnormal_redox_activity1.93119227
15MP0006036_abnormal_mitochondrial_physio1.92678515
16MP0000566_synostosis1.92277797
17MP0005058_abnormal_lysosome_morphology1.88688749
18MP0002877_abnormal_melanocyte_morpholog1.78117352
19MP0010030_abnormal_orbit_morphology1.73588208
20MP0001188_hyperpigmentation1.71746076
21MP0003890_abnormal_embryonic-extraembry1.70533165
22MP0001853_heart_inflammation1.70379975
23MP0006035_abnormal_mitochondrial_morpho1.70366009
24MP0002396_abnormal_hematopoietic_system1.69624711
25MP0000490_abnormal_crypts_of1.69590916
26MP0003786_premature_aging1.66549658
27MP0000350_abnormal_cell_proliferation1.66548883
28MP0003121_genomic_imprinting1.65042985
29MP0005451_abnormal_body_composition1.64438772
30MP0005501_abnormal_skin_physiology1.63306658
31MP0001293_anophthalmia1.57793253
32MP0002796_impaired_skin_barrier1.53703632
33MP0003718_maternal_effect1.50946998
34MP0000358_abnormal_cell_content/1.50704306
35MP0002938_white_spotting1.49163780
36MP0002132_abnormal_respiratory_system1.45850805
37MP0009053_abnormal_anal_canal1.42877537
38MP0003123_paternal_imprinting1.41134053
39MP0005380_embryogenesis_phenotype1.39859218
40MP0001672_abnormal_embryogenesis/_devel1.39859218
41MP0000049_abnormal_middle_ear1.37161497
42MP0004147_increased_porphyrin_level1.35740816
43MP0010234_abnormal_vibrissa_follicle1.32157000
44MP0001730_embryonic_growth_arrest1.30492311
45MP0003122_maternal_imprinting1.30472883
46MP0003566_abnormal_cell_adhesion1.27391115
47MP0009840_abnormal_foam_cell1.26359703
48MP0004808_abnormal_hematopoietic_stem1.26349564
49MP0003941_abnormal_skin_development1.24791164
50MP0002085_abnormal_embryonic_tissue1.23820427
51MP0003937_abnormal_limbs/digits/tail_de1.23353625
52MP0001697_abnormal_embryo_size1.20475023
53MP0002088_abnormal_embryonic_growth/wei1.18076495
54MP0003984_embryonic_growth_retardation1.17357037
55MP0005257_abnormal_intraocular_pressure1.16169433
56MP0003315_abnormal_perineum_morphology1.13808903
57MP0008789_abnormal_olfactory_epithelium1.13787285
58MP0005083_abnormal_biliary_tract1.13776710
59MP0002277_abnormal_respiratory_mucosa1.12932395
60MP0003656_abnormal_erythrocyte_physiolo1.12825659
61* MP0000313_abnormal_cell_death1.11630710
62MP0008877_abnormal_DNA_methylation1.11240553
63MP0010307_abnormal_tumor_latency1.10456015
64MP0004233_abnormal_muscle_weight1.08365516
65MP0003191_abnormal_cellular_cholesterol1.07090699
66MP0004185_abnormal_adipocyte_glucose1.06703793
67MP0001216_abnormal_epidermal_layer1.06448103
68MP0005076_abnormal_cell_differentiation1.06322612
69MP0003567_abnormal_fetal_cardiomyocyte1.05680698
70MP0002080_prenatal_lethality1.04891876
71MP0004197_abnormal_fetal_growth/weight/1.04406862
72MP0003453_abnormal_keratinocyte_physiol1.04359270
73MP0001286_abnormal_eye_development1.03970951
74MP0001119_abnormal_female_reproductive1.03820885
75MP0002084_abnormal_developmental_patter1.03378992
76MP0001873_stomach_inflammation1.03080417
77MP0000858_altered_metastatic_potential1.02653910
78MP0002019_abnormal_tumor_incidence1.01042078
79MP0001881_abnormal_mammary_gland1.00529714
80MP0002160_abnormal_reproductive_system1.00163112
81* MP0009672_abnormal_birth_weight0.99987462
82MP0002751_abnormal_autonomic_nervous0.99413847
83MP0010352_gastrointestinal_tract_polyps0.99356569
84MP0002111_abnormal_tail_morphology0.98356066
85MP0003385_abnormal_body_wall0.98177365
86MP0002163_abnormal_gland_morphology0.97628566
87MP0003755_abnormal_palate_morphology0.96950266
88* MP0009333_abnormal_splenocyte_physiolog0.96866420
89MP0001661_extended_life_span0.95547508
90MP0002148_abnormal_hypersensitivity_rea0.94042717
91* MP0009703_decreased_birth_body0.93898072
92MP0000428_abnormal_craniofacial_morphol0.93601402
93MP0003119_abnormal_digestive_system0.93346070
94MP0002722_abnormal_immune_system0.92954748
95MP0001849_ear_inflammation0.92555154
96MP0000678_abnormal_parathyroid_gland0.92240813
97MP0000015_abnormal_ear_pigmentation0.91730177
98MP0002254_reproductive_system_inflammat0.91538031
99MP0003763_abnormal_thymus_physiology0.91515421
100MP0005384_cellular_phenotype0.91123836
101MP0002210_abnormal_sex_determination0.90506911
102MP0002932_abnormal_joint_morphology0.90035857
103MP0002127_abnormal_cardiovascular_syste0.89691212
104MP0001727_abnormal_embryo_implantation0.89549237
105MP0002177_abnormal_outer_ear0.89213290
106* MP0000703_abnormal_thymus_morphology0.88905158
107MP0009379_abnormal_foot_pigmentation0.88775331
108MP0002638_abnormal_pupillary_reflex0.88753850
109MP0002249_abnormal_larynx_morphology0.87389378
110MP0003136_yellow_coat_color0.86899996
111* MP0002429_abnormal_blood_cell0.86034057
112MP0005503_abnormal_tendon_morphology0.85958577
113MP0000689_abnormal_spleen_morphology0.85469808
114MP0003935_abnormal_craniofacial_develop0.85424265
115MP0002086_abnormal_extraembryonic_tissu0.85327274
116MP0005389_reproductive_system_phenotype0.84719830
117MP0005621_abnormal_cell_physiology0.84509600
118MP0000685_abnormal_immune_system0.83048286
119MP0004133_heterotaxia0.83028163
120MP0009250_abnormal_appendicular_skeleto0.82676976
121MP0003938_abnormal_ear_development0.81493713
122MP0002139_abnormal_hepatobiliary_system0.81140181
123MP0000432_abnormal_head_morphology0.79802026
124MP0003942_abnormal_urinary_system0.79483646
125MP0005174_abnormal_tail_pigmentation0.77357219
126* MP0002398_abnormal_bone_marrow0.77278881
127MP0001764_abnormal_homeostasis0.77030074
128MP0002697_abnormal_eye_size0.76686026
129MP0002060_abnormal_skin_morphology0.76674787
130MP0002116_abnormal_craniofacial_bone0.76297374
131MP0009931_abnormal_skin_appearance0.75950340
132MP0001835_abnormal_antigen_presentation0.75552136
133MP0004264_abnormal_extraembryonic_tissu0.75512868
134MP0005464_abnormal_platelet_physiology0.73896293
135MP0004947_skin_inflammation0.73199097
136MP0002109_abnormal_limb_morphology0.72789687
137MP0001145_abnormal_male_reproductive0.72664255
138MP0000609_abnormal_liver_physiology0.72424947
139MP0000613_abnormal_salivary_gland0.72256355
140MP0005394_taste/olfaction_phenotype0.71561466
141MP0005499_abnormal_olfactory_system0.71561466
142MP0002282_abnormal_trachea_morphology0.71176621
143MP0002006_tumorigenesis0.70602673
144MP0003950_abnormal_plasma_membrane0.70134863
145MP0008260_abnormal_autophagy0.70131709
146MP0005408_hypopigmentation0.70073129
147MP0009278_abnormal_bone_marrow0.67840939
148MP0009785_altered_susceptibility_to0.67584389
149MP0000627_abnormal_mammary_gland0.67516300
150MP0008469_abnormal_protein_level0.67359338
151MP0005397_hematopoietic_system_phenotyp0.67156929
152MP0001545_abnormal_hematopoietic_system0.67156929
153MP0005319_abnormal_enzyme/_coenzyme0.67103894
154MP0001879_abnormal_lymphatic_vessel0.67021683
155MP0005330_cardiomyopathy0.66839646
156MP0002233_abnormal_nose_morphology0.66167155
157MP0000598_abnormal_liver_morphology0.65493227

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.94053206
2Chromsome breakage (HP:0040012)4.86793888
3Reticulocytopenia (HP:0001896)4.24054661
4Birth length less than 3rd percentile (HP:0003561)3.87891067
5Meckel diverticulum (HP:0002245)3.58790668
6Abnormality of the ileum (HP:0001549)3.43879840
7Abnormal number of incisors (HP:0011064)3.34828481
8Abnormal gallbladder physiology (HP:0012438)3.33671132
9Cholecystitis (HP:0001082)3.33671132
10Abnormality of glycolysis (HP:0004366)3.26602018
11Impulsivity (HP:0100710)3.26439475
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.25725889
13Patellar aplasia (HP:0006443)3.21308991
14Hepatocellular necrosis (HP:0001404)3.20807275
15Abnormality of chromosome stability (HP:0003220)3.19394609
16Abnormal mitochondria in muscle tissue (HP:0008316)3.17342001
17Aplasia/Hypoplasia of the patella (HP:0006498)3.15681707
18Ragged-red muscle fibers (HP:0003200)3.13402158
19Ectopic kidney (HP:0000086)3.13394160
20Increased serum pyruvate (HP:0003542)3.12981593
21Progressive muscle weakness (HP:0003323)3.12149472
22Abnormality of the preputium (HP:0100587)3.03999737
23Hepatic necrosis (HP:0002605)3.00576621
24Acute necrotizing encephalopathy (HP:0006965)2.99537055
25Increased CSF lactate (HP:0002490)2.97614447
26Acute encephalopathy (HP:0006846)2.89623232
27Mitochondrial inheritance (HP:0001427)2.86611281
28Testicular atrophy (HP:0000029)2.84822824
29Increased serum lactate (HP:0002151)2.83514742
30Abnormal protein glycosylation (HP:0012346)2.77754454
31Abnormal glycosylation (HP:0012345)2.77754454
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77754454
33Abnormal protein N-linked glycosylation (HP:0012347)2.77754454
34Sparse eyelashes (HP:0000653)2.77330203
35Multiple enchondromatosis (HP:0005701)2.76344318
36Reduced antithrombin III activity (HP:0001976)2.71172180
37Breast hypoplasia (HP:0003187)2.70812665
38Triphalangeal thumb (HP:0001199)2.68849243
39Trismus (HP:0000211)2.66931015
40Abnormal trabecular bone morphology (HP:0100671)2.65825681
41Absent radius (HP:0003974)2.61591852
42Petechiae (HP:0000967)2.56082523
43Facial cleft (HP:0002006)2.55498846
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54713501
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54713501
46Duplicated collecting system (HP:0000081)2.53362434
47Pallor (HP:0000980)2.49900090
48Abnormality of DNA repair (HP:0003254)2.49880154
49Small intestinal stenosis (HP:0012848)2.46609582
50Duodenal stenosis (HP:0100867)2.46609582
51Concave nail (HP:0001598)2.45433163
52Abnormality of the umbilical cord (HP:0010881)2.44680776
53Abnormality of pyrimidine metabolism (HP:0004353)2.44280574
54Abnormality of the renal collecting system (HP:0004742)2.43141702
55Lactic acidosis (HP:0003128)2.41751739
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41225730
57Absent thumb (HP:0009777)2.39707175
58Squamous cell carcinoma (HP:0002860)2.39340024
59Cerebral edema (HP:0002181)2.36927389
60Horseshoe kidney (HP:0000085)2.35813557
61Aplasia involving forearm bones (HP:0009822)2.34704307
62Absent forearm bone (HP:0003953)2.34704307
63Microvesicular hepatic steatosis (HP:0001414)2.32471140
64Abnormal umbilical cord blood vessels (HP:0011403)2.31774836
65Single umbilical artery (HP:0001195)2.31774836
66Abnormality of the fetal cardiovascular system (HP:0010948)2.31774836
67Myelodysplasia (HP:0002863)2.30813251
68Hypokinesia (HP:0002375)2.27790538
69Abnormality of the carotid arteries (HP:0005344)2.26313304
70Optic nerve coloboma (HP:0000588)2.25511068
71Exercise intolerance (HP:0003546)2.25167906
72Bone marrow hypocellularity (HP:0005528)2.25101281
73Macrocytic anemia (HP:0001972)2.23725210
74Abnormality of abdominal situs (HP:0011620)2.23561924
75Abdominal situs inversus (HP:0003363)2.23561924
76Microretrognathia (HP:0000308)2.23053547
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22175867
78Pancytopenia (HP:0001876)2.21874516
79Secondary amenorrhea (HP:0000869)2.16638870
80Premature graying of hair (HP:0002216)2.15934576
81Progressive macrocephaly (HP:0004481)2.14936424
82Increased hepatocellular lipid droplets (HP:0006565)2.13959443
83Clubbing of toes (HP:0100760)2.13767528
84Hepatosplenomegaly (HP:0001433)2.13707913
85Nephroblastoma (Wilms tumor) (HP:0002667)2.12283247
86Entropion (HP:0000621)2.11992795
87Tracheoesophageal fistula (HP:0002575)2.11785216
88Abnormality of the labia minora (HP:0012880)2.09908339
89Rough bone trabeculation (HP:0100670)2.07537765
90Selective tooth agenesis (HP:0001592)2.06863125
91Short middle phalanx of the 5th finger (HP:0004220)2.06733744
92Abnormality of the duodenum (HP:0002246)2.06471912
93Agnosia (HP:0010524)2.05927997
94Short thumb (HP:0009778)2.05733331
95Renal Fanconi syndrome (HP:0001994)2.05722192
96Rhabdomyosarcoma (HP:0002859)2.05596891
97Sloping forehead (HP:0000340)2.05424471
98Abnormalities of placenta or umbilical cord (HP:0001194)2.04920065
99Hypertensive crisis (HP:0100735)2.04735861
100Pancreatic fibrosis (HP:0100732)2.03024961
101Respiratory failure (HP:0002878)2.02894824
102Abnormality of the incisor (HP:0000676)2.00543367
103Abnormal number of erythroid precursors (HP:0012131)2.00435430
104Oral leukoplakia (HP:0002745)1.99980051
105Increased intramyocellular lipid droplets (HP:0012240)1.99847816
106Ileus (HP:0002595)1.99000828
107Abnormality of reticulocytes (HP:0004312)1.98928484
108Aplastic anemia (HP:0001915)1.98771996
109Atresia of the external auditory canal (HP:0000413)1.98399230
110Embryonal renal neoplasm (HP:0011794)1.97356297
111Duplication of thumb phalanx (HP:0009942)1.97299894
112Preaxial hand polydactyly (HP:0001177)1.95494152
113Medulloblastoma (HP:0002885)1.94635194
114Abnormality of cells of the erythroid lineage (HP:0012130)1.94243913
115Supernumerary spleens (HP:0009799)1.93796103
116Median cleft lip (HP:0000161)1.92310732
117Progressive external ophthalmoplegia (HP:0000590)1.91619280
118Poikiloderma (HP:0001029)1.91547675
119Lipid accumulation in hepatocytes (HP:0006561)1.91154587
120Abnormal lung lobation (HP:0002101)1.89563595
121Cleft eyelid (HP:0000625)1.89055445
122Abnormality of the phalanges of the hallux (HP:0010057)1.87428754
123Respiratory difficulties (HP:0002880)1.85827397
124Abnormality of the fingertips (HP:0001211)1.85144427
125Cellular immunodeficiency (HP:0005374)1.84113280
126Cholelithiasis (HP:0001081)1.83820382
127Prostate neoplasm (HP:0100787)1.83427846
128Flat capital femoral epiphysis (HP:0003370)1.83046245
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82585304
130Congenital, generalized hypertrichosis (HP:0004540)1.81030232
131Reduced subcutaneous adipose tissue (HP:0003758)1.80345472
132Abnormality of the anterior horn cell (HP:0006802)1.79911469
133Degeneration of anterior horn cells (HP:0002398)1.79911469
134Hypergonadotropic hypogonadism (HP:0000815)1.78697488
135Increased muscle lipid content (HP:0009058)1.77710230
136Congenital ichthyosiform erythroderma (HP:0007431)1.76537429
137Intestinal fistula (HP:0100819)1.75892029
138Abnormality of the distal phalanges of the toes (HP:0010182)1.75745391
139Neoplasm of the pancreas (HP:0002894)1.74675404
140Proximal placement of thumb (HP:0009623)1.73861920
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.73044245
142Neoplasm of striated muscle (HP:0009728)1.72828285
143Short 4th metacarpal (HP:0010044)1.72643372
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72643372
145Upper limb muscle weakness (HP:0003484)1.72597178
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72131157
147Carpal bone hypoplasia (HP:0001498)1.69630703
148Ependymoma (HP:0002888)1.69282777
149Septate vagina (HP:0001153)1.69005239
150Shawl scrotum (HP:0000049)1.68990774
151Mesomelia (HP:0003027)1.68102264
152Nausea (HP:0002018)1.67968045
153Reticulocytosis (HP:0001923)1.67496154
154Abnormal gallbladder morphology (HP:0012437)1.67088275
155Abnormality of the metopic suture (HP:0005556)1.66929356
156Adrenal hypoplasia (HP:0000835)1.65595936
157Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65475697
158Increased serum ferritin (HP:0003281)1.65042347
159Rectal fistula (HP:0100590)1.65018475
160Rectovaginal fistula (HP:0000143)1.65018475
161Paralysis (HP:0003470)1.64165491
162Fasciculations (HP:0002380)1.63899651
163Midline defect of the nose (HP:0004122)1.63132923
164Submucous cleft hard palate (HP:0000176)1.62074991
165Bifid tongue (HP:0010297)1.61064148
166Prominent nose (HP:0000448)1.60540608
167Congenital hepatic fibrosis (HP:0002612)1.59538556
168Pancreatic cysts (HP:0001737)1.59524211
169Type I transferrin isoform profile (HP:0003642)1.59429112
170Increased number of teeth (HP:0011069)1.57402789
171Abnormality of the intervertebral disk (HP:0005108)1.56073513
172Premature ovarian failure (HP:0008209)1.54434578
173Long eyelashes (HP:0000527)1.53518990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.71273721
2VRK24.12892730
3SRPK13.73164998
4BUB12.86520587
5CDC72.67258981
6INSRR2.56001184
7STK162.54008149
8WEE12.45680606
9SMG12.42531593
10MKNK22.29090693
11MKNK12.29083242
12EIF2AK12.26855940
13PLK42.22894002
14NEK12.07521797
15ZAK1.99154854
16AKT31.97609649
17MST41.94907046
18TTK1.93964497
19VRK11.93495629
20BRSK21.86802949
21ATR1.82061095
22EIF2AK21.81120293
23CDK71.81034531
24PLK11.78620246
25DYRK31.78428493
26ACVR1B1.74311169
27ERN11.70177197
28STK38L1.69672903
29PAK41.69423364
30TESK11.66283642
31LATS11.64881953
32BRD41.62630392
33CDK121.60029008
34PDK21.59717704
35AURKB1.52719806
36RPS6KA41.50989024
37NME21.41104382
38MST1R1.39657230
39NEK21.38913212
40BCKDK1.36526237
41CHEK21.33726593
42TXK1.30560118
43PLK31.26484676
44YES11.25739041
45CDK81.23272295
46ARAF1.19018144
47SIK31.16484170
48STK41.16411996
49EIF2AK31.10182699
50SCYL21.09928127
51TAF11.06423352
52BRAF1.02107326
53PASK1.02081736
54TEC1.01052407
55TRIB31.00949954
56TSSK61.00514675
57PIM10.99504486
58STK30.95923785
59AURKA0.95385042
60ATM0.94568005
61DAPK10.93506466
62PBK0.92529923
63MAP3K120.92195194
64IRAK40.91340942
65CHEK10.89538478
66BRSK10.88219155
67TAOK20.87762409
68CDK40.85012663
69CASK0.82661005
70IRAK30.82474286
71LIMK10.81831860
72MAP3K80.81462446
73NLK0.80465391
74RPS6KA50.80009264
75IKBKB0.78353238
76LRRK20.78030383
77ILK0.75037751
78LMTK20.74838840
79STK100.74718159
80MAP3K110.73973485
81TGFBR10.72891375
82GRK10.72852201
83TBK10.69276461
84CDK20.69176282
85PRPF4B0.68898006
86PRKCI0.66785708
87CLK10.65045047
88DYRK20.64592954
89CSNK2A10.64383566
90NEK90.63410709
91ABL20.63172404
92JAK30.62972344
93SIK10.62563620
94CHUK0.61063372
95TESK20.60816297
96CDK10.58964242
97MAP3K140.57948898
98MAP3K30.56710180
99CSNK2A20.56130122
100TRIM280.54945522
101EEF2K0.53290631
102MAPKAPK30.51996546
103MAPK110.51684659
104ERBB40.51208792
105EPHA20.50897316
106IRAK20.50490798
107MAP2K30.49320970
108MELK0.48218716
109BLK0.47420886
110ALK0.46995659
111CAMK1D0.45428430
112MAPKAPK20.45405811
113LATS20.45189886
114MAP2K60.43643102
115IRAK10.42882778
116NUAK10.42184670
117MAP4K10.42051715
118ICK0.41948839
119RPS6KB20.41053923
120BMX0.40942277
121STK240.40881303
122CAMK40.40825864
123ERBB20.40631140
124MET0.39691843
125BTK0.38563260
126PRKAA20.38364464
127CDC42BPA0.38037204
128CDK90.37421023
129PIM20.36904820
130CSNK1G30.36441118
131LYN0.36313777
132CDK30.36148404
133WNK30.35424415
134PRKDC0.35157411
135AKT10.35123108
136DYRK1B0.34752953
137TYK20.32841776
138KIT0.31280561
139NME10.29576027
140PAK10.27575895
141MAPK140.27432218
142IKBKE0.26558599
143KDR0.26361199

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31658119
2Mismatch repair_Homo sapiens_hsa034303.92210250
3Homologous recombination_Homo sapiens_hsa034403.46404806
4RNA polymerase_Homo sapiens_hsa030203.39043228
5One carbon pool by folate_Homo sapiens_hsa006703.38375338
6Ribosome_Homo sapiens_hsa030103.22078606
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10481112
8Fanconi anemia pathway_Homo sapiens_hsa034603.08026910
9Spliceosome_Homo sapiens_hsa030402.97858822
10* Base excision repair_Homo sapiens_hsa034102.70634038
11RNA transport_Homo sapiens_hsa030132.64056697
12Cell cycle_Homo sapiens_hsa041102.59553395
13Nucleotide excision repair_Homo sapiens_hsa034202.54660541
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53774322
15Non-homologous end-joining_Homo sapiens_hsa034502.47035878
16Pyrimidine metabolism_Homo sapiens_hsa002402.42808929
17Proteasome_Homo sapiens_hsa030502.18916700
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92774692
19RNA degradation_Homo sapiens_hsa030181.88938561
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87130063
21Basal transcription factors_Homo sapiens_hsa030221.82447740
22Biosynthesis of amino acids_Homo sapiens_hsa012301.70471026
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68845088
24mRNA surveillance pathway_Homo sapiens_hsa030151.63120866
25Fatty acid elongation_Homo sapiens_hsa000621.61131071
26p53 signaling pathway_Homo sapiens_hsa041151.56763524
27Pentose phosphate pathway_Homo sapiens_hsa000301.55872954
28Carbon metabolism_Homo sapiens_hsa012001.46877061
29Oxidative phosphorylation_Homo sapiens_hsa001901.45428922
30Pyruvate metabolism_Homo sapiens_hsa006201.37857850
31Systemic lupus erythematosus_Homo sapiens_hsa053221.34562024
32Parkinsons disease_Homo sapiens_hsa050121.33439423
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29973374
34Purine metabolism_Homo sapiens_hsa002301.28173378
35Herpes simplex infection_Homo sapiens_hsa051681.23639979
36Glutathione metabolism_Homo sapiens_hsa004801.19495710
37Fructose and mannose metabolism_Homo sapiens_hsa000511.15162413
38N-Glycan biosynthesis_Homo sapiens_hsa005101.13881422
39Epstein-Barr virus infection_Homo sapiens_hsa051691.11691255
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07250838
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03865637
42Sulfur metabolism_Homo sapiens_hsa009201.00917443
43Selenocompound metabolism_Homo sapiens_hsa004501.00887417
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99940651
45Basal cell carcinoma_Homo sapiens_hsa052170.98635987
46Protein export_Homo sapiens_hsa030600.97678947
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84613345
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80644469
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.79673440
50Measles_Homo sapiens_hsa051620.79378054
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.78968311
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78523566
53Viral carcinogenesis_Homo sapiens_hsa052030.78328711
54MicroRNAs in cancer_Homo sapiens_hsa052060.78322070
55Lysine degradation_Homo sapiens_hsa003100.76461415
56Primary immunodeficiency_Homo sapiens_hsa053400.75003135
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74624595
58HTLV-I infection_Homo sapiens_hsa051660.74280552
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73604563
60Antigen processing and presentation_Homo sapiens_hsa046120.73253094
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72211318
62Folate biosynthesis_Homo sapiens_hsa007900.70304614
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69603427
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69590122
65Sulfur relay system_Homo sapiens_hsa041220.69573487
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68841349
67Hedgehog signaling pathway_Homo sapiens_hsa043400.67176337
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.66315260
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64396856
70Thyroid cancer_Homo sapiens_hsa052160.64199289
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.63096530
72Alzheimers disease_Homo sapiens_hsa050100.63079229
73Prostate cancer_Homo sapiens_hsa052150.60455056
74Allograft rejection_Homo sapiens_hsa053300.60416834
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60055624
76Steroid biosynthesis_Homo sapiens_hsa001000.59957313
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59038201
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57940281
79Propanoate metabolism_Homo sapiens_hsa006400.56520102
80Autoimmune thyroid disease_Homo sapiens_hsa053200.55993492
81Graft-versus-host disease_Homo sapiens_hsa053320.54826859
82Shigellosis_Homo sapiens_hsa051310.54743058
83Hematopoietic cell lineage_Homo sapiens_hsa046400.54533602
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.51873111
85Hepatitis B_Homo sapiens_hsa051610.51481364
86TGF-beta signaling pathway_Homo sapiens_hsa043500.50515094
87Influenza A_Homo sapiens_hsa051640.50275119
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50163757
89Arachidonic acid metabolism_Homo sapiens_hsa005900.50056115
90Apoptosis_Homo sapiens_hsa042100.49635734
91Huntingtons disease_Homo sapiens_hsa050160.49445451
92Fatty acid metabolism_Homo sapiens_hsa012120.48746904
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47528712
94Acute myeloid leukemia_Homo sapiens_hsa052210.47321882
95Small cell lung cancer_Homo sapiens_hsa052220.45953461
96Legionellosis_Homo sapiens_hsa051340.44643422
97Oocyte meiosis_Homo sapiens_hsa041140.44373247
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.43988375
99Alcoholism_Homo sapiens_hsa050340.43343148
100Hippo signaling pathway_Homo sapiens_hsa043900.43200808
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43074897
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42285862
103Melanoma_Homo sapiens_hsa052180.41009174
104Bladder cancer_Homo sapiens_hsa052190.38765835
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.38566520
106Notch signaling pathway_Homo sapiens_hsa043300.37885551
107Lysosome_Homo sapiens_hsa041420.36878111
108Asthma_Homo sapiens_hsa053100.36373789
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.36137125
110Phototransduction_Homo sapiens_hsa047440.35968892
111Vibrio cholerae infection_Homo sapiens_hsa051100.34550177
112Wnt signaling pathway_Homo sapiens_hsa043100.31234277
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28850527
114Chronic myeloid leukemia_Homo sapiens_hsa052200.28151526
115Pathways in cancer_Homo sapiens_hsa052000.28009939
116Colorectal cancer_Homo sapiens_hsa052100.27378289
117Arginine and proline metabolism_Homo sapiens_hsa003300.26644256
118Viral myocarditis_Homo sapiens_hsa054160.24993331
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24934344
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24633397
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24400054
122Leishmaniasis_Homo sapiens_hsa051400.24118955
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23999414
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23219647
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22976142
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.20730634
127FoxO signaling pathway_Homo sapiens_hsa040680.20451126
128Phenylalanine metabolism_Homo sapiens_hsa003600.20327177
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19911464
130Malaria_Homo sapiens_hsa051440.19290271
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18499229
132Adherens junction_Homo sapiens_hsa045200.17340181
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15282046
134Vitamin B6 metabolism_Homo sapiens_hsa007500.15013394
135Metabolic pathways_Homo sapiens_hsa011000.14379522
136Other glycan degradation_Homo sapiens_hsa005110.13066703
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12837172
138Galactose metabolism_Homo sapiens_hsa000520.10982871
139TNF signaling pathway_Homo sapiens_hsa046680.10864520

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