APLF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)6.02751153
2cilium or flagellum-dependent cell motility (GO:0001539)5.77449225
3response to pheromone (GO:0019236)5.75347139
4protein targeting to Golgi (GO:0000042)5.68219476
5retrograde transport, vesicle recycling within Golgi (GO:0000301)5.53976201
6kinetochore organization (GO:0051383)5.49320183
7kinetochore assembly (GO:0051382)5.39066531
8CENP-A containing nucleosome assembly (GO:0034080)5.06410252
9chromatin remodeling at centromere (GO:0031055)4.86207389
10thrombin receptor signaling pathway (GO:0070493)4.65250134
11DNA strand renaturation (GO:0000733)4.63875005
12telomere maintenance via semi-conservative replication (GO:0032201)4.56354140
13meiotic chromosome segregation (GO:0045132)4.55615147
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.48268803
15microtubule polymerization or depolymerization (GO:0031109)4.46440831
16mitotic metaphase plate congression (GO:0007080)4.46122490
17sperm motility (GO:0030317)4.45225599
18DNA replication-independent nucleosome organization (GO:0034724)4.33628797
19DNA replication-independent nucleosome assembly (GO:0006336)4.33628797
20DNA replication initiation (GO:0006270)4.23155907
21metaphase plate congression (GO:0051310)4.19171055
22fusion of sperm to egg plasma membrane (GO:0007342)4.18663455
23negative regulation of DNA-dependent DNA replication (GO:2000104)4.15553396
24DNA strand elongation involved in DNA replication (GO:0006271)4.13908380
25telomere maintenance via telomere lengthening (GO:0010833)4.12142553
26protein localization to Golgi apparatus (GO:0034067)4.11858778
27telomere maintenance via recombination (GO:0000722)4.10387509
28DNA replication checkpoint (GO:0000076)4.06953890
29histone exchange (GO:0043486)4.06709714
30protein localization to kinetochore (GO:0034501)4.05091710
31acrosome reaction (GO:0007340)4.02325392
32replication fork processing (GO:0031297)3.99317910
33negative regulation of telomere maintenance (GO:0032205)3.97947933
34DNA strand elongation (GO:0022616)3.96885820
35attachment of spindle microtubules to kinetochore (GO:0008608)3.96086591
36histone mRNA catabolic process (GO:0071044)3.90669437
37mitotic recombination (GO:0006312)3.90408358
38protein K6-linked ubiquitination (GO:0085020)3.75423934
39establishment of chromosome localization (GO:0051303)3.74541577
40protein localization to chromosome, centromeric region (GO:0071459)3.74184510
41mitotic sister chromatid segregation (GO:0000070)3.71026045
42DNA double-strand break processing (GO:0000729)3.68882112
43regulation of telomere maintenance via telomerase (GO:0032210)3.67933724
44seminiferous tubule development (GO:0072520)3.67577296
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.67088741
46regulation of cilium movement (GO:0003352)3.63131047
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57039152
48regulation of DNA endoreduplication (GO:0032875)3.56463637
49microtubule depolymerization (GO:0007019)3.55203057
50regulation of centriole replication (GO:0046599)3.53854393
51proteasome assembly (GO:0043248)3.53456086
52telomere maintenance via telomerase (GO:0007004)3.52550538
53Golgi to endosome transport (GO:0006895)3.50655573
54viral mRNA export from host cell nucleus (GO:0046784)3.50168159
55multicellular organism reproduction (GO:0032504)3.48267270
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.48205668
57axonemal dynein complex assembly (GO:0070286)3.46867674
58regulation of DNA damage checkpoint (GO:2000001)3.46267607
59telomere maintenance (GO:0000723)3.46059328
60telomere organization (GO:0032200)3.45572254
61positive regulation of cAMP-mediated signaling (GO:0043950)3.45480222
62deoxyribonucleotide biosynthetic process (GO:0009263)3.44873684
63piRNA metabolic process (GO:0034587)3.44410991
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.42053533
65positive regulation of developmental pigmentation (GO:0048087)3.38718540
66DNA deamination (GO:0045006)3.38638463
67spindle checkpoint (GO:0031577)3.35337930
68centriole assembly (GO:0098534)3.33930079
69protoporphyrinogen IX metabolic process (GO:0046501)3.33163068
70negative regulation of DNA recombination (GO:0045910)3.32867666
71regulation of meiosis I (GO:0060631)3.32126621
72regulation of centrosome cycle (GO:0046605)3.31760696
73mitotic nuclear envelope disassembly (GO:0007077)3.29301955
74resolution of meiotic recombination intermediates (GO:0000712)3.28988634
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28906664
76sister chromatid segregation (GO:0000819)3.28796371
77neural tube formation (GO:0001841)3.27502057
78plasma membrane fusion (GO:0045026)3.24751646
79intra-Golgi vesicle-mediated transport (GO:0006891)3.24720079
80protein K63-linked deubiquitination (GO:0070536)3.21805805
81protoporphyrinogen IX biosynthetic process (GO:0006782)3.18715568
82termination of RNA polymerase III transcription (GO:0006386)3.17632591
83transcription elongation from RNA polymerase III promoter (GO:0006385)3.17632591
84DNA unwinding involved in DNA replication (GO:0006268)3.15695418
85DNA synthesis involved in DNA repair (GO:0000731)3.15677296
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15587646
87negative regulation of sister chromatid segregation (GO:0033046)3.15587646
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.15587646
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15587646
90spindle assembly checkpoint (GO:0071173)3.15541684
91regulation of DNA-dependent DNA replication (GO:0090329)3.13996386
92centriole replication (GO:0007099)3.13799789
93negative regulation of chromosome segregation (GO:0051985)3.13476852
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12475799
95tyrosine phosphorylation of STAT protein (GO:0007260)3.12082322
96DNA ligation (GO:0006266)3.11885984
97spermatid development (GO:0007286)3.11614469
98mitotic chromosome condensation (GO:0007076)3.10399661
99protein K48-linked deubiquitination (GO:0071108)3.09796919
100microtubule severing (GO:0051013)3.08291823
101cell wall macromolecule catabolic process (GO:0016998)3.07034215
102positive regulation of DNA-dependent DNA replication (GO:2000105)3.06797872
103regulation of spindle organization (GO:0090224)3.06289029
104interkinetic nuclear migration (GO:0022027)3.05774733
105mismatch repair (GO:0006298)3.04372119
106regulation of pigment cell differentiation (GO:0050932)3.03524018
107microtubule anchoring (GO:0034453)3.02261992
108histone H2A acetylation (GO:0043968)3.02028561
109monoubiquitinated protein deubiquitination (GO:0035520)3.01562086
110mitotic spindle assembly checkpoint (GO:0007094)3.01248787
111microtubule nucleation (GO:0007020)3.01215908
112indolalkylamine metabolic process (GO:0006586)2.99830301
113chromosome segregation (GO:0007059)2.99589623
114chromatin assembly or disassembly (GO:0006333)2.99258837
115DNA replication-dependent nucleosome assembly (GO:0006335)2.97818442
116DNA replication-dependent nucleosome organization (GO:0034723)2.97818442
117DNA catabolic process, exonucleolytic (GO:0000738)2.96966788
118recombinational repair (GO:0000725)2.96852161
119nuclear envelope disassembly (GO:0051081)2.96729678
120membrane disassembly (GO:0030397)2.96729678
121mitotic spindle checkpoint (GO:0071174)2.96595776
122protein K11-linked deubiquitination (GO:0035871)2.96095493
123positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.95969389
124cell wall macromolecule metabolic process (GO:0044036)2.95339082
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94728600
126regulation of telomere maintenance (GO:0032204)2.93356283
127protein localization to chromosome (GO:0034502)2.93264095
128DNA replication (GO:0006260)2.92918802
129* single strand break repair (GO:0000012)2.92516143
130double-strand break repair via homologous recombination (GO:0000724)2.92029426
131protein polyglutamylation (GO:0018095)2.91215097
132regulation of sarcomere organization (GO:0060297)2.90397485
133DNA methylation involved in gamete generation (GO:0043046)2.90051510
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89860898
135RNA-dependent DNA replication (GO:0006278)2.89203682
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88040987
137intra-S DNA damage checkpoint (GO:0031573)2.87961228
138tryptophan metabolic process (GO:0006568)2.87754007
139indole-containing compound catabolic process (GO:0042436)2.86342050
140indolalkylamine catabolic process (GO:0046218)2.86342050
141tryptophan catabolic process (GO:0006569)2.86342050
142epithelial cilium movement (GO:0003351)2.86297796
143DNA recombination (GO:0006310)2.84276054
144pseudouridine synthesis (GO:0001522)2.83944716
145regulation of chromosome segregation (GO:0051983)2.83006756
146transcription-coupled nucleotide-excision repair (GO:0006283)2.82971110
147ATP-dependent chromatin remodeling (GO:0043044)2.81266341
148cellular response to ethanol (GO:0071361)2.77517452
149regulation of inositol phosphate biosynthetic process (GO:0010919)2.76777245
150retinal cone cell development (GO:0046549)2.76663964
151regulation of establishment of cell polarity (GO:2000114)2.75776369
152regulation of MHC class II biosynthetic process (GO:0045346)2.72627772
153lipid translocation (GO:0034204)2.72208798
154phospholipid translocation (GO:0045332)2.72208798
155photoreceptor cell maintenance (GO:0045494)2.69735019
156phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67967505
157regulation of platelet activation (GO:0010543)2.67519490
158positive regulation of endothelial cell differentiation (GO:0045603)2.65235602
159definitive hemopoiesis (GO:0060216)2.64236623
160negative regulation of neurotransmitter transport (GO:0051589)2.64215123
161cilium movement (GO:0003341)2.63208231
162negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60022652
163negative regulation of translation, ncRNA-mediated (GO:0040033)2.60022652
164regulation of translation, ncRNA-mediated (GO:0045974)2.60022652
165negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.58316618
166detection of light stimulus involved in sensory perception (GO:0050962)2.58240048
167detection of light stimulus involved in visual perception (GO:0050908)2.58240048
168protein targeting to lysosome (GO:0006622)2.57688215
169establishment of protein localization to vacuole (GO:0072666)2.57688215
170protein targeting to vacuole (GO:0006623)2.57688215
171tachykinin receptor signaling pathway (GO:0007217)2.53114247
172purinergic nucleotide receptor signaling pathway (GO:0035590)2.52517770
173male meiosis I (GO:0007141)2.51728671
174amine catabolic process (GO:0009310)2.48256650
175cellular biogenic amine catabolic process (GO:0042402)2.48256650
176male gamete generation (GO:0048232)2.47174979
177spermatogenesis (GO:0007283)2.46985440
178myelin assembly (GO:0032288)2.46266179
179sperm-egg recognition (GO:0035036)2.46053800
180regulation of histone H3-K9 methylation (GO:0051570)2.45615349
181reproduction (GO:0000003)2.45101397
182positive regulation of vasculogenesis (GO:2001214)2.43541094
183male meiosis (GO:0007140)2.42997618
184axoneme assembly (GO:0035082)2.42120740
185regulation of platelet aggregation (GO:0090330)2.41310255
186regulation of endothelial cell differentiation (GO:0045601)2.39613822
187prenylation (GO:0097354)2.37719178
188protein prenylation (GO:0018342)2.37719178
189spermatid nucleus differentiation (GO:0007289)2.36311223
190left/right axis specification (GO:0070986)2.34401205
191NAD biosynthetic process (GO:0009435)2.32644240
192acrosome assembly (GO:0001675)2.32432827
193cilium organization (GO:0044782)2.31851193
194sphingoid metabolic process (GO:0046519)2.30774871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.11453119
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.98795352
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.88811286
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.33243324
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45043736
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.40193502
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.40132276
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.36410052
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.35694523
10GBX2_23144817_ChIP-Seq_PC3_Human3.08392703
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89528882
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.81231010
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.80084298
14TAF15_26573619_Chip-Seq_HEK293_Human2.66770391
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.61667171
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49112238
17VDR_22108803_ChIP-Seq_LS180_Human2.40097276
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30430613
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.29524593
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.26948512
21AR_21909140_ChIP-Seq_LNCAP_Human2.26896810
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.26421877
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26305434
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24803109
25ZNF274_21170338_ChIP-Seq_K562_Hela2.18179015
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17328684
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17241326
28P300_19829295_ChIP-Seq_ESCs_Human2.17079719
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.13812118
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12454003
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07791007
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06761928
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06125649
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.04289941
35VDR_23849224_ChIP-Seq_CD4+_Human2.01901910
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01122514
37GATA1_22025678_ChIP-Seq_K562_Human1.96851779
38SMAD4_21799915_ChIP-Seq_A2780_Human1.95697396
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94362286
40FOXP3_21729870_ChIP-Seq_TREG_Human1.93423766
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93339728
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.92631184
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88808398
44* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.87649060
45STAT3_23295773_ChIP-Seq_U87_Human1.87313710
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85060292
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77858654
48ER_23166858_ChIP-Seq_MCF-7_Human1.75473824
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.73992618
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68354118
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68103597
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67348654
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66978288
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66918762
55CBP_20019798_ChIP-Seq_JUKART_Human1.66918762
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65201228
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.64926595
58TTF2_22483619_ChIP-Seq_HELA_Human1.64110105
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63767562
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63628437
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63140553
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62262141
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61746602
64XRN2_22483619_ChIP-Seq_HELA_Human1.61423477
65AR_25329375_ChIP-Seq_VCAP_Human1.61215239
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61015381
67* TCF4_23295773_ChIP-Seq_U87_Human1.57195962
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56897750
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.55725737
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54853711
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51783241
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51689117
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51281250
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50289080
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49924819
76DCP1A_22483619_ChIP-Seq_HELA_Human1.49688841
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.48358169
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.48307889
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.47888724
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47652611
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46804642
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44685690
83EWS_26573619_Chip-Seq_HEK293_Human1.43785805
84* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42753891
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41370773
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41370773
87ELK1_19687146_ChIP-ChIP_HELA_Human1.41253302
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.39191061
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38859675
90TP53_16413492_ChIP-PET_HCT116_Human1.37184571
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36601561
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.35663763
93BCAT_22108803_ChIP-Seq_LS180_Human1.35151648
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.34037918
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32906852
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32269845
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31030119
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.30906901
99SOX2_19829295_ChIP-Seq_ESCs_Human1.30395613
100NANOG_19829295_ChIP-Seq_ESCs_Human1.30395613
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30059924
102* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29743881
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29646808
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.28482414
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28035134
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26609830
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26609830
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26530997
109CDX2_22108803_ChIP-Seq_LS180_Human1.26528844
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25758031
111MYC_18940864_ChIP-ChIP_HL60_Human1.25376999
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.24943985
113RUNX2_22187159_ChIP-Seq_PCA_Human1.24007834
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23222124
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21376029
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.20990703
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20131906
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19202977
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18479096
120* GABP_19822575_ChIP-Seq_HepG2_Human1.16991696
121TCF4_22108803_ChIP-Seq_LS180_Human1.16971222
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16534103
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16123312
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16024704
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14533904
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14419359
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13322259
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.13068507
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.10539016
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09103496
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08795075
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.08158835
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08080023
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07897183
135CJUN_26792858_Chip-Seq_BT549_Human1.07335370
136SALL4_22934838_ChIP-ChIP_CD34+_Human1.07253671
137PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04984828
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04100880
139PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04058475
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03983282
141TP53_18474530_ChIP-ChIP_U2OS_Human1.03784389
142* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03582103
143EZH2_27294783_Chip-Seq_NPCs_Mouse1.03547909
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03197714
145P300_18555785_Chip-Seq_ESCs_Mouse1.03172532
146GATA1_26923725_Chip-Seq_HPCs_Mouse1.02829851
147SOX2_21211035_ChIP-Seq_LN229_Gbm1.02090053
148CIITA_25753668_ChIP-Seq_RAJI_Human1.01390051
149AR_21572438_ChIP-Seq_LNCaP_Human1.00738773
150YY1_21170310_ChIP-Seq_MESCs_Mouse1.00561243
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99186796
152IGF1R_20145208_ChIP-Seq_DFB_Human0.98452917
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97575288
154RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96591603
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95679045
156FUS_26573619_Chip-Seq_HEK293_Human0.95352286
157ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92245989
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90968320
159SCL_19346495_ChIP-Seq_HPC-7_Human0.90104505
160STAT3_18555785_Chip-Seq_ESCs_Mouse0.87227381
161ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84449931
162POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83510056
163BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82554321
164SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81669768
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80083543
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79856579
167SOX2_16153702_ChIP-ChIP_HESCs_Human0.79039669
168RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78353393
169OCT4_18555785_Chip-Seq_ESCs_Mouse0.77583775
170LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76802909
171EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76066063
172IRF1_19129219_ChIP-ChIP_H3396_Human0.76050106
173SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74459276
174KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74432435
175ZFX_18555785_Chip-Seq_ESCs_Mouse0.74171748
176CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73741018
177NMYC_18555785_Chip-Seq_ESCs_Mouse0.73441631
178ESRRB_18555785_Chip-Seq_ESCs_Mouse0.72504451
179ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72482795
180KLF4_18555785_Chip-Seq_ESCs_Mouse0.71970200
181EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.70982684
182P53_22387025_ChIP-Seq_ESCs_Mouse0.70068676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.64750253
2MP0010094_abnormal_chromosome_stability4.61116648
3MP0000569_abnormal_digit_pigmentation4.11902233
4MP0003693_abnormal_embryo_hatching4.10027072
5MP0008058_abnormal_DNA_repair3.92276721
6MP0005410_abnormal_fertilization3.84692099
7MP0005464_abnormal_platelet_physiology3.60881321
8MP0000566_synostosis3.60419092
9MP0003077_abnormal_cell_cycle3.36125440
10MP0004147_increased_porphyrin_level3.26251594
11MP0002102_abnormal_ear_morphology3.23943186
12MP0006292_abnormal_olfactory_placode3.21814431
13MP0002396_abnormal_hematopoietic_system3.21214943
14MP0004957_abnormal_blastocyst_morpholog3.21126743
15MP0008057_abnormal_DNA_replication3.00873747
16MP0003195_calcinosis2.84508761
17MP0008877_abnormal_DNA_methylation2.79101958
18MP0001188_hyperpigmentation2.74891602
19MP0003950_abnormal_plasma_membrane2.73141445
20MP0004510_myositis2.62338691
21MP0008007_abnormal_cellular_replicative2.43629751
22MP0003656_abnormal_erythrocyte_physiolo2.39326651
23MP0003786_premature_aging2.38529884
24MP0003724_increased_susceptibility_to2.24985415
25MP0004484_altered_response_of2.22849658
26MP0002735_abnormal_chemical_nociception2.16591952
27MP0005187_abnormal_penis_morphology2.14794226
28MP0003941_abnormal_skin_development2.13791846
29MP0008004_abnormal_stomach_pH2.11072746
30MP0004084_abnormal_cardiac_muscle2.10312242
31MP0003136_yellow_coat_color2.09619745
32MP0000490_abnormal_crypts_of2.08176833
33MP0008932_abnormal_embryonic_tissue2.04454414
34MP0003646_muscle_fatigue2.02693463
35MP0004215_abnormal_myocardial_fiber1.90664179
36MP0008775_abnormal_heart_ventricle1.89891765
37MP0003718_maternal_effect1.77527057
38MP0001968_abnormal_touch/_nociception1.69904777
39MP0002009_preneoplasia1.67749712
40MP0005670_abnormal_white_adipose1.61920049
41MP0002638_abnormal_pupillary_reflex1.61054170
42MP0002210_abnormal_sex_determination1.56415582
43MP0002837_dystrophic_cardiac_calcinosis1.49920091
44MP0004036_abnormal_muscle_relaxation1.49364133
45MP0005551_abnormal_eye_electrophysiolog1.48263838
46MP0005084_abnormal_gallbladder_morpholo1.47160047
47MP0002132_abnormal_respiratory_system1.45350167
48MP0000350_abnormal_cell_proliferation1.45025441
49MP0000230_abnormal_systemic_arterial1.43130392
50MP0008995_early_reproductive_senescence1.42646395
51MP0009764_decreased_sensitivity_to1.35459716
52MP0001986_abnormal_taste_sensitivity1.35451316
53MP0010386_abnormal_urinary_bladder1.34392714
54MP0000383_abnormal_hair_follicle1.32633357
55MP0005171_absent_coat_pigmentation1.32258166
56MP0001929_abnormal_gametogenesis1.30121977
57MP0000049_abnormal_middle_ear1.28664751
58MP0008260_abnormal_autophagy1.28211909
59MP0005310_abnormal_salivary_gland1.26490004
60MP0003045_fibrosis1.25614136
61MP0001145_abnormal_male_reproductive1.24185835
62MP0005395_other_phenotype1.21625419
63MP0000313_abnormal_cell_death1.21245481
64MP0000653_abnormal_sex_gland1.20863007
65MP0002095_abnormal_skin_pigmentation1.18625590
66MP0002138_abnormal_hepatobiliary_system1.16854372
67MP0001835_abnormal_antigen_presentation1.15878315
68MP0000427_abnormal_hair_cycle1.14355472
69MP0004130_abnormal_muscle_cell1.11530149
70MP0001730_embryonic_growth_arrest1.11243749
71MP0005253_abnormal_eye_physiology1.10778716
72MP0001293_anophthalmia1.09519375
73MP0001501_abnormal_sleep_pattern1.09427293
74MP0002332_abnormal_exercise_endurance1.09078196
75MP0000015_abnormal_ear_pigmentation1.08770334
76MP0003868_abnormal_feces_composition1.08240762
77MP0005647_abnormal_sex_gland1.07798611
78MP0001119_abnormal_female_reproductive1.06925620
79MP0005397_hematopoietic_system_phenotyp1.06448759
80MP0001545_abnormal_hematopoietic_system1.06448759
81MP0001672_abnormal_embryogenesis/_devel1.05780523
82MP0005380_embryogenesis_phenotype1.05780523
83MP0002938_white_spotting1.01463717
84MP0003937_abnormal_limbs/digits/tail_de1.00168204
85MP0002085_abnormal_embryonic_tissue0.97888437
86MP0002019_abnormal_tumor_incidence0.97508401
87MP0003698_abnormal_male_reproductive0.96600575
88MP0004808_abnormal_hematopoietic_stem0.96381785
89MP0002148_abnormal_hypersensitivity_rea0.95720902
90MP0002277_abnormal_respiratory_mucosa0.95543456
91MP0005174_abnormal_tail_pigmentation0.95474535
92MP0002168_other_aberrant_phenotype0.93748924
93MP0002254_reproductive_system_inflammat0.93513208
94MP0001879_abnormal_lymphatic_vessel0.92809254
95MP0003121_genomic_imprinting0.90600024
96MP0003938_abnormal_ear_development0.90276404
97MP0002127_abnormal_cardiovascular_syste0.89535379
98MP0001697_abnormal_embryo_size0.88301964
99MP0003763_abnormal_thymus_physiology0.87894185
100MP0008872_abnormal_physiological_respon0.87623922
101MP0002398_abnormal_bone_marrow0.86974259
102MP0004085_abnormal_heartbeat0.86814495
103MP0000372_irregular_coat_pigmentation0.86116818
104MP0000703_abnormal_thymus_morphology0.85996147
105MP0003828_pulmonary_edema0.85629717
106MP0003787_abnormal_imprinting0.85161717
107MP0001486_abnormal_startle_reflex0.85036653
108MP0001346_abnormal_lacrimal_gland0.84447600
109MP0001919_abnormal_reproductive_system0.84093324
110MP0001529_abnormal_vocalization0.84003851
111MP0003315_abnormal_perineum_morphology0.82224664
112MP0003984_embryonic_growth_retardation0.80487019
113MP0002163_abnormal_gland_morphology0.80470446
114MP0000762_abnormal_tongue_morphology0.80157247
115MP0005646_abnormal_pituitary_gland0.79941603
116MP0005620_abnormal_muscle_contractility0.78868799
117MP0002722_abnormal_immune_system0.78536270
118MP0001186_pigmentation_phenotype0.77913311
119MP0000689_abnormal_spleen_morphology0.75920750
120MP0002088_abnormal_embryonic_growth/wei0.75772241
121MP0003123_paternal_imprinting0.75616192
122MP0009333_abnormal_splenocyte_physiolog0.75456637
123MP0002080_prenatal_lethality0.75387890
124MP0001286_abnormal_eye_development0.75276997
125MP0010329_abnormal_lipoprotein_level0.74537389
126MP0009046_muscle_twitch0.74045654
127MP0003890_abnormal_embryonic-extraembry0.73703125
128MP0003943_abnormal_hepatobiliary_system0.72815469
129MP0002736_abnormal_nociception_after0.72643957
130MP0002229_neurodegeneration0.71448639
131MP0006276_abnormal_autonomic_nervous0.71382622
132MP0002084_abnormal_developmental_patter0.70887404
133MP0000516_abnormal_urinary_system0.70033440
134MP0005367_renal/urinary_system_phenotyp0.70033440
135MP0003699_abnormal_female_reproductive0.69140855
136MP0004381_abnormal_hair_follicle0.67820470
137MP0009697_abnormal_copulation0.67751654
138MP0005167_abnormal_blood-brain_barrier0.67577764
139MP0003252_abnormal_bile_duct0.66770217
140MP0009780_abnormal_chondrocyte_physiolo0.66726598
141MP0006054_spinal_hemorrhage0.66714150
142MP0000026_abnormal_inner_ear0.66443607
143MP0002161_abnormal_fertility/fecundity0.66054148
144MP0004742_abnormal_vestibular_system0.65323643
145MP0005389_reproductive_system_phenotype0.65031443
146MP0002733_abnormal_thermal_nociception0.64826676
147MP0002429_abnormal_blood_cell0.64585500
148MP0001756_abnormal_urination0.64427788
149MP0002751_abnormal_autonomic_nervous0.63977480
150MP0000465_gastrointestinal_hemorrhage0.63117641
151MP0009115_abnormal_fat_cell0.62987536
152MP0003866_abnormal_defecation0.62578863
153MP0001485_abnormal_pinna_reflex0.62225731
154MP0002086_abnormal_extraembryonic_tissu0.61926359
155MP0005266_abnormal_metabolism0.61381942
156MP0002075_abnormal_coat/hair_pigmentati0.60237422
157MP0004142_abnormal_muscle_tone0.59951233
158MP0001324_abnormal_eye_pigmentation0.58956948
159MP0000647_abnormal_sebaceous_gland0.58130236
160MP0001851_eye_inflammation0.57609441
161MP0002067_abnormal_sensory_capabilities0.57368624
162MP0002160_abnormal_reproductive_system0.57244392
163MP0005220_abnormal_exocrine_pancreas0.57011784
164MP0005075_abnormal_melanosome_morpholog0.56699102
165MP0000462_abnormal_digestive_system0.56549862
166MP0000470_abnormal_stomach_morphology0.56335797
167MP0003567_abnormal_fetal_cardiomyocyte0.52022431
168MP0002116_abnormal_craniofacial_bone0.51902953
169MP0002098_abnormal_vibrissa_morphology0.51607765
170MP0005384_cellular_phenotype0.50555492

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.19102146
2Chromsome breakage (HP:0040012)6.09980348
3Increased mean platelet volume (HP:0011877)4.91690064
4Abnormality of the preputium (HP:0100587)4.88072065
5Prolonged bleeding time (HP:0003010)4.81771702
6Petechiae (HP:0000967)4.56477884
7Abnormal platelet volume (HP:0011876)4.38080717
8Abnormality of the heme biosynthetic pathway (HP:0010472)4.28160235
9Abnormality of chromosome stability (HP:0003220)4.23732367
10Duplicated collecting system (HP:0000081)4.20013609
11Meckel diverticulum (HP:0002245)4.15226253
12Menorrhagia (HP:0000132)4.06405522
13Aplasia/Hypoplasia of the uvula (HP:0010293)4.00520935
14Abnormality of the ileum (HP:0001549)3.96254402
15Abnormality of the renal collecting system (HP:0004742)3.84384407
16Reticulocytopenia (HP:0001896)3.73770354
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.68940563
18Absent/shortened dynein arms (HP:0200106)3.68940563
19Abnormal respiratory epithelium morphology (HP:0012253)3.62173771
20Abnormal respiratory motile cilium morphology (HP:0005938)3.62173771
21Breast hypoplasia (HP:0003187)3.59502811
22Gingival bleeding (HP:0000225)3.58205108
23Abnormality of DNA repair (HP:0003254)3.49640731
24Oral leukoplakia (HP:0002745)3.37183028
25Protruding tongue (HP:0010808)3.30611046
26Birth length less than 3rd percentile (HP:0003561)3.30505972
27Attenuation of retinal blood vessels (HP:0007843)3.25016634
28Duodenal stenosis (HP:0100867)3.24938105
29Small intestinal stenosis (HP:0012848)3.24938105
30Abnormality of the renal cortex (HP:0011035)3.21869645
31Pancreatic fibrosis (HP:0100732)3.16461000
32Hyperventilation (HP:0002883)3.13738070
33Pancreatic cysts (HP:0001737)3.11675458
34Tubulointerstitial nephritis (HP:0001970)3.07602231
35Bone marrow hypocellularity (HP:0005528)3.06614291
36Chronic otitis media (HP:0000389)3.05428734
37Fair hair (HP:0002286)3.05316668
38Epistaxis (HP:0000421)3.04938899
39Purpura (HP:0000979)3.02577494
40Abnormal spermatogenesis (HP:0008669)3.01727538
41Squamous cell carcinoma (HP:0002860)2.98556158
42Abnormal number of erythroid precursors (HP:0012131)2.97627567
43Clubbing of toes (HP:0100760)2.96627062
44Myelodysplasia (HP:0002863)2.93410250
45Absent radius (HP:0003974)2.93115683
46Selective tooth agenesis (HP:0001592)2.92349643
47Abnormality of the renal medulla (HP:0100957)2.89625536
48Azoospermia (HP:0000027)2.83085258
49Chronic hepatic failure (HP:0100626)2.81362302
50Absent thumb (HP:0009777)2.79831445
51Gonadotropin excess (HP:0000837)2.78768532
52Ectopic kidney (HP:0000086)2.74985673
53Absent forearm bone (HP:0003953)2.72004907
54Aplasia involving forearm bones (HP:0009822)2.72004907
55Volvulus (HP:0002580)2.71107065
56Triphalangeal thumb (HP:0001199)2.70603992
57Abnormality of cells of the erythroid lineage (HP:0012130)2.67745730
58Nephroblastoma (Wilms tumor) (HP:0002667)2.67646921
59Duplication of thumb phalanx (HP:0009942)2.64331969
60Hypoplastic ischia (HP:0003175)2.64013008
61Gaze-evoked nystagmus (HP:0000640)2.62858754
62Nephronophthisis (HP:0000090)2.62564838
63Widely spaced teeth (HP:0000687)2.61354921
64Abnormality of the carotid arteries (HP:0005344)2.57822981
65Abnormality of the ischium (HP:0003174)2.57179571
66Abnormality of the duodenum (HP:0002246)2.56147781
67Severe visual impairment (HP:0001141)2.55822058
68Papillary thyroid carcinoma (HP:0002895)2.54333659
69Embryonal renal neoplasm (HP:0011794)2.52191913
70Acanthocytosis (HP:0001927)2.51945578
71Abnormal auditory evoked potentials (HP:0006958)2.46952261
72Renal cortical cysts (HP:0000803)2.46196996
73True hermaphroditism (HP:0010459)2.43045493
74Abnormal rod and cone electroretinograms (HP:0008323)2.42000092
75Bony spicule pigmentary retinopathy (HP:0007737)2.41034387
76Premature graying of hair (HP:0002216)2.39440911
77High pitched voice (HP:0001620)2.37790072
78Microvesicular hepatic steatosis (HP:0001414)2.37717708
79Horseshoe kidney (HP:0000085)2.35302706
80Cerebral hypomyelination (HP:0006808)2.35281474
81Tubulointerstitial abnormality (HP:0001969)2.34552368
82Abnormal ciliary motility (HP:0012262)2.32759318
83Decreased central vision (HP:0007663)2.32567731
84Medial flaring of the eyebrow (HP:0010747)2.32561713
85Abnormality of macular pigmentation (HP:0008002)2.32037103
86Cone-rod dystrophy (HP:0000548)2.29042513
87Congenital sensorineural hearing impairment (HP:0008527)2.28976512
88Short thumb (HP:0009778)2.28208239
89Aplastic anemia (HP:0001915)2.27457480
90Prostate neoplasm (HP:0100787)2.27396154
91Patellar aplasia (HP:0006443)2.26899501
92Abnormal lung lobation (HP:0002101)2.25783053
93Rough bone trabeculation (HP:0100670)2.25359447
94Portal hypertension (HP:0001409)2.24172709
95Abnormal number of incisors (HP:0011064)2.21652853
96Upper limb muscle weakness (HP:0003484)2.21212438
97Drooling (HP:0002307)2.20700389
98IgM deficiency (HP:0002850)2.20130230
99Disproportionate short-trunk short stature (HP:0003521)2.19235023
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.18730454
101Facial cleft (HP:0002006)2.17391947
102Aplasia/Hypoplasia of the earlobes (HP:0009906)2.13737685
103Sloping forehead (HP:0000340)2.13704981
104Impulsivity (HP:0100710)2.13677120
105Hyperlipoproteinemia (HP:0010980)2.11574522
106Pallor (HP:0000980)2.10200822
107Pancytopenia (HP:0001876)2.09497430
108Congenital stationary night blindness (HP:0007642)2.09379223
109Hypoplastic iliac wings (HP:0002866)2.09345431
110Small hand (HP:0200055)2.08817073
111Generalized hypopigmentation of hair (HP:0011358)2.07969613
112Bell-shaped thorax (HP:0001591)2.07672434
113Metaphyseal dysplasia (HP:0100255)2.06056861
114Tracheoesophageal fistula (HP:0002575)2.04904818
115Hypergonadotropic hypogonadism (HP:0000815)2.04574303
116Aplasia/Hypoplasia of the patella (HP:0006498)2.00262437
117Febrile seizures (HP:0002373)2.00035866
118Ureteral duplication (HP:0000073)1.98502904
119Chronic sinusitis (HP:0011109)1.98172472
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97458310
121Abnormality of alanine metabolism (HP:0010916)1.97458310
122Hyperalaninemia (HP:0003348)1.97458310
123Cleft eyelid (HP:0000625)1.97431596
124Congenital hepatic fibrosis (HP:0002612)1.96768850
125Excessive salivation (HP:0003781)1.95518836
126Urethral obstruction (HP:0000796)1.94383217
127Abnormality of the hepatic vasculature (HP:0006707)1.92813340
128Clumsiness (HP:0002312)1.90529737
129Abnormality of the columella (HP:0009929)1.90215385
130Truncal obesity (HP:0001956)1.88497837
131Absent speech (HP:0001344)1.87981903
132Abnormal hair whorl (HP:0010721)1.86909301
133Abnormal trabecular bone morphology (HP:0100671)1.86588619
134Abnormality of reticulocytes (HP:0004312)1.86425192
135Abnormality of the incisor (HP:0000676)1.84849343
136Spontaneous hematomas (HP:0007420)1.84396375
137Hyperkalemia (HP:0002153)1.84236041
138Polydipsia (HP:0001959)1.83059631
139Abnormal drinking behavior (HP:0030082)1.83059631
140Polyuria (HP:0000103)1.82090946
141Tubular atrophy (HP:0000092)1.80078637
142Molar tooth sign on MRI (HP:0002419)1.79446984
143Abnormality of midbrain morphology (HP:0002418)1.79446984
144Nephrogenic diabetes insipidus (HP:0009806)1.79419599
145Medulloblastoma (HP:0002885)1.79096955
146Abnormal respiratory motile cilium physiology (HP:0012261)1.79044068
147Leukopenia (HP:0001882)1.78665840
148Pendular nystagmus (HP:0012043)1.78396822
149Type 2 muscle fiber atrophy (HP:0003554)1.78359173
150Median cleft lip (HP:0000161)1.77499851
151Nasolacrimal duct obstruction (HP:0000579)1.76940830
152Cutaneous photosensitivity (HP:0000992)1.76813729
15311 pairs of ribs (HP:0000878)1.76810475
154Broad-based gait (HP:0002136)1.75155125
155Dyschromatopsia (HP:0007641)1.74245995
156Atonic seizures (HP:0010819)1.73768706
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73748268
158Central scotoma (HP:0000603)1.73680676
159Hip dysplasia (HP:0001385)1.73332937
160Recurrent sinusitis (HP:0011108)1.73065347
161Hypopigmented skin patches (HP:0001053)1.73010276
162Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72939006
163Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71462187
164Conjunctival telangiectasia (HP:0000524)1.71378564
165Congenital primary aphakia (HP:0007707)1.70661604
166Abnormality of T cell number (HP:0011839)1.70542737
167Genital tract atresia (HP:0001827)1.70006935
168Short middle phalanx of the 5th finger (HP:0004220)1.69740424
169Inability to walk (HP:0002540)1.69178068
170Thyroid-stimulating hormone excess (HP:0002925)1.69128993
171Flat capital femoral epiphysis (HP:0003370)1.68810948
172Renal agenesis (HP:0000104)1.68517995
173T lymphocytopenia (HP:0005403)1.68320666
174Constricted visual fields (HP:0001133)1.67979626
175Tinnitus (HP:0000360)1.67603303
176Impaired platelet aggregation (HP:0003540)1.67557420
177Abnormal platelet function (HP:0011869)1.67557420
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.67499264
179Embryonal neoplasm (HP:0002898)1.66305353
180Autoimmune hemolytic anemia (HP:0001890)1.66276744
181Agnosia (HP:0010524)1.66265450
182Lymphoma (HP:0002665)1.66129752
183Aplasia/Hypoplasia of the sternum (HP:0006714)1.65795126
184Acute myeloid leukemia (HP:0004808)1.64026574
185Abnormality of the lacrimal duct (HP:0011481)1.60282866
186White forelock (HP:0002211)1.60174199
187Premature ovarian failure (HP:0008209)1.59838430
188Patchy hypopigmentation of hair (HP:0011365)1.58163491
189Abnormality of pyrimidine metabolism (HP:0004353)1.57777705
190Cafe-au-lait spot (HP:0000957)1.56569354
191Pulmonary fibrosis (HP:0002206)1.54616078
192Aganglionic megacolon (HP:0002251)1.54490340
193Poikilocytosis (HP:0004447)1.54155383
194Increased nuchal translucency (HP:0010880)1.54077492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK4.25909414
2FRK4.23915988
3BUB13.94172415
4EIF2AK13.93793620
5INSRR3.71379801
6CDC73.49713585
7STK163.20114293
8PLK43.07691793
9NEK22.95242158
10WEE12.91083270
11SRPK12.88817598
12MAP4K22.87940424
13PIK3CG2.63115280
14EIF2AK22.50090839
15ZAK2.23919233
16ATR2.09093743
17PLK12.07072859
18TAOK31.96106671
19PLK21.94362498
20STK38L1.79641084
21AKT31.78114931
22CHEK21.71720556
23MKNK21.67457780
24CDK71.63481741
25CCNB11.63327270
26AURKB1.60181857
27TLK11.60080721
28CLK11.58567735
29LATS11.55950001
30DYRK31.54271526
31VRK11.52041321
32CDK81.51594816
33ACVR1B1.42927436
34MAP3K61.41936931
35PINK11.39310145
36FLT31.33784506
37BRSK21.33523470
38PNCK1.31861509
39STK101.31169188
40MKNK11.30849507
41BRD41.29392525
42EIF2AK31.23293012
43OBSCN1.22312880
44CDK121.22217340
45PLK31.21487984
46NLK1.20377866
47CHEK11.19457693
48AURKA1.18921882
49SGK21.17700562
50PTK2B1.15660006
51STK31.15333343
52BMPR1B1.14610861
53MAP3K41.14537942
54WNK31.12301725
55CAMKK21.10138849
56BRSK11.08226667
57STK41.07948622
58BRAF1.07741384
59YES11.07449147
60PBK1.04207591
61BLK1.03573972
62IRAK11.03156484
63RIPK41.00974677
64STK391.00971995
65BMPR20.99859507
66* ATM0.99401408
67GRK70.99281321
68TSSK60.98302376
69EPHA30.94477712
70CDK40.93479278
71MAP3K80.92619246
72FER0.90745653
73MST40.89053969
74TXK0.87107192
75CAMK1G0.86755974
76STK240.85870536
77NUAK10.79935860
78IRAK40.79440859
79ERBB30.76406197
80MAP3K100.75118840
81TNIK0.74262816
82MYLK0.73685562
83SYK0.72384953
84CSNK1G10.68879450
85WNK10.68483728
86PAK30.67307202
87TIE10.66148107
88OXSR10.65654247
89CDK10.64706047
90NEK10.64239875
91BTK0.63623084
92CSF1R0.62851749
93PDK10.62344201
94PRKCE0.61834380
95TRIM280.61346496
96MAPK130.60852051
97IKBKB0.59848557
98CDK30.57379093
99PIM10.55695224
100CDK20.55651138
101CDK90.53692414
102MAP3K20.53432338
103RPS6KB20.52593658
104SGK30.51844076
105PRKG10.51713038
106PRKCQ0.51212035
107RPS6KA50.50911786
108GRK10.50833453
109LYN0.49368749
110CASK0.48947188
111PRKAA20.48887051
112MELK0.48076816
113DYRK20.46760668
114STK380.46201511
115MAP2K70.44828690
116TAOK20.44590113
117BMX0.44330495
118CSNK1G20.44109388
119MAP3K50.43836565
120NTRK20.43826332
121CSNK2A10.43707778
122SGK2230.41681777
123SGK4940.41681777
124PDK20.41227538
125CAMK40.40958030
126TRPM70.40503323
127DYRK1A0.40424785
128NME10.39751914
129PIK3CA0.39552448
130NEK90.39064316
131CSNK2A20.38642656
132TGFBR20.38424105
133FGFR40.38009327
134TEC0.37801265
135HCK0.37762764
136DDR20.37639420
137CAMK2A0.37454295
138BCR0.36137501
139ADRBK20.35798080
140RPS6KA40.35795403
141ITK0.35770501
142EGFR0.34537853
143FGFR20.34259861
144JAK30.32762685
145MAPKAPK50.32752659
146IGF1R0.32631792
147CSNK1G30.31845233
148KDR0.28401707
149IRAK30.28399660
150LATS20.26993008
151PRKDC0.26672153
152SIK30.25572358
153TGFBR10.23327382
154AKT10.23273438
155NME20.23180004
156MARK30.22995484
157EPHA20.22680706
158MAPK140.22095664
159CSNK1A1L0.21029418
160ADRBK10.19909846
161PAK10.18882430
162TESK20.18788551

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76929880
2Mismatch repair_Homo sapiens_hsa034303.99360082
3Homologous recombination_Homo sapiens_hsa034403.89814690
4Fanconi anemia pathway_Homo sapiens_hsa034603.78547044
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41999932
6Non-homologous end-joining_Homo sapiens_hsa034503.29790758
7RNA polymerase_Homo sapiens_hsa030203.07807890
8Nucleotide excision repair_Homo sapiens_hsa034203.01831118
9Base excision repair_Homo sapiens_hsa034102.94482859
10Cell cycle_Homo sapiens_hsa041102.75851650
11Platelet activation_Homo sapiens_hsa046112.73475810
12Spliceosome_Homo sapiens_hsa030402.62816696
13Pyrimidine metabolism_Homo sapiens_hsa002402.49416923
14Proteasome_Homo sapiens_hsa030502.32630744
15RNA transport_Homo sapiens_hsa030132.32086705
16Ribosome_Homo sapiens_hsa030102.31848275
17Basal transcription factors_Homo sapiens_hsa030222.17278827
18RNA degradation_Homo sapiens_hsa030181.99736726
19p53 signaling pathway_Homo sapiens_hsa041151.97613022
20Dorso-ventral axis formation_Homo sapiens_hsa043201.89868925
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86291457
22Nitrogen metabolism_Homo sapiens_hsa009101.80714598
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79929920
24One carbon pool by folate_Homo sapiens_hsa006701.64239413
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61267123
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59298900
27Purine metabolism_Homo sapiens_hsa002301.58156049
28Selenocompound metabolism_Homo sapiens_hsa004501.57134588
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53204647
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52323925
31mRNA surveillance pathway_Homo sapiens_hsa030151.50554578
32ABC transporters_Homo sapiens_hsa020101.48312630
33Taste transduction_Homo sapiens_hsa047421.46035566
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43875050
35Fatty acid biosynthesis_Homo sapiens_hsa000611.42476898
36Olfactory transduction_Homo sapiens_hsa047401.41582692
37Butanoate metabolism_Homo sapiens_hsa006501.39406677
38Serotonergic synapse_Homo sapiens_hsa047261.23998581
39Systemic lupus erythematosus_Homo sapiens_hsa053221.23096482
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.21790224
41ECM-receptor interaction_Homo sapiens_hsa045121.09156164
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.08568030
43Glycerolipid metabolism_Homo sapiens_hsa005611.07942839
44Herpes simplex infection_Homo sapiens_hsa051681.06798353
45Epstein-Barr virus infection_Homo sapiens_hsa051691.06366249
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.04736953
47FoxO signaling pathway_Homo sapiens_hsa040680.95547100
48Calcium signaling pathway_Homo sapiens_hsa040200.92021413
49Oocyte meiosis_Homo sapiens_hsa041140.88843624
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.88370502
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88171679
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87638880
53Tryptophan metabolism_Homo sapiens_hsa003800.86898057
54Long-term depression_Homo sapiens_hsa047300.85480333
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85259708
56Hematopoietic cell lineage_Homo sapiens_hsa046400.84518360
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84363750
58Salivary secretion_Homo sapiens_hsa049700.82781332
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79140563
60Caffeine metabolism_Homo sapiens_hsa002320.79079965
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.78944602
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77202873
63Viral carcinogenesis_Homo sapiens_hsa052030.73263409
64Primary immunodeficiency_Homo sapiens_hsa053400.73209382
65Ovarian steroidogenesis_Homo sapiens_hsa049130.72636577
66Measles_Homo sapiens_hsa051620.70830875
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68815625
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68283624
69Inositol phosphate metabolism_Homo sapiens_hsa005620.67609489
70T cell receptor signaling pathway_Homo sapiens_hsa046600.65901027
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64860669
72TNF signaling pathway_Homo sapiens_hsa046680.63156707
73Adherens junction_Homo sapiens_hsa045200.60413026
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60317214
75Propanoate metabolism_Homo sapiens_hsa006400.59674764
76Arachidonic acid metabolism_Homo sapiens_hsa005900.58995294
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57594184
78Vitamin B6 metabolism_Homo sapiens_hsa007500.57443876
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.56163063
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56145254
81MicroRNAs in cancer_Homo sapiens_hsa052060.54893276
82Renin secretion_Homo sapiens_hsa049240.54798260
83Chemokine signaling pathway_Homo sapiens_hsa040620.54538853
84Pancreatic secretion_Homo sapiens_hsa049720.54198327
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52833822
86HTLV-I infection_Homo sapiens_hsa051660.52660136
87Circadian entrainment_Homo sapiens_hsa047130.52255419
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51196234
89Small cell lung cancer_Homo sapiens_hsa052220.51032578
90Type II diabetes mellitus_Homo sapiens_hsa049300.50983922
91Asthma_Homo sapiens_hsa053100.48396428
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47714300
93Huntingtons disease_Homo sapiens_hsa050160.47370226
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46569851
95Pentose phosphate pathway_Homo sapiens_hsa000300.46382777
96Sphingolipid metabolism_Homo sapiens_hsa006000.46208466
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46199100
98Linoleic acid metabolism_Homo sapiens_hsa005910.46160131
99Osteoclast differentiation_Homo sapiens_hsa043800.45872512
100Alcoholism_Homo sapiens_hsa050340.44812171
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.44585732
102Circadian rhythm_Homo sapiens_hsa047100.42988718
103Choline metabolism in cancer_Homo sapiens_hsa052310.41756779
104Type I diabetes mellitus_Homo sapiens_hsa049400.41063075
105Morphine addiction_Homo sapiens_hsa050320.40823840
106Regulation of autophagy_Homo sapiens_hsa041400.40543499
107Peroxisome_Homo sapiens_hsa041460.39545888
108Ras signaling pathway_Homo sapiens_hsa040140.39303253
109Notch signaling pathway_Homo sapiens_hsa043300.39188675
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39171254
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38994394
112Fatty acid elongation_Homo sapiens_hsa000620.38619707
113cAMP signaling pathway_Homo sapiens_hsa040240.38318566
114Influenza A_Homo sapiens_hsa051640.38136121
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38057772
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37706532
117MAPK signaling pathway_Homo sapiens_hsa040100.37674652
118Phototransduction_Homo sapiens_hsa047440.37626212
119Ether lipid metabolism_Homo sapiens_hsa005650.37435259
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37377757
121Allograft rejection_Homo sapiens_hsa053300.37104093
122Apoptosis_Homo sapiens_hsa042100.37060667
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36562472
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36376702
125TGF-beta signaling pathway_Homo sapiens_hsa043500.35356192
126Antigen processing and presentation_Homo sapiens_hsa046120.33227328
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32745196
128Glutathione metabolism_Homo sapiens_hsa004800.32188992
129Renin-angiotensin system_Homo sapiens_hsa046140.32175730
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31088100
131Colorectal cancer_Homo sapiens_hsa052100.30701415
132Hepatitis B_Homo sapiens_hsa051610.30631604
133Autoimmune thyroid disease_Homo sapiens_hsa053200.28352239
134Folate biosynthesis_Homo sapiens_hsa007900.28280320
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28184029
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.26233375
137Basal cell carcinoma_Homo sapiens_hsa052170.25415816
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.25154788
139Hippo signaling pathway_Homo sapiens_hsa043900.24415688
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23839237
141Lysine degradation_Homo sapiens_hsa003100.23730375
142Pathways in cancer_Homo sapiens_hsa052000.22466429
143Vitamin digestion and absorption_Homo sapiens_hsa049770.21909196
144Wnt signaling pathway_Homo sapiens_hsa043100.21829542
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21769781
146Metabolic pathways_Homo sapiens_hsa011000.21127343
147Malaria_Homo sapiens_hsa051440.20843213
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20512319
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.19744194
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.19442242
151Melanoma_Homo sapiens_hsa052180.19236655
152Pancreatic cancer_Homo sapiens_hsa052120.19141191
153Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18264572
154Shigellosis_Homo sapiens_hsa051310.16745612
155Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16086662
156Other glycan degradation_Homo sapiens_hsa005110.15673920
157Legionellosis_Homo sapiens_hsa051340.14066726
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13512683
159N-Glycan biosynthesis_Homo sapiens_hsa005100.09841191
160Bladder cancer_Homo sapiens_hsa052190.09547691
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08994624
162Protein export_Homo sapiens_hsa030600.08408470

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