APOA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63949133
2L-phenylalanine catabolic process (GO:0006559)7.63949133
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.32075181
4L-phenylalanine metabolic process (GO:0006558)7.32075181
5aromatic amino acid family catabolic process (GO:0009074)6.80130873
6* protein-lipid complex assembly (GO:0065005)6.49184722
7* triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.23574562
8tryptophan catabolic process (GO:0006569)6.05546386
9indole-containing compound catabolic process (GO:0042436)6.05546386
10indolalkylamine catabolic process (GO:0046218)6.05546386
11kynurenine metabolic process (GO:0070189)5.96614580
12bile acid biosynthetic process (GO:0006699)5.88107634
13positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.86393319
14glyoxylate metabolic process (GO:0046487)5.79370454
15negative regulation of fibrinolysis (GO:0051918)5.77803549
16alpha-linolenic acid metabolic process (GO:0036109)5.75578005
17tryptophan metabolic process (GO:0006568)5.72217384
18intestinal cholesterol absorption (GO:0030299)5.67906148
19urea cycle (GO:0000050)5.67568393
20urea metabolic process (GO:0019627)5.67568393
21* high-density lipoprotein particle remodeling (GO:0034375)5.59444969
22regulation of fibrinolysis (GO:0051917)5.52604131
23regulation of plasminogen activation (GO:0010755)5.44925723
24protein carboxylation (GO:0018214)5.44659086
25peptidyl-glutamic acid carboxylation (GO:0017187)5.44659086
26sulfur amino acid catabolic process (GO:0000098)5.42437677
27cysteine metabolic process (GO:0006534)5.39012150
28* protein-lipid complex subunit organization (GO:0071825)5.33146468
29nitrogen cycle metabolic process (GO:0071941)5.21971830
30serine family amino acid catabolic process (GO:0009071)5.18754085
31regulation of protein activation cascade (GO:2000257)5.13405716
32bile acid metabolic process (GO:0008206)5.09728277
33complement activation, alternative pathway (GO:0006957)5.08999064
34* low-density lipoprotein particle remodeling (GO:0034374)5.03522719
35regulation of triglyceride catabolic process (GO:0010896)5.01825098
36aromatic amino acid family metabolic process (GO:0009072)4.95573554
37tyrosine metabolic process (GO:0006570)4.87253170
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85290595
39* reverse cholesterol transport (GO:0043691)4.82500682
40* plasma lipoprotein particle remodeling (GO:0034369)4.82438120
41* protein-lipid complex remodeling (GO:0034368)4.82438120
42* macromolecular complex remodeling (GO:0034367)4.82438120
43acylglycerol homeostasis (GO:0055090)4.78648520
44triglyceride homeostasis (GO:0070328)4.78648520
45regulation of complement activation (GO:0030449)4.74924817
46homocysteine metabolic process (GO:0050667)4.72720776
47negative regulation of protein activation cascade (GO:2000258)4.68520971
48alpha-amino acid catabolic process (GO:1901606)4.67188390
49amino-acid betaine metabolic process (GO:0006577)4.65630035
50cellular ketone body metabolic process (GO:0046950)4.62615647
51negative regulation of blood coagulation (GO:0030195)4.59595808
52negative regulation of hemostasis (GO:1900047)4.59595808
53* regulation of cholesterol esterification (GO:0010872)4.57240058
54* negative regulation of lipase activity (GO:0060192)4.55962177
55lysine catabolic process (GO:0006554)4.55744877
56lysine metabolic process (GO:0006553)4.55744877
57glycine metabolic process (GO:0006544)4.45896058
58epoxygenase P450 pathway (GO:0019373)4.45491721
59* phospholipid efflux (GO:0033700)4.41520944
60bile acid and bile salt transport (GO:0015721)4.41032962
61* plasma lipoprotein particle clearance (GO:0034381)4.37450489
62regulation of apoptotic cell clearance (GO:2000425)4.37444537
63imidazole-containing compound metabolic process (GO:0052803)4.37175575
64* negative regulation of cholesterol transport (GO:0032375)4.35558874
65* negative regulation of sterol transport (GO:0032372)4.35558874
66coenzyme catabolic process (GO:0009109)4.32292166
67indolalkylamine metabolic process (GO:0006586)4.30396366
68cellular amino acid catabolic process (GO:0009063)4.29920772
69glutamate metabolic process (GO:0006536)4.27871435
70cellular glucuronidation (GO:0052695)4.26886293
71positive regulation of hemostasis (GO:1900048)4.24815568
72positive regulation of blood coagulation (GO:0030194)4.24815568
73negative regulation of coagulation (GO:0050819)4.22171364
74amine catabolic process (GO:0009310)4.21638932
75cellular biogenic amine catabolic process (GO:0042402)4.21638932
76* cholesterol efflux (GO:0033344)4.20707953
77serine family amino acid metabolic process (GO:0009069)4.20553699
78* lipoprotein metabolic process (GO:0042157)4.16810132
79regulation of humoral immune response (GO:0002920)4.15581122
80benzene-containing compound metabolic process (GO:0042537)4.12948502
81ethanol oxidation (GO:0006069)4.09426896
82acute-phase response (GO:0006953)4.08351072
83aldehyde catabolic process (GO:0046185)4.07986455
84cellular modified amino acid catabolic process (GO:0042219)4.07948968
85arginine metabolic process (GO:0006525)4.07857621
86drug catabolic process (GO:0042737)4.07105541
87dicarboxylic acid biosynthetic process (GO:0043650)4.07066978
88serine family amino acid biosynthetic process (GO:0009070)4.07058448
89fibrinolysis (GO:0042730)4.06987466
90* cholesterol transport (GO:0030301)4.06040996
91* sterol transport (GO:0015918)4.06040996
92negative regulation of wound healing (GO:0061045)4.04764149
93ketone body metabolic process (GO:1902224)4.00609890
94positive regulation of triglyceride lipase activity (GO:0061365)3.99486705
95positive regulation of lipoprotein lipase activity (GO:0051006)3.99486705
96exogenous drug catabolic process (GO:0042738)3.98212730
97very-low-density lipoprotein particle assembly (GO:0034379)3.96761926
98blood coagulation, intrinsic pathway (GO:0007597)3.92456839
99* plasma lipoprotein particle assembly (GO:0034377)3.89547532
100proline metabolic process (GO:0006560)3.89325450
101positive regulation of coagulation (GO:0050820)3.88527890
102phospholipid homeostasis (GO:0055091)3.85982559
103cofactor catabolic process (GO:0051187)3.82357379
104positive regulation of fatty acid biosynthetic process (GO:0045723)3.80274422
105omega-hydroxylase P450 pathway (GO:0097267)3.78880369
106glucuronate metabolic process (GO:0019585)3.78509644
107uronic acid metabolic process (GO:0006063)3.78509644
108organic acid catabolic process (GO:0016054)3.77930053
109carboxylic acid catabolic process (GO:0046395)3.77930053
110regulation of heterotypic cell-cell adhesion (GO:0034114)3.76170586
111short-chain fatty acid metabolic process (GO:0046459)3.75852945
112* cholesterol homeostasis (GO:0042632)3.73626949
113* sterol homeostasis (GO:0055092)3.67255874
114regulation of bile acid biosynthetic process (GO:0070857)3.66869525
115protein activation cascade (GO:0072376)3.66019692
116acetyl-CoA metabolic process (GO:0006084)3.63515472
117regulation of cholesterol homeostasis (GO:2000188)3.63477245
118* plasma lipoprotein particle organization (GO:0071827)3.63006809
119regulation of lipoprotein particle clearance (GO:0010984)3.62209289
120complement activation, classical pathway (GO:0006958)3.62116043
121ethanol metabolic process (GO:0006067)3.60851919
122complement activation (GO:0006956)3.60567022
123* positive regulation of lipid catabolic process (GO:0050996)3.58683201
124NAD biosynthetic process (GO:0009435)3.58328046
125flavonoid metabolic process (GO:0009812)3.57176965
126nicotinamide nucleotide biosynthetic process (GO:0019359)3.56367399
127pyridine nucleotide biosynthetic process (GO:0019363)3.56367399
128opsonization (GO:0008228)3.53867890
129intestinal absorption (GO:0050892)3.53175589
130positive regulation of fatty acid beta-oxidation (GO:0032000)3.52457505
131drug metabolic process (GO:0017144)3.45015341
132negative regulation of complement activation (GO:0045916)3.44732286
133negative regulation of fatty acid biosynthetic process (GO:0045717)3.41771260
134heme transport (GO:0015886)3.38972066
135* lipid homeostasis (GO:0055088)3.35215270
136* positive regulation of steroid metabolic process (GO:0045940)3.29720244
137cytolysis (GO:0019835)3.25879593
138peptidyl-glutamic acid modification (GO:0018200)3.23924189
139regulation of cholesterol biosynthetic process (GO:0045540)3.19623604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.44756119
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22938831
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.95203563
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52127711
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31113435
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18864445
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98748055
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03929328
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01554172
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07893435
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01521834
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9562769
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97572195
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77028545
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73118035
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58662131
17CLOCK_20551151_ChIP-Seq_293T_Human1.58044092
18HTT_18923047_ChIP-ChIP_STHdh_Human1.56179341
19TCF4_18268006_ChIP-ChIP_LS174T_Human1.49917327
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46401684
21GATA1_22025678_ChIP-Seq_K562_Human1.44309908
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40229166
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29059648
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19828014
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17483647
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14529544
27AR_21909140_ChIP-Seq_LNCAP_Human1.12687680
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11266857
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05073172
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02300752
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01394341
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98533144
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93744815
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92433761
35SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90602461
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89409728
37POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86396854
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85311385
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85021862
40AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84018471
41IRF8_22096565_ChIP-ChIP_GC-B_Human0.83440348
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81750533
43GATA4_25053715_ChIP-Seq_YYC3_Human0.80978048
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79727620
45ZNF263_19887448_ChIP-Seq_K562_Human0.78136850
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77253743
47SOX2_20726797_ChIP-Seq_SW620_Human0.77002285
48CDX2_19796622_ChIP-Seq_MESCs_Mouse0.76748717
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76226847
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75991379
51NFE2_27457419_Chip-Seq_LIVER_Mouse0.75598703
52RARA_24833708_ChIP-Seq_LIVER_Mouse0.74917678
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74712933
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74136932
55SOX17_20123909_ChIP-Seq_XEN_Mouse0.71881315
56TRIM28_21343339_ChIP-Seq_HEK293_Human0.71606514
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70824390
58* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.70026979
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69999462
60PCGF2_27294783_Chip-Seq_NPCs_Mouse0.69682721
61TP53_16413492_ChIP-PET_HCT116_Human0.69275293
62SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67181024
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66584609
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65124896
65CTNNB1_20460455_ChIP-Seq_HCT116_Human0.63955739
66RARB_24833708_ChIP-Seq_LIVER_Mouse0.63859134
67ESR2_21235772_ChIP-Seq_MCF-7_Human0.63855713
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.63844056
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63192891
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62434698
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62334694
72NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62072372
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62072372
74RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61788664
75NFIB_24661679_ChIP-Seq_LUNG_Mouse0.61450582
76* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59835172
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.59418763
78* ZFX_18555785_Chip-Seq_ESCs_Mouse0.59285608
79* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.58394722
80CEBPB_22108803_ChIP-Seq_LS180_Human0.57903240
81LXR_22292898_ChIP-Seq_THP-1_Human0.56425960
82GATA3_24758297_ChIP-Seq_MCF-7_Human0.55938223
83SOX2_21211035_ChIP-Seq_LN229_Human0.55463347
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.55014256
85* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.54567566
86* OCT4_18555785_Chip-Seq_ESCs_Mouse0.54198245
87EGR1_19032775_ChIP-ChIP_M12_Human0.53357131
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53249106
89RAC3_21632823_ChIP-Seq_H3396_Human0.52855499
90* EOMES_21245162_ChIP-Seq_HESCs_Human0.52240390
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.52082703
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.52023474
93FOXA1_25552417_ChIP-Seq_VCAP_Human0.51938360
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51545097
95MYC_19915707_ChIP-ChIP_AK7_Human0.51524218
96AR_20517297_ChIP-Seq_VCAP_Human0.51399514
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.51160374
98SOX11_22085726_ChIP-Seq_ESNs_Mouse0.50386598
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.49962989
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49911226
101CSB_26484114_Chip-Seq_FIBROBLAST_Human0.49634079
102FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49426533
103JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.49415743
104ESET_19884257_ChIP-Seq_ESCs_Mouse0.48587719
105CBP_21632823_ChIP-Seq_H3396_Human0.47687588
106P53_21459846_ChIP-Seq_SAOS-2_Human0.47501335
107GATA1_19941826_ChIP-Seq_K562_Human0.46858850
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46605927
109STAT1_17558387_ChIP-Seq_HELA_Human0.46531488
110PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46360333
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.45364282
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43643212
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42327984
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.41575875
115GATA2_19941826_ChIP-Seq_K562_Human0.41503630
116TAF2_19829295_ChIP-Seq_ESCs_Human0.41447759
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40513328
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.40342806
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.40288447
120* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40143524
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40137899
122TAF15_26573619_Chip-Seq_HEK293_Human0.38984824
123GATA6_25053715_ChIP-Seq_YYC3_Human0.38629189
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.38563244
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38379992
126BCAT_22108803_ChIP-Seq_LS180_Human0.37597368
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.37201143
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36904782
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36400295
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.36377135
131CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34728897
132SPI1_26923725_Chip-Seq_HPCs_Mouse0.34501948
133NCOR_22424771_ChIP-Seq_293T_Human0.33974866
134SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33601234
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33352905
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.33115520
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.33073451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.43144764
2MP0005360_urolithiasis7.45762978
3MP0005085_abnormal_gallbladder_physiolo6.38732073
4MP0005365_abnormal_bile_salt6.21436265
5MP0008875_abnormal_xenobiotic_pharmacok5.21463606
6MP0003806_abnormal_nucleotide_metabolis4.24935053
7MP0003252_abnormal_bile_duct3.85284760
8* MP0010329_abnormal_lipoprotein_level3.55719258
9MP0009840_abnormal_foam_cell3.51398970
10MP0005083_abnormal_biliary_tract3.11329291
11MP0003122_maternal_imprinting2.97356721
12MP0003195_calcinosis2.84484103
13MP0005332_abnormal_amino_acid2.76098842
14MP0001666_abnormal_nutrient_absorption2.56559345
15MP0003191_abnormal_cellular_cholesterol2.40190307
16MP0000609_abnormal_liver_physiology2.18215211
17MP0004019_abnormal_vitamin_homeostasis2.15553634
18* MP0002118_abnormal_lipid_homeostasis2.10142327
19MP0002138_abnormal_hepatobiliary_system1.94096654
20MP0003868_abnormal_feces_composition1.87157475
21MP0005319_abnormal_enzyme/_coenzyme1.82257988
22MP0003123_paternal_imprinting1.69299743
23MP0001764_abnormal_homeostasis1.68722936
24MP0009697_abnormal_copulation1.65286825
25MP0005451_abnormal_body_composition1.58494669
26MP0005584_abnormal_enzyme/coenzyme_acti1.58472254
27MP0003011_delayed_dark_adaptation1.46930158
28MP0000566_synostosis1.43797211
29MP0001915_intracranial_hemorrhage1.43539136
30MP0003656_abnormal_erythrocyte_physiolo1.30648728
31MP0003186_abnormal_redox_activity1.28503917
32MP0002089_abnormal_postnatal_growth/wei1.27523643
33MP0009643_abnormal_urine_homeostasis1.22705409
34MP0000598_abnormal_liver_morphology1.18054146
35MP0004272_abnormal_basement_membrane1.15118308
36MP0003705_abnormal_hypodermis_morpholog1.12964895
37MP0005647_abnormal_sex_gland1.10585453
38MP0009764_decreased_sensitivity_to1.05568698
39MP0003172_abnormal_lysosome_physiology1.05254682
40MP0009763_increased_sensitivity_to1.01991888
41MP0004264_abnormal_extraembryonic_tissu1.00959141
42MP0002254_reproductive_system_inflammat0.99372889
43MP0010368_abnormal_lymphatic_system0.94288604
44MP0001986_abnormal_taste_sensitivity0.92773006
45MP0005636_abnormal_mineral_homeostasis0.92735160
46MP0008469_abnormal_protein_level0.87966524
47* MP0009642_abnormal_blood_homeostasis0.86947929
48MP0006054_spinal_hemorrhage0.86924403
49MP0006036_abnormal_mitochondrial_physio0.84609477
50MP0005408_hypopigmentation0.84499689
51MP0003567_abnormal_fetal_cardiomyocyte0.83104989
52MP0005376_homeostasis/metabolism_phenot0.80894679
53MP0009765_abnormal_xenobiotic_induced0.78589482
54MP0003121_genomic_imprinting0.78254453
55* MP0002078_abnormal_glucose_homeostasis0.76680701
56MP0002876_abnormal_thyroid_physiology0.76206241
57MP0005084_abnormal_gallbladder_morpholo0.75605654
58* MP0000604_amyloidosis0.72825683
59MP0002971_abnormal_brown_adipose0.71990130
60MP0005670_abnormal_white_adipose0.71976424
61MP0005334_abnormal_fat_pad0.70135808
62MP0003690_abnormal_glial_cell0.69071590
63MP0009053_abnormal_anal_canal0.68564246
64MP0005220_abnormal_exocrine_pancreas0.68220781
65MP0003329_amyloid_beta_deposits0.67638719
66MP0004130_abnormal_muscle_cell0.67390679
67MP0005409_darkened_coat_color0.67383572
68MP0002938_white_spotting0.66614508
69MP0001661_extended_life_span0.65905703
70MP0005535_abnormal_body_temperature0.65825229
71MP0005266_abnormal_metabolism0.64635453
72MP0000639_abnormal_adrenal_gland0.63751077
73MP0003879_abnormal_hair_cell0.63424443
74MP0003315_abnormal_perineum_morphology0.61555795
75MP0001756_abnormal_urination0.59818416
76MP0006035_abnormal_mitochondrial_morpho0.57396680
77MP0005448_abnormal_energy_balance0.57029641
78MP0009384_cardiac_valve_regurgitation0.56818635
79MP0001324_abnormal_eye_pigmentation0.55685895
80MP0005464_abnormal_platelet_physiology0.55507794
81MP0003950_abnormal_plasma_membrane0.55387317
82MP0005023_abnormal_wound_healing0.55362407
83MP0005410_abnormal_fertilization0.55116184
84MP0002822_catalepsy0.51850352
85MP0002909_abnormal_adrenal_gland0.51452979
86MP0003941_abnormal_skin_development0.51168798
87MP0003632_abnormal_nervous_system0.51048215
88MP0005257_abnormal_intraocular_pressure0.48986270
89MP0005395_other_phenotype0.48701015
90MP0000920_abnormal_myelination0.48397402
91MP0005379_endocrine/exocrine_gland_phen0.48063521
92MP0003890_abnormal_embryonic-extraembry0.47468866
93MP0008874_decreased_physiological_sensi0.47149823
94MP0003718_maternal_effect0.46822487
95MP0005551_abnormal_eye_electrophysiolog0.46810618
96MP0003638_abnormal_response/metabolism_0.46727687
97MP0003878_abnormal_ear_physiology0.46042148
98MP0005377_hearing/vestibular/ear_phenot0.46042148
99MP0008873_increased_physiological_sensi0.45847314
100MP0003943_abnormal_hepatobiliary_system0.45783882
101MP0002136_abnormal_kidney_physiology0.44673644
102MP0009780_abnormal_chondrocyte_physiolo0.44254467
103MP0002837_dystrophic_cardiac_calcinosis0.43849125
104MP0004782_abnormal_surfactant_physiolog0.41956397
105MP0003699_abnormal_female_reproductive0.41736001
106MP0002928_abnormal_bile_duct0.41719265
107MP0002282_abnormal_trachea_morphology0.41512284
108MP0003075_altered_response_to0.41487167
109MP0001270_distended_abdomen0.41352335
110MP0005248_abnormal_Harderian_gland0.40692935
111MP0005187_abnormal_penis_morphology0.40679088
112MP0003436_decreased_susceptibility_to0.40431785
113MP0008872_abnormal_physiological_respon0.39925382
114* MP0003953_abnormal_hormone_level0.39497116
115MP0009672_abnormal_birth_weight0.38068824
116MP0003724_increased_susceptibility_to0.37601655
117MP0005666_abnormal_adipose_tissue0.35971256
118MP0004883_abnormal_blood_vessel0.35749717
119MP0005166_decreased_susceptibility_to0.34504240
120MP0000249_abnormal_blood_vessel0.34203232
121MP0001243_abnormal_dermal_layer0.34172575
122MP0009115_abnormal_fat_cell0.33705619
123MP0006082_CNS_inflammation0.32833851
124MP0002796_impaired_skin_barrier0.31372805
125MP0000230_abnormal_systemic_arterial0.31173893
126MP0002168_other_aberrant_phenotype0.30921356
127MP0002970_abnormal_white_adipose0.30902705
128MP0001853_heart_inflammation0.30418227
129MP0004381_abnormal_hair_follicle0.29118113
130MP0001845_abnormal_inflammatory_respons0.27662309
131MP0000579_abnormal_nail_morphology0.27532785
132MP0001881_abnormal_mammary_gland0.27193137
133MP0005164_abnormal_response_to0.26859963
134MP0002090_abnormal_vision0.24997078
135MP0005167_abnormal_blood-brain_barrier0.23694378
136MP0002132_abnormal_respiratory_system0.22501510
137MP0005058_abnormal_lysosome_morphology0.22492774

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.49964846
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47151563
3Intrahepatic cholestasis (HP:0001406)7.13697105
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65664007
5Hypobetalipoproteinemia (HP:0003563)6.64698353
6Prolonged partial thromboplastin time (HP:0003645)6.57184198
7Xanthomatosis (HP:0000991)6.35909499
8Hyperlipoproteinemia (HP:0010980)5.74963714
9Hypolipoproteinemia (HP:0010981)4.96817351
10Complement deficiency (HP:0004431)4.91295387
11Joint hemorrhage (HP:0005261)4.87083078
12Hyperammonemia (HP:0001987)4.61858788
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.53200765
14Epidermoid cyst (HP:0200040)4.47360757
15Abnormality of the common coagulation pathway (HP:0010990)4.43079723
16Hyperglycinemia (HP:0002154)4.39025619
17Hypoalphalipoproteinemia (HP:0003233)4.33963239
18Abnormality of methionine metabolism (HP:0010901)4.33383673
19Ketosis (HP:0001946)4.28406678
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.24541606
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13184698
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09107633
23Fat malabsorption (HP:0002630)4.02947196
24Hypoglycemic coma (HP:0001325)3.96431462
25Hyperglycinuria (HP:0003108)3.93065417
26Abnormality of serine family amino acid metabolism (HP:0010894)3.91952854
27Abnormality of glycine metabolism (HP:0010895)3.91952854
28Abnormality of pyrimidine metabolism (HP:0004353)3.84023850
29Abnormality of the intrinsic pathway (HP:0010989)3.74324241
30Hypercholesterolemia (HP:0003124)3.70700020
31Conjugated hyperbilirubinemia (HP:0002908)3.61119717
32Abnormality of complement system (HP:0005339)3.57996655
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39804388
34Hyperbilirubinemia (HP:0002904)3.39007116
35Abnormality of fatty-acid metabolism (HP:0004359)3.38361595
36Delayed CNS myelination (HP:0002188)3.10829668
37Abnormality of serum amino acid levels (HP:0003112)3.05833200
38Abnormality of nucleobase metabolism (HP:0010932)3.04374387
39Ketoacidosis (HP:0001993)3.03790470
40Osteomalacia (HP:0002749)3.02655640
41Spontaneous abortion (HP:0005268)3.01029856
42Steatorrhea (HP:0002570)3.00806757
43Hypochromic microcytic anemia (HP:0004840)2.98621801
44Hepatocellular carcinoma (HP:0001402)2.97507141
45Myocardial infarction (HP:0001658)2.88711603
46Metabolic acidosis (HP:0001942)2.79960624
47Skin nodule (HP:0200036)2.75587101
48Abnormality of purine metabolism (HP:0004352)2.64549656
49Acanthocytosis (HP:0001927)2.64245200
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63265175
51Dicarboxylic aciduria (HP:0003215)2.63265175
52Lethargy (HP:0001254)2.61702453
53Vascular calcification (HP:0004934)2.61117190
54Purpura (HP:0000979)2.56958863
55Abnormality of carpal bone ossification (HP:0006257)2.56499953
56Hypoglycemic seizures (HP:0002173)2.54701501
57Systemic lupus erythematosus (HP:0002725)2.52313482
58Abnormal gallbladder morphology (HP:0012437)2.51004399
59Spastic diplegia (HP:0001264)2.45664300
60Abnormal tarsal ossification (HP:0008369)2.45353851
61Abnormal gallbladder physiology (HP:0012438)2.45170664
62Cholecystitis (HP:0001082)2.45170664
63Cholelithiasis (HP:0001081)2.44816774
64Cerebral edema (HP:0002181)2.44036818
65Glomerulonephritis (HP:0000099)2.42635701
66Mitral stenosis (HP:0001718)2.40419979
67Pancreatic islet-cell hyperplasia (HP:0004510)2.39866362
68Amyloidosis (HP:0011034)2.39468998
69Retinal atrophy (HP:0001105)2.37723660
70Gout (HP:0001997)2.35254674
71Irritability (HP:0000737)2.34509231
72Malnutrition (HP:0004395)2.31547022
73Cardiovascular calcification (HP:0011915)2.31501223
74Neonatal onset (HP:0003623)2.29368125
75Broad alveolar ridges (HP:0000187)2.29068842
76Hepatoblastoma (HP:0002884)2.26950926
77Gingival bleeding (HP:0000225)2.22909374
78Esophageal varix (HP:0002040)2.21348673
79Menorrhagia (HP:0000132)2.19789807
80Late onset (HP:0003584)2.17427685
81Brushfield spots (HP:0001088)2.16894667
82Joint swelling (HP:0001386)2.15232536
83Increased serum pyruvate (HP:0003542)2.15210329
84Pancreatitis (HP:0001733)2.13122603
85Poikilocytosis (HP:0004447)2.10823071
86Arthropathy (HP:0003040)2.09850380
87Enlarged kidneys (HP:0000105)2.09610485
88Thrombophlebitis (HP:0004418)2.09431836
89Abnormal delivery (HP:0001787)2.09405944
90Vomiting (HP:0002013)2.08555757
91Sensorimotor neuropathy (HP:0007141)2.08516201
92Recurrent gram-negative bacterial infections (HP:0005420)2.08492717
93Hyperinsulinemic hypoglycemia (HP:0000825)2.06892198
94Generalized aminoaciduria (HP:0002909)2.05790275
95Opisthotonus (HP:0002179)2.02535892
96Abnormality of the gallbladder (HP:0005264)2.01996787
97Hemorrhage of the eye (HP:0011885)2.00921185
98Diastasis recti (HP:0001540)1.96000932
99Epistaxis (HP:0000421)1.95779979
100Abnormality of the nasal septum (HP:0000419)1.95207246
101Abnormality of iron homeostasis (HP:0011031)1.94352962
102Rickets (HP:0002748)1.94186598
103Potter facies (HP:0002009)1.93078488
104Facial shape deformation (HP:0011334)1.93078488
105Abnormality of glycolysis (HP:0004366)1.92080203
106Abnormality of transition element cation homeostasis (HP:0011030)1.90854349
107Abnormality of the Achilles tendon (HP:0005109)1.90433254
108Abnormal cartilage morphology (HP:0002763)1.88730209
109Abnormality of urine glucose concentration (HP:0011016)1.88200630
110Glycosuria (HP:0003076)1.88200630
111Renal cortical cysts (HP:0000803)1.87244917
112Hypophosphatemic rickets (HP:0004912)1.86821699
113Abnormality of proline metabolism (HP:0010907)1.86696283
114Hydroxyprolinuria (HP:0003080)1.86696283
115Abnormal hand bone ossification (HP:0010660)1.84969919
116Flat acetabular roof (HP:0003180)1.84396561
117Pulmonary embolism (HP:0002204)1.83285934
118Small epiphyses (HP:0010585)1.83046782
119Broad palm (HP:0001169)1.81909508
120Increased serum ferritin (HP:0003281)1.80663926
121Alkalosis (HP:0001948)1.80255218
122Elevated hepatic transaminases (HP:0002910)1.79083835
123Status epilepticus (HP:0002133)1.78077222
124Abnormal ossification of hand bones (HP:0005921)1.77980559
125Reticulocytosis (HP:0001923)1.77132319
126Proximal tubulopathy (HP:0000114)1.74571839
127Abnormal enzyme/coenzyme activity (HP:0012379)1.74554644
128Abnormality of vitamin metabolism (HP:0100508)1.74522060
129Nephritis (HP:0000123)1.73086110
130Bifid scrotum (HP:0000048)1.62859176
131Prenatal maternal abnormality (HP:0002686)1.61933613
132Reduced antithrombin III activity (HP:0001976)1.60424623
133Hyperphosphaturia (HP:0003109)1.59818694
134Vaginal fistula (HP:0004320)1.59806826
135Abnormality of the lumbar spine (HP:0100712)1.55682739
136Pigmentary retinal degeneration (HP:0001146)1.53396586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.38402999
2PDK25.14958877
3SIK14.74134799
4FGFR44.54398178
5ERN14.20108105
6WNK43.06126639
7INSRR2.98599253
8TAOK32.98365849
9ERBB42.54606526
10PKN22.50230505
11AKT32.49753520
12MAP2K42.32369524
13PIK3CA2.31671248
14FGFR12.10658140
15FLT32.09984847
16MST1R2.09375664
17CDK122.04608466
18PIK3CG1.92231243
19PDGFRA1.85375950
20TYRO31.84973451
21TRIB31.82387367
22MAPK111.77779309
23TYK21.70290624
24DAPK21.67883780
25LATS11.56787148
26ABL21.50675961
27PTK61.47484064
28KDR1.41608371
29NEK91.36352935
30FGFR21.33231457
31NTRK31.31128555
32MAP3K21.30252052
33FRK1.28352553
34JAK21.19379369
35ACVR1B1.18865665
36WNK11.17171384
37PINK11.16608972
38NEK11.14528741
39LMTK21.14235879
40MAP2K31.13061337
41MAP3K71.12783928
42PRKAA21.12149510
43GRK61.09980225
44TBK11.05799625
45MAPK40.98933722
46JAK10.97621496
47MAP3K100.97110210
48MAP3K140.94226396
49PRKCZ0.92109707
50MAP3K30.92043064
51ERBB20.90152624
52MAP3K110.88808570
53MET0.85699701
54CSNK1E0.84650944
55CDK60.82473990
56RPS6KB10.82027965
57STK38L0.81711337
58MAPK120.81557423
59MAPK150.80984037
60TIE10.80465621
61EPHB10.79533920
62CDK70.78757776
63PRKACG0.77586124
64EIF2AK10.77070988
65NLK0.76002525
66DYRK1B0.74573295
67CSK0.74537056
68TESK20.74463745
69CAMK1D0.73080951
70BCR0.71053435
71MAP2K60.70516139
72CSNK1D0.68876930
73SIK20.68545987
74GSK3A0.68149170
75CAMK2G0.67848739
76MUSK0.67830885
77FGR0.67361957
78STK390.66143352
79EPHA30.65344782
80PRKAA10.63750517
81TGFBR20.61532416
82SGK10.60889072
83RIPK10.59890046
84CSNK2A20.59841960
85DDR20.59585971
86PTK20.59045119
87SGK30.58662145
88CSF1R0.57154667
89MAPK70.55689169
90PRKG10.55468224
91IRAK30.54438622
92TAOK20.54348150
93EPHA40.54185137
94PRKACB0.52992241
95PDPK10.52483471
96PRKCQ0.52420913
97IKBKE0.52280520
98CSNK2A10.52239511
99CSNK1G10.51961939
100FGFR30.50127008
101MAPKAPK30.47838844
102WNK30.47397836
103MAP3K120.46805951
104GRK10.45440280
105EIF2AK30.45436456
106MAP2K10.45341353
107BRSK10.44784092
108MAP3K50.44537164
109CDK40.43567656
110IGF1R0.43122921
111RET0.42603320
112BRSK20.42213326
113PRKCG0.42013218
114PRKCB0.41656918
115MAP3K130.40695795
116PBK0.40580431
117SGK20.40379196
118MAP3K60.38128621
119CDC42BPA0.37715208
120ICK0.36670455
121MELK0.35792718
122SRC0.35475963
123STK160.35308742
124TRIM280.35056671
125SCYL20.34886074
126EEF2K0.34826354
127MTOR0.34823866
128PDK10.34278688
129CAMK40.33652437
130RPS6KA30.33273384
131CSNK1G20.32643928
132MATK0.32560624
133EGFR0.31071927
134CSNK1G30.30887087
135PRKACA0.30669897
136NEK20.30558867
137SGK2230.30181695
138SGK4940.30181695
139MAPK100.27992279
140MAP3K10.27051984
141EPHA20.27000821
142PRKCA0.26063857
143MAP2K20.25645559
144LATS20.25445201
145PKN10.23849604
146CAMK1G0.21665805
147PAK30.21203028
148PDK30.21183027
149PDK40.21183027
150CSNK1A1L0.20643102
151BMX0.19609610
152IRAK20.19471051

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40575247
2Nitrogen metabolism_Homo sapiens_hsa009103.56987822
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42354555
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33784092
5Arginine biosynthesis_Homo sapiens_hsa002203.05764818
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79780046
7Complement and coagulation cascades_Homo sapiens_hsa046102.70632753
8Tryptophan metabolism_Homo sapiens_hsa003802.66719709
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63663201
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53707700
11Fatty acid degradation_Homo sapiens_hsa000712.50793823
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39309956
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29003059
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17765542
15Butanoate metabolism_Homo sapiens_hsa006502.17571790
16Peroxisome_Homo sapiens_hsa041462.07333478
17Chemical carcinogenesis_Homo sapiens_hsa052042.00432631
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98631891
19Propanoate metabolism_Homo sapiens_hsa006401.94676751
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.93045847
21Histidine metabolism_Homo sapiens_hsa003401.91369066
22Fatty acid metabolism_Homo sapiens_hsa012121.84292795
23* PPAR signaling pathway_Homo sapiens_hsa033201.79993160
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79081458
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73671786
26Retinol metabolism_Homo sapiens_hsa008301.73400672
27Staphylococcus aureus infection_Homo sapiens_hsa051501.73288187
28beta-Alanine metabolism_Homo sapiens_hsa004101.72620977
29Caffeine metabolism_Homo sapiens_hsa002321.70849693
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67942414
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65780374
32Selenocompound metabolism_Homo sapiens_hsa004501.57383384
33Phenylalanine metabolism_Homo sapiens_hsa003601.54971823
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50898962
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50690569
36Bile secretion_Homo sapiens_hsa049761.47966769
37Tyrosine metabolism_Homo sapiens_hsa003501.42397343
38Fatty acid elongation_Homo sapiens_hsa000621.38851096
39Pyruvate metabolism_Homo sapiens_hsa006201.38291848
40Sulfur metabolism_Homo sapiens_hsa009201.35240548
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.31926361
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28058490
43Steroid biosynthesis_Homo sapiens_hsa001001.21778616
44Folate biosynthesis_Homo sapiens_hsa007901.21611229
45Fat digestion and absorption_Homo sapiens_hsa049751.20531256
46Biosynthesis of amino acids_Homo sapiens_hsa012301.20503248
47ABC transporters_Homo sapiens_hsa020101.18220661
48Carbon metabolism_Homo sapiens_hsa012001.14092989
49Other glycan degradation_Homo sapiens_hsa005111.05153161
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02693539
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.00987569
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00455073
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.99315754
54Arginine and proline metabolism_Homo sapiens_hsa003300.98876293
55Sulfur relay system_Homo sapiens_hsa041220.95659699
56Vitamin B6 metabolism_Homo sapiens_hsa007500.89234947
57Vitamin digestion and absorption_Homo sapiens_hsa049770.87185447
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85707822
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82854688
60Lysine degradation_Homo sapiens_hsa003100.81596254
61One carbon pool by folate_Homo sapiens_hsa006700.77032879
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71496461
63Glycerolipid metabolism_Homo sapiens_hsa005610.68494283
64Glutathione metabolism_Homo sapiens_hsa004800.66464380
65Pentose phosphate pathway_Homo sapiens_hsa000300.59718910
66Fatty acid biosynthesis_Homo sapiens_hsa000610.55058990
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47643611
68Metabolic pathways_Homo sapiens_hsa011000.46175621
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43459907
70N-Glycan biosynthesis_Homo sapiens_hsa005100.41160123
71Sphingolipid metabolism_Homo sapiens_hsa006000.32661252
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27080780
73Prion diseases_Homo sapiens_hsa050200.26727436
74Galactose metabolism_Homo sapiens_hsa000520.26573320
75Pertussis_Homo sapiens_hsa051330.26432941
76Fructose and mannose metabolism_Homo sapiens_hsa000510.25022200
77Mineral absorption_Homo sapiens_hsa049780.24391494
78Linoleic acid metabolism_Homo sapiens_hsa005910.24155598
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22354991
80Insulin resistance_Homo sapiens_hsa049310.22099390
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.20673079
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.15591708
83Glucagon signaling pathway_Homo sapiens_hsa049220.08959647
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.03196158
85AMPK signaling pathway_Homo sapiens_hsa041520.01301250
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01287825
87Bladder cancer_Homo sapiens_hsa05219-0.2561330
88Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2467568
89Ether lipid metabolism_Homo sapiens_hsa00565-0.2424313
90Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2376454
91Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2362642
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2080469
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1991144
94Hepatitis C_Homo sapiens_hsa05160-0.1945658
95Renin-angiotensin system_Homo sapiens_hsa04614-0.1889579
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1813351
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1714109
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1657968
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1622626
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1586802
101Regulation of autophagy_Homo sapiens_hsa04140-0.1556472
102African trypanosomiasis_Homo sapiens_hsa05143-0.1312036
103TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1073633
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1045491
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1024133
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0699640
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0696637
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0262897
109ECM-receptor interaction_Homo sapiens_hsa04512-0.0019511

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