APH1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.30305084
2L-phenylalanine catabolic process (GO:0006559)5.30305084
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.24309248
4L-phenylalanine metabolic process (GO:0006558)5.24309248
5alpha-linolenic acid metabolic process (GO:0036109)4.75911473
6Golgi transport vesicle coating (GO:0048200)4.45738742
7COPI coating of Golgi vesicle (GO:0048205)4.45738742
8lysine metabolic process (GO:0006553)4.40245805
9lysine catabolic process (GO:0006554)4.40245805
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.36529562
11aromatic amino acid family catabolic process (GO:0009074)4.33961583
12glyoxylate metabolic process (GO:0046487)4.26389314
13sulfur amino acid catabolic process (GO:0000098)4.24721691
14cysteine metabolic process (GO:0006534)4.17226493
15protein localization to endosome (GO:0036010)4.09511752
16negative regulation of fibrinolysis (GO:0051918)4.03477546
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01004082
18kynurenine metabolic process (GO:0070189)3.99451028
19protein carboxylation (GO:0018214)3.89597610
20peptidyl-glutamic acid carboxylation (GO:0017187)3.89597610
21regulation of cholesterol homeostasis (GO:2000188)3.83661590
22plasma lipoprotein particle clearance (GO:0034381)3.79486452
23negative regulation of erythrocyte differentiation (GO:0045647)3.68472714
24bile acid biosynthetic process (GO:0006699)3.62141214
25regulation of triglyceride catabolic process (GO:0010896)3.61784171
26low-density lipoprotein particle clearance (GO:0034383)3.60196933
27complement activation, alternative pathway (GO:0006957)3.57832126
28pinocytosis (GO:0006907)3.57457337
29aspartate family amino acid catabolic process (GO:0009068)3.57415915
30positive regulation of Cdc42 GTPase activity (GO:0043089)3.57013795
31negative regulation of cholesterol transport (GO:0032375)3.56045297
32negative regulation of sterol transport (GO:0032372)3.56045297
33ethanol oxidation (GO:0006069)3.53811243
34urea metabolic process (GO:0019627)3.53320227
35urea cycle (GO:0000050)3.53320227
36tryptophan catabolic process (GO:0006569)3.51388502
37indole-containing compound catabolic process (GO:0042436)3.51388502
38indolalkylamine catabolic process (GO:0046218)3.51388502
39homocysteine metabolic process (GO:0050667)3.51355520
40high-density lipoprotein particle remodeling (GO:0034375)3.50255372
41regulation of fibrinolysis (GO:0051917)3.44121279
42fatty acid beta-oxidation (GO:0006635)3.43257176
43cellular modified amino acid catabolic process (GO:0042219)3.39082734
44amino-acid betaine metabolic process (GO:0006577)3.35753131
45acetyl-CoA metabolic process (GO:0006084)3.34093311
462-oxoglutarate metabolic process (GO:0006103)3.33129205
47protein retention in ER lumen (GO:0006621)3.32637568
48regulation of protein activation cascade (GO:2000257)3.32106577
49epithelial cell differentiation involved in prostate gland development (GO:0060742)3.31630408
50cellular ketone body metabolic process (GO:0046950)3.30835051
51tryptophan metabolic process (GO:0006568)3.30358934
52short-chain fatty acid metabolic process (GO:0046459)3.29317231
53positive regulation of fatty acid beta-oxidation (GO:0032000)3.28733846
54regulation of early endosome to late endosome transport (GO:2000641)3.28226773
55positive regulation of triglyceride metabolic process (GO:0090208)3.27978205
56fatty acid oxidation (GO:0019395)3.25842475
574-hydroxyproline metabolic process (GO:0019471)3.25086560
58barbed-end actin filament capping (GO:0051016)3.24596867
59regulation of fatty acid beta-oxidation (GO:0031998)3.22561922
60mannose metabolic process (GO:0006013)3.22238733
61negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21703993
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21479632
63nitrogen cycle metabolic process (GO:0071941)3.20727503
64bile acid metabolic process (GO:0008206)3.19831742
65lipid oxidation (GO:0034440)3.18393045
66pentose-phosphate shunt (GO:0006098)3.18005037
67regulation of complement activation (GO:0030449)3.17119743
68reverse cholesterol transport (GO:0043691)3.16720283
69valine metabolic process (GO:0006573)3.14121410
70serine family amino acid catabolic process (GO:0009071)3.12994723
71fatty acid catabolic process (GO:0009062)3.11564881
72maternal placenta development (GO:0001893)3.10776758
73response to mercury ion (GO:0046689)3.10684450
74alpha-amino acid catabolic process (GO:1901606)3.09176449
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08143170
76aromatic amino acid family metabolic process (GO:0009072)3.07351281
77positive regulation of triglyceride biosynthetic process (GO:0010867)3.06680314
78NADPH regeneration (GO:0006740)3.05615880
79response to laminar fluid shear stress (GO:0034616)3.05016858
80regulation of cholesterol esterification (GO:0010872)3.04707677
81triglyceride homeostasis (GO:0070328)3.04095625
82acylglycerol homeostasis (GO:0055090)3.04095625
83cholesterol homeostasis (GO:0042632)3.04012116
84phospholipid efflux (GO:0033700)3.03513230
85response to peptidoglycan (GO:0032494)3.03238886
86sterol homeostasis (GO:0055092)3.02724207
87positive regulation of lipid catabolic process (GO:0050996)3.01139815
88modulation by symbiont of host cellular process (GO:0044068)3.00594362
89plasma lipoprotein particle remodeling (GO:0034369)3.00473175
90protein-lipid complex remodeling (GO:0034368)3.00473175
91macromolecular complex remodeling (GO:0034367)3.00473175
92NIK/NF-kappaB signaling (GO:0038061)3.00389972
93protein-lipid complex assembly (GO:0065005)2.99391583
94apoptotic process involved in morphogenesis (GO:0060561)2.99107222
95regulation of cholesterol metabolic process (GO:0090181)2.98991351
96cellular amino acid catabolic process (GO:0009063)2.98256855
97glutamate metabolic process (GO:0006536)2.97361087
98regulation of mammary gland epithelial cell proliferation (GO:0033599)2.95400536
99monocarboxylic acid catabolic process (GO:0072329)2.95172900
100glycosphingolipid catabolic process (GO:0046479)2.95054137
101ethanol metabolic process (GO:0006067)2.94977864
102serine family amino acid metabolic process (GO:0009069)2.93512487
103ketone body metabolic process (GO:1902224)2.92263843
104positive regulation of lipoprotein lipase activity (GO:0051006)2.91887601
105positive regulation of triglyceride lipase activity (GO:0061365)2.91887601
106tyrosine metabolic process (GO:0006570)2.91295827
107phospholipid homeostasis (GO:0055091)2.89576346
108dicarboxylic acid biosynthetic process (GO:0043650)2.88632462
109drug catabolic process (GO:0042737)2.88605705
110regulation of cholesterol storage (GO:0010885)2.88333654
111regulation of glucose import in response to insulin stimulus (GO:2001273)2.88050475
112cholesterol efflux (GO:0033344)2.87711146
113fibrinolysis (GO:0042730)2.86248960
114plasma lipoprotein particle assembly (GO:0034377)2.86115574
115glycine metabolic process (GO:0006544)2.85521354
116serine family amino acid biosynthetic process (GO:0009070)2.85085534
117proline biosynthetic process (GO:0006561)2.83446524
118drug transmembrane transport (GO:0006855)2.83118105
119intestinal cholesterol absorption (GO:0030299)2.82638355
120lipoprotein metabolic process (GO:0042157)2.81836346
121tricarboxylic acid metabolic process (GO:0072350)2.80393644
122apoptotic cell clearance (GO:0043277)2.80066744
123positive regulation of keratinocyte differentiation (GO:0045618)2.78529044
124organic acid catabolic process (GO:0016054)2.78380526
125carboxylic acid catabolic process (GO:0046395)2.78380526
126antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78282381
127adherens junction assembly (GO:0034333)2.77254224
128activation of Rac GTPase activity (GO:0032863)2.76371795
129antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75836795
130stress fiber assembly (GO:0043149)2.75744870
131cell-substrate adherens junction assembly (GO:0007045)2.74926321
132focal adhesion assembly (GO:0048041)2.74926321
133negative regulation of cell size (GO:0045792)2.74732939
134embryonic process involved in female pregnancy (GO:0060136)2.70763995
1353-UTR-mediated mRNA stabilization (GO:0070935)2.67884507
136epithelial cell-cell adhesion (GO:0090136)2.65043609
137positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64954186
138basement membrane organization (GO:0071711)2.64252808
139modulation by virus of host process (GO:0019054)2.62574308
140regulation of extracellular matrix disassembly (GO:0010715)2.62334153
141glucose 6-phosphate metabolic process (GO:0051156)2.61890388
142glycolipid catabolic process (GO:0019377)2.61762780
143glucose catabolic process (GO:0006007)2.61708175
144endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.59085206
145positive regulation by organism of defense response of other organism involved in symbiotic interact2.56800822
146modulation by symbiont of host immune response (GO:0052553)2.56800822
147positive regulation by symbiont of host defense response (GO:0052509)2.56800822
148modulation by symbiont of host defense response (GO:0052031)2.56800822
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56800822
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56800822
151antigen processing and presentation of endogenous antigen (GO:0019883)2.53684944
152surfactant homeostasis (GO:0043129)2.48573968
153negative regulation of fatty acid transport (GO:2000192)2.48440796
154regulation of defense response to virus by virus (GO:0050690)2.46091330
155cell-substrate junction assembly (GO:0007044)2.45987925
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.45717413
157regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42708804
158response to muramyl dipeptide (GO:0032495)2.42231322
159activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42109959
160skin morphogenesis (GO:0043589)2.41888827
161detection of other organism (GO:0098543)2.40880396
162planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40351365
163positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.36965084
164detection of bacterium (GO:0016045)2.36235939
165positive regulation of nuclease activity (GO:0032075)2.33234452
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31493298
167positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31327942
168semaphorin-plexin signaling pathway (GO:0071526)2.30884114
169vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.30570697
170branching involved in mammary gland duct morphogenesis (GO:0060444)2.30245381
171positive regulation of extracellular matrix organization (GO:1903055)2.30076485
172regulation of superoxide anion generation (GO:0032928)2.29816946
173activation of MAPKKK activity (GO:0000185)2.29789175
174positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29032302
175modulation by virus of host morphology or physiology (GO:0019048)2.28240683
176cellular response to virus (GO:0098586)2.25733658
177hyaluronan catabolic process (GO:0030214)2.25552841
178desmosome organization (GO:0002934)2.23255770
179positive regulation of receptor recycling (GO:0001921)2.23177499
180regulation of leukocyte degranulation (GO:0043300)2.21829473
181negative regulation of viral release from host cell (GO:1902187)2.20524061
182positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.20178780
183RNA stabilization (GO:0043489)2.19990213
184mRNA stabilization (GO:0048255)2.19990213
185embryo implantation (GO:0007566)2.19367946
186response to thyroid hormone (GO:0097066)2.16526923
187regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.15135657
188regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.15132509
189regulation of apoptotic process involved in morphogenesis (GO:1902337)2.14804590
190endoplasmic reticulum unfolded protein response (GO:0030968)2.14418137
191regulation of extracellular matrix organization (GO:1903053)2.13967294
192antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.11646408
193regulation of lipid kinase activity (GO:0043550)2.11506764
194regulation of nuclease activity (GO:0032069)2.10831719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.88197407
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.98001850
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84001489
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.62316891
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.00145877
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.84622031
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.79824674
8CLOCK_20551151_ChIP-Seq_293T_Human2.73974270
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57379958
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.41518753
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39656905
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36023936
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35728748
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.27984099
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.22287960
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94830887
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.88764549
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87450025
19LXR_22292898_ChIP-Seq_THP-1_Human1.84956555
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81282563
21* RACK7_27058665_Chip-Seq_MCF-7_Human1.73946800
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.73775018
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.65987740
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65037495
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63806054
26ZNF263_19887448_ChIP-Seq_K562_Human1.63176475
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61435519
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.60990617
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59947994
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59074103
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56072350
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55147313
33VDR_21846776_ChIP-Seq_THP-1_Human1.49620736
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47672628
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.47655227
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46757582
37KDM2B_26808549_Chip-Seq_DND41_Human1.45097423
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37614884
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37201125
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37095381
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36994680
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36929334
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36812706
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36723705
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36371388
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.34502949
47ATF3_27146783_Chip-Seq_COLON_Human1.33955865
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32932610
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.32520980
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32436065
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.31781422
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30466104
53* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27767986
54* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26518473
55TCF7_22412390_ChIP-Seq_EML_Mouse1.26320312
56* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25085793
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.24660967
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.24660967
59* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24402312
60MYC_22102868_ChIP-Seq_BL_Human1.24345536
61* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23846474
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23701424
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22910055
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20204812
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19728685
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18879911
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18432084
68* MAF_26560356_Chip-Seq_TH2_Human1.18106610
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16716717
70GATA1_19941826_ChIP-Seq_K562_Human1.16215610
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15734722
72GATA6_25053715_ChIP-Seq_YYC3_Human1.15413292
73* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15136038
74* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14769186
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.14440329
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13826124
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.13309105
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13028136
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12811993
80GATA4_25053715_ChIP-Seq_YYC3_Human1.12430326
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.12371811
82SMC4_20622854_ChIP-Seq_HELA_Human1.10904957
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10663503
84MAF_26560356_Chip-Seq_TH1_Human1.09677375
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09245888
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08192069
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06857596
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06753551
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06513950
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05775490
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05762454
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04837385
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04767160
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04601652
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04249147
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03359661
97* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02736378
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.01992971
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01289844
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01139310
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01071012
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00486777
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00071335
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.99314400
105UBF1/2_26484160_Chip-Seq_HMECs_Human0.99170672
106* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98586428
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97532652
108FOXM1_23109430_ChIP-Seq_U2OS_Human0.97124152
109VDR_24763502_ChIP-Seq_THP-1_Human0.96889047
110* CREB1_26743006_Chip-Seq_LNCaP_Human0.96267672
111* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95766028
112NCOR1_26117541_ChIP-Seq_K562_Human0.95076339
113BCOR_27268052_Chip-Seq_Bcells_Human0.94788906
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94112688
115P68_20966046_ChIP-Seq_HELA_Human0.93243748
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92299640
117UTX_26944678_Chip-Seq_JUKART_Human0.92219489
118GATA1_22025678_ChIP-Seq_K562_Human0.91615236
119HNF4A_19822575_ChIP-Seq_HepG2_Human0.91165952
120GATA2_19941826_ChIP-Seq_K562_Human0.89088305
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89034011
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88474050
123GATA2_21666600_ChIP-Seq_HMVEC_Human0.88388634
124KDM2B_26808549_Chip-Seq_K562_Human0.87514188
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.87298270
126IRF8_27001747_Chip-Seq_BMDM_Mouse0.86873335
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86510029
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.85469430
129* RUNX1_27514584_Chip-Seq_MCF-7_Human0.85441910
130TP53_22127205_ChIP-Seq_IMR90_Human0.83574121
131* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83126890
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83105684
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83036343
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82999063
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.82536401
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82131686
137SOX2_20726797_ChIP-Seq_SW620_Human0.82033676
138ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80917538
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80239424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.27456887
2MP0002139_abnormal_hepatobiliary_system5.00486050
3MP0009840_abnormal_foam_cell3.78241080
4MP0005085_abnormal_gallbladder_physiolo3.61792018
5MP0005365_abnormal_bile_salt3.59111119
6MP0003705_abnormal_hypodermis_morpholog3.39507690
7MP0008875_abnormal_xenobiotic_pharmacok3.01487856
8MP0003806_abnormal_nucleotide_metabolis2.76077940
9MP0002877_abnormal_melanocyte_morpholog2.67225201
10MP0003191_abnormal_cellular_cholesterol2.52716948
11MP0003252_abnormal_bile_duct2.52118350
12MP0010329_abnormal_lipoprotein_level2.42678198
13MP0005083_abnormal_biliary_tract2.37832943
14MP0008438_abnormal_cutaneous_collagen2.17951217
15MP0005332_abnormal_amino_acid2.12887009
16MP0005076_abnormal_cell_differentiation2.09555455
17MP0003195_calcinosis2.08374779
18MP0001666_abnormal_nutrient_absorption2.04908892
19MP0005058_abnormal_lysosome_morphology2.01143253
20MP0008260_abnormal_autophagy2.01001817
21MP0003300_gastrointestinal_ulcer1.98437848
22MP0000858_altered_metastatic_potential1.77118689
23MP0004858_abnormal_nervous_system1.73107888
24MP0000609_abnormal_liver_physiology1.72148900
25MP0002118_abnormal_lipid_homeostasis1.65341334
26MP0003172_abnormal_lysosome_physiology1.61440929
27MP0004185_abnormal_adipocyte_glucose1.58620459
28MP0009643_abnormal_urine_homeostasis1.54235469
29MP0005257_abnormal_intraocular_pressure1.49100894
30MP0003566_abnormal_cell_adhesion1.48137529
31MP0009333_abnormal_splenocyte_physiolog1.45831638
32MP0005409_darkened_coat_color1.42468014
33MP0005319_abnormal_enzyme/_coenzyme1.41618861
34MP0005501_abnormal_skin_physiology1.40923231
35MP0003303_peritoneal_inflammation1.38651409
36MP0005451_abnormal_body_composition1.37600798
37MP0005666_abnormal_adipose_tissue1.36529787
38MP0000604_amyloidosis1.34966087
39MP0002138_abnormal_hepatobiliary_system1.34833729
40MP0004019_abnormal_vitamin_homeostasis1.33098865
41MP0002419_abnormal_innate_immunity1.32538904
42MP0010234_abnormal_vibrissa_follicle1.31677377
43MP0004130_abnormal_muscle_cell1.31543013
44MP0001835_abnormal_antigen_presentation1.30420167
45MP0005025_abnormal_response_to1.30077252
46MP0010368_abnormal_lymphatic_system1.27064468
47MP0010155_abnormal_intestine_physiology1.26138795
48MP0002998_abnormal_bone_remodeling1.21021640
49MP0005584_abnormal_enzyme/coenzyme_acti1.20798106
50MP0004272_abnormal_basement_membrane1.20109783
51MP0000685_abnormal_immune_system1.17157298
52MP0001216_abnormal_epidermal_layer1.13231308
53MP0000490_abnormal_crypts_of1.12152168
54MP0004233_abnormal_muscle_weight1.11485707
55MP0005275_abnormal_skin_tensile1.11086494
56MP0003183_abnormal_peptide_metabolism1.11055389
57MP0001958_emphysema1.10468628
58MP0005000_abnormal_immune_tolerance1.08158278
59MP0000678_abnormal_parathyroid_gland1.07609962
60MP0003763_abnormal_thymus_physiology1.06442288
61MP0004510_myositis1.05919333
62MP0000598_abnormal_liver_morphology1.05672737
63MP0003329_amyloid_beta_deposits1.05266051
64MP0003453_abnormal_keratinocyte_physiol1.04339098
65MP0005023_abnormal_wound_healing1.04221028
66MP0004084_abnormal_cardiac_muscle1.03799547
67MP0005167_abnormal_blood-brain_barrier1.03177481
68MP0001790_abnormal_immune_system1.02365052
69MP0005387_immune_system_phenotype1.02365052
70MP0001853_heart_inflammation1.00523037
71MP0003448_altered_tumor_morphology1.00358507
72MP0004381_abnormal_hair_follicle1.00135760
73MP0002148_abnormal_hypersensitivity_rea0.99439347
74MP0005375_adipose_tissue_phenotype0.98360162
75MP0006054_spinal_hemorrhage0.98314849
76MP0003690_abnormal_glial_cell0.97655815
77MP0005330_cardiomyopathy0.96790238
78MP0009785_altered_susceptibility_to0.96497412
79MP0002098_abnormal_vibrissa_morphology0.96388153
80MP0000537_abnormal_urethra_morphology0.95645678
81MP0002452_abnormal_antigen_presenting0.95411883
82MP0005670_abnormal_white_adipose0.94477105
83MP0004782_abnormal_surfactant_physiolog0.94446196
84MP0002089_abnormal_postnatal_growth/wei0.94186630
85MP0002796_impaired_skin_barrier0.93188741
86MP0003656_abnormal_erythrocyte_physiolo0.91817966
87MP0001849_ear_inflammation0.91310897
88MP0001873_stomach_inflammation0.90970895
89MP0004808_abnormal_hematopoietic_stem0.90498563
90MP0009931_abnormal_skin_appearance0.89134098
91MP0001756_abnormal_urination0.88795154
92MP0002396_abnormal_hematopoietic_system0.88765787
93MP0001819_abnormal_immune_cell0.87752133
94MP0002723_abnormal_immune_serum0.86920328
95MP0002420_abnormal_adaptive_immunity0.86739580
96MP0001348_abnormal_lacrimal_gland0.86726810
97MP0004947_skin_inflammation0.86335224
98MP0002971_abnormal_brown_adipose0.83448413
99MP0004087_abnormal_muscle_fiber0.83029898
100MP0002136_abnormal_kidney_physiology0.82989866
101MP0002896_abnormal_bone_mineralization0.82400849
102MP0009384_cardiac_valve_regurgitation0.81292633
103MP0001800_abnormal_humoral_immune0.81086406
104MP0003724_increased_susceptibility_to0.81001393
105MP0001845_abnormal_inflammatory_respons0.80906113
106MP0000377_abnormal_hair_follicle0.80800532
107MP0000747_muscle_weakness0.80722461
108MP0004043_abnormal_pH_regulation0.80543303
109MP0003868_abnormal_feces_composition0.80503522
110MP0003828_pulmonary_edema0.80106126
111MP0010352_gastrointestinal_tract_polyps0.79924511
112MP0010630_abnormal_cardiac_muscle0.79180213
113MP0003186_abnormal_redox_activity0.78827855
114MP0002837_dystrophic_cardiac_calcinosis0.78745320
115MP0005621_abnormal_cell_physiology0.78356963
116MP0006082_CNS_inflammation0.77475869
117MP0002166_altered_tumor_susceptibility0.77053548
118MP0003221_abnormal_cardiomyocyte_apopto0.76910566
119MP0009763_increased_sensitivity_to0.76240570
120MP0008469_abnormal_protein_level0.75836021
121MP0005464_abnormal_platelet_physiology0.75758033
122MP0002060_abnormal_skin_morphology0.75490206
123MP0003950_abnormal_plasma_membrane0.74731769
124MP0001915_intracranial_hemorrhage0.74024983
125MP0001851_eye_inflammation0.73808948
126MP0005390_skeleton_phenotype0.73501695
127MP0000477_abnormal_intestine_morphology0.73198382
128MP0004036_abnormal_muscle_relaxation0.72736978
129MP0003279_aneurysm0.71924293
130MP0000343_altered_response_to0.71826072
131MP0003436_decreased_susceptibility_to0.71293493
132MP0002398_abnormal_bone_marrow0.71143226
133MP0009053_abnormal_anal_canal0.71120087
134MP0003075_altered_response_to0.70537279
135MP0002405_respiratory_system_inflammati0.69947630
136MP0000716_abnormal_immune_system0.69694166
137MP0002269_muscular_atrophy0.67950260
138MP0000249_abnormal_blood_vessel0.66725813
139MP0000920_abnormal_myelination0.65577607
140MP0005636_abnormal_mineral_homeostasis0.65319174
141MP0004264_abnormal_extraembryonic_tissu0.65183389
142MP0001533_abnormal_skeleton_physiology0.64756494
143MP0000750_abnormal_muscle_regeneration0.64038690
144MP0003091_abnormal_cell_migration0.63534553
145MP0000467_abnormal_esophagus_morphology0.63256749
146MP0009642_abnormal_blood_homeostasis0.63143128
147MP0001243_abnormal_dermal_layer0.62584788
148MP0005408_hypopigmentation0.61595029
149MP0008961_abnormal_basal_metabolism0.61102472
150MP0005165_increased_susceptibility_to0.60725704
151MP0000003_abnormal_adipose_tissue0.59996695
152MP0001544_abnormal_cardiovascular_syste0.58653155
153MP0005385_cardiovascular_system_phenoty0.58653155
154MP0002254_reproductive_system_inflammat0.58636662
155MP0002128_abnormal_blood_circulation0.58340640
156MP0000767_abnormal_smooth_muscle0.57944420
157MP0001661_extended_life_span0.57925241
158MP0000465_gastrointestinal_hemorrhage0.57644388
159MP0009278_abnormal_bone_marrow0.57225559

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.14318301
2Xanthomatosis (HP:0000991)4.60960961
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.42710030
4Intrahepatic cholestasis (HP:0001406)4.20829277
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.83731602
6Hyperlipoproteinemia (HP:0010980)3.57112937
7Complement deficiency (HP:0004431)3.46675397
8Vertebral compression fractures (HP:0002953)3.35798364
9Hyperammonemia (HP:0001987)3.28662814
10Ketosis (HP:0001946)3.25799016
11Hypoglycemic coma (HP:0001325)3.16966007
12Hypobetalipoproteinemia (HP:0003563)3.10158052
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.08924599
14Abnormality of liposaccharide metabolism (HP:0010968)3.05802031
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.05802031
16Abnormality of glycolipid metabolism (HP:0010969)3.05802031
17Abnormality of fatty-acid metabolism (HP:0004359)2.92785956
18Abnormality of glycine metabolism (HP:0010895)2.88627139
19Abnormality of serine family amino acid metabolism (HP:0010894)2.88627139
20Hyperacusis (HP:0010780)2.84164130
21Hyperglycinuria (HP:0003108)2.82466267
22Abnormality of sulfur amino acid metabolism (HP:0004339)2.80484662
23Eczematoid dermatitis (HP:0000976)2.79217228
24Asymmetry of the thorax (HP:0001555)2.75492959
25Myocardial infarction (HP:0001658)2.74719401
26Ketoacidosis (HP:0001993)2.73912510
27Abnormality of complement system (HP:0005339)2.73587558
28Flat acetabular roof (HP:0003180)2.70997178
29Abnormality of the common coagulation pathway (HP:0010990)2.70184809
30Hypoalphalipoproteinemia (HP:0003233)2.70066043
31Hypolipoproteinemia (HP:0010981)2.68679978
32Epidermoid cyst (HP:0200040)2.62832966
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61983132
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.61888006
35Thin bony cortex (HP:0002753)2.57683340
36Systemic lupus erythematosus (HP:0002725)2.57295637
37Prolonged partial thromboplastin time (HP:0003645)2.48993603
38Premature rupture of membranes (HP:0001788)2.46833961
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45679319
40Esophageal varix (HP:0002040)2.45202681
41Hypercholesterolemia (HP:0003124)2.44754082
42Joint hemorrhage (HP:0005261)2.41344387
43Distal lower limb muscle weakness (HP:0009053)2.39774809
44Spastic diplegia (HP:0001264)2.39768855
45Peritonitis (HP:0002586)2.39032002
46Hyperglycinemia (HP:0002154)2.37498269
47Abnormality of macrophages (HP:0004311)2.37335152
48Protrusio acetabuli (HP:0003179)2.35339740
49Axonal loss (HP:0003447)2.34936600
50Fat malabsorption (HP:0002630)2.33052373
51Polycythemia (HP:0001901)2.32323877
52Loss of speech (HP:0002371)2.32065737
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.30283907
54Right ventricular cardiomyopathy (HP:0011663)2.28466722
55Gout (HP:0001997)2.27811745
56Skin nodule (HP:0200036)2.25312482
57Abnormality of the intrinsic pathway (HP:0010989)2.24511743
58Abnormality of the Achilles tendon (HP:0005109)2.24283246
59Interstitial pulmonary disease (HP:0006530)2.24264344
60J-shaped sella turcica (HP:0002680)2.22872341
61Hyperparathyroidism (HP:0000843)2.22526319
62Abnormality of purine metabolism (HP:0004352)2.22195615
63Cerebral aneurysm (HP:0004944)2.21585048
64Myoglobinuria (HP:0002913)2.20332452
65Back pain (HP:0003418)2.19651832
66Abnormality of the distal phalanges of the toes (HP:0010182)2.19465515
67Asymmetric septal hypertrophy (HP:0001670)2.18586085
68Broad face (HP:0000283)2.17789982
69Vascular calcification (HP:0004934)2.17595837
70Dicarboxylic aciduria (HP:0003215)2.17373523
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17373523
72Cardiovascular calcification (HP:0011915)2.14143121
73Abnormal cartilage morphology (HP:0002763)2.13473164
74Distal lower limb amyotrophy (HP:0008944)2.12242746
75Recurrent abscess formation (HP:0002722)2.11804092
76Dysostosis multiplex (HP:0000943)2.11039652
77Abnormality of methionine metabolism (HP:0010901)2.09592768
78Hemorrhage of the eye (HP:0011885)2.09026112
79Bone pain (HP:0002653)2.06815164
80Polygenic inheritance (HP:0010982)2.06350303
81Broad metatarsal (HP:0001783)2.06273631
82Abnormality of the thoracic spine (HP:0100711)2.05836864
83Vacuolated lymphocytes (HP:0001922)2.05708448
84Cellulitis (HP:0100658)2.04698991
85Late onset (HP:0003584)2.04002425
86Centrally nucleated skeletal muscle fibers (HP:0003687)2.03408865
87Lymphangioma (HP:0100764)2.03089996
88Osteolytic defects of the phalanges of the hand (HP:0009771)2.02506936
89Osteolytic defects of the hand bones (HP:0009699)2.02506936
90Hydroxyprolinuria (HP:0003080)2.01583233
91Abnormality of proline metabolism (HP:0010907)2.01583233
92Hyporeflexia of lower limbs (HP:0002600)2.01408048
93Malnutrition (HP:0004395)1.99718181
94Cervical subluxation (HP:0003308)1.99475743
95Spinal cord lesions (HP:0100561)1.99028422
96Syringomyelia (HP:0003396)1.99028422
97Hepatocellular carcinoma (HP:0001402)1.98891007
98Mucopolysacchariduria (HP:0008155)1.98787241
99Urinary glycosaminoglycan excretion (HP:0003541)1.98787241
100Mitral stenosis (HP:0001718)1.97521842
101Cholelithiasis (HP:0001081)1.96165432
102Glomerulonephritis (HP:0000099)1.94499996
103Visceral angiomatosis (HP:0100761)1.92798327
104Colitis (HP:0002583)1.92795064
105Recurrent bacterial skin infections (HP:0005406)1.91828279
106Ileus (HP:0002595)1.91559923
107Abnormality of nucleobase metabolism (HP:0010932)1.90810357
108Abnormal gallbladder morphology (HP:0012437)1.89612848
109Segmental peripheral demyelination/remyelination (HP:0003481)1.88785217
110Amyloidosis (HP:0011034)1.87801194
111Cerebral inclusion bodies (HP:0100314)1.86476696
112Ulnar bowing (HP:0003031)1.86334534
113Increased connective tissue (HP:0009025)1.86222409
114Achilles tendon contracture (HP:0001771)1.85983228
115Thoracic kyphosis (HP:0002942)1.83819582
116Neurofibrillary tangles (HP:0002185)1.83356503
117Abnormality of iron homeostasis (HP:0011031)1.83176181
118Short nail (HP:0001799)1.82337380
119Aneurysm (HP:0002617)1.81180659
120Turricephaly (HP:0000262)1.80282806
121Cholecystitis (HP:0001082)1.80217151
122Abnormal gallbladder physiology (HP:0012438)1.80217151
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.80163628
124Purpura (HP:0000979)1.80089579
125Upper limb amyotrophy (HP:0009129)1.80026279
126Distal upper limb amyotrophy (HP:0007149)1.80026279
127Hyperbilirubinemia (HP:0002904)1.79866764
128Increased serum ferritin (HP:0003281)1.79542024
129Disproportionate tall stature (HP:0001519)1.79344709
130Blue sclerae (HP:0000592)1.79129723
131Muscle fiber splitting (HP:0003555)1.78775665
132Abnormality of transition element cation homeostasis (HP:0011030)1.78528857
133Increased cerebral lipofuscin (HP:0011813)1.78515901
134Hemangiomatosis (HP:0007461)1.78423215
135Nephritis (HP:0000123)1.77290905
136Abnormality of polysaccharide metabolism (HP:0011012)1.77067649
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77067649
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77067649
139Long palpebral fissure (HP:0000637)1.75945718
140Trismus (HP:0000211)1.75166798
141Exercise-induced muscle cramps (HP:0003710)1.75022920
142Gingivitis (HP:0000230)1.73404239
143Pathologic fracture (HP:0002756)1.73266088
144Multiple lipomas (HP:0001012)1.72721270
145Nuclear cataract (HP:0100018)1.71748069
146Abdominal distention (HP:0003270)1.71316541
147Increased IgE level (HP:0003212)1.69160556
148Fragile skin (HP:0001030)1.67533812
149Mitral regurgitation (HP:0001653)1.66586266
150Hypercortisolism (HP:0001578)1.65991699
151Arterial tortuosity (HP:0005116)1.65594673
152Dilatation of the ascending aorta (HP:0005111)1.63804102
153Recurrent gram-negative bacterial infections (HP:0005420)1.63038112
154Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.62934480
155Abnormal ossification of hand bones (HP:0005921)1.61312639
156Micronodular cirrhosis (HP:0001413)1.61031831
157Neuronal loss in central nervous system (HP:0002529)1.59827422
158Deformed sella turcica (HP:0002681)1.59657008
159Gastrointestinal inflammation (HP:0004386)1.57702208
160Cupped ribs (HP:0000887)1.57002982
161Ankyloglossia (HP:0010296)1.56096603
162Insomnia (HP:0100785)1.55577226
163Abnormality of carpal bone ossification (HP:0006257)1.55187104
164Metaphyseal cupping (HP:0003021)1.54020929
165Spinal cord compression (HP:0002176)1.53204263
166Biconcave vertebral bodies (HP:0004586)1.52039705
167Vascular tortuosity (HP:0004948)1.51081376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.01172031
2PKN23.94397612
3ERN13.86790889
4PRPF4B3.48015109
5SMG13.15611396
6IRAK33.07602299
7BCKDK2.94346526
8EPHB12.85137984
9NME22.63233750
10SIK12.53065269
11TTN2.47760034
12EEF2K2.21069230
13PTK62.20308937
14FGFR42.13520742
15MAP3K102.03746454
16RIPK11.90622503
17LRRK21.66654246
18LATS11.58924832
19BMX1.54213767
20MET1.49753808
21TAOK21.46972478
22ICK1.46892299
23PDGFRA1.45075824
24CDK121.43489121
25TGFBR21.40368947
26MAP3K131.37450859
27PAK41.33335177
28MAP3K141.20350621
29WNK41.18819187
30IRAK41.18556520
31ARAF1.16167254
32KDR1.15461619
33SIK31.14713476
34STK101.12470286
35DDR21.11128504
36PTK21.10862653
37STK391.10714682
38MAP2K21.10074040
39KSR21.08884627
40FLT31.06852474
41MAP4K11.06107104
42MST1R1.06066794
43TBK11.05446549
44TYK21.04633005
45RPS6KB21.04233251
46RIPK41.03263741
47MAP2K30.98020836
48TAOK30.98006825
49TIE10.96306991
50CSK0.94238826
51CDC42BPA0.94055680
52PAK20.93605892
53CAMK1D0.87956824
54IRAK20.86443338
55JAK20.83873980
56GRK60.82818371
57PRKD10.82487962
58TESK20.82466054
59LATS20.82197440
60RET0.81498020
61NEK90.80930241
62MAP3K70.80612012
63FGFR20.80135414
64EPHA20.78713048
65DMPK0.77408856
66JAK10.76866107
67DYRK1B0.76472279
68CDK60.76103675
69LMTK20.74790795
70ILK0.74377346
71RPS6KA20.73786630
72MTOR0.72852446
73PRKD20.72007098
74MOS0.71854280
75MAPK110.71666556
76MAP3K30.71557464
77MARK20.70431743
78JAK30.69106489
79MAP3K80.68881078
80PDGFRB0.68875929
81PRKG20.68695485
82PIM20.66998407
83TYRO30.66691045
84PDPK10.66650338
85MAP3K110.66036049
86EPHB20.65975950
87TAOK10.65743510
88RPS6KC10.65665735
89RPS6KL10.65665735
90CSF1R0.64663762
91ALK0.63573515
92ERBB40.63036918
93PAK30.62091091
94GSK3A0.61173823
95PRKD30.59526878
96CDK70.58939689
97BRAF0.55664787
98PRKAA20.55071166
99STK30.55008790
100MAP3K60.54446895
101PIK3CG0.53927300
102CAMK1G0.53539132
103HIPK20.51477677
104FGFR10.51407137
105ITK0.50708058
106EPHA30.50281945
107PRKCH0.48913999
108MAP3K10.47823616
109MAP2K10.47737610
110ZAP700.46817577
111ABL20.46715724
112OXSR10.46400246
113CDK40.46077464
114MAPKAPK20.45796790
115TRPM70.45353663
116FGFR30.45342393
117MAPKAPK30.44084100
118MAP3K20.43713693
119TESK10.43283683
120FGR0.42860175
121LIMK10.42120124
122SCYL20.41992323
123NTRK10.41778018
124FER0.40479195
125RPS6KA60.40106592
126HCK0.39439926
127IKBKE0.38963804
128PDK10.38639478
129ROCK20.38437484
130NEK10.38146215
131BTK0.37275245
132DAPK30.36574913
133BLK0.36390099
134ERBB20.36329361
135MELK0.36224009
136MATK0.34321922
137MAP3K90.32748104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.43844601
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.05408670
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94211172
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83778744
5Fatty acid degradation_Homo sapiens_hsa000712.72973158
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54952978
7Arginine biosynthesis_Homo sapiens_hsa002202.53892546
8Tryptophan metabolism_Homo sapiens_hsa003802.36087329
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34794375
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33035373
11Fatty acid metabolism_Homo sapiens_hsa012122.11725259
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10734735
13Acute myeloid leukemia_Homo sapiens_hsa052212.06533515
14Propanoate metabolism_Homo sapiens_hsa006402.05175500
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03082239
16Complement and coagulation cascades_Homo sapiens_hsa046102.02984628
17Butanoate metabolism_Homo sapiens_hsa006501.99837304
18PPAR signaling pathway_Homo sapiens_hsa033201.98400297
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90269063
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89824040
21Non-small cell lung cancer_Homo sapiens_hsa052231.75617562
22Histidine metabolism_Homo sapiens_hsa003401.70484213
23Pancreatic cancer_Homo sapiens_hsa052121.69985952
24Caffeine metabolism_Homo sapiens_hsa002321.67978815
25B cell receptor signaling pathway_Homo sapiens_hsa046621.66406158
26Staphylococcus aureus infection_Homo sapiens_hsa051501.61135781
27Peroxisome_Homo sapiens_hsa041461.60824595
28Osteoclast differentiation_Homo sapiens_hsa043801.58671027
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53412709
30Fatty acid elongation_Homo sapiens_hsa000621.52382016
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49465862
32beta-Alanine metabolism_Homo sapiens_hsa004101.49411421
33Bile secretion_Homo sapiens_hsa049761.49396061
34Thyroid cancer_Homo sapiens_hsa052161.49116317
35Carbon metabolism_Homo sapiens_hsa012001.47220837
36Fat digestion and absorption_Homo sapiens_hsa049751.46821372
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46385515
38Leishmaniasis_Homo sapiens_hsa051401.45358721
39Endometrial cancer_Homo sapiens_hsa052131.39826250
40Sulfur metabolism_Homo sapiens_hsa009201.37369977
41Selenocompound metabolism_Homo sapiens_hsa004501.36300838
42Hepatitis C_Homo sapiens_hsa051601.33549073
43Biosynthesis of amino acids_Homo sapiens_hsa012301.31504997
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30527429
45Pyruvate metabolism_Homo sapiens_hsa006201.29642867
46Chemical carcinogenesis_Homo sapiens_hsa052041.29338073
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28896588
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26779666
49Starch and sucrose metabolism_Homo sapiens_hsa005001.23411444
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.19666630
51Hepatitis B_Homo sapiens_hsa051611.19280955
52Influenza A_Homo sapiens_hsa051641.19110223
53* Notch signaling pathway_Homo sapiens_hsa043301.18597412
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18467324
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18392251
56Lysine degradation_Homo sapiens_hsa003101.11863442
57Apoptosis_Homo sapiens_hsa042101.10301826
58Folate biosynthesis_Homo sapiens_hsa007901.10157582
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.07958773
60Tuberculosis_Homo sapiens_hsa051521.07388612
61Arginine and proline metabolism_Homo sapiens_hsa003301.06914373
62TNF signaling pathway_Homo sapiens_hsa046681.06061516
63Shigellosis_Homo sapiens_hsa051311.04926541
64Phenylalanine metabolism_Homo sapiens_hsa003601.04829482
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04624109
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01672567
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.01289011
68Retinol metabolism_Homo sapiens_hsa008300.96964053
69Glioma_Homo sapiens_hsa052140.96084730
70Steroid biosynthesis_Homo sapiens_hsa001000.95509252
71ABC transporters_Homo sapiens_hsa020100.95496249
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93928554
73Prolactin signaling pathway_Homo sapiens_hsa049170.93474660
74Salmonella infection_Homo sapiens_hsa051320.92373926
75ErbB signaling pathway_Homo sapiens_hsa040120.91135557
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.90076799
77Pertussis_Homo sapiens_hsa051330.89539393
78mTOR signaling pathway_Homo sapiens_hsa041500.89090389
79Prostate cancer_Homo sapiens_hsa052150.88840762
80Measles_Homo sapiens_hsa051620.87694431
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87691363
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86868186
83Sulfur relay system_Homo sapiens_hsa041220.86181785
84Vibrio cholerae infection_Homo sapiens_hsa051100.85780155
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.85646651
86Herpes simplex infection_Homo sapiens_hsa051680.85360335
87Viral myocarditis_Homo sapiens_hsa054160.85090597
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84197810
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.81440126
90Glycerolipid metabolism_Homo sapiens_hsa005610.81311730
91Endocytosis_Homo sapiens_hsa041440.81147584
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.81064255
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80417582
94Colorectal cancer_Homo sapiens_hsa052100.80093445
95Pentose phosphate pathway_Homo sapiens_hsa000300.79936586
96HTLV-I infection_Homo sapiens_hsa051660.79670978
97Tyrosine metabolism_Homo sapiens_hsa003500.79409314
98Vitamin digestion and absorption_Homo sapiens_hsa049770.79084605
99HIF-1 signaling pathway_Homo sapiens_hsa040660.75883883
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74899515
101T cell receptor signaling pathway_Homo sapiens_hsa046600.74642969
102Viral carcinogenesis_Homo sapiens_hsa052030.73990158
103Lysosome_Homo sapiens_hsa041420.73420544
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73000019
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.72500303
106Insulin resistance_Homo sapiens_hsa049310.72006287
107Glutathione metabolism_Homo sapiens_hsa004800.71445666
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71186545
109Malaria_Homo sapiens_hsa051440.71018354
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.70647747
111Phagosome_Homo sapiens_hsa041450.69930702
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.69461037
113Estrogen signaling pathway_Homo sapiens_hsa049150.69083306
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.68391330
115Chemokine signaling pathway_Homo sapiens_hsa040620.68336563
116Antigen processing and presentation_Homo sapiens_hsa046120.68142082
117MicroRNAs in cancer_Homo sapiens_hsa052060.67925891
118Choline metabolism in cancer_Homo sapiens_hsa052310.66484411
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64841083
120Legionellosis_Homo sapiens_hsa051340.63119335
121GnRH signaling pathway_Homo sapiens_hsa049120.62993032
122Sphingolipid metabolism_Homo sapiens_hsa006000.61458675
123N-Glycan biosynthesis_Homo sapiens_hsa005100.61011832
124Fatty acid biosynthesis_Homo sapiens_hsa000610.60217779
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55750506
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54928922
127Inositol phosphate metabolism_Homo sapiens_hsa005620.54717802
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53212884
129Epstein-Barr virus infection_Homo sapiens_hsa051690.53181012
130ECM-receptor interaction_Homo sapiens_hsa045120.52833084
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52588190
132Allograft rejection_Homo sapiens_hsa053300.52563516
133Other glycan degradation_Homo sapiens_hsa005110.50967444
134Bladder cancer_Homo sapiens_hsa052190.47604009
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47393330
136Amoebiasis_Homo sapiens_hsa051460.47111004
137Focal adhesion_Homo sapiens_hsa045100.45431553
138Protein digestion and absorption_Homo sapiens_hsa049740.42794667
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.40965311
140AMPK signaling pathway_Homo sapiens_hsa041520.40744102
141Galactose metabolism_Homo sapiens_hsa000520.40114012
142Prion diseases_Homo sapiens_hsa050200.39900929
143Vitamin B6 metabolism_Homo sapiens_hsa007500.38694690
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38402474
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37913402
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.37129512
147Fructose and mannose metabolism_Homo sapiens_hsa000510.32609317
148Proteoglycans in cancer_Homo sapiens_hsa052050.31379097
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30441387
150Chronic myeloid leukemia_Homo sapiens_hsa052200.28922297
151Renin-angiotensin system_Homo sapiens_hsa046140.28578853
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28408593
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27253144
154Small cell lung cancer_Homo sapiens_hsa052220.26742988
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26606622
156Renal cell carcinoma_Homo sapiens_hsa052110.24441398
157Toxoplasmosis_Homo sapiens_hsa051450.19584363
158Metabolic pathways_Homo sapiens_hsa011000.19140251
159One carbon pool by folate_Homo sapiens_hsa006700.18749870
160Insulin signaling pathway_Homo sapiens_hsa049100.18671731
161Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16342464
162Mineral absorption_Homo sapiens_hsa049780.15731781
163VEGF signaling pathway_Homo sapiens_hsa043700.15473009
164Adherens junction_Homo sapiens_hsa045200.14878221
165Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14499039
166Tight junction_Homo sapiens_hsa045300.13264000

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