APOA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of heterotypic cell-cell adhesion (GO:0034116)7.91329993
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.26922532
3L-phenylalanine catabolic process (GO:0006559)7.26922532
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)7.13474857
5L-phenylalanine metabolic process (GO:0006558)6.99901826
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.99901826
7aromatic amino acid family catabolic process (GO:0009074)6.44750198
8* high-density lipoprotein particle remodeling (GO:0034375)5.83481083
9negative regulation of fibrinolysis (GO:0051918)5.76922758
10indole-containing compound catabolic process (GO:0042436)5.74328698
11indolalkylamine catabolic process (GO:0046218)5.74328698
12tryptophan catabolic process (GO:0006569)5.74328698
13glyoxylate metabolic process (GO:0046487)5.70962182
14kynurenine metabolic process (GO:0070189)5.69817855
15urea cycle (GO:0000050)5.66015011
16urea metabolic process (GO:0019627)5.66015011
17bile acid biosynthetic process (GO:0006699)5.62141096
18alpha-linolenic acid metabolic process (GO:0036109)5.55920345
19regulation of fibrinolysis (GO:0051917)5.53169637
20* negative regulation of lipase activity (GO:0060192)5.50038505
21regulation of triglyceride catabolic process (GO:0010896)5.41704138
22tryptophan metabolic process (GO:0006568)5.41599129
23peptidyl-glutamic acid carboxylation (GO:0017187)5.29487877
24protein carboxylation (GO:0018214)5.29487877
25sulfur amino acid catabolic process (GO:0000098)5.24058730
26cysteine metabolic process (GO:0006534)5.22291574
27* reverse cholesterol transport (GO:0043691)5.21815829
28epoxygenase P450 pathway (GO:0019373)5.19606652
29nitrogen cycle metabolic process (GO:0071941)5.19468684
30regulation of protein activation cascade (GO:2000257)5.11629805
31* macromolecular complex remodeling (GO:0034367)5.08479403
32* plasma lipoprotein particle remodeling (GO:0034369)5.08479403
33* protein-lipid complex remodeling (GO:0034368)5.08479403
34* regulation of cholesterol esterification (GO:0010872)5.01875754
35complement activation, alternative pathway (GO:0006957)4.97403173
36negative regulation of cholesterol transport (GO:0032375)4.96702688
37negative regulation of sterol transport (GO:0032372)4.96702688
38bile acid metabolic process (GO:0008206)4.92259987
39serine family amino acid catabolic process (GO:0009071)4.90892160
40* phospholipid efflux (GO:0033700)4.84510920
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79521639
42regulation of complement activation (GO:0030449)4.73358129
43aromatic amino acid family metabolic process (GO:0009072)4.69590159
44* triglyceride homeostasis (GO:0070328)4.62076535
45* acylglycerol homeostasis (GO:0055090)4.62076535
46tyrosine metabolic process (GO:0006570)4.61786709
47homocysteine metabolic process (GO:0050667)4.61038001
48* cholesterol efflux (GO:0033344)4.58186794
49amino-acid betaine metabolic process (GO:0006577)4.54860903
50* plasma lipoprotein particle clearance (GO:0034381)4.49830959
51positive regulation of lipoprotein lipase activity (GO:0051006)4.49438605
52positive regulation of triglyceride lipase activity (GO:0061365)4.49438605
53cellular ketone body metabolic process (GO:0046950)4.46666816
54alpha-amino acid catabolic process (GO:1901606)4.41649432
55bile acid and bile salt transport (GO:0015721)4.41501900
56lysine catabolic process (GO:0006554)4.39370923
57lysine metabolic process (GO:0006553)4.39370923
58* plasma lipoprotein particle assembly (GO:0034377)4.32963001
59regulation of lipoprotein particle clearance (GO:0010984)4.32494568
60lipoprotein transport (GO:0042953)4.26139452
61* sterol transport (GO:0015918)4.23349096
62* cholesterol transport (GO:0030301)4.23349096
63diacylglycerol metabolic process (GO:0046339)4.18831801
64* regulation of heterotypic cell-cell adhesion (GO:0034114)4.17089793
65glycine metabolic process (GO:0006544)4.16753292
66low-density lipoprotein particle remodeling (GO:0034374)4.16636486
67glutamate metabolic process (GO:0006536)4.14418630
68intestinal cholesterol absorption (GO:0030299)4.14144541
69very-low-density lipoprotein particle assembly (GO:0034379)4.13095527
70exogenous drug catabolic process (GO:0042738)4.12785002
71drug catabolic process (GO:0042737)4.09534340
72cellular amino acid catabolic process (GO:0009063)4.08033760
73positive regulation of lipid catabolic process (GO:0050996)4.07877766
74indolalkylamine metabolic process (GO:0006586)4.06658890
75fibrinolysis (GO:0042730)4.06249022
76coenzyme catabolic process (GO:0009109)4.05959738
77proline metabolic process (GO:0006560)4.04990287
78arginine metabolic process (GO:0006525)4.04602509
79imidazole-containing compound metabolic process (GO:0052803)4.04472966
80cellular glucuronidation (GO:0052695)4.01445380
81serine family amino acid metabolic process (GO:0009069)3.99468329
82drug metabolic process (GO:0017144)3.98919519
83* cholesterol homeostasis (GO:0042632)3.98465660
84cellular modified amino acid catabolic process (GO:0042219)3.98461137
85negative regulation of hemostasis (GO:1900047)3.97770210
86negative regulation of blood coagulation (GO:0030195)3.97770210
87amine catabolic process (GO:0009310)3.96991174
88cellular biogenic amine catabolic process (GO:0042402)3.96991174
89L-ascorbic acid metabolic process (GO:0019852)3.95584602
90blood coagulation, intrinsic pathway (GO:0007597)3.93627698
91benzene-containing compound metabolic process (GO:0042537)3.93272153
92serine family amino acid biosynthetic process (GO:0009070)3.92157681
93* sterol homeostasis (GO:0055092)3.91812125
94* plasma lipoprotein particle organization (GO:0071827)3.90573155
95dicarboxylic acid biosynthetic process (GO:0043650)3.90560321
96intestinal absorption (GO:0050892)3.89445426
97* protein-lipid complex assembly (GO:0065005)3.88510838
98aldehyde catabolic process (GO:0046185)3.87819390
99ketone body metabolic process (GO:1902224)3.86246244
100omega-hydroxylase P450 pathway (GO:0097267)3.84440332
101regulation of bile acid biosynthetic process (GO:0070857)3.82730719
102* lipoprotein metabolic process (GO:0042157)3.79469992
103ethanol oxidation (GO:0006069)3.77697525
104regulation of cholesterol homeostasis (GO:2000188)3.72257142
105flavonoid metabolic process (GO:0009812)3.71338348
106* protein-lipid complex subunit organization (GO:0071825)3.68209586
107negative regulation of protein activation cascade (GO:2000258)3.67637630
108negative regulation of coagulation (GO:0050819)3.66943143
109heme transport (GO:0015886)3.66569857
110acylglycerol catabolic process (GO:0046464)3.65992847
111neutral lipid catabolic process (GO:0046461)3.65992847
112cofactor catabolic process (GO:0051187)3.64879239
113* positive regulation of steroid metabolic process (GO:0045940)3.62655404
114negative regulation of fatty acid biosynthetic process (GO:0045717)3.61852371
115protein activation cascade (GO:0072376)3.61659546
116organic acid catabolic process (GO:0016054)3.60772524
117carboxylic acid catabolic process (GO:0046395)3.60772524
118positive regulation of fatty acid biosynthetic process (GO:0045723)3.60272004
119glucuronate metabolic process (GO:0019585)3.56008235
120uronic acid metabolic process (GO:0006063)3.56008235
121acute-phase response (GO:0006953)3.55724046
122complement activation, classical pathway (GO:0006958)3.54321438
123regulation of plasminogen activation (GO:0010755)3.52296083
124complement activation (GO:0006956)3.50743065
125negative regulation of wound healing (GO:0061045)3.46318521
126phenylpropanoid metabolic process (GO:0009698)3.44820057
127negative regulation of lipid transport (GO:0032369)3.44244558
128* regulation of cholesterol transport (GO:0032374)3.37289711
129* regulation of sterol transport (GO:0032371)3.37289711
130* lipid homeostasis (GO:0055088)3.35230592
131regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.26517811
132glutamine family amino acid biosynthetic process (GO:0009084)3.22921932
133regulation of lipoprotein metabolic process (GO:0050746)3.16980266
134* regulation of cytokine secretion involved in immune response (GO:0002739)3.14804853
135regulation of fatty acid biosynthetic process (GO:0042304)3.13430211
136fat-soluble vitamin biosynthetic process (GO:0042362)3.11918473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.26386178
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14202489
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.79215364
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.42775500
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.20606401
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.07343459
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.97064176
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95320886
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88252914
10* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20113222
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18388102
12PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.07724659
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03066633
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9100949
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95658439
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93606794
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.63712666
18CLOCK_20551151_ChIP-Seq_293T_Human1.63566415
19GATA1_22025678_ChIP-Seq_K562_Human1.55137768
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52292755
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46490832
22HTT_18923047_ChIP-ChIP_STHdh_Human1.45815302
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25225797
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18590912
25* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17190919
26RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16818513
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16575484
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12821113
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11313244
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.10998329
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08755985
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08164755
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08078064
34GATA4_25053715_ChIP-Seq_YYC3_Human1.02861283
35EOMES_21245162_ChIP-Seq_HESCs_Human1.01295793
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92806623
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91722069
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89161447
39RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87858163
40AR_21909140_ChIP-Seq_LNCAP_Human0.86445307
41IRF8_22096565_ChIP-ChIP_GC-B_Human0.86046558
42ZNF263_19887448_ChIP-Seq_K562_Human0.83200168
43CDX2_20551321_ChIP-Seq_CACO-2_Human0.82701356
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81871708
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80787388
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80710493
47RARA_24833708_ChIP-Seq_LIVER_Mouse0.78835716
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78566417
49STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77321953
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76429876
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76069899
52TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75770841
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75369280
54KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74931240
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73777049
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73534121
57SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72936013
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72698417
59JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72472206
60* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72298188
61ESR2_21235772_ChIP-Seq_MCF-7_Human0.71797307
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70256514
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68639375
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67226230
65POU5F1_16518401_ChIP-PET_MESCs_Mouse0.67164914
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.66607612
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65091922
68FOXH1_21741376_ChIP-Seq_EPCs_Human0.64829827
69CDX2_22108803_ChIP-Seq_LS180_Human0.64660074
70TP53_16413492_ChIP-PET_HCT116_Human0.64641921
71* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63430493
72* LXR_22292898_ChIP-Seq_THP-1_Human0.63143457
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62745520
74RARB_24833708_ChIP-Seq_LIVER_Mouse0.62709556
75EGR1_19032775_ChIP-ChIP_M12_Human0.62444468
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.61539749
77* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61248185
78SOX2_21211035_ChIP-Seq_LN229_Human0.60985174
79SOX2_22085726_ChIP-Seq_NPCs_Mouse0.60671492
80SMAD3_21741376_ChIP-Seq_HESCs_Human0.60669071
81GATA6_25053715_ChIP-Seq_YYC3_Human0.60478675
82SMAD4_21741376_ChIP-Seq_HESCs_Human0.60174926
83CEBPB_22108803_ChIP-Seq_LS180_Human0.59401766
84BCAT_22108803_ChIP-Seq_LS180_Human0.59100039
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57040010
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.56856563
87* CTCF_27219007_Chip-Seq_Bcells_Human0.56572535
88GATA1_19941826_ChIP-Seq_K562_Human0.56210870
89CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56129799
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55949431
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55949431
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55546747
93HIF1A_21447827_ChIP-Seq_MCF-7_Human0.55378400
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55189855
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.55058546
96FOXA1_25552417_ChIP-Seq_VCAP_Human0.54894500
97MYC_19915707_ChIP-ChIP_AK7_Human0.54428769
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.54351162
99GATA2_19941826_ChIP-Seq_K562_Human0.54155141
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54069748
101MYC_19829295_ChIP-Seq_ESCs_Human0.53925021
102NANOG_19829295_ChIP-Seq_ESCs_Human0.53865155
103SOX2_19829295_ChIP-Seq_ESCs_Human0.53865155
104AR_20517297_ChIP-Seq_VCAP_Human0.53770499
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53404922
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.53369559
107* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.52759251
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.51040722
109SOX2_20726797_ChIP-Seq_SW620_Human0.49988881
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.49324935
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.49246819
112* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47754295
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47153165
114TAF2_19829295_ChIP-Seq_ESCs_Human0.47032319
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46909813
116ESET_19884257_ChIP-Seq_ESCs_Mouse0.46846906
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46334824
118STAT1_17558387_ChIP-Seq_HELA_Human0.45639316
119* P53_21459846_ChIP-Seq_SAOS-2_Human0.44687244
120* CBP_21632823_ChIP-Seq_H3396_Human0.42890926
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.41871309
122* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.40816714
123BCOR_27268052_Chip-Seq_Bcells_Human0.40684250
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.39303344
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.38225965
126MYC_27129775_Chip-Seq_CORNEA_Mouse0.38124391
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37813280
128SPI1_26923725_Chip-Seq_HPCs_Mouse0.37357181
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36890405
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.36225339
131* RACK7_27058665_Chip-Seq_MCF-7_Human0.36081728
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.35552922
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35370556
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35189862
135ERG_20517297_ChIP-Seq_VCAP_Human0.35087268
136SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.35074415
137OCT4_20526341_ChIP-Seq_ESCs_Human0.34731670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25795175
2MP0005360_urolithiasis8.02041033
3MP0005085_abnormal_gallbladder_physiolo6.36984138
4MP0005365_abnormal_bile_salt6.09427867
5MP0008875_abnormal_xenobiotic_pharmacok5.04230096
6MP0003806_abnormal_nucleotide_metabolis4.02886209
7MP0003252_abnormal_bile_duct3.94153189
8* MP0010329_abnormal_lipoprotein_level3.69433808
9MP0001666_abnormal_nutrient_absorption3.09001253
10MP0005083_abnormal_biliary_tract2.96185853
11* MP0009840_abnormal_foam_cell2.94497390
12MP0005332_abnormal_amino_acid2.74083448
13MP0003195_calcinosis2.60666176
14MP0004019_abnormal_vitamin_homeostasis2.28793874
15* MP0000609_abnormal_liver_physiology2.16575146
16* MP0002118_abnormal_lipid_homeostasis2.10474416
17MP0002138_abnormal_hepatobiliary_system1.88732713
18MP0001986_abnormal_taste_sensitivity1.87330770
19MP0003868_abnormal_feces_composition1.86541930
20MP0005319_abnormal_enzyme/_coenzyme1.79357239
21MP0003122_maternal_imprinting1.69858317
22MP0009697_abnormal_copulation1.68518101
23MP0001764_abnormal_homeostasis1.68240817
24MP0005584_abnormal_enzyme/coenzyme_acti1.54799900
25* MP0003191_abnormal_cellular_cholesterol1.54245985
26MP0005451_abnormal_body_composition1.52393710
27MP0003011_delayed_dark_adaptation1.47591104
28MP0008004_abnormal_stomach_pH1.42585554
29MP0003656_abnormal_erythrocyte_physiolo1.39589352
30MP0005058_abnormal_lysosome_morphology1.38748031
31MP0009643_abnormal_urine_homeostasis1.28548027
32MP0003705_abnormal_hypodermis_morpholog1.24210413
33MP0004272_abnormal_basement_membrane1.19725587
34MP0000604_amyloidosis1.19353177
35MP0003186_abnormal_redox_activity1.16945242
36MP0003315_abnormal_perineum_morphology1.16792165
37MP0002254_reproductive_system_inflammat1.16279965
38* MP0000598_abnormal_liver_morphology1.16065387
39MP0003567_abnormal_fetal_cardiomyocyte1.14222916
40MP0003123_paternal_imprinting1.06294416
41MP0009764_decreased_sensitivity_to1.03368170
42MP0000566_synostosis1.02992033
43MP0005647_abnormal_sex_gland0.99661836
44MP0009763_increased_sensitivity_to0.99104615
45MP0010368_abnormal_lymphatic_system0.97581312
46MP0005636_abnormal_mineral_homeostasis0.97008327
47MP0005084_abnormal_gallbladder_morpholo0.95256756
48MP0003183_abnormal_peptide_metabolism0.93593521
49MP0003879_abnormal_hair_cell0.92355582
50* MP0009642_abnormal_blood_homeostasis0.89836643
51MP0008469_abnormal_protein_level0.89717640
52MP0005367_renal/urinary_system_phenotyp0.88956586
53MP0000516_abnormal_urinary_system0.88956586
54MP0003941_abnormal_skin_development0.83534430
55MP0000537_abnormal_urethra_morphology0.82017081
56MP0005408_hypopigmentation0.81847156
57MP0002876_abnormal_thyroid_physiology0.79779921
58MP0009780_abnormal_chondrocyte_physiolo0.79681645
59MP0002078_abnormal_glucose_homeostasis0.79375849
60MP0009765_abnormal_xenobiotic_induced0.79227450
61MP0006036_abnormal_mitochondrial_physio0.77901191
62MP0006054_spinal_hemorrhage0.76941177
63* MP0005376_homeostasis/metabolism_phenot0.76390041
64MP0008260_abnormal_autophagy0.76236180
65MP0009053_abnormal_anal_canal0.75224426
66MP0002089_abnormal_postnatal_growth/wei0.73690346
67MP0002971_abnormal_brown_adipose0.71797195
68MP0005409_darkened_coat_color0.70633408
69MP0005334_abnormal_fat_pad0.68349678
70MP0005448_abnormal_energy_balance0.68264153
71MP0005266_abnormal_metabolism0.67294078
72MP0002090_abnormal_vision0.67009406
73MP0002822_catalepsy0.66960271
74MP0005670_abnormal_white_adipose0.66827283
75MP0005410_abnormal_fertilization0.65397162
76MP0005220_abnormal_exocrine_pancreas0.65333325
77MP0003329_amyloid_beta_deposits0.65219585
78MP0005464_abnormal_platelet_physiology0.62647318
79MP0001915_intracranial_hemorrhage0.61878450
80MP0003690_abnormal_glial_cell0.61310572
81MP0005535_abnormal_body_temperature0.61300376
82MP0001756_abnormal_urination0.61023556
83MP0004130_abnormal_muscle_cell0.57639325
84MP0003718_maternal_effect0.55906577
85MP0004264_abnormal_extraembryonic_tissu0.55789662
86MP0001661_extended_life_span0.53358540
87MP0003638_abnormal_response/metabolism_0.50578886
88MP0002909_abnormal_adrenal_gland0.50545991
89MP0005395_other_phenotype0.50371354
90MP0006035_abnormal_mitochondrial_morpho0.50102235
91MP0002136_abnormal_kidney_physiology0.49745933
92MP0010030_abnormal_orbit_morphology0.46591830
93MP0008873_increased_physiological_sensi0.46431059
94MP0002796_impaired_skin_barrier0.45651699
95MP0002938_white_spotting0.45416398
96MP0008872_abnormal_physiological_respon0.42832631
97MP0005166_decreased_susceptibility_to0.42540863
98MP0003172_abnormal_lysosome_physiology0.42486473
99MP0003953_abnormal_hormone_level0.42384142
100MP0003075_altered_response_to0.42305012
101MP0004270_analgesia0.42156505
102* MP0000639_abnormal_adrenal_gland0.42029339
103MP0003436_decreased_susceptibility_to0.41513623
104MP0003699_abnormal_female_reproductive0.40869417
105MP0000477_abnormal_intestine_morphology0.40216917
106MP0008874_decreased_physiological_sensi0.40212346
107MP0005551_abnormal_eye_electrophysiolog0.40186013
108MP0010234_abnormal_vibrissa_follicle0.39757646
109MP0003890_abnormal_embryonic-extraembry0.38443274
110MP0009115_abnormal_fat_cell0.37359673
111MP0005666_abnormal_adipose_tissue0.37178485
112MP0005248_abnormal_Harderian_gland0.36906957
113MP0002168_other_aberrant_phenotype0.36765576
114MP0004147_increased_porphyrin_level0.36352705
115MP0003119_abnormal_digestive_system0.35336975
116MP0004782_abnormal_surfactant_physiolog0.34684451
117MP0003724_increased_susceptibility_to0.34612320
118MP0002928_abnormal_bile_duct0.33842399
119MP0009672_abnormal_birth_weight0.33814182
120MP0001324_abnormal_eye_pigmentation0.33255738
121MP0005167_abnormal_blood-brain_barrier0.32989986
122MP0000230_abnormal_systemic_arterial0.32854428
123MP0000920_abnormal_myelination0.32712503
124MP0002135_abnormal_kidney_morphology0.32185521
125MP0009384_cardiac_valve_regurgitation0.31872918
126MP0003878_abnormal_ear_physiology0.31579229
127MP0005377_hearing/vestibular/ear_phenot0.31579229
128MP0001845_abnormal_inflammatory_respons0.31563810
129MP0000579_abnormal_nail_morphology0.31521634
130MP0001881_abnormal_mammary_gland0.31181762
131MP0000462_abnormal_digestive_system0.30916341
132MP0002837_dystrophic_cardiac_calcinosis0.30486882
133* MP0000249_abnormal_blood_vessel0.30410597
134MP0006082_CNS_inflammation0.28912790
135MP0002970_abnormal_white_adipose0.28504903
136MP0002132_abnormal_respiratory_system0.27296274
137MP0003300_gastrointestinal_ulcer0.25826951
138MP0005023_abnormal_wound_healing0.24604560
139MP0003453_abnormal_keratinocyte_physiol0.24503058
140MP0000538_abnormal_urinary_bladder0.24278284

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.35724053
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.16363579
3Intrahepatic cholestasis (HP:0001406)7.02192375
4Hypobetalipoproteinemia (HP:0003563)6.83491114
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60234075
6Prolonged partial thromboplastin time (HP:0003645)6.49256908
7Xanthomatosis (HP:0000991)6.42821239
8Hyperlipoproteinemia (HP:0010980)5.47131145
9Complement deficiency (HP:0004431)4.97134965
10Joint hemorrhage (HP:0005261)4.77168919
11* Hypolipoproteinemia (HP:0010981)4.69665374
12Hyperammonemia (HP:0001987)4.58949222
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.53507283
14Abnormality of the common coagulation pathway (HP:0010990)4.49936740
15Epidermoid cyst (HP:0200040)4.41228005
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.26804197
17* Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.24607718
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18667480
19Fat malabsorption (HP:0002630)4.16221250
20Ketosis (HP:0001946)4.15080857
21Abnormality of methionine metabolism (HP:0010901)4.14288464
22Hyperglycinemia (HP:0002154)4.13216946
23Hyperglycinuria (HP:0003108)3.98054835
24Hypoglycemic coma (HP:0001325)3.93909632
25Abnormality of serine family amino acid metabolism (HP:0010894)3.89009252
26Abnormality of glycine metabolism (HP:0010895)3.89009252
27Retinal atrophy (HP:0001105)3.84978962
28Abnormality of pyrimidine metabolism (HP:0004353)3.80090491
29Conjugated hyperbilirubinemia (HP:0002908)3.77047540
30Abnormality of the intrinsic pathway (HP:0010989)3.75216623
31Hypercholesterolemia (HP:0003124)3.74329963
32Abnormality of complement system (HP:0005339)3.63490083
33* Hypoalphalipoproteinemia (HP:0003233)3.55282184
34Hyperbilirubinemia (HP:0002904)3.40480194
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36232889
36Abnormality of fatty-acid metabolism (HP:0004359)3.32143858
37Acanthocytosis (HP:0001927)3.17564304
38Spontaneous abortion (HP:0005268)3.14682315
39Joint swelling (HP:0001386)3.09640732
40Abnormality of nucleobase metabolism (HP:0010932)3.08510151
41Hepatocellular carcinoma (HP:0001402)2.97128970
42Hypochromic microcytic anemia (HP:0004840)2.95241210
43Abnormal delivery (HP:0001787)2.95066671
44Ketoacidosis (HP:0001993)2.94751382
45Nausea (HP:0002018)2.94386829
46Steatorrhea (HP:0002570)2.92312131
47Delayed CNS myelination (HP:0002188)2.88917726
48Abnormality of serum amino acid levels (HP:0003112)2.87175797
49Metabolic acidosis (HP:0001942)2.85237615
50Myocardial infarction (HP:0001658)2.77621828
51Abnormality of purine metabolism (HP:0004352)2.72719981
52Skin nodule (HP:0200036)2.70230601
53Chronic hepatic failure (HP:0100626)2.68878356
54Systemic lupus erythematosus (HP:0002725)2.67249179
55Malnutrition (HP:0004395)2.61094374
56Abnormal gallbladder physiology (HP:0012438)2.60736524
57Cholecystitis (HP:0001082)2.60736524
58Abnormal gallbladder morphology (HP:0012437)2.56156841
59Lethargy (HP:0001254)2.55404669
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55129252
61Dicarboxylic aciduria (HP:0003215)2.55129252
62Vascular calcification (HP:0004934)2.54846942
63Hypoglycemic seizures (HP:0002173)2.53411514
64Cholelithiasis (HP:0001081)2.52132340
65Vacuolated lymphocytes (HP:0001922)2.46229144
66Osteomalacia (HP:0002749)2.45950365
67Poikilocytosis (HP:0004447)2.44730745
68Glomerulonephritis (HP:0000099)2.43464106
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37768084
70Abnormality of alanine metabolism (HP:0010916)2.37768084
71Hyperalaninemia (HP:0003348)2.37768084
72Gout (HP:0001997)2.36739762
73Increased serum pyruvate (HP:0003542)2.36199593
74Spastic diplegia (HP:0001264)2.36040522
75Irritability (HP:0000737)2.33647913
76Cerebral edema (HP:0002181)2.32278675
77Gingival bleeding (HP:0000225)2.32129708
78Esophageal varix (HP:0002040)2.27997703
79Cardiovascular calcification (HP:0011915)2.25571651
80Mitral stenosis (HP:0001718)2.22691338
81Pancreatitis (HP:0001733)2.22494775
82Hydroxyprolinuria (HP:0003080)2.21806852
83Abnormality of proline metabolism (HP:0010907)2.21806852
84Neonatal onset (HP:0003623)2.21197126
85Late onset (HP:0003584)2.20906946
86Menorrhagia (HP:0000132)2.18540102
87Abnormality of alkaline phosphatase activity (HP:0004379)2.17259609
88Pigmentary retinal degeneration (HP:0001146)2.15569573
89Recurrent gram-negative bacterial infections (HP:0005420)2.15132703
90Abnormality of carpal bone ossification (HP:0006257)2.14704845
91Abnormal enzyme/coenzyme activity (HP:0012379)2.14456782
92Epistaxis (HP:0000421)2.13791064
93Thrombophlebitis (HP:0004418)2.13109984
94Sensorimotor neuropathy (HP:0007141)2.12050194
95* Amyloidosis (HP:0011034)2.10592776
96Enlarged kidneys (HP:0000105)2.08670940
97Vomiting (HP:0002013)2.07881892
98Brushfield spots (HP:0001088)2.07554500
99Abnormality of the gallbladder (HP:0005264)2.06983686
100Hemorrhage of the eye (HP:0011885)2.06153779
101Hyperinsulinemic hypoglycemia (HP:0000825)2.05466577
102Generalized aminoaciduria (HP:0002909)2.03589308
103Abnormality of transition element cation homeostasis (HP:0011030)1.98607096
104Reticulocytosis (HP:0001923)1.97638905
105Abnormality of glycolysis (HP:0004366)1.97019760
106Abnormality of iron homeostasis (HP:0011031)1.96228534
107Hepatoblastoma (HP:0002884)1.95259058
108Opisthotonus (HP:0002179)1.94882768
109Abnormal tarsal ossification (HP:0008369)1.94102582
110Elevated alkaline phosphatase (HP:0003155)1.92501199
111Megaloblastic anemia (HP:0001889)1.91268896
112Rickets (HP:0002748)1.90813596
113Abnormal cartilage morphology (HP:0002763)1.86584880
114Abnormality of vitamin metabolism (HP:0100508)1.85574665
115Abnormality of vitamin B metabolism (HP:0004340)1.84940425
116Pancreatic islet-cell hyperplasia (HP:0004510)1.84431644
117Abnormality of the vitamin B12 metabolism (HP:0004341)1.84419566
118Widely patent fontanelles and sutures (HP:0004492)1.82711382
119Abnormality of urine glucose concentration (HP:0011016)1.81154618
120Glycosuria (HP:0003076)1.81154618
121Hypophosphatemic rickets (HP:0004912)1.80258464
122Nephritis (HP:0000123)1.79204997
123Confusion (HP:0001289)1.79021460
124Elevated hepatic transaminases (HP:0002910)1.78784237
125Renal cortical cysts (HP:0000803)1.76262828
126Proximal tubulopathy (HP:0000114)1.76161215
127Hyperphosphaturia (HP:0003109)1.74759974
128Gonadal dysgenesis (HP:0000133)1.70909344
129Abnormality of the nasal septum (HP:0000419)1.69914446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.91580081
2ERN14.59429315
3FGFR44.43363898
4SIK14.20240405
5TAOK32.93341471
6TESK22.91690189
7ACVR1B2.75448967
8INSRR2.73403175
9MST1R2.73283415
10ERBB42.68981445
11CDK192.45528376
12LMTK22.39830096
13PKN22.18931586
14MAP2K42.16817033
15FRK2.08176899
16PDK210.7121205
17MAPK111.95230350
18MAP3K121.90015331
19TRIB31.86576820
20PTK61.83348036
21FLT31.78028454
22GRK61.77716245
23TYK21.71231835
24LATS11.61751488
25PIK3CG1.58806669
26DAPK21.46518064
27KDR1.39146518
28MAP3K101.38777948
29ABL21.37859093
30NEK91.29612787
31WNK41.23278164
32WNK31.20189171
33PRKAA21.18053150
34MAP3K71.15911438
35JAK21.15580371
36TBK11.15157070
37MET1.12463346
38PDGFRA1.11912820
39MAP3K111.11512741
40NEK21.10203677
41MAP2K31.09982841
42ERBB21.09003129
43MAP3K31.04538103
44EPHB11.04245967
45RIPK11.01942673
46FGFR21.01334224
47MUSK0.96881277
48MAPK40.93819367
49FGFR10.93574860
50JAK10.89017389
51PINK10.88712473
52PRKCZ0.84681698
53NTRK30.82911409
54MAP2K60.80683346
55CDK60.79249838
56FGR0.79002737
57PTK20.78968327
58DYRK1B0.78243000
59PRKACG0.78084946
60MAP3K140.76435143
61STK30.75667230
62STK38L0.73494441
63EPHA30.73411000
64CSK0.72841721
65CAMK2G0.71642850
66MAP2K20.71495292
67MAPK120.71106274
68TIE10.70837250
69TYRO30.68397677
70GSK3A0.66732144
71MATK0.65882753
72MAPK150.65201778
73PRKAA10.64767056
74EIF2AK30.64229673
75MYLK0.61105475
76PRKACB0.60390254
77MAP2K10.59902527
78PDPK10.58728480
79EPHA20.58414058
80TGFBR20.55696109
81IRAK30.55649084
82CAMK1D0.53587731
83PBK0.52895264
84AKT30.51298638
85CSNK1D0.51175553
86IKBKE0.50582081
87EIF2AK10.50178440
88SGK30.49820109
89CSNK1E0.49716495
90TAOK20.49484113
91PRKG10.49252687
92PRKCQ0.48821794
93GRK10.48643956
94PRKG20.47969720
95TRIM280.47161162
96CSNK2A20.46945117
97NLK0.45304090
98MAPK70.43552612
99CSF1R0.43116095
100MAP3K50.43030892
101ICK0.42908457
102STK40.42854385
103PRKCB0.42691116
104TNIK0.42580641
105FGFR30.42498252
106MAP3K20.42429124
107NEK60.42157847
108MAP3K10.41986597
109CSNK2A10.40792185
110CDK40.40644166
111EPHB20.40332686
112RPS6KB10.40072749
113BMX0.37540620
114IGF1R0.37152845
115MAP3K60.37078688
116RET0.36662950
117PRKCE0.34976978
118PDK10.34795981
119NEK10.34708453
120CSNK1G10.34360265
121CSNK1A10.34110162
122MAPKAPK30.32793509
123PDGFRB0.32761180
124EGFR0.32405458
125EPHA40.32195173
126DDR20.31734275
127MTOR0.31187615
128PRKACA0.30993236
129SRC0.30561139
130MAP3K130.29963605
131PRKD30.29259569
132PRKCG0.29256771
133PRKCA0.28768202
134PAK30.27907469
135NUAK10.27865354
136CDK70.26956332
137CAMK40.26869745
138KSR20.25517103
139OXSR10.25051197
140STK160.24112001
141MAP4K10.24007455
142CAMK2D0.21745492
143SGK20.21705408
144WEE10.21270606
145AKT20.20076939
146PIK3CA0.18767760
147PKN10.18287297
148TAOK10.16592980
149CLK10.14889045
150PRKCI0.14340605
151NME10.13457986

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32577949
2Nitrogen metabolism_Homo sapiens_hsa009103.57480648
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30251212
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29946073
5Arginine biosynthesis_Homo sapiens_hsa002203.10994131
6Complement and coagulation cascades_Homo sapiens_hsa046102.74139307
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65277065
8Tryptophan metabolism_Homo sapiens_hsa003802.64552454
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62192151
10Fatty acid degradation_Homo sapiens_hsa000712.50665041
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49923343
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30374735
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18532119
14Butanoate metabolism_Homo sapiens_hsa006502.10289659
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08726290
16Peroxisome_Homo sapiens_hsa041462.03163120
17Histidine metabolism_Homo sapiens_hsa003401.96655262
18* PPAR signaling pathway_Homo sapiens_hsa033201.88764557
19Chemical carcinogenesis_Homo sapiens_hsa052041.88598563
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86163986
21Propanoate metabolism_Homo sapiens_hsa006401.83294636
22Fatty acid metabolism_Homo sapiens_hsa012121.82383586
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.80017034
24Caffeine metabolism_Homo sapiens_hsa002321.73368323
25Staphylococcus aureus infection_Homo sapiens_hsa051501.70680900
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.69779129
27beta-Alanine metabolism_Homo sapiens_hsa004101.68325455
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67946041
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64293295
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64115026
31Retinol metabolism_Homo sapiens_hsa008301.61636639
32Bile secretion_Homo sapiens_hsa049761.58118498
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56650599
34* Fat digestion and absorption_Homo sapiens_hsa049751.56442163
35Selenocompound metabolism_Homo sapiens_hsa004501.54049686
36Phenylalanine metabolism_Homo sapiens_hsa003601.52537158
37Sulfur metabolism_Homo sapiens_hsa009201.43448706
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42649540
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40486437
40Pyruvate metabolism_Homo sapiens_hsa006201.39081837
41Tyrosine metabolism_Homo sapiens_hsa003501.38085837
42Folate biosynthesis_Homo sapiens_hsa007901.36577654
43Fatty acid elongation_Homo sapiens_hsa000621.33363395
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.29633959
45Steroid biosynthesis_Homo sapiens_hsa001001.23216984
46Biosynthesis of amino acids_Homo sapiens_hsa012301.22267841
47ABC transporters_Homo sapiens_hsa020101.19150713
48Other glycan degradation_Homo sapiens_hsa005111.18288290
49Carbon metabolism_Homo sapiens_hsa012001.16504516
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.14767280
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.06546411
52Arginine and proline metabolism_Homo sapiens_hsa003301.03837686
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01403174
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00735686
55* Vitamin digestion and absorption_Homo sapiens_hsa049770.97408258
56Sulfur relay system_Homo sapiens_hsa041220.94863521
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93586441
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93335216
59Vitamin B6 metabolism_Homo sapiens_hsa007500.88270420
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79766620
61Lysine degradation_Homo sapiens_hsa003100.78919827
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77068297
63Glycerolipid metabolism_Homo sapiens_hsa005610.76652753
64Glutathione metabolism_Homo sapiens_hsa004800.74062153
65One carbon pool by folate_Homo sapiens_hsa006700.67635487
66Sphingolipid metabolism_Homo sapiens_hsa006000.67156433
67Pentose phosphate pathway_Homo sapiens_hsa000300.65051062
68Fatty acid biosynthesis_Homo sapiens_hsa000610.54615616
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52921541
70Galactose metabolism_Homo sapiens_hsa000520.50668114
71Metabolic pathways_Homo sapiens_hsa011000.47060840
72Fructose and mannose metabolism_Homo sapiens_hsa000510.41166913
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34180511
74N-Glycan biosynthesis_Homo sapiens_hsa005100.29854190
75Prion diseases_Homo sapiens_hsa050200.26583029
76Linoleic acid metabolism_Homo sapiens_hsa005910.26376692
77Insulin resistance_Homo sapiens_hsa049310.22728190
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.22212109
79Renin-angiotensin system_Homo sapiens_hsa046140.21426599
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.20201385
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19034664
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17586691
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13115130
84Glucagon signaling pathway_Homo sapiens_hsa049220.07408653
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05829941
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05108348
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02082582
88AMPK signaling pathway_Homo sapiens_hsa041520.01479229
89Mineral absorption_Homo sapiens_hsa049780.00192590
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.2485016
91Ether lipid metabolism_Homo sapiens_hsa00565-0.2073140
92Regulation of autophagy_Homo sapiens_hsa04140-0.2045084
93Bladder cancer_Homo sapiens_hsa05219-0.2018556
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1945605
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1896530
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1849180
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1734430
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1477003
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1476030
100Hepatitis C_Homo sapiens_hsa05160-0.1475999
101Tight junction_Homo sapiens_hsa04530-0.1369002
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1350088
103Protein digestion and absorption_Homo sapiens_hsa04974-0.1248198
104Lysosome_Homo sapiens_hsa04142-0.1198353
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1127767
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1117496
107TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1066263
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0864345
109Pertussis_Homo sapiens_hsa05133-0.0672447
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0351006
111Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0207522

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