APOBEC3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.15384987
2negative regulation of cell killing (GO:0031342)6.15384987
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.13017225
4positive regulation by symbiont of host defense response (GO:0052509)6.03021833
5modulation by symbiont of host defense response (GO:0052031)6.03021833
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.03021833
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.03021833
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.03021833
9modulation by symbiont of host immune response (GO:0052553)6.03021833
10positive regulation of gamma-delta T cell activation (GO:0046645)5.65130233
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.57736840
12antigen processing and presentation of endogenous antigen (GO:0019883)5.36745134
13neutrophil activation involved in immune response (GO:0002283)5.20638684
14detection of other organism (GO:0098543)5.13953544
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.12352319
16macrophage activation involved in immune response (GO:0002281)5.10054091
17detection of molecule of bacterial origin (GO:0032490)4.97842586
18response to peptidoglycan (GO:0032494)4.93356674
19negative regulation of interleukin-12 production (GO:0032695)4.86608740
20detection of bacterium (GO:0016045)4.80086388
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.72808802
22cellular response to type I interferon (GO:0071357)4.68168663
23type I interferon signaling pathway (GO:0060337)4.68168663
24response to type I interferon (GO:0034340)4.64833840
25detection of external biotic stimulus (GO:0098581)4.61643216
26regulation of interferon-beta biosynthetic process (GO:0045357)4.45522922
27regulation of B cell receptor signaling pathway (GO:0050855)4.44567807
28microglial cell activation (GO:0001774)4.40312185
29cellular extravasation (GO:0045123)4.40186695
30immunoglobulin mediated immune response (GO:0016064)4.27706445
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.26003532
32response to host immune response (GO:0052572)4.22999414
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.22999414
34neutrophil activation (GO:0042119)4.22481835
35production of molecular mediator involved in inflammatory response (GO:0002532)4.19516201
36leukocyte aggregation (GO:0070486)4.15275071
37detection of biotic stimulus (GO:0009595)4.12865641
38leukocyte migration involved in inflammatory response (GO:0002523)4.11527863
39regulation of gamma-delta T cell activation (GO:0046643)4.07253774
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01801737
41negative regulation of T cell mediated immunity (GO:0002710)4.00016747
42regulation of T cell tolerance induction (GO:0002664)3.97281464
43respiratory burst (GO:0045730)3.96851123
44macrophage activation (GO:0042116)3.86655415
45response to interleukin-15 (GO:0070672)3.84527000
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83587152
47response to host (GO:0075136)3.83587152
48response to host defenses (GO:0052200)3.83587152
49regulation of tolerance induction (GO:0002643)3.83441053
50granulocyte activation (GO:0036230)3.83030703
51response to interferon-alpha (GO:0035455)3.82798770
52neutrophil mediated immunity (GO:0002446)3.79384529
53antigen processing and presentation via MHC class Ib (GO:0002475)3.77065114
54interferon-gamma-mediated signaling pathway (GO:0060333)3.74744264
55myeloid cell activation involved in immune response (GO:0002275)3.67581919
56negative regulation of leukocyte mediated immunity (GO:0002704)3.65555077
57positive regulation of type 2 immune response (GO:0002830)3.65190548
58cellular response to interleukin-15 (GO:0071350)3.56835052
59positive regulation of interferon-alpha production (GO:0032727)3.54199500
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.48750208
61myeloid leukocyte mediated immunity (GO:0002444)3.46506578
62T cell migration (GO:0072678)3.44591405
63B cell mediated immunity (GO:0019724)3.43193106
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40650773
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.40293025
66regulation of mast cell degranulation (GO:0043304)3.39411546
67regulation of interferon-alpha production (GO:0032647)3.37666798
68positive regulation of tolerance induction (GO:0002645)3.35879537
69positive regulation of mast cell activation (GO:0033005)3.34022799
70positive regulation of toll-like receptor signaling pathway (GO:0034123)3.33348921
71defense response to protozoan (GO:0042832)3.32478083
72lipopolysaccharide-mediated signaling pathway (GO:0031663)3.30541356
73regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.30254920
74dendritic cell chemotaxis (GO:0002407)3.26492286
75regulation of mast cell activation (GO:0033003)3.25062179
76dendritic cell migration (GO:0036336)3.22430541
77response to interferon-beta (GO:0035456)3.20350074
78regulation of T cell mediated cytotoxicity (GO:0001914)3.20116398
79regulation of gamma-delta T cell differentiation (GO:0045586)3.19472417
80regulation of type 2 immune response (GO:0002828)3.18673557
81regulation of myeloid leukocyte mediated immunity (GO:0002886)3.17586230
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.14891468
83regulation of regulatory T cell differentiation (GO:0045589)3.14728094
84regulation of T-helper 2 cell differentiation (GO:0045628)3.14714614
85regulation of mast cell activation involved in immune response (GO:0033006)3.14487641
86regulation of antigen processing and presentation (GO:0002577)3.13916396
87negative regulation of innate immune response (GO:0045824)3.11460926
88positive regulation of antigen processing and presentation (GO:0002579)3.10429744
89positive regulation of T cell mediated cytotoxicity (GO:0001916)3.08988353
90positive regulation of interleukin-1 beta secretion (GO:0050718)3.07698963
91germinal center formation (GO:0002467)3.05363887
92leukocyte degranulation (GO:0043299)3.05050900
93negative regulation of type 2 immune response (GO:0002829)3.03214792
94lymphocyte chemotaxis (GO:0048247)3.02641017
95negative regulation of cytokine production involved in immune response (GO:0002719)3.00710128
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00023224
97response to muramyl dipeptide (GO:0032495)2.99977554
98positive regulation of interferon-beta production (GO:0032728)2.99484397
99B cell receptor signaling pathway (GO:0050853)2.96570382
100negative regulation of T-helper cell differentiation (GO:0045623)2.95727034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.19455268
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.02001143
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.94859400
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.30110863
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91678826
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74746988
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.63381159
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62758121
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.50830839
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19911256
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74641686
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70808062
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70197886
14RUNX_20019798_ChIP-Seq_JUKART_Human2.68482406
15SPI1_23547873_ChIP-Seq_NB4_Human2.68186068
16SPI1_23127762_ChIP-Seq_K562_Human2.45108964
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44016330
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42702486
19VDR_24763502_ChIP-Seq_THP-1_Human2.35072311
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.34168318
21MYB_26560356_Chip-Seq_TH2_Human2.32230790
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30482519
23MAF_26560356_Chip-Seq_TH1_Human2.14326816
24VDR_21846776_ChIP-Seq_THP-1_Human2.07212913
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04042152
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.03890857
27SCL_19346495_ChIP-Seq_HPC-7_Human2.03580983
28GATA1_22025678_ChIP-Seq_K562_Human2.02481877
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01852100
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01736627
31VDR_24787735_ChIP-Seq_THP-1_Human1.93667550
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92858757
33MYB_26560356_Chip-Seq_TH1_Human1.90926098
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88831552
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81344272
36UTX_26944678_Chip-Seq_JUKART_Human1.79935722
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79419072
38GATA3_27048872_Chip-Seq_THYMUS_Human1.75295516
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70934941
40GATA3_26560356_Chip-Seq_TH2_Human1.63974956
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62917220
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62802289
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57452902
44MAF_26560356_Chip-Seq_TH2_Human1.50866215
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44076740
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.43813901
47TCF7_22412390_ChIP-Seq_EML_Mouse1.43719910
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39420302
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38909034
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.38566597
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37707658
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35081327
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30656137
54MYC_22102868_ChIP-Seq_BL_Human1.29985627
55PU_27001747_Chip-Seq_BMDM_Mouse1.28988709
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28147748
57KDM2B_26808549_Chip-Seq_DND41_Human1.26451215
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26270793
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26062146
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25350684
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25074523
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24859507
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22886551
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21432863
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19755209
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16142519
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14574831
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10619010
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10549441
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08259995
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07900184
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05410740
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.05143930
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04846509
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04792416
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03473919
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03423501
78GATA1_19941826_ChIP-Seq_K562_Human1.03091397
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01296322
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00484560
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98302437
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95910288
83BCL6_27268052_Chip-Seq_Bcells_Human0.95876938
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92146295
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91327399
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89528295
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84898928
88* SMRT_27268052_Chip-Seq_Bcells_Human0.84835000
89BCOR_27268052_Chip-Seq_Bcells_Human0.82386244
90GATA2_19941826_ChIP-Seq_K562_Human0.82064017
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80543047
92EGR1_19032775_ChIP-ChIP_M12_Human0.80488356
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.79825232
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78075108
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.77432106
96SPI1_20517297_ChIP-Seq_HL60_Human0.75896204
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.74805172
98* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73009221
99STAT1_20625510_ChIP-Seq_HELA_Human0.70574141
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70470165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.82101339
2MP0001835_abnormal_antigen_presentation4.20042095
3MP0003436_decreased_susceptibility_to4.03516795
4MP0003303_peritoneal_inflammation3.82021880
5MP0009785_altered_susceptibility_to3.39237742
6MP0002419_abnormal_innate_immunity3.22030410
7MP0005671_abnormal_response_to3.20218196
8MP0006082_CNS_inflammation3.16171704
9MP0005025_abnormal_response_to3.09635553
10MP0001800_abnormal_humoral_immune3.06071543
11MP0000685_abnormal_immune_system3.03064077
12MP0005000_abnormal_immune_tolerance2.97660907
13MP0001790_abnormal_immune_system2.93137484
14MP0005387_immune_system_phenotype2.93137484
15MP0002723_abnormal_immune_serum2.75581950
16MP0002148_abnormal_hypersensitivity_rea2.68020100
17MP0002452_abnormal_antigen_presenting2.64345276
18MP0002420_abnormal_adaptive_immunity2.55384216
19MP0001819_abnormal_immune_cell2.54333091
20MP0001533_abnormal_skeleton_physiology2.16946869
21MP0003300_gastrointestinal_ulcer2.06122130
22MP0003191_abnormal_cellular_cholesterol1.96504949
23MP0002405_respiratory_system_inflammati1.96462398
24MP0002277_abnormal_respiratory_mucosa1.91414106
25MP0000716_abnormal_immune_system1.88362924
26MP0001845_abnormal_inflammatory_respons1.88075262
27MP0002132_abnormal_respiratory_system1.87902004
28MP0009764_decreased_sensitivity_to1.87467349
29MP0008260_abnormal_autophagy1.83096153
30MP0002398_abnormal_bone_marrow1.82694033
31MP0010155_abnormal_intestine_physiology1.80287358
32MP0003763_abnormal_thymus_physiology1.79715519
33MP0005464_abnormal_platelet_physiology1.77785756
34MP0004947_skin_inflammation1.64110671
35MP0003828_pulmonary_edema1.63817205
36MP0008469_abnormal_protein_level1.61886202
37MP0009278_abnormal_bone_marrow1.59121491
38MP0009333_abnormal_splenocyte_physiolog1.56881511
39MP0003866_abnormal_defecation1.51013775
40MP0000689_abnormal_spleen_morphology1.48231057
41MP0002722_abnormal_immune_system1.46336026
42MP0000465_gastrointestinal_hemorrhage1.45936264
43MP0002429_abnormal_blood_cell1.45702098
44MP0003172_abnormal_lysosome_physiology1.43237253
45MP0005310_abnormal_salivary_gland1.36942927
46MP0003183_abnormal_peptide_metabolism1.34198478
47MP0004883_abnormal_blood_vessel1.32605126
48MP0003075_altered_response_to1.30267797
49MP0004510_myositis1.27640696
50MP0005451_abnormal_body_composition1.25070863
51MP0000703_abnormal_thymus_morphology1.23491473
52MP0000858_altered_metastatic_potential1.21338600
53MP0005397_hematopoietic_system_phenotyp1.20804913
54MP0001545_abnormal_hematopoietic_system1.20804913
55MP0002396_abnormal_hematopoietic_system1.20118330
56MP0002166_altered_tumor_susceptibility1.18314080
57MP0004381_abnormal_hair_follicle1.17244120
58MP0005164_abnormal_response_to1.13351880
59MP0003690_abnormal_glial_cell1.11830339
60MP0003806_abnormal_nucleotide_metabolis1.11455825
61MP0001851_eye_inflammation1.10569738
62MP0002998_abnormal_bone_remodeling1.07149959
63MP0000343_altered_response_to1.03897260
64MP0000569_abnormal_digit_pigmentation1.00684591
65MP0005166_decreased_susceptibility_to0.98660104
66MP0003448_altered_tumor_morphology0.98624290
67MP0009763_increased_sensitivity_to0.93507561
68MP0001663_abnormal_digestive_system0.87288241
69MP0003045_fibrosis0.87071592
70MP0002006_tumorigenesis0.85185726
71MP0005390_skeleton_phenotype0.81691374
72MP0008004_abnormal_stomach_pH0.80692914
73MP0002332_abnormal_exercise_endurance0.79817990
74MP0009765_abnormal_xenobiotic_induced0.77188211
75MP0001853_heart_inflammation0.75554995
76MP0003221_abnormal_cardiomyocyte_apopto0.74794462
77MP0003656_abnormal_erythrocyte_physiolo0.74508772
78MP0001873_stomach_inflammation0.72774875
79MP0001986_abnormal_taste_sensitivity0.70641540
80MP0000604_amyloidosis0.67998896
81MP0002138_abnormal_hepatobiliary_system0.66821710
82MP0004808_abnormal_hematopoietic_stem0.66535058
83MP0005167_abnormal_blood-brain_barrier0.64615567
84MP0008874_decreased_physiological_sensi0.61777456
85MP0005075_abnormal_melanosome_morpholog0.60765526
86MP0000015_abnormal_ear_pigmentation0.60660114
87MP0002693_abnormal_pancreas_physiology0.58831629
88MP0000249_abnormal_blood_vessel0.58372856
89MP0003787_abnormal_imprinting0.57648422
90MP0005319_abnormal_enzyme/_coenzyme0.56469505
91MP0003795_abnormal_bone_structure0.56004149
92MP0004130_abnormal_muscle_cell0.55597753
93MP0005058_abnormal_lysosome_morphology0.55127555
94MP0000490_abnormal_crypts_of0.53778349
95MP0003878_abnormal_ear_physiology0.53244017
96MP0005377_hearing/vestibular/ear_phenot0.53244017
97MP0002933_joint_inflammation0.51797613
98MP0004484_altered_response_of0.51381215
99MP0000920_abnormal_myelination0.50433751
100MP0005376_homeostasis/metabolism_phenot0.48484533

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.64351925
2Myositis (HP:0100614)6.41557673
3Orchitis (HP:0100796)6.38879181
4Recurrent bacterial skin infections (HP:0005406)6.28995808
5Optic neuritis (HP:0100653)6.26953219
6Retrobulbar optic neuritis (HP:0100654)6.26953219
7Recurrent abscess formation (HP:0002722)6.16511258
8Abnormality of macrophages (HP:0004311)5.53908735
9Stomatitis (HP:0010280)5.38212447
10Elevated erythrocyte sedimentation rate (HP:0003565)5.19438109
11Gastrointestinal infarctions (HP:0005244)5.05084195
12Recurrent gram-negative bacterial infections (HP:0005420)4.89955694
13Recurrent fungal infections (HP:0002841)4.48115976
14Keratoconjunctivitis sicca (HP:0001097)4.47747274
15Recurrent skin infections (HP:0001581)4.29764930
16Mediastinal lymphadenopathy (HP:0100721)4.24014172
17Keratoconjunctivitis (HP:0001096)4.21245062
18Recurrent cutaneous fungal infections (HP:0011370)4.15477944
19Chronic mucocutaneous candidiasis (HP:0002728)4.15477944
20Hypochromic microcytic anemia (HP:0004840)4.14418992
21Abnormal delayed hypersensitivity skin test (HP:0002963)4.10389563
22Chronic obstructive pulmonary disease (HP:0006510)4.06781720
23Obstructive lung disease (HP:0006536)4.06781720
24Encephalitis (HP:0002383)4.04124549
25Meningitis (HP:0001287)4.00848531
26Vasculitis (HP:0002633)3.75877891
27Hemoptysis (HP:0002105)3.62033327
28Urticaria (HP:0001025)3.58800439
29Gingivitis (HP:0000230)3.57543606
30Hypochromic anemia (HP:0001931)3.52543522
31Increased IgE level (HP:0003212)3.39381080
32Episodic fever (HP:0001954)3.38834710
33Peritonitis (HP:0002586)3.38486544
34Chest pain (HP:0100749)3.37538924
35Spontaneous hematomas (HP:0007420)3.31617537
36Pulmonary infiltrates (HP:0002113)3.28702589
37Arterial thrombosis (HP:0004420)3.21344255
38T lymphocytopenia (HP:0005403)3.19456410
39Abnormality of T cell number (HP:0011839)3.18822120
40Anorexia (HP:0002039)3.18114073
41Leukocytosis (HP:0001974)3.10446811
42Prolonged bleeding time (HP:0003010)2.99641526
43Increased IgM level (HP:0003496)2.92140809
44Gingival bleeding (HP:0000225)2.91391826
45Amyloidosis (HP:0011034)2.88421189
46Recurrent viral infections (HP:0004429)2.86639824
47Gangrene (HP:0100758)2.84919859
48Pulmonary embolism (HP:0002204)2.82285876
49Cellulitis (HP:0100658)2.72558656
50Abnormality of T cells (HP:0002843)2.69073075
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69046986
52Pustule (HP:0200039)2.64998375
53Abnormality of the pleura (HP:0002103)2.64447036
54Chronic otitis media (HP:0000389)2.51924761
55Inflammation of the large intestine (HP:0002037)2.51243168
56Abnormality of the endocardium (HP:0004306)2.49728729
57Microcytic anemia (HP:0001935)2.49033629
58Epistaxis (HP:0000421)2.45714887
59Granulocytopenia (HP:0001913)2.42999059
60Panhypogammaglobulinemia (HP:0003139)2.42409589
61Abnormality of the peritoneum (HP:0002585)2.38544178
62Hypergammaglobulinemia (HP:0010702)2.37034072
63Gastrointestinal inflammation (HP:0004386)2.36699416
64Keratitis (HP:0000491)2.35923924
65Osteomyelitis (HP:0002754)2.35238792
66Cheilitis (HP:0100825)2.33865491
67Petechiae (HP:0000967)2.31278540
68Vertigo (HP:0002321)2.30832356
69Abnormality of T cell physiology (HP:0011840)2.27066198
70Sepsis (HP:0100806)2.26835681
71Eosinophilia (HP:0001880)2.24851883
72Abnormality of the pericardium (HP:0001697)2.24596974
73Glomerulopathy (HP:0100820)2.18519249
74Acne (HP:0001061)2.16125104
75Premature loss of primary teeth (HP:0006323)2.14972189
76Acute hepatic failure (HP:0006554)2.11831032
77Stomach cancer (HP:0012126)2.07939087
78Lymphopenia (HP:0001888)2.07207775
79Polyneuropathy (HP:0001271)2.05247627
80Skin ulcer (HP:0200042)2.03156206
81Recurrent bronchitis (HP:0002837)2.03074698
82Abnormality of cells of the lymphoid lineage (HP:0012140)1.98883747
83Recurrent pneumonia (HP:0006532)1.97972055
84Abnormality of iron homeostasis (HP:0011031)1.96930062
85Increased serum ferritin (HP:0003281)1.95934312
86Abnormality of eosinophils (HP:0001879)1.94112744
87Skin rash (HP:0000988)1.93354223
88Colitis (HP:0002583)1.92202451
89Autoimmune hemolytic anemia (HP:0001890)1.91839177
90Amaurosis fugax (HP:0100576)1.88434510
91Thrombophlebitis (HP:0004418)1.84602891
92Nasal polyposis (HP:0100582)1.84175110
93Loss of speech (HP:0002371)1.82611543
94Autoimmune thrombocytopenia (HP:0001973)1.81925710
95Slow saccadic eye movements (HP:0000514)1.79186524
96Abnormality of the heme biosynthetic pathway (HP:0010472)1.78073823
97Purpura (HP:0000979)1.77674438
98Viral hepatitis (HP:0006562)1.74545139
99Joint swelling (HP:0001386)1.74335419
100Arthralgia (HP:0002829)1.72633379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.80178924
2IRAK43.62645581
3TYK23.49272048
4MAP4K13.42833920
5BLK3.28091862
6CSK2.79177511
7MAP2K32.72529921
8TNK22.35731830
9JAK32.34357070
10TXK2.28352410
11IKBKE2.28241255
12FES2.27557316
13ERN12.19046601
14EPHB12.13324182
15GRK62.07094370
16ZAP702.02098021
17FGR2.00492292
18BTK1.74837695
19JAK11.74767653
20HCK1.73070870
21MAP3K141.71092531
22SYK1.68214182
23TAOK11.65867053
24TAOK31.61995544
25JAK21.58832617
26MAP3K31.58795749
27KIT1.58271511
28TBK11.53868345
29MAP3K111.51434856
30LYN1.46269548
31PRPF4B1.41296551
32MATK1.40069351
33IRAK11.38170264
34MAP3K131.27251622
35FGFR41.20594535
36LCK1.18923706
37MAP3K11.17406348
38YES11.15056658
39SIK31.13996746
40KSR21.12814975
41BMPR21.07138608
42ITK1.05276252
43IKBKB1.04421940
44MARK31.04070608
45GRK71.03703246
46CSF1R1.01590251
47FGFR30.99404823
48IRAK20.98884387
49DAPK20.97112897
50TEC0.89928332
51MARK20.83901356
52PRKD20.81535113
53SIK20.78125412
54PTK2B0.77460993
55PTK60.77411986
56PDK10.77351575
57EPHA30.75239207
58ACVR1B0.73238740
59MAP3K60.71513707
60CDK190.70639869
61STK100.65955013
62MAP3K70.64534508
63TAOK20.64411980
64PDPK10.62888498
65PIK3CG0.61706203
66FYN0.61102536
67STK110.59203859
68MAP2K40.58427334
69MAP2K60.57793829
70CDC42BPA0.57167197
71MAP3K20.56439695
72MAP3K50.55593467
73LRRK20.55210585
74NLK0.54833376
75PRKCQ0.52749669
76DYRK1B0.50933155
77HIPK20.50910813
78IRAK30.49645801
79PIM10.46433529
80TESK20.45833850
81MAPK120.44603572
82KSR10.44521850
83TGFBR20.44179716
84SGK30.43141030
85MAPK70.43128092
86CAMKK20.39489847
87ADRBK20.39388493
88STK380.38438039
89SGK20.38313268
90RAF10.38031394
91CAMKK10.37555339
92PRKCZ0.35445734
93DYRK30.34952299
94WNK10.33930419
95RPS6KA60.33713396
96RPS6KC10.30767089
97RPS6KL10.30767089
98PRKCD0.29878196
99MAPKAPK20.28027245
100RET0.27386722

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.17429031
2Osteoclast differentiation_Homo sapiens_hsa043803.08295983
3Staphylococcus aureus infection_Homo sapiens_hsa051503.02418503
4Graft-versus-host disease_Homo sapiens_hsa053322.63184940
5Allograft rejection_Homo sapiens_hsa053302.62330952
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.51323490
7Autoimmune thyroid disease_Homo sapiens_hsa053202.42927908
8Tuberculosis_Homo sapiens_hsa051522.30707282
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.27329470
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.24417115
11Measles_Homo sapiens_hsa051622.15691644
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11133266
13B cell receptor signaling pathway_Homo sapiens_hsa046622.01084330
14Type I diabetes mellitus_Homo sapiens_hsa049402.00767203
15Malaria_Homo sapiens_hsa051441.98200946
16Primary immunodeficiency_Homo sapiens_hsa053401.96550552
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90837483
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90767375
19Influenza A_Homo sapiens_hsa051641.87430256
20Chemokine signaling pathway_Homo sapiens_hsa040621.85658389
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.81079190
22African trypanosomiasis_Homo sapiens_hsa051431.72622192
23Antigen processing and presentation_Homo sapiens_hsa046121.69805568
24Legionellosis_Homo sapiens_hsa051341.69099242
25Hematopoietic cell lineage_Homo sapiens_hsa046401.61182216
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.59133288
27Toxoplasmosis_Homo sapiens_hsa051451.57744434
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57204704
29Herpes simplex infection_Homo sapiens_hsa051681.56509059
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52228324
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.49783350
32T cell receptor signaling pathway_Homo sapiens_hsa046601.46720918
33Viral myocarditis_Homo sapiens_hsa054161.45413624
34Phagosome_Homo sapiens_hsa041451.44971903
35TNF signaling pathway_Homo sapiens_hsa046681.39466967
36Acute myeloid leukemia_Homo sapiens_hsa052211.38360083
37Asthma_Homo sapiens_hsa053101.37763002
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36462813
39Hepatitis C_Homo sapiens_hsa051601.32072779
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23376520
41Rheumatoid arthritis_Homo sapiens_hsa053231.21235304
42Hepatitis B_Homo sapiens_hsa051611.17936219
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17908508
44Pertussis_Homo sapiens_hsa051331.17284307
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01197787
46Platelet activation_Homo sapiens_hsa046110.97639205
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.93766651
48Salmonella infection_Homo sapiens_hsa051320.92759867
49Non-small cell lung cancer_Homo sapiens_hsa052230.88529308
50Apoptosis_Homo sapiens_hsa042100.88299431
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86601195
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85922080
53Shigellosis_Homo sapiens_hsa051310.85906795
54Prolactin signaling pathway_Homo sapiens_hsa049170.84638291
55VEGF signaling pathway_Homo sapiens_hsa043700.78250682
56Pancreatic cancer_Homo sapiens_hsa052120.77036536
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74947299
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74066157
59Dorso-ventral axis formation_Homo sapiens_hsa043200.68716126
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68212345
61Endocytosis_Homo sapiens_hsa041440.62733454
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.62308929
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.62271183
64Lysosome_Homo sapiens_hsa041420.61266553
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60945855
66Epstein-Barr virus infection_Homo sapiens_hsa051690.60534874
67Renal cell carcinoma_Homo sapiens_hsa052110.60370062
68FoxO signaling pathway_Homo sapiens_hsa040680.60209191
69Regulation of autophagy_Homo sapiens_hsa041400.59973984
70Other glycan degradation_Homo sapiens_hsa005110.58753808
71Chronic myeloid leukemia_Homo sapiens_hsa052200.58169964
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.57795037
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55884136
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.53435437
75Notch signaling pathway_Homo sapiens_hsa043300.52921190
76Viral carcinogenesis_Homo sapiens_hsa052030.50382914
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49463242
78Amoebiasis_Homo sapiens_hsa051460.47109946
79GnRH signaling pathway_Homo sapiens_hsa049120.44169983
80Type II diabetes mellitus_Homo sapiens_hsa049300.42904308
81Choline metabolism in cancer_Homo sapiens_hsa052310.41533987
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39970546
83HIF-1 signaling pathway_Homo sapiens_hsa040660.39713199
84MAPK signaling pathway_Homo sapiens_hsa040100.39419400
85HTLV-I infection_Homo sapiens_hsa051660.37640425
86Endometrial cancer_Homo sapiens_hsa052130.37419502
87Collecting duct acid secretion_Homo sapiens_hsa049660.36326685
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35547411
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34689365
90Insulin resistance_Homo sapiens_hsa049310.34635785
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.34522659
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33366563
93Rap1 signaling pathway_Homo sapiens_hsa040150.32595604
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31946648
95Colorectal cancer_Homo sapiens_hsa052100.24608789
96Inositol phosphate metabolism_Homo sapiens_hsa005620.24488703
97mTOR signaling pathway_Homo sapiens_hsa041500.24483962
98ErbB signaling pathway_Homo sapiens_hsa040120.22251814
99Arachidonic acid metabolism_Homo sapiens_hsa005900.21655353
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.21646698

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