APH1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.74557031
2synaptic vesicle exocytosis (GO:0016079)4.33238322
3locomotory exploration behavior (GO:0035641)4.17789738
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13659726
5neutrophil activation involved in immune response (GO:0002283)4.13591846
6presynaptic membrane assembly (GO:0097105)4.10199937
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02419113
8negative regulation of cell killing (GO:0031342)4.02419113
9vocalization behavior (GO:0071625)3.99609028
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.98978596
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86841089
12neuron recognition (GO:0008038)3.82854226
13regulation of synaptic vesicle exocytosis (GO:2000300)3.82311767
14macrophage activation involved in immune response (GO:0002281)3.81139159
15neurotransmitter-gated ion channel clustering (GO:0072578)3.78126633
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72612899
17protein localization to synapse (GO:0035418)3.72371972
18presynaptic membrane organization (GO:0097090)3.69860549
19axonal fasciculation (GO:0007413)3.69536572
20postsynaptic membrane organization (GO:0001941)3.67943818
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.66407996
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.63468844
23positive regulation of gamma-delta T cell activation (GO:0046645)3.63152267
24cellular extravasation (GO:0045123)3.62928649
25positive regulation by symbiont of host defense response (GO:0052509)3.61461476
26modulation by symbiont of host defense response (GO:0052031)3.61461476
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.61461476
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.61461476
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.61461476
30modulation by symbiont of host immune response (GO:0052553)3.61461476
31positive regulation of cellular amide metabolic process (GO:0034250)3.59609898
32glutamate secretion (GO:0014047)3.57237126
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.55259116
34microglial cell activation (GO:0001774)3.54348563
35synaptic vesicle maturation (GO:0016188)3.52620064
36regulation of glutamate receptor signaling pathway (GO:1900449)3.48603736
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.45386527
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39605124
39exploration behavior (GO:0035640)3.38084929
40glutamate receptor signaling pathway (GO:0007215)3.36442996
41cerebral cortex radially oriented cell migration (GO:0021799)3.35629674
42cerebellar granule cell differentiation (GO:0021707)3.33629212
43neuron-neuron synaptic transmission (GO:0007270)3.26586738
44synaptic transmission, glutamatergic (GO:0035249)3.25884913
45macrophage activation (GO:0042116)3.25099198
46antigen processing and presentation of endogenous antigen (GO:0019883)3.24906820
47inositol phosphate catabolic process (GO:0071545)3.24903983
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.24128464
49regulation of beta-amyloid formation (GO:1902003)3.24107822
50inositol phosphate dephosphorylation (GO:0046855)3.22924480
51phosphorylated carbohydrate dephosphorylation (GO:0046838)3.22924480
52neuronal action potential propagation (GO:0019227)3.22510052
53regulation of synaptic vesicle transport (GO:1902803)3.20677237
54layer formation in cerebral cortex (GO:0021819)3.20594807
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.19821465
56dendrite morphogenesis (GO:0048813)3.18777990
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18352373
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.16704496
59neurotransmitter secretion (GO:0007269)3.16226410
60regulation of interferon-beta biosynthetic process (GO:0045357)3.15883964
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12719674
62adaptation of signaling pathway (GO:0023058)3.08241368
63detection of molecule of bacterial origin (GO:0032490)3.07977633
64regulation of B cell receptor signaling pathway (GO:0050855)3.07425736
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04499811
66regulation of neuronal synaptic plasticity (GO:0048168)3.04356891
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02659521
68response to host immune response (GO:0052572)3.02659521
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01988445
70N-acetylneuraminate metabolic process (GO:0006054)3.00574498
71long-term synaptic potentiation (GO:0060291)2.98032241
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97015084
73dendritic spine morphogenesis (GO:0060997)2.96022166
74response to peptidoglycan (GO:0032494)2.94202097
75negative regulation of interleukin-12 production (GO:0032695)2.91011287
76regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90664217
77proline transport (GO:0015824)2.90007555
78transmission of nerve impulse (GO:0019226)2.89578336
79negative regulation of neurotransmitter transport (GO:0051589)2.88249942
80production of molecular mediator involved in inflammatory response (GO:0002532)2.86376024
81positive regulation of mast cell activation (GO:0033005)2.86089776
82neutrophil activation (GO:0042119)2.85506046
83regulation of type B pancreatic cell apoptotic process (GO:2000674)2.85108368
84auditory behavior (GO:0031223)2.84121027
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83910024
86regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.83558518
87long-term memory (GO:0007616)2.83275660
88regulation of synapse structural plasticity (GO:0051823)2.82421362
89granulocyte activation (GO:0036230)2.79800604
90toxin transport (GO:1901998)2.78951446
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.78392152
92synaptic vesicle endocytosis (GO:0048488)2.78367381
93amino sugar catabolic process (GO:0046348)2.78234096
94regulation of postsynaptic membrane potential (GO:0060078)2.77949637
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77841185
96gamma-aminobutyric acid transport (GO:0015812)2.77624019
97mating behavior (GO:0007617)2.77055472
98central nervous system projection neuron axonogenesis (GO:0021952)2.76505682
99myeloid cell activation involved in immune response (GO:0002275)2.75896033
100axon ensheathment in central nervous system (GO:0032291)2.75793812
101central nervous system myelination (GO:0022010)2.75793812
102regulation of neurotransmitter secretion (GO:0046928)2.75262300
103macroautophagy (GO:0016236)2.74167495
104regulation of amyloid precursor protein catabolic process (GO:1902991)2.73948189
105regulation of vesicle fusion (GO:0031338)2.72562960
106L-amino acid import (GO:0043092)2.72220890
107neurotransmitter transport (GO:0006836)2.71277127
108positive regulation of membrane potential (GO:0045838)2.70334051
109synapse assembly (GO:0007416)2.69280395
110oligosaccharide catabolic process (GO:0009313)2.68951328
111regulation of extracellular matrix disassembly (GO:0010715)2.66111905
112response to auditory stimulus (GO:0010996)2.65742841
113regulation of dendritic spine morphogenesis (GO:0061001)2.65712413
114positive regulation of synapse assembly (GO:0051965)2.65642891
115positive regulation of mast cell activation involved in immune response (GO:0033008)2.65324538
116positive regulation of mast cell degranulation (GO:0043306)2.65324538
117cellular potassium ion homeostasis (GO:0030007)2.63217213
118polyol catabolic process (GO:0046174)2.62701026
119long-chain fatty acid biosynthetic process (GO:0042759)2.62339455
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61095909
121innervation (GO:0060384)2.60271914
122positive regulation of neurotransmitter secretion (GO:0001956)2.60012635
123antigen processing and presentation via MHC class Ib (GO:0002475)2.59806980
124protein targeting to Golgi (GO:0000042)2.58805407
125axoneme assembly (GO:0035082)2.58616601
126membrane assembly (GO:0071709)2.58434988
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57039609
128positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.56593957
129mechanosensory behavior (GO:0007638)2.56119169
130phagosome maturation (GO:0090382)2.54967431
131regulation of neurotransmitter transport (GO:0051588)2.54950734
132regulation of glutamate secretion (GO:0014048)2.53804862
133positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53437699
134regulation of synaptic plasticity (GO:0048167)2.52334093
135regulation of dendritic spine development (GO:0060998)2.51836086
136response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51509354
137response to host (GO:0075136)2.51509354
138response to host defenses (GO:0052200)2.51509354
139cerebellar Purkinje cell differentiation (GO:0021702)2.50895155
140behavioral response to cocaine (GO:0048148)2.50684292
141retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50183426
142neuron remodeling (GO:0016322)2.49193937
143regulation of gamma-delta T cell activation (GO:0046643)2.48968599
144negative regulation of lymphocyte mediated immunity (GO:0002707)2.48204514
145establishment of protein localization to Golgi (GO:0072600)2.48071023
146B cell receptor signaling pathway (GO:0050853)2.48061635
147regulation of mast cell degranulation (GO:0043304)2.47541214
148membrane hyperpolarization (GO:0060081)2.46629573
149pyrimidine nucleobase catabolic process (GO:0006208)2.46116823
150amino acid import (GO:0043090)2.45660113
151adult walking behavior (GO:0007628)2.45382606
152amyloid precursor protein catabolic process (GO:0042987)2.45241692
153response to histamine (GO:0034776)2.45125925
154synapse organization (GO:0050808)2.45010840
155negative regulation of dendrite development (GO:2000171)2.44850660
156respiratory burst (GO:0045730)2.44126602
157positive regulation of macroautophagy (GO:0016239)2.43436574
158detection of external biotic stimulus (GO:0098581)2.43243442
159regulation of platelet aggregation (GO:0090330)2.42731374
160regulation of synaptic transmission, GABAergic (GO:0032228)2.42639951
161histamine secretion (GO:0001821)2.42402846
162regulation of neurotransmitter levels (GO:0001505)2.42142738
163lytic vacuole organization (GO:0080171)2.41896449
164lysosome organization (GO:0007040)2.41896449
165negative regulation of axon extension (GO:0030517)2.40984447
166learning (GO:0007612)2.40676314
167detection of other organism (GO:0098543)2.39640602
168energy homeostasis (GO:0097009)2.39579997
169central nervous system neuron axonogenesis (GO:0021955)2.39308016
170nitric oxide mediated signal transduction (GO:0007263)2.38843749
171regulation of protein glycosylation (GO:0060049)2.38723642
172negative regulation of synaptic transmission (GO:0050805)2.38248234
173membrane depolarization (GO:0051899)2.38066284
174negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.37911103
175negative regulation of interleukin-6 production (GO:0032715)2.37759157
176synaptic vesicle transport (GO:0048489)2.37723411
177establishment of synaptic vesicle localization (GO:0097480)2.37723411
178regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37239427
179regulation of mast cell activation (GO:0033003)2.36704983
180import into cell (GO:0098657)2.36039303
181negative regulation of interleukin-17 production (GO:0032700)2.35669455
182regulation of mast cell activation involved in immune response (GO:0033006)2.35609200
183neutrophil mediated immunity (GO:0002446)2.35100988
184regulation of memory T cell differentiation (GO:0043380)2.32278766
185positive regulation of B cell differentiation (GO:0045579)2.31789640
186L-alpha-amino acid transmembrane transport (GO:1902475)2.28193068
187regulation of cilium movement (GO:0003352)2.27992960
188positive regulation of leukocyte degranulation (GO:0043302)2.27975390
189negative regulation of glycoprotein biosynthetic process (GO:0010561)2.27728079
190potassium ion export (GO:0071435)2.26881763
191regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.23364178
192immunoglobulin mediated immune response (GO:0016064)2.23035868
193positive regulation of macrophage cytokine production (GO:0060907)2.22800063
194regulation of natural killer cell mediated immunity (GO:0002715)2.22419355
195regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.22419355
196negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.22043184
197negative regulation of execution phase of apoptosis (GO:1900118)2.21955405
198cellular ketone body metabolic process (GO:0046950)2.21201830
199early endosome to late endosome transport (GO:0045022)2.21199140
200negative regulation of bone resorption (GO:0045779)2.20985581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.57024211
2GBX2_23144817_ChIP-Seq_PC3_Human3.73896836
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.68587750
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27362741
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20937231
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.95318251
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85636979
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80025795
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73990080
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49615119
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46463396
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44457458
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43551417
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43551417
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.42671272
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37187949
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35293503
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.34966682
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.34038413
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23542808
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21627127
22TAF15_26573619_Chip-Seq_HEK293_Human2.18151518
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16513550
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03640947
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.01069739
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.00569083
27AR_21572438_ChIP-Seq_LNCaP_Human1.99678047
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96191443
29IGF1R_20145208_ChIP-Seq_DFB_Human1.95808851
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88590272
31REST_21632747_ChIP-Seq_MESCs_Mouse1.88030909
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87557109
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84650082
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83170879
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79791188
36RUNX_20019798_ChIP-Seq_JUKART_Human1.75238620
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73568278
38DROSHA_22980978_ChIP-Seq_HELA_Human1.73282648
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73251043
40P300_19829295_ChIP-Seq_ESCs_Human1.72105499
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69527815
42VDR_24787735_ChIP-Seq_THP-1_Human1.69292034
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68476724
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66051612
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65956900
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65116371
47SMAD4_21799915_ChIP-Seq_A2780_Human1.65074104
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63407542
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63248430
50* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62781459
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61006300
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60050764
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.60039189
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60031744
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59289812
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55593516
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50985520
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49052383
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48377460
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.48338220
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47289194
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.46616252
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.44906380
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43601614
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.41350785
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41067159
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38001884
68VDR_22108803_ChIP-Seq_LS180_Human1.36763006
69SPI1_23127762_ChIP-Seq_K562_Human1.36555729
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.35744891
71FUS_26573619_Chip-Seq_HEK293_Human1.35634264
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35235387
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34029301
74AR_25329375_ChIP-Seq_VCAP_Human1.32609863
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30883293
76ER_23166858_ChIP-Seq_MCF-7_Human1.29992897
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27905226
78RNF2_27304074_Chip-Seq_NSC_Mouse1.27070693
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23882141
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.23016483
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22766739
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22539394
83TP53_18474530_ChIP-ChIP_U2OS_Human1.22443705
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.21681749
85SPI1_23547873_ChIP-Seq_NB4_Human1.19621565
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19487140
87STAT3_23295773_ChIP-Seq_U87_Human1.19237953
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.18148368
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17079891
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16157865
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15682693
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15561613
93ZNF274_21170338_ChIP-Seq_K562_Hela1.15233292
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.13893914
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13891917
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13198562
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13040158
98* GATA3_26560356_Chip-Seq_TH2_Human1.12614393
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11702390
100RUNX2_22187159_ChIP-Seq_PCA_Human1.10334625
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.10038757
102SCL_19346495_ChIP-Seq_HPC-7_Human1.09538270
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08187580
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08123170
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07796056
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07796056
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.07758598
108* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07391327
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.07148404
110GATA3_27048872_Chip-Seq_THYMUS_Human1.06194070
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.05967780
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05951783
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.04748562
114BCAT_22108803_ChIP-Seq_LS180_Human1.04588027
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04536607
116* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04505238
117TCF4_23295773_ChIP-Seq_U87_Human1.04077462
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03890525
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.03880753
120TP53_16413492_ChIP-PET_HCT116_Human1.02530604
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02210823
122AHR_22903824_ChIP-Seq_MCF-7_Human1.01578215
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01348251
124MYB_26560356_Chip-Seq_TH2_Human1.00760336
125SMRT_27268052_Chip-Seq_Bcells_Human1.00356441
126ERG_21242973_ChIP-ChIP_JURKAT_Human1.00129856
127AR_19668381_ChIP-Seq_PC3_Human0.99574499
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99514126
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99514126
130CDX2_22108803_ChIP-Seq_LS180_Human0.98627335
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98506368
132P53_22387025_ChIP-Seq_ESCs_Mouse0.98195822
133RXR_22108803_ChIP-Seq_LS180_Human0.98077052
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.97904932
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97773428
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97717301
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.97320932
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97088092
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96233195
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95951513
141JUN_21703547_ChIP-Seq_K562_Human0.95514959
142* TAL1_26923725_Chip-Seq_HPCs_Mouse0.94827708
143CMYC_18555785_Chip-Seq_ESCs_Mouse0.94572002
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94505057
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94411519
146TP63_23658742_ChIP-Seq_EP156T_Human0.94267333
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.93672343
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92557982
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.91614099
150SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91284591
151NANOG_19829295_ChIP-Seq_ESCs_Human0.89993450
152SOX2_19829295_ChIP-Seq_ESCs_Human0.89993450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.78656868
2MP0004859_abnormal_synaptic_plasticity4.70482092
3MP0003172_abnormal_lysosome_physiology3.70747623
4MP0004270_analgesia3.46588812
5MP0003635_abnormal_synaptic_transmissio3.42037464
6MP0003724_increased_susceptibility_to3.41102746
7MP0002254_reproductive_system_inflammat3.05157968
8MP0002063_abnormal_learning/memory/cond2.84176662
9MP0009745_abnormal_behavioral_response2.83426446
10MP0005058_abnormal_lysosome_morphology2.70934110
11MP0006082_CNS_inflammation2.69191937
12MP0002064_seizures2.68816481
13MP0005379_endocrine/exocrine_gland_phen2.61867411
14MP0001835_abnormal_antigen_presentation2.58351107
15MP0001968_abnormal_touch/_nociception2.57126665
16MP0003303_peritoneal_inflammation2.56060935
17MP0002734_abnormal_mechanical_nocicepti2.54051569
18MP0009046_muscle_twitch2.47970064
19MP0001486_abnormal_startle_reflex2.47569168
20MP0000778_abnormal_nervous_system2.43402171
21MP0002572_abnormal_emotion/affect_behav2.40184150
22MP0005464_abnormal_platelet_physiology2.37633004
23MP0009780_abnormal_chondrocyte_physiolo2.35206795
24MP0002272_abnormal_nervous_system2.34139900
25MP0006054_spinal_hemorrhage2.33348891
26MP0002736_abnormal_nociception_after2.22550003
27MP0000569_abnormal_digit_pigmentation2.21963164
28MP0001440_abnormal_grooming_behavior2.21619079
29MP0001984_abnormal_olfaction2.20662857
30MP0002735_abnormal_chemical_nociception2.14120260
31MP0000015_abnormal_ear_pigmentation2.11380009
32MP0005423_abnormal_somatic_nervous2.09666858
33MP0002419_abnormal_innate_immunity2.02826290
34MP0002184_abnormal_innervation1.96232800
35MP0003300_gastrointestinal_ulcer1.92792595
36MP0001501_abnormal_sleep_pattern1.91136420
37MP0003329_amyloid_beta_deposits1.89597845
38MP0004858_abnormal_nervous_system1.87479747
39MP0002067_abnormal_sensory_capabilities1.86082427
40MP0000685_abnormal_immune_system1.84802989
41MP0001970_abnormal_pain_threshold1.84231597
42MP0005646_abnormal_pituitary_gland1.83919039
43MP0005174_abnormal_tail_pigmentation1.83824112
44MP0005310_abnormal_salivary_gland1.82713361
45MP0003436_decreased_susceptibility_to1.82649451
46MP0002733_abnormal_thermal_nociception1.75665215
47MP0005387_immune_system_phenotype1.75477713
48MP0001790_abnormal_immune_system1.75477713
49MP0005671_abnormal_response_to1.73510245
50MP0006276_abnormal_autonomic_nervous1.73483005
51MP0005000_abnormal_immune_tolerance1.70450110
52MP0005171_absent_coat_pigmentation1.70368170
53MP0008569_lethality_at_weaning1.67613735
54MP0002557_abnormal_social/conspecific_i1.60420007
55MP0005645_abnormal_hypothalamus_physiol1.60285061
56MP0002148_abnormal_hypersensitivity_rea1.59812457
57MP0004742_abnormal_vestibular_system1.59638126
58MP0002693_abnormal_pancreas_physiology1.59598033
59MP0000955_abnormal_spinal_cord1.58380605
60MP0001533_abnormal_skeleton_physiology1.54544580
61MP0008877_abnormal_DNA_methylation1.53167347
62MP0000920_abnormal_myelination1.52063946
63MP0002452_abnormal_antigen_presenting1.51138613
64MP0002102_abnormal_ear_morphology1.50372253
65MP0001188_hyperpigmentation1.49965944
66MP0002723_abnormal_immune_serum1.47182122
67MP0008004_abnormal_stomach_pH1.44784738
68MP0004811_abnormal_neuron_physiology1.43476023
69MP0001502_abnormal_circadian_rhythm1.41914853
70MP0005386_behavior/neurological_phenoty1.41890603
71MP0004924_abnormal_behavior1.41890603
72MP0002882_abnormal_neuron_morphology1.41123956
73MP0009785_altered_susceptibility_to1.41023199
74MP0003283_abnormal_digestive_organ1.40377852
75MP0001800_abnormal_humoral_immune1.39072381
76MP0005025_abnormal_response_to1.37894641
77MP0003011_delayed_dark_adaptation1.37661251
78MP0001819_abnormal_immune_cell1.37537552
79MP0004885_abnormal_endolymph1.37456918
80MP0002420_abnormal_adaptive_immunity1.36965367
81MP0004883_abnormal_blood_vessel1.33024328
82MP0003634_abnormal_glial_cell1.31883026
83MP0002405_respiratory_system_inflammati1.30971006
84MP0003633_abnormal_nervous_system1.28943436
85MP0005397_hematopoietic_system_phenotyp1.26719109
86MP0001545_abnormal_hematopoietic_system1.26719109
87MP0002066_abnormal_motor_capabilities/c1.25077860
88MP0001529_abnormal_vocalization1.22805620
89MP0001905_abnormal_dopamine_level1.22681768
90MP0002163_abnormal_gland_morphology1.22043473
91MP0003690_abnormal_glial_cell1.18825237
92MP0002090_abnormal_vision1.18780738
93MP0005377_hearing/vestibular/ear_phenot1.17959274
94MP0003878_abnormal_ear_physiology1.17959274
95MP0005551_abnormal_eye_electrophysiolog1.17438410
96MP0003631_nervous_system_phenotype1.16387044
97MP0001845_abnormal_inflammatory_respons1.15325829
98MP0001299_abnormal_eye_distance/1.14819738
99MP0004142_abnormal_muscle_tone1.13405016
100MP0003195_calcinosis1.12166999
101MP0000631_abnormal_neuroendocrine_gland1.10467547
102MP0002998_abnormal_bone_remodeling1.09086699
103MP0001177_atelectasis1.08944708
104MP0001944_abnormal_pancreas_morphology1.07878412
105MP0004808_abnormal_hematopoietic_stem1.07820485
106MP0002152_abnormal_brain_morphology1.06944534
107MP0008469_abnormal_protein_level1.06591267
108MP0002876_abnormal_thyroid_physiology1.06582559
109MP0000371_diluted_coat_color1.05112738
110MP0005075_abnormal_melanosome_morpholog1.04956919
111MP0010386_abnormal_urinary_bladder1.04125248
112MP0001963_abnormal_hearing_physiology1.04034020
113MP0010234_abnormal_vibrissa_follicle1.01667534
114MP0000343_altered_response_to1.01009890
115MP0003656_abnormal_erythrocyte_physiolo1.00449660
116MP0003122_maternal_imprinting0.99266211
117MP0004510_myositis0.98172554
118MP0003045_fibrosis0.97711600
119MP0002295_abnormal_pulmonary_circulatio0.97358582
120MP0002166_altered_tumor_susceptibility0.97319871
121MP0000689_abnormal_spleen_morphology0.96692799
122MP0002752_abnormal_somatic_nervous0.95585690
123MP0002822_catalepsy0.95498156
124MP0003632_abnormal_nervous_system0.95159390
125MP0002928_abnormal_bile_duct0.94732883
126MP0002229_neurodegeneration0.93954595
127MP0003828_pulmonary_edema0.93212359
128MP0002909_abnormal_adrenal_gland0.91475131
129MP0010678_abnormal_skin_adnexa0.90320942
130MP0003879_abnormal_hair_cell0.89870257
131MP0003191_abnormal_cellular_cholesterol0.88051133
132MP0000716_abnormal_immune_system0.86907154
133MP0001485_abnormal_pinna_reflex0.86387346
134MP0000751_myopathy0.83968691
135MP0000372_irregular_coat_pigmentation0.83218075
136MP0002653_abnormal_ependyma_morphology0.83186111
137MP0001756_abnormal_urination0.82556597
138MP0006072_abnormal_retinal_apoptosis0.81815643
139MP0000604_amyloidosis0.81562543
140MP0003136_yellow_coat_color0.81398643
141MP0002837_dystrophic_cardiac_calcinosis0.80866215
142MP0004043_abnormal_pH_regulation0.80702298
143MP0001853_heart_inflammation0.80367797
144MP0005535_abnormal_body_temperature0.79583885
145MP0009764_decreased_sensitivity_to0.79533738
146MP0000013_abnormal_adipose_tissue0.79362220
147MP0005409_darkened_coat_color0.78886190
148MP0004019_abnormal_vitamin_homeostasis0.77745295
149MP0004134_abnormal_chest_morphology0.77081297
150MP0002078_abnormal_glucose_homeostasis0.76522513
151MP0002069_abnormal_eating/drinking_beha0.76461465
152MP0004145_abnormal_muscle_electrophysio0.76337453
153MP0005084_abnormal_gallbladder_morpholo0.76291751
154MP0003075_altered_response_to0.75335287
155MP0000639_abnormal_adrenal_gland0.74548107
156MP0001958_emphysema0.73798477
157MP0005595_abnormal_vascular_smooth0.73144934
158MP0000026_abnormal_inner_ear0.72635330
159MP0001943_abnormal_respiration0.70823250
160MP0003787_abnormal_imprinting0.70291919
161MP0003795_abnormal_bone_structure0.69783169
162MP0002009_preneoplasia0.68344505
163MP0005499_abnormal_olfactory_system0.68206130
164MP0005394_taste/olfaction_phenotype0.68206130
165MP0004085_abnormal_heartbeat0.66458943
166MP0003183_abnormal_peptide_metabolism0.66315235
167MP0005167_abnormal_blood-brain_barrier0.65223280
168MP0002751_abnormal_autonomic_nervous0.64496855
169MP0005187_abnormal_penis_morphology0.63697246
170MP0005253_abnormal_eye_physiology0.63549849
171MP0008874_decreased_physiological_sensi0.62913892
172MP0005195_abnormal_posterior_eye0.62096669
173MP0005623_abnormal_meninges_morphology0.61504114
174MP0001664_abnormal_digestion0.59857531
175MP0004484_altered_response_of0.59788373
176MP0005248_abnormal_Harderian_gland0.58768116

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.46481205
2Vacuolated lymphocytes (HP:0001922)4.73473090
3Abnormality of liposaccharide metabolism (HP:0010968)4.55294150
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.55294150
5Abnormality of glycolipid metabolism (HP:0010969)4.55294150
6Myokymia (HP:0002411)4.41685173
7Epileptic encephalopathy (HP:0200134)4.37655416
8Atonic seizures (HP:0010819)4.32812577
9Focal seizures (HP:0007359)4.25589127
10Visual hallucinations (HP:0002367)4.02009036
11Febrile seizures (HP:0002373)3.92791854
12Hematochezia (HP:0002573)3.89572286
13Progressive cerebellar ataxia (HP:0002073)3.85360245
14Dysostosis multiplex (HP:0000943)3.80390116
15Neurofibrillary tangles (HP:0002185)3.73277398
16Abnormality of macrophages (HP:0004311)3.68100615
17Abnormality of polysaccharide metabolism (HP:0011012)3.61440023
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.61440023
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.61440023
20Urinary glycosaminoglycan excretion (HP:0003541)3.59890700
21Mucopolysacchariduria (HP:0008155)3.59890700
22Absence seizures (HP:0002121)3.41133969
23Stomatitis (HP:0010280)3.39469387
24Recurrent bacterial skin infections (HP:0005406)3.38491123
25Hypoglycemic seizures (HP:0002173)3.36413402
26Hyperventilation (HP:0002883)3.35308688
27Action tremor (HP:0002345)3.35164920
28Recurrent abscess formation (HP:0002722)3.32976413
29Dialeptic seizures (HP:0011146)3.29287718
30Cerebral inclusion bodies (HP:0100314)3.25919999
31Increased CSF protein (HP:0002922)3.24750763
32Generalized tonic-clonic seizures (HP:0002069)3.19240884
33Supranuclear gaze palsy (HP:0000605)3.17912541
34Eczematoid dermatitis (HP:0000976)3.11044352
35Insidious onset (HP:0003587)3.05550868
36Termporal pattern (HP:0011008)3.05550868
37Limb dystonia (HP:0002451)3.02425060
38Mutism (HP:0002300)3.01544798
39Pheochromocytoma (HP:0002666)2.97981426
40Abnormality of the corticospinal tract (HP:0002492)2.91002989
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.85834417
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.85834417
43Broad-based gait (HP:0002136)2.80620665
44Elevated erythrocyte sedimentation rate (HP:0003565)2.77889914
45Dysdiadochokinesis (HP:0002075)2.72144500
46Loss of speech (HP:0002371)2.72119154
47Chronic otitis media (HP:0000389)2.71262575
48Neuroendocrine neoplasm (HP:0100634)2.68558810
49Cutaneous melanoma (HP:0012056)2.68470636
50Ketoacidosis (HP:0001993)2.64957347
51Gait imbalance (HP:0002141)2.63398433
52Ankle clonus (HP:0011448)2.60902973
53Polyphagia (HP:0002591)2.58907225
54Progressive neurologic deterioration (HP:0002344)2.58729098
55Dysmetria (HP:0001310)2.58549621
56Aplasia involving bones of the extremities (HP:0009825)2.56757249
57Aplasia involving bones of the upper limbs (HP:0009823)2.56757249
58Aplasia of the phalanges of the hand (HP:0009802)2.56757249
59Episodic fever (HP:0001954)2.55653416
60Absent speech (HP:0001344)2.55202275
61Megalencephaly (HP:0001355)2.52514206
62Abnormal eating behavior (HP:0100738)2.52030309
63Hemiparesis (HP:0001269)2.51245268
64Diplopia (HP:0000651)2.43480778
65Abnormality of binocular vision (HP:0011514)2.43480778
66True hermaphroditism (HP:0010459)2.41986906
67Amblyopia (HP:0000646)2.41843219
68Pancreatic fibrosis (HP:0100732)2.41474877
69Recurrent skin infections (HP:0001581)2.39720655
70Myositis (HP:0100614)2.39703407
71Hyperinsulinemic hypoglycemia (HP:0000825)2.35283374
72Drooling (HP:0002307)2.34760252
73Excessive salivation (HP:0003781)2.34760252
74Albinism (HP:0001022)2.32326104
75Prolonged bleeding time (HP:0003010)2.27372622
76Depression (HP:0000716)2.26510514
77Nephrogenic diabetes insipidus (HP:0009806)2.26076525
78Truncal ataxia (HP:0002078)2.26045427
79Cardiomegaly (HP:0001640)2.25946045
80Intention tremor (HP:0002080)2.22586240
81Urinary bladder sphincter dysfunction (HP:0002839)2.22068835
82Gingival bleeding (HP:0000225)2.21908913
83Symptomatic seizures (HP:0011145)2.21826597
84Recurrent gram-negative bacterial infections (HP:0005420)2.20452873
85Petechiae (HP:0000967)2.18933852
86Testicular neoplasm (HP:0010788)2.18731822
87Inappropriate behavior (HP:0000719)2.16799705
88Hypothermia (HP:0002045)2.15645567
89Lower limb muscle weakness (HP:0007340)2.14824433
90Anxiety (HP:0000739)2.14688891
91Progressive inability to walk (HP:0002505)2.14061815
92Abnormal hair whorl (HP:0010721)2.12517158
93Genetic anticipation (HP:0003743)2.12131321
94Spontaneous hematomas (HP:0007420)2.11241234
95Impaired vibration sensation in the lower limbs (HP:0002166)2.10739604
96Congenital primary aphakia (HP:0007707)2.10441436
97Basal ganglia calcification (HP:0002135)2.09962413
98Medial flaring of the eyebrow (HP:0010747)2.08138332
99Abnormal respiratory motile cilium morphology (HP:0005938)2.07488232
100Abnormal respiratory epithelium morphology (HP:0012253)2.07488232
101Akinesia (HP:0002304)2.07162713
102Hyperglycemia (HP:0003074)2.06796948
103Urinary urgency (HP:0000012)2.06172471
104Epileptiform EEG discharges (HP:0011182)2.05581937
105Vaginal atresia (HP:0000148)2.05453803
106Genital tract atresia (HP:0001827)2.05257250
107Specific learning disability (HP:0001328)2.05233238
108Orchitis (HP:0100796)2.04978556
109Agitation (HP:0000713)2.04436737
110Amyloidosis (HP:0011034)2.04042796
111Gaze-evoked nystagmus (HP:0000640)2.03681451
112Spastic gait (HP:0002064)2.02447717
113Recurrent cutaneous fungal infections (HP:0011370)2.02210797
114Chronic mucocutaneous candidiasis (HP:0002728)2.02210797
115Narrow nasal bridge (HP:0000446)2.02119548
116Parakeratosis (HP:0001036)2.01809808
117Stereotypic behavior (HP:0000733)2.00796355
118Nuclear cataract (HP:0100018)2.00478759
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.99710804
120Optic neuritis (HP:0100653)1.99022833
121Retrobulbar optic neuritis (HP:0100654)1.99022833
122Hypoglycemic coma (HP:0001325)1.97359678
123Synostosis involving the elbow (HP:0003938)1.97063144
124Humeroradial synostosis (HP:0003041)1.97063144
125Pancreatic cysts (HP:0001737)1.96566187
126EEG with generalized epileptiform discharges (HP:0011198)1.96078642
127Neuronal loss in central nervous system (HP:0002529)1.95056028
128Mediastinal lymphadenopathy (HP:0100721)1.94484364
129Blue irides (HP:0000635)1.94439984
130Recurrent fungal infections (HP:0002841)1.93878929
131Disinhibition (HP:0000734)1.93777900
132Scanning speech (HP:0002168)1.92389911
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89495932
134Fetal akinesia sequence (HP:0001989)1.88163940
135Chronic obstructive pulmonary disease (HP:0006510)1.87917392
136Obstructive lung disease (HP:0006536)1.87917392
137Poor eye contact (HP:0000817)1.87542724
138Recurrent sinusitis (HP:0011108)1.86676633
139Abnormal ciliary motility (HP:0012262)1.86224689
140Torticollis (HP:0000473)1.86204880
141Thickened helices (HP:0000391)1.85900416
142Widely spaced teeth (HP:0000687)1.84173326
143Abnormality of salivation (HP:0100755)1.83442697
144Clumsiness (HP:0002312)1.83333449
145Hypsarrhythmia (HP:0002521)1.82181198
146Nasal polyposis (HP:0100582)1.80696770
147Protruding tongue (HP:0010808)1.80250263
148Abnormality of endocrine pancreas physiology (HP:0012093)1.77760822
149Abnormality of the pancreatic islet cells (HP:0006476)1.77760822
150Postural tremor (HP:0002174)1.77721926
151Choroideremia (HP:0001139)1.77171273
152Nephronophthisis (HP:0000090)1.76943440
153Increased neuronal autofluorescent lipopigment (HP:0002074)1.75932895
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.75732460
155Absent/shortened dynein arms (HP:0200106)1.75732460
156Amyotrophic lateral sclerosis (HP:0007354)1.75704951
157Apathy (HP:0000741)1.75608317
158Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75470023
159Mitral stenosis (HP:0001718)1.74832203
160Large for gestational age (HP:0001520)1.74427310
161Gastrointestinal infarctions (HP:0005244)1.73877940
162Sensory axonal neuropathy (HP:0003390)1.73114112
163Postural instability (HP:0002172)1.71660425
164Cutaneous finger syndactyly (HP:0010554)1.71285174
165Generalized myoclonic seizures (HP:0002123)1.71102253
166Global brain atrophy (HP:0002283)1.70391791
167Molar tooth sign on MRI (HP:0002419)1.70040109
168Abnormality of midbrain morphology (HP:0002418)1.70040109
169Hypochromic microcytic anemia (HP:0004840)1.69764321
170Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69569326
171Increased cerebral lipofuscin (HP:0011813)1.68715306
172Abnormality of the nasal mucosa (HP:0000433)1.67050207
173Asplenia (HP:0001746)1.62923471
174Chronic sinusitis (HP:0011109)1.61863812
175Arterial thrombosis (HP:0004420)1.61395229
176Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.61370393
177Asymmetric septal hypertrophy (HP:0001670)1.60812864
178Aplasia/Hypoplasia of the spleen (HP:0010451)1.60479143
179Vasculitis (HP:0002633)1.59935131
180Abnormal respiratory motile cilium physiology (HP:0012261)1.59660256
181Ketosis (HP:0001946)1.57584760
182Sex reversal (HP:0012245)1.57133978
183Abnormal sex determination (HP:0012244)1.57133978
184Sensorimotor neuropathy (HP:0007141)1.56734232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.52570824
2FRK4.38519323
3EPHA43.89847552
4MARK13.72634460
5ACVR1B3.07505902
6NTRK32.75836110
7MAP2K72.36382170
8MAP3K42.35486272
9TNK22.34240853
10MINK12.30266835
11IRAK12.06560510
12RIPK42.04468805
13MAP4K22.03365783
14TNIK1.97189582
15MAPK131.94212468
16MAP3K91.92812393
17IRAK41.90978384
18PLK21.82382102
19BLK1.78641260
20NTRK21.74789816
21DAPK21.71528455
22OXSR11.69636099
23PHKG11.61187612
24PHKG21.61187612
25PINK11.59372396
26MST41.55434411
27TYK21.52601620
28MAP3K121.50782061
29MAP2K41.45732619
30PAK61.43418229
31MAP4K11.43143924
32MOS1.42595806
33NTRK11.42051258
34STK391.40864249
35SGK2231.40781905
36SGK4941.40781905
37TEC1.40041738
38ADRBK21.38160436
39ERBB31.35539105
40JAK11.30492712
41MAP3K141.30274894
42ARAF1.29156917
43STK241.29149161
44FGFR31.29089760
45GRK51.26932558
46CSK1.26776033
47FGR1.26109463
48JAK31.24588151
49TGFBR21.24397199
50CDK51.23111318
51TRPM71.20533710
52PKN11.20111462
53SYK1.19472550
54HCK1.18072089
55CAMK2A1.18050110
56PRPF4B1.17751559
57DYRK21.14905956
58FES1.14774879
59IKBKE1.11530320
60PRKCE1.08347187
61NLK1.08261355
62CAMK2B1.07317458
63IRAK21.05473858
64MAP3K21.02901610
65LYN1.02796490
66CSF1R1.01975340
67UHMK11.01625851
68BTK1.01210289
69MATK1.00493928
70SGK21.00219432
71MAPKAPK50.99801997
72TBK10.99088197
73TAOK30.98219756
74MAP2K30.96648978
75ZAP700.96404687
76GRK10.96291464
77STK30.96268815
78KSR20.96001512
79PRKCG0.95295693
80PRKCH0.94304948
81SIK20.94129035
82PRKD20.93974356
83CDK190.93656012
84BMPR20.93653950
85CAMKK20.93521769
86BCR0.92401966
87IKBKB0.90883750
88KSR10.88902646
89CAMK2D0.86101819
90PAK30.84864202
91CSNK1G20.83984044
92KIT0.82804026
93NEK90.82732282
94CDK140.81577833
95JAK20.81114565
96STK160.80882387
97PRKCQ0.80873314
98PNCK0.79804457
99ITK0.78544553
100RET0.78241793
101GRK60.78107982
102DYRK1A0.76581048
103FER0.75622175
104CAMKK10.75473760
105HIPK20.75219449
106LIMK10.74875069
107MARK30.74637128
108PTK2B0.73801256
109MAPK70.73495464
110LCK0.73388639
111CDK180.72811344
112DDR20.71869249
113CDK150.71687672
114TXK0.71650744
115MAP3K10.70900735
116BRD40.70293762
117ROCK20.70276792
118SGK10.68129858
119NUAK10.67865877
120MAP3K60.67569995
121PIK3CA0.66972466
122NEK60.66529172
123BMPR1B0.65925149
124MUSK0.65732518
125WNK30.65390192
126DAPK10.63907594
127FGFR20.63116980
128CAMK1G0.62310215
129TYRO30.61707916
130SGK30.61687990
131RAF10.61516940
132ADRBK10.61247223
133CAMK2G0.61109274
134RPS6KA40.60983826
135PIK3CG0.60901293
136EPHA30.60868486
137MAP3K130.59025568
138CSNK1G30.58806515
139PDPK10.57944734
140CDK11A0.57445207
141MARK20.57332391
142STK110.56464210
143DYRK30.55260017
144YES10.55037105
145PRKCZ0.54359198
146GRK70.53071221
147EPHB10.52578573
148RPS6KA20.51645642
149EGFR0.50652590
150FYN0.50390042
151AKT30.47293251
152ABL10.45268087
153TAOK10.45103322
154MAP2K10.43153231
155ROCK10.43032000
156TIE10.42897245
157PRKG10.42336771
158CSNK1A1L0.41712540
159INSRR0.41419470
160MAP2K60.41287601
161PDK10.41251816
162MAPK120.40520729
163ERN10.39847696
164WNK40.39551876
165WNK10.36242040

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.15047296
2Synaptic vesicle cycle_Homo sapiens_hsa047212.71153679
3Other glycan degradation_Homo sapiens_hsa005112.67319569
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.57078744
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42473687
6GABAergic synapse_Homo sapiens_hsa047272.40609823
7Circadian entrainment_Homo sapiens_hsa047132.39822850
8Morphine addiction_Homo sapiens_hsa050322.29161775
9Lysosome_Homo sapiens_hsa041422.23525765
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.23234794
11Glutamatergic synapse_Homo sapiens_hsa047242.19089330
12Olfactory transduction_Homo sapiens_hsa047402.16224418
13Long-term potentiation_Homo sapiens_hsa047201.91902734
14Dopaminergic synapse_Homo sapiens_hsa047281.91811275
15Serotonergic synapse_Homo sapiens_hsa047261.90064045
16Osteoclast differentiation_Homo sapiens_hsa043801.88885204
17Collecting duct acid secretion_Homo sapiens_hsa049661.86009585
18Amphetamine addiction_Homo sapiens_hsa050311.80700762
19Cholinergic synapse_Homo sapiens_hsa047251.80186055
20Renin secretion_Homo sapiens_hsa049241.72315766
21Leishmaniasis_Homo sapiens_hsa051401.70813363
22Taste transduction_Homo sapiens_hsa047421.70530280
23Long-term depression_Homo sapiens_hsa047301.67410817
24Salivary secretion_Homo sapiens_hsa049701.66669638
25Cocaine addiction_Homo sapiens_hsa050301.59019136
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58792525
27Insulin secretion_Homo sapiens_hsa049111.56942841
28Axon guidance_Homo sapiens_hsa043601.55468476
29Tuberculosis_Homo sapiens_hsa051521.50275787
30Staphylococcus aureus infection_Homo sapiens_hsa051501.47475033
31Gastric acid secretion_Homo sapiens_hsa049711.47270984
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40015740
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33707300
34B cell receptor signaling pathway_Homo sapiens_hsa046621.33514478
35Regulation of autophagy_Homo sapiens_hsa041401.28789677
36Oxytocin signaling pathway_Homo sapiens_hsa049211.27422302
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27208983
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26630665
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25559390
40Calcium signaling pathway_Homo sapiens_hsa040201.24750414
41Vibrio cholerae infection_Homo sapiens_hsa051101.22402043
42Legionellosis_Homo sapiens_hsa051341.20064327
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19035680
44Allograft rejection_Homo sapiens_hsa053301.17745580
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17278508
46Graft-versus-host disease_Homo sapiens_hsa053321.16947380
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15418801
48Gap junction_Homo sapiens_hsa045401.14914344
49GnRH signaling pathway_Homo sapiens_hsa049121.12611788
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12206300
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10658539
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09614373
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07279604
54Malaria_Homo sapiens_hsa051441.05530966
55Type II diabetes mellitus_Homo sapiens_hsa049301.00763559
56cAMP signaling pathway_Homo sapiens_hsa040241.00043059
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98349719
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98038825
59Estrogen signaling pathway_Homo sapiens_hsa049150.96772882
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96421530
61Autoimmune thyroid disease_Homo sapiens_hsa053200.95493826
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95368578
63Butanoate metabolism_Homo sapiens_hsa006500.94964084
64Dorso-ventral axis formation_Homo sapiens_hsa043200.94132042
65ErbB signaling pathway_Homo sapiens_hsa040120.93277869
66Melanogenesis_Homo sapiens_hsa049160.92738502
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91298144
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89414354
69Antigen processing and presentation_Homo sapiens_hsa046120.86942746
70Rheumatoid arthritis_Homo sapiens_hsa053230.86901439
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.86734296
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86542478
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85848168
74African trypanosomiasis_Homo sapiens_hsa051430.84664828
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83736134
76Hematopoietic cell lineage_Homo sapiens_hsa046400.82999993
77Measles_Homo sapiens_hsa051620.81870330
78Phagosome_Homo sapiens_hsa041450.81281308
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79799359
80Phototransduction_Homo sapiens_hsa047440.79277057
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.78101958
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.77974701
83Cardiac muscle contraction_Homo sapiens_hsa042600.77959133
84Alzheimers disease_Homo sapiens_hsa050100.77220267
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.77003715
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.76985946
87Glioma_Homo sapiens_hsa052140.76013763
88Asthma_Homo sapiens_hsa053100.74784826
89Prolactin signaling pathway_Homo sapiens_hsa049170.74444558
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74223469
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72574921
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72405279
93Thyroid hormone synthesis_Homo sapiens_hsa049180.71826142
94Pertussis_Homo sapiens_hsa051330.70759157
95Toxoplasmosis_Homo sapiens_hsa051450.70195381
96Protein export_Homo sapiens_hsa030600.69892868
97Oxidative phosphorylation_Homo sapiens_hsa001900.69892574
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68854139
99ABC transporters_Homo sapiens_hsa020100.68604964
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.68231277
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.68202580
102Steroid biosynthesis_Homo sapiens_hsa001000.67941192
103MAPK signaling pathway_Homo sapiens_hsa040100.67432123
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67118202
105Primary immunodeficiency_Homo sapiens_hsa053400.66961528
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66774482
107TNF signaling pathway_Homo sapiens_hsa046680.66740453
108T cell receptor signaling pathway_Homo sapiens_hsa046600.66307163
109Pancreatic secretion_Homo sapiens_hsa049720.65302797
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64527817
111Ras signaling pathway_Homo sapiens_hsa040140.64119139
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63330668
113Ether lipid metabolism_Homo sapiens_hsa005650.63075287
114Dilated cardiomyopathy_Homo sapiens_hsa054140.60756187
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.60271712
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58523612
117Renal cell carcinoma_Homo sapiens_hsa052110.58016676
118FoxO signaling pathway_Homo sapiens_hsa040680.56695568
119Choline metabolism in cancer_Homo sapiens_hsa052310.56508263
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56461401
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55916630
122Ovarian steroidogenesis_Homo sapiens_hsa049130.55465166
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54801894
124Hepatitis C_Homo sapiens_hsa051600.54582388
125Rap1 signaling pathway_Homo sapiens_hsa040150.54042172
126Salmonella infection_Homo sapiens_hsa051320.53762449
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53246989
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52195805
129Prion diseases_Homo sapiens_hsa050200.51408838
130Endometrial cancer_Homo sapiens_hsa052130.51338697
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51286333
132Type I diabetes mellitus_Homo sapiens_hsa049400.49667091
133Influenza A_Homo sapiens_hsa051640.49182425
134Peroxisome_Homo sapiens_hsa041460.49128392
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48707730
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47705509
137Sphingolipid metabolism_Homo sapiens_hsa006000.46838721
138mTOR signaling pathway_Homo sapiens_hsa041500.46576176
139Chemokine signaling pathway_Homo sapiens_hsa040620.46235736
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45936085
141Shigellosis_Homo sapiens_hsa051310.45783929
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45186433
143Alcoholism_Homo sapiens_hsa050340.43886032
144Inositol phosphate metabolism_Homo sapiens_hsa005620.42715430
145Herpes simplex infection_Homo sapiens_hsa051680.42338601
146Endocytosis_Homo sapiens_hsa041440.41693883
147Arachidonic acid metabolism_Homo sapiens_hsa005900.41590343
148VEGF signaling pathway_Homo sapiens_hsa043700.41054235
149Parkinsons disease_Homo sapiens_hsa050120.39570694
150Acute myeloid leukemia_Homo sapiens_hsa052210.38779498
151Melanoma_Homo sapiens_hsa052180.38664272
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38503883
153Wnt signaling pathway_Homo sapiens_hsa043100.37903617
154Fatty acid elongation_Homo sapiens_hsa000620.34032302
155Platelet activation_Homo sapiens_hsa046110.33454353
156Mineral absorption_Homo sapiens_hsa049780.33181374
157Colorectal cancer_Homo sapiens_hsa052100.32053254

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