API5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.87273544
2positive regulation of macrophage differentiation (GO:0045651)6.36773323
3cytidine catabolic process (GO:0006216)6.17671782
4cytidine deamination (GO:0009972)6.17671782
5cytidine metabolic process (GO:0046087)6.17671782
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.24587468
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.17019553
8positive regulation of endothelial cell differentiation (GO:0045603)4.94003732
9negative regulation of thymocyte apoptotic process (GO:0070244)4.92428015
10Peyers patch development (GO:0048541)4.83111429
11mucosal-associated lymphoid tissue development (GO:0048537)4.83111429
12proteasome assembly (GO:0043248)4.79138960
13thalamus development (GO:0021794)4.33763343
14cardiolipin metabolic process (GO:0032048)4.23734571
15glucosamine-containing compound catabolic process (GO:1901072)4.22889912
16regulation of endothelial cell differentiation (GO:0045601)4.02709172
17cellular biogenic amine catabolic process (GO:0042402)3.99539869
18amine catabolic process (GO:0009310)3.99539869
19multicellular organism reproduction (GO:0032504)3.78144878
20polyamine biosynthetic process (GO:0006596)3.75065114
21response to gravity (GO:0009629)3.74140255
22regulation of macrophage differentiation (GO:0045649)3.71049718
23skeletal muscle adaptation (GO:0043501)3.67989785
24muscle atrophy (GO:0014889)3.64077883
25striated muscle atrophy (GO:0014891)3.58412242
26regulation of platelet aggregation (GO:0090330)3.51977270
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.50209690
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50209690
29negative regulation of T cell apoptotic process (GO:0070233)3.49533458
30adenosine metabolic process (GO:0046085)3.42458109
31positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.41129391
32regulation of chronic inflammatory response (GO:0002676)3.38190532
33urate metabolic process (GO:0046415)3.37803135
34platelet dense granule organization (GO:0060155)3.37605436
35negative regulation of organelle assembly (GO:1902116)3.36110628
36amine biosynthetic process (GO:0009309)3.33927678
37preassembly of GPI anchor in ER membrane (GO:0016254)3.27693643
38regulation of homotypic cell-cell adhesion (GO:0034110)3.21030652
39cellular biogenic amine biosynthetic process (GO:0042401)3.20025603
40protein K6-linked ubiquitination (GO:0085020)3.19436220
41mismatch repair (GO:0006298)3.17839186
42polyamine metabolic process (GO:0006595)3.15934152
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.12844766
44positive regulation of natural killer cell mediated immunity (GO:0002717)3.11240888
45folic acid-containing compound biosynthetic process (GO:0009396)3.09412221
46nucleoside diphosphate catabolic process (GO:0009134)3.09152694
47natural killer cell activation (GO:0030101)3.04597229
48protein import into peroxisome matrix (GO:0016558)3.02814762
49negative regulation of calcium ion transport into cytosol (GO:0010523)3.01519153
50regulation of cellular amino acid metabolic process (GO:0006521)2.99956741
51pyrimidine nucleoside catabolic process (GO:0046135)2.98597954
52natural killer cell differentiation (GO:0001779)2.98542679
53positive regulation of interleukin-8 secretion (GO:2000484)2.98025511
54regulation of B cell differentiation (GO:0045577)2.97288389
55regulation of thymocyte apoptotic process (GO:0070243)2.96500419
56tryptophan catabolic process (GO:0006569)2.94415102
57indole-containing compound catabolic process (GO:0042436)2.94415102
58indolalkylamine catabolic process (GO:0046218)2.94415102
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91950436
60monocyte chemotaxis (GO:0002548)2.91376208
61indolalkylamine metabolic process (GO:0006586)2.87321962
62reproduction (GO:0000003)2.86693926
63peroxisome fission (GO:0016559)2.83643810
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83314935
65tryptophan metabolic process (GO:0006568)2.76398233
66positive regulation of defense response to virus by host (GO:0002230)2.72196197
67positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.72148141
68negative regulation of heart rate (GO:0010459)2.70985409
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70235450
70regulation of natural killer cell mediated immunity (GO:0002715)2.70235450
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66517921
72negative regulation of ligase activity (GO:0051352)2.66517921
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63838638
74behavioral response to nicotine (GO:0035095)2.63013059
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60522921
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60522921
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60522921
78regulation of leukocyte mediated cytotoxicity (GO:0001910)2.60307992
79S-adenosylmethionine metabolic process (GO:0046500)2.57689215
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57613461
81negative regulation of lymphocyte apoptotic process (GO:0070229)2.57567865
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56771345
83mannosylation (GO:0097502)2.56228453
84sperm-egg recognition (GO:0035036)2.56120584
85kynurenine metabolic process (GO:0070189)2.56065369
86regulation of sensory perception of pain (GO:0051930)2.55445223
87regulation of sensory perception (GO:0051931)2.55445223
88aggressive behavior (GO:0002118)2.55410989
89regulation of platelet activation (GO:0010543)2.55047999
90positive regulation of B cell differentiation (GO:0045579)2.54197491
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53250361
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53250361
93positive regulation of cell killing (GO:0031343)2.52972759
94regulation of centriole replication (GO:0046599)2.50788796
95myoblast migration (GO:0051451)2.47455410
96cellular response to dexamethasone stimulus (GO:0071549)2.47444224
97positive regulation of humoral immune response (GO:0002922)2.46006110
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.44496139
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.44496139
100negative T cell selection (GO:0043383)2.44426620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.20584882
2VDR_22108803_ChIP-Seq_LS180_Human4.34696617
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88019561
4E2F7_22180533_ChIP-Seq_HELA_Human2.81759044
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74436904
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64548114
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60909190
8IRF1_19129219_ChIP-ChIP_H3396_Human2.57484178
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.41114433
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13292513
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12039386
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06085501
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.03398345
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97808297
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.95420484
16FUS_26573619_Chip-Seq_HEK293_Human1.94029046
17TAF15_26573619_Chip-Seq_HEK293_Human1.90187211
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.82962947
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82429879
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81726741
21IGF1R_20145208_ChIP-Seq_DFB_Human1.76268248
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76074272
23ZNF274_21170338_ChIP-Seq_K562_Hela1.74673349
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.71538882
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71022368
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68326019
27RUNX_20019798_ChIP-Seq_JUKART_Human1.67901263
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.58026009
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.52589801
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51443651
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49983014
32VDR_23849224_ChIP-Seq_CD4+_Human1.49866484
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47744204
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45738349
35CEBPB_22108803_ChIP-Seq_LS180_Human1.43096618
36ER_23166858_ChIP-Seq_MCF-7_Human1.42656876
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39093118
38EZH2_22144423_ChIP-Seq_EOC_Human1.38409189
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.36822624
40TP53_22573176_ChIP-Seq_HFKS_Human1.36031903
41CDX2_22108803_ChIP-Seq_LS180_Human1.35684914
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33300495
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.33062339
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33062339
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.32042056
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.31682500
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.31262591
48GATA3_26560356_Chip-Seq_TH2_Human1.30708752
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28754844
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28383530
51NANOG_20526341_ChIP-Seq_ESCs_Human1.24212235
52GATA1_22025678_ChIP-Seq_K562_Human1.23813257
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.23293452
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22815810
55GATA3_27048872_Chip-Seq_THYMUS_Human1.21167260
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.19707263
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.18323106
58PHF8_20622853_ChIP-Seq_HELA_Human1.17974044
59P300_19829295_ChIP-Seq_ESCs_Human1.17465374
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17119886
61MYB_26560356_Chip-Seq_TH2_Human1.16750695
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15979973
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14849584
64SALL4_22934838_ChIP-ChIP_CD34+_Human1.14722274
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14719818
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14616511
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.13141219
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10973186
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10498095
70TAF2_19829295_ChIP-Seq_ESCs_Human1.10253790
71GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09245669
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09115636
73NFYB_21822215_ChIP-Seq_K562_Human1.08425078
74EWS_26573619_Chip-Seq_HEK293_Human1.08308561
75AR_20517297_ChIP-Seq_VCAP_Human1.07453993
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06540395
77HOXB7_26014856_ChIP-Seq_BT474_Human1.04749217
78ERG_20517297_ChIP-Seq_VCAP_Human1.03918451
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03448350
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02947005
81SMRT_27268052_Chip-Seq_Bcells_Human1.02713631
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01136814
83FOXP3_21729870_ChIP-Seq_TREG_Human1.00367737
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99770921
85TCF4_22108803_ChIP-Seq_LS180_Human0.98082885
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97769384
87TBL1_22424771_ChIP-Seq_293T_Human0.96783093
88SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96012612
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95843453
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.95526075
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95399029
92GATA3_26560356_Chip-Seq_TH1_Human0.95209639
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95026379
94CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94430030
95NCOR_22424771_ChIP-Seq_293T_Human0.94017519
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93751962
97ETV1_20927104_ChIP-Seq_GIST48_Human0.93102268
98RBPJ_21746931_ChIP-Seq_IB4_Human0.90774057
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90693714
100NANOG_19829295_ChIP-Seq_ESCs_Human0.90597718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.99511646
2MP0004145_abnormal_muscle_electrophysio3.73316632
3MP0003878_abnormal_ear_physiology3.03458242
4MP0005377_hearing/vestibular/ear_phenot3.03458242
5MP0002736_abnormal_nociception_after2.95713697
6MP0005085_abnormal_gallbladder_physiolo2.82827377
7MP0005083_abnormal_biliary_tract2.78046044
8MP0001968_abnormal_touch/_nociception2.77294732
9MP0005671_abnormal_response_to2.69663965
10MP0008875_abnormal_xenobiotic_pharmacok2.45478873
11MP0003252_abnormal_bile_duct2.39670920
12MP0003724_increased_susceptibility_to2.31739867
13MP0005464_abnormal_platelet_physiology2.25537155
14MP0001501_abnormal_sleep_pattern2.24211207
15MP0003646_muscle_fatigue2.22030344
16MP0003786_premature_aging2.20379010
17MP0005645_abnormal_hypothalamus_physiol2.17968776
18MP0003011_delayed_dark_adaptation2.10130683
19MP0008057_abnormal_DNA_replication2.09347484
20MP0009764_decreased_sensitivity_to1.96445264
21MP0003195_calcinosis1.92331833
22MP0008004_abnormal_stomach_pH1.87459246
23MP0004036_abnormal_muscle_relaxation1.87420690
24MP0003718_maternal_effect1.81262644
25MP0005365_abnormal_bile_salt1.71834050
26MP0004043_abnormal_pH_regulation1.65904917
27MP0008872_abnormal_physiological_respon1.63686201
28MP0005410_abnormal_fertilization1.61500848
29MP0003959_abnormal_lean_body1.60905292
30MP0000685_abnormal_immune_system1.58551700
31MP0002148_abnormal_hypersensitivity_rea1.53543054
32MP0001835_abnormal_antigen_presentation1.52423337
33MP0009785_altered_susceptibility_to1.46475108
34MP0010094_abnormal_chromosome_stability1.39725506
35MP0000427_abnormal_hair_cycle1.39430065
36MP0003693_abnormal_embryo_hatching1.31256534
37MP0002006_tumorigenesis1.29568033
38MP0002269_muscular_atrophy1.28390972
39MP0002277_abnormal_respiratory_mucosa1.28017776
40MP0005174_abnormal_tail_pigmentation1.24030767
41MP0005167_abnormal_blood-brain_barrier1.20174757
42MP0005000_abnormal_immune_tolerance1.16408703
43MP0001664_abnormal_digestion1.15812152
44MP0004147_increased_porphyrin_level1.15168168
45MP0002139_abnormal_hepatobiliary_system1.14688004
46MP0001533_abnormal_skeleton_physiology1.11590239
47MP0002160_abnormal_reproductive_system1.08935002
48MP0009697_abnormal_copulation1.07512585
49MP0004084_abnormal_cardiac_muscle1.07472849
50MP0005551_abnormal_eye_electrophysiolog1.05807622
51MP0001727_abnormal_embryo_implantation1.04096978
52MP0001800_abnormal_humoral_immune1.01240017
53MP0002163_abnormal_gland_morphology1.00220884
54MP0001881_abnormal_mammary_gland0.99857006
55MP0002638_abnormal_pupillary_reflex0.98941956
56MP0002095_abnormal_skin_pigmentation0.96894976
57MP0001243_abnormal_dermal_layer0.95995216
58MP0000749_muscle_degeneration0.95471488
59MP0005084_abnormal_gallbladder_morpholo0.94953381
60MP0001661_extended_life_span0.94721069
61MP0002132_abnormal_respiratory_system0.93746470
62MP0000747_muscle_weakness0.93368491
63MP0004957_abnormal_blastocyst_morpholog0.92338440
64MP0001765_abnormal_ion_homeostasis0.91531688
65MP0000230_abnormal_systemic_arterial0.90178989
66MP0005379_endocrine/exocrine_gland_phen0.88486393
67MP0005387_immune_system_phenotype0.88433379
68MP0001790_abnormal_immune_system0.88433379
69MP0001905_abnormal_dopamine_level0.87582707
70MP0003950_abnormal_plasma_membrane0.87493710
71MP0003045_fibrosis0.86223483
72MP0001502_abnormal_circadian_rhythm0.85303869
73MP0002723_abnormal_immune_serum0.85192064
74MP0005389_reproductive_system_phenotype0.83719296
75MP0005319_abnormal_enzyme/_coenzyme0.82566025
76MP0002234_abnormal_pharynx_morphology0.82527637
77MP0003763_abnormal_thymus_physiology0.80756491
78MP0000689_abnormal_spleen_morphology0.80496972
79MP0005075_abnormal_melanosome_morpholog0.79888437
80MP0005636_abnormal_mineral_homeostasis0.77877873
81MP0002106_abnormal_muscle_physiology0.76782018
82MP0002089_abnormal_postnatal_growth/wei0.76747629
83MP0006035_abnormal_mitochondrial_morpho0.75985347
84MP0001485_abnormal_pinna_reflex0.75569599
85MP0005025_abnormal_response_to0.75506476
86MP0002398_abnormal_bone_marrow0.74737701
87MP0002420_abnormal_adaptive_immunity0.74017193
88MP0003137_abnormal_impulse_conducting0.73649304
89MP0000703_abnormal_thymus_morphology0.72688592
90MP0002405_respiratory_system_inflammati0.72282860
91MP0002452_abnormal_antigen_presenting0.72261305
92MP0000627_abnormal_mammary_gland0.72062953
93MP0002876_abnormal_thyroid_physiology0.71698208
94MP0008007_abnormal_cellular_replicative0.70659485
95MP0001986_abnormal_taste_sensitivity0.70651430
96MP0005620_abnormal_muscle_contractility0.69679741
97MP0001819_abnormal_immune_cell0.69588153
98MP0004782_abnormal_surfactant_physiolog0.69418500
99MP0009745_abnormal_behavioral_response0.68884365
100MP0005266_abnormal_metabolism0.67933481

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.26240308
2IgG deficiency (HP:0004315)3.86661499
3Spontaneous hematomas (HP:0007420)3.85556178
43-Methylglutaconic aciduria (HP:0003535)3.77454465
5Congenital stationary night blindness (HP:0007642)3.67320705
6Palpebral edema (HP:0100540)3.55420230
7Severe combined immunodeficiency (HP:0004430)3.50436175
8Rhabdomyolysis (HP:0003201)3.41196164
9Petechiae (HP:0000967)3.26993045
10Conjunctival telangiectasia (HP:0000524)3.24260996
11Thyroiditis (HP:0100646)3.18636406
12Acute necrotizing encephalopathy (HP:0006965)3.15638048
13Abnormal rod and cone electroretinograms (HP:0008323)3.14663484
14Myoglobinuria (HP:0002913)3.06212874
15Abnormality of T cell number (HP:0011839)3.05828633
16Abnormal mitochondria in muscle tissue (HP:0008316)3.01473306
17Elevated erythrocyte sedimentation rate (HP:0003565)3.01414910
18T lymphocytopenia (HP:0005403)2.93334036
19Acute encephalopathy (HP:0006846)2.90566695
20Abnormality of midbrain morphology (HP:0002418)2.81252755
21Molar tooth sign on MRI (HP:0002419)2.81252755
22Tongue fasciculations (HP:0001308)2.76666208
23Abnormality of the vasculature of the conjunctiva (HP:0008054)2.74864902
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.74112966
25Increased IgM level (HP:0003496)2.73600471
26Conjugated hyperbilirubinemia (HP:0002908)2.71670323
27Pancreatic cysts (HP:0001737)2.65936254
28Progressive macrocephaly (HP:0004481)2.65868588
29Increased CSF lactate (HP:0002490)2.65765686
30Vacuolated lymphocytes (HP:0001922)2.62880410
31Mitochondrial inheritance (HP:0001427)2.62576781
32Congenital, generalized hypertrichosis (HP:0004540)2.60418025
33Combined immunodeficiency (HP:0005387)2.58266037
34Abnormality of fatty-acid metabolism (HP:0004359)2.57693474
35Type II lissencephaly (HP:0007260)2.57256963
36Abnormality of B cell number (HP:0010975)2.52751735
37Pancreatic fibrosis (HP:0100732)2.48272319
38Albinism (HP:0001022)2.47525501
39Malignant hyperthermia (HP:0002047)2.46918186
40True hermaphroditism (HP:0010459)2.42351987
41Nephronophthisis (HP:0000090)2.41843503
42Nemaline bodies (HP:0003798)2.41123148
43Epistaxis (HP:0000421)2.37360899
44Periorbital edema (HP:0100539)2.33483455
45Agitation (HP:0000713)2.32935346
46Muscle fibrillation (HP:0010546)2.32204461
47Hypoplasia of the thymus (HP:0000778)2.31379469
48Retinal dysplasia (HP:0007973)2.30423775
49Hepatic necrosis (HP:0002605)2.29991048
50Increased serum lactate (HP:0002151)2.27328788
51Abolished electroretinogram (ERG) (HP:0000550)2.26087307
52Facial edema (HP:0000282)2.25739800
53Pulmonary fibrosis (HP:0002206)2.25610041
54Abnormality of T cells (HP:0002843)2.22474180
55Hepatocellular necrosis (HP:0001404)2.21620724
56Brittle hair (HP:0002299)2.20218079
57Purpura (HP:0000979)2.14641944
58Cerebral edema (HP:0002181)2.14538980
59Abnormality of the labia minora (HP:0012880)2.14210017
60Gingival bleeding (HP:0000225)2.12405500
61Respiratory failure (HP:0002878)2.11285163
62Nausea (HP:0002018)2.10725337
63Autoimmune hemolytic anemia (HP:0001890)2.08299965
64Attenuation of retinal blood vessels (HP:0007843)2.06609640
65Increased intramyocellular lipid droplets (HP:0012240)2.03773635
66Gaze-evoked nystagmus (HP:0000640)2.02100990
67Intrahepatic cholestasis (HP:0001406)2.01696015
68Chronic diarrhea (HP:0002028)2.00599890
69Thyroid-stimulating hormone excess (HP:0002925)1.97902632
70Generalized aminoaciduria (HP:0002909)1.97722649
71Dysautonomia (HP:0002459)1.93481018
72Menorrhagia (HP:0000132)1.93365465
73Fair hair (HP:0002286)1.92022323
74Anhidrosis (HP:0000970)1.91657997
75Late onset (HP:0003584)1.90098420
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89111483
77Severe visual impairment (HP:0001141)1.86477899
78Symptomatic seizures (HP:0011145)1.85118722
79Round ear (HP:0100830)1.84953341
80Aplastic anemia (HP:0001915)1.84409840
81Constricted visual fields (HP:0001133)1.84188122
82Abnormality of eosinophils (HP:0001879)1.83991863
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.83926107
84Lactic acidosis (HP:0003128)1.83828840
85Hematochezia (HP:0002573)1.83765251
86Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83721784
87Small hand (HP:0200055)1.82776183
88Hypoproteinemia (HP:0003075)1.82366274
89Muscle fiber inclusion bodies (HP:0100299)1.79780698
90Abnormality of the renal cortex (HP:0011035)1.78125184
91Abnormality of alanine metabolism (HP:0010916)1.77374743
92Hyperalaninemia (HP:0003348)1.77374743
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77374743
94Inability to walk (HP:0002540)1.77253189
95Abnormality of purine metabolism (HP:0004352)1.76458686
96Type I transferrin isoform profile (HP:0003642)1.76382100
97Prolonged bleeding time (HP:0003010)1.75265277
98Absent phalangeal crease (HP:0006109)1.73244434
99Gonadotropin excess (HP:0000837)1.72509263
100Distal arthrogryposis (HP:0005684)1.71307831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.86871779
2TIE14.44649796
3MAPKAPK33.37000635
4NME13.02417981
5KDR2.81878933
6NUAK12.61156180
7PIM22.54801225
8ARAF2.51857453
9PHKG12.43177729
10PHKG22.43177729
11TSSK62.40393940
12FRK2.36185238
13TEC2.34333243
14GRK12.20753891
15BUB12.15312509
16ZAK2.09550720
17ADRBK22.05927001
18EIF2AK11.95371181
19BCKDK1.74901405
20EIF2AK31.73310347
21FES1.68681943
22TESK21.55987205
23LIMK11.52757302
24NEK11.48047605
25TLK11.41284457
26TAOK31.39100262
27MST41.39015803
28VRK21.32794673
29MAP3K101.29700096
30DAPK11.28034528
31MYLK1.17832857
32TESK11.14176566
33PTK2B1.09047285
34BMPR1B1.03272678
35OBSCN1.01535458
36CSNK1G31.01274009
37MAP3K120.96994380
38PRKCI0.95746670
39PLK30.94134660
40CSNK1A1L0.91504871
41MAP4K10.90634171
42PLK20.88930860
43RAF10.87131952
44GRK50.85850034
45ALK0.83203804
46SYK0.82880856
47BRAF0.78580680
48WNK40.77782391
49KIT0.76485738
50LMTK20.76055923
51STK160.74059603
52SCYL20.73383733
53CSNK1G20.71461832
54CSNK1G10.71368306
55PIK3CA0.63841587
56INSRR0.63602339
57EIF2AK20.63441626
58ATR0.62445976
59ADRBK10.57953748
60TGFBR20.57925763
61TGFBR10.57200061
62TRPM70.54512451
63TBK10.53260839
64PRKCQ0.52784560
65TNK20.52525887
66PRKCE0.51909879
67CSF1R0.49735929
68GRK60.49628030
69VRK10.49267785
70IRAK40.49130886
71PAK40.49057024
72OXSR10.46585232
73PLK40.45798515
74JAK30.45362503
75MAP4K20.44402815
76AURKA0.43840653
77PAK10.40229617
78BMX0.38770885
79IGF1R0.38116687
80CDK80.37743566
81PBK0.37228821
82IKBKE0.37058548
83PRKCA0.36741725
84STK390.36209246
85CHEK20.35041527
86GRK70.34163715
87ITK0.33433133
88CAMK2A0.33150541
89CDC70.32777842
90LYN0.31375468
91MAPKAPK50.30436507
92LCK0.30026819
93ACVR1B0.29868469
94CSNK2A10.29605815
95MAPK130.29277954
96SRPK10.28740816
97PRKCG0.28705745
98PDK20.28523224
99ZAP700.28384348
100PIM10.27745084

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.12732997
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35530730
3Primary immunodeficiency_Homo sapiens_hsa053402.86849120
4Sulfur metabolism_Homo sapiens_hsa009202.60400807
5One carbon pool by folate_Homo sapiens_hsa006702.55509243
6Caffeine metabolism_Homo sapiens_hsa002322.52265740
7Homologous recombination_Homo sapiens_hsa034402.41889338
8Tryptophan metabolism_Homo sapiens_hsa003802.35097857
9DNA replication_Homo sapiens_hsa030302.30204697
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00788077
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00506040
12Mismatch repair_Homo sapiens_hsa034301.93641280
13Parkinsons disease_Homo sapiens_hsa050121.72534666
14Non-homologous end-joining_Homo sapiens_hsa034501.71371326
15Butanoate metabolism_Homo sapiens_hsa006501.70929936
16Oxidative phosphorylation_Homo sapiens_hsa001901.66051655
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.61041772
18Fatty acid elongation_Homo sapiens_hsa000621.56784653
19Antigen processing and presentation_Homo sapiens_hsa046121.55264782
20Autoimmune thyroid disease_Homo sapiens_hsa053201.54908168
21beta-Alanine metabolism_Homo sapiens_hsa004101.53966992
22Nitrogen metabolism_Homo sapiens_hsa009101.53039277
23Sulfur relay system_Homo sapiens_hsa041221.50662191
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50579317
25Graft-versus-host disease_Homo sapiens_hsa053321.47699762
26Asthma_Homo sapiens_hsa053101.47198224
27Propanoate metabolism_Homo sapiens_hsa006401.41892296
28Type I diabetes mellitus_Homo sapiens_hsa049401.41476793
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.39364135
30Allograft rejection_Homo sapiens_hsa053301.38415336
31Purine metabolism_Homo sapiens_hsa002301.33721669
32Fatty acid degradation_Homo sapiens_hsa000711.31227332
33Phototransduction_Homo sapiens_hsa047441.25423331
34Linoleic acid metabolism_Homo sapiens_hsa005911.23410711
35Hematopoietic cell lineage_Homo sapiens_hsa046401.23229905
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22026750
37Retinol metabolism_Homo sapiens_hsa008301.18373986
38Peroxisome_Homo sapiens_hsa041461.12589944
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09275726
40Cardiac muscle contraction_Homo sapiens_hsa042601.08826999
41Folate biosynthesis_Homo sapiens_hsa007901.07673246
42Alzheimers disease_Homo sapiens_hsa050101.07237485
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02873062
44RNA polymerase_Homo sapiens_hsa030201.01674279
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99891507
46Base excision repair_Homo sapiens_hsa034100.97555522
47Arginine and proline metabolism_Homo sapiens_hsa003300.97030673
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95096853
49Regulation of autophagy_Homo sapiens_hsa041400.92375912
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91917180
51Fanconi anemia pathway_Homo sapiens_hsa034600.91702324
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91332803
53Nucleotide excision repair_Homo sapiens_hsa034200.89450764
54Chemical carcinogenesis_Homo sapiens_hsa052040.88117780
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85158684
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83767121
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83516091
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.82143267
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81303061
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.80147282
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78389911
62Morphine addiction_Homo sapiens_hsa050320.77883458
63Huntingtons disease_Homo sapiens_hsa050160.77476382
64Pyrimidine metabolism_Homo sapiens_hsa002400.76576474
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75271160
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75100048
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73651763
68Platelet activation_Homo sapiens_hsa046110.69960875
69Serotonergic synapse_Homo sapiens_hsa047260.69001478
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67723462
71Olfactory transduction_Homo sapiens_hsa047400.67489313
72Arachidonic acid metabolism_Homo sapiens_hsa005900.65212091
73Glycerolipid metabolism_Homo sapiens_hsa005610.63538850
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63266435
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.55173983
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53778537
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52612392
78Systemic lupus erythematosus_Homo sapiens_hsa053220.52403165
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52194771
80Salivary secretion_Homo sapiens_hsa049700.51317273
81Metabolic pathways_Homo sapiens_hsa011000.50667992
82ABC transporters_Homo sapiens_hsa020100.48540326
83Fatty acid metabolism_Homo sapiens_hsa012120.47451927
84Long-term depression_Homo sapiens_hsa047300.46739657
85Rheumatoid arthritis_Homo sapiens_hsa053230.46053839
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.45622944
87RNA transport_Homo sapiens_hsa030130.45226962
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44932343
89Measles_Homo sapiens_hsa051620.43895856
90Starch and sucrose metabolism_Homo sapiens_hsa005000.41968452
91Tyrosine metabolism_Homo sapiens_hsa003500.41575050
92Viral myocarditis_Homo sapiens_hsa054160.39920012
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38920957
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38490122
95RNA degradation_Homo sapiens_hsa030180.37840897
96Circadian entrainment_Homo sapiens_hsa047130.35924161
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35255554
98p53 signaling pathway_Homo sapiens_hsa041150.34323085
99Phenylalanine metabolism_Homo sapiens_hsa003600.32606636
100Herpes simplex infection_Homo sapiens_hsa051680.32193533

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