APOBEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.75282981
2regulation of guanylate cyclase activity (GO:0031282)7.97297314
3NADH metabolic process (GO:0006734)7.13273959
4regulation of bile acid biosynthetic process (GO:0070857)7.00545444
5epoxygenase P450 pathway (GO:0019373)6.82474482
6intestinal absorption (GO:0050892)6.71210958
7fat-soluble vitamin biosynthetic process (GO:0042362)6.63153589
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.46087053
9positive regulation of guanylate cyclase activity (GO:0031284)6.38590512
10modulation by symbiont of host defense response (GO:0052031)6.34967099
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.34967099
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.34967099
13positive regulation by organism of defense response of other organism involved in symbiotic interact6.34967099
14modulation by symbiont of host immune response (GO:0052553)6.34967099
15positive regulation by symbiont of host defense response (GO:0052509)6.34967099
16fructose metabolic process (GO:0006000)5.73972406
17regulation of interferon-beta biosynthetic process (GO:0045357)5.64260787
18* lipoprotein transport (GO:0042953)5.49823499
19neutrophil activation involved in immune response (GO:0002283)5.47180448
20regulation of systemic arterial blood pressure by hormone (GO:0001990)5.42363265
21regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.42363265
22endocrine process (GO:0050886)5.42363265
23hormone catabolic process (GO:0042447)5.34488932
24regulation of cellular extravasation (GO:0002691)5.27554861
25virion attachment to host cell (GO:0019062)5.14317315
26adhesion of symbiont to host cell (GO:0044650)5.14317315
27immunoglobulin mediated immune response (GO:0016064)5.07329004
28macrophage activation involved in immune response (GO:0002281)5.02224444
29vitamin A metabolic process (GO:0006776)5.00146428
30cellular glucuronidation (GO:0052695)4.99078567
31regulation of triglyceride catabolic process (GO:0010896)4.95858681
32glucuronate metabolic process (GO:0019585)4.92959850
33uronic acid metabolic process (GO:0006063)4.92959850
34drug metabolic process (GO:0017144)4.90635816
35positive regulation of interferon-alpha production (GO:0032727)4.87872619
36regulation of systemic arterial blood pressure (GO:0003073)4.87449386
37regulation of cGMP biosynthetic process (GO:0030826)4.83299389
38bile acid and bile salt transport (GO:0015721)4.82017181
39urea cycle (GO:0000050)4.74166762
40regulation of B cell receptor signaling pathway (GO:0050855)4.62684818
41very-low-density lipoprotein particle assembly (GO:0034379)4.61887916
42digestion (GO:0007586)4.59507016
43regulation of interferon-alpha production (GO:0032647)4.59120436
44response to peptidoglycan (GO:0032494)4.54199599
45peptide hormone processing (GO:0016486)4.52080381
46urea metabolic process (GO:0019627)4.51291818
47receptor guanylyl cyclase signaling pathway (GO:0007168)4.49368707
48diacylglycerol metabolic process (GO:0046339)4.49138893
49antibacterial humoral response (GO:0019731)4.39473775
50adhesion of symbiont to host (GO:0044406)4.35666768
51glycolipid catabolic process (GO:0019377)4.32847832
52flavonoid metabolic process (GO:0009812)4.28346189
53glycosphingolipid catabolic process (GO:0046479)4.28193821
54antimicrobial humoral response (GO:0019730)4.24895444
55nitrogen cycle metabolic process (GO:0071941)4.17319833
56plasma lipoprotein particle assembly (GO:0034377)4.17254238
57regulation of vitamin metabolic process (GO:0030656)4.15591483
58renal system process involved in regulation of blood volume (GO:0001977)4.13457839
59positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.11789727
60response to host immune response (GO:0052572)4.09776145
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.09776145
62microglial cell activation (GO:0001774)4.07708364
63peptide catabolic process (GO:0043171)4.06115992
64regulation of cGMP metabolic process (GO:0030823)4.02400373
65positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.99540265
66positive regulation of antigen processing and presentation (GO:0002579)3.98832991
67maintenance of gastrointestinal epithelium (GO:0030277)3.95321864
68drinking behavior (GO:0042756)3.95047565
69fat-soluble vitamin metabolic process (GO:0006775)3.91327788
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.88544792
71positive regulation of pseudopodium assembly (GO:0031274)3.88128620
72alkaloid metabolic process (GO:0009820)3.86506402
73positive regulation of glycoprotein biosynthetic process (GO:0010560)3.83815969
74B cell mediated immunity (GO:0019724)3.81524033
75protein-lipid complex assembly (GO:0065005)3.80495635
76neutrophil activation (GO:0042119)3.78970366
77cellular response to nitric oxide (GO:0071732)3.78594416
78natural killer cell mediated immunity (GO:0002228)3.77262971
79natural killer cell mediated cytotoxicity (GO:0042267)3.77262971
80granulocyte activation (GO:0036230)3.76216421
81antigen processing and presentation of endogenous antigen (GO:0019883)3.73589335
82myeloid cell activation involved in immune response (GO:0002275)3.71583176
83positive regulation of cGMP biosynthetic process (GO:0030828)3.68867569
84drug catabolic process (GO:0042737)3.68590907
85response to host (GO:0075136)3.67098813
86response to host defenses (GO:0052200)3.67098813
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.67098813
88vitamin transmembrane transport (GO:0035461)3.66860253
89vitamin transport (GO:0051180)3.64330397
90daunorubicin metabolic process (GO:0044597)3.61083506
91polyketide metabolic process (GO:0030638)3.61083506
92doxorubicin metabolic process (GO:0044598)3.61083506
93glutamine family amino acid biosynthetic process (GO:0009084)3.59921409
94homocysteine metabolic process (GO:0050667)3.58592770
95arginine metabolic process (GO:0006525)3.57528868
96macrophage activation (GO:0042116)3.55667759
97respiratory burst (GO:0045730)3.52923700
98positive regulation of gamma-delta T cell activation (GO:0046645)3.50234704
99midgut development (GO:0007494)3.49590527
100exogenous drug catabolic process (GO:0042738)3.48391705
101sulfate transmembrane transport (GO:1902358)3.48253526
102regulation of pseudopodium assembly (GO:0031272)3.47736767
103regulation of antigen processing and presentation (GO:0002577)3.47418832
104pinocytosis (GO:0006907)3.46402196
105phospholipid efflux (GO:0033700)3.45981828
106ceramide catabolic process (GO:0046514)3.45905635
107positive regulation of glycoprotein metabolic process (GO:1903020)3.45606800
108bile acid metabolic process (GO:0008206)3.44528971
109cGMP biosynthetic process (GO:0006182)3.42510669
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.42234810
111nucleoside diphosphate biosynthetic process (GO:0009133)3.42023503
112regulation of cholesterol homeostasis (GO:2000188)3.41655054
113positive regulation of interferon-beta production (GO:0032728)3.40334759
114B cell receptor signaling pathway (GO:0050853)3.37941732
115positive regulation of B cell differentiation (GO:0045579)3.37508525
116response to nitric oxide (GO:0071731)3.37415691
117vitamin biosynthetic process (GO:0009110)3.35566984
118glycosylceramide metabolic process (GO:0006677)3.35102788
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31760656
120antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31760656
121response to muramyl dipeptide (GO:0032495)3.30406528
122cellular response to reactive nitrogen species (GO:1902170)3.30124799
123digestive system process (GO:0022600)3.29732884
124regulation of cholesterol esterification (GO:0010872)3.29480570
125positive regulation of lipoprotein lipase activity (GO:0051006)3.28977796
126positive regulation of triglyceride lipase activity (GO:0061365)3.28977796
127sphingolipid catabolic process (GO:0030149)3.24468675
128phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.24007461
129T-helper 1 type immune response (GO:0042088)3.23814623
130response to type I interferon (GO:0034340)3.23294043
131drug transport (GO:0015893)3.22863107
132type I interferon signaling pathway (GO:0060337)3.22459840
133cellular response to type I interferon (GO:0071357)3.22459840
134citrulline biosynthetic process (GO:0019240)3.21438296
135positive regulation of cGMP metabolic process (GO:0030825)3.21289519
136sphingomyelin metabolic process (GO:0006684)3.20855327
137regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18043146
138positive regulation of lipid catabolic process (GO:0050996)3.17479119
139cobalamin metabolic process (GO:0009235)3.16975090
140regulation of protein glycosylation (GO:0060049)3.14137701
141glycoside metabolic process (GO:0016137)3.14058861
142interferon-gamma-mediated signaling pathway (GO:0060333)3.13354974
143glycerol metabolic process (GO:0006071)3.11867508
144membrane lipid catabolic process (GO:0046466)3.11191909
145transcytosis (GO:0045056)3.10870708
146vitamin D metabolic process (GO:0042359)3.10633141
147* lipoprotein metabolic process (GO:0042157)3.10166883
148drug transmembrane transport (GO:0006855)3.08685234
149regulation of interferon-gamma biosynthetic process (GO:0045072)3.08312893
150cyclooxygenase pathway (GO:0019371)3.06602451
151lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06388035
152cGMP-mediated signaling (GO:0019934)3.05252203
153regulation of mast cell degranulation (GO:0043304)3.01316187
154detection of molecule of bacterial origin (GO:0032490)3.01132995
155defense response to protozoan (GO:0042832)3.00638480
156neutrophil mediated immunity (GO:0002446)3.00405593
157production of molecular mediator involved in inflammatory response (GO:0002532)2.96418573
158regulation of B cell differentiation (GO:0045577)2.96269470
159regulation of mast cell activation (GO:0033003)2.92583661
160positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.91636477
161regulation of cholesterol storage (GO:0010885)2.89151640
162hydrogen peroxide biosynthetic process (GO:0050665)2.88737793
163negative regulation of mast cell activation (GO:0033004)2.88577760
164regulation of interleukin-8 biosynthetic process (GO:0045414)2.88331970
165leukocyte mediated cytotoxicity (GO:0001909)2.88243237
166positive regulation of cellular amide metabolic process (GO:0034250)2.88161935
167positive regulation of mast cell activation (GO:0033005)2.87038587
168lymphocyte mediated immunity (GO:0002449)2.86632396
169negative regulation of interleukin-17 production (GO:0032700)2.85382585
170adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.83911604
171regulation of mast cell activation involved in immune response (GO:0033006)2.83753352
172positive regulation of macrophage cytokine production (GO:0060907)2.83735000
173response to interferon-alpha (GO:0035455)2.81047638
174I-kappaB phosphorylation (GO:0007252)2.80254287
175positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.79629039
176negative regulation of phagocytosis (GO:0050765)2.79618922
177germinal center formation (GO:0002467)2.79518191
178myeloid leukocyte activation (GO:0002274)2.74492305
179lymphocyte chemotaxis (GO:0048247)2.72036704
180negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68851547
181negative regulation of cell killing (GO:0031342)2.68851547
182regulation of activation of Janus kinase activity (GO:0010533)2.68392165
183positive regulation of defense response to virus by host (GO:0002230)2.67860698
184Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65215007
185regulation of mononuclear cell migration (GO:0071675)2.64478512
186regulation of interferon-beta production (GO:0032648)2.64014277
187phagocytosis, engulfment (GO:0006911)2.61505542
188negative regulation of interleukin-12 production (GO:0032695)2.60888239
189positive regulation of tumor necrosis factor production (GO:0032760)2.60175764
190positive regulation of toll-like receptor signaling pathway (GO:0034123)2.59952680
191positive regulation of chemokine biosynthetic process (GO:0045080)2.59590609
192interferon-gamma production (GO:0032609)2.59458122
193positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59296752
194negative regulation of bone resorption (GO:0045779)2.59065503
195regulation of interleukin-12 biosynthetic process (GO:0045075)2.58378188
196negative regulation of interleukin-6 production (GO:0032715)2.58287899
197response to protozoan (GO:0001562)2.57800387
198reactive oxygen species biosynthetic process (GO:1903409)2.56263922
199angiotensin maturation (GO:0002003)11.3168684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.48328938
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.32308848
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.88106291
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.14661585
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.97867265
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73585720
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42750864
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.35920766
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.26577232
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13838349
11GATA4_25053715_ChIP-Seq_YYC3_Human3.07187920
12SOX2_27498859_Chip-Seq_STOMACH_Mouse3.06861563
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98089527
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76472206
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73589563
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70826461
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.59365416
18E2F7_22180533_ChIP-Seq_HELA_Human2.56464417
19GATA6_25053715_ChIP-Seq_YYC3_Human2.55227774
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.47307242
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.46673119
22SOX2_20726797_ChIP-Seq_SW620_Human2.37754911
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36411845
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34003025
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31209826
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.30286199
27SCL_19346495_ChIP-Seq_HPC-7_Human2.27355064
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24407821
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22800479
30* SPI1_23547873_ChIP-Seq_NB4_Human2.22500807
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16706230
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.06133325
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.01923687
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97959916
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96777116
36SPI1_23127762_ChIP-Seq_K562_Human1.93678754
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.88667280
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87935377
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87372108
40* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86993402
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79024742
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72423527
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72190327
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71016283
45VDR_21846776_ChIP-Seq_THP-1_Human1.70538642
46MYB_26560356_Chip-Seq_TH2_Human1.69946070
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68631508
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.65948616
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.63985148
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.63838418
51PU_27001747_Chip-Seq_BMDM_Mouse1.60418844
52VDR_24763502_ChIP-Seq_THP-1_Human1.60280377
53MYB_26560356_Chip-Seq_TH1_Human1.58623818
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57355466
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55322963
56MAF_26560356_Chip-Seq_TH1_Human1.55040795
57LXR_22292898_ChIP-Seq_THP-1_Human1.53819827
58* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53710113
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51443841
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49592197
61CLOCK_20551151_ChIP-Seq_293T_Human1.46745045
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.45633554
63MYC_22102868_ChIP-Seq_BL_Human1.45242393
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44980012
65RUNX_20019798_ChIP-Seq_JUKART_Human1.38755977
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37205285
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36890339
68BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.35263813
69CDX2_22108803_ChIP-Seq_LS180_Human1.34003134
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33697884
71HNF4A_19822575_ChIP-Seq_HepG2_Human1.33517027
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31390558
73TCF7_22412390_ChIP-Seq_EML_Mouse1.30447969
74VDR_24787735_ChIP-Seq_THP-1_Human1.30318800
75GATA1_22025678_ChIP-Seq_K562_Human1.28528450
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28527663
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27871945
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26891476
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.26594451
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25716022
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.25451831
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.25327911
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24333865
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23936323
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23804699
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23804699
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23804699
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23791975
89GATA2_19941826_ChIP-Seq_K562_Human1.22908541
90TFEB_21752829_ChIP-Seq_HELA_Human1.20822695
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20747687
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20150942
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19006578
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17135311
95* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16901794
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16130016
97RACK7_27058665_Chip-Seq_MCF-7_Human1.15144000
98KLF5_25053715_ChIP-Seq_YYC3_Human1.11270237
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11071903
100SA1_27219007_Chip-Seq_Bcells_Human1.10255346
101UTX_26944678_Chip-Seq_JUKART_Human1.09067370
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09004646
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08762326
104BCL6_27268052_Chip-Seq_Bcells_Human1.08523090
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08089065
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07488770
107BCOR_27268052_Chip-Seq_Bcells_Human1.06793205
108AR_21909140_ChIP-Seq_LNCAP_Human1.06579956
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06240214
110RXR_22158963_ChIP-Seq_LIVER_Mouse1.06025402
111GATA3_27048872_Chip-Seq_THYMUS_Human1.05793616
112RXR_22108803_ChIP-Seq_LS180_Human1.04033107
113* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03754460
114NANOG_20526341_ChIP-Seq_ESCs_Human1.03268024
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02957109
116EGR1_19032775_ChIP-ChIP_M12_Human1.02823401
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.02181160
118GATA3_26560356_Chip-Seq_TH2_Human1.02159474
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01587602
120P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01018558
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00041067
122GATA1_19941826_ChIP-Seq_K562_Human0.99733399
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99617668
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99492080
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99346371
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.97910190
127CEBPB_22108803_ChIP-Seq_LS180_Human0.96468852
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.96232912
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95862163
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95765510
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.94140144
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.90778084
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.90635026
134CTCF_27219007_Chip-Seq_Bcells_Human0.90396838
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88959032
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.88681254
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88604882
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88235005
139STAT1_20625510_ChIP-Seq_HELA_Human0.87552949
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.86242422
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.85991788
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84643516
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84144489
144RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83924147
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83413367
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82491802
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82165857
148MAF_26560356_Chip-Seq_TH2_Human0.81977963
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81843486
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81515620
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81347039
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80790539
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80651078
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80384211
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80181107
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.80094447
157NCOR1_26117541_ChIP-Seq_K562_Human0.79893914
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78846435
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78414804
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78196957
161IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77988181
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77898286
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76428855
164TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.75950319
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.75666187
166ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75152344
167STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74071188
168CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73512077
169HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72999310
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72960234
171* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72311011
172SPI1_20517297_ChIP-Seq_HL60_Human0.71449372
173TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69416089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.26860339
2MP0001666_abnormal_nutrient_absorption4.91571112
3MP0005085_abnormal_gallbladder_physiolo4.88196376
4MP0001835_abnormal_antigen_presentation4.56050250
5MP0004147_increased_porphyrin_level3.85220846
6MP0002139_abnormal_hepatobiliary_system3.85141712
7MP0004019_abnormal_vitamin_homeostasis3.77592477
8MP0005365_abnormal_bile_salt3.75875307
9MP0009379_abnormal_foot_pigmentation3.52697272
10MP0005058_abnormal_lysosome_morphology3.50450736
11MP0003436_decreased_susceptibility_to3.36762095
12MP0006082_CNS_inflammation3.20423674
13MP0003172_abnormal_lysosome_physiology2.91656557
14MP0001790_abnormal_immune_system2.80278132
15MP0005387_immune_system_phenotype2.80278132
16MP0002419_abnormal_innate_immunity2.77783573
17MP0005000_abnormal_immune_tolerance2.77000420
18MP0009785_altered_susceptibility_to2.67603331
19MP0002148_abnormal_hypersensitivity_rea2.67303159
20MP0001800_abnormal_humoral_immune2.66101866
21MP0000569_abnormal_digit_pigmentation2.60743265
22MP0002452_abnormal_antigen_presenting2.57384627
23MP0000685_abnormal_immune_system2.56941906
24MP0002254_reproductive_system_inflammat2.56870023
25MP0010234_abnormal_vibrissa_follicle2.52725769
26MP0005025_abnormal_response_to2.51040250
27MP0003183_abnormal_peptide_metabolism2.45769878
28MP0003303_peritoneal_inflammation2.43453519
29MP0005671_abnormal_response_to2.37147404
30MP0002723_abnormal_immune_serum2.32712615
31MP0003191_abnormal_cellular_cholesterol2.27466662
32MP0001819_abnormal_immune_cell2.11427718
33MP0002420_abnormal_adaptive_immunity2.10287861
34MP0009840_abnormal_foam_cell2.07429113
35MP0001664_abnormal_digestion2.06776939
36MP0003866_abnormal_defecation1.99359417
37MP0005409_darkened_coat_color1.99329097
38MP0005464_abnormal_platelet_physiology1.87099941
39MP0005332_abnormal_amino_acid1.83589947
40MP0009643_abnormal_urine_homeostasis1.80308202
41MP0002405_respiratory_system_inflammati1.79143671
42MP0003868_abnormal_feces_composition1.75636050
43MP0005310_abnormal_salivary_gland1.74485868
44MP0001853_heart_inflammation1.72140957
45* MP0010329_abnormal_lipoprotein_level1.68973283
46MP0005257_abnormal_intraocular_pressure1.68290433
47MP0004510_myositis1.67955461
48MP0001845_abnormal_inflammatory_respons1.67266712
49MP0003806_abnormal_nucleotide_metabolis1.66698272
50MP0003252_abnormal_bile_duct1.66324320
51MP0001533_abnormal_skeleton_physiology1.66314821
52MP0003724_increased_susceptibility_to1.64230232
53MP0000716_abnormal_immune_system1.63861971
54MP0003300_gastrointestinal_ulcer1.61344475
55MP0000538_abnormal_urinary_bladder1.59700032
56MP0004947_skin_inflammation1.58784141
57MP0000689_abnormal_spleen_morphology1.56151251
58MP0002166_altered_tumor_susceptibility1.55530141
59MP0002398_abnormal_bone_marrow1.55379411
60MP0008469_abnormal_protein_level1.54548399
61MP0001764_abnormal_homeostasis1.52296971
62MP0002396_abnormal_hematopoietic_system1.48127770
63MP0002277_abnormal_respiratory_mucosa1.46965181
64MP0003448_altered_tumor_morphology1.46774856
65MP0000477_abnormal_intestine_morphology1.45657683
66MP0010155_abnormal_intestine_physiology1.42777120
67MP0001765_abnormal_ion_homeostasis1.40322683
68MP0000343_altered_response_to1.39670881
69MP0003718_maternal_effect1.39577879
70MP0002429_abnormal_blood_cell1.37157632
71MP0003011_delayed_dark_adaptation1.36453920
72MP0009764_decreased_sensitivity_to1.36025424
73MP0005636_abnormal_mineral_homeostasis1.34773140
74MP0002722_abnormal_immune_system1.34395984
75MP0000604_amyloidosis1.31252215
76MP0010307_abnormal_tumor_latency1.29190749
77MP0005670_abnormal_white_adipose1.28426160
78MP0000678_abnormal_parathyroid_gland1.27827177
79MP0002006_tumorigenesis1.23990214
80MP0001188_hyperpigmentation1.22964535
81MP0003690_abnormal_glial_cell1.22830791
82MP0005174_abnormal_tail_pigmentation1.20178025
83MP0003075_altered_response_to1.19342190
84MP0002998_abnormal_bone_remodeling1.17658171
85MP0004858_abnormal_nervous_system1.17027772
86MP0003879_abnormal_hair_cell1.16924586
87MP0001501_abnormal_sleep_pattern1.16117689
88MP0001663_abnormal_digestive_system1.15953479
89MP0000858_altered_metastatic_potential1.15864660
90MP0002876_abnormal_thyroid_physiology1.13424269
91MP0002822_catalepsy1.12007031
92* MP0002118_abnormal_lipid_homeostasis1.10644723
93MP0009278_abnormal_bone_marrow1.08392401
94MP0005448_abnormal_energy_balance1.08307895
95MP0003705_abnormal_hypodermis_morpholog1.04335148
96MP0001545_abnormal_hematopoietic_system1.03798912
97MP0005397_hematopoietic_system_phenotyp1.03798912
98MP0000462_abnormal_digestive_system1.03219684
99MP0004270_analgesia1.02218345
100MP0009333_abnormal_splenocyte_physiolog1.00664131
101MP0005535_abnormal_body_temperature0.98840338
102MP0004264_abnormal_extraembryonic_tissu0.98239900
103MP0005075_abnormal_melanosome_morpholog0.97299004
104MP0005584_abnormal_enzyme/coenzyme_acti0.97200799
105MP0009763_increased_sensitivity_to0.95908749
106MP0005381_digestive/alimentary_phenotyp0.95770028
107MP0003566_abnormal_cell_adhesion0.95046935
108MP0000609_abnormal_liver_physiology0.91854834
109MP0000465_gastrointestinal_hemorrhage0.91818704
110MP0005076_abnormal_cell_differentiation0.89324022
111MP0004043_abnormal_pH_regulation0.88428030
112MP0010352_gastrointestinal_tract_polyps0.87726245
113MP0005166_decreased_susceptibility_to0.87663999
114MP0002138_abnormal_hepatobiliary_system0.87595887
115MP0002971_abnormal_brown_adipose0.87300305
116MP0003828_pulmonary_edema0.86963263
117MP0001873_stomach_inflammation0.86570954
118MP0004782_abnormal_surfactant_physiolog0.86335790
119MP0000490_abnormal_crypts_of0.86107693
120MP0002933_joint_inflammation0.85704155
121MP0005451_abnormal_body_composition0.85696841
122MP0005390_skeleton_phenotype0.84712517
123MP0000371_diluted_coat_color0.83751261
124MP0000015_abnormal_ear_pigmentation0.81089186
125MP0000230_abnormal_systemic_arterial0.79675450
126MP0001756_abnormal_urination0.79391460
127MP0008004_abnormal_stomach_pH0.79074825
128MP0008875_abnormal_xenobiotic_pharmacok0.78410887
129MP0002332_abnormal_exercise_endurance0.76565355
130MP0005164_abnormal_response_to0.75935077
131MP0002796_impaired_skin_barrier0.74194923
132MP0002098_abnormal_vibrissa_morphology0.72798317
133MP0003186_abnormal_redox_activity0.72531960
134MP0004808_abnormal_hematopoietic_stem0.71846808
135MP0005319_abnormal_enzyme/_coenzyme0.70948030
136MP0003656_abnormal_erythrocyte_physiolo0.70430738
137MP0003795_abnormal_bone_structure0.70285157
138MP0000703_abnormal_thymus_morphology0.70200030
139MP0001851_eye_inflammation0.69355866
140MP0000013_abnormal_adipose_tissue0.69267327
141MP0005023_abnormal_wound_healing0.68675325
142MP0005167_abnormal_blood-brain_barrier0.68546804
143MP0002136_abnormal_kidney_physiology0.68255077
144MP0003763_abnormal_thymus_physiology0.67800708
145* MP0009642_abnormal_blood_homeostasis0.67764932
146MP0000537_abnormal_urethra_morphology0.67259053
147* MP0000249_abnormal_blood_vessel0.66629590
148MP0000598_abnormal_liver_morphology0.66132378
149MP0001485_abnormal_pinna_reflex0.65870982
150MP0009115_abnormal_fat_cell0.64355530
151MP0008872_abnormal_physiological_respon0.63291230
152MP0008057_abnormal_DNA_replication0.61548276
153MP0004883_abnormal_blood_vessel0.61479531
154MP0001243_abnormal_dermal_layer0.59160099
155MP0005501_abnormal_skin_physiology0.56780255
156MP0005334_abnormal_fat_pad0.55158009
157MP0005666_abnormal_adipose_tissue0.53829567
158MP0006138_congestive_heart_failure0.51960550
159MP0002896_abnormal_bone_mineralization0.50948469
160MP0005165_increased_susceptibility_to0.50718334
161MP0008260_abnormal_autophagy0.49388407
162MP0003953_abnormal_hormone_level0.49312625
163MP0002078_abnormal_glucose_homeostasis0.48746875
164MP0001881_abnormal_mammary_gland0.48208127

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)7.29632321
2Hydroxyprolinuria (HP:0003080)7.13388429
3Abnormality of proline metabolism (HP:0010907)7.13388429
4Recurrent abscess formation (HP:0002722)6.12982416
5Hypobetalipoproteinemia (HP:0003563)6.07445512
6Recurrent bacterial skin infections (HP:0005406)5.57694852
7Chronic diarrhea (HP:0002028)5.47858418
8Abnormality of the vitamin B12 metabolism (HP:0004341)5.36144355
9Eczematoid dermatitis (HP:0000976)5.08459325
10Acanthocytosis (HP:0001927)5.03168962
11Abnormality of vitamin B metabolism (HP:0004340)5.00649896
12Ileus (HP:0002595)4.89478694
13Fat malabsorption (HP:0002630)4.88091219
14Vacuolated lymphocytes (HP:0001922)4.78608138
15Recurrent gram-negative bacterial infections (HP:0005420)4.67425449
16Systemic lupus erythematosus (HP:0002725)4.64296227
17Widely patent fontanelles and sutures (HP:0004492)4.57384329
18Confusion (HP:0001289)4.47689511
19Increased cerebral lipofuscin (HP:0011813)4.33048274
20Abnormality of glycolipid metabolism (HP:0010969)4.11645699
21Abnormality of liposaccharide metabolism (HP:0010968)4.11645699
22Abnormality of glycosphingolipid metabolism (HP:0004343)4.11645699
23Abnormality of macrophages (HP:0004311)4.02347348
24Elevated erythrocyte sedimentation rate (HP:0003565)4.01437581
25Pigmentary retinal degeneration (HP:0001146)4.01417824
26Nausea (HP:0002018)3.99945093
27Abnormality of vitamin metabolism (HP:0100508)3.96984955
28Myositis (HP:0100614)3.92264329
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.84901812
30Autoimmune thrombocytopenia (HP:0001973)3.80116218
31Hyperglycinuria (HP:0003108)3.78530682
32Glycosuria (HP:0003076)3.76705624
33Abnormality of urine glucose concentration (HP:0011016)3.76705624
34Gingivitis (HP:0000230)3.69851463
35Orchitis (HP:0100796)3.68694908
36Thin bony cortex (HP:0002753)3.66744691
37Recurrent skin infections (HP:0001581)3.59986086
38Proximal tubulopathy (HP:0000114)3.56369654
39Dysostosis multiplex (HP:0000943)3.56036337
40Wide cranial sutures (HP:0010537)3.39912669
41Hyperactive renin-angiotensin system (HP:0000841)3.36775537
42Decreased circulating renin level (HP:0003351)3.35328526
43Recurrent fungal infections (HP:0002841)3.33224116
44Axonal loss (HP:0003447)3.29028021
45Nephrolithiasis (HP:0000787)3.28581958
46Abnormality of serine family amino acid metabolism (HP:0010894)3.22818065
47Abnormality of glycine metabolism (HP:0010895)3.22818065
48Upper motor neuron abnormality (HP:0002127)3.21291301
49Alkalosis (HP:0001948)3.20580336
50Mediastinal lymphadenopathy (HP:0100721)3.19660643
51Metabolic alkalosis (HP:0200114)3.19009485
52Glomerulonephritis (HP:0000099)3.14294440
53Recurrent viral infections (HP:0004429)3.14129595
54Cellulitis (HP:0100658)3.12357942
55Periodontitis (HP:0000704)3.12350596
56Congenital sensorineural hearing impairment (HP:0008527)3.11990222
57Disinhibition (HP:0000734)3.10663025
58Prostate neoplasm (HP:0100787)3.08503984
59Abdominal distention (HP:0003270)3.04812201
60Xanthomatosis (HP:0000991)3.04387929
61Steatorrhea (HP:0002570)3.03657134
62Urinary glycosaminoglycan excretion (HP:0003541)3.00989876
63Mucopolysacchariduria (HP:0008155)3.00989876
64Hyperuricemia (HP:0002149)2.98863406
65Increased purine levels (HP:0004368)2.98863406
66Myocardial infarction (HP:0001658)2.98806012
67Posterior subcapsular cataract (HP:0007787)2.96422162
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.95404427
69Hypophosphatemia (HP:0002148)2.93143266
70Hypolipoproteinemia (HP:0010981)2.92789609
71Vasculitis (HP:0002633)2.92532626
72Optic neuritis (HP:0100653)2.92042087
73Retrobulbar optic neuritis (HP:0100654)2.92042087
74Agnosia (HP:0010524)2.91385272
75Megaloblastic anemia (HP:0001889)2.90488063
76Abnormality of polysaccharide metabolism (HP:0011012)2.89578782
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.89578782
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.89578782
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.85457448
80Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.84434822
81Colitis (HP:0002583)2.77618650
82Abnormality of small intestinal villus morphology (HP:0011472)2.76680104
83Villous atrophy (HP:0011473)2.76680104
84Potter facies (HP:0002009)2.75884910
85Facial shape deformation (HP:0011334)2.75884910
86Hyperammonemia (HP:0001987)2.75002244
87Enlarged epiphyses (HP:0010580)2.73145324
88Abnormal urine phosphate concentration (HP:0012599)2.71222598
89Chronic mucocutaneous candidiasis (HP:0002728)2.70740484
90Recurrent cutaneous fungal infections (HP:0011370)2.70740484
91Hyperparathyroidism (HP:0000843)2.70371748
92Abnormality of purine metabolism (HP:0004352)2.70250719
93Obstructive lung disease (HP:0006536)2.70159586
94Chronic obstructive pulmonary disease (HP:0006510)2.70159586
95Delayed epiphyseal ossification (HP:0002663)2.69649362
96Abnormality of renin-angiotensin system (HP:0000847)2.68632779
97Osteomyelitis (HP:0002754)2.62189750
98Basal ganglia calcification (HP:0002135)2.61901541
99Pustule (HP:0200039)2.61065152
100Meningitis (HP:0001287)2.53349834
101Hyperphosphaturia (HP:0003109)2.52720557
102Complement deficiency (HP:0004431)2.46908291
103Pulmonary infiltrates (HP:0002113)2.46900394
104Abnormality of the costochondral junction (HP:0000919)2.44796999
105Abnormal delayed hypersensitivity skin test (HP:0002963)2.43645951
106Inflammation of the large intestine (HP:0002037)2.43129031
107Loss of speech (HP:0002371)2.43120959
108Focal segmental glomerulosclerosis (HP:0000097)2.42689955
109Gingival bleeding (HP:0000225)2.42568341
110Abnormality of complement system (HP:0005339)2.41435945
111Abnormality of nucleobase metabolism (HP:0010932)2.41407364
112Pathologic fracture (HP:0002756)2.39591114
113Recurrent pneumonia (HP:0006532)2.37677470
114Hypotension (HP:0002615)2.33102040
115Agammaglobulinemia (HP:0004432)2.32491436
116Metabolic acidosis (HP:0001942)2.31418578
117Leukocytosis (HP:0001974)2.31377750
118Joint hemorrhage (HP:0005261)2.29699641
119Urticaria (HP:0001025)2.29569517
120Spontaneous hematomas (HP:0007420)2.29064708
121Cerebral palsy (HP:0100021)2.27254747
122Recurrent lower respiratory tract infections (HP:0002783)2.27022746
123Abnormality of the prostate (HP:0008775)2.24123005
124Premature loss of primary teeth (HP:0006323)2.23609643
125Hematochezia (HP:0002573)2.23421046
126Epidermoid cyst (HP:0200040)2.22941567
127Right ventricular cardiomyopathy (HP:0011663)2.22600593
128Poikilocytosis (HP:0004447)2.21606177
129Gastrointestinal inflammation (HP:0004386)2.21508944
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21072160
131Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20092646
132Thick nail (HP:0001805)2.19544332
133Interstitial pulmonary disease (HP:0006530)2.18619058
134Abnormal glucose tolerance (HP:0001952)2.16965957
135Nasal polyposis (HP:0100582)2.14743592
136Abnormality of sulfur amino acid metabolism (HP:0004339)2.14741366
137Hemorrhage of the eye (HP:0011885)2.14375896
138Subcapsular cataract (HP:0000523)2.13481385
139Amyloidosis (HP:0011034)2.12200334
140Cheilitis (HP:0100825)2.10204180
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09572685
142Gout (HP:0001997)2.09517941
143Hepatosplenomegaly (HP:0001433)2.08124355
144Dicarboxylic aciduria (HP:0003215)2.05736857
145Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05736857
146Arterial thrombosis (HP:0004420)2.05326181
147Renal tubular acidosis (HP:0001947)2.04265887
148Eosinophilia (HP:0001880)2.04023105
149Petechiae (HP:0000967)2.03213297
150Chest pain (HP:0100749)2.02487387
151Nephritis (HP:0000123)2.00896661
152Hyperphosphatemia (HP:0002905)2.00895875
153Pancreatitis (HP:0001733)2.00772049
154Abnormality of glutamine family amino acid metabolism (HP:0010902)10.6890204
155Abnormality of T cell physiology (HP:0011840)1.99947683
156Stomatitis (HP:0010280)1.98643188
157Protuberant abdomen (HP:0001538)1.97890854
158Peritonitis (HP:0002586)1.96484623
159Hypochromic microcytic anemia (HP:0004840)1.95123361
160Gastrointestinal dysmotility (HP:0002579)1.94893401
161Irritability (HP:0000737)1.94811485
162Abnormality of magnesium homeostasis (HP:0004921)1.94553058
163Hemoptysis (HP:0002105)1.94203688
164Abnormality of the nasal mucosa (HP:0000433)1.92109483
165Increased IgM level (HP:0003496)1.91988895
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.91389572
167Osteolytic defects of the hand bones (HP:0009699)1.91389572
168Growth hormone excess (HP:0000845)1.89642325
169Combined immunodeficiency (HP:0005387)1.88462543
170Renal tubular dysfunction (HP:0000124)1.87935467
171Gastrointestinal infarctions (HP:0005244)1.87553610
172Glomerulosclerosis (HP:0000096)1.86948981
173Conjugated hyperbilirubinemia (HP:0002908)1.86709399
174Panhypogammaglobulinemia (HP:0003139)1.86689044
175Recurrent bronchitis (HP:0002837)1.86615610
176Bone pain (HP:0002653)1.86224520
177Multiple lipomas (HP:0001012)1.86051598
178Anorexia (HP:0002039)1.85548312
179Peripheral demyelination (HP:0011096)1.84278084
180Poor head control (HP:0002421)1.84259098
181Metaphyseal irregularity (HP:0003025)1.81469095
182Encephalitis (HP:0002383)1.81009139
183Hypoalbuminemia (HP:0003073)1.80143171
184Abnormal albumin level (HP:0012116)1.80143171
185Restrictive lung disease (HP:0002091)1.80113750
186Abnormality of pyrimidine metabolism (HP:0004353)1.78476409
187Dehydration (HP:0001944)1.77832036
188Flat acetabular roof (HP:0003180)1.72905554
189Abnormal enzyme/coenzyme activity (HP:0012379)1.70645459
190Abnormality of alkaline phosphatase activity (HP:0004379)1.70107371
191Lethargy (HP:0001254)1.68463909
192Symptomatic seizures (HP:0011145)1.68162091
193Hyperaldosteronism (HP:0000859)1.67532926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.35128516
2ERN14.02965719
3CDK123.52554438
4KIT3.21197602
5CSF1R3.05638609
6TGFBR22.99691066
7TYK22.96479788
8BLK2.95644578
9EPHA22.95571345
10MAP3K142.74449608
11TBK12.57887964
12MAP4K12.55860128
13RIPK42.54232191
14IRAK42.43710786
15STK392.43527141
16TAOK32.42912542
17GRK62.38898769
18IRAK32.09792538
19IKBKB1.92000990
20STK101.90881331
21OXSR11.88636016
22MAP3K121.87900893
23TESK21.87736011
24IKBKE1.81227856
25JAK31.72121903
26MET1.69266961
27EPHB21.67407596
28MATK1.65727153
29JAK11.64613678
30MAP3K21.61765731
31SYK1.59911349
32GRK71.58547000
33CSK1.56482034
34PDK21.53492297
35BTK1.41164743
36HCK1.40065745
37STK241.39030029
38GRK51.38266449
39CASK1.35655309
40TNIK1.35573522
41FGFR31.32611427
42ZAP701.31721621
43CHUK1.29419740
44MAP3K131.28545007
45CAMK1D1.28298292
46ADRBK21.25197999
47LYN1.24219825
48ITK1.21360738
49AKT31.20080176
50TEC1.19493429
51DDR21.18923569
52PIK3CA1.18803127
53MYLK1.13304249
54NEK91.13035010
55PIM21.11226591
56MOS1.10066068
57MAP2K31.08529964
58GRK11.08165648
59MAP2K21.07492633
60LCK1.07472315
61MAP3K11.03744855
62EPHA41.02424552
63LMTK21.00055695
64MAP3K100.96217052
65FGFR40.94711279
66MAPK70.94399665
67EPHB10.93882782
68NME20.92860186
69JAK20.92561572
70FES0.91530102
71PIM10.91317250
72PRPF4B0.90679391
73RIPK10.89912237
74TXK0.88792292
75CAMK1G0.87311651
76TESK10.86877760
77RPS6KA40.86793439
78PDPK10.85518010
79ERBB20.83030648
80STK40.80224247
81MAP3K30.78660797
82NLK0.78307319
83PRKCD0.75703975
84PAK40.74430610
85EIF2AK20.74236629
86MAP3K110.72856504
87FLT30.71360142
88HIPK20.70730029
89PRKACG0.68939515
90PBK0.68911770
91PRKAA20.66375398
92CDC42BPA0.64717071
93FGR0.64160489
94PDK10.62292175
95SIK20.61816535
96TAOK10.61195558
97EGFR0.60974336
98TLK10.60431750
99MAP2K60.60410524
100PRKCA0.59681628
101MST40.59133910
102ABL10.57994472
103TTN0.56863796
104SCYL20.56714673
105PRKG20.56372379
106PRKCZ0.56302852
107CDK60.55414278
108MARK30.55406962
109CAMK40.54779497
110IRAK10.53814608
111CDK190.53148228
112FER0.52724478
113DYRK1B0.51310070
114IGF1R0.49489069
115PTK60.47699655
116TRPM70.44932662
117SRC0.44853483
118PIK3CG0.44138080
119MAPKAPK20.43956052
120PTK20.43408832
121MAPK120.42827104
122CLK10.42591331
123CAMK2D0.42072696
124LRRK20.41439746
125DAPK20.40081481
126MAPK110.39768807
127PRKCQ0.38285587
128EPHA30.38200576
129TRIB30.37303129
130RET0.35874096
131KSR20.34944353
132CAMKK20.34435089
133YES10.34179041
134BMPR20.33317884
135PDGFRA0.31445126
136BMX0.29383458
137CDK40.28842498
138WNK10.28194158
139MELK0.28179768
140KDR0.28130475
141CAMK2G0.27890925
142FYN0.27671541
143PRKCH0.26974213
144PRKCI0.26845031
145TTK0.26542459
146NEK60.25040927
147MAP3K80.24724348
148INSR0.24315043
149ABL20.24255847
150CAMK2B0.22170461
151ACVR1B0.20242697
152MAPK40.18185718
153BRD40.17335155

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.14748516
2Vitamin digestion and absorption_Homo sapiens_hsa049774.74091245
3Fat digestion and absorption_Homo sapiens_hsa049754.45261565
4Staphylococcus aureus infection_Homo sapiens_hsa051503.57560954
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.13173840
6Leishmaniasis_Homo sapiens_hsa051402.92445793
7Other glycan degradation_Homo sapiens_hsa005112.74628777
8Lysosome_Homo sapiens_hsa041422.73947543
9Mineral absorption_Homo sapiens_hsa049782.60171255
10Protein digestion and absorption_Homo sapiens_hsa049742.58326459
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.57314494
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.39137102
13Osteoclast differentiation_Homo sapiens_hsa043802.31399722
14Arginine biosynthesis_Homo sapiens_hsa002202.30632089
15B cell receptor signaling pathway_Homo sapiens_hsa046622.25355421
16Histidine metabolism_Homo sapiens_hsa003402.21530433
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15284022
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.13266350
19Tuberculosis_Homo sapiens_hsa051522.05690072
20Carbohydrate digestion and absorption_Homo sapiens_hsa049732.05181866
21Pertussis_Homo sapiens_hsa051332.01109066
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.00524258
23Linoleic acid metabolism_Homo sapiens_hsa005911.95724988
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94996099
25Retinol metabolism_Homo sapiens_hsa008301.94340121
26Legionellosis_Homo sapiens_hsa051341.91197364
27Caffeine metabolism_Homo sapiens_hsa002321.90576344
28Primary immunodeficiency_Homo sapiens_hsa053401.88545059
29Antigen processing and presentation_Homo sapiens_hsa046121.80650317
30Measles_Homo sapiens_hsa051621.79881891
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76161510
32Sulfur metabolism_Homo sapiens_hsa009201.69441249
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68090945
34Malaria_Homo sapiens_hsa051441.65710102
35Complement and coagulation cascades_Homo sapiens_hsa046101.64565025
36Bile secretion_Homo sapiens_hsa049761.63255559
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62985788
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61410078
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58598118
40Influenza A_Homo sapiens_hsa051641.57726967
41Allograft rejection_Homo sapiens_hsa053301.57561137
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56237051
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53372250
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.53139534
45Phagosome_Homo sapiens_hsa041451.52508581
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44891380
47Herpes simplex infection_Homo sapiens_hsa051681.44471264
48Toxoplasmosis_Homo sapiens_hsa051451.42373974
49Apoptosis_Homo sapiens_hsa042101.40751049
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39119839
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.39020999
52Graft-versus-host disease_Homo sapiens_hsa053321.35626418
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31789493
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31364185
55Rheumatoid arthritis_Homo sapiens_hsa053231.26651238
56Arginine and proline metabolism_Homo sapiens_hsa003301.26014980
57Hematopoietic cell lineage_Homo sapiens_hsa046401.22070765
58Glycerolipid metabolism_Homo sapiens_hsa005611.19690841
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19529276
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16641508
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16393560
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.13791102
63TNF signaling pathway_Homo sapiens_hsa046681.11422916
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10868366
65Fatty acid degradation_Homo sapiens_hsa000711.10628563
66Salmonella infection_Homo sapiens_hsa051321.10520500
67Chemokine signaling pathway_Homo sapiens_hsa040621.10105858
68Tryptophan metabolism_Homo sapiens_hsa003801.08548480
69African trypanosomiasis_Homo sapiens_hsa051431.03838792
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00795361
71Ether lipid metabolism_Homo sapiens_hsa005650.98659841
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96777729
73Hepatitis C_Homo sapiens_hsa051600.96297371
74Shigellosis_Homo sapiens_hsa051310.95133109
75Hepatitis B_Homo sapiens_hsa051610.93966991
76Asthma_Homo sapiens_hsa053100.92025749
77Phenylalanine metabolism_Homo sapiens_hsa003600.91368869
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.89018975
79Galactose metabolism_Homo sapiens_hsa000520.86391600
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83679694
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76134779
82Acute myeloid leukemia_Homo sapiens_hsa052210.75058686
83Pancreatic cancer_Homo sapiens_hsa052120.74624617
84Glutathione metabolism_Homo sapiens_hsa004800.73821614
85Fructose and mannose metabolism_Homo sapiens_hsa000510.73809378
86Viral myocarditis_Homo sapiens_hsa054160.72109205
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71619555
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71508628
89Pancreatic secretion_Homo sapiens_hsa049720.65638022
90Sphingolipid metabolism_Homo sapiens_hsa006000.61901168
91T cell receptor signaling pathway_Homo sapiens_hsa046600.61401781
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60996549
93ABC transporters_Homo sapiens_hsa020100.60539800
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59672476
95Chronic myeloid leukemia_Homo sapiens_hsa052200.58153187
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.57317356
97Type I diabetes mellitus_Homo sapiens_hsa049400.54096828
98Renin-angiotensin system_Homo sapiens_hsa046140.53411727
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53187335
100Arachidonic acid metabolism_Homo sapiens_hsa005900.52499145
101Autoimmune thyroid disease_Homo sapiens_hsa053200.50803888
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49634852
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49573654
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48886432
105Platelet activation_Homo sapiens_hsa046110.48465287
106Fatty acid metabolism_Homo sapiens_hsa012120.47893388
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47780302
108Peroxisome_Homo sapiens_hsa041460.46972666
109Viral carcinogenesis_Homo sapiens_hsa052030.43215271
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.43204075
111Vitamin B6 metabolism_Homo sapiens_hsa007500.42873948
112Fatty acid biosynthesis_Homo sapiens_hsa000610.41939696
113Amoebiasis_Homo sapiens_hsa051460.41227042
114Starch and sucrose metabolism_Homo sapiens_hsa005000.41117413
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40386209
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39492415
117Prion diseases_Homo sapiens_hsa050200.38368530
118Tyrosine metabolism_Homo sapiens_hsa003500.36971259
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.36698117
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.35314741
121Chemical carcinogenesis_Homo sapiens_hsa052040.35085434
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34503850
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.33838151
124Small cell lung cancer_Homo sapiens_hsa052220.33773122
125Renin secretion_Homo sapiens_hsa049240.32838806
126Prolactin signaling pathway_Homo sapiens_hsa049170.32829663
127Endocytosis_Homo sapiens_hsa041440.31646826
128p53 signaling pathway_Homo sapiens_hsa041150.30601778
129Insulin resistance_Homo sapiens_hsa049310.29877524
130Epstein-Barr virus infection_Homo sapiens_hsa051690.29116482
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.28801723
132One carbon pool by folate_Homo sapiens_hsa006700.28612893
133Notch signaling pathway_Homo sapiens_hsa043300.28312949
134Sulfur relay system_Homo sapiens_hsa041220.28154856
135PPAR signaling pathway_Homo sapiens_hsa033200.27863276
136Pentose phosphate pathway_Homo sapiens_hsa000300.27581604
137HIF-1 signaling pathway_Homo sapiens_hsa040660.24949620
138Folate biosynthesis_Homo sapiens_hsa007900.24461971
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23215134
140Thyroid hormone synthesis_Homo sapiens_hsa049180.23175599
141Biosynthesis of amino acids_Homo sapiens_hsa012300.22844375
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22828636
143Metabolic pathways_Homo sapiens_hsa011000.21933374
144Cocaine addiction_Homo sapiens_hsa050300.18969535
145Carbon metabolism_Homo sapiens_hsa012000.16749796
146Glucagon signaling pathway_Homo sapiens_hsa049220.10672608
147Serotonergic synapse_Homo sapiens_hsa047260.08251081
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08134569
149Amphetamine addiction_Homo sapiens_hsa050310.05986054
150Pyruvate metabolism_Homo sapiens_hsa006200.05835986
151Insulin secretion_Homo sapiens_hsa049110.04666907
152Tight junction_Homo sapiens_hsa045300.04369319
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.01443925
154Butanoate metabolism_Homo sapiens_hsa006500.01364918
155GnRH signaling pathway_Homo sapiens_hsa04912-0.0246114
156Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0236147
157Fatty acid elongation_Homo sapiens_hsa00062-0.0012901

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