APOA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.25490653
2intestinal absorption (GO:0050892)9.12836310
3angiotensin maturation (GO:0002003)7.13592764
4regulation of guanylate cyclase activity (GO:0031282)7.05220628
5NADH metabolic process (GO:0006734)6.73203008
6fat-soluble vitamin biosynthetic process (GO:0042362)6.34266420
7* triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26163761
8negative regulation of sterol transport (GO:0032372)5.81733779
9negative regulation of cholesterol transport (GO:0032375)5.81733779
10drug catabolic process (GO:0042737)5.64932985
11flavonoid metabolic process (GO:0009812)5.56894090
12* phospholipid efflux (GO:0033700)5.55092801
13very-low-density lipoprotein particle assembly (GO:0034379)5.49369015
14positive regulation of guanylate cyclase activity (GO:0031284)5.45144138
15regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.38344067
16* cholesterol efflux (GO:0033344)5.31930149
17urea metabolic process (GO:0019627)5.24451195
18urea cycle (GO:0000050)5.24451195
19vitamin A metabolic process (GO:0006776)5.07448356
20* regulation of triglyceride catabolic process (GO:0010896)5.03938239
21regulation of systemic arterial blood pressure by hormone (GO:0001990)5.03598414
22regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.03598414
23endocrine process (GO:0050886)5.03598414
24* plasma lipoprotein particle assembly (GO:0034377)5.02828971
25* reverse cholesterol transport (GO:0043691)4.87002667
26* lipoprotein metabolic process (GO:0042157)4.84962673
27alpha-linolenic acid metabolic process (GO:0036109)4.81146439
28triglyceride homeostasis (GO:0070328)4.78041363
29acylglycerol homeostasis (GO:0055090)4.78041363
30nitrogen cycle metabolic process (GO:0071941)4.76492341
31* high-density lipoprotein particle remodeling (GO:0034375)4.73496926
32* regulation of cholesterol esterification (GO:0010872)4.73242147
33* protein-lipid complex assembly (GO:0065005)4.69175970
34* protein-lipid complex remodeling (GO:0034368)4.68032446
35* macromolecular complex remodeling (GO:0034367)4.68032446
36* plasma lipoprotein particle remodeling (GO:0034369)4.68032446
37L-phenylalanine catabolic process (GO:0006559)4.65262982
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.65262982
39* cholesterol homeostasis (GO:0042632)4.60256367
40plasma lipoprotein particle clearance (GO:0034381)4.58527182
41L-phenylalanine metabolic process (GO:0006558)4.56973696
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.56973696
43* sterol homeostasis (GO:0055092)4.53796746
44regulation of systemic arterial blood pressure (GO:0003073)4.52336667
45hormone catabolic process (GO:0042447)4.45833462
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.41655960
47regulation of bile acid biosynthetic process (GO:0070857)4.38757683
48peptide hormone processing (GO:0016486)4.31049884
49regulation of cGMP biosynthetic process (GO:0030826)4.30779962
50* positive regulation of lipoprotein lipase activity (GO:0051006)4.23348938
51* positive regulation of triglyceride lipase activity (GO:0061365)4.23348938
52cysteine metabolic process (GO:0006534)4.21566167
53cellular response to nitric oxide (GO:0071732)4.20898575
54aromatic amino acid family catabolic process (GO:0009074)4.17004751
55receptor guanylyl cyclase signaling pathway (GO:0007168)4.13034732
56regulation of cellular extravasation (GO:0002691)4.12601979
57digestion (GO:0007586)4.12457707
58phospholipid homeostasis (GO:0055091)4.10801465
59regulation of cholesterol homeostasis (GO:2000188)4.09226549
60* plasma lipoprotein particle organization (GO:0071827)4.03113679
61* sterol transport (GO:0015918)4.02885773
62* cholesterol transport (GO:0030301)4.02885773
63renal system process involved in regulation of blood volume (GO:0001977)3.99723646
64glutamine family amino acid biosynthetic process (GO:0009084)3.93282083
65* protein-lipid complex subunit organization (GO:0071825)3.90691331
66glucose 6-phosphate metabolic process (GO:0051156)3.89504712
67cellular glucuronidation (GO:0052695)3.88132999
68adhesion of symbiont to host cell (GO:0044650)3.87426704
69virion attachment to host cell (GO:0019062)3.87426704
70drinking behavior (GO:0042756)3.87358006
71bile acid and bile salt transport (GO:0015721)3.85284020
72lipoprotein transport (GO:0042953)3.82649787
73bile acid biosynthetic process (GO:0006699)3.80646079
74heme transport (GO:0015886)3.80341469
75kynurenine metabolic process (GO:0070189)3.79608103
76fat-soluble vitamin metabolic process (GO:0006775)3.78423040
77homocysteine metabolic process (GO:0050667)3.77982746
78glyoxylate metabolic process (GO:0046487)3.77817211
79positive regulation of glycoprotein biosynthetic process (GO:0010560)3.77064250
80indole-containing compound catabolic process (GO:0042436)3.75747736
81indolalkylamine catabolic process (GO:0046218)3.75747736
82tryptophan catabolic process (GO:0006569)3.75747736
83vitamin transmembrane transport (GO:0035461)3.73608883
84diacylglycerol metabolic process (GO:0046339)3.72513069
85maintenance of gastrointestinal epithelium (GO:0030277)3.72109354
86amino-acid betaine metabolic process (GO:0006577)3.71294939
87drug metabolic process (GO:0017144)3.70632745
88vitamin transport (GO:0051180)3.70493619
89modified amino acid transport (GO:0072337)3.69610265
90* positive regulation of lipid catabolic process (GO:0050996)3.66676665
91purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.65994017
923-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.65994017
93lysine catabolic process (GO:0006554)3.65977913
94lysine metabolic process (GO:0006553)3.65977913
95digestive system process (GO:0022600)3.65309078
96L-ascorbic acid metabolic process (GO:0019852)3.64927754
97glycolipid catabolic process (GO:0019377)3.63923324
98alkaloid metabolic process (GO:0009820)3.61495535
99response to nitric oxide (GO:0071731)3.58835750
100cellular response to reactive nitrogen species (GO:1902170)3.57627750
101glycosphingolipid catabolic process (GO:0046479)3.57464667
102regulation of cGMP metabolic process (GO:0030823)3.56911173
103adhesion of symbiont to host (GO:0044406)3.56870389
104bile acid metabolic process (GO:0008206)3.54969056
105tryptophan metabolic process (GO:0006568)3.53970100
106exogenous drug catabolic process (GO:0042738)3.53814644
107* lipid homeostasis (GO:0055088)3.49838879
108negative regulation of fibrinolysis (GO:0051918)3.48785021
109glucuronate metabolic process (GO:0019585)3.46034634
110uronic acid metabolic process (GO:0006063)3.46034634
111sulfur amino acid catabolic process (GO:0000098)3.44383453
112vitamin biosynthetic process (GO:0009110)3.44291845
113drug transport (GO:0015893)3.44145677
114drug transmembrane transport (GO:0006855)3.43747843
115negative regulation of lipase activity (GO:0060192)3.41716706
116positive regulation of glycoprotein metabolic process (GO:1903020)3.39634610
117nucleoside diphosphate biosynthetic process (GO:0009133)3.39194061
118arginine metabolic process (GO:0006525)3.36932020
119protein carboxylation (GO:0018214)3.36066697
120peptidyl-glutamic acid carboxylation (GO:0017187)3.36066697
121regulation of vitamin metabolic process (GO:0030656)3.35548222
122nucleobase catabolic process (GO:0046113)3.34103309
123positive regulation of pseudopodium assembly (GO:0031274)3.33643958
124negative regulation of digestive system process (GO:0060457)3.31047371
125transepithelial transport (GO:0070633)3.29520464
126response to nitrosative stress (GO:0051409)3.28812329
127vitamin D metabolic process (GO:0042359)3.28671032
128regulation of protein activation cascade (GO:2000257)3.27881393
129regulation of fibrinolysis (GO:0051917)3.27845889
130glutamate metabolic process (GO:0006536)3.27136554
131urate metabolic process (GO:0046415)3.26466894
132regulation of cytokine secretion involved in immune response (GO:0002739)3.26299116
133cellular ketone body metabolic process (GO:0046950)3.25326940
134low-density lipoprotein particle remodeling (GO:0034374)3.23776381
135fructose metabolic process (GO:0006000)3.22752497
136antibacterial humoral response (GO:0019731)3.20980855
137epoxygenase P450 pathway (GO:0019373)3.20734245
138positive regulation of cGMP biosynthetic process (GO:0030828)3.17708736
139proline metabolic process (GO:0006560)3.17577162
140peptide catabolic process (GO:0043171)3.16330870
141antimicrobial humoral response (GO:0019730)3.16173161
142cobalamin metabolic process (GO:0009235)3.14569409
143* positive regulation of triglyceride metabolic process (GO:0090208)3.13376255
144cGMP biosynthetic process (GO:0006182)3.12823213
145leukotriene metabolic process (GO:0006691)3.11943033
146phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.10323979
147glycosylceramide metabolic process (GO:0006677)3.09232918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.31717830
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.59300630
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.08415938
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.49273974
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.36487464
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.54303628
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.38163327
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.81773239
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.64247443
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.42088337
11* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.90692546
12* CDX2_20551321_ChIP-Seq_CACO-2_Human2.80722059
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.63345844
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.55353605
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.42676371
16GATA4_25053715_ChIP-Seq_YYC3_Human2.10187875
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94835038
18CLOCK_20551151_ChIP-Seq_293T_Human1.75573050
19GATA1_22025678_ChIP-Seq_K562_Human1.72246290
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64387213
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.62784655
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60704777
23GATA6_25053715_ChIP-Seq_YYC3_Human1.57922209
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53528835
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.52342104
26SOX2_20726797_ChIP-Seq_SW620_Human1.51701000
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47962476
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.47555256
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44731226
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43041621
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27021131
32SA1_27219007_Chip-Seq_Bcells_Human1.24733987
33JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.18068484
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.18055282
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16661232
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15980008
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.15156156
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14691176
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14360128
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12487340
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10904138
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08999461
43* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08956542
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04624996
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03824967
46NANOG_20526341_ChIP-Seq_ESCs_Human1.03046090
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02516102
48GATA2_19941826_ChIP-Seq_K562_Human1.02428904
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02255618
50CDX2_22108803_ChIP-Seq_LS180_Human1.01397811
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01350934
52IRF8_21731497_ChIP-ChIP_J774_Mouse0.98808078
53HTT_18923047_ChIP-ChIP_STHdh_Human0.97548070
54FOXO3_23340844_ChIP-Seq_DLD1_Human0.96728779
55CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96291187
56IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96103440
57IRF8_22096565_ChIP-ChIP_GC-B_Human0.92789687
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91159555
59LXR_22292898_ChIP-Seq_THP-1_Human0.90244898
60DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89242825
61P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88994217
62RACK7_27058665_Chip-Seq_MCF-7_Human0.88320540
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87848667
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87178082
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86387529
66CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85307159
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85302911
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85127323
69RXR_22108803_ChIP-Seq_LS180_Human0.85024275
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84566978
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84170409
72* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84110487
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83336193
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83028865
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82025538
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81987192
77EGR1_19032775_ChIP-ChIP_M12_Human0.80725055
78PHF8_20622854_ChIP-Seq_HELA_Human0.80262345
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79409302
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78909612
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78159274
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77828336
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77753859
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77136379
85RARA_24833708_ChIP-Seq_LIVER_Mouse0.76618438
86* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.76565255
87TP63_22573176_ChIP-Seq_HFKS_Human0.76234919
88RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76065215
89ATF3_27146783_Chip-Seq_COLON_Human0.75651791
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75245324
91RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75091571
92ESR1_21235772_ChIP-Seq_MCF-7_Human0.73315623
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.72352432
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72333430
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72008447
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.71963358
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71496923
98GATA1_19941826_ChIP-Seq_K562_Human0.70736231
99CREB1_26743006_Chip-Seq_LNCaP_Human0.70576908
100BCOR_27268052_Chip-Seq_Bcells_Human0.67200697
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66520703
102CTCF_27219007_Chip-Seq_Bcells_Human0.65497392
103KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65390072
104KLF5_25053715_ChIP-Seq_YYC3_Human0.65254976
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.64714514
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64684496
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64565650
108MYC_19915707_ChIP-ChIP_AK7_Human0.63870642
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63610863
110CEBPB_22108803_ChIP-Seq_LS180_Human0.63497625
111ZNF263_19887448_ChIP-Seq_K562_Human0.63124484
112BCL6_27268052_Chip-Seq_Bcells_Human0.62727619
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62512177
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61823371
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.61526425
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.61256338
117STAT1_17558387_ChIP-Seq_HELA_Human0.61004055
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.60497743
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.58272803
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.58046717
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.57998610
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.57081207
123TAF2_19829295_ChIP-Seq_ESCs_Human0.57035735
124TP63_23658742_ChIP-Seq_EP156T_Human0.56876350
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55343483
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53964975
127* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53637635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.88641190
2MP0002139_abnormal_hepatobiliary_system7.30811162
3MP0005085_abnormal_gallbladder_physiolo5.23772037
4MP0001666_abnormal_nutrient_absorption5.22588611
5MP0008875_abnormal_xenobiotic_pharmacok4.55090933
6MP0005365_abnormal_bile_salt4.40028980
7MP0003252_abnormal_bile_duct4.20204667
8* MP0010329_abnormal_lipoprotein_level3.54688063
9MP0003806_abnormal_nucleotide_metabolis2.89307784
10* MP0009840_abnormal_foam_cell2.88999857
11MP0004019_abnormal_vitamin_homeostasis2.53099079
12MP0003191_abnormal_cellular_cholesterol2.39393602
13MP0003183_abnormal_peptide_metabolism2.34902283
14MP0005409_darkened_coat_color2.31039695
15MP0005332_abnormal_amino_acid2.22667147
16MP0009697_abnormal_copulation2.09717558
17MP0010234_abnormal_vibrissa_follicle2.03180042
18MP0004264_abnormal_extraembryonic_tissu1.94322210
19MP0000609_abnormal_liver_physiology1.84182104
20* MP0002118_abnormal_lipid_homeostasis1.80759899
21MP0005670_abnormal_white_adipose1.78056335
22MP0004270_analgesia1.58160956
23MP0002254_reproductive_system_inflammat1.56337932
24MP0005084_abnormal_gallbladder_morpholo1.52274926
25MP0000462_abnormal_digestive_system1.48424164
26MP0005083_abnormal_biliary_tract1.45414872
27MP0003705_abnormal_hypodermis_morpholog1.42772507
28MP0000490_abnormal_crypts_of1.42138825
29MP0003879_abnormal_hair_cell1.41746453
30MP0005319_abnormal_enzyme/_coenzyme1.39154555
31MP0002822_catalepsy1.37388160
32MP0005451_abnormal_body_composition1.33668112
33MP0001764_abnormal_homeostasis1.31735193
34MP0001188_hyperpigmentation1.29612470
35MP0009643_abnormal_urine_homeostasis1.26806536
36MP0004147_increased_porphyrin_level1.22578158
37MP0005448_abnormal_energy_balance1.20966195
38MP0000678_abnormal_parathyroid_gland1.19099271
39MP0005584_abnormal_enzyme/coenzyme_acti1.14563146
40MP0004043_abnormal_pH_regulation1.13371117
41MP0003866_abnormal_defecation1.11149083
42MP0003195_calcinosis1.09591444
43MP0003868_abnormal_feces_composition1.06039964
44MP0002138_abnormal_hepatobiliary_system1.03307577
45MP0000604_amyloidosis1.01478281
46MP0004858_abnormal_nervous_system0.96182632
47MP0002796_impaired_skin_barrier0.92206261
48MP0003718_maternal_effect0.91880218
49MP0003656_abnormal_erythrocyte_physiolo0.88449622
50MP0005058_abnormal_lysosome_morphology0.87188007
51MP0000538_abnormal_urinary_bladder0.85791820
52MP0000598_abnormal_liver_morphology0.85572620
53MP0002876_abnormal_thyroid_physiology0.84826289
54MP0001501_abnormal_sleep_pattern0.84352624
55MP0005266_abnormal_metabolism0.83374427
56MP0005636_abnormal_mineral_homeostasis0.83136049
57MP0003300_gastrointestinal_ulcer0.83073621
58MP0005381_digestive/alimentary_phenotyp0.82349900
59MP0001663_abnormal_digestive_system0.81767069
60MP0004782_abnormal_surfactant_physiolog0.81422874
61MP0009053_abnormal_anal_canal0.81349365
62* MP0009642_abnormal_blood_homeostasis0.80458417
63MP0009764_decreased_sensitivity_to0.80217178
64MP0005376_homeostasis/metabolism_phenot0.76550074
65MP0009765_abnormal_xenobiotic_induced0.74047031
66* MP0001845_abnormal_inflammatory_respons0.70541827
67MP0000477_abnormal_intestine_morphology0.69020136
68MP0008469_abnormal_protein_level0.68570841
69MP0002078_abnormal_glucose_homeostasis0.68569305
70MP0002089_abnormal_postnatal_growth/wei0.68307953
71MP0002971_abnormal_brown_adipose0.67020791
72MP0001664_abnormal_digestion0.65265820
73MP0000537_abnormal_urethra_morphology0.63657597
74MP0005666_abnormal_adipose_tissue0.61997981
75MP0003638_abnormal_response/metabolism_0.61844420
76MP0005334_abnormal_fat_pad0.61689829
77MP0009785_altered_susceptibility_to0.61283032
78MP0002136_abnormal_kidney_physiology0.59943132
79MP0009763_increased_sensitivity_to0.59180451
80MP0001485_abnormal_pinna_reflex0.57662327
81MP0008872_abnormal_physiological_respon0.56672238
82MP0001986_abnormal_taste_sensitivity0.56273096
83MP0005377_hearing/vestibular/ear_phenot0.56095970
84MP0003878_abnormal_ear_physiology0.56095970
85MP0004947_skin_inflammation0.55813409
86MP0009115_abnormal_fat_cell0.55472015
87MP0005166_decreased_susceptibility_to0.55007955
88MP0009379_abnormal_foot_pigmentation0.54626671
89* MP0000249_abnormal_blood_vessel0.54358539
90MP0000516_abnormal_urinary_system0.53341699
91MP0005367_renal/urinary_system_phenotyp0.53341699
92MP0005167_abnormal_blood-brain_barrier0.52800563
93MP0001873_stomach_inflammation0.51874724
94MP0006138_congestive_heart_failure0.51640606
95MP0003011_delayed_dark_adaptation0.51240865
96MP0006082_CNS_inflammation0.51080857
97MP0003436_decreased_susceptibility_to0.50948966
98MP0000467_abnormal_esophagus_morphology0.50858964
99MP0008260_abnormal_autophagy0.50040638
100MP0002396_abnormal_hematopoietic_system0.49481255
101MP0005464_abnormal_platelet_physiology0.48991684
102* MP0010155_abnormal_intestine_physiology0.48939681
103MP0003329_amyloid_beta_deposits0.48407830
104MP0006054_spinal_hemorrhage0.48281136
105MP0001756_abnormal_urination0.47877949
106MP0009780_abnormal_chondrocyte_physiolo0.47272135
107MP0010352_gastrointestinal_tract_polyps0.46811752
108MP0005025_abnormal_response_to0.46010381
109MP0009333_abnormal_splenocyte_physiolog0.45961041
110MP0005408_hypopigmentation0.45656476
111MP0008004_abnormal_stomach_pH0.44592778
112MP0005174_abnormal_tail_pigmentation0.43648286
113MP0005501_abnormal_skin_physiology0.43492476
114MP0009384_cardiac_valve_regurgitation0.42658299
115MP0008873_increased_physiological_sensi0.41912111
116MP0002135_abnormal_kidney_morphology0.41150715
117MP0001881_abnormal_mammary_gland0.40875984
118MP0005535_abnormal_body_temperature0.40850358
119MP0002098_abnormal_vibrissa_morphology0.40074226
120MP0003953_abnormal_hormone_level0.39863312
121MP0005395_other_phenotype0.39781773
122MP0003453_abnormal_keratinocyte_physiol0.39551384
123MP0003724_increased_susceptibility_to0.39531080
124MP0000230_abnormal_systemic_arterial0.39005961
125MP0000427_abnormal_hair_cycle0.38111070
126MP0001765_abnormal_ion_homeostasis0.37352521
127MP0006036_abnormal_mitochondrial_physio0.37081699
128MP0005647_abnormal_sex_gland0.31685290
129MP0003186_abnormal_redox_activity0.31617842
130MP0000579_abnormal_nail_morphology0.31477340

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)8.66510802
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.33595326
3Xanthomatosis (HP:0000991)5.95177626
4Acanthocytosis (HP:0001927)5.85226730
5Hypolipoproteinemia (HP:0010981)5.75358060
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.61039168
7Intrahepatic cholestasis (HP:0001406)5.49762999
8Ileus (HP:0002595)4.99090935
9Conjugated hyperbilirubinemia (HP:0002908)4.93585618
10Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.89990100
11Fat malabsorption (HP:0002630)4.73837626
12Deep venous thrombosis (HP:0002625)4.72265770
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.60058481
14Malnutrition (HP:0004395)4.52498081
15Hyperglycinuria (HP:0003108)4.25795754
16Autoimmune thrombocytopenia (HP:0001973)4.15855571
17Epidermoid cyst (HP:0200040)4.10458853
18Abnormality of proline metabolism (HP:0010907)4.06846086
19Hydroxyprolinuria (HP:0003080)4.06846086
20Prolonged partial thromboplastin time (HP:0003645)4.04219085
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95777368
22Hypercholesterolemia (HP:0003124)3.91633498
23Hyperammonemia (HP:0001987)3.88818212
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.78392379
25Poikilocytosis (HP:0004447)3.77928305
26Abnormality of glycine metabolism (HP:0010895)3.66544099
27Abnormality of serine family amino acid metabolism (HP:0010894)3.66544099
28Hypoalphalipoproteinemia (HP:0003233)3.66480330
29Hyperlipoproteinemia (HP:0010980)3.62339281
30Pigmentary retinal degeneration (HP:0001146)3.46826293
31Hypoglycemic coma (HP:0001325)3.44945703
32Wide cranial sutures (HP:0010537)3.31208838
33Abnormality of the common coagulation pathway (HP:0010990)3.25487141
34Hyperuricemia (HP:0002149)3.20320011
35Increased purine levels (HP:0004368)3.20320011
36Hyperbilirubinemia (HP:0002904)3.09347223
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.07870294
38Complement deficiency (HP:0004431)3.06292114
39Ketosis (HP:0001946)3.03111461
40Thin bony cortex (HP:0002753)3.02851895
41Abnormality of purine metabolism (HP:0004352)2.99243281
42Abnormality of nucleobase metabolism (HP:0010932)2.99068130
43Abnormality of pyrimidine metabolism (HP:0004353)2.98717829
44Metabolic acidosis (HP:0001942)2.98266985
45Abnormal gallbladder physiology (HP:0012438)2.93743014
46Cholecystitis (HP:0001082)2.93743014
47Congenital sensorineural hearing impairment (HP:0008527)2.92993593
48Cupped ribs (HP:0000887)2.90925632
49Abnormality of urine glucose concentration (HP:0011016)2.89959837
50Glycosuria (HP:0003076)2.89959837
51Posterior subcapsular cataract (HP:0007787)2.83691482
52Reticulocytosis (HP:0001923)2.80425135
53Abnormality of fatty-acid metabolism (HP:0004359)2.76501672
54Autoimmune hemolytic anemia (HP:0001890)2.74950429
55Gout (HP:0001997)2.74368235
56Hypophosphatemia (HP:0002148)2.74128914
57Right ventricular cardiomyopathy (HP:0011663)2.68046763
58Hyperglycinemia (HP:0002154)2.67402418
59Glomerulonephritis (HP:0000099)2.65305587
60Widely patent fontanelles and sutures (HP:0004492)2.65239279
61Potter facies (HP:0002009)2.64397566
62Facial shape deformation (HP:0011334)2.64397566
63Ketoacidosis (HP:0001993)2.62844214
64Joint hemorrhage (HP:0005261)2.62126120
65Amyloidosis (HP:0011034)2.60520557
66Abnormal urine phosphate concentration (HP:0012599)2.54020623
67Mesangial abnormality (HP:0001966)2.53595186
68Abnormality of the intrinsic pathway (HP:0010989)2.53334971
69Alkalosis (HP:0001948)2.53079623
70Decreased circulating renin level (HP:0003351)2.48467191
71Skin nodule (HP:0200036)2.44196511
72Increased mean platelet volume (HP:0011877)2.43794084
73Abnormality of vitamin metabolism (HP:0100508)2.40978620
74Abnormality of methionine metabolism (HP:0010901)2.39053312
75Confusion (HP:0001289)2.38917645
76Focal segmental glomerulosclerosis (HP:0000097)2.38066808
77Hypoglycemic seizures (HP:0002173)2.35909632
78Polycythemia (HP:0001901)2.35347995
79Nephrolithiasis (HP:0000787)2.34701705
80Abdominal distention (HP:0003270)2.32002927
81Cholelithiasis (HP:0001081)2.31567844
82Abnormality of magnesium homeostasis (HP:0004921)2.30658768
83Metabolic alkalosis (HP:0200114)2.29649206
84Abnormal gallbladder morphology (HP:0012437)2.28257262
85Late onset (HP:0003584)2.27434030
86Pancreatitis (HP:0001733)2.27369937
87Subcapsular cataract (HP:0000523)2.26465367
88Abnormality of complement system (HP:0005339)2.23794920
89Hypotension (HP:0002615)2.22465107
90Cerebral palsy (HP:0100021)2.22384539
91Hemorrhage of the eye (HP:0011885)2.20823557
92Increased IgE level (HP:0003212)2.20504379
93Eczematoid dermatitis (HP:0000976)2.19087878
94Spontaneous abortion (HP:0005268)2.17517843
95Sensorimotor neuropathy (HP:0007141)2.17239999
96Steatorrhea (HP:0002570)2.16509568
97Hyperactive renin-angiotensin system (HP:0000841)2.16494508
98Systemic lupus erythematosus (HP:0002725)2.16326347
99Abnormality of small intestinal villus morphology (HP:0011472)2.15120745
100Villous atrophy (HP:0011473)2.15120745
101Vascular calcification (HP:0004934)2.13782452
102Enlarged epiphyses (HP:0010580)2.13179523
103Delayed epiphyseal ossification (HP:0002663)2.13162366
104Abnormal platelet volume (HP:0011876)2.12693579
105Protuberant abdomen (HP:0001538)2.09549871
106Nausea (HP:0002018)2.08848535
107Symptomatic seizures (HP:0011145)2.07582664
108Hyperparathyroidism (HP:0000843)2.06280513
109Abnormality of transition element cation homeostasis (HP:0011030)2.05129291
110Hyperinsulinemic hypoglycemia (HP:0000825)2.03593803
111Megaloblastic anemia (HP:0001889)2.01878402
112Nephritis (HP:0000123)2.00969133
113Abnormality of the costochondral junction (HP:0000919)1.99372552
114Hepatocellular carcinoma (HP:0001402)1.98630866
115Proximal tubulopathy (HP:0000114)1.98558962
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98453467
117Dicarboxylic aciduria (HP:0003215)1.98453467
118Irritability (HP:0000737)1.98056099
119Renal tubular acidosis (HP:0001947)1.97845428
120Hyperphosphaturia (HP:0003109)1.97389527
121Chronic diarrhea (HP:0002028)1.97385598
122Abnormal glucose tolerance (HP:0001952)1.95363157
123Lethargy (HP:0001254)1.94160191
124Myocardial infarction (HP:0001658)1.92469307
125Gastrointestinal dysmotility (HP:0002579)1.91820455
126Vacuolated lymphocytes (HP:0001922)1.91582256
127Esophageal varix (HP:0002040)1.91021467
128Abnormality of the vitamin B12 metabolism (HP:0004341)1.90082297
129Delayed CNS myelination (HP:0002188)1.90055747
130Abnormality of vitamin B metabolism (HP:0004340)1.89840009
131Abnormality of alkaline phosphatase activity (HP:0004379)1.89127981
132Cardiovascular calcification (HP:0011915)1.88395851
133Gingival bleeding (HP:0000225)1.88336603
134Abnormal enzyme/coenzyme activity (HP:0012379)1.88169784
135Abnormality of renin-angiotensin system (HP:0000847)1.83202188
136Glomerulosclerosis (HP:0000096)1.78653537
137White forelock (HP:0002211)1.76441667
138Joint swelling (HP:0001386)1.74064401
139Patchy hypopigmentation of hair (HP:0011365)1.72183673
140Gingivitis (HP:0000230)1.71999030
141Renal tubular dysfunction (HP:0000124)1.71175212
142Growth hormone excess (HP:0000845)1.67644204
143Hyperphosphatemia (HP:0002905)1.66320168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.05324055
2FRK5.52317728
3MST1R4.44278787
4ERN13.98425992
5MST43.70379254
6GRK63.61965653
7LMTK23.23048348
8PRKG22.73095008
9BCKDK2.66562638
10MAP3K102.57337332
11RIPK12.45619356
12PTK62.43848771
13EPHA22.42571553
14FGFR42.18819079
15NME12.15497427
16AKT32.04022068
17TAOK32.02974581
18MAP3K121.91540454
19SIK11.83009905
20MAP3K21.81190425
21NUAK11.76345021
22MUSK1.75153208
23MET1.71797802
24MAP2K21.71790218
25TNIK1.59881741
26ERBB41.45614348
27EPHB21.40500578
28STK391.32703080
29LATS11.32477463
30EPHA41.30215384
31INSRR1.29730456
32EPHB11.29277851
33MAP3K111.28260701
34MAPK111.23748972
35MAP3K71.19640069
36OXSR11.18914218
37PRKAA21.15497919
38TBK11.15429992
39PKN21.12329639
40TESK21.11919246
41TYK21.11548962
42MAP3K31.08388394
43MAP2K61.05853152
44MAP2K41.00763953
45PTK21.00755065
46BMX0.99533804
47TAOK10.97177972
48STK100.96180126
49ERBB20.92898538
50NLK0.87963745
51FGFR30.85990604
52KSR20.83755126
53TRIB30.81792728
54PRPF4B0.76846018
55CDC42BPA0.76521945
56STK240.75840104
57MAP3K80.74093059
58FER0.74076859
59MAP3K10.72122223
60MAP2K10.72107904
61DYRK1B0.71308203
62PDPK10.69311605
63PBK0.66727147
64DDR20.64489955
65MATK0.64344548
66CSK0.63349031
67ICK0.61570650
68CDK190.60193503
69JAK20.58560686
70PRKAA10.58557221
71PIK3CG0.57613935
72PRKCI0.57558327
73CDK60.56690710
74TESK10.55481448
75FLT30.55428080
76PRKACG0.55353629
77KDR0.54146541
78PIM10.53535299
79IRAK30.52495919
80MAPK40.50092172
81CASK0.48239233
82PAK30.46427894
83PRKCZ0.46194726
84ABL20.44685821
85CSF1R0.43842702
86GSK3A0.43536646
87MAP4K10.42525903
88PDK10.42342642
89MYLK0.41972402
90EPHA30.41137248
91PRKCQ0.40383757
92NEK60.38946091
93CAMK2G0.38765620
94JAK10.38714743
95SCYL20.37168360
96DAPK20.36510257
97NEK90.36485374
98GRK10.36399088
99PAK40.35630329
100FYN0.35629155
101PRKCA0.34842441
102MAP2K30.34245063
103ZAP700.33524600
104IRAK10.32646416
105CAMK2D0.31629694
106MAP3K140.30386974
107PIK3CA0.29320038
108MAPK70.28575197
109LRRK20.28310646
110SYK0.27933435
111TTK0.27472949
112CAMK2B0.27395493
113PDGFRA0.26960911
114BTK0.24725368
115BMPR20.23915816
116IKBKE0.23781943
117SRC0.23659104
118RET0.22998392
119PDK20.22979842
120PRKACA0.22532888
121AKT20.20844860
122YES10.19972228
123PRKCD0.19753629
124IGF1R0.19605899
125SGK30.19557546
126MAP3K50.19416701
127RIPK40.18427546
128LCK0.18076032
129DAPK30.17807569
130ITK0.17693257
131STK30.16989558
132NTRK30.16332664

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fat digestion and absorption_Homo sapiens_hsa049754.08802986
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.29234567
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03481533
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.84822746
5Nitrogen metabolism_Homo sapiens_hsa009102.68030899
6Arginine biosynthesis_Homo sapiens_hsa002202.65368042
7Caffeine metabolism_Homo sapiens_hsa002322.64023975
8* Vitamin digestion and absorption_Homo sapiens_hsa049772.49975450
9Renin-angiotensin system_Homo sapiens_hsa046142.44531811
10Starch and sucrose metabolism_Homo sapiens_hsa005002.37419734
11Tryptophan metabolism_Homo sapiens_hsa003802.30027140
12Fatty acid degradation_Homo sapiens_hsa000712.22814702
13Folate biosynthesis_Homo sapiens_hsa007902.12457747
14Histidine metabolism_Homo sapiens_hsa003402.11389233
15PPAR signaling pathway_Homo sapiens_hsa033202.09020212
16Bile secretion_Homo sapiens_hsa049762.04618468
17Mineral absorption_Homo sapiens_hsa049782.01853272
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96414984
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95364879
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93823298
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89226477
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86468816
23Galactose metabolism_Homo sapiens_hsa000521.84556379
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.77108067
25Sulfur metabolism_Homo sapiens_hsa009201.69942745
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69246054
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62110272
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58398713
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57590442
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57067715
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56125062
32Peroxisome_Homo sapiens_hsa041461.55500959
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52680974
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.51165391
35Chemical carcinogenesis_Homo sapiens_hsa052041.51085388
36Complement and coagulation cascades_Homo sapiens_hsa046101.49787178
37Butanoate metabolism_Homo sapiens_hsa006501.48662186
38Fatty acid metabolism_Homo sapiens_hsa012121.47852925
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.43553711
40beta-Alanine metabolism_Homo sapiens_hsa004101.37028648
41Retinol metabolism_Homo sapiens_hsa008301.34727566
42Pyruvate metabolism_Homo sapiens_hsa006201.28722171
43ABC transporters_Homo sapiens_hsa020101.26665849
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.24997780
45Glycerolipid metabolism_Homo sapiens_hsa005611.24997132
46Fructose and mannose metabolism_Homo sapiens_hsa000511.20063066
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16679713
48Propanoate metabolism_Homo sapiens_hsa006401.15962630
49Arginine and proline metabolism_Homo sapiens_hsa003301.13042519
50Glutathione metabolism_Homo sapiens_hsa004801.12578918
51Carbon metabolism_Homo sapiens_hsa012001.09898443
52Protein digestion and absorption_Homo sapiens_hsa049741.05125108
53Selenocompound metabolism_Homo sapiens_hsa004501.03633103
54Phenylalanine metabolism_Homo sapiens_hsa003601.03300600
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02191499
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00781451
57Biosynthesis of amino acids_Homo sapiens_hsa012300.99384238
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97262341
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89726118
60Fatty acid elongation_Homo sapiens_hsa000620.84897684
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84278659
62Tyrosine metabolism_Homo sapiens_hsa003500.83145146
63Other glycan degradation_Homo sapiens_hsa005110.82238009
64Staphylococcus aureus infection_Homo sapiens_hsa051500.79662529
65Steroid biosynthesis_Homo sapiens_hsa001000.78777646
66Asthma_Homo sapiens_hsa053100.74080906
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71030292
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.70737699
69Fatty acid biosynthesis_Homo sapiens_hsa000610.69641145
70Pentose phosphate pathway_Homo sapiens_hsa000300.68576047
71Lysine degradation_Homo sapiens_hsa003100.62198962
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54345832
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51534666
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51317704
75Allograft rejection_Homo sapiens_hsa053300.48737830
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.48348657
77Autoimmune thyroid disease_Homo sapiens_hsa053200.44486269
78Sulfur relay system_Homo sapiens_hsa041220.43554248
79Graft-versus-host disease_Homo sapiens_hsa053320.41151635
80Metabolic pathways_Homo sapiens_hsa011000.40832149
81Sphingolipid metabolism_Homo sapiens_hsa006000.32366007
82Linoleic acid metabolism_Homo sapiens_hsa005910.30250403
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29266830
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27377256
85Type I diabetes mellitus_Homo sapiens_hsa049400.24644094
86Cocaine addiction_Homo sapiens_hsa050300.24021412
87Renin secretion_Homo sapiens_hsa049240.23864173
88Thyroid hormone synthesis_Homo sapiens_hsa049180.23723978
89Insulin resistance_Homo sapiens_hsa049310.20515027
90Vitamin B6 metabolism_Homo sapiens_hsa007500.19389583
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17272612
92Type II diabetes mellitus_Homo sapiens_hsa049300.15023811
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14772614
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12463741
95African trypanosomiasis_Homo sapiens_hsa051430.10818981
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.10707328
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08772142
98Arachidonic acid metabolism_Homo sapiens_hsa005900.08649775
99Antigen processing and presentation_Homo sapiens_hsa046120.07814234
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.04849780
101GnRH signaling pathway_Homo sapiens_hsa049120.04277058
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04034955
103Leishmaniasis_Homo sapiens_hsa051400.03564205
104Thyroid cancer_Homo sapiens_hsa05216-0.1708217
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1584973
106Pancreatic secretion_Homo sapiens_hsa04972-0.1359723
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1293516
108Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1041678
109One carbon pool by folate_Homo sapiens_hsa00670-0.1038386
110Tight junction_Homo sapiens_hsa04530-0.0992863
111Prion diseases_Homo sapiens_hsa05020-0.0779961
112Glucagon signaling pathway_Homo sapiens_hsa04922-0.0748468
113Ether lipid metabolism_Homo sapiens_hsa00565-0.0638285
114AMPK signaling pathway_Homo sapiens_hsa04152-0.0588288
115Bladder cancer_Homo sapiens_hsa05219-0.0353456
116Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0329007
117Hepatitis C_Homo sapiens_hsa05160-0.0110368

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