API5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.33236461
2L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.94792635
3DNA deamination (GO:0045006)4.62913960
4L-methionine biosynthetic process (GO:0071265)4.21537030
5amino acid salvage (GO:0043102)4.21537030
6L-methionine salvage (GO:0071267)4.21537030
7regulation of hexokinase activity (GO:1903299)3.92092306
8regulation of glucokinase activity (GO:0033131)3.92092306
9lactate metabolic process (GO:0006089)3.91905321
10cytidine deamination (GO:0009972)3.81123603
11cytidine metabolic process (GO:0046087)3.81123603
12cytidine catabolic process (GO:0006216)3.81123603
13regulation of cellular amino acid metabolic process (GO:0006521)3.80018621
14protein deneddylation (GO:0000338)3.76042941
15preassembly of GPI anchor in ER membrane (GO:0016254)3.73854756
16regulation of DNA endoreduplication (GO:0032875)3.72660654
17cullin deneddylation (GO:0010388)3.61717162
18pyrimidine ribonucleoside catabolic process (GO:0046133)3.58244059
19maturation of 5.8S rRNA (GO:0000460)3.57108255
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55670289
21ribosome assembly (GO:0042255)3.54153516
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49319250
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.44869990
24phosphorylated carbohydrate dephosphorylation (GO:0046838)3.44217812
25inositol phosphate dephosphorylation (GO:0046855)3.44217812
26protein complex biogenesis (GO:0070271)3.44122066
27cellular response to interleukin-15 (GO:0071350)3.41059769
28signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40985749
29signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40985749
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40985749
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40978245
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37276058
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37276058
34protein polyglutamylation (GO:0018095)3.37074133
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34194075
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.34194075
37NADH dehydrogenase complex assembly (GO:0010257)3.34194075
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32551650
39inositol phosphate catabolic process (GO:0071545)3.29785740
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.29199303
41signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29199303
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.23756054
43mitochondrial respiratory chain complex assembly (GO:0033108)3.22058135
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19319491
45protein neddylation (GO:0045116)3.16295115
46pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.15816842
47UMP metabolic process (GO:0046049)3.15816842
48pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.15816842
49UMP biosynthetic process (GO:0006222)3.15816842
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14724343
51negative regulation of ligase activity (GO:0051352)3.14724343
52glucosamine-containing compound catabolic process (GO:1901072)3.14223675
53DNA double-strand break processing (GO:0000729)3.13843805
54regulation of isotype switching to IgG isotypes (GO:0048302)3.09027623
55positive regulation of osteoclast differentiation (GO:0045672)2.99067584
56regulation of interleukin-12 biosynthetic process (GO:0045075)2.96943038
57termination of RNA polymerase III transcription (GO:0006386)2.92056665
58transcription elongation from RNA polymerase III promoter (GO:0006385)2.92056665
59C-terminal protein lipidation (GO:0006501)2.90799639
60protein import into peroxisome matrix (GO:0016558)2.88022688
61protein-cofactor linkage (GO:0018065)2.87868174
62nucleoside diphosphate catabolic process (GO:0009134)2.86844589
63monocyte chemotaxis (GO:0002548)2.86532449
64DNA catabolic process, exonucleolytic (GO:0000738)2.85981853
65chaperone-mediated protein transport (GO:0072321)2.84174406
66viral mRNA export from host cell nucleus (GO:0046784)2.84171191
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82152645
68DNA ligation (GO:0006266)2.81926382
69response to gravity (GO:0009629)2.81067285
70replication fork processing (GO:0031297)2.80467970
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78658549
72regulation of podosome assembly (GO:0071801)2.76395961
73positive regulation of ligase activity (GO:0051351)2.75666947
74folic acid-containing compound biosynthetic process (GO:0009396)2.73376128
75pyrimidine ribonucleoside metabolic process (GO:0046131)2.73324786
76positive regulation of cell cycle arrest (GO:0071158)2.73015647
77regulation of mitochondrial translation (GO:0070129)2.72604555
78respiratory chain complex IV assembly (GO:0008535)2.72603834
79GPI anchor biosynthetic process (GO:0006506)2.71237742
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70918277
81aldehyde catabolic process (GO:0046185)2.70011927
82S-adenosylmethionine metabolic process (GO:0046500)2.69160186
83intracellular protein transmembrane import (GO:0044743)2.67276049
84protein K11-linked deubiquitination (GO:0035871)2.66414337
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.66099578
86negative regulation of neurological system process (GO:0031645)2.65134411
87regulation of fibroblast apoptotic process (GO:2000269)2.64317405
88artery smooth muscle contraction (GO:0014824)2.62868310
89regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.62767308
90positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.62767308
91GPI anchor metabolic process (GO:0006505)2.62531538
92platelet dense granule organization (GO:0060155)2.62490225
93regulation of type B pancreatic cell apoptotic process (GO:2000674)2.59116875
94cytochrome complex assembly (GO:0017004)2.57064244
95energy coupled proton transport, down electrochemical gradient (GO:0015985)2.55945897
96ATP synthesis coupled proton transport (GO:0015986)2.55945897
97establishment of protein localization to mitochondrial membrane (GO:0090151)2.55508238
98methionine biosynthetic process (GO:0009086)2.53947688
99regulation of cellular amine metabolic process (GO:0033238)2.53699519
100positive regulation of organelle assembly (GO:1902117)2.53512202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.86808831
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25131988
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.94651190
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.45799608
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.42844736
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.79571326
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59558228
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55301026
9ELK1_19687146_ChIP-ChIP_HELA_Human2.54475570
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46631001
11VDR_23849224_ChIP-Seq_CD4+_Human2.40095286
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.20668164
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12039602
14TAF15_26573619_Chip-Seq_HEK293_Human2.12016992
15VDR_22108803_ChIP-Seq_LS180_Human2.09897973
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07388040
17ZNF274_21170338_ChIP-Seq_K562_Hela2.07025868
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.00709869
19EWS_26573619_Chip-Seq_HEK293_Human1.98956179
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.98376825
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98206538
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95377783
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92419278
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.89434542
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85920181
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80943109
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80269921
28FOXP3_21729870_ChIP-Seq_TREG_Human1.77352721
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.74580865
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72990642
31FUS_26573619_Chip-Seq_HEK293_Human1.72548048
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71198625
33DCP1A_22483619_ChIP-Seq_HELA_Human1.70644604
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68254766
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65238124
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61484536
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60341755
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60055811
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.56688229
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51863654
41P300_19829295_ChIP-Seq_ESCs_Human1.35915176
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34799184
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31623829
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31133194
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29390546
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28387711
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.27189807
48TP53_22573176_ChIP-Seq_HFKS_Human1.25185496
49SOX2_19829295_ChIP-Seq_ESCs_Human1.21685394
50NANOG_19829295_ChIP-Seq_ESCs_Human1.21685394
51TCF4_22108803_ChIP-Seq_LS180_Human1.21038971
52SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17027681
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.15627759
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.15100118
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.13683086
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12667322
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12234240
58MYC_18940864_ChIP-ChIP_HL60_Human1.11503928
59CDX2_22108803_ChIP-Seq_LS180_Human1.10287907
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10055263
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10001795
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.09386380
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09386380
64SALL4_22934838_ChIP-ChIP_CD34+_Human1.09150663
65CIITA_25753668_ChIP-Seq_RAJI_Human1.09067517
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08696614
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08471689
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07937862
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06574997
70GABP_19822575_ChIP-Seq_HepG2_Human1.04794143
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04505794
72P300_18555785_Chip-Seq_ESCs_Mouse1.04243133
73NCOR_22424771_ChIP-Seq_293T_Human1.03419723
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01792771
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01260116
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01205953
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.00777555
78CBP_20019798_ChIP-Seq_JUKART_Human0.99537933
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99537933
80P53_22387025_ChIP-Seq_ESCs_Mouse0.99107801
81IRF8_21731497_ChIP-ChIP_J774_Mouse0.98617477
82SOX2_18555785_Chip-Seq_ESCs_Mouse0.97072093
83CMYC_18555785_Chip-Seq_ESCs_Mouse0.96897499
84GATA3_26560356_Chip-Seq_TH1_Human0.95965079
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.95159363
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95040799
87AR_20517297_ChIP-Seq_VCAP_Human0.94933452
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94265507
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93636968
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93295159
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93166461
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92507536
93GATA3_26560356_Chip-Seq_TH2_Human0.92007964
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91800951
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91711054
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91634597
97NMYC_18555785_Chip-Seq_ESCs_Mouse0.91317830
98SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91211908
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90174674
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89652833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.58762964
2MP0001835_abnormal_antigen_presentation2.83550974
3MP0003786_premature_aging2.75814386
4MP0003195_calcinosis2.63923962
5MP0010307_abnormal_tumor_latency2.48273982
6MP0003011_delayed_dark_adaptation2.45792501
7MP0006072_abnormal_retinal_apoptosis2.32543453
8MP0001984_abnormal_olfaction2.25910663
9MP0003878_abnormal_ear_physiology2.19571648
10MP0005377_hearing/vestibular/ear_phenot2.19571648
11MP0005084_abnormal_gallbladder_morpholo2.15406958
12MP0002138_abnormal_hepatobiliary_system2.13835260
13MP0008877_abnormal_DNA_methylation2.03816848
14MP0001873_stomach_inflammation2.01027716
15MP0008057_abnormal_DNA_replication1.88018399
16MP0010094_abnormal_chromosome_stability1.85596055
17MP0002277_abnormal_respiratory_mucosa1.80458574
18MP0009785_altered_susceptibility_to1.79238001
19MP0009333_abnormal_splenocyte_physiolog1.79220590
20MP0002163_abnormal_gland_morphology1.79199883
21MP0000685_abnormal_immune_system1.78382860
22MP0003950_abnormal_plasma_membrane1.76828139
23MP0004145_abnormal_muscle_electrophysio1.75235286
24MP0008875_abnormal_xenobiotic_pharmacok1.71468716
25MP0003646_muscle_fatigue1.70558742
26MP0001968_abnormal_touch/_nociception1.69990354
27MP0004885_abnormal_endolymph1.67692613
28MP0002638_abnormal_pupillary_reflex1.64169771
29MP0001188_hyperpigmentation1.61900573
30MP0001542_abnormal_bone_strength1.59606974
31MP0005000_abnormal_immune_tolerance1.53871503
32MP0005551_abnormal_eye_electrophysiolog1.52835754
33MP0008058_abnormal_DNA_repair1.44112922
34MP0002095_abnormal_skin_pigmentation1.43614513
35MP0002006_tumorigenesis1.40166553
36MP0008872_abnormal_physiological_respon1.39490174
37MP0001800_abnormal_humoral_immune1.38534514
38MP0001905_abnormal_dopamine_level1.35716230
39MP0000013_abnormal_adipose_tissue1.35149560
40MP0002405_respiratory_system_inflammati1.34902342
41MP0003567_abnormal_fetal_cardiomyocyte1.32569269
42MP0002876_abnormal_thyroid_physiology1.31665201
43MP0002736_abnormal_nociception_after1.29755788
44MP0004782_abnormal_surfactant_physiolog1.29317707
45MP0002166_altered_tumor_susceptibility1.27647049
46MP0002160_abnormal_reproductive_system1.26995295
47MP0004147_increased_porphyrin_level1.24246321
48MP0002075_abnormal_coat/hair_pigmentati1.22204032
49MP0003718_maternal_effect1.22116274
50MP0001501_abnormal_sleep_pattern1.21704108
51MP0002148_abnormal_hypersensitivity_rea1.15868673
52MP0000613_abnormal_salivary_gland1.15268370
53MP0000371_diluted_coat_color1.13355879
54MP0000372_irregular_coat_pigmentation1.13212917
55MP0009764_decreased_sensitivity_to1.10067573
56MP0001661_extended_life_span1.07792339
57MP0005075_abnormal_melanosome_morpholog1.07206316
58MP0001243_abnormal_dermal_layer1.07047473
59MP0010234_abnormal_vibrissa_follicle1.06747848
60MP0002723_abnormal_immune_serum1.06328724
61MP0002837_dystrophic_cardiac_calcinosis1.04442157
62MP0005389_reproductive_system_phenotype1.02619474
63MP0000516_abnormal_urinary_system1.02292256
64MP0005367_renal/urinary_system_phenotyp1.02292256
65MP0000427_abnormal_hair_cycle0.99642671
66MP0002933_joint_inflammation0.99633932
67MP0001186_pigmentation_phenotype0.99382288
68MP0000689_abnormal_spleen_morphology0.98490367
69MP0008007_abnormal_cellular_replicative0.98227987
70MP0002693_abnormal_pancreas_physiology0.95287493
71MP0002102_abnormal_ear_morphology0.93341849
72MP0006276_abnormal_autonomic_nervous0.92252168
73MP0001853_heart_inflammation0.91815523
74MP0009745_abnormal_behavioral_response0.91285835
75MP0002938_white_spotting0.89354440
76MP0005310_abnormal_salivary_gland0.88492579
77MP0000703_abnormal_thymus_morphology0.88128213
78MP0006035_abnormal_mitochondrial_morpho0.86913921
79MP0003283_abnormal_digestive_organ0.86761419
80MP0005332_abnormal_amino_acid0.86722484
81MP0005253_abnormal_eye_physiology0.84674500
82MP0001819_abnormal_immune_cell0.84261403
83MP0005645_abnormal_hypothalamus_physiol0.84127748
84MP0005410_abnormal_fertilization0.84099070
85MP0001790_abnormal_immune_system0.83724772
86MP0005387_immune_system_phenotype0.83724772
87MP0002420_abnormal_adaptive_immunity0.83152698
88MP0003806_abnormal_nucleotide_metabolis0.82025456
89MP0006036_abnormal_mitochondrial_physio0.81536534
90MP0003183_abnormal_peptide_metabolism0.80895840
91MP0003724_increased_susceptibility_to0.78723690
92MP0004036_abnormal_muscle_relaxation0.78439205
93MP0005379_endocrine/exocrine_gland_phen0.77920777
94MP0002722_abnormal_immune_system0.77481803
95MP0002272_abnormal_nervous_system0.77013396
96MP0003763_abnormal_thymus_physiology0.75821254
97MP0001119_abnormal_female_reproductive0.73184510
98MP0002398_abnormal_bone_marrow0.71679790
99MP0005174_abnormal_tail_pigmentation0.71375990
100MP0000716_abnormal_immune_system0.70360591

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.17093032
2Large for gestational age (HP:0001520)4.06587283
3IgG deficiency (HP:0004315)3.83074343
4Abnormality of T cell number (HP:0011839)3.79584222
5Thyroiditis (HP:0100646)3.67260772
6Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34332770
7Acute necrotizing encephalopathy (HP:0006965)3.32908252
8Severe combined immunodeficiency (HP:0004430)3.26952649
9Abnormality of the pons (HP:0007361)3.23276780
103-Methylglutaconic aciduria (HP:0003535)3.20847348
11Type I transferrin isoform profile (HP:0003642)3.18668310
12Mitochondrial inheritance (HP:0001427)3.18189936
13Renal Fanconi syndrome (HP:0001994)3.08551546
14Progressive macrocephaly (HP:0004481)3.04982912
15Abnormality of midbrain morphology (HP:0002418)3.00095756
16Molar tooth sign on MRI (HP:0002419)3.00095756
17Increased CSF lactate (HP:0002490)2.95292202
18Conjunctival hamartoma (HP:0100780)2.91807845
19Abolished electroretinogram (ERG) (HP:0000550)2.91419796
20Hypoglycemic seizures (HP:0002173)2.90047825
21Abnormality of T cells (HP:0002843)2.88356260
22Abnormal mitochondria in muscle tissue (HP:0008316)2.84448046
23Acute encephalopathy (HP:0006846)2.80938529
24Hypoproteinemia (HP:0003075)2.80544319
25Pancreatic cysts (HP:0001737)2.80143142
26Stomatitis (HP:0010280)2.79545832
27Increased hepatocellular lipid droplets (HP:0006565)2.76696826
28Anhidrosis (HP:0000970)2.72235191
29Methylmalonic acidemia (HP:0002912)2.61816947
30Hypoplasia of the thymus (HP:0000778)2.61788020
31Ketoacidosis (HP:0001993)2.59460539
32Hepatic necrosis (HP:0002605)2.58777318
33Hepatocellular necrosis (HP:0001404)2.57727815
34Reduced antithrombin III activity (HP:0001976)2.56432570
35Hyperinsulinemic hypoglycemia (HP:0000825)2.56225876
36Lipid accumulation in hepatocytes (HP:0006561)2.52905528
37Nephronophthisis (HP:0000090)2.52830032
38Short tibia (HP:0005736)2.35487262
39Abnormality of eosinophils (HP:0001879)2.34592122
40Combined immunodeficiency (HP:0005387)2.32918767
41Methylmalonic aciduria (HP:0012120)2.28155932
42Brushfield spots (HP:0001088)2.27633291
43Palpebral edema (HP:0100540)2.24707047
44Abnormality of macular pigmentation (HP:0008002)2.24253255
45Hypothermia (HP:0002045)2.23339999
46Abnormality of the renal cortex (HP:0011035)2.22431492
47Cerebral edema (HP:0002181)2.20209564
48Tongue fasciculations (HP:0001308)2.19482318
49Increased serum lactate (HP:0002151)2.17893153
50Pancreatic fibrosis (HP:0100732)2.17186911
51Abnormal glycosylation (HP:0012345)2.16941596
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16941596
53Abnormal protein N-linked glycosylation (HP:0012347)2.16941596
54Abnormal protein glycosylation (HP:0012346)2.16941596
55True hermaphroditism (HP:0010459)2.16887279
56Attenuation of retinal blood vessels (HP:0007843)2.16152021
57Respiratory failure (HP:0002878)2.12998935
58Ketosis (HP:0001946)2.12888258
59Renal cortical cysts (HP:0000803)2.12701690
60Optic disc pallor (HP:0000543)2.12597125
61Prominent metopic ridge (HP:0005487)2.12129432
62Abnormal rod and cone electroretinograms (HP:0008323)2.11291293
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10210346
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10076767
65Medial flaring of the eyebrow (HP:0010747)2.06834941
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.06740678
67Furrowed tongue (HP:0000221)2.05766956
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01561126
69Abnormality of renal resorption (HP:0011038)1.98831387
70Lactic acidosis (HP:0003128)1.98263817
71Epiphyseal stippling (HP:0010655)1.96665900
72Congenital stationary night blindness (HP:0007642)1.95648682
73Abnormality of the renal collecting system (HP:0004742)1.95361634
74Pulmonary fibrosis (HP:0002206)1.92093938
75Abnormality of the renal medulla (HP:0100957)1.91927407
76Duplicated collecting system (HP:0000081)1.91385066
77Abnormality of fatty-acid metabolism (HP:0004359)1.90818472
78Exercise intolerance (HP:0003546)1.90781573
79Hamartoma of the eye (HP:0010568)1.90015472
80Cortical visual impairment (HP:0100704)1.88577777
81Increased serum pyruvate (HP:0003542)1.87984807
82Symptomatic seizures (HP:0011145)1.87041630
83Hyperglycemia (HP:0003074)1.86220544
84Brittle hair (HP:0002299)1.84968142
85Pendular nystagmus (HP:0012043)1.84316247
86Proximal tubulopathy (HP:0000114)1.83872265
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83784916
88Abnormality of the metopic suture (HP:0005556)1.83664841
89Constricted visual fields (HP:0001133)1.83038638
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.82859382
91Aplasia/hypoplasia of the uterus (HP:0008684)1.81070213
92Muscle fibrillation (HP:0010546)1.76474663
93Eosinophilia (HP:0001880)1.76230556
94Hyperphosphaturia (HP:0003109)1.76184562
95Porencephaly (HP:0002132)1.74960088
96Melanoma (HP:0002861)1.73544712
97Delayed CNS myelination (HP:0002188)1.73313835
98Abnormality of the prostate (HP:0008775)1.72935323
99Abnormality of B cell number (HP:0010975)1.72797572
100Lethargy (HP:0001254)1.72511283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.05467088
2EIF2AK34.56844254
3FRK3.45738243
4TSSK63.22331196
5VRK22.84457655
6MST42.58609125
7MAP3K122.56357714
8NUAK12.54378089
9NME12.40735708
10EIF2AK11.97772707
11BUB11.97518068
12LIMK11.90864174
13NEK11.76414117
14PLK31.68321091
15ZAK1.67151983
16GRK11.64142533
17ADRBK21.61543941
18PIM21.45381487
19OXSR11.44902787
20CSNK1G31.36467046
21VRK11.34227627
22TRIM281.33887465
23BCR1.31534269
24BCKDK1.30299143
25CSNK1G11.30076782
26EIF2AK21.29241472
27PLK21.26647997
28TAF11.23796722
29KDR1.17944442
30CSNK1A1L1.14228762
31NME21.11772467
32FGFR21.11305668
33DAPK11.06093037
34STK391.02594605
35ERBB31.02139929
36TLK11.01449698
37MAP2K61.00880573
38MAPKAPK31.00526371
39MYLK1.00482907
40CSNK1G20.98688581
41TESK10.95231111
42PBK0.92133604
43WNK30.91233357
44FLT30.90300111
45SRPK10.88283652
46PASK0.86440447
47PHKG10.86313853
48PHKG20.86313853
49BRSK20.85957560
50PDK20.85825890
51PRKCI0.81650768
52ALK0.77196224
53PRKD30.75523262
54SYK0.74269585
55PIK3CG0.73038243
56STK160.71519549
57PRKCQ0.70318916
58GRK50.65931969
59IRAK40.64853194
60CAMKK20.62084988
61WNK40.61892465
62MAP4K20.61866534
63PRKCE0.61807946
64KIT0.59596794
65CDK190.52031425
66IKBKB0.49504485
67PIM10.47515214
68MAP4K10.45347902
69OBSCN0.44559601
70LCK0.43230864
71BRSK10.39794299
72PINK10.39710889
73CSNK1A10.38499608
74INSRR0.37758183
75CDK30.37244235
76SCYL20.36730433
77LYN0.34621926
78PRKCG0.34383776
79IGF1R0.34380335
80MARK30.34151028
81TIE10.33924558
82STK110.32305478
83TEC0.32260414
84TNK20.31424283
85DYRK20.30532674
86MKNK10.30470047
87DAPK30.30261368
88CSNK2A10.28763696
89MAPK70.28760141
90GRK70.27166892
91FGFR10.26861643
92ABL10.26295391
93ITK0.26178097
94GRK60.25716666
95CSNK2A20.25376263
96CCNB10.25048993
97STK30.24311274
98ATR0.23842754
99ARAF0.23780460
100MAP3K140.23295248

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.29038807
2Protein export_Homo sapiens_hsa030603.12867930
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.72855625
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70753660
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.53439361
6Primary immunodeficiency_Homo sapiens_hsa053402.23530052
7Oxidative phosphorylation_Homo sapiens_hsa001902.20368672
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13236351
9Type I diabetes mellitus_Homo sapiens_hsa049402.00508040
10Propanoate metabolism_Homo sapiens_hsa006401.94994901
11RNA polymerase_Homo sapiens_hsa030201.93853154
12Non-homologous end-joining_Homo sapiens_hsa034501.93516501
13Regulation of autophagy_Homo sapiens_hsa041401.91216644
14Homologous recombination_Homo sapiens_hsa034401.89285207
15Sulfur metabolism_Homo sapiens_hsa009201.87016763
16Butanoate metabolism_Homo sapiens_hsa006501.85699545
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83011803
18Selenocompound metabolism_Homo sapiens_hsa004501.80063086
19Tryptophan metabolism_Homo sapiens_hsa003801.76960049
20Folate biosynthesis_Homo sapiens_hsa007901.70097479
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68345044
22Parkinsons disease_Homo sapiens_hsa050121.64921127
23Rheumatoid arthritis_Homo sapiens_hsa053231.62097988
24Basal transcription factors_Homo sapiens_hsa030221.59508400
25Allograft rejection_Homo sapiens_hsa053301.55693016
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50686124
27Autoimmune thyroid disease_Homo sapiens_hsa053201.44442925
28Peroxisome_Homo sapiens_hsa041461.43386880
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41216187
30Asthma_Homo sapiens_hsa053101.35913894
31Fatty acid elongation_Homo sapiens_hsa000621.35799774
32Nucleotide excision repair_Homo sapiens_hsa034201.34872304
33Antigen processing and presentation_Homo sapiens_hsa046121.33500155
34Graft-versus-host disease_Homo sapiens_hsa053321.31709003
35Pyrimidine metabolism_Homo sapiens_hsa002401.30091858
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.29462743
37Fanconi anemia pathway_Homo sapiens_hsa034601.28363260
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26100145
39RNA degradation_Homo sapiens_hsa030181.25762368
40Purine metabolism_Homo sapiens_hsa002301.22411483
41Mismatch repair_Homo sapiens_hsa034301.19347808
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13676108
43Fatty acid degradation_Homo sapiens_hsa000711.12406585
44DNA replication_Homo sapiens_hsa030301.11816478
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.11732069
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07115370
47One carbon pool by folate_Homo sapiens_hsa006701.02904209
48Huntingtons disease_Homo sapiens_hsa050160.94922346
49Spliceosome_Homo sapiens_hsa030400.93829938
50T cell receptor signaling pathway_Homo sapiens_hsa046600.89483871
51Alzheimers disease_Homo sapiens_hsa050100.86011627
52Collecting duct acid secretion_Homo sapiens_hsa049660.85041292
53Caffeine metabolism_Homo sapiens_hsa002320.84326953
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84041611
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82793117
56RNA transport_Homo sapiens_hsa030130.81992436
57Retinol metabolism_Homo sapiens_hsa008300.77218275
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76313585
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74575952
60Linoleic acid metabolism_Homo sapiens_hsa005910.74444520
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74128314
62Chemical carcinogenesis_Homo sapiens_hsa052040.72158995
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.69815679
64Phototransduction_Homo sapiens_hsa047440.68237975
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67803070
66p53 signaling pathway_Homo sapiens_hsa041150.66440301
67Fatty acid metabolism_Homo sapiens_hsa012120.66272658
68Hematopoietic cell lineage_Homo sapiens_hsa046400.63861656
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62412912
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61328245
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61103583
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59936949
73Measles_Homo sapiens_hsa051620.59127168
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58591344
75Metabolic pathways_Homo sapiens_hsa011000.58004462
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57989424
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54613843
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.53864739
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53365747
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51067338
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49288452
82Sulfur relay system_Homo sapiens_hsa041220.47144904
83Pyruvate metabolism_Homo sapiens_hsa006200.44419910
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42803235
85Vibrio cholerae infection_Homo sapiens_hsa051100.41869628
86Insulin secretion_Homo sapiens_hsa049110.40101682
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38913605
88Ether lipid metabolism_Homo sapiens_hsa005650.38693298
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37042999
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.35358319
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35029418
92Base excision repair_Homo sapiens_hsa034100.33932010
93Carbon metabolism_Homo sapiens_hsa012000.33729926
94Cardiac muscle contraction_Homo sapiens_hsa042600.33499212
95N-Glycan biosynthesis_Homo sapiens_hsa005100.31457923
96Nitrogen metabolism_Homo sapiens_hsa009100.30883050
97Circadian rhythm_Homo sapiens_hsa047100.29546729
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28786685
99Epstein-Barr virus infection_Homo sapiens_hsa051690.28721466
100Herpes simplex infection_Homo sapiens_hsa051680.28345361

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