APOBEC3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.58572905
2cytidine metabolic process (GO:0046087)6.58572905
3cytidine catabolic process (GO:0006216)6.58572905
4* DNA deamination (GO:0045006)6.24410840
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.83111905
6* regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.62432153
7positive regulation of defense response to virus by host (GO:0002230)4.47154897
8regulation of regulatory T cell differentiation (GO:0045589)4.28473018
9cellular response to interleukin-15 (GO:0071350)4.14453200
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.12613089
11negative T cell selection (GO:0043383)3.93652619
12negative thymic T cell selection (GO:0045060)3.69519177
13behavioral response to nicotine (GO:0035095)3.67517873
14positive regulation of gamma-delta T cell activation (GO:0046645)3.66851465
15regulation of B cell receptor signaling pathway (GO:0050855)3.66551379
16response to interleukin-15 (GO:0070672)3.54271532
17response to interferon-beta (GO:0035456)3.44364583
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40380948
19negative regulation of cell killing (GO:0031342)3.40380948
20tolerance induction (GO:0002507)3.31904588
21activated T cell proliferation (GO:0050798)3.27145662
22cellular response to interferon-beta (GO:0035458)3.25535432
23regulation of alpha-beta T cell proliferation (GO:0046640)3.21970155
24positive thymic T cell selection (GO:0045059)3.18933153
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15827402
26regulation of defense response to virus by host (GO:0050691)3.14006761
27positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11753325
28water-soluble vitamin biosynthetic process (GO:0042364)3.08859403
29L-fucose catabolic process (GO:0042355)3.08812250
30fucose catabolic process (GO:0019317)3.08812250
31L-fucose metabolic process (GO:0042354)3.08812250
32positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06587247
33positive T cell selection (GO:0043368)3.04705154
34negative regulation of telomere maintenance (GO:0032205)3.03654748
35antigen processing and presentation of endogenous antigen (GO:0019883)3.03423956
36positive regulation of calcium-mediated signaling (GO:0050850)3.03248874
37regulation of T cell mediated cytotoxicity (GO:0001914)2.99651323
38pyrimidine nucleoside catabolic process (GO:0046135)2.99525020
39regulation of gamma-delta T cell differentiation (GO:0045586)2.97319485
40negative regulation of mast cell activation (GO:0033004)2.95181741
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93931764
42T cell migration (GO:0072678)2.93244614
43mitochondrial respiratory chain complex I assembly (GO:0032981)2.92572675
44NADH dehydrogenase complex assembly (GO:0010257)2.92572675
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92572675
46protein complex biogenesis (GO:0070271)2.91658913
47platelet dense granule organization (GO:0060155)2.89441282
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87692448
49mast cell activation (GO:0045576)2.87453888
50regulation of gamma-delta T cell activation (GO:0046643)2.86732590
51DNA demethylation (GO:0080111)2.85766030
52regulation of T cell receptor signaling pathway (GO:0050856)2.83930428
53adaptation of signaling pathway (GO:0023058)2.82587339
54interferon-gamma production (GO:0032609)2.82019143
55positive regulation of fatty acid transport (GO:2000193)2.81964837
56positive regulation of prostaglandin secretion (GO:0032308)2.79822741
57regulation of B cell differentiation (GO:0045577)2.79798941
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78224580
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.78208100
60regulation of leukocyte mediated cytotoxicity (GO:0001910)2.78056865
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76597544
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76597544
63endoderm formation (GO:0001706)2.75752358
64mitochondrial respiratory chain complex assembly (GO:0033108)2.71110967
65mast cell degranulation (GO:0043303)2.68851387
66mast cell activation involved in immune response (GO:0002279)2.68851387
67regulation of isotype switching to IgG isotypes (GO:0048302)2.68670882
68positive regulation of B cell differentiation (GO:0045579)2.65942179
69positive regulation of T cell differentiation in thymus (GO:0033089)2.64855882
70regulation of germinal center formation (GO:0002634)2.64401924
71regulation of mesoderm development (GO:2000380)2.64232533
72negative regulation of T cell mediated immunity (GO:0002710)2.63983192
73regulation of cell killing (GO:0031341)2.63424597
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63023166
75regulation of natural killer cell mediated immunity (GO:0002715)2.63023166
76thymic T cell selection (GO:0045061)2.60450744
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.59396638
78positive regulation of cell killing (GO:0031343)2.59057808
79T cell selection (GO:0045058)2.57376006
80immunoglobulin mediated immune response (GO:0016064)2.57039556
81positive regulation of icosanoid secretion (GO:0032305)2.56299431
82preassembly of GPI anchor in ER membrane (GO:0016254)2.53894654
83antigen receptor-mediated signaling pathway (GO:0050851)2.50009969
84cellular response to exogenous dsRNA (GO:0071360)2.49063518
85* negative regulation of viral genome replication (GO:0045071)2.48816271
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47716846
87negative regulation by host of viral transcription (GO:0043922)2.44036564
88indolalkylamine metabolic process (GO:0006586)2.43409560
89interferon-gamma secretion (GO:0072643)2.43060057
90positive regulation of T-helper 1 type immune response (GO:0002827)2.41557312
91negative regulation of B cell proliferation (GO:0030889)2.41003290
92T cell receptor signaling pathway (GO:0050852)2.40985336
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40729112
94negative regulation of T cell apoptotic process (GO:0070233)2.40022014
95DNA dealkylation (GO:0035510)2.37372272
96rRNA catabolic process (GO:0016075)2.36868328
97regulation of T-helper 1 type immune response (GO:0002825)2.35381844
98indole-containing compound catabolic process (GO:0042436)2.34995501
99indolalkylamine catabolic process (GO:0046218)2.34995501
100tryptophan catabolic process (GO:0006569)2.34995501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.72871101
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56648253
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23470979
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15935680
5ZNF274_21170338_ChIP-Seq_K562_Hela3.01002422
6VDR_22108803_ChIP-Seq_LS180_Human2.84460653
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.70317977
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.49336901
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.41944723
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.37120133
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.33453394
12EZH2_22144423_ChIP-Seq_EOC_Human2.26281000
13RUNX_20019798_ChIP-Seq_JUKART_Human2.25713196
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23101266
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20212670
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.12864413
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12115317
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.95067667
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.94870575
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91723739
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89527740
22IRF1_19129219_ChIP-ChIP_H3396_Human1.87677415
23GATA3_26560356_Chip-Seq_TH2_Human1.86873178
24MYB_26560356_Chip-Seq_TH2_Human1.85956026
25VDR_23849224_ChIP-Seq_CD4+_Human1.79838381
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77697405
27* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72599711
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70128866
29GATA3_27048872_Chip-Seq_THYMUS_Human1.62792082
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57579010
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57570643
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49134436
33MYC_18940864_ChIP-ChIP_HL60_Human1.48482045
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44337187
35TP53_22573176_ChIP-Seq_HFKS_Human1.43374413
36FOXP3_21729870_ChIP-Seq_TREG_Human1.41949516
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.41467461
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40778250
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36219450
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.35243695
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35243695
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29041256
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27748265
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27175808
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26094464
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25827353
47NANOG_20526341_ChIP-Seq_ESCs_Human1.25405367
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.24572821
49MYB_26560356_Chip-Seq_TH1_Human1.24008265
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23142667
51ER_23166858_ChIP-Seq_MCF-7_Human1.22022307
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21801881
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20954839
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20610724
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19441323
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19264564
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18106258
58IGF1R_20145208_ChIP-Seq_DFB_Human1.17233930
59TAF2_19829295_ChIP-Seq_ESCs_Human1.16890004
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16311271
61EWS_26573619_Chip-Seq_HEK293_Human1.15806246
62AR_20517297_ChIP-Seq_VCAP_Human1.14136774
63NCOR_22424771_ChIP-Seq_293T_Human1.13065626
64CIITA_25753668_ChIP-Seq_RAJI_Human1.12891475
65* SOX2_19829295_ChIP-Seq_ESCs_Human1.11185238
66* NANOG_19829295_ChIP-Seq_ESCs_Human1.11185238
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.10607013
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09614759
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.09055514
70RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08357483
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08241217
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07839287
73BCAT_22108803_ChIP-Seq_LS180_Human1.07623311
74SMRT_27268052_Chip-Seq_Bcells_Human1.06961520
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.06431830
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06276418
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06223964
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05343263
79GATA3_26560356_Chip-Seq_TH1_Human1.05238420
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04984408
81ERA_21632823_ChIP-Seq_H3396_Human1.04846420
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04259285
83BCL6_27268052_Chip-Seq_Bcells_Human1.04086165
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03472071
85HOXB7_26014856_ChIP-Seq_BT474_Human1.03437007
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03384847
87P300_27268052_Chip-Seq_Bcells_Human1.03238987
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02873217
89GBX2_23144817_ChIP-Seq_PC3_Human1.02557168
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01718637
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00639980
92* FOXH1_21741376_ChIP-Seq_EPCs_Human1.00576426
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99714262
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99667948
95P300_19829295_ChIP-Seq_ESCs_Human0.99002873
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98380999
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98067861
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.97619123
99SPI1_23547873_ChIP-Seq_NB4_Human0.95848581
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95729847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.33073729
2MP0001835_abnormal_antigen_presentation2.81310654
3MP0000685_abnormal_immune_system2.79151300
4MP0001800_abnormal_humoral_immune2.70447347
5MP0008877_abnormal_DNA_methylation2.68983086
6MP0002138_abnormal_hepatobiliary_system2.65569933
7MP0003724_increased_susceptibility_to2.52525056
8MP0003763_abnormal_thymus_physiology2.41275252
9MP0001790_abnormal_immune_system2.39418113
10MP0005387_immune_system_phenotype2.39418113
11MP0005000_abnormal_immune_tolerance2.23048388
12MP0001873_stomach_inflammation2.20084953
13MP0002723_abnormal_immune_serum2.14852166
14MP0009785_altered_susceptibility_to2.06061790
15MP0002148_abnormal_hypersensitivity_rea2.04358283
16MP0002420_abnormal_adaptive_immunity2.02360056
17MP0006292_abnormal_olfactory_placode2.00604879
18MP0001819_abnormal_immune_cell1.99464495
19MP0002102_abnormal_ear_morphology1.96174642
20MP0002452_abnormal_antigen_presenting1.93560335
21MP0009333_abnormal_splenocyte_physiolog1.80826222
22MP0002876_abnormal_thyroid_physiology1.77729148
23MP0005645_abnormal_hypothalamus_physiol1.77279671
24MP0003787_abnormal_imprinting1.77139854
25MP0003195_calcinosis1.76585443
26MP0008872_abnormal_physiological_respon1.75490401
27MP0002277_abnormal_respiratory_mucosa1.75212935
28MP0005025_abnormal_response_to1.70275856
29MP0003436_decreased_susceptibility_to1.69788429
30MP0003646_muscle_fatigue1.67107469
31MP0005646_abnormal_pituitary_gland1.60001114
32MP0002398_abnormal_bone_marrow1.57184736
33MP0000716_abnormal_immune_system1.55991019
34MP0000689_abnormal_spleen_morphology1.53287518
35MP0002163_abnormal_gland_morphology1.53261250
36MP0003866_abnormal_defecation1.51800712
37MP0001986_abnormal_taste_sensitivity1.49229048
38MP0001968_abnormal_touch/_nociception1.47442286
39MP0005075_abnormal_melanosome_morpholog1.46356656
40MP0002405_respiratory_system_inflammati1.34921886
41MP0004142_abnormal_muscle_tone1.33782273
42MP0005551_abnormal_eye_electrophysiolog1.33130853
43MP0006082_CNS_inflammation1.32743218
44MP0002837_dystrophic_cardiac_calcinosis1.30799878
45MP0005389_reproductive_system_phenotype1.28481765
46MP0002419_abnormal_innate_immunity1.27090158
47MP0000372_irregular_coat_pigmentation1.25742806
48MP0001845_abnormal_inflammatory_respons1.25642903
49MP0001919_abnormal_reproductive_system1.25526406
50MP0000703_abnormal_thymus_morphology1.24508889
51MP0002722_abnormal_immune_system1.24159785
52MP0003011_delayed_dark_adaptation1.24094444
53MP0004145_abnormal_muscle_electrophysio1.24090809
54MP0006072_abnormal_retinal_apoptosis1.22176795
55MP0005084_abnormal_gallbladder_morpholo1.19855470
56MP0008875_abnormal_xenobiotic_pharmacok1.18954058
57MP0003283_abnormal_digestive_organ1.18881411
58MP0002429_abnormal_blood_cell1.18615207
59MP0004885_abnormal_endolymph1.17821430
60MP0001485_abnormal_pinna_reflex1.15110970
61MP0005310_abnormal_salivary_gland1.14588463
62MP0005174_abnormal_tail_pigmentation1.11038338
63MP0010155_abnormal_intestine_physiology1.10600461
64MP0005379_endocrine/exocrine_gland_phen1.10568942
65MP0003786_premature_aging1.10062195
66MP0009764_decreased_sensitivity_to1.07484907
67MP0002166_altered_tumor_susceptibility0.97978764
68MP0002736_abnormal_nociception_after0.97315270
69MP0004147_increased_porphyrin_level0.96246466
70MP0002693_abnormal_pancreas_physiology0.96118163
71MP0000465_gastrointestinal_hemorrhage0.94158844
72MP0008995_early_reproductive_senescence0.94135093
73MP0001663_abnormal_digestive_system0.88944722
74MP0000631_abnormal_neuroendocrine_gland0.88634712
75MP0009745_abnormal_behavioral_response0.87910272
76MP0008469_abnormal_protein_level0.86733069
77MP0002160_abnormal_reproductive_system0.86411652
78MP0002933_joint_inflammation0.86300145
79MP0002638_abnormal_pupillary_reflex0.85495760
80MP0009765_abnormal_xenobiotic_induced0.85045764
81MP0001905_abnormal_dopamine_level0.84787276
82MP0002653_abnormal_ependyma_morphology0.82385266
83MP0005253_abnormal_eye_physiology0.81632260
84MP0003806_abnormal_nucleotide_metabolis0.81430730
85MP0001533_abnormal_skeleton_physiology0.80021273
86MP0008058_abnormal_DNA_repair0.76648953
87MP0002095_abnormal_skin_pigmentation0.76115577
88MP0002006_tumorigenesis0.75965882
89MP0002928_abnormal_bile_duct0.75582100
90MP0001501_abnormal_sleep_pattern0.71892210
91MP0005464_abnormal_platelet_physiology0.71433306
92MP0001765_abnormal_ion_homeostasis0.70547542
93MP0002272_abnormal_nervous_system0.68603211
94MP0000569_abnormal_digit_pigmentation0.67947338
95MP0003252_abnormal_bile_duct0.67401875
96MP0006036_abnormal_mitochondrial_physio0.67240782
97MP0000613_abnormal_salivary_gland0.66041539
98MP0004133_heterotaxia0.64750371
99MP0000230_abnormal_systemic_arterial0.62780287
100MP0000015_abnormal_ear_pigmentation0.61318759

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)3.89085276
2Abnormal delayed hypersensitivity skin test (HP:0002963)3.53004145
3Pancreatic cysts (HP:0001737)3.41839479
4Stomatitis (HP:0010280)3.36585576
5Elevated erythrocyte sedimentation rate (HP:0003565)3.36135785
6Congenital stationary night blindness (HP:0007642)3.33394270
7Abnormality of T cell number (HP:0011839)3.24627138
8Abnormality of T cells (HP:0002843)3.06999563
9Severe combined immunodeficiency (HP:0004430)3.04136922
10T lymphocytopenia (HP:0005403)2.93130854
11Pancreatic fibrosis (HP:0100732)2.91406948
12Autoimmune hemolytic anemia (HP:0001890)2.85941190
13Abnormality of T cell physiology (HP:0011840)2.84755066
14Abnormality of midbrain morphology (HP:0002418)2.83536536
15Molar tooth sign on MRI (HP:0002419)2.83536536
16Panhypogammaglobulinemia (HP:0003139)2.82556850
17Agammaglobulinemia (HP:0004432)2.70225742
18True hermaphroditism (HP:0010459)2.67381757
19Increased IgM level (HP:0003496)2.66612643
20Stomach cancer (HP:0012126)2.58167352
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57027834
22Abnormal rod and cone electroretinograms (HP:0008323)2.55148218
23Abnormality of eosinophils (HP:0001879)2.54624039
24Abolished electroretinogram (ERG) (HP:0000550)2.53828003
25Chronic mucocutaneous candidiasis (HP:0002728)2.50771077
26Recurrent cutaneous fungal infections (HP:0011370)2.50771077
27Thyroiditis (HP:0100646)2.49027744
28Abnormality of the renal cortex (HP:0011035)2.48087010
29Asplenia (HP:0001746)2.45324459
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.45281889
313-Methylglutaconic aciduria (HP:0003535)2.44018155
32Mitochondrial inheritance (HP:0001427)2.43450396
33Recurrent fungal infections (HP:0002841)2.41845188
34Encephalitis (HP:0002383)2.41724798
35Pendular nystagmus (HP:0012043)2.40990420
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40750329
37Abnormality of the prostate (HP:0008775)2.40460900
38Optic neuritis (HP:0100653)2.39052943
39Retrobulbar optic neuritis (HP:0100654)2.39052943
40Abnormality of B cell number (HP:0010975)2.38544078
41Acute necrotizing encephalopathy (HP:0006965)2.38223811
42Attenuation of retinal blood vessels (HP:0007843)2.37372730
43Nephronophthisis (HP:0000090)2.32995521
44Myositis (HP:0100614)2.32895104
45Methylmalonic acidemia (HP:0002912)2.26941866
46Methylmalonic aciduria (HP:0012120)2.24305288
47Pustule (HP:0200039)2.22705623
48Meningitis (HP:0001287)2.22704655
49Eosinophilia (HP:0001880)2.17961058
50Increased CSF lactate (HP:0002490)2.17226818
51Vasculitis (HP:0002633)2.17152554
52Combined immunodeficiency (HP:0005387)2.14702323
53Recurrent bronchitis (HP:0002837)2.14461539
54Renal cortical cysts (HP:0000803)2.11742470
55Clumsiness (HP:0002312)2.10173033
56Leukocytosis (HP:0001974)2.09600417
57Progressive macrocephaly (HP:0004481)2.09298835
58Autoimmune thrombocytopenia (HP:0001973)2.07965670
59Abnormal mitochondria in muscle tissue (HP:0008316)2.07241265
60Congenital, generalized hypertrichosis (HP:0004540)2.06078744
61Abnormal drinking behavior (HP:0030082)2.05388269
62Polydipsia (HP:0001959)2.05388269
63Orchitis (HP:0100796)2.03950124
64Pulmonary infiltrates (HP:0002113)2.03535252
65Abnormality of the renal medulla (HP:0100957)2.01955102
66Type II lissencephaly (HP:0007260)1.98752923
67B lymphocytopenia (HP:0010976)1.97902582
68Acute encephalopathy (HP:0006846)1.97555800
69IgM deficiency (HP:0002850)1.96199472
70Neutropenia (HP:0001875)1.95746049
71Lymphopenia (HP:0001888)1.93600997
72Prostate neoplasm (HP:0100787)1.93237761
73Aplasia/hypoplasia of the uterus (HP:0008684)1.91291946
74Abnormality of cells of the lymphoid lineage (HP:0012140)1.89390627
75Hepatocellular necrosis (HP:0001404)1.86711414
76Optic disc pallor (HP:0000543)1.86245429
77Alveolar cell carcinoma (HP:0006519)1.84797196
78Mediastinal lymphadenopathy (HP:0100721)1.84145366
79Decreased central vision (HP:0007663)1.83283841
80Aplastic anemia (HP:0001915)1.83077321
81Granulocytopenia (HP:0001913)1.82344299
82Lipid accumulation in hepatocytes (HP:0006561)1.79621153
83Recurrent sinusitis (HP:0011108)1.79559552
84Cystic liver disease (HP:0006706)1.79556829
85Absent thumb (HP:0009777)1.78882137
86Decreased circulating renin level (HP:0003351)1.78787325
87Hypoplasia of the uterus (HP:0000013)1.78153633
88Abnormal biliary tract physiology (HP:0012439)1.76936613
89Bile duct proliferation (HP:0001408)1.76936613
90Sclerocornea (HP:0000647)1.76781462
91Chronic diarrhea (HP:0002028)1.75515289
92Abnormality of the renal collecting system (HP:0004742)1.74231945
93Abnormality of DNA repair (HP:0003254)1.74226311
94Keratoconjunctivitis (HP:0001096)1.73610356
95Hypochromic anemia (HP:0001931)1.73115734
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72648724
97Progressive inability to walk (HP:0002505)1.71905448
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70924660
99Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70924660
100Polyuria (HP:0000103)1.70685715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.68209311
2TXK4.63397228
3TAOK33.42917038
4FRK3.33272794
5MAP4K13.14468133
6ADRBK22.87330094
7NUAK12.49815756
8GRK12.39884042
9ZAK2.24288544
10BMPR1B2.00182251
11KIT1.81737283
12ITK1.80888205
13FES1.74124895
14TEC1.71990731
15SYK1.70787888
16ACVR1B1.68681426
17WNK41.63656651
18GRK61.62288896
19MAP4K21.58167419
20IKBKB1.53836875
21VRK21.51683882
22IKBKE1.50148023
23KDR1.45599623
24MST41.39810007
25PRKCQ1.37148276
26BTK1.33166143
27PINK11.32208630
28BCKDK1.28308295
29WNK31.25624316
30LCK1.22037037
31RIPK41.21621830
32MAPK131.20890467
33OXSR11.20855124
34LYN1.15526677
35VRK11.13485694
36PIK3CA1.11695951
37TNK21.10449754
38CSK1.03895100
39MAPKAPK30.98003090
40ADRBK10.96196902
41MAP2K60.95974735
42GRK70.94276891
43CAMKK20.94151977
44IRAK40.92852236
45JAK30.89645029
46INSRR0.88108842
47DAPK20.87713979
48STK160.83112006
49DYRK20.79892838
50CSF1R0.78239742
51TBK10.76867074
52BLK0.72482684
53TIE10.70441398
54TAF10.69461862
55HCK0.67979214
56MAP2K20.67679176
57GRK50.67219017
58STK390.65896334
59ZAP700.65480751
60PIM10.63505363
61TESK20.62269093
62BUB10.61521885
63TYK20.60499692
64EIF2AK30.60455676
65RPS6KA50.59123234
66MAP3K140.56027480
67PLK20.54528880
68STK100.51557396
69PRKCI0.49033107
70SIK20.48575309
71TGFBR10.47926000
72MARK30.47496194
73STK110.46443866
74TRIM280.44259541
75IGF1R0.43826719
76JAK10.42575887
77PLK40.41032371
78CHUK0.39633764
79PHKG10.39013799
80PHKG20.39013799
81TNIK0.38906639
82MAPKAPK50.38794106
83EIF2AK20.36995655
84PRKCG0.36765656
85PASK0.36715739
86BMPR20.36280811
87PRKACA0.36150179
88MATK0.35499626
89ATR0.34596704
90PTK2B0.34440820
91DAPK10.34358408
92PAK30.34024819
93HIPK20.33862474
94ABL10.33689012
95MAP3K110.32216708
96CSNK1A10.31811459
97PRKCA0.31792036
98RPS6KA60.30379168
99PRKCD0.29154832
100PRKCE0.28211274

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.53084902
2Graft-versus-host disease_Homo sapiens_hsa053323.23546024
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.17930726
4Autoimmune thyroid disease_Homo sapiens_hsa053203.12773222
5Allograft rejection_Homo sapiens_hsa053303.11134534
6Type I diabetes mellitus_Homo sapiens_hsa049402.51942257
7Asthma_Homo sapiens_hsa053102.41886102
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20211588
9Oxidative phosphorylation_Homo sapiens_hsa001902.06122503
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.06095026
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97565318
12Antigen processing and presentation_Homo sapiens_hsa046121.97508503
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93361329
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92968972
15Linoleic acid metabolism_Homo sapiens_hsa005911.92804025
16Phototransduction_Homo sapiens_hsa047441.82685977
17Hematopoietic cell lineage_Homo sapiens_hsa046401.71442117
18Homologous recombination_Homo sapiens_hsa034401.69545968
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68126693
20Parkinsons disease_Homo sapiens_hsa050121.64910322
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64565974
22Caffeine metabolism_Homo sapiens_hsa002321.61512557
23Proteasome_Homo sapiens_hsa030501.61121114
24RNA polymerase_Homo sapiens_hsa030201.55974274
25Nitrogen metabolism_Homo sapiens_hsa009101.43720733
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.42900256
27T cell receptor signaling pathway_Homo sapiens_hsa046601.40911906
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40199654
29Ribosome_Homo sapiens_hsa030101.37089330
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33891190
31Rheumatoid arthritis_Homo sapiens_hsa053231.29445310
32Protein export_Homo sapiens_hsa030601.22898051
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22111076
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.21422448
35Selenocompound metabolism_Homo sapiens_hsa004501.18037702
36RNA degradation_Homo sapiens_hsa030181.15851209
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14421792
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07984598
39Fanconi anemia pathway_Homo sapiens_hsa034601.06206174
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06129676
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06123717
42Measles_Homo sapiens_hsa051621.05783036
43Ether lipid metabolism_Homo sapiens_hsa005651.01776333
44Staphylococcus aureus infection_Homo sapiens_hsa051500.98051721
45Alzheimers disease_Homo sapiens_hsa050100.97101704
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94299447
47Regulation of autophagy_Homo sapiens_hsa041400.91609775
48Viral myocarditis_Homo sapiens_hsa054160.91224201
49Butanoate metabolism_Homo sapiens_hsa006500.86800049
50Basal transcription factors_Homo sapiens_hsa030220.85846804
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83809073
52Huntingtons disease_Homo sapiens_hsa050160.83530266
53Tryptophan metabolism_Homo sapiens_hsa003800.83345394
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82855790
55Arachidonic acid metabolism_Homo sapiens_hsa005900.80640235
56Peroxisome_Homo sapiens_hsa041460.79793476
57Systemic lupus erythematosus_Homo sapiens_hsa053220.78554088
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77769990
59Leishmaniasis_Homo sapiens_hsa051400.75717953
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74061225
61Herpes simplex infection_Homo sapiens_hsa051680.73568888
62One carbon pool by folate_Homo sapiens_hsa006700.73216993
63Olfactory transduction_Homo sapiens_hsa047400.70149408
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.68596150
65Chemical carcinogenesis_Homo sapiens_hsa052040.65815481
66Morphine addiction_Homo sapiens_hsa050320.65109373
67B cell receptor signaling pathway_Homo sapiens_hsa046620.64995611
68Sulfur metabolism_Homo sapiens_hsa009200.61193392
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60321946
70Nicotine addiction_Homo sapiens_hsa050330.59594995
71Cardiac muscle contraction_Homo sapiens_hsa042600.59036998
72Pyrimidine metabolism_Homo sapiens_hsa002400.58605455
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.57399919
74Retinol metabolism_Homo sapiens_hsa008300.56324715
75African trypanosomiasis_Homo sapiens_hsa051430.56047641
76Purine metabolism_Homo sapiens_hsa002300.56040987
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52917036
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49506770
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49195482
80Glycerolipid metabolism_Homo sapiens_hsa005610.48442789
81Chemokine signaling pathway_Homo sapiens_hsa040620.45718912
82Nucleotide excision repair_Homo sapiens_hsa034200.45098179
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43050097
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41290252
85Collecting duct acid secretion_Homo sapiens_hsa049660.40709856
86Osteoclast differentiation_Homo sapiens_hsa043800.38430519
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37863957
88Epstein-Barr virus infection_Homo sapiens_hsa051690.33945007
89Tuberculosis_Homo sapiens_hsa051520.32185811
90Serotonergic synapse_Homo sapiens_hsa047260.31247933
91Fat digestion and absorption_Homo sapiens_hsa049750.30965132
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29527527
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29507843
94Malaria_Homo sapiens_hsa051440.28259697
95Propanoate metabolism_Homo sapiens_hsa006400.26760237
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.26458340
97Metabolic pathways_Homo sapiens_hsa011000.26343393
98Base excision repair_Homo sapiens_hsa034100.26188476
99Taste transduction_Homo sapiens_hsa047420.25962146
100ABC transporters_Homo sapiens_hsa020100.24769097

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