APLP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)4.34828277
2COPI coating of Golgi vesicle (GO:0048205)4.29924310
3Golgi transport vesicle coating (GO:0048200)4.29924310
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.06043393
5cellular potassium ion homeostasis (GO:0030007)3.96299893
6synaptic vesicle maturation (GO:0016188)3.90982792
7barbed-end actin filament capping (GO:0051016)3.86105420
8protein retention in ER lumen (GO:0006621)3.84322795
9skin morphogenesis (GO:0043589)3.76622157
10sodium ion export (GO:0071436)3.73348973
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.72721559
12hemidesmosome assembly (GO:0031581)3.68166895
13apoptotic cell clearance (GO:0043277)3.66852809
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64495300
15locomotory exploration behavior (GO:0035641)3.46972696
16surfactant homeostasis (GO:0043129)3.43744794
17synaptic vesicle exocytosis (GO:0016079)3.32509638
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.28149595
19dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.27713063
20glutamate secretion (GO:0014047)3.26688692
21layer formation in cerebral cortex (GO:0021819)3.25745960
22epithelial cell-cell adhesion (GO:0090136)3.23799699
23pinocytosis (GO:0006907)3.22044901
24basement membrane organization (GO:0071711)3.21389081
25vocalization behavior (GO:0071625)3.21350790
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19339419
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13942963
28glycosphingolipid catabolic process (GO:0046479)3.12375446
29regulation of synaptic vesicle exocytosis (GO:2000300)3.10961367
30proline transport (GO:0015824)3.10770992
31cell-substrate junction assembly (GO:0007044)3.10587390
32semaphorin-plexin signaling pathway (GO:0071526)3.06009722
33stress fiber assembly (GO:0043149)3.03822466
34endodermal cell differentiation (GO:0035987)3.03480236
35oligosaccharide catabolic process (GO:0009313)3.01588830
36activation of protein kinase A activity (GO:0034199)3.01534594
37synaptic vesicle docking involved in exocytosis (GO:0016081)2.97542365
38potassium ion import (GO:0010107)2.92893781
39regulation of synapse structural plasticity (GO:0051823)2.91629583
40potassium ion homeostasis (GO:0055075)2.91509246
41cell communication by electrical coupling (GO:0010644)2.89769317
42neurotransmitter secretion (GO:0007269)2.88333690
43positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88134900
44substrate-dependent cell migration (GO:0006929)2.85598858
45regulation of early endosome to late endosome transport (GO:2000641)2.85531386
46gamma-aminobutyric acid transport (GO:0015812)2.81517028
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.80779878
48glycine transport (GO:0015816)2.80549745
49wound healing, spreading of epidermal cells (GO:0035313)2.78538969
50response to laminar fluid shear stress (GO:0034616)2.75921583
51positive regulation of extracellular matrix organization (GO:1903055)2.75193254
52alanine transport (GO:0032328)2.75185382
53glycolipid catabolic process (GO:0019377)2.74328056
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73879986
55positive regulation of receptor recycling (GO:0001921)2.73352547
56hyaluronan catabolic process (GO:0030214)2.72175698
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71346552
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.71243303
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70488647
60membrane protein ectodomain proteolysis (GO:0006509)2.70045442
61cellular sodium ion homeostasis (GO:0006883)2.69202916
62cell communication involved in cardiac conduction (GO:0086065)2.68432814
63adherens junction assembly (GO:0034333)2.67873578
64positive regulation of synapse maturation (GO:0090129)2.67185112
65neurotransmitter-gated ion channel clustering (GO:0072578)2.67052241
66hypotonic response (GO:0006971)2.64524572
67regulation of synaptic vesicle transport (GO:1902803)2.63101940
68cortical actin cytoskeleton organization (GO:0030866)2.61782442
69cerebellar granule cell differentiation (GO:0021707)2.61605155
70epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61188577
71protein hydroxylation (GO:0018126)2.59623088
72regulation of glutamate receptor signaling pathway (GO:1900449)2.59592434
73peptidyl-proline hydroxylation (GO:0019511)2.58459212
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56667207
75cellular response to thyroid hormone stimulus (GO:0097067)2.56448897
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56271157
77negative regulation of fibrinolysis (GO:0051918)2.55671210
78protein localization to synapse (GO:0035418)2.52756042
79vascular endothelial growth factor signaling pathway (GO:0038084)2.50980414
80dendrite morphogenesis (GO:0048813)2.50169160
81negative regulation of fatty acid transport (GO:2000192)2.50139461
82vesicle coating (GO:0006901)2.49404060
83desmosome organization (GO:0002934)2.48894671
84cerebellar Purkinje cell differentiation (GO:0021702)2.48556032
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.48521540
86response to pheromone (GO:0019236)2.47937703
87chemical homeostasis within a tissue (GO:0048875)2.47839831
88wound healing, spreading of cells (GO:0044319)2.47577986
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.46558753
90cell-substrate adherens junction assembly (GO:0007045)2.46338899
91focal adhesion assembly (GO:0048041)2.46338899
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46130829
93exploration behavior (GO:0035640)2.44167355
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.43569658
95neuron cell-cell adhesion (GO:0007158)2.43142899
96glomerular visceral epithelial cell development (GO:0072015)2.42809039
97iron ion import (GO:0097286)2.42521342
98neuronal action potential propagation (GO:0019227)2.41215465
99mannose metabolic process (GO:0006013)2.40814412
100mesodermal cell differentiation (GO:0048333)2.40450094
101ionotropic glutamate receptor signaling pathway (GO:0035235)2.39941270
102response to thyroid hormone (GO:0097066)2.39731351
103membrane repolarization (GO:0086009)2.39507155
104regulation of extracellular matrix disassembly (GO:0010715)2.39102757
105positive regulation of leukocyte degranulation (GO:0043302)2.38992156
106neuromuscular process controlling posture (GO:0050884)2.38015156
107peptide catabolic process (GO:0043171)2.37740821
108membrane raft organization (GO:0031579)2.37625390
109protein-lipid complex assembly (GO:0065005)2.37364399
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.37130596
111regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36949838
112regulation of clathrin-mediated endocytosis (GO:2000369)2.36931261
113positive regulation of osteoblast proliferation (GO:0033690)2.36601661
114cortical cytoskeleton organization (GO:0030865)2.36575192
115membrane hyperpolarization (GO:0060081)2.36207972
116regulation of neuronal synaptic plasticity (GO:0048168)2.36188448
117positive regulation of endothelial cell apoptotic process (GO:2000353)2.35677540
118planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35004760
119negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34939864
120establishment of nucleus localization (GO:0040023)2.33449036
121extracellular matrix disassembly (GO:0022617)2.32541610
122plasma lipoprotein particle assembly (GO:0034377)2.32442877
123glutamate receptor signaling pathway (GO:0007215)2.32083120
124neurotransmitter transport (GO:0006836)2.31410817
125endothelial cell chemotaxis (GO:0035767)2.31404477
126platelet degranulation (GO:0002576)2.31157719
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30684003
128keratan sulfate catabolic process (GO:0042340)2.30391597
129regulation of long-term neuronal synaptic plasticity (GO:0048169)2.30183268
130collagen metabolic process (GO:0032963)2.29604266
131positive regulation of nuclease activity (GO:0032075)2.29372778
132regulation of cholesterol homeostasis (GO:2000188)2.28808519
133synaptic transmission, glutamatergic (GO:0035249)2.28410044
134cell-cell junction maintenance (GO:0045217)2.28052378
135* cellular copper ion homeostasis (GO:0006878)2.27885167
136embryonic process involved in female pregnancy (GO:0060136)2.27786922
137endocytic recycling (GO:0032456)2.27547025
138* neuromuscular process controlling balance (GO:0050885)2.27334557
139membrane depolarization during action potential (GO:0086010)2.26891685
140regulation of membrane protein ectodomain proteolysis (GO:0051043)2.26146408
141negative regulation of protein localization to plasma membrane (GO:1903077)2.25731252
142neuron-neuron synaptic transmission (GO:0007270)2.25523564
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.25084457
144innervation (GO:0060384)2.24050440
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23430154
146regulation of voltage-gated calcium channel activity (GO:1901385)2.22954633
147branching involved in mammary gland duct morphogenesis (GO:0060444)2.22780314
148synaptic vesicle endocytosis (GO:0048488)2.22659928
149positive regulation of potassium ion transmembrane transport (GO:1901381)2.22560997
150positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.21932543
151axonal fasciculation (GO:0007413)2.21551276
152low-density lipoprotein particle clearance (GO:0034383)2.21409103
153prepulse inhibition (GO:0060134)2.21258932
154regulation of extracellular matrix organization (GO:1903053)2.20909814
155neuron recognition (GO:0008038)2.20902287
156ceramide catabolic process (GO:0046514)2.20898505
157positive regulation of phagocytosis (GO:0050766)2.20784402
158response to auditory stimulus (GO:0010996)2.20670027
159glomerular epithelial cell development (GO:0072310)2.20241110
160branching involved in salivary gland morphogenesis (GO:0060445)2.19611615
161embryo implantation (GO:0007566)2.19588740
162collagen catabolic process (GO:0030574)2.19442483
163phospholipid efflux (GO:0033700)2.18676262
164positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.18330648
165multicellular organismal macromolecule metabolic process (GO:0044259)2.18150489
166endoplasmic reticulum unfolded protein response (GO:0030968)2.17886350
167very-low-density lipoprotein particle assembly (GO:0034379)2.17734064
168endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.17342746
169regulation of cholesterol esterification (GO:0010872)2.16656303
170long term synaptic depression (GO:0060292)2.15701196
171dendritic spine morphogenesis (GO:0060997)2.15254327
172regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.14652915
173regulation of neurotransmitter levels (GO:0001505)2.13859433
174positive regulation of potassium ion transport (GO:0043268)2.13531420
175regulation of synaptic transmission, glutamatergic (GO:0051966)2.13095336
176positive regulation of macrophage cytokine production (GO:0060907)2.11595876
177protein localization to endosome (GO:0036010)2.10501041
178long-term memory (GO:0007616)2.10222031
179regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.09155851
180* mating behavior (GO:0007617)2.08011584
181regulation of excitatory postsynaptic membrane potential (GO:0060079)2.07991630
182gamma-aminobutyric acid signaling pathway (GO:0007214)2.07771004
183synapse assembly (GO:0007416)2.07749339
184vesicle transport along microtubule (GO:0047496)2.07732336
185regulation of heart rate by cardiac conduction (GO:0086091)2.07564045
186regulation of postsynaptic membrane potential (GO:0060078)2.04694626
187regulation of ARF protein signal transduction (GO:0032012)2.03780987
188long-term synaptic potentiation (GO:0060291)2.02900663
189protein targeting to plasma membrane (GO:0072661)2.02858754
190synapse organization (GO:0050808)2.02619295
191positive regulation of sodium ion transport (GO:0010765)2.02503517
192clathrin coat assembly (GO:0048268)2.02457223
193positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.01880313
194membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.00620841
195regulation of neurotransmitter secretion (GO:0046928)2.00484303
196regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.00469292
197negative regulation of synaptic transmission, glutamatergic (GO:0051967)1.98904911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37605775
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.70360748
3EZH2_22144423_ChIP-Seq_EOC_Human2.69256662
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68310814
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48882877
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34447350
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29334470
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29334470
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22880925
10DROSHA_22980978_ChIP-Seq_HELA_Human2.19670382
11GBX2_23144817_ChIP-Seq_PC3_Human2.18493861
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.17685419
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10936946
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05017778
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04942335
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.04278803
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02789963
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02201239
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01450809
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99751067
21* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95414654
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92222638
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92020808
24* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.88144393
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86745304
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.85898931
27* RACK7_27058665_Chip-Seq_MCF-7_Human1.81539953
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77797597
29* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77661980
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75793824
31* LXR_22292898_ChIP-Seq_THP-1_Human1.72093703
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.70748182
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70354894
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68913439
35* ZNF263_19887448_ChIP-Seq_K562_Human1.68530746
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.64030762
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.61087541
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.60995422
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60566875
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60005737
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59517007
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56000113
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54547906
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54547906
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54202104
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.54104258
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53972971
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53805411
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53607680
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53587898
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.53329267
52AR_21572438_ChIP-Seq_LNCaP_Human1.53062807
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53010855
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52659174
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50205294
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50070196
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50031730
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45738469
59* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45707684
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43221765
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42433302
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41953863
63REST_21632747_ChIP-Seq_MESCs_Mouse1.41775707
64CLOCK_20551151_ChIP-Seq_293T_Human1.38516126
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.37133032
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36916284
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36097954
68* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36040632
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34638713
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33684780
71* KDM2B_26808549_Chip-Seq_K562_Human1.33580516
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.33363832
73AHR_22903824_ChIP-Seq_MCF-7_Human1.33256089
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.32805448
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32554580
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31695182
77* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31080878
78TCF7_22412390_ChIP-Seq_EML_Mouse1.29713195
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.27841942
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.27841942
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27586193
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.26003258
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24150745
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.23617132
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22213475
86ATF3_27146783_Chip-Seq_COLON_Human1.22077409
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21498414
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21474447
89SOX2_20726797_ChIP-Seq_SW620_Human1.21211755
90* UBF1/2_26484160_Chip-Seq_HMECs_Human1.20144037
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.19947189
92* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18984383
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18792693
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.18552028
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16888911
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.15279513
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14889203
98SMAD4_21799915_ChIP-Seq_A2780_Human1.13626394
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13173715
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12981738
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12494970
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.11402118
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10719531
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.10640370
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09936023
106* KDM2B_26808549_Chip-Seq_DND41_Human1.08664205
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08346079
108IRF8_27001747_Chip-Seq_BMDM_Mouse1.07963843
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.07361742
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07014441
111* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06861435
112* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06446763
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06063885
114VDR_21846776_ChIP-Seq_THP-1_Human1.05591448
115BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05385729
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05133429
117AR_19668381_ChIP-Seq_PC3_Human1.04394417
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.03608980
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03181611
120ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02871001
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02143769
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02143769
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01768189
124LXR_22158963_ChIP-Seq_LIVER_Mouse1.01692041
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01656759
126* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01564689
127* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01353119
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01264548
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00841354
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00695208
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00686743
132TP53_22127205_ChIP-Seq_IMR90_Human1.00500016
133VDR_24763502_ChIP-Seq_THP-1_Human0.99730870
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99531457
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99153357
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98932468
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98796012
138RXR_22108803_ChIP-Seq_LS180_Human0.98247389
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.98240699
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98119040
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97831778
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96916508
143* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96361962
144TP53_16413492_ChIP-PET_HCT116_Human0.96289089
145ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94738277
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94028979
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93479616
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.93446844
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92930442
150STAT3_23295773_ChIP-Seq_U87_Human0.91809056
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.91196290
152AR_25329375_ChIP-Seq_VCAP_Human0.90883694
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.90433566
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90412473
155* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90358891
156BCAT_22108803_ChIP-Seq_LS180_Human0.89044379
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88438884
158TAF15_26573619_Chip-Seq_HEK293_Human0.87385967
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.87325126
160ZNF274_21170338_ChIP-Seq_K562_Hela0.86150228
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85779611
162* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85322975
163TP53_18474530_ChIP-ChIP_U2OS_Human0.84805389
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84600523
165GATA2_21666600_ChIP-Seq_HMVEC_Human0.84337942
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84031034
167* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83904847
168TP63_17297297_ChIP-ChIP_HaCaT_Human0.82462312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.11673054
2MP0005058_abnormal_lysosome_morphology3.79856646
3MP0003566_abnormal_cell_adhesion3.43965959
4MP0009840_abnormal_foam_cell3.09869839
5MP0002877_abnormal_melanocyte_morpholog2.73291803
6* MP0003635_abnormal_synaptic_transmissio2.70072728
7MP0009046_muscle_twitch2.45948301
8MP0004270_analgesia2.44558886
9MP0005257_abnormal_intraocular_pressure2.43982653
10MP0004858_abnormal_nervous_system2.34746099
11MP0003329_amyloid_beta_deposits2.25280167
12MP0003880_abnormal_central_pattern2.18148457
13MP0002064_seizures2.14139189
14MP0003091_abnormal_cell_migration2.13649452
15MP0004130_abnormal_muscle_cell2.11631622
16MP0009745_abnormal_behavioral_response2.03561740
17MP0003690_abnormal_glial_cell2.01120577
18MP0001849_ear_inflammation1.98084572
19MP0002063_abnormal_learning/memory/cond1.97026170
20MP0009780_abnormal_chondrocyte_physiolo1.96279153
21MP0000013_abnormal_adipose_tissue1.94628855
22MP0005409_darkened_coat_color1.88615391
23MP0005623_abnormal_meninges_morphology1.86133548
24MP0002272_abnormal_nervous_system1.85937606
25MP0002909_abnormal_adrenal_gland1.85504656
26MP0005670_abnormal_white_adipose1.85007442
27MP0003300_gastrointestinal_ulcer1.84204481
28MP0005023_abnormal_wound_healing1.82049663
29MP0006054_spinal_hemorrhage1.81912535
30MP0005451_abnormal_body_composition1.80481399
31MP0002734_abnormal_mechanical_nocicepti1.79337215
32MP0001968_abnormal_touch/_nociception1.77081666
33MP0005076_abnormal_cell_differentiation1.75775755
34MP0004885_abnormal_endolymph1.74332975
35MP0005167_abnormal_blood-brain_barrier1.72895661
36MP0004264_abnormal_extraembryonic_tissu1.71431251
37MP0001486_abnormal_startle_reflex1.71082299
38MP0003279_aneurysm1.70648353
39MP0004272_abnormal_basement_membrane1.70552664
40MP0001501_abnormal_sleep_pattern1.62678361
41MP0003453_abnormal_keratinocyte_physiol1.58394754
42MP0003828_pulmonary_edema1.56858210
43MP0010352_gastrointestinal_tract_polyps1.56362417
44MP0008569_lethality_at_weaning1.55985551
45MP0002090_abnormal_vision1.55472626
46MP0010234_abnormal_vibrissa_follicle1.54731075
47MP0002896_abnormal_bone_mineralization1.54384385
48MP0008260_abnormal_autophagy1.53911673
49MP0002572_abnormal_emotion/affect_behav1.53568429
50MP0003303_peritoneal_inflammation1.53300649
51MP0000751_myopathy1.52529764
52MP0002822_catalepsy1.52095800
53MP0001984_abnormal_olfaction1.50240867
54MP0005551_abnormal_eye_electrophysiolog1.49996405
55MP0002998_abnormal_bone_remodeling1.45027676
56MP0000858_altered_metastatic_potential1.41881277
57MP0001915_intracranial_hemorrhage1.41413692
58MP0004782_abnormal_surfactant_physiolog1.40173580
59MP0002735_abnormal_chemical_nociception1.39227855
60MP0000604_amyloidosis1.38654729
61MP0000537_abnormal_urethra_morphology1.38017225
62MP0002254_reproductive_system_inflammat1.37816315
63MP0000767_abnormal_smooth_muscle1.37756609
64MP0002733_abnormal_thermal_nociception1.37672362
65MP0005164_abnormal_response_to1.36869710
66MP0000003_abnormal_adipose_tissue1.36585294
67MP0003705_abnormal_hypodermis_morpholog1.36463539
68MP0003633_abnormal_nervous_system1.36440032
69MP0005666_abnormal_adipose_tissue1.34062167
70MP0005165_increased_susceptibility_to1.33106404
71MP0005423_abnormal_somatic_nervous1.32900031
72* MP0002067_abnormal_sensory_capabilities1.32604496
73MP0002736_abnormal_nociception_after1.31347830
74MP0010329_abnormal_lipoprotein_level1.28885294
75MP0005375_adipose_tissue_phenotype1.28420866
76MP0010368_abnormal_lymphatic_system1.27253375
77MP0008438_abnormal_cutaneous_collagen1.27248767
78MP0002837_dystrophic_cardiac_calcinosis1.26680629
79MP0001440_abnormal_grooming_behavior1.23974186
80MP0003941_abnormal_skin_development1.23564885
81MP0004215_abnormal_myocardial_fiber1.22811798
82MP0003045_fibrosis1.21159066
83MP0003634_abnormal_glial_cell1.20132335
84MP0001970_abnormal_pain_threshold1.19874655
85MP0003950_abnormal_plasma_membrane1.18721176
86MP0002184_abnormal_innervation1.18310962
87MP0002060_abnormal_skin_morphology1.17387008
88MP0004185_abnormal_adipocyte_glucose1.16421690
89MP0001502_abnormal_circadian_rhythm1.15834457
90MP0003631_nervous_system_phenotype1.15686483
91MP0004510_myositis1.15258155
92MP0006082_CNS_inflammation1.13956690
93MP0000920_abnormal_myelination1.13571352
94MP0002796_impaired_skin_barrier1.10776622
95MP0004924_abnormal_behavior1.10616471
96MP0005386_behavior/neurological_phenoty1.10616471
97MP0008004_abnormal_stomach_pH1.10069645
98MP0003632_abnormal_nervous_system1.09863772
99MP0000778_abnormal_nervous_system1.09381683
100MP0003075_altered_response_to1.08433401
101MP0001533_abnormal_skeleton_physiology1.08010589
102MP0005275_abnormal_skin_tensile1.06538347
103MP0001177_atelectasis1.05706193
104MP0000343_altered_response_to1.05609405
105MP0004036_abnormal_muscle_relaxation1.04936864
106MP0004811_abnormal_neuron_physiology1.04786205
107MP0004084_abnormal_cardiac_muscle1.02695098
108* MP0002882_abnormal_neuron_morphology1.01842941
109MP0003879_abnormal_hair_cell1.01280074
110MP0008961_abnormal_basal_metabolism1.00242223
111MP0005535_abnormal_body_temperature0.99187348
112MP0002229_neurodegeneration0.98914798
113MP0003436_decreased_susceptibility_to0.98226588
114MP0010030_abnormal_orbit_morphology0.97690164
115MP0000955_abnormal_spinal_cord0.96306647
116* MP0002066_abnormal_motor_capabilities/c0.95110095
117MP0006138_congestive_heart_failure0.94969351
118MP0002089_abnormal_postnatal_growth/wei0.94106979
119MP0004947_skin_inflammation0.93235892
120MP0001614_abnormal_blood_vessel0.93034939
121MP0002557_abnormal_social/conspecific_i0.92950335
122MP0009384_cardiac_valve_regurgitation0.92210120
123MP0005508_abnormal_skeleton_morphology0.92158921
124MP0005197_abnormal_uvea_morphology0.90463404
125MP0003448_altered_tumor_morphology0.90054537
126MP0001958_emphysema0.89946790
127MP0005464_abnormal_platelet_physiology0.88478948
128MP0002118_abnormal_lipid_homeostasis0.87487764
129MP0010678_abnormal_skin_adnexa0.87395166
130MP0003191_abnormal_cellular_cholesterol0.87389111
131MP0005620_abnormal_muscle_contractility0.87241174
132MP0000534_abnormal_ureter_morphology0.86380687
133MP0008775_abnormal_heart_ventricle0.86030514
134MP0004233_abnormal_muscle_weight0.85799208
135MP0002295_abnormal_pulmonary_circulatio0.85195297
136MP0003283_abnormal_digestive_organ0.85096676
137MP0002971_abnormal_brown_adipose0.84142696
138MP0004085_abnormal_heartbeat0.81968196
139MP0009278_abnormal_bone_marrow0.81060982
140MP0004883_abnormal_blood_vessel0.80250460
141MP0005390_skeleton_phenotype0.79649996
142MP0001542_abnormal_bone_strength0.79523403
143MP0005388_respiratory_system_phenotype0.79365052
144MP0002133_abnormal_respiratory_system0.79365052
145MP0001299_abnormal_eye_distance/0.77966670
146MP0010386_abnormal_urinary_bladder0.77893934
147MP0005621_abnormal_cell_physiology0.77017074
148MP0002139_abnormal_hepatobiliary_system0.76409783
149MP0003115_abnormal_respiratory_system0.76175088
150MP0008874_decreased_physiological_sensi0.75985563
151MP0002925_abnormal_cardiovascular_devel0.75626315
152MP0002972_abnormal_cardiac_muscle0.75399787
153MP0004145_abnormal_muscle_electrophysio0.75282335
154MP0003183_abnormal_peptide_metabolism0.73896242
155MP0002419_abnormal_innate_immunity0.73785206
156MP0004043_abnormal_pH_regulation0.73536119
157MP0008872_abnormal_physiological_respon0.73440170
158MP0001879_abnormal_lymphatic_vessel0.73003369
159MP0000762_abnormal_tongue_morphology0.72032289
160MP0001216_abnormal_epidermal_layer0.71741251
161MP0005501_abnormal_skin_physiology0.70697134
162MP0005595_abnormal_vascular_smooth0.69456242
163MP0004484_altered_response_of0.69080284
164MP0003172_abnormal_lysosome_physiology0.68704953
165MP0003795_abnormal_bone_structure0.68688432
166MP0000249_abnormal_blood_vessel0.67699369
167MP0010630_abnormal_cardiac_muscle0.66063316
168MP0005083_abnormal_biliary_tract0.65919262
169MP0000681_abnormal_thyroid_gland0.65479535
170MP0000467_abnormal_esophagus_morphology0.63578908

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.34086321
2Action tremor (HP:0002345)4.08623761
3Abnormality of liposaccharide metabolism (HP:0010968)4.06228610
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.06228610
5Abnormality of glycolipid metabolism (HP:0010969)4.06228610
6Premature rupture of membranes (HP:0001788)3.97708771
7Myokymia (HP:0002411)3.68856931
8Focal motor seizures (HP:0011153)3.43334968
9Focal seizures (HP:0007359)3.39938951
10Vertebral compression fractures (HP:0002953)3.31913836
11Supranuclear gaze palsy (HP:0000605)3.31156551
12Dysostosis multiplex (HP:0000943)3.26097332
13Neurofibrillary tangles (HP:0002185)3.23399323
14Amyloidosis (HP:0011034)3.18187895
15Cervical subluxation (HP:0003308)3.10465747
16Visual hallucinations (HP:0002367)3.06099071
17Cerebral inclusion bodies (HP:0100314)3.05634246
18Urinary glycosaminoglycan excretion (HP:0003541)2.90702707
19Mucopolysacchariduria (HP:0008155)2.90702707
20Progressive cerebellar ataxia (HP:0002073)2.84728536
21Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77509257
22Abnormality of polysaccharide metabolism (HP:0011012)2.77509257
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77509257
24Central scotoma (HP:0000603)2.75421767
25Myocardial infarction (HP:0001658)2.73862608
26Intention tremor (HP:0002080)2.73566053
27Vacuolated lymphocytes (HP:0001922)2.72300002
28Atonic seizures (HP:0010819)2.71686429
29Broad metatarsal (HP:0001783)2.69337208
30Flat acetabular roof (HP:0003180)2.68784027
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.66946996
32Osteolytic defects of the hand bones (HP:0009699)2.66946996
33Atrophic scars (HP:0001075)2.65413865
34Interstitial pulmonary disease (HP:0006530)2.64939556
35Loss of speech (HP:0002371)2.59439683
36Ankle clonus (HP:0011448)2.57537907
37Short nail (HP:0001799)2.57268670
38Hemiplegia (HP:0002301)2.52966523
39Abnormality of the lower motor neuron (HP:0002366)2.52447307
40Dysdiadochokinesis (HP:0002075)2.50328901
41Absence seizures (HP:0002121)2.47551920
42Generalized tonic-clonic seizures (HP:0002069)2.45653935
43Epileptic encephalopathy (HP:0200134)2.45423094
44Nuclear cataract (HP:0100018)2.43210064
45Dysmetric saccades (HP:0000641)2.40958060
46Insidious onset (HP:0003587)2.36440914
47Termporal pattern (HP:0011008)2.36440914
48Scanning speech (HP:0002168)2.36109180
49Torticollis (HP:0000473)2.35392937
50Depression (HP:0000716)2.33754147
51Postural instability (HP:0002172)2.33539422
52Ventricular fibrillation (HP:0001663)2.31791930
53Wormian bones (HP:0002645)2.31277947
54Hyperacusis (HP:0010780)2.28527724
55Febrile seizures (HP:0002373)2.27048897
56Abnormal eating behavior (HP:0100738)2.25858948
57Turricephaly (HP:0000262)2.22906346
58Pheochromocytoma (HP:0002666)2.21339487
59Mitral stenosis (HP:0001718)2.20808272
60Upper limb amyotrophy (HP:0009129)2.17656910
61Distal upper limb amyotrophy (HP:0007149)2.17656910
62Aortic dissection (HP:0002647)2.16936659
63Scotoma (HP:0000575)2.15315563
64Difficulty running (HP:0009046)2.15083834
65Aneurysm (HP:0002617)2.14019198
66Dysmetria (HP:0001310)2.13681057
67Dialeptic seizures (HP:0011146)2.12645490
68Hand muscle atrophy (HP:0009130)2.11010690
69Abnormality of macular pigmentation (HP:0008002)2.07771108
70Back pain (HP:0003418)2.07276179
71Broad face (HP:0000283)2.07178384
72Distal lower limb muscle weakness (HP:0009053)2.07173016
73Postural tremor (HP:0002174)2.06294386
74Impaired social interactions (HP:0000735)2.06189647
75Abnormal social behavior (HP:0012433)2.06189647
76Distal lower limb amyotrophy (HP:0008944)2.05816973
77Cerebral aneurysm (HP:0004944)2.05772737
78Bronchomalacia (HP:0002780)2.05768576
79Truncal ataxia (HP:0002078)2.04570420
80Abnormality of macrophages (HP:0004311)2.04391671
81Abnormality of the distal phalanges of the toes (HP:0010182)2.03829461
82Apathy (HP:0000741)2.03600660
83Abnormality of the acetabulum (HP:0003170)2.03253600
84Blue sclerae (HP:0000592)2.01735020
85Mutism (HP:0002300)2.01506927
86Aortic aneurysm (HP:0004942)2.01065001
87Axonal loss (HP:0003447)2.00944618
88Fragile skin (HP:0001030)2.00477914
89Urinary bladder sphincter dysfunction (HP:0002839)1.99336096
90Aplasia involving bones of the upper limbs (HP:0009823)1.96787015
91Aplasia of the phalanges of the hand (HP:0009802)1.96787015
92Aplasia involving bones of the extremities (HP:0009825)1.96787015
93Genetic anticipation (HP:0003743)1.96544393
94Abnormality of carpal bone ossification (HP:0006257)1.95744534
95Hemorrhage of the eye (HP:0011885)1.95073604
96Systemic lupus erythematosus (HP:0002725)1.94918192
97Gaze-evoked nystagmus (HP:0000640)1.94901985
98Lower limb muscle weakness (HP:0007340)1.94348729
99Increased variability in muscle fiber diameter (HP:0003557)1.93257019
100Increased cerebral lipofuscin (HP:0011813)1.92240105
101Anxiety (HP:0000739)1.91666578
102Diminished motivation (HP:0000745)1.91516889
103Ankle contracture (HP:0006466)1.91161555
104Shallow orbits (HP:0000586)1.90867578
105Skin nodule (HP:0200036)1.89052641
106Focal dystonia (HP:0004373)1.88886144
107Spinal rigidity (HP:0003306)1.88825938
108Hemiparesis (HP:0001269)1.88724930
109Cardiovascular calcification (HP:0011915)1.88182109
110Status epilepticus (HP:0002133)1.88158827
111Abnormality of the corticospinal tract (HP:0002492)1.87899678
112Poor eye contact (HP:0000817)1.87783876
113Craniofacial dystonia (HP:0012179)1.87575255
114Neuronal loss in central nervous system (HP:0002529)1.87370062
115Rapidly progressive (HP:0003678)1.86269248
116Coxa vara (HP:0002812)1.85430879
117Oligomenorrhea (HP:0000876)1.85182730
118Bone pain (HP:0002653)1.85065956
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.84190138
120Congenital stationary night blindness (HP:0007642)1.84035708
121Abnormal ossification of hand bones (HP:0005921)1.83924928
122Prolonged QT interval (HP:0001657)1.83269747
123Pigmentary retinal degeneration (HP:0001146)1.82308437
124Ulnar bowing (HP:0003031)1.80734767
125Syncope (HP:0001279)1.80355777
126Hypercortisolism (HP:0001578)1.80281553
127Bladder diverticulum (HP:0000015)1.79786393
128Hammertoe (HP:0001765)1.79761401
129Vascular calcification (HP:0004934)1.79654603
130Urinary urgency (HP:0000012)1.79610834
131Abnormality of the common coagulation pathway (HP:0010990)1.79294861
132Upper motor neuron abnormality (HP:0002127)1.78564583
133Spondylolisthesis (HP:0003302)1.78245229
134Exercise-induced myalgia (HP:0003738)1.77339029
135Resting tremor (HP:0002322)1.77328953
136Cerebral hemorrhage (HP:0001342)1.77209393
137Right ventricular cardiomyopathy (HP:0011663)1.77166834
138Increased connective tissue (HP:0009025)1.76832128
139Spastic gait (HP:0002064)1.76684347
140Hypoventilation (HP:0002791)1.76158222
141Abnormality of complement system (HP:0005339)1.75425688
142Lymphangioma (HP:0100764)1.75113185
143Natal tooth (HP:0000695)1.75069646
144Onion bulb formation (HP:0003383)1.74901953
145Achilles tendon contracture (HP:0001771)1.74622847
146Acanthosis nigricans (HP:0000956)1.74320733
147Esophageal varix (HP:0002040)1.74237374
148Ovoid vertebral bodies (HP:0003300)1.74037965
149Hyporeflexia of lower limbs (HP:0002600)1.73227654
150Mitral valve prolapse (HP:0001634)1.72588985
151Ankyloglossia (HP:0010296)1.72384938
152Mitral regurgitation (HP:0001653)1.72266191
153Neuroendocrine neoplasm (HP:0100634)1.72240245
154Tetraparesis (HP:0002273)1.71070613
155Synostosis involving the elbow (HP:0003938)1.70850376
156Humeroradial synostosis (HP:0003041)1.70850376
157Deep venous thrombosis (HP:0002625)1.70816202
158Dilatation of the ascending aorta (HP:0005111)1.70455296
159Asymmetric septal hypertrophy (HP:0001670)1.70335489
160Advanced eruption of teeth (HP:0006288)1.69568746
161Pathologic fracture (HP:0002756)1.69399080
162Abnormality of the Achilles tendon (HP:0005109)1.68734687
163Joint stiffness (HP:0001387)1.68142680
164Insomnia (HP:0100785)1.68071483
165Enlarged penis (HP:0000040)1.67358835
166Subcapsular cataract (HP:0000523)1.67169299
167Buphthalmos (HP:0000557)1.67088454
168Megalencephaly (HP:0001355)1.66238854
169Arnold-Chiari malformation (HP:0002308)1.66155115
170Disproportionate tall stature (HP:0001519)1.65878209
171Impaired vibration sensation in the lower limbs (HP:0002166)1.65779927
172Thin bony cortex (HP:0002753)1.65639379
173Abnormality of dentin (HP:0010299)1.65385264
174Lower limb amyotrophy (HP:0007210)1.63533191
175Xanthomatosis (HP:0000991)1.63200541
176Neonatal short-limb short stature (HP:0008921)1.61084269
177Abnormality of binocular vision (HP:0011514)1.60981726
178Diplopia (HP:0000651)1.60981726
179Macroorchidism (HP:0000053)1.60880270
180Arterial tortuosity (HP:0005116)1.60653598
181Sudden death (HP:0001699)1.60554699
182Vascular tortuosity (HP:0004948)1.59670705
183Hyperextensible skin (HP:0000974)1.59629995
184Abnormality of the lumbar spine (HP:0100712)1.59444424
185Clonus (HP:0002169)1.58799545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.45617028
2RIPK12.88733293
3MST1R2.77172636
4MAP3K92.57401297
5ERN12.53803200
6DAPK22.33149565
7IRAK32.26079993
8NTRK32.23738507
9LMTK22.23506948
10PAK42.23138671
11PAK62.12724495
12MAP3K42.12451631
13NTRK12.07409934
14EPHA41.98402344
15TRIB31.95323803
16TGFBR21.94597837
17KSR21.91238395
18MET1.86381026
19MINK11.85039695
20CDK121.82271056
21TESK11.78653979
22CAMK1G1.77382204
23MARK11.75751716
24PHKG11.71687443
25PHKG21.71687443
26CAMK1D1.69218226
27MAP2K41.61217364
28PRKD31.60947302
29CAMKK11.57093397
30FER1.55480176
31FGFR41.50649045
32STK381.45979781
33MOS1.45872662
34ERBB41.41669965
35NTRK21.36862204
36MAP3K21.35934566
37MAP3K31.35437654
38LATS11.32863814
39SMG11.31760113
40CAMKK21.30658851
41SIK11.30177593
42RET1.30004338
43TIE11.29917242
44FGFR21.25720841
45PAK31.21995463
46MAP2K31.19420027
47LATS21.17690943
48SGK4941.17153128
49SGK2231.17153128
50TYRO31.16148558
51EPHB11.15744247
52NEK91.15626378
53WNK11.13962776
54STK391.13666161
55MAP2K71.13427121
56OXSR11.11598161
57CDK51.08971333
58PDGFRA1.07326242
59LIMK11.06847882
60PRKCH1.04856982
61EEF2K1.02367447
62DDR21.01045890
63EPHB20.94938948
64MTOR0.94663487
65GRK50.93800737
66MAP3K60.93169424
67NEK10.93041984
68SGK30.92431453
69WNK40.91829129
70TESK20.88232948
71PAK20.87932544
72PTK2B0.86771221
73PTK60.86190374
74ZAP700.84565624
75RPS6KA20.83044259
76PINK10.82834299
77SCYL20.81949725
78KSR10.81484496
79MAP2K10.81348605
80PTK20.80976141
81PKN20.79642908
82MAP3K140.79454116
83ARAF0.78868134
84PRKG20.77454145
85SGK20.77139716
86PDK30.75631386
87PDK40.75631386
88PLK20.73472440
89PDPK10.72477146
90BMX0.70812241
91TTN0.69436788
92FGR0.69242414
93MYLK0.68754094
94PRPF4B0.68621847
95ICK0.66658329
96CDK60.64728505
97TAOK20.64449803
98PRKCE0.64012445
99PRKCG0.63940384
100NME20.63916973
101PRKD20.63846863
102CSK0.63619302
103ABL20.63441414
104PDK20.63360581
105ROCK20.63300360
106CAMK2A0.62745591
107CAMK2G0.61863384
108DMPK0.61745402
109CAMK2D0.61489866
110CAMK10.59620029
111PRKD10.58459404
112STK110.58349809
113MAP3K70.57617918
114TBK10.57066671
115ROCK10.55976697
116STK100.55821680
117PDK10.55387876
118PRKCZ0.55149894
119TRPM70.54686603
120TYK20.54605374
121CSNK1G20.54190911
122CAMK2B0.53957634
123CDK140.53386904
124MAP3K10.52866131
125SGK10.52279092
126ALK0.52253710
127FGFR10.51764023
128MAP3K130.50659278
129CDC42BPA0.50333277
130MAP3K80.50258835
131PDGFRB0.49230504
132CAMK40.48650825
133YES10.48273964
134MARK20.48024733
135TAOK10.47972901
136FYN0.47801884
137SRC0.47646226
138PRKAA10.46935685
139BCR0.46698338
140ERBB20.46335710
141SIK20.45198275
142LRRK20.43543267
143MAP3K120.43352838
144FGFR30.42555992
145MATK0.42139509
146PIM20.41640640
147JAK10.38572069
148FLT30.38492788
149MAPK70.35652588
150NEK60.33974471
151MAP3K110.33849271
152GSK3A0.32269520
153RPS6KC10.29006200
154RPS6KL10.29006200
155CDK150.28789599

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.53645621
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.16442904
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.96013723
4Synaptic vesicle cycle_Homo sapiens_hsa047212.34200293
5Nitrogen metabolism_Homo sapiens_hsa009102.27348507
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01958467
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99806126
8GABAergic synapse_Homo sapiens_hsa047271.95228014
9Nicotine addiction_Homo sapiens_hsa050331.94237707
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82528202
11Olfactory transduction_Homo sapiens_hsa047401.74600479
12Circadian entrainment_Homo sapiens_hsa047131.69098881
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66582323
14Complement and coagulation cascades_Homo sapiens_hsa046101.63007929
15Morphine addiction_Homo sapiens_hsa050321.59119691
16Salivary secretion_Homo sapiens_hsa049701.57005953
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55507183
18Adherens junction_Homo sapiens_hsa045201.54995614
19Glutamatergic synapse_Homo sapiens_hsa047241.51164836
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.49934008
21Gastric acid secretion_Homo sapiens_hsa049711.46139274
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46137915
23Fatty acid biosynthesis_Homo sapiens_hsa000611.42787828
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42378953
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.38920452
26Renin secretion_Homo sapiens_hsa049241.38913182
27Bladder cancer_Homo sapiens_hsa052191.36577908
28Galactose metabolism_Homo sapiens_hsa000521.33841610
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30213984
30Long-term potentiation_Homo sapiens_hsa047201.26838641
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24947347
32PPAR signaling pathway_Homo sapiens_hsa033201.24207229
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24091768
34Bile secretion_Homo sapiens_hsa049761.23807468
35Cholinergic synapse_Homo sapiens_hsa047251.23284804
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22074126
37Dopaminergic synapse_Homo sapiens_hsa047281.21959704
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21341525
39Insulin secretion_Homo sapiens_hsa049111.20935543
40Chronic myeloid leukemia_Homo sapiens_hsa052201.20437973
41Fatty acid metabolism_Homo sapiens_hsa012121.17232056
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13432607
43Sphingolipid metabolism_Homo sapiens_hsa006001.08767046
44Amphetamine addiction_Homo sapiens_hsa050311.08087215
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07203005
46Pancreatic cancer_Homo sapiens_hsa052121.05650573
47Salmonella infection_Homo sapiens_hsa051321.05118415
48Oxytocin signaling pathway_Homo sapiens_hsa049211.04475991
49Butanoate metabolism_Homo sapiens_hsa006501.04121562
50Taste transduction_Homo sapiens_hsa047421.02547912
51Small cell lung cancer_Homo sapiens_hsa052221.01661486
52Collecting duct acid secretion_Homo sapiens_hsa049661.01380481
53Pertussis_Homo sapiens_hsa051331.00737598
54Thyroid cancer_Homo sapiens_hsa052161.00286907
55Propanoate metabolism_Homo sapiens_hsa006400.99800499
56Phagosome_Homo sapiens_hsa041450.99633535
57Arginine biosynthesis_Homo sapiens_hsa002200.99209439
58Notch signaling pathway_Homo sapiens_hsa043300.98493305
59Fatty acid degradation_Homo sapiens_hsa000710.96919387
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95562896
61VEGF signaling pathway_Homo sapiens_hsa043700.95502930
62cAMP signaling pathway_Homo sapiens_hsa040240.95444162
63Dilated cardiomyopathy_Homo sapiens_hsa054140.95366221
64Type II diabetes mellitus_Homo sapiens_hsa049300.95346777
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94988455
66Long-term depression_Homo sapiens_hsa047300.93872294
67Osteoclast differentiation_Homo sapiens_hsa043800.90981034
68Endometrial cancer_Homo sapiens_hsa052130.89521671
69Calcium signaling pathway_Homo sapiens_hsa040200.88910301
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88723063
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.87757022
72GnRH signaling pathway_Homo sapiens_hsa049120.87603993
73Gap junction_Homo sapiens_hsa045400.87462421
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86494395
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86319706
76Shigellosis_Homo sapiens_hsa051310.86260754
77Estrogen signaling pathway_Homo sapiens_hsa049150.86047987
78Malaria_Homo sapiens_hsa051440.85691046
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85133436
80Axon guidance_Homo sapiens_hsa043600.84729959
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84428379
82Pentose phosphate pathway_Homo sapiens_hsa000300.84306045
83N-Glycan biosynthesis_Homo sapiens_hsa005100.84203278
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83767974
85Cocaine addiction_Homo sapiens_hsa050300.83321284
86Phototransduction_Homo sapiens_hsa047440.82425170
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81280192
88Serotonergic synapse_Homo sapiens_hsa047260.79908072
89Thyroid hormone synthesis_Homo sapiens_hsa049180.79763878
90Glycerolipid metabolism_Homo sapiens_hsa005610.79153755
91Dorso-ventral axis formation_Homo sapiens_hsa043200.76794948
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76578897
93HIF-1 signaling pathway_Homo sapiens_hsa040660.76505572
94Hepatitis C_Homo sapiens_hsa051600.76385307
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.75908387
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.75812459
97TNF signaling pathway_Homo sapiens_hsa046680.75187061
98Non-small cell lung cancer_Homo sapiens_hsa052230.74714383
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74172920
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.74124526
101Fructose and mannose metabolism_Homo sapiens_hsa000510.73714287
102Toxoplasmosis_Homo sapiens_hsa051450.72178675
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71655153
104Acute myeloid leukemia_Homo sapiens_hsa052210.70852624
105ECM-receptor interaction_Homo sapiens_hsa045120.70791417
106Melanogenesis_Homo sapiens_hsa049160.69266958
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.69261764
108Glioma_Homo sapiens_hsa052140.68958684
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67946563
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67344029
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67304769
112MicroRNAs in cancer_Homo sapiens_hsa052060.67264687
113Protein digestion and absorption_Homo sapiens_hsa049740.66322090
114Pyruvate metabolism_Homo sapiens_hsa006200.66318470
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63991193
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63465086
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63004005
118Pancreatic secretion_Homo sapiens_hsa049720.62665272
119Vibrio cholerae infection_Homo sapiens_hsa051100.60864283
120Renin-angiotensin system_Homo sapiens_hsa046140.60407377
121Tuberculosis_Homo sapiens_hsa051520.60108285
122AMPK signaling pathway_Homo sapiens_hsa041520.59528645
123Focal adhesion_Homo sapiens_hsa045100.59376125
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59275282
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59256957
126ErbB signaling pathway_Homo sapiens_hsa040120.58032042
127Choline metabolism in cancer_Homo sapiens_hsa052310.57484195
128Prostate cancer_Homo sapiens_hsa052150.56821436
129Amoebiasis_Homo sapiens_hsa051460.56362968
130Hippo signaling pathway_Homo sapiens_hsa043900.56300944
131Ovarian steroidogenesis_Homo sapiens_hsa049130.56141640
132Insulin signaling pathway_Homo sapiens_hsa049100.55774226
133Apoptosis_Homo sapiens_hsa042100.55263299
134Pathways in cancer_Homo sapiens_hsa052000.55098631
135Glucagon signaling pathway_Homo sapiens_hsa049220.54540341
136Insulin resistance_Homo sapiens_hsa049310.53997618
137Tight junction_Homo sapiens_hsa045300.53897457
138Lysosome_Homo sapiens_hsa041420.53710827
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53079095
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52871205
141Platelet activation_Homo sapiens_hsa046110.52414785
142Mineral absorption_Homo sapiens_hsa049780.50632087
143Rap1 signaling pathway_Homo sapiens_hsa040150.50503254
144Prion diseases_Homo sapiens_hsa050200.50314717
145Staphylococcus aureus infection_Homo sapiens_hsa051500.49991698
146Prolactin signaling pathway_Homo sapiens_hsa049170.49512040
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49284374
148mTOR signaling pathway_Homo sapiens_hsa041500.48793932
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48270132
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48207208
151Endocytosis_Homo sapiens_hsa041440.47505851
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.46759565
153Proteoglycans in cancer_Homo sapiens_hsa052050.46512619
154Cardiac muscle contraction_Homo sapiens_hsa042600.46483725
155Inositol phosphate metabolism_Homo sapiens_hsa005620.45794568
156beta-Alanine metabolism_Homo sapiens_hsa004100.45720607
157Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45626952
158Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44657483
159Renal cell carcinoma_Homo sapiens_hsa052110.44608268
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.43994385

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