APLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.39279795
2axon ensheathment in central nervous system (GO:0032291)6.39279795
3synaptic vesicle maturation (GO:0016188)5.38523614
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.88203084
5postsynaptic membrane organization (GO:0001941)4.80421937
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78806129
7locomotory exploration behavior (GO:0035641)4.56826218
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50139223
9synaptic vesicle exocytosis (GO:0016079)4.44107098
10regulation of synaptic vesicle exocytosis (GO:2000300)4.34187802
11positive regulation of synapse maturation (GO:0090129)4.26436190
12cerebellar granule cell differentiation (GO:0021707)4.23696479
13neuron cell-cell adhesion (GO:0007158)4.20358176
14neuronal action potential propagation (GO:0019227)4.17877394
15glutamate secretion (GO:0014047)4.13526568
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04010983
17vocalization behavior (GO:0071625)4.02147145
18dendritic spine morphogenesis (GO:0060997)3.94997724
19regulation of neuronal synaptic plasticity (GO:0048168)3.89668132
20L-amino acid import (GO:0043092)3.88417660
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.86312499
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.85086444
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.84713586
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.79360830
25protein localization to synapse (GO:0035418)3.76220335
26regulation of synaptic vesicle transport (GO:1902803)3.75035994
27glycine transport (GO:0015816)3.73980289
28myelination (GO:0042552)3.68739002
29regulation of glutamate receptor signaling pathway (GO:1900449)3.68658022
30axon ensheathment (GO:0008366)3.67151763
31ensheathment of neurons (GO:0007272)3.67151763
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64448274
33layer formation in cerebral cortex (GO:0021819)3.61352438
34transmission of nerve impulse (GO:0019226)3.60991837
35cerebellar Purkinje cell differentiation (GO:0021702)3.60880645
36negative regulation of neurotransmitter transport (GO:0051589)3.58632093
37positive regulation of neurotransmitter transport (GO:0051590)3.48776374
38neuronal ion channel clustering (GO:0045161)3.48017014
39gamma-aminobutyric acid transport (GO:0015812)3.47665359
40neuron recognition (GO:0008038)3.47587500
41neurotransmitter secretion (GO:0007269)3.46883811
42synaptic transmission, glutamatergic (GO:0035249)3.46113031
43exploration behavior (GO:0035640)3.46009456
44presynaptic membrane organization (GO:0097090)3.44860288
45cell communication by electrical coupling (GO:0010644)3.44116134
46adult walking behavior (GO:0007628)3.41450801
47regulation of synapse structural plasticity (GO:0051823)3.39588151
48cell migration in hindbrain (GO:0021535)3.37120585
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.36838003
50glutamate receptor signaling pathway (GO:0007215)3.36813119
51long-chain fatty acid biosynthetic process (GO:0042759)3.36662319
52regulation of synapse maturation (GO:0090128)3.36640745
53neuron-neuron synaptic transmission (GO:0007270)3.36245986
54negative regulation of neurotransmitter secretion (GO:0046929)3.33390647
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30659894
56pyrimidine nucleobase catabolic process (GO:0006208)3.30151030
57neuromuscular synaptic transmission (GO:0007274)3.29662563
58positive regulation of membrane potential (GO:0045838)3.26066569
59presynaptic membrane assembly (GO:0097105)3.25922820
60long-term memory (GO:0007616)3.25839568
61establishment of mitochondrion localization (GO:0051654)3.23937035
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.23596326
63cellular potassium ion homeostasis (GO:0030007)3.23156033
64membrane depolarization during action potential (GO:0086010)3.22355103
65membrane depolarization (GO:0051899)3.21539115
66positive regulation of neurotransmitter secretion (GO:0001956)3.18766874
67regulation of dendritic spine morphogenesis (GO:0061001)3.16442797
68neuromuscular process controlling posture (GO:0050884)3.16027021
69cellular sodium ion homeostasis (GO:0006883)3.14219437
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13446633
71neuromuscular process controlling balance (GO:0050885)3.12446433
72axonal fasciculation (GO:0007413)3.11262653
73fatty acid elongation (GO:0030497)3.10844535
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10560687
75acidic amino acid transport (GO:0015800)3.09829029
76neurotransmitter transport (GO:0006836)3.09388046
77auditory behavior (GO:0031223)3.08971359
78mating behavior (GO:0007617)3.08843678
79mitochondrion transport along microtubule (GO:0047497)3.08551983
80establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.08551983
81dendrite morphogenesis (GO:0048813)3.08381802
82neurotransmitter uptake (GO:0001504)3.06971544
83regulation of synaptic transmission (GO:0050804)3.06275579
84regulation of synaptic plasticity (GO:0048167)3.04747441
85negative regulation of dendrite morphogenesis (GO:0050774)3.04106750
86regulation of ARF protein signal transduction (GO:0032012)3.03457299
87amino acid import (GO:0043090)3.03297122
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01028516
89peptidyl-tyrosine autophosphorylation (GO:0038083)3.00788454
90establishment of synaptic vesicle localization (GO:0097480)2.99415866
91synaptic vesicle transport (GO:0048489)2.99415866
92nerve growth factor signaling pathway (GO:0038180)2.98014229
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.96999438
94regulation of postsynaptic membrane potential (GO:0060078)2.94830195
95neurotransmitter-gated ion channel clustering (GO:0072578)2.94578796
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93286359
97dendritic spine organization (GO:0097061)2.92166698
98long-term synaptic potentiation (GO:0060291)2.90138562
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89818354
100regulation of neurotransmitter secretion (GO:0046928)2.89046718
101regulation of vesicle fusion (GO:0031338)2.87247516
102membrane hyperpolarization (GO:0060081)2.85702016
103activation of protein kinase A activity (GO:0034199)2.84440801
104regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83392944
105response to auditory stimulus (GO:0010996)2.82553256
106regulation of neurotransmitter levels (GO:0001505)2.82368821
107potassium ion import (GO:0010107)2.81025563
108sodium ion export (GO:0071436)2.80531708
109regulation of voltage-gated calcium channel activity (GO:1901385)2.79393518
110mechanosensory behavior (GO:0007638)2.78891008
111myelin maintenance (GO:0043217)2.78154982
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77931485
113vesicle transport along microtubule (GO:0047496)2.77737650
114regulation of neurotransmitter transport (GO:0051588)2.77712350
115negative regulation of axonogenesis (GO:0050771)2.77671533
116cerebellar Purkinje cell layer development (GO:0021680)2.77102218
117regulation of glutamate secretion (GO:0014048)2.77048054
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.76802021
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76053367
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75370803
121regulation of dendritic spine development (GO:0060998)2.74042418
122organelle transport along microtubule (GO:0072384)2.73971549
123prepulse inhibition (GO:0060134)2.73451242
124potassium ion homeostasis (GO:0055075)2.68634137
125synaptic vesicle endocytosis (GO:0048488)2.67523258
126positive regulation of dendritic spine development (GO:0060999)2.67129828
127regulation of synaptic transmission, GABAergic (GO:0032228)2.66862675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05719195
2GBX2_23144817_ChIP-Seq_PC3_Human3.21938295
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03682316
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97030244
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91280379
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63753898
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63753898
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56013802
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.55182645
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54762986
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53168849
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.48802641
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47876778
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.47187079
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46479648
16DROSHA_22980978_ChIP-Seq_HELA_Human2.43163665
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40446910
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33404729
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.31403189
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.21137638
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.14626918
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.06101159
23RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.97128986
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86249872
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83663674
26AR_21572438_ChIP-Seq_LNCaP_Human1.83050468
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77558259
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76727584
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74972121
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72067071
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64851002
32TAF15_26573619_Chip-Seq_HEK293_Human1.59245138
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59129743
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47178141
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.46185788
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44262571
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42963305
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38811749
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36746512
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35554679
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34642182
42SMAD4_21799915_ChIP-Seq_A2780_Human1.32894498
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.31337639
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30984231
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30062193
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29268274
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29190482
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.27572551
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26099157
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24448773
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22544539
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.21301648
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21187834
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20733533
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19507079
56STAT3_23295773_ChIP-Seq_U87_Human1.17837399
57P300_19829295_ChIP-Seq_ESCs_Human1.16801176
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.16115572
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15829481
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13612960
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11744717
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.11741605
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11299350
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07228458
65ZNF274_21170338_ChIP-Seq_K562_Hela1.06714340
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.06512474
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06001634
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05730587
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05599740
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04608777
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04082667
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03836862
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01614707
74KDM2B_26808549_Chip-Seq_K562_Human1.01013581
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.00941494
76AR_19668381_ChIP-Seq_PC3_Human1.00924860
77TCF4_23295773_ChIP-Seq_U87_Human1.00225559
78ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98948420
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98027336
80ER_23166858_ChIP-Seq_MCF-7_Human0.97680981
81RNF2_27304074_Chip-Seq_NSC_Mouse0.97472678
82ARNT_22903824_ChIP-Seq_MCF-7_Human0.95251114
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95092526
84AR_25329375_ChIP-Seq_VCAP_Human0.94743451
85* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94486316
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94435457
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94155037
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92570931
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.92278884
90AHR_22903824_ChIP-Seq_MCF-7_Human0.92272502
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92100188
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91259832
93VDR_22108803_ChIP-Seq_LS180_Human0.91228840
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91222926
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.90550463
96IGF1R_20145208_ChIP-Seq_DFB_Human0.90130849
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89184911
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.88730670
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88104444
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87966287
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87966287
102POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87869143
103RUNX2_22187159_ChIP-Seq_PCA_Human0.87407850
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.86240528
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85536706
106OCT4_19829295_ChIP-Seq_ESCs_Human0.85153716
107* CTCF_27219007_Chip-Seq_Bcells_Human0.84496998
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84210117
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83274529
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82646225
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82334860
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.82265322
113SMAD4_21741376_ChIP-Seq_EPCs_Human0.82127367
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81881280
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81793210
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81509030
117DPY_21335234_ChIP-Seq_ESCs_Mouse0.81042628
118RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76492837
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76225260
120SOX9_26525672_Chip-Seq_HEART_Mouse0.73763144
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72298161
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69469748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.57013427
2MP0003880_abnormal_central_pattern4.87227994
3MP0004270_analgesia3.99255057
4MP0003635_abnormal_synaptic_transmissio3.69016919
5MP0009745_abnormal_behavioral_response3.11061830
6MP0002064_seizures3.10396026
7MP0002063_abnormal_learning/memory/cond2.91259177
8MP0005423_abnormal_somatic_nervous2.88264199
9MP0002272_abnormal_nervous_system2.83381533
10MP0002822_catalepsy2.79082198
11MP0001486_abnormal_startle_reflex2.77850717
12MP0000920_abnormal_myelination2.75007758
13MP0009046_muscle_twitch2.65502102
14MP0002572_abnormal_emotion/affect_behav2.52806923
15MP0002734_abnormal_mechanical_nocicepti2.50730686
16MP0003329_amyloid_beta_deposits2.43744422
17MP0004885_abnormal_endolymph2.21406218
18MP0001968_abnormal_touch/_nociception2.20660764
19MP0001529_abnormal_vocalization2.16283033
20MP0000778_abnormal_nervous_system2.02305490
21MP0001440_abnormal_grooming_behavior1.93649565
22MP0001970_abnormal_pain_threshold1.91977283
23MP0002733_abnormal_thermal_nociception1.87974056
24MP0008569_lethality_at_weaning1.85910470
25MP0003690_abnormal_glial_cell1.85339654
26MP0001501_abnormal_sleep_pattern1.80079898
27MP0001905_abnormal_dopamine_level1.77134477
28MP0009780_abnormal_chondrocyte_physiolo1.76493756
29MP0004142_abnormal_muscle_tone1.74068104
30MP0000955_abnormal_spinal_cord1.73853090
31MP0002067_abnormal_sensory_capabilities1.72252902
32MP0005386_behavior/neurological_phenoty1.64320390
33MP0004924_abnormal_behavior1.64320390
34MP0003634_abnormal_glial_cell1.59486975
35MP0002736_abnormal_nociception_after1.58681434
36MP0002735_abnormal_chemical_nociception1.58015242
37MP0004811_abnormal_neuron_physiology1.54960269
38MP0002882_abnormal_neuron_morphology1.54843725
39MP0003123_paternal_imprinting1.54309861
40MP0002909_abnormal_adrenal_gland1.52818212
41MP0002557_abnormal_social/conspecific_i1.52515978
42MP0003633_abnormal_nervous_system1.52379212
43MP0002184_abnormal_innervation1.51734456
44MP0005645_abnormal_hypothalamus_physiol1.51313963
45MP0002066_abnormal_motor_capabilities/c1.50496856
46MP0004742_abnormal_vestibular_system1.50352189
47MP0005646_abnormal_pituitary_gland1.46723441
48MP0002229_neurodegeneration1.43531767
49MP0003631_nervous_system_phenotype1.39241781
50MP0004043_abnormal_pH_regulation1.34123098
51MP0001485_abnormal_pinna_reflex1.31419796
52MP0001984_abnormal_olfaction1.30748396
53MP0004858_abnormal_nervous_system1.27114507
54MP0001502_abnormal_circadian_rhythm1.26985690
55MP0003632_abnormal_nervous_system1.23901438
56MP0000013_abnormal_adipose_tissue1.21724705
57MP0005409_darkened_coat_color1.20704675
58MP0002638_abnormal_pupillary_reflex1.20355927
59MP0003121_genomic_imprinting1.20313091
60MP0006276_abnormal_autonomic_nervous1.19341616
61MP0000604_amyloidosis1.12348866
62MP0003122_maternal_imprinting1.11451279
63MP0002152_abnormal_brain_morphology1.11318283
64MP0005171_absent_coat_pigmentation1.09712824
65MP0005551_abnormal_eye_electrophysiolog1.08500392
66MP0003879_abnormal_hair_cell1.04452530
67MP0003787_abnormal_imprinting1.00137479
68MP0004145_abnormal_muscle_electrophysio0.98540844
69MP0003283_abnormal_digestive_organ0.97924430
70MP0001177_atelectasis0.96144907
71MP0001963_abnormal_hearing_physiology0.94578791
72MP0002752_abnormal_somatic_nervous0.92752963
73MP0000566_synostosis0.89938022
74MP0008877_abnormal_DNA_methylation0.89459148
75MP0002069_abnormal_eating/drinking_beha0.89166693
76MP0005410_abnormal_fertilization0.87635620
77MP0005623_abnormal_meninges_morphology0.87061804
78MP0003075_altered_response_to0.86965430
79MP0001299_abnormal_eye_distance/0.85499004
80MP0000631_abnormal_neuroendocrine_gland0.83096237
81MP0000747_muscle_weakness0.77908684
82MP0001346_abnormal_lacrimal_gland0.76985074
83MP0000003_abnormal_adipose_tissue0.75901188
84MP0008874_decreased_physiological_sensi0.74478785
85MP0002090_abnormal_vision0.73572484
86MP0004085_abnormal_heartbeat0.72798992
87MP0003137_abnormal_impulse_conducting0.70124594
88MP0002653_abnormal_ependyma_morphology0.69899117
89MP0001188_hyperpigmentation0.69715994
90MP0005535_abnormal_body_temperature0.69000097
91MP0000751_myopathy0.67776059
92MP0008872_abnormal_physiological_respon0.67353094
93MP0000462_abnormal_digestive_system0.67271992
94MP0006072_abnormal_retinal_apoptosis0.67124621
95MP0001986_abnormal_taste_sensitivity0.66853116
96MP0004147_increased_porphyrin_level0.64574738
97MP0003938_abnormal_ear_development0.64019552
98MP0000579_abnormal_nail_morphology0.62774672
99MP0001664_abnormal_digestion0.62387912
100MP0010769_abnormal_survival0.61188681
101MP0004133_heterotaxia0.60471896
102MP0003172_abnormal_lysosome_physiology0.60413739
103MP0010770_preweaning_lethality0.59773624
104MP0002082_postnatal_lethality0.59773624
105MP0001943_abnormal_respiration0.58756084
106MP0010386_abnormal_urinary_bladder0.58554790
107MP0010768_mortality/aging0.57596719
108MP0005167_abnormal_blood-brain_barrier0.56967433
109MP0005394_taste/olfaction_phenotype0.55022438
110MP0005499_abnormal_olfactory_system0.55022438
111MP0003861_abnormal_nervous_system0.54791954
112MP0003950_abnormal_plasma_membrane0.54207715
113MP0001348_abnormal_lacrimal_gland0.53503307
114MP0003136_yellow_coat_color0.52135470
115MP0000026_abnormal_inner_ear0.51668115
116MP0005253_abnormal_eye_physiology0.51228172
117* MP0003956_abnormal_body_size0.47685540
118MP0000569_abnormal_digit_pigmentation0.47430217

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.37865019
2Focal motor seizures (HP:0011153)5.59506079
3Neurofibrillary tangles (HP:0002185)5.08675487
4Supranuclear gaze palsy (HP:0000605)4.60934406
5Focal seizures (HP:0007359)4.31766321
6Ankle clonus (HP:0011448)4.29011588
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.28848009
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.28848009
9Cerebral inclusion bodies (HP:0100314)4.15757099
10Abnormality of the corticospinal tract (HP:0002492)3.92083039
11Visual hallucinations (HP:0002367)3.89760137
12Spastic gait (HP:0002064)3.65802253
13Dysmetria (HP:0001310)3.64608614
14Action tremor (HP:0002345)3.61425785
15Epileptic encephalopathy (HP:0200134)3.57871298
16Peripheral hypomyelination (HP:0007182)3.40701321
17Atonic seizures (HP:0010819)3.39456478
18Intention tremor (HP:0002080)3.35790262
19Insidious onset (HP:0003587)3.28275885
20Termporal pattern (HP:0011008)3.28275885
21Polyphagia (HP:0002591)3.19018861
22Scanning speech (HP:0002168)3.05952075
23Progressive cerebellar ataxia (HP:0002073)3.04323977
24Megalencephaly (HP:0001355)2.96056457
25Dialeptic seizures (HP:0011146)2.93205430
26Anxiety (HP:0000739)2.91056437
27Absence seizures (HP:0002121)2.90030468
28Generalized tonic-clonic seizures (HP:0002069)2.89922197
29Sleep apnea (HP:0010535)2.89222716
30Depression (HP:0000716)2.81963726
31Onion bulb formation (HP:0003383)2.81643195
32Pheochromocytoma (HP:0002666)2.81412437
33Urinary urgency (HP:0000012)2.81342045
34Broad-based gait (HP:0002136)2.77849101
35Dysdiadochokinesis (HP:0002075)2.76758913
36Urinary bladder sphincter dysfunction (HP:0002839)2.71120950
37Annular pancreas (HP:0001734)2.70495272
38Status epilepticus (HP:0002133)2.69798843
39Hemiplegia (HP:0002301)2.68743250
40Limb dystonia (HP:0002451)2.67838522
41Cerebral hypomyelination (HP:0006808)2.66505294
42Impaired vibration sensation in the lower limbs (HP:0002166)2.66162632
43Obstructive sleep apnea (HP:0002870)2.65912868
44Postural instability (HP:0002172)2.65786431
45Lower limb muscle weakness (HP:0007340)2.64653105
46Retinal dysplasia (HP:0007973)2.64604613
47Truncal ataxia (HP:0002078)2.62107624
48Abnormality of the lower motor neuron (HP:0002366)2.57100552
49Torticollis (HP:0000473)2.55053725
50Mutism (HP:0002300)2.54035953
51Abnormal eating behavior (HP:0100738)2.52189370
52Hemiparesis (HP:0001269)2.51943660
53Febrile seizures (HP:0002373)2.49956584
54Clonus (HP:0002169)2.49805121
55Tetraplegia (HP:0002445)2.46482439
56Gaze-evoked nystagmus (HP:0000640)2.45254274
57Papilledema (HP:0001085)2.42582769
58Sensory axonal neuropathy (HP:0003390)2.42003409
59Poor eye contact (HP:0000817)2.40288250
60Increased circulating renin level (HP:0000848)2.39135170
61Neuroendocrine neoplasm (HP:0100634)2.38698823
62Focal dystonia (HP:0004373)2.29946431
63Abnormal auditory evoked potentials (HP:0006958)2.25214494
64Progressive inability to walk (HP:0002505)2.24731291
65Alacrima (HP:0000522)2.24408126
66Apathy (HP:0000741)2.24340044
67Hyperventilation (HP:0002883)2.19532121
68Akinesia (HP:0002304)2.18408135
69Aplasia involving bones of the extremities (HP:0009825)2.18297040
70Aplasia involving bones of the upper limbs (HP:0009823)2.18297040
71Aplasia of the phalanges of the hand (HP:0009802)2.18297040
72Slow saccadic eye movements (HP:0000514)2.17724629
73Neuronal loss in central nervous system (HP:0002529)2.17579143
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15890067
75Abnormal social behavior (HP:0012433)2.15671667
76Impaired social interactions (HP:0000735)2.15671667
77Thickened helices (HP:0000391)2.15063164
78Generalized myoclonic seizures (HP:0002123)2.14839823
79Amyotrophic lateral sclerosis (HP:0007354)2.14569123
80Craniofacial dystonia (HP:0012179)2.14101706
81Diplopia (HP:0000651)2.12946322
82Abnormality of binocular vision (HP:0011514)2.12946322
83Excessive salivation (HP:0003781)2.08053668
84Drooling (HP:0002307)2.08053668
85Epileptiform EEG discharges (HP:0011182)2.07936561
86EEG with generalized epileptiform discharges (HP:0011198)2.07532311
87Diminished motivation (HP:0000745)2.05951471
88Hypsarrhythmia (HP:0002521)2.03833563
89Spastic tetraparesis (HP:0001285)2.03729901
90Fetal akinesia sequence (HP:0001989)2.03578636
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03428712
92Clumsiness (HP:0002312)2.01568133
93Impaired vibratory sensation (HP:0002495)2.01517608
94Incomplete penetrance (HP:0003829)2.01191420
95Impaired smooth pursuit (HP:0007772)2.00485293
96Spastic tetraplegia (HP:0002510)2.00412214
97Amblyopia (HP:0000646)2.00067030
98Rigidity (HP:0002063)1.99356992
99CNS hypomyelination (HP:0003429)1.96956664
100Bradykinesia (HP:0002067)1.95953018
101Agitation (HP:0000713)1.92842222
102Abnormality of saccadic eye movements (HP:0000570)1.92597837
103Split foot (HP:0001839)1.91538275
104Bowel incontinence (HP:0002607)1.90818055
105Morphological abnormality of the pyramidal tract (HP:0002062)1.90202849
106Blue irides (HP:0000635)1.89991338
107Insomnia (HP:0100785)1.89870182
108Psychosis (HP:0000709)1.88337348
109Turricephaly (HP:0000262)1.88238507
110Delusions (HP:0000746)1.87952129
111Choreoathetosis (HP:0001266)1.86757633
112Type II lissencephaly (HP:0007260)1.86083326
113Paraplegia (HP:0010550)1.85675203
114Hypoplasia of the corpus callosum (HP:0002079)1.85533684
115Rapidly progressive (HP:0003678)1.84526020
116Gait imbalance (HP:0002141)1.83368276
117Absent speech (HP:0001344)1.82916045
118Anteriorly placed anus (HP:0001545)1.80796995
119Hammertoe (HP:0001765)1.80765825
120Genetic anticipation (HP:0003743)1.80548884
121Stereotypic behavior (HP:0000733)1.79895390
122Failure to thrive in infancy (HP:0001531)1.79873235
123Gait ataxia (HP:0002066)1.77984344
124Specific learning disability (HP:0001328)1.77378486
125Poor speech (HP:0002465)1.77326290
126Abnormality of ocular smooth pursuit (HP:0000617)1.75634250
127Spastic paraplegia (HP:0001258)1.72044573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.81210369
2NTRK33.24428532
3MAP3K93.08723017
4STK393.02533096
5MARK12.69790539
6OXSR12.54622105
7PAK62.30440546
8NTRK12.27212616
9PRKD32.25124011
10KSR22.11558071
11UHMK12.07936507
12CDK191.98328707
13MAP3K41.92300937
14MINK11.91997635
15DAPK21.79975377
16NTRK21.74502318
17ARAF1.64292700
18PNCK1.63444533
19TNIK1.61793778
20CDK51.57367286
21PKN11.56090181
22WNK41.49177550
23MAPKAPK51.47100368
24MAP2K71.44837351
25TYRO31.44056171
26CAMK2B1.43993169
27BCR1.38010525
28PRPF4B1.33777810
29SGK4941.33084230
30SGK2231.33084230
31WNK11.32194395
32LATS21.31595767
33MAP3K21.30990785
34MAP3K131.24474406
35FGFR21.23250384
36CAMKK11.23151836
37CASK1.20778338
38EPHB11.20070062
39NEK61.12911169
40CSNK1G21.12315001
41PHKG11.10679979
42PHKG21.10679979
43KSR11.09432715
44LIMK11.07988367
45CDK141.06596867
46CAMK2A1.06346604
47MAPK131.06020314
48CAMK2D1.05572057
49PAK31.05477604
50RIPK11.05253271
51GRK51.03530733
52CDK151.03041726
53MAP2K41.02820353
54FES1.00995836
55CDK181.00932757
56MARK20.98816163
57PRKCH0.95660014
58CSNK1G30.95052757
59PLK20.92096048
60CDK11A0.91190766
61RIPK40.90918767
62CAMK2G0.90711317
63ROCK20.89336060
64CSNK1A1L0.88695480
65PRKCG0.87541599
66STK110.87158506
67SGK20.83280596
68ICK0.82476371
69FGR0.79619506
70PDPK10.77981261
71PINK10.74014810
72WNK30.73326529
73MET0.72337035
74MAP3K10.70944672
75MAP3K120.70916240
76BRSK10.70329417
77CAMKK20.68192495
78RET0.67698292
79PRKCE0.65306728
80SGK30.65188593
81CAMK10.65151694
82ALK0.63626290
83MAPK120.63036181
84CSNK1G10.61986127
85PDK10.60858554
86DYRK1A0.60355599
87FYN0.57743585
88CAMK40.57619898
89SIK20.56489458
90MAP3K110.55510359
91PRKD10.55409467
92SGK10.55271862
93STK380.53798552
94MAPK150.53674682
95PTK2B0.53081572
96DAPK30.52877177
97RAF10.52585791
98TESK10.52382060
99CAMK1G0.52199018
100TAOK10.51938675
101BMPR20.51509775
102DAPK10.50410002
103TESK20.49044397
104DYRK20.46079633
105MAPK100.45268979
106PRKCZ0.44821491
107MUSK0.43644707
108RPS6KA30.41780165
109PRKCQ0.40731265
110LMTK20.40652020
111ERBB20.39604499
112BRAF0.37648665
113PRKG10.37196188
114CSNK1E0.31929032
115PRKACA0.31777939
116RPS6KA20.30733712
117DYRK1B0.30616332
118CSNK1D0.30121452
119* PRKCA0.30050341
120MAPK80.28287224
121ROCK10.27407960

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.86137715
2Nicotine addiction_Homo sapiens_hsa050332.81177759
3GABAergic synapse_Homo sapiens_hsa047272.73476061
4Glutamatergic synapse_Homo sapiens_hsa047242.51209803
5Olfactory transduction_Homo sapiens_hsa047402.48744327
6Circadian entrainment_Homo sapiens_hsa047132.44839113
7Morphine addiction_Homo sapiens_hsa050322.39052155
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37991634
9Long-term potentiation_Homo sapiens_hsa047202.16310776
10Amphetamine addiction_Homo sapiens_hsa050312.15706162
11Nitrogen metabolism_Homo sapiens_hsa009102.12496373
12Dopaminergic synapse_Homo sapiens_hsa047282.02987271
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00381945
14Insulin secretion_Homo sapiens_hsa049111.95579570
15Salivary secretion_Homo sapiens_hsa049701.92997085
16Cocaine addiction_Homo sapiens_hsa050301.91665817
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82796274
18Cholinergic synapse_Homo sapiens_hsa047251.81881506
19Gastric acid secretion_Homo sapiens_hsa049711.81064094
20Serotonergic synapse_Homo sapiens_hsa047261.76697697
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71344230
22Long-term depression_Homo sapiens_hsa047301.69318449
23Renin secretion_Homo sapiens_hsa049241.51213437
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50404826
25Axon guidance_Homo sapiens_hsa043601.49508452
26Taste transduction_Homo sapiens_hsa047421.48688806
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48471344
28Collecting duct acid secretion_Homo sapiens_hsa049661.43389949
29Oxytocin signaling pathway_Homo sapiens_hsa049211.33970915
30Gap junction_Homo sapiens_hsa045401.31791554
31Vibrio cholerae infection_Homo sapiens_hsa051101.24360474
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23999193
33Calcium signaling pathway_Homo sapiens_hsa040201.23956317
34GnRH signaling pathway_Homo sapiens_hsa049121.21230713
35cAMP signaling pathway_Homo sapiens_hsa040241.16829231
36Ether lipid metabolism_Homo sapiens_hsa005651.14228979
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14137872
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11981432
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.04666112
40Fatty acid elongation_Homo sapiens_hsa000621.04582932
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03932864
42Type II diabetes mellitus_Homo sapiens_hsa049301.02433460
43Steroid biosynthesis_Homo sapiens_hsa001001.01066642
44Pancreatic secretion_Homo sapiens_hsa049720.99459235
45ErbB signaling pathway_Homo sapiens_hsa040120.98730880
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96796058
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96650576
48Dorso-ventral axis formation_Homo sapiens_hsa043200.96577649
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96081960
50Estrogen signaling pathway_Homo sapiens_hsa049150.95282748
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94931430
52Cardiac muscle contraction_Homo sapiens_hsa042600.94898226
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.94361037
54Melanogenesis_Homo sapiens_hsa049160.92147397
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84930560
56Renal cell carcinoma_Homo sapiens_hsa052110.82402725
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81103810
58Phototransduction_Homo sapiens_hsa047440.80834654
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.79798032
60Glioma_Homo sapiens_hsa052140.78168094
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78006811
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77465257
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76530392
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74535167
65Endocytosis_Homo sapiens_hsa041440.73980154
66Ras signaling pathway_Homo sapiens_hsa040140.73432407
67Thyroid hormone synthesis_Homo sapiens_hsa049180.72876260
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72657364
69Choline metabolism in cancer_Homo sapiens_hsa052310.65579451
70Alzheimers disease_Homo sapiens_hsa050100.65554897
71Arginine and proline metabolism_Homo sapiens_hsa003300.64507022
72Histidine metabolism_Homo sapiens_hsa003400.63205389
73Prion diseases_Homo sapiens_hsa050200.63082045
74Alcoholism_Homo sapiens_hsa050340.62360769
75MAPK signaling pathway_Homo sapiens_hsa040100.61356932
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59495495
77Butanoate metabolism_Homo sapiens_hsa006500.58277722
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57858380
79Ovarian steroidogenesis_Homo sapiens_hsa049130.57105457
80Oocyte meiosis_Homo sapiens_hsa041140.56433873
81Oxidative phosphorylation_Homo sapiens_hsa001900.56293917
82Type I diabetes mellitus_Homo sapiens_hsa049400.55358390
83Dilated cardiomyopathy_Homo sapiens_hsa054140.55147715
84Sphingolipid metabolism_Homo sapiens_hsa006000.55051296
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54594591
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51551408
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51188636
88Glucagon signaling pathway_Homo sapiens_hsa049220.50143752
89Tight junction_Homo sapiens_hsa045300.48882750
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.48860374
91beta-Alanine metabolism_Homo sapiens_hsa004100.48309007
92Rap1 signaling pathway_Homo sapiens_hsa040150.47655506
93Sulfur metabolism_Homo sapiens_hsa009200.47182815
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46708951
95Parkinsons disease_Homo sapiens_hsa050120.45798224
96VEGF signaling pathway_Homo sapiens_hsa043700.45736208
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45342756
98Inositol phosphate metabolism_Homo sapiens_hsa005620.43669887
99Hippo signaling pathway_Homo sapiens_hsa043900.43520281
100Circadian rhythm_Homo sapiens_hsa047100.43352374
101Bile secretion_Homo sapiens_hsa049760.43064572
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39704513
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38728389
104Vitamin B6 metabolism_Homo sapiens_hsa007500.37530493
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.36712613
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35856657
107Wnt signaling pathway_Homo sapiens_hsa043100.35837021
108Chemokine signaling pathway_Homo sapiens_hsa040620.35374883
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35340854
110Lysosome_Homo sapiens_hsa041420.33543858
111AMPK signaling pathway_Homo sapiens_hsa041520.31338227
112Regulation of autophagy_Homo sapiens_hsa041400.28103965
113Mineral absorption_Homo sapiens_hsa049780.26350849
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25467771
115Arginine biosynthesis_Homo sapiens_hsa002200.25202064
116Hedgehog signaling pathway_Homo sapiens_hsa043400.24891083

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »