API5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.45922497
2establishment of integrated proviral latency (GO:0075713)5.06985776
3nuclear pore organization (GO:0006999)4.76646678
4protein localization to kinetochore (GO:0034501)4.70427279
5nuclear pore complex assembly (GO:0051292)4.60468442
6folic acid-containing compound biosynthetic process (GO:0009396)4.44650015
7DNA strand elongation involved in DNA replication (GO:0006271)4.39258999
8mitotic nuclear envelope disassembly (GO:0007077)4.38692349
9DNA replication initiation (GO:0006270)4.28015801
10non-recombinational repair (GO:0000726)4.21868454
11double-strand break repair via nonhomologous end joining (GO:0006303)4.21868454
12IMP biosynthetic process (GO:0006188)4.17072921
13DNA strand elongation (GO:0022616)4.17052924
14membrane disassembly (GO:0030397)4.12518557
15nuclear envelope disassembly (GO:0051081)4.12518557
16protein localization to chromosome, centromeric region (GO:0071459)3.97561781
17IMP metabolic process (GO:0046040)3.95482320
18establishment of viral latency (GO:0019043)3.91090271
19DNA ligation (GO:0006266)3.90398927
20DNA replication-dependent nucleosome organization (GO:0034723)3.88935665
21DNA replication-dependent nucleosome assembly (GO:0006335)3.88935665
22nucleobase biosynthetic process (GO:0046112)3.88079477
23mitotic chromosome condensation (GO:0007076)3.87429397
24telomere maintenance via semi-conservative replication (GO:0032201)3.77902338
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77808149
26mitotic metaphase plate congression (GO:0007080)3.70780898
27DNA duplex unwinding (GO:0032508)3.67432620
28mitotic spindle checkpoint (GO:0071174)3.67098438
29DNA geometric change (GO:0032392)3.64484258
30formation of translation preinitiation complex (GO:0001731)3.61933992
31regulation of spindle organization (GO:0090224)3.60995897
32regulation of double-strand break repair via homologous recombination (GO:0010569)3.59727473
33histone-serine phosphorylation (GO:0035404)3.58887670
34purine nucleobase biosynthetic process (GO:0009113)3.54481288
35regulation of centriole replication (GO:0046599)3.52202950
36mitotic sister chromatid cohesion (GO:0007064)3.51428796
37mitotic recombination (GO:0006312)3.50493000
38DNA replication checkpoint (GO:0000076)3.49363948
39protein complex localization (GO:0031503)3.48483800
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48326110
41telomere maintenance via recombination (GO:0000722)3.48256601
42negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.47804998
43sister chromatid segregation (GO:0000819)3.46011340
44attachment of spindle microtubules to kinetochore (GO:0008608)3.45762817
45dosage compensation (GO:0007549)3.45265923
46pore complex assembly (GO:0046931)3.42977343
47translesion synthesis (GO:0019985)3.42956591
48regulation of histone H3-K9 methylation (GO:0051570)3.42458844
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35892988
50metaphase plate congression (GO:0051310)3.31876078
51positive regulation of chromosome segregation (GO:0051984)3.30948712
52regulation of sister chromatid segregation (GO:0033045)3.30937042
53regulation of mitotic sister chromatid separation (GO:0010965)3.30937042
54regulation of mitotic sister chromatid segregation (GO:0033047)3.30937042
55nuclear envelope organization (GO:0006998)3.30874750
56mitotic sister chromatid segregation (GO:0000070)3.30531297
57negative regulation of histone methylation (GO:0031061)3.28214975
58ribosome assembly (GO:0042255)3.23546464
59regulation of translational termination (GO:0006449)3.20728804
60DNA replication-independent nucleosome assembly (GO:0006336)3.19500486
61DNA replication-independent nucleosome organization (GO:0034724)3.19500486
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19490225
63chromatin remodeling at centromere (GO:0031055)3.18848224
64CENP-A containing nucleosome assembly (GO:0034080)3.18446327
65tRNA aminoacylation for protein translation (GO:0006418)3.16711012
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14586215
67negative regulation of RNA splicing (GO:0033119)3.13516558
68DNA double-strand break processing (GO:0000729)3.11893046
69cellular protein complex localization (GO:0034629)3.10871760
70postreplication repair (GO:0006301)3.09016208
71amino acid activation (GO:0043038)3.08528126
72tRNA aminoacylation (GO:0043039)3.08528126
73heterochromatin organization (GO:0070828)3.08462929
74establishment of chromosome localization (GO:0051303)3.08159678
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07530157
763-UTR-mediated mRNA stabilization (GO:0070935)3.07286934
77regulation of translational fidelity (GO:0006450)3.06282281
78regulation of mitotic spindle organization (GO:0060236)3.05694089
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05192339
80kinetochore organization (GO:0051383)3.04330205
81proteasome assembly (GO:0043248)3.04140917
82RNA-dependent DNA replication (GO:0006278)3.02359596
83telomere maintenance via telomere lengthening (GO:0010833)3.02095968
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.01041615
85negative regulation of DNA recombination (GO:0045910)3.00819119
86negative regulation of mRNA metabolic process (GO:1903312)2.99267868
87regulation of sister chromatid cohesion (GO:0007063)2.98639896
88response to X-ray (GO:0010165)2.97091760
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.96042682
90chromatin assembly or disassembly (GO:0006333)2.94847913
91regulation of helicase activity (GO:0051095)2.94080651
92DNA conformation change (GO:0071103)2.93454136
93protein localization to chromosome (GO:0034502)2.92971095
94telomere organization (GO:0032200)2.92544260
95regulation of chromosome segregation (GO:0051983)2.91129665
96somatic hypermutation of immunoglobulin genes (GO:0016446)2.89956597
97somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89956597
98pre-miRNA processing (GO:0031054)2.89394742
99DNA topological change (GO:0006265)2.84910323
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84261408
101positive regulation of mitotic sister chromatid separation (GO:1901970)2.84182382
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84182382
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84182382
104negative regulation of mRNA processing (GO:0050686)2.83017820
105Golgi transport vesicle coating (GO:0048200)2.81793740
106COPI coating of Golgi vesicle (GO:0048205)2.81793740
107spindle assembly checkpoint (GO:0071173)2.80937719
108RNA stabilization (GO:0043489)2.78007230
109mRNA stabilization (GO:0048255)2.78007230
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76466691
111glucocorticoid receptor signaling pathway (GO:0042921)2.76214996
112regulation of centrosome cycle (GO:0046605)2.76211001
113spindle checkpoint (GO:0031577)2.76179324
114chromatin assembly (GO:0031497)2.75810532
115negative regulation of chromosome segregation (GO:0051985)2.75801509
116mitotic spindle assembly checkpoint (GO:0007094)2.75443401
117mRNA transport (GO:0051028)2.75262437
118ribosomal small subunit assembly (GO:0000028)2.75082682
119histone exchange (GO:0043486)2.74876524
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74620811
121negative regulation of sister chromatid segregation (GO:0033046)2.74620811
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.74620811
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74620811
124ATP-dependent chromatin remodeling (GO:0043044)2.72204647
125mRNA splicing, via spliceosome (GO:0000398)2.71688259
126RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71688259
127telomere maintenance (GO:0000723)2.70971664
128RNA splicing, via transesterification reactions (GO:0000375)2.69872704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.76596314
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.46395960
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68347862
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.60966202
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.58569996
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38239504
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98595818
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47463649
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40549172
10AR_21909140_ChIP-Seq_LNCAP_Human2.39804033
11MYC_22102868_ChIP-Seq_BL_Human2.25782130
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21377577
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13041707
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.10238248
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09672230
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05464314
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.05093848
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00728220
19* XRN2_22483619_ChIP-Seq_HELA_Human1.97924596
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91779990
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.89187241
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88285622
23* ETS1_20019798_ChIP-Seq_JURKAT_Human1.83057138
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82050900
25VDR_23849224_ChIP-Seq_CD4+_Human1.78602197
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75644382
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73650524
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72089596
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69198709
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68912964
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67535089
32CIITA_25753668_ChIP-Seq_RAJI_Human1.66217397
33* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65055830
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63926565
35FOXP3_21729870_ChIP-Seq_TREG_Human1.63301595
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60881767
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60330535
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59638355
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56142811
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55517547
41ELK1_19687146_ChIP-ChIP_HELA_Human1.53847961
42* DCP1A_22483619_ChIP-Seq_HELA_Human1.50366551
43GABP_19822575_ChIP-Seq_HepG2_Human1.48194961
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46803515
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46622771
46KDM5A_27292631_Chip-Seq_BREAST_Human1.42139014
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41558270
48TTF2_22483619_ChIP-Seq_HELA_Human1.39385785
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37944792
50TFEB_21752829_ChIP-Seq_HELA_Human1.37907556
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37903214
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36921787
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36683591
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35433557
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35208444
56VDR_21846776_ChIP-Seq_THP-1_Human1.34914640
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34006540
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.30746679
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30036172
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29551674
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29002735
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28294482
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25468744
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23629257
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22476734
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22338051
67* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18035284
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17131872
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.16891575
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15982632
71SOX17_20123909_ChIP-Seq_XEN_Mouse1.15738934
72SPI1_23547873_ChIP-Seq_NB4_Human1.14618016
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.12174807
74* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11832225
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11692953
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11039871
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09415172
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.08299943
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05862579
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04908532
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04742169
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04614417
83MYB_26560356_Chip-Seq_TH2_Human1.02955572
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01628418
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00673895
86* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99134637
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98509664
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98268784
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97991893
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97638978
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96553832
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96330957
93FUS_26573619_Chip-Seq_HEK293_Human0.96181583
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.95684945
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95474712
96MYC_18940864_ChIP-ChIP_HL60_Human0.95264578
97MYB_26560356_Chip-Seq_TH1_Human0.95137478
98EWS_26573619_Chip-Seq_HEK293_Human0.94662531
99MAF_26560356_Chip-Seq_TH1_Human0.93807131
100CLOCK_20551151_ChIP-Seq_293T_Human0.93457660
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92854704
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92268487
103BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92188854
104* UTX_26944678_Chip-Seq_JUKART_Human0.91481491
105* CHD1_26751641_Chip-Seq_LNCaP_Human0.91159955
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.90262217
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90227071
108TCF7_22412390_ChIP-Seq_EML_Mouse0.89609631
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.89373858
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88333028
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88121389
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86721206
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86369260
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85721911
115* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85280536
116* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84841961
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84777543
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83270415
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82340485
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81273159
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.81209940
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.81017240
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79457009
124SCL_19346495_ChIP-Seq_HPC-7_Human0.79285239
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79225101
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76373831
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75489423
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74616359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.04443140
2MP0010094_abnormal_chromosome_stability3.77975829
3MP0004957_abnormal_blastocyst_morpholog3.52099966
4MP0003111_abnormal_nucleus_morphology3.46677336
5MP0010352_gastrointestinal_tract_polyps3.33760993
6MP0003077_abnormal_cell_cycle3.26074707
7MP0008057_abnormal_DNA_replication3.19286604
8MP0002396_abnormal_hematopoietic_system2.50749707
9MP0008007_abnormal_cellular_replicative2.49502232
10MP0009697_abnormal_copulation2.46296459
11MP0010307_abnormal_tumor_latency2.39924946
12MP0001730_embryonic_growth_arrest2.21821031
13MP0000350_abnormal_cell_proliferation2.21460602
14MP0003941_abnormal_skin_development2.21095335
15MP0006054_spinal_hemorrhage2.19583425
16MP0008058_abnormal_DNA_repair2.18485566
17MP0004808_abnormal_hematopoietic_stem2.16431022
18MP0005076_abnormal_cell_differentiation2.03352523
19MP0000490_abnormal_crypts_of1.91365111
20MP0003123_paternal_imprinting1.88118727
21MP0003718_maternal_effect1.86885387
22MP0008932_abnormal_embryonic_tissue1.82335560
23MP0003705_abnormal_hypodermis_morpholog1.68013705
24MP0001697_abnormal_embryo_size1.65266307
25MP0001672_abnormal_embryogenesis/_devel1.62460348
26MP0005380_embryogenesis_phenotype1.62460348
27MP0003300_gastrointestinal_ulcer1.58682540
28MP0003984_embryonic_growth_retardation1.54328557
29MP0004197_abnormal_fetal_growth/weight/1.54104981
30MP0002086_abnormal_extraembryonic_tissu1.53424548
31MP0002080_prenatal_lethality1.52899565
32MP0002088_abnormal_embryonic_growth/wei1.52750243
33MP0002877_abnormal_melanocyte_morpholog1.52399417
34MP0005397_hematopoietic_system_phenotyp1.46517716
35MP0001545_abnormal_hematopoietic_system1.46517716
36MP0002084_abnormal_developmental_patter1.41215888
37MP0002019_abnormal_tumor_incidence1.40954228
38MP0002085_abnormal_embryonic_tissue1.38533326
39MP0009278_abnormal_bone_marrow1.36818263
40MP0002398_abnormal_bone_marrow1.31624438
41MP0003763_abnormal_thymus_physiology1.29455430
42MP0000313_abnormal_cell_death1.28648558
43MP0003937_abnormal_limbs/digits/tail_de1.25964075
44MP0009333_abnormal_splenocyte_physiolog1.25692088
45MP0000703_abnormal_thymus_morphology1.24735653
46MP0003567_abnormal_fetal_cardiomyocyte1.22160574
47MP0001661_extended_life_span1.21679276
48MP0003566_abnormal_cell_adhesion1.18850425
49MP0002166_altered_tumor_susceptibility1.17391584
50MP0002722_abnormal_immune_system1.17163530
51MP0010234_abnormal_vibrissa_follicle1.13741696
52MP0001915_intracranial_hemorrhage1.13177140
53MP0003890_abnormal_embryonic-extraembry1.12736915
54MP0000689_abnormal_spleen_morphology1.10818880
55MP0002796_impaired_skin_barrier1.10322371
56MP0000465_gastrointestinal_hemorrhage1.10167625
57MP0006035_abnormal_mitochondrial_morpho1.07956878
58MP0003786_premature_aging1.07412384
59MP0009053_abnormal_anal_canal1.06107578
60MP0001293_anophthalmia1.05460843
61MP0005023_abnormal_wound_healing1.03687897
62MP0010678_abnormal_skin_adnexa1.03214438
63MP0001346_abnormal_lacrimal_gland1.02952349
64MP0000858_altered_metastatic_potential1.02887455
65MP0003436_decreased_susceptibility_to1.01481538
66MP0003303_peritoneal_inflammation1.01420440
67MP0002429_abnormal_blood_cell1.00617765
68MP0010030_abnormal_orbit_morphology0.97664166
69MP0002006_tumorigenesis0.96888996
70MP0000579_abnormal_nail_morphology0.96070447
71MP0003121_genomic_imprinting0.95998316
72MP0003315_abnormal_perineum_morphology0.95862510
73MP0009672_abnormal_birth_weight0.95640883
74MP0003943_abnormal_hepatobiliary_system0.95106180
75MP0001849_ear_inflammation0.94282066
76MP0000371_diluted_coat_color0.94230348
77MP0000537_abnormal_urethra_morphology0.93983818
78MP0008877_abnormal_DNA_methylation0.93707811
79MP0000716_abnormal_immune_system0.91895779
80MP0002233_abnormal_nose_morphology0.91668164
81MP0003806_abnormal_nucleotide_metabolis0.91319815
82MP0004185_abnormal_adipocyte_glucose0.91025183
83MP0002009_preneoplasia0.88994040
84MP0005623_abnormal_meninges_morphology0.88717768
85MP0000733_abnormal_muscle_development0.88606802
86MP0001800_abnormal_humoral_immune0.88340912
87MP0005499_abnormal_olfactory_system0.87652142
88MP0005394_taste/olfaction_phenotype0.87652142
89MP0004264_abnormal_extraembryonic_tissu0.87627335
90MP0010155_abnormal_intestine_physiology0.86745412
91MP0005501_abnormal_skin_physiology0.86680649
92MP0002697_abnormal_eye_size0.86248237
93MP0000477_abnormal_intestine_morphology0.85439745
94MP0005621_abnormal_cell_physiology0.85245046
95MP0000377_abnormal_hair_follicle0.84530894
96MP0001216_abnormal_epidermal_layer0.84038218
97MP0002452_abnormal_antigen_presenting0.83737569
98MP0002420_abnormal_adaptive_immunity0.83556247
99MP0001819_abnormal_immune_cell0.81896815
100MP0001835_abnormal_antigen_presentation0.81218730
101MP0001727_abnormal_embryo_implantation0.81013943
102MP0005384_cellular_phenotype0.80510322
103MP0001188_hyperpigmentation0.80431093
104MP0000647_abnormal_sebaceous_gland0.79788356
105MP0004947_skin_inflammation0.79761530
106MP0001177_atelectasis0.79456570
107MP0001286_abnormal_eye_development0.78589666
108MP0009703_decreased_birth_body0.77692555
109MP0005187_abnormal_penis_morphology0.77199608
110MP0002111_abnormal_tail_morphology0.77061346
111MP0001299_abnormal_eye_distance/0.76232584
112MP0003448_altered_tumor_morphology0.75263189
113MP0003385_abnormal_body_wall0.75178149
114MP0003119_abnormal_digestive_system0.74751586
115MP0008789_abnormal_olfactory_epithelium0.74229809
116MP0000432_abnormal_head_morphology0.74099325
117MP0002092_abnormal_eye_morphology0.73697080
118MP0002405_respiratory_system_inflammati0.73428829
119MP0000627_abnormal_mammary_gland0.72663717
120MP0001529_abnormal_vocalization0.72658016
121MP0001853_heart_inflammation0.71125595
122MP0004233_abnormal_muscle_weight0.70717693
123MP0001929_abnormal_gametogenesis0.70264295
124MP0000428_abnormal_craniofacial_morphol0.70127672
125MP0001873_stomach_inflammation0.70022147
126MP0004782_abnormal_surfactant_physiolog0.69988325
127MP0000358_abnormal_cell_content/0.69339857
128MP0002102_abnormal_ear_morphology0.69032968
129MP0002925_abnormal_cardiovascular_devel0.68810328
130MP0002075_abnormal_coat/hair_pigmentati0.68660963
131MP0001881_abnormal_mammary_gland0.68504758
132MP0005464_abnormal_platelet_physiology0.68144424
133MP0002723_abnormal_immune_serum0.66701033
134MP0005671_abnormal_response_to0.66468231
135MP0003221_abnormal_cardiomyocyte_apopto0.66442377
136MP0003935_abnormal_craniofacial_develop0.66121869
137MP0000685_abnormal_immune_system0.65991993
138MP0001243_abnormal_dermal_layer0.64587308
139MP0001145_abnormal_male_reproductive0.63986774
140MP0002210_abnormal_sex_determination0.63700454
141MP0000569_abnormal_digit_pigmentation0.63544321
142MP0004272_abnormal_basement_membrane0.63094278
143MP0002177_abnormal_outer_ear0.62693620
144MP0005395_other_phenotype0.62461220
145MP0003861_abnormal_nervous_system0.60327928

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.23584621
2Colon cancer (HP:0003003)3.71384473
3Degeneration of anterior horn cells (HP:0002398)3.68824496
4Abnormality of the anterior horn cell (HP:0006802)3.68824496
5Cortical dysplasia (HP:0002539)3.56057612
6Medulloblastoma (HP:0002885)3.52777379
7Birth length less than 3rd percentile (HP:0003561)3.42246851
8Ependymoma (HP:0002888)3.29569049
9Agnosia (HP:0010524)3.20770040
10Nephroblastoma (Wilms tumor) (HP:0002667)3.08616747
11Embryonal renal neoplasm (HP:0011794)3.05450542
12Selective tooth agenesis (HP:0001592)3.01303459
13Short 4th metacarpal (HP:0010044)2.94138203
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94138203
15Multiple enchondromatosis (HP:0005701)2.83226057
16Rhabdomyosarcoma (HP:0002859)2.77841883
17Abnormality of the preputium (HP:0100587)2.76820218
18Abnormal lung lobation (HP:0002101)2.75950108
19Basal cell carcinoma (HP:0002671)2.75463673
20Abnormality of glycolysis (HP:0004366)2.75165195
21Amaurosis fugax (HP:0100576)2.62188596
22Biliary tract neoplasm (HP:0100574)2.53219831
23Aplastic anemia (HP:0001915)2.52630172
24Increased serum pyruvate (HP:0003542)2.52201470
25Proximal placement of thumb (HP:0009623)2.52039438
26Atrophy/Degeneration involving motor neurons (HP:0007373)2.51649193
27Deviation of the thumb (HP:0009603)2.51370289
28Microvesicular hepatic steatosis (HP:0001414)2.49905632
29Thrombocytosis (HP:0001894)2.49619661
30Ankle contracture (HP:0006466)2.48379293
31Progressive external ophthalmoplegia (HP:0000590)2.45911994
32Myelodysplasia (HP:0002863)2.44538956
33Abnormality of the duodenum (HP:0002246)2.43963196
34Abnormality of chromosome stability (HP:0003220)2.43838682
3511 pairs of ribs (HP:0000878)2.39447861
36Neoplasm of the pancreas (HP:0002894)2.34200541
37Increased nuchal translucency (HP:0010880)2.30092609
38Neoplasm of the oral cavity (HP:0100649)2.29798498
39Gonadotropin excess (HP:0000837)2.28896856
40Astrocytoma (HP:0009592)2.27866274
41Abnormality of the astrocytes (HP:0100707)2.27866274
42Volvulus (HP:0002580)2.25777577
43Breast hypoplasia (HP:0003187)2.24918171
44Abnormal umbilical cord blood vessels (HP:0011403)2.24468790
45Single umbilical artery (HP:0001195)2.24468790
46Abnormality of the fetal cardiovascular system (HP:0010948)2.24468790
47Reticulocytopenia (HP:0001896)2.24201859
48Hypoglycemic seizures (HP:0002173)2.20128792
49Reduced antithrombin III activity (HP:0001976)2.18724795
50Patellar aplasia (HP:0006443)2.15288052
51Insidious onset (HP:0003587)2.14576695
52Termporal pattern (HP:0011008)2.14576695
53Oral leukoplakia (HP:0002745)2.14429278
54Neoplasm of striated muscle (HP:0009728)2.12714890
55Glioma (HP:0009733)2.12575849
56Breast carcinoma (HP:0003002)2.12002766
57High pitched voice (HP:0001620)2.11480455
58Glossoptosis (HP:0000162)2.11437232
59Abnormality of the calcaneus (HP:0008364)2.10522373
60Increased density of long bones (HP:0006392)2.10127661
61Malignant gastrointestinal tract tumors (HP:0006749)2.09315046
62Gastrointestinal carcinoma (HP:0002672)2.09315046
63Missing ribs (HP:0000921)2.08130101
64Chromsome breakage (HP:0040012)2.07622032
65Abnormality of the umbilical cord (HP:0010881)2.05856259
66Back pain (HP:0003418)2.05269616
67Carpal bone hypoplasia (HP:0001498)2.05167007
68Aplasia/Hypoplasia of the patella (HP:0006498)2.04604039
69Choanal atresia (HP:0000453)2.03449727
70Ovarian neoplasm (HP:0100615)2.02027443
71Postnatal microcephaly (HP:0005484)2.02001651
72Prominent nose (HP:0000448)1.98739224
73Neoplasm of the rectum (HP:0100743)1.98634636
74Facial hemangioma (HP:0000329)1.98071497
75Freckling (HP:0001480)1.97001758
76Neoplasm of the colon (HP:0100273)1.96847139
77Hypoplastic labia majora (HP:0000059)1.96750252
78Embryonal neoplasm (HP:0002898)1.96371810
79Absent radius (HP:0003974)1.95831718
80Cutaneous melanoma (HP:0012056)1.95711969
81Abnormality of the distal phalanges of the toes (HP:0010182)1.95623121
82Abnormality of the 4th metacarpal (HP:0010012)1.95307293
83Pancreatic islet-cell hyperplasia (HP:0004510)1.95184892
84Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94575171
85Absent thumb (HP:0009777)1.93914686
86Hematochezia (HP:0002573)1.93418692
87Lymphoma (HP:0002665)1.92742289
88Abnormality of methionine metabolism (HP:0010901)1.92534052
89Neoplasm of the small intestine (HP:0100833)1.92043288
90Deep philtrum (HP:0002002)1.91809557
91Atresia of the external auditory canal (HP:0000413)1.91531079
92Absent forearm bone (HP:0003953)1.90350501
93Aplasia involving forearm bones (HP:0009822)1.90350501
94Central scotoma (HP:0000603)1.89982303
95Cafe-au-lait spot (HP:0000957)1.89509796
96Prominent metopic ridge (HP:0005487)1.89227973
97Overlapping toe (HP:0001845)1.89094701
98Abnormal biliary tract morphology (HP:0012440)1.88222134
99Papillary thyroid carcinoma (HP:0002895)1.87104459
100Premature graying of hair (HP:0002216)1.85179592
101Slender long bone (HP:0003100)1.85130007
102Neuroblastic tumors (HP:0004376)1.84503268
103Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.84503268
104Neuroblastoma (HP:0003006)1.84503268
105Primitive neuroectodermal tumor (HP:0030065)1.84503268
106Rough bone trabeculation (HP:0100670)1.84431409
107Recurrent viral infections (HP:0004429)1.82648717
108Hypoplastic female external genitalia (HP:0012815)1.82446017
109Cutis marmorata (HP:0000965)1.82407586
110Capillary hemangiomas (HP:0005306)1.82172449
111Ankyloglossia (HP:0010296)1.81594870
112Acute myeloid leukemia (HP:0004808)1.80578811
113IgM deficiency (HP:0002850)1.80563568
114Shoulder girdle muscle weakness (HP:0003547)1.80003130
115Abnormality of the metopic suture (HP:0005556)1.79873307
116Broad palm (HP:0001169)1.79748182
117Generalized hypotonia (HP:0001290)1.79538935
118Uterine neoplasm (HP:0010784)1.79166143
119High anterior hairline (HP:0009890)1.78749009
120Abnormality of the pancreatic islet cells (HP:0006476)1.78640311
121Abnormality of endocrine pancreas physiology (HP:0012093)1.78640311
122Curly hair (HP:0002212)1.78141875
123Meckel diverticulum (HP:0002245)1.78092144
124Small intestinal stenosis (HP:0012848)1.77947299
125Duodenal stenosis (HP:0100867)1.77947299
126Bone marrow hypocellularity (HP:0005528)1.76697718
127Hypoplastic pelvis (HP:0008839)1.76325335
128Abnormality of the carotid arteries (HP:0005344)1.76187319
129Hyperinsulinemic hypoglycemia (HP:0000825)1.75873762
130Pelvic girdle muscle weakness (HP:0003749)1.75223316
131Intestinal polyp (HP:0005266)1.74102645
132Microglossia (HP:0000171)1.73156525
133Angiofibromas (HP:0010615)1.73151385
134Adenoma sebaceum (HP:0009720)1.73151385
135Abnormality of T cells (HP:0002843)1.73061131
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72748073
137Long eyelashes (HP:0000527)1.72676034
138Symptomatic seizures (HP:0011145)1.72654267
139Aqueductal stenosis (HP:0002410)1.72138325
140Neoplasm of the adrenal gland (HP:0100631)1.71964974
141Abnormality of the peritoneum (HP:0002585)1.71727219
142Autoamputation (HP:0001218)1.71572385
143Abnormality of the ileum (HP:0001549)1.71148317
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.70715795
145Spastic diplegia (HP:0001264)1.69365339
146T lymphocytopenia (HP:0005403)1.68544600
147Intestinal polyposis (HP:0200008)1.67480149
148Sloping forehead (HP:0000340)1.66598564
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.65576040
150Abnormality of T cell physiology (HP:0011840)1.65255472
151Metaphyseal cupping (HP:0003021)1.64909798
152Trismus (HP:0000211)1.63643730
153Ectopic kidney (HP:0000086)1.63436065
154Entropion (HP:0000621)1.62813423
155Broad alveolar ridges (HP:0000187)1.60881739
156Impulsivity (HP:0100710)1.60102139
157Protrusio acetabuli (HP:0003179)1.60042493
158Abnormal number of erythroid precursors (HP:0012131)1.59656111
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58608040
160Ascites (HP:0001541)1.58386419
161Abnormality of oral frenula (HP:0000190)1.58306338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.41113990
2WEE13.25663410
3BUB13.00212923
4EEF2K2.90228208
5NEK22.58280849
6PBK2.46231432
7PASK2.45977049
8MST42.41892375
9BRSK22.39421083
10PKN22.38581590
11EIF2AK12.38119246
12TRIM282.31873869
13MAP3K102.11061811
14RPS6KA42.07763011
15STK102.05858014
16SCYL22.04233113
17CDK122.01225730
18NEK11.99743991
19TSSK61.97045621
20BCR1.93196264
21TGFBR11.88807914
22RPS6KB21.79118991
23TTK1.69102746
24ACVR1B1.68972441
25SRPK11.67423290
26MKNK11.66119390
27FLT31.60020962
28ATR1.56819121
29MAP3K81.55844387
30TAF11.55035947
31TESK21.53963309
32EIF2AK31.46452031
33PLK11.44625491
34CDK41.43850170
35DYRK31.39738244
36AURKB1.37047388
37TRIB31.36995926
38CDK71.36783084
39PLK31.35701116
40LRRK21.34223637
41PAK41.33809658
42BRSK11.28399983
43MAP4K11.25447550
44VRK21.20744166
45LATS11.16718446
46CDK61.14520085
47SIK31.13407233
48STK41.12721825
49EIF2AK21.06436596
50CHEK11.05665883
51STK38L1.04350901
52CHEK21.03589828
53NEK91.03489759
54JAK31.00739472
55SMG10.98535979
56NUAK10.96912910
57STK30.96550545
58VRK10.92102099
59EPHA20.92079125
60ALK0.91655163
61CSNK1G10.91067869
62ZAK0.89498931
63PIM10.89274867
64ERBB40.88207441
65TESK10.87810055
66MKNK20.87497624
67CCNB10.86929229
68KSR10.86150601
69ATM0.81939656
70MAP2K30.80271897
71TNIK0.78127781
72BRD40.77826743
73BTK0.77574285
74PLK40.75404621
75CLK10.75381532
76MELK0.74639703
77NME20.73233525
78PTK60.73201237
79CSNK1G30.72169769
80CSNK1A1L0.71961017
81* CDK20.71757691
82STK240.71384196
83AURKA0.68835921
84LATS20.67687021
85FGFR10.67133746
86CDK80.67062977
87PLK20.64633874
88PNCK0.64256575
89MTOR0.62274178
90KDR0.62241894
91TLK10.62140005
92ZAP700.61687517
93DAPK10.58542567
94RAF10.57519111
95WNK30.56393566
96KSR20.56113519
97MAPKAPK30.55136222
98MAP3K90.54554765
99NLK0.52254987
100CDK10.51468806
101BRAF0.50258391
102CDK90.49333347
103MST1R0.48760253
104MET0.48736026
105YES10.48511513
106PDGFRA0.48491363
107CDK140.47176210
108CSNK1G20.47089052
109RPS6KA50.46041105
110BMPR1B0.45952912
111ERBB30.45738742
112CSF1R0.45426954
113CDK180.45368269
114CDK30.44395971
115ERN10.44221924
116CSNK1E0.43930673
117MAP3K140.42522935
118TEC0.42482341
119TTN0.41211187
120CSNK2A20.41061329
121FGFR30.41043311
122ITK0.39206599
123CSNK2A10.38927760
124TYK20.38890006
125NME10.38755511
126CHUK0.37453522
127PAK20.34915096
128MAP3K30.34793809
129CDK150.34686257
130FGFR40.34064042
131MAPK110.33690468
132FRK0.33048499
133RIPK10.32843777
134PAK10.32154058
135FGFR20.31913950
136STK160.31811225
137GRK60.31541327
138CDK11A0.31329824
139AKT20.31312566
140DYRK1B0.29855967
141MARK30.29735353
142CAMK1G0.28543449
143RPS6KA60.27645846
144PRKDC0.27383496
145RPS6KB10.27269645
146MAPKAPK20.26194925

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60536680
2Mismatch repair_Homo sapiens_hsa034303.82006830
3RNA transport_Homo sapiens_hsa030132.98205256
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97161388
5Spliceosome_Homo sapiens_hsa030402.93150761
6Cell cycle_Homo sapiens_hsa041102.92893242
7One carbon pool by folate_Homo sapiens_hsa006702.78559392
8Base excision repair_Homo sapiens_hsa034102.63616088
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56897054
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34718677
11Nucleotide excision repair_Homo sapiens_hsa034202.27230847
12Homologous recombination_Homo sapiens_hsa034402.11778855
13mRNA surveillance pathway_Homo sapiens_hsa030151.80593408
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78366946
15Non-homologous end-joining_Homo sapiens_hsa034501.75516265
16RNA polymerase_Homo sapiens_hsa030201.75402724
17p53 signaling pathway_Homo sapiens_hsa041151.73096575
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71223070
19Pyrimidine metabolism_Homo sapiens_hsa002401.67147030
20RNA degradation_Homo sapiens_hsa030181.64992274
21Fanconi anemia pathway_Homo sapiens_hsa034601.61378153
22Proteasome_Homo sapiens_hsa030501.54216722
23Propanoate metabolism_Homo sapiens_hsa006401.53165495
24Ribosome_Homo sapiens_hsa030101.50944100
25Systemic lupus erythematosus_Homo sapiens_hsa053221.46325699
26Viral carcinogenesis_Homo sapiens_hsa052031.45709353
27Fatty acid elongation_Homo sapiens_hsa000621.43762494
28Antigen processing and presentation_Homo sapiens_hsa046121.41759461
29Vitamin B6 metabolism_Homo sapiens_hsa007501.39518131
30Pyruvate metabolism_Homo sapiens_hsa006201.35200297
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34493685
32Selenocompound metabolism_Homo sapiens_hsa004501.31433226
33Legionellosis_Homo sapiens_hsa051341.29344819
34Herpes simplex infection_Homo sapiens_hsa051681.24616383
35Epstein-Barr virus infection_Homo sapiens_hsa051691.24570453
36Steroid biosynthesis_Homo sapiens_hsa001001.24299649
37Chronic myeloid leukemia_Homo sapiens_hsa052201.20585778
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11488053
39MicroRNAs in cancer_Homo sapiens_hsa052061.09949912
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09641095
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06521763
42Small cell lung cancer_Homo sapiens_hsa052221.06260185
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05560104
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05547286
45HTLV-I infection_Homo sapiens_hsa051661.04818231
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04528034
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03864922
48Thyroid cancer_Homo sapiens_hsa052161.01783534
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01064108
50Basal transcription factors_Homo sapiens_hsa030220.99813054
51Pentose phosphate pathway_Homo sapiens_hsa000300.95176983
52Shigellosis_Homo sapiens_hsa051310.89839719
53Biosynthesis of amino acids_Homo sapiens_hsa012300.89129626
54Hepatitis B_Homo sapiens_hsa051610.88963851
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87318973
56Colorectal cancer_Homo sapiens_hsa052100.87015456
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86882857
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86812629
59Oocyte meiosis_Homo sapiens_hsa041140.85738356
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84585230
61Apoptosis_Homo sapiens_hsa042100.84035718
62Measles_Homo sapiens_hsa051620.83636111
63Leishmaniasis_Homo sapiens_hsa051400.77647779
64N-Glycan biosynthesis_Homo sapiens_hsa005100.74473119
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.74372794
66Purine metabolism_Homo sapiens_hsa002300.71049830
67Notch signaling pathway_Homo sapiens_hsa043300.70662224
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70586606
69Pancreatic cancer_Homo sapiens_hsa052120.69954241
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.68623967
71Non-small cell lung cancer_Homo sapiens_hsa052230.68528247
72Bladder cancer_Homo sapiens_hsa052190.67028323
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66772401
74mTOR signaling pathway_Homo sapiens_hsa041500.66348292
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.65622026
76Primary immunodeficiency_Homo sapiens_hsa053400.64956779
77B cell receptor signaling pathway_Homo sapiens_hsa046620.63335567
78Acute myeloid leukemia_Homo sapiens_hsa052210.62727926
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.62030114
80TGF-beta signaling pathway_Homo sapiens_hsa043500.61662274
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.58677129
82Adherens junction_Homo sapiens_hsa045200.57351460
83Influenza A_Homo sapiens_hsa051640.56908451
84HIF-1 signaling pathway_Homo sapiens_hsa040660.55216581
85Viral myocarditis_Homo sapiens_hsa054160.55195382
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54792290
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54597213
88Fatty acid metabolism_Homo sapiens_hsa012120.54145188
89Proteoglycans in cancer_Homo sapiens_hsa052050.54071579
90Glutathione metabolism_Homo sapiens_hsa004800.52323033
91Toxoplasmosis_Homo sapiens_hsa051450.52260485
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51093684
93Alcoholism_Homo sapiens_hsa050340.50281328
94Hippo signaling pathway_Homo sapiens_hsa043900.50243890
95Prostate cancer_Homo sapiens_hsa052150.47954191
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.47263830
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46648155
98TNF signaling pathway_Homo sapiens_hsa046680.46194971
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45469955
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45079401
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44631523
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43441647
103Wnt signaling pathway_Homo sapiens_hsa043100.42710985
104Carbon metabolism_Homo sapiens_hsa012000.42285032
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42116741
106Tight junction_Homo sapiens_hsa045300.41727057
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40776244
108Pathways in cancer_Homo sapiens_hsa052000.39582594
109Caffeine metabolism_Homo sapiens_hsa002320.38632428
110T cell receptor signaling pathway_Homo sapiens_hsa046600.36320298
111Osteoclast differentiation_Homo sapiens_hsa043800.36136619
112FoxO signaling pathway_Homo sapiens_hsa040680.35999166
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35784671
114Lysine degradation_Homo sapiens_hsa003100.35476729
115Arginine and proline metabolism_Homo sapiens_hsa003300.35325244
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34834658
117Endometrial cancer_Homo sapiens_hsa052130.34600562
118Protein export_Homo sapiens_hsa030600.34180543
119Hematopoietic cell lineage_Homo sapiens_hsa046400.33738029
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.33316639
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31672612
122Folate biosynthesis_Homo sapiens_hsa007900.30072001
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.29934916
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27035249
125Metabolic pathways_Homo sapiens_hsa011000.21671737
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20371406
127Hedgehog signaling pathway_Homo sapiens_hsa043400.20318417
128Sulfur metabolism_Homo sapiens_hsa009200.19639512
129Galactose metabolism_Homo sapiens_hsa000520.18994311
130Vibrio cholerae infection_Homo sapiens_hsa051100.17978352
131beta-Alanine metabolism_Homo sapiens_hsa004100.17315311
132Arginine biosynthesis_Homo sapiens_hsa002200.15995490
133Butanoate metabolism_Homo sapiens_hsa006500.14731145
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13479590
135Fructose and mannose metabolism_Homo sapiens_hsa000510.13166712
136Fatty acid degradation_Homo sapiens_hsa000710.12506495

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