APMAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1valine metabolic process (GO:0006573)5.91697250
2regulation of sequestering of triglyceride (GO:0010889)5.59730941
3low-density lipoprotein particle clearance (GO:0034383)5.18331067
4alpha-linolenic acid metabolic process (GO:0036109)4.98952606
5triglyceride catabolic process (GO:0019433)4.88509630
6fatty acid beta-oxidation (GO:0006635)4.86972579
7biotin metabolic process (GO:0006768)4.72892787
8branched-chain amino acid catabolic process (GO:0009083)4.71450666
9neutral lipid catabolic process (GO:0046461)4.65856811
10acylglycerol catabolic process (GO:0046464)4.65856811
11lysine catabolic process (GO:0006554)4.64536219
12lysine metabolic process (GO:0006553)4.64536219
13branched-chain amino acid metabolic process (GO:0009081)4.62757380
14fatty acid oxidation (GO:0019395)4.56935823
15NADH metabolic process (GO:0006734)4.51818349
16lipid oxidation (GO:0034440)4.48672460
17fatty acid catabolic process (GO:0009062)4.40265705
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.30971014
19brown fat cell differentiation (GO:0050873)4.19804551
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.18139828
21L-phenylalanine catabolic process (GO:0006559)4.18139828
222-oxoglutarate metabolic process (GO:0006103)4.16848797
23tricarboxylic acid metabolic process (GO:0072350)4.13308762
24L-phenylalanine metabolic process (GO:0006558)4.10395089
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.10395089
26short-chain fatty acid metabolic process (GO:0046459)4.09414692
27sulfur amino acid catabolic process (GO:0000098)4.05037347
28positive regulation of fatty acid oxidation (GO:0046321)3.99457813
29acetyl-CoA metabolic process (GO:0006084)3.95774046
30positive regulation of fatty acid beta-oxidation (GO:0032000)3.89449530
31thioester biosynthetic process (GO:0035384)3.88649034
32acyl-CoA biosynthetic process (GO:0071616)3.88649034
33succinate metabolic process (GO:0006105)3.88130728
34monocarboxylic acid catabolic process (GO:0072329)3.87034938
35tricarboxylic acid cycle (GO:0006099)3.86926984
36fatty acid transmembrane transport (GO:1902001)3.84879146
37triglyceride biosynthetic process (GO:0019432)3.79889606
38regulation of triglyceride catabolic process (GO:0010896)3.77696121
39white fat cell differentiation (GO:0050872)3.77428214
40cysteine metabolic process (GO:0006534)3.72231471
41regulation of cholesterol storage (GO:0010885)3.72146205
42fatty-acyl-CoA biosynthetic process (GO:0046949)3.72138682
43oxaloacetate metabolic process (GO:0006107)3.71731803
44negative regulation of fibrinolysis (GO:0051918)3.68160010
45neutral lipid biosynthetic process (GO:0046460)3.67990919
46acylglycerol biosynthetic process (GO:0046463)3.67990919
47negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.67391514
48triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.64079316
49amino-acid betaine metabolic process (GO:0006577)3.63000713
50carnitine metabolic process (GO:0009437)3.62810230
51fatty-acyl-CoA metabolic process (GO:0035337)3.59303983
52regulation of fatty acid oxidation (GO:0046320)3.54041780
53triglyceride homeostasis (GO:0070328)3.52361002
54acylglycerol homeostasis (GO:0055090)3.52361002
55complement activation, alternative pathway (GO:0006957)3.51935142
56long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.51344245
57plasma lipoprotein particle clearance (GO:0034381)3.49564873
58negative regulation of cell killing (GO:0031342)3.48700828
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48700828
60carnitine shuttle (GO:0006853)3.47466985
61triglyceride metabolic process (GO:0006641)3.46996608
62glycerolipid catabolic process (GO:0046503)3.46170042
63regulation of fatty acid beta-oxidation (GO:0031998)3.39320355
64positive regulation of lipid catabolic process (GO:0050996)3.37931398
65cellular ketone body metabolic process (GO:0046950)3.36740485
66lipid particle organization (GO:0034389)3.35380671
67aspartate family amino acid catabolic process (GO:0009068)3.33693446
68COPI coating of Golgi vesicle (GO:0048205)3.33068767
69Golgi transport vesicle coating (GO:0048200)3.33068767
70long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.33066287
71aromatic amino acid family catabolic process (GO:0009074)3.32430948
72glyoxylate metabolic process (GO:0046487)3.30691569
73acylglycerol metabolic process (GO:0006639)3.29606268
74neutral lipid metabolic process (GO:0006638)3.26380307
75regulation of fibrinolysis (GO:0051917)3.25930227
76acyl-CoA metabolic process (GO:0006637)3.25709368
77thioester metabolic process (GO:0035383)3.25709368
78positive regulation of fatty acid metabolic process (GO:0045923)3.23118355
79carboxylic acid catabolic process (GO:0046395)3.18633423
80organic acid catabolic process (GO:0016054)3.18633423
81regulation of cholesterol esterification (GO:0010872)3.17349927
82regulation of protein activation cascade (GO:2000257)3.16810650
83fatty acid homeostasis (GO:0055089)3.16115508
84amino-acid betaine transport (GO:0015838)3.12761631
85carnitine transport (GO:0015879)3.12761631
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10733023
87ethanol oxidation (GO:0006069)3.08591517
88protein localization to endosome (GO:0036010)3.06254606
89regulation of complement activation (GO:0030449)3.06143999
90protein retention in ER lumen (GO:0006621)3.03936904
91peptidyl-glutamic acid carboxylation (GO:0017187)3.03897823
92protein carboxylation (GO:0018214)3.03897823
93regulation of triglyceride metabolic process (GO:0090207)3.03104363
94pentose-phosphate shunt (GO:0006098)3.03037327
95carnitine transmembrane transport (GO:1902603)3.02159925
96NADPH regeneration (GO:0006740)3.00173517
97cellular amino acid catabolic process (GO:0009063)2.99500445
98glucose 6-phosphate metabolic process (GO:0051156)2.98393094
99positive regulation of triglyceride metabolic process (GO:0090208)2.96997660
100regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96306383
101drug transmembrane transport (GO:0006855)2.95689089
102coenzyme A metabolic process (GO:0015936)2.95554450
103bile acid biosynthetic process (GO:0006699)2.95501978
104regulation of triglyceride biosynthetic process (GO:0010866)2.94884326
105amino sugar catabolic process (GO:0046348)2.93151065
106quaternary ammonium group transport (GO:0015697)2.92769949
107alpha-amino acid catabolic process (GO:1901606)2.90392861
108cellular lipid catabolic process (GO:0044242)2.89989096
109regulation of natural killer cell mediated immunity (GO:0002715)2.88966320
110regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88966320
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88109084
112ketone body metabolic process (GO:1902224)2.87683597
113positive regulation of triglyceride lipase activity (GO:0061365)2.87424203
114positive regulation of lipoprotein lipase activity (GO:0051006)2.87424203
115detection of molecule of bacterial origin (GO:0032490)2.87324074
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87051303
117negative regulation of lipase activity (GO:0060192)2.86955448
118homocysteine metabolic process (GO:0050667)2.86412536
119regulation of cholesterol biosynthetic process (GO:0045540)2.84193494
120glucose catabolic process (GO:0006007)2.83799189
121response to peptidoglycan (GO:0032494)2.81706892
122coenzyme A biosynthetic process (GO:0015937)2.81483104
123detection of other organism (GO:0098543)2.80359410
124lipid storage (GO:0019915)2.77572956
125regulation of acyl-CoA biosynthetic process (GO:0050812)2.76534330
126regulation of cholesterol metabolic process (GO:0090181)2.75480849
127neutrophil activation involved in immune response (GO:0002283)2.75334439
128acute-phase response (GO:0006953)2.75302443
129linoleic acid metabolic process (GO:0043651)2.75226959
130positive regulation of cholesterol efflux (GO:0010875)2.73176749
131detection of external biotic stimulus (GO:0098581)2.73104589
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69705651
133regulation of superoxide anion generation (GO:0032928)2.66241052
134L-serine transport (GO:0015825)2.65637507
135positive regulation of hemostasis (GO:1900048)2.64936623
136positive regulation of blood coagulation (GO:0030194)2.64936623
137negative regulation of interleukin-12 production (GO:0032695)2.63207603
138phospholipid efflux (GO:0033700)2.61855861
139regulation of leukocyte degranulation (GO:0043300)2.61598206
140positive regulation of coagulation (GO:0050820)2.60697955
141antigen processing and presentation of endogenous antigen (GO:0019883)2.59855140
142leukocyte migration involved in inflammatory response (GO:0002523)2.59776922
143detection of bacterium (GO:0016045)2.59662545
144very-low-density lipoprotein particle assembly (GO:0034379)2.59237993
145signal complex assembly (GO:0007172)2.59230355
146positive regulation of natural killer cell mediated immunity (GO:0002717)2.58963441
147killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.58096089
148disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.58096089
149cholesterol efflux (GO:0033344)2.53599798
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51727256
151fibrinolysis (GO:0042730)2.51701846
152regulation of mast cell degranulation (GO:0043304)2.50463388
153urea metabolic process (GO:0019627)2.50175626
154low-density lipoprotein particle remodeling (GO:0034374)2.49525576
155protein maturation by protein folding (GO:0022417)2.49265682
156apoptotic cell clearance (GO:0043277)2.48554528
157regulation of apoptotic cell clearance (GO:2000425)2.48009333
158serine transport (GO:0032329)2.47633087
159regulation of macrophage chemotaxis (GO:0010758)2.47348418
160regulation of activation of Janus kinase activity (GO:0010533)2.47348112
161positive regulation of cellular amide metabolic process (GO:0034250)2.46924644
162positive regulation of monocyte chemotaxis (GO:0090026)2.46488091
163regulation of plasminogen activation (GO:0010755)2.46203452
164nitrogen cycle metabolic process (GO:0071941)2.45891588
165positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.45792402
166negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.44626223
167urea cycle (GO:0000050)2.44152477
168positive regulation of phagocytosis (GO:0050766)2.44069389
169amyloid precursor protein catabolic process (GO:0042987)2.43801453
170positive regulation of fatty acid biosynthetic process (GO:0045723)2.42672438
171positive regulation of sterol transport (GO:0032373)2.42452023
172positive regulation of cholesterol transport (GO:0032376)2.42452023
173positive regulation of gamma-delta T cell activation (GO:0046645)2.42161429
174pentose metabolic process (GO:0019321)2.42081961
175pinocytosis (GO:0006907)2.41332321
176regulation of amyloid precursor protein catabolic process (GO:1902991)2.41013025
177plasma lipoprotein particle assembly (GO:0034377)2.40329904
178detection of biotic stimulus (GO:0009595)2.40260568
179positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.38610248
180granulocyte activation (GO:0036230)2.38296926
181regulation of phagocytosis (GO:0050764)2.35850361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.88942993
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.13487027
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.94052497
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.34133118
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.18827977
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.87256105
7CLOCK_20551151_ChIP-Seq_293T_Human3.52633139
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.31971251
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.14652488
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69943947
11GATA1_22025678_ChIP-Seq_K562_Human2.60346244
12* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.58653897
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.54562302
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.43774899
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.11247428
16* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05821632
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.05607553
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.6096197
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92345510
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90129867
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.89387831
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87558101
23ZNF263_19887448_ChIP-Seq_K562_Human1.81929556
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80499034
25VDR_21846776_ChIP-Seq_THP-1_Human1.65155645
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64625656
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62681094
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58918318
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.57091245
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.50897358
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50149271
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49860508
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.49039407
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46161434
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45489637
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44605354
37CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43626910
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42749607
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.41462843
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40797982
41VDR_24763502_ChIP-Seq_THP-1_Human1.40646827
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38982047
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37707225
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35361756
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34540127
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.33875985
47PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33071863
48SPI1_23547873_ChIP-Seq_NB4_Human1.32875956
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30675299
50PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30423991
51SPI1_23127762_ChIP-Seq_K562_Human1.26790046
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.26736076
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26446931
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24839929
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23117704
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.22634533
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20445513
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18788192
59PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.17561781
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17236316
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16168770
62BCOR_27268052_Chip-Seq_Bcells_Human1.15917584
63BCL6_27268052_Chip-Seq_Bcells_Human1.15669495
64MAF_26560356_Chip-Seq_TH1_Human1.14768174
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13960170
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12661906
67TCF7_22412390_ChIP-Seq_EML_Mouse1.11730955
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.11704709
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11094240
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10718219
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10186389
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09838790
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09785665
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09280075
75P68_20966046_ChIP-Seq_HELA_Human1.08493071
76UTX_26944678_Chip-Seq_JUKART_Human1.07996854
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07958327
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07547333
79KDM2B_26808549_Chip-Seq_DND41_Human1.07408738
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07341726
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06428554
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06066342
83SMC4_20622854_ChIP-Seq_HELA_Human1.06036530
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05193547
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05131483
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.04630306
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04511556
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04511556
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.03740659
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03722841
91MAF_26560356_Chip-Seq_TH2_Human1.03465840
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03302228
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03165887
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02347562
95RXR_22108803_ChIP-Seq_LS180_Human1.01490556
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01399434
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01096727
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.00871640
99KDM2B_26808549_Chip-Seq_K562_Human1.00771749
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00588765
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00122214
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99656038
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99653817
104GATA1_19941826_ChIP-Seq_K562_Human0.99084028
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98540593
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97616434
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96913873
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96705020
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95297741
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95077006
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94808479
112LXR_22292898_ChIP-Seq_THP-1_Human0.94682658
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94268824
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94035263
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93441898
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.92192247
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.92192247
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.90517199
119HNF4A_19822575_ChIP-Seq_HepG2_Human0.88516920
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88130063
121SOX2_20726797_ChIP-Seq_SW620_Human0.86470734
122GATA2_19941826_ChIP-Seq_K562_Human0.82213572
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79695741
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79285788
125GATA4_25053715_ChIP-Seq_YYC3_Human0.78334418
126MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76537677
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.75880060
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.72350031
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.71678560
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71651713
131SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70621186
132BCAT_22108803_ChIP-Seq_LS180_Human0.69818938
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.68859353
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68703993
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.68352315
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67430817
137RACK7_27058665_Chip-Seq_MCF-7_Human0.66530951
138EGR1_19032775_ChIP-ChIP_M12_Human0.65859062
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.65178028
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63905655
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.63884047
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63802441
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63341951
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.61354461
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.61330886
146MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61199079
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.60266290
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59963761
149CBP_21632823_ChIP-Seq_H3396_Human0.58668702
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.58427747
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.58186521
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57911204
153IRF8_22096565_ChIP-ChIP_GC-B_Human0.57467806
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.57362243
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57000038
156EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.56970793
157IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.56202746
158CJUN_26792858_Chip-Seq_BT549_Human0.55486518
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.55065535
160ERG_20517297_ChIP-Seq_VCAP_Human0.53985859
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.53222765
162SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.52785934
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.52390083
164CBP_20019798_ChIP-Seq_JUKART_Human0.52184671
165IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.52184671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.74357451
2MP0005670_abnormal_white_adipose4.74326465
3MP0005360_urolithiasis4.15030837
4MP0004130_abnormal_muscle_cell3.72279392
5MP0005365_abnormal_bile_salt3.70930365
6MP0010329_abnormal_lipoprotein_level3.30407742
7MP0005666_abnormal_adipose_tissue3.24722830
8MP0002837_dystrophic_cardiac_calcinosis2.95853685
9MP0003436_decreased_susceptibility_to2.91542144
10MP0005085_abnormal_gallbladder_physiolo2.76791796
11MP0006082_CNS_inflammation2.76170229
12MP0000013_abnormal_adipose_tissue2.75093031
13MP0003191_abnormal_cellular_cholesterol2.69319107
14MP0004185_abnormal_adipocyte_glucose2.68642628
15MP0008260_abnormal_autophagy2.65695683
16MP0005332_abnormal_amino_acid2.50048949
17MP0008875_abnormal_xenobiotic_pharmacok2.44751374
18MP0005375_adipose_tissue_phenotype2.43990547
19MP0002971_abnormal_brown_adipose2.37004220
20MP0002118_abnormal_lipid_homeostasis2.36706797
21MP0002419_abnormal_innate_immunity2.29535868
22MP0009785_altered_susceptibility_to2.24333573
23MP0002876_abnormal_thyroid_physiology2.14047712
24MP0000858_altered_metastatic_potential2.10390626
25MP0005535_abnormal_body_temperature2.03650115
26MP0005025_abnormal_response_to2.02816520
27MP0008438_abnormal_cutaneous_collagen1.99601581
28MP0000003_abnormal_adipose_tissue1.97382743
29MP0005451_abnormal_body_composition1.88216981
30MP0003566_abnormal_cell_adhesion1.85935002
31MP0002909_abnormal_adrenal_gland1.80748764
32MP0005584_abnormal_enzyme/coenzyme_acti1.80231969
33MP0003195_calcinosis1.79705111
34MP0005334_abnormal_fat_pad1.79691932
35MP0001533_abnormal_skeleton_physiology1.78859831
36MP0000609_abnormal_liver_physiology1.77030168
37MP0005671_abnormal_response_to1.76611485
38MP0005464_abnormal_platelet_physiology1.76202067
39MP0001661_extended_life_span1.73919756
40MP0003252_abnormal_bile_duct1.72763842
41MP0009643_abnormal_urine_homeostasis1.71696011
42MP0003303_peritoneal_inflammation1.68103352
43MP0003186_abnormal_redox_activity1.64631892
44MP0009840_abnormal_foam_cell1.62390498
45MP0000685_abnormal_immune_system1.61534058
46MP0005000_abnormal_immune_tolerance1.61354546
47MP0002148_abnormal_hypersensitivity_rea1.58231082
48MP0006036_abnormal_mitochondrial_physio1.55771602
49MP0001835_abnormal_antigen_presentation1.55052405
50MP0005319_abnormal_enzyme/_coenzyme1.54792451
51MP0001853_heart_inflammation1.52910585
52MP0004043_abnormal_pH_regulation1.52221174
53MP0009115_abnormal_fat_cell1.51804228
54MP0002078_abnormal_glucose_homeostasis1.51134519
55MP0001756_abnormal_urination1.45744083
56MP0003724_increased_susceptibility_to1.43464558
57MP0004019_abnormal_vitamin_homeostasis1.42376570
58MP0003806_abnormal_nucleotide_metabolis1.42314217
59MP0001764_abnormal_homeostasis1.41102827
60MP0002970_abnormal_white_adipose1.40861955
61MP0005058_abnormal_lysosome_morphology1.40693991
62MP0009780_abnormal_chondrocyte_physiolo1.40520406
63MP0001666_abnormal_nutrient_absorption1.38880636
64MP0004947_skin_inflammation1.36372955
65MP0004147_increased_porphyrin_level1.34158104
66MP0000920_abnormal_myelination1.32858658
67MP0003183_abnormal_peptide_metabolism1.29478879
68MP0005448_abnormal_energy_balance1.28822078
69MP0002998_abnormal_bone_remodeling1.27462098
70MP0003705_abnormal_hypodermis_morpholog1.26489627
71MP0003011_delayed_dark_adaptation1.25537278
72MP0001845_abnormal_inflammatory_respons1.24864401
73MP0002723_abnormal_immune_serum1.24816380
74MP0001790_abnormal_immune_system1.23815365
75MP0005387_immune_system_phenotype1.23815365
76MP0003690_abnormal_glial_cell1.23363300
77MP0003329_amyloid_beta_deposits1.23230395
78MP0003959_abnormal_lean_body1.21156663
79MP0000604_amyloidosis1.20815167
80MP0003656_abnormal_erythrocyte_physiolo1.20274578
81MP0008961_abnormal_basal_metabolism1.20177187
82MP0003448_altered_tumor_morphology1.18527386
83MP0002420_abnormal_adaptive_immunity1.18508057
84MP0001819_abnormal_immune_cell1.17430411
85MP0004883_abnormal_blood_vessel1.15467382
86MP0009764_decreased_sensitivity_to1.13295173
87MP0005275_abnormal_skin_tensile1.12689747
88MP0002452_abnormal_antigen_presenting1.09983362
89MP0005636_abnormal_mineral_homeostasis1.09484925
90MP0002405_respiratory_system_inflammati1.07041550
91MP0001765_abnormal_ion_homeostasis1.04538188
92MP0000230_abnormal_systemic_arterial1.03963765
93MP0009333_abnormal_splenocyte_physiolog1.02663138
94MP0005452_abnormal_adipose_tissue1.00208206
95MP0001501_abnormal_sleep_pattern0.98157844
96MP0004272_abnormal_basement_membrane0.97375325
97MP0005083_abnormal_biliary_tract0.96840484
98MP0003122_maternal_imprinting0.96802955
99MP0005165_increased_susceptibility_to0.95311207
100MP0003953_abnormal_hormone_level0.94143650
101MP0005023_abnormal_wound_healing0.93542933
102MP0002132_abnormal_respiratory_system0.92252077
103MP0005257_abnormal_intraocular_pressure0.90609026
104MP0001958_emphysema0.89347848
105MP0000751_myopathy0.87184144
106MP0001800_abnormal_humoral_immune0.86943885
107MP0010155_abnormal_intestine_physiology0.86827723
108MP0003646_muscle_fatigue0.86813831
109MP0005408_hypopigmentation0.85366224
110MP0001915_intracranial_hemorrhage0.83448513
111MP0004858_abnormal_nervous_system0.83121398
112MP0003878_abnormal_ear_physiology0.83086283
113MP0005377_hearing/vestibular/ear_phenot0.83086283
114MP0005166_decreased_susceptibility_to0.82197335
115MP0001851_eye_inflammation0.81678390
116MP0006138_congestive_heart_failure0.81637636
117MP0002136_abnormal_kidney_physiology0.81238766
118MP0003453_abnormal_keratinocyte_physiol0.80452744
119MP0001881_abnormal_mammary_gland0.80365313
120MP0005330_cardiomyopathy0.78719845
121MP0005164_abnormal_response_to0.78599238
122MP0003866_abnormal_defecation0.78463090
123MP0009642_abnormal_blood_homeostasis0.77534741
124MP0003300_gastrointestinal_ulcer0.76370168
125MP0008775_abnormal_heart_ventricle0.76353429
126MP0005390_skeleton_phenotype0.75520038
127MP0001542_abnormal_bone_strength0.75236732
128MP0003879_abnormal_hair_cell0.75028096
129MP0010234_abnormal_vibrissa_follicle0.73839690
130MP0000716_abnormal_immune_system0.73338068
131MP0005376_homeostasis/metabolism_phenot0.72791335
132MP0003172_abnormal_lysosome_physiology0.72416672
133MP0000598_abnormal_liver_morphology0.72148768
134MP0003795_abnormal_bone_structure0.70359313
135MP0003634_abnormal_glial_cell0.69981722
136MP0005167_abnormal_blood-brain_barrier0.68980220
137MP0009763_increased_sensitivity_to0.68059661
138MP0001944_abnormal_pancreas_morphology0.66367316
139MP0003221_abnormal_cardiomyocyte_apopto0.64934577
140MP0002796_impaired_skin_barrier0.63578664
141MP0003075_altered_response_to0.62481173
142MP0000343_altered_response_to0.61462468
143MP0001544_abnormal_cardiovascular_syste0.61235460
144MP0005385_cardiovascular_system_phenoty0.61235460
145MP0002090_abnormal_vision0.60687815
146MP0000747_muscle_weakness0.60050790
147MP0008469_abnormal_protein_level0.59335531
148MP0002877_abnormal_melanocyte_morpholog0.59306525
149MP0002069_abnormal_eating/drinking_beha0.58997992
150MP0003633_abnormal_nervous_system0.57953001
151MP0003868_abnormal_feces_composition0.57234083
152MP0005620_abnormal_muscle_contractility0.56932034
153MP0002269_muscular_atrophy0.56531684
154MP0004215_abnormal_myocardial_fiber0.55923109
155MP0001177_atelectasis0.55260342
156MP0002168_other_aberrant_phenotype0.54291836
157MP0002138_abnormal_hepatobiliary_system0.53682514

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.14529456
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.14529456
3Abnormality of glycolipid metabolism (HP:0010969)5.14529456
4Hyperglycinuria (HP:0003108)4.87286851
5Systemic lupus erythematosus (HP:0002725)4.68964450
6Ketoacidosis (HP:0001993)4.63750327
7Ketosis (HP:0001946)4.61132133
8Abnormality of glycine metabolism (HP:0010895)4.46912413
9Abnormality of serine family amino acid metabolism (HP:0010894)4.46912413
10Hypoglycemic coma (HP:0001325)4.36909336
11Abnormality of fatty-acid metabolism (HP:0004359)4.34988179
12Oligomenorrhea (HP:0000876)4.24255954
13Xanthomatosis (HP:0000991)3.99223866
14Hyperlipoproteinemia (HP:0010980)3.89688010
15Hyperammonemia (HP:0001987)3.81521032
16Complement deficiency (HP:0004431)3.65494593
17Eczematoid dermatitis (HP:0000976)3.62916843
18Hyperglycinemia (HP:0002154)3.58643562
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.57253879
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56984503
21Abnormality of macrophages (HP:0004311)3.56918864
22Recurrent gram-negative bacterial infections (HP:0005420)3.53433898
23Dysostosis multiplex (HP:0000943)3.45554161
24Orchitis (HP:0100796)3.44405436
25Abnormality of dicarboxylic acid metabolism (HP:0010995)3.42698231
26Dicarboxylic aciduria (HP:0003215)3.42698231
27Hypertriglyceridemia (HP:0002155)3.40064675
28Glomerulonephritis (HP:0000099)3.32236846
29Generalized aminoaciduria (HP:0002909)3.30830864
30Myositis (HP:0100614)3.28996618
31Hypoalphalipoproteinemia (HP:0003233)3.26760817
32Purpura (HP:0000979)3.20832292
33Vertebral compression fractures (HP:0002953)3.20548372
34Myoglobinuria (HP:0002913)3.16608081
35Abnormality of purine metabolism (HP:0004352)3.14091727
36Abnormality of mucopolysaccharide metabolism (HP:0011020)3.13477771
37Abnormality of polysaccharide metabolism (HP:0011012)3.13477771
38Abnormality of glycosaminoglycan metabolism (HP:0004371)3.13477771
39Gout (HP:0001997)3.08817201
40Acanthosis nigricans (HP:0000956)3.07038819
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06175461
42Increased cerebral lipofuscin (HP:0011813)3.01461487
43Vacuolated lymphocytes (HP:0001922)3.00994353
44Deep venous thrombosis (HP:0002625)3.00037062
45Optic neuritis (HP:0100653)2.99612389
46Retrobulbar optic neuritis (HP:0100654)2.99612389
47Recurrent abscess formation (HP:0002722)2.99303518
48Amyloidosis (HP:0011034)2.98726257
49Neurofibrillary tangles (HP:0002185)2.95325568
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.88973490
51Joint hemorrhage (HP:0005261)2.87178672
52Hydroxyprolinuria (HP:0003080)2.86666531
53Abnormality of proline metabolism (HP:0010907)2.86666531
54Intrahepatic cholestasis (HP:0001406)2.85046438
55Prolonged neonatal jaundice (HP:0006579)2.78778966
56Cerebral inclusion bodies (HP:0100314)2.78531940
57Insulin-resistant diabetes mellitus (HP:0000831)2.74517947
58Epidermoid cyst (HP:0200040)2.72135962
59Hyperuricemia (HP:0002149)2.69403345
60Increased purine levels (HP:0004368)2.69403345
61Hypolipoproteinemia (HP:0010981)2.65647087
62Increased muscle lipid content (HP:0009058)2.62560222
63Hepatic necrosis (HP:0002605)2.62064521
64Metabolic acidosis (HP:0001942)2.60779457
65Loss of speech (HP:0002371)2.58210903
66Recurrent bacterial skin infections (HP:0005406)2.53540275
67Axonal loss (HP:0003447)2.52941426
68Pancreatitis (HP:0001733)2.52671966
69Gingival bleeding (HP:0000225)2.51359649
70Vomiting (HP:0002013)2.50217938
71Lethargy (HP:0001254)2.47563249
72Elevated erythrocyte sedimentation rate (HP:0003565)2.47002880
73Abnormality of complement system (HP:0005339)2.46320925
74Nausea (HP:0002018)2.43196991
75Cerebral edema (HP:0002181)2.41669384
76J-shaped sella turcica (HP:0002680)2.41107162
77Upper motor neuron abnormality (HP:0002127)2.38549995
78Growth hormone excess (HP:0000845)2.38243633
79Skin nodule (HP:0200036)2.35853762
80Proximal tubulopathy (HP:0000114)2.35481851
81Abnormality of serum amino acid levels (HP:0003112)2.32888492
82Hepatosplenomegaly (HP:0001433)2.32433801
83Insulin resistance (HP:0000855)2.30734120
84Abnormality of the common coagulation pathway (HP:0010990)2.30664477
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.28120801
86Mitral stenosis (HP:0001718)2.27156175
87Brushfield spots (HP:0001088)2.26551141
88Myocardial infarction (HP:0001658)2.25657450
89Mutism (HP:0002300)2.24953758
90Hypokalemic alkalosis (HP:0001949)2.24256778
91Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23354479
92Peritonitis (HP:0002586)2.23100105
93Delayed CNS myelination (HP:0002188)2.22479893
94Pheochromocytoma (HP:0002666)2.19340878
95Interstitial pulmonary disease (HP:0006530)2.19258943
96Methylmalonic aciduria (HP:0012120)2.16805092
97Glomerulopathy (HP:0100820)2.16641491
98Hypoglycemic seizures (HP:0002173)2.14767587
99Nephritis (HP:0000123)2.14585430
100Abnormality of nucleobase metabolism (HP:0010932)2.14467950
101Chronic obstructive pulmonary disease (HP:0006510)2.13035255
102Obstructive lung disease (HP:0006536)2.13035255
103Rhabdomyolysis (HP:0003201)2.12636991
104Increased IgM level (HP:0003496)2.12439810
105Progressive neurologic deterioration (HP:0002344)2.11294862
106Conjunctival hamartoma (HP:0100780)2.10823093
107Hyperglycemia (HP:0003074)2.10560110
108Sensorimotor neuropathy (HP:0007141)2.08730355
109Gingivitis (HP:0000230)2.07222722
110Pathologic fracture (HP:0002756)2.06940420
111Abnormality of the intrinsic pathway (HP:0010989)2.06890565
112Hypobetalipoproteinemia (HP:0003563)2.05761421
113Tachypnea (HP:0002789)2.03688385
114Neuronal loss in central nervous system (HP:0002529)2.02232025
115Keratoconjunctivitis sicca (HP:0001097)2.02046347
116Hypercholesterolemia (HP:0003124)2.00409792
117Premature rupture of membranes (HP:0001788)2.00052909
118Prolonged partial thromboplastin time (HP:0003645)1.99731691
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99116040
120Protrusio acetabuli (HP:0003179)1.98803391
121Pulmonary embolism (HP:0002204)1.98554782
122Abnormality of the Achilles tendon (HP:0005109)1.97474653
123Bone cyst (HP:0012062)1.96472366
124Recurrent skin infections (HP:0001581)1.95468592
125Hyperinsulinemic hypoglycemia (HP:0000825)1.94764230
126Abnormal cartilage morphology (HP:0002763)1.94604123
127Cholecystitis (HP:0001082)1.94599999
128Abnormal gallbladder physiology (HP:0012438)1.94599999
129Mediastinal lymphadenopathy (HP:0100721)1.94211742
130Neoplasm of the adrenal gland (HP:0100631)1.92177243
131Abnormality of sulfur amino acid metabolism (HP:0004339)1.92146113
132Acute encephalopathy (HP:0006846)1.91622391
133Increased IgE level (HP:0003212)1.90833300
134Supranuclear gaze palsy (HP:0000605)1.90792511
135Gastrointestinal infarctions (HP:0005244)1.89604590
136Neuroendocrine neoplasm (HP:0100634)1.88664097
137Abnormality of alanine metabolism (HP:0010916)1.87072356
138Hyperalaninemia (HP:0003348)1.87072356
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87072356
140Increased serum ferritin (HP:0003281)1.86452253
141Late onset (HP:0003584)1.86196673
142Hand muscle atrophy (HP:0009130)1.85383271
143Encephalitis (HP:0002383)1.85288750
144Achilles tendon contracture (HP:0001771)1.84859517
145Pulmonary infiltrates (HP:0002113)1.84525364
146Hyperbilirubinemia (HP:0002904)1.84016709
147Neonatal onset (HP:0003623)1.83367479
148Hyperactive renin-angiotensin system (HP:0000841)1.82688853
149Abnormal eating behavior (HP:0100738)1.81734157
150Increased serum pyruvate (HP:0003542)1.81443308
151Abnormality of glycolysis (HP:0004366)1.81443308
152Epistaxis (HP:0000421)1.81209897
153Meningitis (HP:0001287)1.80305236
154Cerebral hemorrhage (HP:0001342)1.78553999
155Menorrhagia (HP:0000132)1.78418600
156Petechiae (HP:0000967)1.78291646
157Cerebral aneurysm (HP:0004944)1.76886423
158Hepatocellular necrosis (HP:0001404)1.75237366
159Urinary glycosaminoglycan excretion (HP:0003541)1.74965627
160Mucopolysacchariduria (HP:0008155)1.74965627
161Distal upper limb amyotrophy (HP:0007149)1.73411816
162Upper limb amyotrophy (HP:0009129)1.73411816
163Arterial thrombosis (HP:0004420)1.72625202
164Joint swelling (HP:0001386)1.72505596
165Acute hepatic failure (HP:0006554)1.71694647
166Hypergammaglobulinemia (HP:0010702)1.71278500
167Nuclear cataract (HP:0100018)1.70645159
168Epiphyseal stippling (HP:0010655)1.70026728
169Irritability (HP:0000737)1.69971268
170Conjugated hyperbilirubinemia (HP:0002908)1.68898987
171Gangrene (HP:0100758)1.68282076
172Keratoconjunctivitis (HP:0001096)1.68225451
173Hemorrhage of the eye (HP:0011885)1.67308840
174Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.66810604
175Global brain atrophy (HP:0002283)1.66809510
176Urticaria (HP:0001025)1.66193151
177Lactic acidosis (HP:0003128)1.66010964
178Tetraparesis (HP:0002273)1.64805392
179Tetraplegia (HP:0002445)1.64625952
180Thrombophlebitis (HP:0004418)1.63919219
181Alkalosis (HP:0001948)1.63396238
182Abnormality of urine glucose concentration (HP:0011016)1.62985681
183Glycosuria (HP:0003076)1.62985681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.30193481
2TRIB34.37911733
3ERN14.17826899
4SIK13.47460789
5CAMK1D3.41477827
6TESK23.26266356
7TESK12.43291683
8PDK42.39855583
9PDK32.39855583
10CAMK1G2.25371509
11EPHA32.22938622
12TXK2.20627497
13MAP3K112.17717984
14PKN22.09219366
15CAMKK22.00555067
16LMTK21.89886572
17INSRR1.80045912
18MAP4K11.79068836
19IRAK41.70476716
20FGFR41.63862138
21WNK41.60166587
22CSK1.56869354
23TIE11.54153985
24SIK21.52956785
25OXSR11.50647999
26LIMK11.46411649
27FES1.44870529
28ZAP701.42975223
29BLK1.40153852
30NTRK31.39052123
31MST1R1.38833700
32KSR21.38470199
33EPHA21.36902502
34GRK61.36345135
35PRPF4B1.35585092
36PAK41.35316581
37PDK21.31912218
38WNK31.29440463
39MAP2K41.26541572
40NME21.24269581
41FLT31.19094584
42MAP2K11.18976741
43DAPK21.18879719
44NTRK11.17991983
45SIK31.16312140
46RIPK11.15502434
47TAOK21.14892786
48FRK1.12414474
49PRKAA21.08696719
50RIPK41.08054982
51PDPK11.07393846
52RET1.07284841
53SCYL21.00155514
54KDR0.99793367
55FGR0.99636396
56TGFBR20.97715559
57MAPKAPK30.97561647
58CAMKK10.96856581
59TAOK10.95977391
60JAK20.95660839
61PINK10.95459813
62FER0.93153167
63PIM20.92146809
64MAP3K20.91927030
65PDK10.91072852
66CSF1R0.89485228
67MOS0.86614651
68JAK10.83436388
69MYLK0.82621399
70MAP3K140.80709073
71SMG10.79526045
72PDGFRA0.79189501
73PRKCH0.78736451
74GRK70.74286819
75MAP3K130.73970662
76GRK50.72570005
77PTK20.70630969
78JAK30.69380324
79FGFR20.69132169
80LRRK20.67837249
81PRKD20.66692895
82DAPK10.65855100
83MAPK110.65292771
84MINK10.64736350
85PRKAA10.64184968
86ABL20.63554553
87HCK0.63340191
88MAP3K60.63327987
89IRAK30.62960688
90PRKACG0.62270660
91STK380.62137771
92FGFR30.59953941
93DYRK1B0.59892847
94EPHA40.58972639
95FYN0.58965562
96MAP3K90.58066682
97NEK10.57494298
98MAP3K120.55980492
99ICK0.55407091
100MAP3K10.55226280
101SGK4940.55176991
102SGK2230.55176991
103ARAF0.54925501
104MAP2K60.54786135
105LCK0.54705202
106TYK20.54321099
107MAP3K50.52346210
108CDK90.50657033
109SGK30.50644147
110MAPKAPK20.50354314
111IGF1R0.49914075
112TYRO30.49316209
113PIK3CG0.47944798
114EPHB20.47780393
115PTK60.46014910
116IKBKB0.45879005
117PRKCD0.45328296
118GSK3A0.45319729
119CDK50.45235104
120RPS6KA20.44843997
121PAK60.44121614
122PRKCI0.43690127
123CAMK10.43631461
124MAP3K70.43362206
125LYN0.42483490
126MATK0.42335788
127TNK20.42217811
128CDK190.42212333
129ILK0.42134039
130CDC42BPA0.41323508
131SRC0.40863946
132TTN0.39802865
133PRKCZ0.39739510
134MARK20.38216359
135EEF2K0.38167230
136MAPK120.38133722
137KSR10.37434526
138TAOK30.37172473
139STK390.37079131
140CDK60.36778209
141TBK10.35984752
142PAK30.35676492
143MAPK40.34748158
144LATS10.33808159
145IRAK10.32892681
146EPHB10.32513789
147PRKG20.32251276
148RAF10.30661247
149SGK20.30558493
150NEK90.30231232
151MAP3K30.28597141
152MAP2K30.28462946
153RPS6KB10.27856351
154PDGFRB0.27791147
155PRKD10.27358477

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.65305191
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.50554293
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.41452708
4Fatty acid degradation_Homo sapiens_hsa000713.15075544
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02353458
6Fatty acid metabolism_Homo sapiens_hsa012122.97558282
7PPAR signaling pathway_Homo sapiens_hsa033202.88069039
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71978827
9Nitrogen metabolism_Homo sapiens_hsa009102.50177953
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.40505717
11Butanoate metabolism_Homo sapiens_hsa006502.38322927
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.28324764
13Fatty acid biosynthesis_Homo sapiens_hsa000612.23707423
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20892515
15Pyruvate metabolism_Homo sapiens_hsa006202.15014486
16Peroxisome_Homo sapiens_hsa041462.07360148
17Tryptophan metabolism_Homo sapiens_hsa003801.96172717
18beta-Alanine metabolism_Homo sapiens_hsa004101.89429316
19Carbon metabolism_Homo sapiens_hsa012001.87342053
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84089975
21Antigen processing and presentation_Homo sapiens_hsa046121.76134062
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72395674
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71871938
24Fatty acid elongation_Homo sapiens_hsa000621.67080418
25Glycerolipid metabolism_Homo sapiens_hsa005611.66646295
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65287513
27Arginine biosynthesis_Homo sapiens_hsa002201.64658148
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.58730579
29Sulfur metabolism_Homo sapiens_hsa009201.56311861
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51160899
31Osteoclast differentiation_Homo sapiens_hsa043801.47069210
32Pertussis_Homo sapiens_hsa051331.41149902
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40675221
34Caffeine metabolism_Homo sapiens_hsa002321.38008379
35Malaria_Homo sapiens_hsa051441.35201340
36Phagosome_Homo sapiens_hsa041451.34429880
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30447857
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29358355
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22184432
40Salmonella infection_Homo sapiens_hsa051321.21750442
41Phenylalanine metabolism_Homo sapiens_hsa003601.20143388
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17415656
43Complement and coagulation cascades_Homo sapiens_hsa046101.17033344
44Leishmaniasis_Homo sapiens_hsa051401.16564694
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14791952
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.09602633
47Fat digestion and absorption_Homo sapiens_hsa049751.09327997
48Biosynthesis of amino acids_Homo sapiens_hsa012301.07585100
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03865177
50Tuberculosis_Homo sapiens_hsa051521.03746873
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03717760
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03713686
53Acute myeloid leukemia_Homo sapiens_hsa052211.03421350
54Shigellosis_Homo sapiens_hsa051311.03228234
55Starch and sucrose metabolism_Homo sapiens_hsa005001.00782045
56Bile secretion_Homo sapiens_hsa049760.99213346
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97283383
58Tyrosine metabolism_Homo sapiens_hsa003500.95878779
59Histidine metabolism_Homo sapiens_hsa003400.95028676
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94696498
61Legionellosis_Homo sapiens_hsa051340.93895270
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91382557
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90755206
64Staphylococcus aureus infection_Homo sapiens_hsa051500.86335406
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84912279
66Graft-versus-host disease_Homo sapiens_hsa053320.83264660
67AMPK signaling pathway_Homo sapiens_hsa041520.83195568
68ABC transporters_Homo sapiens_hsa020100.81971304
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80924960
70Pentose phosphate pathway_Homo sapiens_hsa000300.79131976
71Chemical carcinogenesis_Homo sapiens_hsa052040.77879104
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.76663419
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74471265
74Folate biosynthesis_Homo sapiens_hsa007900.74242735
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73949378
76Insulin resistance_Homo sapiens_hsa049310.73824888
77Steroid biosynthesis_Homo sapiens_hsa001000.71089519
78Selenocompound metabolism_Homo sapiens_hsa004500.67516381
79Hepatitis C_Homo sapiens_hsa051600.63364708
80Endocytosis_Homo sapiens_hsa041440.63243699
81Amoebiasis_Homo sapiens_hsa051460.61642986
82Rheumatoid arthritis_Homo sapiens_hsa053230.60913357
83TNF signaling pathway_Homo sapiens_hsa046680.60896358
84Apoptosis_Homo sapiens_hsa042100.59972458
85Toxoplasmosis_Homo sapiens_hsa051450.59438970
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58451686
87Measles_Homo sapiens_hsa051620.58313896
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.57546896
89Sulfur relay system_Homo sapiens_hsa041220.56756363
90Insulin signaling pathway_Homo sapiens_hsa049100.55841181
91Retinol metabolism_Homo sapiens_hsa008300.55754024
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.55155590
93Glucagon signaling pathway_Homo sapiens_hsa049220.53190541
94Hematopoietic cell lineage_Homo sapiens_hsa046400.53032206
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.52047984
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.52008830
97Fructose and mannose metabolism_Homo sapiens_hsa000510.50435564
98Lysosome_Homo sapiens_hsa041420.49115327
99Chemokine signaling pathway_Homo sapiens_hsa040620.48633271
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48331028
101HIF-1 signaling pathway_Homo sapiens_hsa040660.46502322
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46317416
103Vitamin digestion and absorption_Homo sapiens_hsa049770.46019788
104Collecting duct acid secretion_Homo sapiens_hsa049660.45539144
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44917561
106Metabolic pathways_Homo sapiens_hsa011000.44292479
107Lysine degradation_Homo sapiens_hsa003100.43732481
108Vitamin B6 metabolism_Homo sapiens_hsa007500.43044613
109Arginine and proline metabolism_Homo sapiens_hsa003300.42922314
110VEGF signaling pathway_Homo sapiens_hsa043700.42799851
111Non-small cell lung cancer_Homo sapiens_hsa052230.42024529
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.41945773
113T cell receptor signaling pathway_Homo sapiens_hsa046600.41470536
114mTOR signaling pathway_Homo sapiens_hsa041500.41187912
115Galactose metabolism_Homo sapiens_hsa000520.40921624
116Oxidative phosphorylation_Homo sapiens_hsa001900.40381950
117Pancreatic cancer_Homo sapiens_hsa052120.38718808
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.37773094
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37197037
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36770600
121Autoimmune thyroid disease_Homo sapiens_hsa053200.36520355
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.36491952
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36061406
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35835294
125Type II diabetes mellitus_Homo sapiens_hsa049300.35695255
126Glutathione metabolism_Homo sapiens_hsa004800.35388397
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.32596369
128Renin secretion_Homo sapiens_hsa049240.32522617
129Thyroid hormone synthesis_Homo sapiens_hsa049180.31863830
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30956330
131Protein digestion and absorption_Homo sapiens_hsa049740.30611507
132Vibrio cholerae infection_Homo sapiens_hsa051100.29791150
133N-Glycan biosynthesis_Homo sapiens_hsa005100.27498728
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27063172
135Synaptic vesicle cycle_Homo sapiens_hsa047210.26898374
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24362639
137Alzheimers disease_Homo sapiens_hsa050100.23496841
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.23007255
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22519465
140Renin-angiotensin system_Homo sapiens_hsa046140.22255181
141Parkinsons disease_Homo sapiens_hsa050120.21601971
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20435894
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.19568059
144Other glycan degradation_Homo sapiens_hsa005110.18628476
145Prion diseases_Homo sapiens_hsa050200.16565757
146Protein export_Homo sapiens_hsa030600.12776746

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