APOB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.21396542
2L-phenylalanine catabolic process (GO:0006559)7.21396542
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.87921074
4L-phenylalanine metabolic process (GO:0006558)6.87921074
5aromatic amino acid family catabolic process (GO:0009074)6.50151479
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.50089175
7* very-low-density lipoprotein particle assembly (GO:0034379)6.17953297
8urea cycle (GO:0000050)5.91297442
9urea metabolic process (GO:0019627)5.91297442
10indole-containing compound catabolic process (GO:0042436)5.87469670
11indolalkylamine catabolic process (GO:0046218)5.87469670
12tryptophan catabolic process (GO:0006569)5.87469670
13bile acid biosynthetic process (GO:0006699)5.86820099
14kynurenine metabolic process (GO:0070189)5.79826744
15alpha-linolenic acid metabolic process (GO:0036109)5.74596452
16* low-density lipoprotein particle remodeling (GO:0034374)5.66523916
17glyoxylate metabolic process (GO:0046487)5.56727682
18regulation of apoptotic cell clearance (GO:2000425)5.56277112
19tryptophan metabolic process (GO:0006568)5.55778977
20high-density lipoprotein particle remodeling (GO:0034375)5.55404786
21negative regulation of fibrinolysis (GO:0051918)5.46261499
22nitrogen cycle metabolic process (GO:0071941)5.41554512
23regulation of protein activation cascade (GO:2000257)5.38850921
24cysteine metabolic process (GO:0006534)5.38427865
25complement activation, alternative pathway (GO:0006957)5.34131510
26* protein-lipid complex subunit organization (GO:0071825)5.25412577
27regulation of fibrinolysis (GO:0051917)5.24859560
28positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.22139389
29protein carboxylation (GO:0018214)5.17129967
30peptidyl-glutamic acid carboxylation (GO:0017187)5.17129967
31sulfur amino acid catabolic process (GO:0000098)5.15584000
32regulation of cholesterol esterification (GO:0010872)5.10352297
33bile acid metabolic process (GO:0008206)5.09895795
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.08241041
35homocysteine metabolic process (GO:0050667)5.07671065
36regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.04623011
37regulation of complement activation (GO:0030449)5.02083629
38intestinal absorption (GO:0050892)5.00464997
39regulation of triglyceride catabolic process (GO:0010896)4.99267649
40reverse cholesterol transport (GO:0043691)4.99199183
41serine family amino acid catabolic process (GO:0009071)4.98431095
42regulation of plasminogen activation (GO:0010755)4.91909688
43phospholipid efflux (GO:0033700)4.89002033
44aromatic amino acid family metabolic process (GO:0009072)4.71845776
45negative regulation of cholesterol transport (GO:0032375)4.68799652
46negative regulation of sterol transport (GO:0032372)4.68799652
47diacylglycerol metabolic process (GO:0046339)4.64750963
48bile acid and bile salt transport (GO:0015721)4.64406135
49* plasma lipoprotein particle remodeling (GO:0034369)4.64145882
50* protein-lipid complex remodeling (GO:0034368)4.64145882
51* macromolecular complex remodeling (GO:0034367)4.64145882
52amino-acid betaine metabolic process (GO:0006577)4.63519423
53triglyceride homeostasis (GO:0070328)4.62725015
54acylglycerol homeostasis (GO:0055090)4.62725015
55lysine metabolic process (GO:0006553)4.59256109
56lysine catabolic process (GO:0006554)4.59256109
57tyrosine metabolic process (GO:0006570)4.58567552
58alpha-amino acid catabolic process (GO:1901606)4.50304201
59glycine metabolic process (GO:0006544)4.32587962
60cellular glucuronidation (GO:0052695)4.32346809
61* cholesterol efflux (GO:0033344)4.30917709
62cellular ketone body metabolic process (GO:0046950)4.23671999
63glutamate metabolic process (GO:0006536)4.21421249
64imidazole-containing compound metabolic process (GO:0052803)4.20586994
65indolalkylamine metabolic process (GO:0006586)4.17927340
66* plasma lipoprotein particle clearance (GO:0034381)4.17482922
67intestinal cholesterol absorption (GO:0030299)4.16343759
68coenzyme catabolic process (GO:0009109)4.14477445
69negative regulation of blood coagulation (GO:0030195)4.14393042
70negative regulation of hemostasis (GO:1900047)4.14393042
71cellular amino acid catabolic process (GO:0009063)4.14118684
72serine family amino acid metabolic process (GO:0009069)4.12890045
73drug catabolic process (GO:0042737)4.11772056
74phospholipid homeostasis (GO:0055091)4.10472357
75regulation of humoral immune response (GO:0002920)4.10258872
76acute-phase response (GO:0006953)4.06535588
77cellular biogenic amine catabolic process (GO:0042402)4.03164263
78amine catabolic process (GO:0009310)4.03164263
79* plasma lipoprotein particle assembly (GO:0034377)4.03073862
80dicarboxylic acid biosynthetic process (GO:0043650)4.02144123
81serine family amino acid biosynthetic process (GO:0009070)4.01399087
82regulation of bile acid biosynthetic process (GO:0070857)4.01092082
83cellular modified amino acid catabolic process (GO:0042219)3.99630714
84proline metabolic process (GO:0006560)3.99154625
85positive regulation of hemostasis (GO:1900048)3.98791755
86positive regulation of blood coagulation (GO:0030194)3.98791755
87positive regulation of lipoprotein lipase activity (GO:0051006)3.98540820
88positive regulation of triglyceride lipase activity (GO:0061365)3.98540820
89benzene-containing compound metabolic process (GO:0042537)3.98198458
90ethanol oxidation (GO:0006069)3.97352299
91positive regulation of lipid catabolic process (GO:0050996)3.95001876
92* cholesterol homeostasis (GO:0042632)3.89805225
93arginine metabolic process (GO:0006525)3.88632984
94fibrinolysis (GO:0042730)3.88538797
95positive regulation of steroid metabolic process (GO:0045940)3.86782366
96regulation of cholesterol homeostasis (GO:2000188)3.84561007
97positive regulation of extracellular matrix organization (GO:1903055)3.83516706
98* sterol homeostasis (GO:0055092)3.83330665
99uronic acid metabolic process (GO:0006063)3.82448284
100glucuronate metabolic process (GO:0019585)3.82448284
101negative regulation of coagulation (GO:0050819)3.82382265
102blood coagulation, intrinsic pathway (GO:0007597)3.77421743
103aldehyde catabolic process (GO:0046185)3.76978902
104* lipoprotein metabolic process (GO:0042157)3.70126210
105negative regulation of complement activation (GO:0045916)3.67627902
106epoxygenase P450 pathway (GO:0019373)3.66960990
107ketone body metabolic process (GO:1902224)3.66051946
108* cholesterol transport (GO:0030301)3.65673126
109* sterol transport (GO:0015918)3.65673126
110carboxylic acid catabolic process (GO:0046395)3.65650002
111organic acid catabolic process (GO:0016054)3.65650002
112protein activation cascade (GO:0072376)3.65591788
113flavonoid metabolic process (GO:0009812)3.65303612
114positive regulation of coagulation (GO:0050820)3.65005733
115complement activation, classical pathway (GO:0006958)3.64078678
116acetyl-CoA metabolic process (GO:0006084)3.63543207
117complement activation (GO:0006956)3.62937596
118positive regulation of fatty acid biosynthetic process (GO:0045723)3.62823743
119* protein-lipid complex assembly (GO:0065005)3.62793011
120negative regulation of lipase activity (GO:0060192)3.62582974
121negative regulation of protein activation cascade (GO:2000258)3.61482538
122negative regulation of wound healing (GO:0061045)3.60403560
123cofactor catabolic process (GO:0051187)3.60087021
124positive regulation of fatty acid beta-oxidation (GO:0032000)3.58968031
125* plasma lipoprotein particle organization (GO:0071827)3.58703069
126response to nitrosative stress (GO:0051409)3.55560313
127proline biosynthetic process (GO:0006561)3.41390496
128embryonic retina morphogenesis in camera-type eye (GO:0060059)3.36511505
129* lipid homeostasis (GO:0055088)3.29817377
130renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.23000684
131glutamine family amino acid biosynthetic process (GO:0009084)3.19558362
132angiotensin maturation (GO:0002003)3.17880371
133drug transmembrane transport (GO:0006855)3.15966271
134regulation of extracellular matrix organization (GO:1903053)3.15964766
135negative regulation of sodium ion transport (GO:0010766)3.14353388
136cytolysis (GO:0019835)3.12931139
137negative regulation of lipid transport (GO:0032369)3.12834495
138regulation of heterotypic cell-cell adhesion (GO:0034114)3.04583587
139modified amino acid transport (GO:0072337)3.04546430
140COPII vesicle coating (GO:0048208)3.03988047
141L-ascorbic acid metabolic process (GO:0019852)3.03243300
142drinking behavior (GO:0042756)3.01874469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.23828499
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09410357
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.94015975
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.53246327
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.17441986
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.87958167
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.55144028
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.14198237
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.75310263
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.07592456
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33197237
12AR_21909140_ChIP-Seq_LNCAP_Human2.20264170
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08686113
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07139695
15TCF4_18268006_ChIP-ChIP_LS174T_Human2.05637291
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6836436
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84281557
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81572353
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.72760057
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.71275530
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67213361
22CLOCK_20551151_ChIP-Seq_293T_Human1.65341282
23GATA1_22025678_ChIP-Seq_K562_Human1.57459467
24HTT_18923047_ChIP-ChIP_STHdh_Human1.53150157
25* HNF4A_19822575_ChIP-Seq_HepG2_Human1.50321936
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46844057
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27675268
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26991018
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22441287
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19727971
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.19582934
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18790992
33CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17846540
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16380130
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11722184
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11712462
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10505008
38GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10491652
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07811447
40GATA4_25053715_ChIP-Seq_YYC3_Human1.03792650
41RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98360554
42NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95618082
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94194758
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94040574
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90630009
46CDX2_20551321_ChIP-Seq_CACO-2_Human0.90433765
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89070055
48IRF8_22096565_ChIP-ChIP_GC-B_Human0.88437626
49POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87232887
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85588278
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85489318
52PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84704861
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83519812
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82778077
55SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82618705
56PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81869074
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79923866
58ESR2_21235772_ChIP-Seq_MCF-7_Human0.78428591
59ZNF263_19887448_ChIP-Seq_K562_Human0.76991233
60AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76782376
61SOX17_20123909_ChIP-Seq_XEN_Mouse0.75898707
62STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.75704503
63KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74236886
64RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72961391
65SMAD1_18555785_Chip-Seq_ESCs_Mouse0.72458931
66TP53_16413492_ChIP-PET_HCT116_Human0.72371598
67NANOG_21062744_ChIP-ChIP_HESCs_Human0.72185219
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72156765
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71683184
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71594790
71RARA_24833708_ChIP-Seq_LIVER_Mouse0.71269914
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.71097981
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70877742
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70877742
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70556809
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70262163
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70166439
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67583709
79AR_21572438_ChIP-Seq_LNCaP_Human0.67474716
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.67179250
81PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65461759
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.64682376
83SOX11_22085726_ChIP-Seq_ESNs_Mouse0.64083119
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63501766
85GATA6_25053715_ChIP-Seq_YYC3_Human0.61426999
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.60557463
87EGR1_19032775_ChIP-ChIP_M12_Human0.60413151
88ZFX_18555785_Chip-Seq_ESCs_Mouse0.59607974
89ESRRB_18555785_Chip-Seq_ESCs_Mouse0.59402332
90TP53_22127205_ChIP-Seq_IMR90_Human0.58673014
91CEBPB_22108803_ChIP-Seq_LS180_Human0.58270423
92* FOXA1_25552417_ChIP-Seq_VCAP_Human0.58253647
93ESR1_21235772_ChIP-Seq_MCF-7_Human0.57571332
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.57507337
95* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57348379
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57340191
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57302012
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57004433
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.56795700
100RARB_24833708_ChIP-Seq_LIVER_Mouse0.56445264
101TAF15_26573619_Chip-Seq_HEK293_Human0.55985328
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.55876637
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55757533
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.55464559
105CSB_26484114_Chip-Seq_FIBROBLAST_Human0.54950146
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.54902732
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54727918
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.54292735
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53856477
110* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52116954
111SOX2_20726797_ChIP-Seq_SW620_Human0.51912085
112CBP_21632823_ChIP-Seq_H3396_Human0.51594328
113* GATA2_19941826_ChIP-Seq_K562_Human0.51332012
114MYC_19915707_ChIP-ChIP_AK7_Human0.51274519
115GATA1_19941826_ChIP-Seq_K562_Human0.51056202
116* STAT1_17558387_ChIP-Seq_HELA_Human0.50399873
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50166526
118AR_20517297_ChIP-Seq_VCAP_Human0.50074095
119ESET_19884257_ChIP-Seq_ESCs_Mouse0.49695009
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.48262990
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48259160
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.47247157
123BCAT_22108803_ChIP-Seq_LS180_Human0.46485342
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46437466
125LXR_22292898_ChIP-Seq_THP-1_Human0.45756024
126P53_21459846_ChIP-Seq_SAOS-2_Human0.43895650
127CDX2_22108803_ChIP-Seq_LS180_Human0.42923645
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.42844860
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.41183171
130TAF2_19829295_ChIP-Seq_ESCs_Human0.40490437
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40423270
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.39986142
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.39498880
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39184970
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.38669748
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.37982304
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.37089333
138* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35297664
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.34338914
140ERG_20517297_ChIP-Seq_VCAP_Human0.34214467
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.34100499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.16273923
2MP0005360_urolithiasis7.97884854
3MP0005085_abnormal_gallbladder_physiolo6.47702944
4MP0005365_abnormal_bile_salt6.15278938
5MP0008875_abnormal_xenobiotic_pharmacok4.98110477
6MP0003122_maternal_imprinting4.31983453
7MP0003252_abnormal_bile_duct4.12412611
8MP0003806_abnormal_nucleotide_metabolis4.07445673
9* MP0010329_abnormal_lipoprotein_level3.52269709
10MP0009840_abnormal_foam_cell3.31553674
11MP0001666_abnormal_nutrient_absorption3.03467756
12MP0005083_abnormal_biliary_tract3.00460984
13MP0005332_abnormal_amino_acid2.66199205
14MP0003195_calcinosis2.56141202
15MP0003123_paternal_imprinting2.33653906
16MP0004019_abnormal_vitamin_homeostasis2.24691263
17MP0003191_abnormal_cellular_cholesterol2.23764258
18MP0000566_synostosis2.16308126
19* MP0000609_abnormal_liver_physiology2.13226033
20MP0002118_abnormal_lipid_homeostasis2.07235389
21MP0002138_abnormal_hepatobiliary_system1.97043529
22MP0002089_abnormal_postnatal_growth/wei1.92050608
23MP0003868_abnormal_feces_composition1.88662663
24MP0005319_abnormal_enzyme/_coenzyme1.76016800
25MP0005058_abnormal_lysosome_morphology1.74428331
26MP0001915_intracranial_hemorrhage1.72647906
27MP0009697_abnormal_copulation1.71029403
28MP0005409_darkened_coat_color1.69460613
29MP0006054_spinal_hemorrhage1.69042333
30MP0003172_abnormal_lysosome_physiology1.63819875
31MP0003183_abnormal_peptide_metabolism1.60454299
32MP0001764_abnormal_homeostasis1.59100974
33MP0005584_abnormal_enzyme/coenzyme_acti1.48630469
34MP0003121_genomic_imprinting1.35171794
35MP0005451_abnormal_body_composition1.34115129
36MP0002132_abnormal_respiratory_system1.30536291
37MP0004272_abnormal_basement_membrane1.29347005
38MP0003011_delayed_dark_adaptation1.27785901
39MP0009643_abnormal_urine_homeostasis1.23457201
40MP0003705_abnormal_hypodermis_morpholog1.22010830
41MP0002254_reproductive_system_inflammat1.19212274
42MP0003656_abnormal_erythrocyte_physiolo1.14196940
43* MP0000598_abnormal_liver_morphology1.13007421
44MP0009780_abnormal_chondrocyte_physiolo1.12051996
45MP0003186_abnormal_redox_activity1.08947317
46MP0000604_amyloidosis1.08244994
47MP0003950_abnormal_plasma_membrane1.05426132
48MP0005647_abnormal_sex_gland1.02475170
49MP0009764_decreased_sensitivity_to1.00810203
50MP0005084_abnormal_gallbladder_morpholo0.99533650
51MP0005257_abnormal_intraocular_pressure0.98822835
52MP0003315_abnormal_perineum_morphology0.96859825
53MP0009763_increased_sensitivity_to0.96769734
54MP0005636_abnormal_mineral_homeostasis0.92956565
55MP0010368_abnormal_lymphatic_system0.87547572
56MP0003941_abnormal_skin_development0.86273021
57MP0005167_abnormal_blood-brain_barrier0.86217644
58MP0003567_abnormal_fetal_cardiomyocyte0.85557550
59MP0008469_abnormal_protein_level0.85026735
60* MP0009642_abnormal_blood_homeostasis0.84270265
61MP0005408_hypopigmentation0.84209526
62MP0005376_homeostasis/metabolism_phenot0.79464822
63MP0009765_abnormal_xenobiotic_induced0.79338184
64MP0002938_white_spotting0.75625794
65* MP0002078_abnormal_glucose_homeostasis0.73694611
66MP0005220_abnormal_exocrine_pancreas0.73076162
67MP0001270_distended_abdomen0.72835446
68MP0002933_joint_inflammation0.72012090
69MP0009053_abnormal_anal_canal0.71658499
70MP0005076_abnormal_cell_differentiation0.71033632
71MP0002876_abnormal_thyroid_physiology0.70810025
72MP0002971_abnormal_brown_adipose0.69980235
73MP0006036_abnormal_mitochondrial_physio0.69334169
74MP0005334_abnormal_fat_pad0.67880320
75MP0005266_abnormal_metabolism0.67139283
76MP0001661_extended_life_span0.67090716
77MP0004130_abnormal_muscle_cell0.66547306
78MP0005448_abnormal_energy_balance0.65761149
79MP0003632_abnormal_nervous_system0.65394291
80MP0003890_abnormal_embryonic-extraembry0.64174387
81MP0005670_abnormal_white_adipose0.63843786
82MP0003943_abnormal_hepatobiliary_system0.63035473
83MP0003690_abnormal_glial_cell0.61746506
84MP0005535_abnormal_body_temperature0.61486468
85MP0002909_abnormal_adrenal_gland0.61261509
86MP0004264_abnormal_extraembryonic_tissu0.60597335
87MP0000920_abnormal_myelination0.60120828
88MP0003879_abnormal_hair_cell0.60096940
89MP0003329_amyloid_beta_deposits0.59935723
90MP0003115_abnormal_respiratory_system0.58034455
91MP0003566_abnormal_cell_adhesion0.57885092
92MP0001756_abnormal_urination0.57045814
93MP0005164_abnormal_response_to0.56633583
94MP0006035_abnormal_mitochondrial_morpho0.56353208
95MP0002822_catalepsy0.55240759
96MP0005464_abnormal_platelet_physiology0.55238805
97MP0000639_abnormal_adrenal_gland0.54849764
98MP0010234_abnormal_vibrissa_follicle0.54309921
99MP0005023_abnormal_wound_healing0.51999957
100MP0003942_abnormal_urinary_system0.51739379
101MP0000003_abnormal_adipose_tissue0.49492578
102MP0002136_abnormal_kidney_physiology0.48730203
103MP0009384_cardiac_valve_regurgitation0.48279288
104MP0003718_maternal_effect0.48039555
105MP0002928_abnormal_bile_duct0.47704371
106MP0003878_abnormal_ear_physiology0.47542262
107MP0005377_hearing/vestibular/ear_phenot0.47542262
108MP0005395_other_phenotype0.45872283
109MP0008260_abnormal_autophagy0.44851151
110MP0002697_abnormal_eye_size0.44730431
111MP0003638_abnormal_response/metabolism_0.44062859
112MP0008873_increased_physiological_sensi0.43587650
113MP0001730_embryonic_growth_arrest0.43216307
114MP0002092_abnormal_eye_morphology0.42740449
115MP0002796_impaired_skin_barrier0.42429843
116MP0000858_altered_metastatic_potential0.41930108
117MP0002166_altered_tumor_susceptibility0.40717039
118MP0000579_abnormal_nail_morphology0.40118562
119MP0003699_abnormal_female_reproductive0.39663789
120MP0005248_abnormal_Harderian_gland0.39637878
121MP0005166_decreased_susceptibility_to0.38177109
122* MP0002086_abnormal_extraembryonic_tissu0.37801388
123* MP0003953_abnormal_hormone_level0.37532519
124MP0008874_decreased_physiological_sensi0.37246315
125MP0003436_decreased_susceptibility_to0.37237849
126MP0003724_increased_susceptibility_to0.37168587
127MP0000371_diluted_coat_color0.36483757
128MP0004782_abnormal_surfactant_physiolog0.36291669
129MP0004381_abnormal_hair_follicle0.36144359
130MP0005666_abnormal_adipose_tissue0.35483660
131MP0000427_abnormal_hair_cycle0.33989835
132MP0000230_abnormal_systemic_arterial0.33548015
133MP0009115_abnormal_fat_cell0.33522888
134MP0003075_altered_response_to0.33448762
135MP0001881_abnormal_mammary_gland0.32784152
136MP0008872_abnormal_physiological_respon0.32515478
137MP0009672_abnormal_birth_weight0.31914109
138MP0000249_abnormal_blood_vessel0.31198322
139MP0004883_abnormal_blood_vessel0.30252176
140MP0001243_abnormal_dermal_layer0.29965207
141MP0003300_gastrointestinal_ulcer0.29069159
142MP0001853_heart_inflammation0.27442795
143MP0001845_abnormal_inflammatory_respons0.27107076
144MP0002060_abnormal_skin_morphology0.27100143
145MP0004043_abnormal_pH_regulation0.27004353
146MP0002970_abnormal_white_adipose0.26540379
147MP0006082_CNS_inflammation0.26440451

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.61929972
2Deep venous thrombosis (HP:0002625)7.31491865
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.95111685
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75676291
5Prolonged partial thromboplastin time (HP:0003645)6.55497787
6* Hypobetalipoproteinemia (HP:0003563)6.25001191
7* Xanthomatosis (HP:0000991)6.05438427
8Complement deficiency (HP:0004431)5.41117560
9Hyperlipoproteinemia (HP:0010980)5.18626601
10Joint hemorrhage (HP:0005261)4.71865021
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.70766101
12* Hypolipoproteinemia (HP:0010981)4.66217584
13Abnormality of the common coagulation pathway (HP:0010990)4.63074954
14Hyperammonemia (HP:0001987)4.60499994
15Conjugated hyperbilirubinemia (HP:0002908)4.40338378
16Hyperglycinemia (HP:0002154)4.32022488
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.27933581
18* Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25961636
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22833352
20Hypoalphalipoproteinemia (HP:0003233)4.17874307
21* Fat malabsorption (HP:0002630)4.15434819
22Abnormality of methionine metabolism (HP:0010901)4.12381077
23Ketosis (HP:0001946)4.07246134
24Hyperglycinuria (HP:0003108)4.03532205
25Abnormality of serine family amino acid metabolism (HP:0010894)3.97397398
26Abnormality of glycine metabolism (HP:0010895)3.97397398
27* Epidermoid cyst (HP:0200040)3.97209291
28Hypoglycemic coma (HP:0001325)3.95725511
29Abnormality of complement system (HP:0005339)3.93896219
30Abnormality of pyrimidine metabolism (HP:0004353)3.79325670
31Abnormality of the intrinsic pathway (HP:0010989)3.74787860
32Abnormality of carpal bone ossification (HP:0006257)3.57786179
33Small epiphyses (HP:0010585)3.55220127
34Abnormal tarsal ossification (HP:0008369)3.50061759
35Hyperbilirubinemia (HP:0002904)3.44154142
36* Hypercholesterolemia (HP:0003124)3.41714426
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29581580
38Flat acetabular roof (HP:0003180)3.23778879
39Abnormality of fatty-acid metabolism (HP:0004359)3.18957654
40Abnormality of nucleobase metabolism (HP:0010932)3.09774829
41Spontaneous abortion (HP:0005268)3.08230201
42Steatorrhea (HP:0002570)3.08208222
43Hepatocellular carcinoma (HP:0001402)3.02601652
44Broad alveolar ridges (HP:0000187)3.01491806
45Ketoacidosis (HP:0001993)2.97256706
46Abnormality of serum amino acid levels (HP:0003112)2.95822023
47Myocardial infarction (HP:0001658)2.95743658
48Hypochromic microcytic anemia (HP:0004840)2.93513254
49Delayed CNS myelination (HP:0002188)2.92377838
50Pancreatic islet-cell hyperplasia (HP:0004510)2.80515395
51Broad palm (HP:0001169)2.79970440
52Purpura (HP:0000979)2.79827099
53Hypophosphatemic rickets (HP:0004912)2.78916227
54Metabolic acidosis (HP:0001942)2.76335864
55Abnormality of purine metabolism (HP:0004352)2.74999409
56Hypoglycemic seizures (HP:0002173)2.70977982
57Systemic lupus erythematosus (HP:0002725)2.70761573
58Osteomalacia (HP:0002749)2.67604764
59Abnormal hand bone ossification (HP:0010660)2.66902821
60Malnutrition (HP:0004395)2.64568496
61Abnormal ossification of hand bones (HP:0005921)2.64422797
62Hepatoblastoma (HP:0002884)2.61035569
63Glomerulonephritis (HP:0000099)2.54881300
64Vascular calcification (HP:0004934)2.54310715
65Lethargy (HP:0001254)2.52082004
66Abnormality of the nasal septum (HP:0000419)2.51834469
67Potter facies (HP:0002009)2.51660649
68Facial shape deformation (HP:0011334)2.51660649
69Abnormal gallbladder morphology (HP:0012437)2.51517072
70Spastic diplegia (HP:0001264)2.49601342
71Increased serum pyruvate (HP:0003542)2.49283138
72Epiphyseal dysplasia (HP:0002656)2.48201099
73Cholecystitis (HP:0001082)2.46046447
74Abnormal gallbladder physiology (HP:0012438)2.46046447
75Cholelithiasis (HP:0001081)2.45244265
76Abnormality of the lumbar spine (HP:0100712)2.41531924
77Dicarboxylic aciduria (HP:0003215)2.40467157
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40467157
79Esophageal varix (HP:0002040)2.37869214
80Irritability (HP:0000737)2.34372800
81Widely patent fontanelles and sutures (HP:0004492)2.32406680
82Cerebral edema (HP:0002181)2.31978667
83* Skin nodule (HP:0200036)2.31835995
84Arthropathy (HP:0003040)2.31349077
85Pigmentary retinal degeneration (HP:0001146)2.30633465
86Abnormality of glycolysis (HP:0004366)2.30285840
87Abnormal foot bone ossification (HP:0010675)2.30250137
88Amyloidosis (HP:0011034)2.29951474
89* Acanthocytosis (HP:0001927)2.29868079
90Gout (HP:0001997)2.29844616
91Gingival bleeding (HP:0000225)2.27787157
92Mitral stenosis (HP:0001718)2.26470631
93Recurrent gram-negative bacterial infections (HP:0005420)2.25328418
94Cardiovascular calcification (HP:0011915)2.25271915
95Hyperinsulinemic hypoglycemia (HP:0000825)2.21065035
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21060647
97Neonatal onset (HP:0003623)2.19784345
98Hydroxyprolinuria (HP:0003080)2.19510671
99Abnormality of proline metabolism (HP:0010907)2.19510671
100Sensorimotor neuropathy (HP:0007141)2.19201216
101Vaginal fistula (HP:0004320)2.18781030
102Pancreatitis (HP:0001733)2.17089361
103Diastasis recti (HP:0001540)2.16198144
104Alacrima (HP:0000522)2.13690363
105Abnormality of the wing of the ilium (HP:0011867)2.13308143
106Flared iliac wings (HP:0002869)2.12074292
107Late onset (HP:0003584)2.11305754
108Menorrhagia (HP:0000132)2.11033444
109Enlarged kidneys (HP:0000105)2.05366982
110Thrombophlebitis (HP:0004418)2.04997377
111Irregular epiphyses (HP:0010582)2.04987066
112Brushfield spots (HP:0001088)2.02031354
113Cupped ribs (HP:0000887)2.01506474
114* Poikilocytosis (HP:0004447)2.01360017
115Abnormality of the gallbladder (HP:0005264)2.00504698
116Asymmetry of the thorax (HP:0001555)2.00490270
117Proximal tubulopathy (HP:0000114)1.99352173
118Rickets (HP:0002748)1.99254973
119Hemorrhage of the eye (HP:0011885)1.99099522
120Abnormality of transition element cation homeostasis (HP:0011030)1.98091994
121Vomiting (HP:0002013)1.97364915
122Abnormality of vitamin metabolism (HP:0100508)1.96538810
123Generalized aminoaciduria (HP:0002909)1.92911240
124Metaphyseal irregularity (HP:0003025)1.92239444
125Abnormality of iron homeostasis (HP:0011031)1.91977647
126Opisthotonus (HP:0002179)1.90056279
127Abnormal cartilage morphology (HP:0002763)1.88968110
128Nephritis (HP:0000123)1.88392222
129Abnormal delivery (HP:0001787)1.87563924
130Alkalosis (HP:0001948)1.87297291
131Abnormal enzyme/coenzyme activity (HP:0012379)1.87063254
132Confusion (HP:0001289)1.86533709
133Symptomatic seizures (HP:0011145)1.85501231
134Glycosuria (HP:0003076)1.85095807
135Abnormality of urine glucose concentration (HP:0011016)1.85095807
136Hyperglycemia (HP:0003074)1.83020404
137Neonatal death (HP:0003811)1.83018874
138Absent epiphyses (HP:0010577)1.81966747
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81966747
140Abnormality of the acetabulum (HP:0003170)1.81876178
141Joint swelling (HP:0001386)1.77815931
142Wide nose (HP:0000445)1.76908937
143Limited elbow extension (HP:0001377)1.76218614
144Wide cranial sutures (HP:0010537)1.75415906
145Prenatal maternal abnormality (HP:0002686)1.70301016
146Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69262677
147Abnormality of the Achilles tendon (HP:0005109)1.69197799
148Abnormality of endocrine pancreas physiology (HP:0012093)1.68176917
149Abnormality of the pancreatic islet cells (HP:0006476)1.68176917
150Peritonitis (HP:0002586)1.66781798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.10080768
2SIK14.49304482
3FGFR44.16919174
4ERN13.71440449
5INSRR3.42978678
6TAOK33.20960141
7ERBB43.18883249
8WNK43.09535724
9CDK123.08490083
10FRK2.88729797
11MST1R2.83538564
12TYRO32.64441821
13FGFR12.29661602
14MAP2K42.14686680
15LATS12.11618191
16PKN22.07732505
17MAPK112.04452822
18PIK3CG1.97719461
19FLT31.78855299
20PTK61.76125321
21TYK21.65583192
22MAP3K101.59528389
23FGFR21.54895582
24WNK11.52818034
25EEF2K1.52332936
26DAPK21.45194597
27GRK61.42317398
28MAP3K71.39600745
29TRIB31.39241253
30NEK91.37982820
31EIF2AK11.33869992
32ABL21.31299305
33PRKAA21.28550470
34ERBB21.27599055
35KDR1.24480675
36DDR21.23196108
37JAK21.21391714
38SIK21.18681568
39MET1.18342669
40RIPK11.16255356
41STK391.13721340
42JAK11.06496762
43PDK21.03465050
44ACVR1B1.01961832
45CAMK1D0.98915706
46LATS20.98488327
47TBK10.97940742
48MAPK40.95126545
49CDK70.93697750
50MAP3K140.89591701
51EPHB10.88923714
52NEK10.86420791
53PINK10.85673090
54FGR0.84426167
55PRKCZ0.84384625
56RPS6KB10.83080106
57MAP3K30.83067651
58KSR20.81815707
59CDK60.81765371
60CSNK1E0.79896715
61MAPKAPK30.79278897
62MAP2K30.79242811
63PRKAA10.77145376
64AKT30.76308053
65PRKACG0.75835480
66STK38L0.75572725
67EPHA30.71583969
68FGFR30.70603683
69BRSK20.70055855
70SGK30.69108504
71GSK3A0.68813859
72CAMK2G0.67748813
73SGK10.67268908
74CSK0.67101744
75DYRK1B0.67021761
76NEK20.66012565
77CDC42BPA0.64911615
78PTK20.64735904
79BCR0.64610612
80MAP3K20.63396397
81BRSK10.62824565
82SCYL20.62612997
83MAPK120.62054615
84SMG10.61291409
85TIE10.60359677
86MAP3K110.60245808
87BRD40.58897589
88CSF1R0.58148044
89EPHA20.57415284
90MAP2K60.55022680
91PRKCQ0.55012975
92MAPK150.54859190
93PDPK10.53192852
94NTRK30.51726630
95IRAK30.50204319
96NUAK10.50052254
97GRK10.49825230
98MATK0.49756373
99MAPK70.48179956
100SGK20.47353052
101IGF1R0.47016108
102CSNK1G10.46151111
103MAP2K10.45323469
104MAP3K10.45165296
105YES10.44742011
106TGFBR20.44660547
107RET0.43438978
108PIK3CA0.42920659
109IKBKE0.42919997
110SRC0.41932393
111ICK0.40888356
112PKN10.40450788
113CDK80.40223113
114MAP3K50.39199013
115CAMK1G0.38633914
116MTOR0.38628814
117CSNK1D0.38276692
118MELK0.38205623
119EGFR0.38061672
120NLK0.37502843
121MAP2K20.37154802
122PRKG20.37152047
123PBK0.36791345
124BMX0.35984066
125CDK40.35451136
126PDK10.35180570
127CSNK2A20.35122776
128PDGFRB0.33889868
129LMTK20.33753108
130STK30.33710033
131PAK30.32678941
132SGK4940.30446409
133SGK2230.30446409
134RPS6KA30.29010639
135CSNK2A10.28444773
136PRKCA0.28371934
137MAP3K60.28191775
138MAP3K130.27819068
139PRKG10.27551153
140EPHA40.26648284
141EIF2AK30.25665888
142ALK0.25651010
143PDGFRA0.25165047
144NTRK20.24301247
145CAMK40.23740167
146PRKCG0.23465240
147ABL10.22723506

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37069934
2Nitrogen metabolism_Homo sapiens_hsa009104.13269152
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33620077
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25338860
5Arginine biosynthesis_Homo sapiens_hsa002203.10914032
6Complement and coagulation cascades_Homo sapiens_hsa046102.71452343
7Tryptophan metabolism_Homo sapiens_hsa003802.66689152
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62453488
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52286387
10Fatty acid degradation_Homo sapiens_hsa000712.50553963
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45256595
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29014381
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20668669
14Butanoate metabolism_Homo sapiens_hsa006502.09176620
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06410485
16Peroxisome_Homo sapiens_hsa041462.02070697
17Histidine metabolism_Homo sapiens_hsa003401.95652963
18PPAR signaling pathway_Homo sapiens_hsa033201.91311020
19Propanoate metabolism_Homo sapiens_hsa006401.86624308
20Chemical carcinogenesis_Homo sapiens_hsa052041.83906314
21Caffeine metabolism_Homo sapiens_hsa002321.82645036
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82572080
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.81922394
24Fatty acid metabolism_Homo sapiens_hsa012121.79812595
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73193018
26beta-Alanine metabolism_Homo sapiens_hsa004101.72369262
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.71971741
28Staphylococcus aureus infection_Homo sapiens_hsa051501.71308945
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69528971
30Retinol metabolism_Homo sapiens_hsa008301.65890207
31Bile secretion_Homo sapiens_hsa049761.61097887
32Selenocompound metabolism_Homo sapiens_hsa004501.55776302
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49791030
34Phenylalanine metabolism_Homo sapiens_hsa003601.48930290
35Starch and sucrose metabolism_Homo sapiens_hsa005001.46683197
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46176318
37* Fat digestion and absorption_Homo sapiens_hsa049751.42771928
38Other glycan degradation_Homo sapiens_hsa005111.40062219
39Sulfur metabolism_Homo sapiens_hsa009201.37818559
40Tyrosine metabolism_Homo sapiens_hsa003501.34866933
41ABC transporters_Homo sapiens_hsa020101.34615713
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33980778
43Pyruvate metabolism_Homo sapiens_hsa006201.32564652
44Fatty acid elongation_Homo sapiens_hsa000621.29569930
45Folate biosynthesis_Homo sapiens_hsa007901.23013658
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.22248301
47Biosynthesis of amino acids_Homo sapiens_hsa012301.18406395
48Steroid biosynthesis_Homo sapiens_hsa001001.15767180
49Carbon metabolism_Homo sapiens_hsa012001.13972939
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.12302214
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98324458
52Arginine and proline metabolism_Homo sapiens_hsa003300.95844710
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95529585
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94492660
55* Vitamin digestion and absorption_Homo sapiens_hsa049770.93120563
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92932444
57Vitamin B6 metabolism_Homo sapiens_hsa007500.89920652
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88993143
59Lysine degradation_Homo sapiens_hsa003100.85537159
60N-Glycan biosynthesis_Homo sapiens_hsa005100.84271645
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78029700
62Sulfur relay system_Homo sapiens_hsa041220.77314191
63Glycerolipid metabolism_Homo sapiens_hsa005610.74997048
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73315326
65Glutathione metabolism_Homo sapiens_hsa004800.68982400
66One carbon pool by folate_Homo sapiens_hsa006700.68965280
67Fatty acid biosynthesis_Homo sapiens_hsa000610.63460988
68Pentose phosphate pathway_Homo sapiens_hsa000300.57888483
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50197245
70Galactose metabolism_Homo sapiens_hsa000520.49029136
71Pertussis_Homo sapiens_hsa051330.44055853
72Metabolic pathways_Homo sapiens_hsa011000.43786890
73Sphingolipid metabolism_Homo sapiens_hsa006000.40352353
74Fructose and mannose metabolism_Homo sapiens_hsa000510.32368320
75Prion diseases_Homo sapiens_hsa050200.29840225
76Insulin resistance_Homo sapiens_hsa049310.26162580
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25043305
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.23171974
79ECM-receptor interaction_Homo sapiens_hsa045120.19457755
80Renin-angiotensin system_Homo sapiens_hsa046140.19110881
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.17722997
82Linoleic acid metabolism_Homo sapiens_hsa005910.14874122
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13200567
84Ether lipid metabolism_Homo sapiens_hsa005650.11825685
85Glucagon signaling pathway_Homo sapiens_hsa049220.09425992
86AMPK signaling pathway_Homo sapiens_hsa041520.02387206
87Non-small cell lung cancer_Homo sapiens_hsa052230.01544188
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01499097
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.01445439
90HIF-1 signaling pathway_Homo sapiens_hsa040660.01177292
91Mineral absorption_Homo sapiens_hsa049780.00189437
92Amoebiasis_Homo sapiens_hsa05146-0.2247016
93Regulation of autophagy_Homo sapiens_hsa04140-0.2213943
94Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2115133
95Bladder cancer_Homo sapiens_hsa05219-0.2052126
96Type II diabetes mellitus_Homo sapiens_hsa04930-0.2003574
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1925202
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1808242
99Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1521083
100African trypanosomiasis_Homo sapiens_hsa05143-0.1502720
101Hepatitis C_Homo sapiens_hsa05160-0.1481516
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1318904
103Protein digestion and absorption_Homo sapiens_hsa04974-0.1260634
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1196753
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1115942
106Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1066355
107Insulin signaling pathway_Homo sapiens_hsa04910-0.0872963
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0805534
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0444800
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0159426

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