APOA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.94013967
2epoxygenase P450 pathway (GO:0019373)8.59674909
3omega-hydroxylase P450 pathway (GO:0097267)8.57170382
4L-phenylalanine catabolic process (GO:0006559)7.67965869
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.67965869
6L-phenylalanine metabolic process (GO:0006558)7.34924369
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.34924369
8aromatic amino acid family catabolic process (GO:0009074)6.88169870
9tryptophan catabolic process (GO:0006569)6.18362848
10indole-containing compound catabolic process (GO:0042436)6.18362848
11indolalkylamine catabolic process (GO:0046218)6.18362848
12kynurenine metabolic process (GO:0070189)6.05107246
13* triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01445425
14bile acid biosynthetic process (GO:0006699)5.98999324
15drug metabolic process (GO:0017144)5.95057866
16regulation of plasminogen activation (GO:0010755)5.87551354
17tryptophan metabolic process (GO:0006568)5.82289434
18glyoxylate metabolic process (GO:0046487)5.78752788
19alpha-linolenic acid metabolic process (GO:0036109)5.77938495
20urea cycle (GO:0000050)5.74996762
21urea metabolic process (GO:0019627)5.74996762
22high-density lipoprotein particle remodeling (GO:0034375)5.70670444
23oxidative demethylation (GO:0070989)5.69486469
24negative regulation of fibrinolysis (GO:0051918)5.62788190
25regulation of fibrinolysis (GO:0051917)5.42053709
26protein carboxylation (GO:0018214)5.40261608
27peptidyl-glutamic acid carboxylation (GO:0017187)5.40261608
28sulfur amino acid catabolic process (GO:0000098)5.35899749
29cysteine metabolic process (GO:0006534)5.32708857
30nitrogen cycle metabolic process (GO:0071941)5.28884845
31regulation of protein activation cascade (GO:2000257)5.27900042
32complement activation, alternative pathway (GO:0006957)5.27226982
33serine family amino acid catabolic process (GO:0009071)5.16553842
34acute-phase response (GO:0006953)5.13972358
35bile acid metabolic process (GO:0008206)5.13826929
36regulation of cholesterol esterification (GO:0010872)5.03587928
37aromatic amino acid family metabolic process (GO:0009072)5.00369710
38regulation of humoral immune response (GO:0002920)4.98460801
39reverse cholesterol transport (GO:0043691)4.97086086
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92972190
41regulation of complement activation (GO:0030449)4.90284064
42ethanol metabolic process (GO:0006067)4.89466775
43tyrosine metabolic process (GO:0006570)4.89030165
44negative regulation of protein activation cascade (GO:2000258)4.84160321
45phenylpropanoid metabolic process (GO:0009698)4.83984062
46negative regulation of hemostasis (GO:1900047)4.81340868
47negative regulation of blood coagulation (GO:0030195)4.81340868
48homocysteine metabolic process (GO:0050667)4.75919506
49phospholipid efflux (GO:0033700)4.73364063
50negative regulation of cholesterol transport (GO:0032375)4.70949009
51negative regulation of sterol transport (GO:0032372)4.70949009
52alpha-amino acid catabolic process (GO:1901606)4.68490898
53amino-acid betaine metabolic process (GO:0006577)4.64744189
54* protein-lipid complex remodeling (GO:0034368)4.61370617
55* macromolecular complex remodeling (GO:0034367)4.61370617
56* plasma lipoprotein particle remodeling (GO:0034369)4.61370617
57lysine catabolic process (GO:0006554)4.57984084
58lysine metabolic process (GO:0006553)4.57984084
59S-adenosylmethionine metabolic process (GO:0046500)4.55001858
60cellular ketone body metabolic process (GO:0046950)4.53311691
61* triglyceride homeostasis (GO:0070328)4.46841443
62* acylglycerol homeostasis (GO:0055090)4.46841443
63plasma lipoprotein particle clearance (GO:0034381)4.45518562
64coenzyme catabolic process (GO:0009109)4.45035155
65glycine metabolic process (GO:0006544)4.42810612
66bile acid and bile salt transport (GO:0015721)4.41991021
67* regulation of triglyceride catabolic process (GO:0010896)4.40952838
68disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.39756740
69killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.39756740
70imidazole-containing compound metabolic process (GO:0052803)4.38467468
71indolalkylamine metabolic process (GO:0006586)4.38273609
72negative regulation of coagulation (GO:0050819)4.37067026
73positive regulation of blood coagulation (GO:0030194)4.36932465
74positive regulation of hemostasis (GO:1900048)4.36932465
75negative regulation of wound healing (GO:0061045)4.32396533
76cholesterol efflux (GO:0033344)4.30935980
77cellular amino acid catabolic process (GO:0009063)4.30101412
78amine catabolic process (GO:0009310)4.29294460
79cellular biogenic amine catabolic process (GO:0042402)4.29294460
80cellular glucuronidation (GO:0052695)4.28312757
81glutamate metabolic process (GO:0006536)4.27835548
82alkaloid metabolic process (GO:0009820)4.25875770
83serine family amino acid metabolic process (GO:0009069)4.18322667
84benzene-containing compound metabolic process (GO:0042537)4.14409121
85intestinal cholesterol absorption (GO:0030299)4.09169027
86arginine metabolic process (GO:0006525)4.09016147
87plasma lipoprotein particle assembly (GO:0034377)4.07561350
88low-density lipoprotein particle remodeling (GO:0034374)4.07495978
89cellular modified amino acid catabolic process (GO:0042219)4.06723405
90ethanol oxidation (GO:0006069)4.06516547
91dicarboxylic acid biosynthetic process (GO:0043650)4.05310550
92fibrinolysis (GO:0042730)4.02488642
93aldehyde catabolic process (GO:0046185)4.02023200
94negative regulation of complement activation (GO:0045916)4.01825770
95drug catabolic process (GO:0042737)4.00925623
96positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.00748361
97positive regulation of coagulation (GO:0050820)4.00303820
98serine family amino acid biosynthetic process (GO:0009070)4.00089906
99regulation of apoptotic cell clearance (GO:2000425)3.97083135
100ketone body metabolic process (GO:1902224)3.92504148
101negative regulation of lipase activity (GO:0060192)3.88244615
102blood coagulation, intrinsic pathway (GO:0007597)3.86127025
103acute inflammatory response (GO:0002526)3.85214686
104cofactor catabolic process (GO:0051187)3.84048843
105very-low-density lipoprotein particle assembly (GO:0034379)3.80906847
106glucuronate metabolic process (GO:0019585)3.80060481
107uronic acid metabolic process (GO:0006063)3.80060481
108organic acid catabolic process (GO:0016054)3.77336699
109carboxylic acid catabolic process (GO:0046395)3.77336699
110regulation of bile acid biosynthetic process (GO:0070857)3.76829538
111phospholipid homeostasis (GO:0055091)3.74877662
112complement activation, classical pathway (GO:0006958)3.73844237
113protein activation cascade (GO:0072376)3.70564093
114complement activation (GO:0006956)3.70168111
115acetyl-CoA metabolic process (GO:0006084)3.69247951
116short-chain fatty acid metabolic process (GO:0046459)3.67209991
117regulation of cholesterol homeostasis (GO:2000188)3.66570378
118* cholesterol homeostasis (GO:0042632)3.66098615
119protein-lipid complex assembly (GO:0065005)3.64913181
120cytolysis (GO:0019835)3.60162101
121* sterol homeostasis (GO:0055092)3.59867409
122NAD biosynthetic process (GO:0009435)3.59227269
123opsonization (GO:0008228)3.56523044
124pyridine nucleotide biosynthetic process (GO:0019363)3.55975388
125nicotinamide nucleotide biosynthetic process (GO:0019359)3.55975388
126flavonoid metabolic process (GO:0009812)3.53077697
127proline metabolic process (GO:0006560)3.52327888
128response to mercury ion (GO:0046689)3.51865491
129positive regulation of fatty acid beta-oxidation (GO:0032000)3.51394528
130regulation of acute inflammatory response (GO:0002673)3.49301073
131hormone catabolic process (GO:0042447)3.44196740
132regulation of lipoprotein particle clearance (GO:0010984)3.41250593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.44642631
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22415673
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.00396683
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50760365
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23269308
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14014267
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88833763
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04322481
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01600224
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07604836
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0168283
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98970198
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97373230
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.59488935
15HTT_18923047_ChIP-ChIP_STHdh_Human1.55985432
16CLOCK_20551151_ChIP-Seq_293T_Human1.55686926
17GATA1_22025678_ChIP-Seq_K562_Human1.44423028
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.39977838
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31415168
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23811256
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19909766
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19710305
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17603978
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.15672245
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05302332
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00908112
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00385387
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93422684
29SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90373856
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89732460
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85374820
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84612849
33RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83399993
34IRF8_22096565_ChIP-ChIP_GC-B_Human0.82529635
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79865021
36GATA4_25053715_ChIP-Seq_YYC3_Human0.78476729
37* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78296072
38SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77745104
39KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76298995
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76076344
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75509989
42SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74688752
43RARA_24833708_ChIP-Seq_LIVER_Mouse0.73609199
44ZNF263_19887448_ChIP-Seq_K562_Human0.72185700
45RAC3_21632823_ChIP-Seq_H3396_Human0.71391016
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71194415
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70580896
48SMC4_20622854_ChIP-Seq_HELA_Human0.70459368
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70385099
50SOX2_21211035_ChIP-Seq_LN229_Human0.69968536
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66554408
52POU5F1_16518401_ChIP-PET_MESCs_Mouse0.66553732
53DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65726393
54SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65634566
55SRY_22984422_ChIP-ChIP_TESTIS_Rat0.64977071
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64785154
57ESR2_21235772_ChIP-Seq_MCF-7_Human0.64652775
58NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63347692
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63347692
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63231823
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63127990
62RARB_24833708_ChIP-Seq_LIVER_Mouse0.63118892
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.63077401
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61739018
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61210545
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60592643
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.58760898
68NFE2_27457419_Chip-Seq_LIVER_Mouse0.58756143
69E2F1_20622854_ChIP-Seq_HELA_Human0.58430716
70ELF1_20517297_ChIP-Seq_JURKAT_Human0.57598736
71CEBPB_22108803_ChIP-Seq_LS180_Human0.57331794
72SPI1_20517297_ChIP-Seq_HL60_Human0.56993874
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56783946
74TCF4_18268006_ChIP-ChIP_LS174T_Human0.56303822
75ETV2_25802403_ChIP-Seq_MESCs_Mouse0.55449375
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.55341140
77HNFA_21074721_ChIP-Seq_CACO-2_Human0.55048031
78LXR_22292898_ChIP-Seq_THP-1_Human0.54861571
79* CTCF_27219007_Chip-Seq_Bcells_Human0.54844473
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54259479
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.54246768
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.53816161
83EGR1_19032775_ChIP-ChIP_M12_Human0.53323637
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52827299
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.52533052
86MYC_19829295_ChIP-Seq_ESCs_Human0.52372620
87FOXA1_25552417_ChIP-Seq_VCAP_Human0.51830767
88AR_20517297_ChIP-Seq_VCAP_Human0.51729791
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51010897
90MYC_19915707_ChIP-ChIP_AK7_Human0.50886536
91NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.50414234
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50408657
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.49406739
94CTCF_20526341_ChIP-Seq_ESCs_Human0.49262408
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.49171755
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49096641
97PHF8_20622853_ChIP-Seq_HELA_Human0.48738001
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.48263408
99IRF1_19129219_ChIP-ChIP_H3396_Human0.48152725
100CBP_21632823_ChIP-Seq_H3396_Human0.47743768
101JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.47426676
102P53_21459846_ChIP-Seq_SAOS-2_Human0.46768014
103TP53_18474530_ChIP-ChIP_U2OS_Human0.46604804
104STAT1_17558387_ChIP-Seq_HELA_Human0.46515465
105PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46194446
106GATA6_21074721_ChIP-Seq_CACO-2_Human0.45894594
107* SA1_27219007_Chip-Seq_Bcells_Human0.45809669
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44361785
109TAF15_26573619_Chip-Seq_HEK293_Human0.43568721
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.42748682
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42605652
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42332864
113GATA1_19941826_ChIP-Seq_K562_Human0.41202918
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.41200328
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.41183950
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.40119014
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40063889
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.39861416
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.39403396
120GATA2_19941826_ChIP-Seq_K562_Human0.38944049
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38691872
122BCAT_22108803_ChIP-Seq_LS180_Human0.38660702
123STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38443827
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38441394
125* TAF2_19829295_ChIP-Seq_ESCs_Human0.38108105
126MYC_27129775_Chip-Seq_CORNEA_Mouse0.38032554
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.37181686
128GATA6_25053715_ChIP-Seq_YYC3_Human0.37118550
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35926834
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34860780
131SPI1_26923725_Chip-Seq_HPCs_Mouse0.34513810
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34079327
133NCOR_22424771_ChIP-Seq_293T_Human0.34010192
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.33454740
135SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33004449
136ERG_20517297_ChIP-Seq_VCAP_Human0.32436975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37958126
2MP0005360_urolithiasis7.45229238
3MP0005085_abnormal_gallbladder_physiolo6.47870869
4MP0005365_abnormal_bile_salt6.20458479
5MP0008875_abnormal_xenobiotic_pharmacok5.20571346
6MP0003806_abnormal_nucleotide_metabolis4.22582583
7MP0003252_abnormal_bile_duct3.93391216
8* MP0010329_abnormal_lipoprotein_level3.49728284
9MP0009840_abnormal_foam_cell3.39318070
10MP0005083_abnormal_biliary_tract3.11453794
11MP0003195_calcinosis2.83674474
12MP0005332_abnormal_amino_acid2.76213024
13MP0001666_abnormal_nutrient_absorption2.59121825
14MP0003191_abnormal_cellular_cholesterol2.35758445
15MP0000609_abnormal_liver_physiology2.17784735
16MP0004019_abnormal_vitamin_homeostasis2.13571949
17* MP0002118_abnormal_lipid_homeostasis2.09444194
18MP0002138_abnormal_hepatobiliary_system1.98750478
19MP0003868_abnormal_feces_composition1.94347906
20MP0005319_abnormal_enzyme/_coenzyme1.82770338
21MP0001764_abnormal_homeostasis1.66415374
22MP0009697_abnormal_copulation1.59084727
23MP0005584_abnormal_enzyme/coenzyme_acti1.56374828
24MP0005451_abnormal_body_composition1.53763306
25MP0003011_delayed_dark_adaptation1.39087933
26MP0002132_abnormal_respiratory_system1.28376223
27MP0003656_abnormal_erythrocyte_physiolo1.25814802
28MP0003186_abnormal_redox_activity1.25547541
29MP0009643_abnormal_urine_homeostasis1.20974933
30MP0000598_abnormal_liver_morphology1.17965011
31MP0003705_abnormal_hypodermis_morpholog1.14131579
32MP0005647_abnormal_sex_gland1.13184794
33MP0000604_amyloidosis1.10198050
34MP0009764_decreased_sensitivity_to1.06097863
35MP0001915_intracranial_hemorrhage1.02716676
36MP0009763_increased_sensitivity_to1.01880277
37MP0002254_reproductive_system_inflammat1.00378490
38MP0010368_abnormal_lymphatic_system0.93230633
39MP0005636_abnormal_mineral_homeostasis0.90512783
40MP0008469_abnormal_protein_level0.88381249
41MP0002282_abnormal_trachea_morphology0.87041077
42* MP0009642_abnormal_blood_homeostasis0.86108396
43MP0005670_abnormal_white_adipose0.84103783
44MP0005408_hypopigmentation0.82283786
45MP0006036_abnormal_mitochondrial_physio0.81951908
46MP0005376_homeostasis/metabolism_phenot0.79686499
47MP0009765_abnormal_xenobiotic_induced0.78476019
48MP0002078_abnormal_glucose_homeostasis0.78327502
49MP0000566_synostosis0.77839637
50MP0002876_abnormal_thyroid_physiology0.76850723
51MP0005084_abnormal_gallbladder_morpholo0.76696695
52MP0003879_abnormal_hair_cell0.74822224
53MP0002249_abnormal_larynx_morphology0.73549539
54MP0002971_abnormal_brown_adipose0.73438244
55MP0005220_abnormal_exocrine_pancreas0.70740627
56MP0005187_abnormal_penis_morphology0.70513891
57MP0005334_abnormal_fat_pad0.69849671
58MP0004130_abnormal_muscle_cell0.69181144
59MP0003690_abnormal_glial_cell0.68798549
60MP0005535_abnormal_body_temperature0.66848520
61MP0005266_abnormal_metabolism0.65089570
62MP0001661_extended_life_span0.64857886
63MP0009053_abnormal_anal_canal0.64593002
64MP0003329_amyloid_beta_deposits0.64178525
65MP0000639_abnormal_adrenal_gland0.61111990
66MP0001756_abnormal_urination0.58238634
67MP0006035_abnormal_mitochondrial_morpho0.57171464
68MP0005448_abnormal_energy_balance0.55908331
69MP0005464_abnormal_platelet_physiology0.53496502
70MP0002822_catalepsy0.51684877
71MP0005395_other_phenotype0.48600702
72MP0008874_decreased_physiological_sensi0.46859006
73MP0003638_abnormal_response/metabolism_0.46745661
74MP0002928_abnormal_bile_duct0.46119109
75MP0009785_altered_susceptibility_to0.45972668
76MP0003718_maternal_effect0.45781794
77MP0002089_abnormal_postnatal_growth/wei0.45117117
78MP0008873_increased_physiological_sensi0.45037728
79MP0005023_abnormal_wound_healing0.44243678
80MP0002136_abnormal_kidney_physiology0.44196514
81MP0002837_dystrophic_cardiac_calcinosis0.42815915
82MP0003724_increased_susceptibility_to0.42250853
83MP0003436_decreased_susceptibility_to0.42223825
84MP0004782_abnormal_surfactant_physiolog0.41811147
85MP0003075_altered_response_to0.40828446
86MP0003953_abnormal_hormone_level0.40632624
87MP0005248_abnormal_Harderian_gland0.40339846
88MP0005666_abnormal_adipose_tissue0.38703638
89MP0008872_abnormal_physiological_respon0.38411024
90MP0005166_decreased_susceptibility_to0.37150575
91MP0004381_abnormal_hair_follicle0.36836189
92MP0009672_abnormal_birth_weight0.35560387
93MP0000579_abnormal_nail_morphology0.33961123
94MP0009115_abnormal_fat_cell0.33124271
95MP0001243_abnormal_dermal_layer0.32781020
96MP0003172_abnormal_lysosome_physiology0.32687510
97MP0000249_abnormal_blood_vessel0.32498782
98MP0006082_CNS_inflammation0.31915228
99MP0000230_abnormal_systemic_arterial0.31890087
100MP0004883_abnormal_blood_vessel0.31871995
101MP0002796_impaired_skin_barrier0.31607044
102MP0002970_abnormal_white_adipose0.31366338
103MP0002168_other_aberrant_phenotype0.30957939
104MP0001853_heart_inflammation0.30785280
105MP0000467_abnormal_esophagus_morphology0.30109811
106MP0009384_cardiac_valve_regurgitation0.29315896
107MP0006292_abnormal_olfactory_placode0.28677172
108MP0001881_abnormal_mammary_gland0.27933653
109MP0001845_abnormal_inflammatory_respons0.27612732
110MP0002090_abnormal_vision0.25109713
111MP0005164_abnormal_response_to0.24827180
112MP0002060_abnormal_skin_morphology0.23727707
113MP0003122_maternal_imprinting0.23342124
114MP0004272_abnormal_basement_membrane0.22653101
115MP0005058_abnormal_lysosome_morphology0.21682737
116MP0002128_abnormal_blood_circulation0.21120392
117MP0005167_abnormal_blood-brain_barrier0.19567716
118MP0001851_eye_inflammation0.19203156
119MP0003878_abnormal_ear_physiology0.18379793
120MP0005377_hearing/vestibular/ear_phenot0.18379793
121MP0002332_abnormal_exercise_endurance0.18054671

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.58350082
2Deep venous thrombosis (HP:0002625)7.50689640
3Intrahepatic cholestasis (HP:0001406)7.28657549
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.84250076
5Prolonged partial thromboplastin time (HP:0003645)6.63086327
6Xanthomatosis (HP:0000991)6.42363271
7* Hypobetalipoproteinemia (HP:0003563)5.77185731
8Complement deficiency (HP:0004431)5.27653940
9* Hyperlipoproteinemia (HP:0010980)4.86876260
10Joint hemorrhage (HP:0005261)4.84129151
11Hyperammonemia (HP:0001987)4.67807202
12Epidermoid cyst (HP:0200040)4.60618349
13Abnormality of the common coagulation pathway (HP:0010990)4.50716190
14* Hypolipoproteinemia (HP:0010981)4.45220373
15Hyperglycinemia (HP:0002154)4.43606742
16Abnormality of methionine metabolism (HP:0010901)4.41946952
17Ketosis (HP:0001946)4.33061482
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.31097559
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22009077
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15117940
21Fat malabsorption (HP:0002630)4.11448518
22* Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.10937272
23Abnormality of pyrimidine metabolism (HP:0004353)3.94761216
24Hyperglycinuria (HP:0003108)3.91819358
25Hypoglycemic coma (HP:0001325)3.91264323
26Abnormality of glycine metabolism (HP:0010895)3.91199816
27Abnormality of serine family amino acid metabolism (HP:0010894)3.91199816
28Abnormality of complement system (HP:0005339)3.85005372
29Abnormality of the intrinsic pathway (HP:0010989)3.77782988
30Conjugated hyperbilirubinemia (HP:0002908)3.70065299
31Hypercholesterolemia (HP:0003124)3.68997381
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44601723
33* Hypoalphalipoproteinemia (HP:0003233)3.42580650
34Abnormality of fatty-acid metabolism (HP:0004359)3.39813397
35Hyperbilirubinemia (HP:0002904)3.37555781
36Spontaneous abortion (HP:0005268)3.12850521
37Delayed CNS myelination (HP:0002188)3.11732941
38Steatorrhea (HP:0002570)3.11221990
39Abnormality of nucleobase metabolism (HP:0010932)3.10987274
40Abnormality of serum amino acid levels (HP:0003112)3.10959877
41Ketoacidosis (HP:0001993)3.04613178
42Hepatocellular carcinoma (HP:0001402)3.01032726
43Myocardial infarction (HP:0001658)2.97670879
44Hypochromic microcytic anemia (HP:0004840)2.97124640
45Skin nodule (HP:0200036)2.83918707
46Metabolic acidosis (HP:0001942)2.79947192
47Purpura (HP:0000979)2.76199850
48Systemic lupus erythematosus (HP:0002725)2.69836619
49Abnormality of purine metabolism (HP:0004352)2.69100303
50Lethargy (HP:0001254)2.63908326
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61118655
52Dicarboxylic aciduria (HP:0003215)2.61118655
53Vascular calcification (HP:0004934)2.60170866
54Acanthocytosis (HP:0001927)2.51895435
55Hypoglycemic seizures (HP:0002173)2.51498019
56Spastic diplegia (HP:0001264)2.51270378
57Abnormal gallbladder morphology (HP:0012437)2.49184493
58Pulmonary embolism (HP:0002204)2.48783970
59Gout (HP:0001997)2.47106563
60Mitral stenosis (HP:0001718)2.46177737
61Cerebral edema (HP:0002181)2.45601635
62Glomerulonephritis (HP:0000099)2.44607619
63Cholelithiasis (HP:0001081)2.43478160
64Osteomalacia (HP:0002749)2.42049008
65Abnormal gallbladder physiology (HP:0012438)2.41182527
66Cholecystitis (HP:0001082)2.41182527
67Neonatal hypoglycemia (HP:0001998)2.39769802
68Irritability (HP:0000737)2.39536156
69Amyloidosis (HP:0011034)2.38598807
70Neonatal onset (HP:0003623)2.36326847
71Fair hair (HP:0002286)2.32511691
72Malnutrition (HP:0004395)2.30870972
73Cardiovascular calcification (HP:0011915)2.30654898
74Recurrent gram-negative bacterial infections (HP:0005420)2.27572096
75Gingival bleeding (HP:0000225)2.26869603
76Reduced antithrombin III activity (HP:0001976)2.21462388
77Brushfield spots (HP:0001088)2.20377425
78Esophageal varix (HP:0002040)2.19361137
79Menorrhagia (HP:0000132)2.17857211
80Late onset (HP:0003584)2.17020373
81Pancreatitis (HP:0001733)2.16057977
82Sensorimotor neuropathy (HP:0007141)2.15813592
83Enlarged kidneys (HP:0000105)2.14055622
84Thrombophlebitis (HP:0004418)2.12479002
85Vomiting (HP:0002013)2.09337122
86Arthropathy (HP:0003040)2.05847620
87Abnormality of the Achilles tendon (HP:0005109)2.05010623
88Opisthotonus (HP:0002179)2.04789596
89Hyperinsulinemic hypoglycemia (HP:0000825)2.04277782
90Generalized aminoaciduria (HP:0002909)2.03515953
91Hemorrhage of the eye (HP:0011885)2.02416726
92Abnormality of the gallbladder (HP:0005264)2.02092052
93Elevated alkaline phosphatase (HP:0003155)2.01770550
94Poikilocytosis (HP:0004447)2.01595926
95Abnormality of iron homeostasis (HP:0011031)1.96115586
96Rickets (HP:0002748)1.95759542
97Abnormality of transition element cation homeostasis (HP:0011030)1.91599122
98Gangrene (HP:0100758)1.91593193
99Increased serum ferritin (HP:0003281)1.91068774
100Abnormal cartilage morphology (HP:0002763)1.89610270
101Hypophosphatemic rickets (HP:0004912)1.88619185
102Renal cortical cysts (HP:0000803)1.87955976
103Abnormality of alkaline phosphatase activity (HP:0004379)1.87729527
104Epistaxis (HP:0000421)1.86605793
105Hydroxyprolinuria (HP:0003080)1.84296763
106Abnormality of proline metabolism (HP:0010907)1.84296763
107Elevated hepatic transaminases (HP:0002910)1.83398967
108Status epilepticus (HP:0002133)1.83316489
109Alkalosis (HP:0001948)1.82845884
110Joint swelling (HP:0001386)1.79578063
111Abnormal enzyme/coenzyme activity (HP:0012379)1.78285435
112Hyperglycemia (HP:0003074)1.76523389
113Abnormality of vitamin metabolism (HP:0100508)1.75497381
114Increased serum pyruvate (HP:0003542)1.74727398
115Nephritis (HP:0000123)1.73823644
116Bifid scrotum (HP:0000048)1.70665556
117Hyperphosphaturia (HP:0003109)1.66031153
118Increased mean platelet volume (HP:0011877)1.64244456
119Atrioventricular block (HP:0001678)1.58271454
120Reticulocytosis (HP:0001923)1.56645438
121Generalized hypopigmentation of hair (HP:0011358)1.56491266
122Abnormal biliary tract physiology (HP:0012439)1.53316153
123Bile duct proliferation (HP:0001408)1.53316153
124Abnormal platelet function (HP:0011869)1.52415893
125Impaired platelet aggregation (HP:0003540)1.52415893
126Abnormality of glycolysis (HP:0004366)1.51154367
127Abnormality of urine glucose concentration (HP:0011016)1.49861433
128Glycosuria (HP:0003076)1.49861433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24663015
2SIK14.63155346
3FGFR44.60714987
4ERN14.44515902
5TAOK33.03102866
6INSRR2.95436279
7ERBB42.88242362
8MAP2K42.38070985
9PKN22.31374411
10MST1R2.02577806
11FLT31.95539486
12MAPK111.86101555
13PIK3CG1.79145702
14TRIB31.76748471
15TYK21.67831577
16NTRK31.63190286
17LATS11.60239484
18DAPK21.55714213
19ABL21.50909095
20PTK61.45193716
21FGFR21.37530287
22NEK91.35933233
23KDR1.34487542
24FRK1.32086409
25PRPF4B1.27311833
26JAK21.22327523
27PINK11.18675727
28MAP3K71.18055039
29PRKAA21.12813828
30MAP2K31.08529473
31GRK61.08193385
32TBK11.07328097
33JAK11.01503034
34MAPK41.01210991
35ERBB21.00594917
36AKT31.00108605
37MAP3K140.98355100
38PDK20.97887302
39NLK0.96527739
40MAP3K100.95712179
41PRKCZ0.92668929
42MAPK150.91604108
43PDGFRA0.89593177
44PRKG10.88906938
45CDK120.86746391
46MAP3K30.86609025
47WNK40.85351133
48EPHB10.83458757
49MAPK120.83198007
50STK38L0.82420484
51CDK60.81516999
52MET0.80328627
53SMG10.79951324
54SGK10.79607291
55MAP3K110.79113316
56TIE10.77546032
57PRKACG0.76652336
58TNK20.76363790
59EPHA30.75487240
60CAMK2G0.73122624
61CSK0.72709448
62DYRK1B0.71794925
63MAP2K60.70585682
64PRKACA0.69622542
65MAP3K20.69352692
66CAMK1D0.69351837
67FGFR10.68826576
68GSK3A0.67611758
69FER0.65108482
70PRKAA10.64485404
71STK380.64005480
72IRAK30.63949438
73SGK30.63567224
74RIPK10.60740989
75MAPK70.59824116
76CSNK1D0.59237148
77TGFBR20.59188392
78FGFR30.56178538
79CSF1R0.55723492
80IKBKE0.54844939
81RPS6KA30.53979852
82PTK20.53645118
83EPHA40.52651645
84PDPK10.52400381
85CSNK1G10.52252266
86CSNK1E0.51910282
87PRKCQ0.51698544
88CAMKK10.48665372
89TAOK20.48349506
90PRKCB0.46484846
91SGK20.46112686
92SRC0.45216333
93GRK10.44624765
94MAP3K50.44363798
95IGF1R0.43224113
96MAP3K130.43209586
97RET0.42523818
98MAP2K10.41732304
99CDK40.41392355
100ZAP700.40969591
101SIK20.40865783
102PRKCG0.40684378
103CSNK2A10.39942325
104PKN10.39237862
105CAMKK20.38875639
106MAPKAPK30.38840171
107CSNK2A20.38338363
108ICK0.38245205
109PRKACB0.37487209
110MAP3K60.37024017
111MAPK30.35766239
112CAMK40.34835968
113MTOR0.34387776
114CSNK1G20.32817316
115PDK10.32616036
116PBK0.32500747
117EGFR0.32335319
118SGK2230.31154594
119SGK4940.31154594
120AKT20.30737388
121CSNK1G30.30524877
122EEF2K0.29687181
123MAPK100.28596865
124RPS6KB10.27710452
125MAP3K10.27680464
126LATS20.27278303
127IRAK20.26322692
128PRKCA0.25885892
129IRAK10.24638149
130CAMK1G0.23403431
131CSNK1A1L0.22007050
132PIK3CA0.21430554
133ABL10.21052673
134PDK30.20651881
135PDK40.20651881

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.52598503
2Nitrogen metabolism_Homo sapiens_hsa009103.55789963
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41727638
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37024378
5Arginine biosynthesis_Homo sapiens_hsa002203.09356084
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77967235
7Complement and coagulation cascades_Homo sapiens_hsa046102.74101796
8Tryptophan metabolism_Homo sapiens_hsa003802.68838505
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61052251
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53591086
11Fatty acid degradation_Homo sapiens_hsa000712.50097211
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37614089
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26302211
14Butanoate metabolism_Homo sapiens_hsa006502.14757333
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14403887
16Peroxisome_Homo sapiens_hsa041462.09535372
17Chemical carcinogenesis_Homo sapiens_hsa052041.96405984
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93910878
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.93068000
20Propanoate metabolism_Homo sapiens_hsa006401.91430207
21Histidine metabolism_Homo sapiens_hsa003401.90368213
22Fatty acid metabolism_Homo sapiens_hsa012121.82880450
23* PPAR signaling pathway_Homo sapiens_hsa033201.81411939
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.78103090
25Caffeine metabolism_Homo sapiens_hsa002321.75251973
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74868130
27Staphylococcus aureus infection_Homo sapiens_hsa051501.74817308
28Retinol metabolism_Homo sapiens_hsa008301.71754732
29beta-Alanine metabolism_Homo sapiens_hsa004101.71014818
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66845272
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61831096
32Phenylalanine metabolism_Homo sapiens_hsa003601.56867543
33Selenocompound metabolism_Homo sapiens_hsa004501.56811215
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51502294
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51270146
36Bile secretion_Homo sapiens_hsa049761.49372830
37Tyrosine metabolism_Homo sapiens_hsa003501.43993019
38Pyruvate metabolism_Homo sapiens_hsa006201.36974124
39Fatty acid elongation_Homo sapiens_hsa000621.36356594
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.33548082
41Sulfur metabolism_Homo sapiens_hsa009201.32174174
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27953026
43Folate biosynthesis_Homo sapiens_hsa007901.21940362
44Biosynthesis of amino acids_Homo sapiens_hsa012301.20665219
45ABC transporters_Homo sapiens_hsa020101.19172785
46Fat digestion and absorption_Homo sapiens_hsa049751.16351346
47Steroid biosynthesis_Homo sapiens_hsa001001.16215148
48Carbon metabolism_Homo sapiens_hsa012001.12135254
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04110418
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.01588641
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97964038
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97559257
53Arginine and proline metabolism_Homo sapiens_hsa003300.96424798
54Sulfur relay system_Homo sapiens_hsa041220.94577361
55Vitamin B6 metabolism_Homo sapiens_hsa007500.92086408
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87247981
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84396948
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84282805
59Lysine degradation_Homo sapiens_hsa003100.81332319
60One carbon pool by folate_Homo sapiens_hsa006700.75045601
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69888041
62Glycerolipid metabolism_Homo sapiens_hsa005610.67782511
63Glutathione metabolism_Homo sapiens_hsa004800.63931115
64Pentose phosphate pathway_Homo sapiens_hsa000300.56627846
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54025174
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46487567
67Metabolic pathways_Homo sapiens_hsa011000.45771786
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42597317
69Pertussis_Homo sapiens_hsa051330.42398835
70Prion diseases_Homo sapiens_hsa050200.33866967
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26448088
72Galactose metabolism_Homo sapiens_hsa000520.25403153
73Fructose and mannose metabolism_Homo sapiens_hsa000510.23655682
74Insulin resistance_Homo sapiens_hsa049310.23397395
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.22563357
76Linoleic acid metabolism_Homo sapiens_hsa005910.22226208
77Other glycan degradation_Homo sapiens_hsa005110.21456113
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18564831
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.16468213
80Glucagon signaling pathway_Homo sapiens_hsa049220.10966922
81AMPK signaling pathway_Homo sapiens_hsa041520.02494040
82Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2579730
83FoxO signaling pathway_Homo sapiens_hsa04068-0.2546743
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2505750
85Amoebiasis_Homo sapiens_hsa05146-0.2464462
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.2409315
87Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2407345
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2358424
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2242046
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2062307
91Renin-angiotensin system_Homo sapiens_hsa04614-0.1995261
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1979241
93Circadian rhythm_Homo sapiens_hsa04710-0.1939269
94Hepatitis C_Homo sapiens_hsa05160-0.1832131
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1776308
96N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1665764
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1655046
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1600553
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1591164
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1546602
101Regulation of autophagy_Homo sapiens_hsa04140-0.1401082
102African trypanosomiasis_Homo sapiens_hsa05143-0.1396243
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.1386024
104Insulin signaling pathway_Homo sapiens_hsa04910-0.0979233
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0940272
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0783262
107Serotonergic synapse_Homo sapiens_hsa04726-0.0763608
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0688489
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0381391
110Mineral absorption_Homo sapiens_hsa04978-0.0064860

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »