APOBEC3F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA deamination (GO:0045006)7.13271466
2* cytidine metabolic process (GO:0046087)6.12668269
3* cytidine catabolic process (GO:0006216)6.12668269
4* cytidine deamination (GO:0009972)6.12668269
5* regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.84670131
6* pyrimidine ribonucleoside catabolic process (GO:0046133)5.30019866
7cellular response to interleukin-15 (GO:0071350)4.74139004
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.55256819
9positive regulation of gamma-delta T cell activation (GO:0046645)4.45252675
10regulation of B cell receptor signaling pathway (GO:0050855)4.36234570
11negative T cell selection (GO:0043383)4.22373906
12response to interleukin-15 (GO:0070672)4.16799552
13regulation of regulatory T cell differentiation (GO:0045589)4.15075692
14positive regulation of alpha-beta T cell proliferation (GO:0046641)4.05761549
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.02599782
16positive regulation of B cell differentiation (GO:0045579)4.00825324
17regulation of alpha-beta T cell proliferation (GO:0046640)3.99289040
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85075285
19antigen processing and presentation of endogenous antigen (GO:0019883)3.84549374
20T cell migration (GO:0072678)3.83802811
21response to interferon-beta (GO:0035456)3.79831810
22* positive regulation of defense response to virus by host (GO:0002230)3.78474275
23negative regulation of cell killing (GO:0031342)3.74218644
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.74218644
25regulation of B cell differentiation (GO:0045577)3.73506684
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.73112351
27negative thymic T cell selection (GO:0045060)3.70787258
28positive T cell selection (GO:0043368)3.58961308
29positive thymic T cell selection (GO:0045059)3.57267911
30regulation of chronic inflammatory response (GO:0002676)3.55639754
31* negative regulation of viral genome replication (GO:0045071)3.55176013
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53373676
33regulation of T cell mediated cytotoxicity (GO:0001914)3.52532067
34positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.44303952
35cellular response to interferon-beta (GO:0035458)3.37790042
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.37447432
37negative regulation of T cell mediated immunity (GO:0002710)3.36914373
38negative regulation of B cell proliferation (GO:0030889)3.32878869
39positive regulation of calcium-mediated signaling (GO:0050850)3.30690118
40regulation of leukocyte mediated cytotoxicity (GO:0001910)3.30676079
41cellular response to type I interferon (GO:0071357)3.23593033
42type I interferon signaling pathway (GO:0060337)3.23593033
43regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.23451577
44regulation of natural killer cell mediated immunity (GO:0002715)3.23451577
45response to type I interferon (GO:0034340)3.23298451
46positive regulation of cell killing (GO:0031343)3.19076382
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.18821313
48interferon-gamma production (GO:0032609)3.17724547
49regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.17179990
50regulation of gamma-delta T cell activation (GO:0046643)3.16157966
51positive regulation of natural killer cell mediated immunity (GO:0002717)3.13488932
52regulation of cell killing (GO:0031341)3.12562439
53regulation of gamma-delta T cell differentiation (GO:0045586)3.12059784
54immunoglobulin mediated immune response (GO:0016064)3.11626862
55regulation of interleukin-2 biosynthetic process (GO:0045076)3.03487560
56positive regulation of interleukin-17 production (GO:0032740)3.02315872
57positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.00344492
58mast cell activation (GO:0045576)2.98762272
59tolerance induction (GO:0002507)2.97512406
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96509447
61regulation of T cell receptor signaling pathway (GO:0050856)2.94797918
62T cell selection (GO:0045058)2.92662023
63positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.92494765
64thymic T cell selection (GO:0045061)2.91340470
65regulation of T cell tolerance induction (GO:0002664)2.91286560
66negative regulation of T cell apoptotic process (GO:0070233)2.90624377
67antigen processing and presentation via MHC class Ib (GO:0002475)2.87854329
68antigen receptor-mediated signaling pathway (GO:0050851)2.86934862
69B cell mediated immunity (GO:0019724)2.86675414
70lymphocyte chemotaxis (GO:0048247)2.85996108
71T cell costimulation (GO:0031295)2.85620527
72negative regulation by host of viral transcription (GO:0043922)2.85007242
73regulation of lymphocyte chemotaxis (GO:1901623)2.84284680
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82468813
75* pyrimidine nucleoside catabolic process (GO:0046135)2.81900119
76lymphocyte costimulation (GO:0031294)2.81378248
77regulation of T-helper 1 type immune response (GO:0002825)2.77334972
78platelet dense granule organization (GO:0060155)2.76649352
79B cell receptor signaling pathway (GO:0050853)2.75092872
80regulation of T-helper 1 cell differentiation (GO:0045625)2.73591131
81T cell receptor signaling pathway (GO:0050852)2.73586469
82positive regulation of lymphocyte migration (GO:2000403)2.73014408
83Arp2/3 complex-mediated actin nucleation (GO:0034314)2.71332952
84positive regulation of T cell mediated immunity (GO:0002711)2.70978192
85negative regulation of B cell activation (GO:0050869)2.70248059
86cellular defense response (GO:0006968)2.69600248
87regulation of activation of Janus kinase activity (GO:0010533)2.68388623
88leukocyte aggregation (GO:0070486)2.67028556
89* regulation of viral genome replication (GO:0045069)2.66732021
90* regulation of defense response to virus by host (GO:0050691)2.64747715
91positive regulation of T-helper 1 type immune response (GO:0002827)2.63514579
92positive regulation of tolerance induction (GO:0002645)2.62961568
93positive regulation of interleukin-8 secretion (GO:2000484)2.62686496
94negative regulation of interleukin-12 production (GO:0032695)2.62334916
95regulation of alpha-beta T cell activation (GO:0046634)2.61381827
96positive regulation of lymphocyte mediated immunity (GO:0002708)2.59135771
97regulation of T cell mediated immunity (GO:0002709)2.58654069
98activated T cell proliferation (GO:0050798)2.58653304
99positive regulation of immunoglobulin mediated immune response (GO:0002891)2.57208893
100positive regulation of B cell mediated immunity (GO:0002714)2.57208893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.11160731
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.26367387
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.52137872
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28761476
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22613084
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65353928
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.29466130
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93509052
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82566980
10MYB_26560356_Chip-Seq_TH2_Human2.54088940
11RUNX_20019798_ChIP-Seq_JUKART_Human2.52272183
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.48585165
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46110723
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36518778
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.20269790
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19696265
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.12106446
18GATA3_26560356_Chip-Seq_TH2_Human2.09132819
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.08687425
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02368694
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98950983
22ZNF274_21170338_ChIP-Seq_K562_Hela1.98939798
23VDR_23849224_ChIP-Seq_CD4+_Human1.97229280
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97010522
25GATA3_27048872_Chip-Seq_THYMUS_Human1.96665354
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94742594
27VDR_22108803_ChIP-Seq_LS180_Human1.89844185
28MYB_26560356_Chip-Seq_TH1_Human1.85188400
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78005839
30SPI1_23547873_ChIP-Seq_NB4_Human1.76334773
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74142474
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73495465
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.72950591
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67218632
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.63819977
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59124336
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58418323
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57684241
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55182979
40FOXP3_21729870_ChIP-Seq_TREG_Human1.52674996
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.51203948
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49868281
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32482274
44* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.31302459
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30215331
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29710924
47UTX_26944678_Chip-Seq_JUKART_Human1.29549178
48SCL_19346495_ChIP-Seq_HPC-7_Human1.27846477
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27305475
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26217152
51MAF_26560356_Chip-Seq_TH1_Human1.25821889
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24670642
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24301009
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21655956
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20667814
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16188764
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16135386
58MYC_18940864_ChIP-ChIP_HL60_Human1.15638634
59GATA3_26560356_Chip-Seq_TH1_Human1.15413207
60* MAF_26560356_Chip-Seq_TH2_Human1.14894256
61FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12651787
62* GATA3_21878914_ChIP-Seq_MCF-7_Human1.12098780
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09489164
64ELK1_19687146_ChIP-ChIP_HELA_Human1.09141835
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08698190
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.07223719
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07175977
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06621760
69TP53_22573176_ChIP-Seq_HFKS_Human1.05617328
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04916339
71NANOG_20526341_ChIP-Seq_ESCs_Human1.03417005
72BCL6_27268052_Chip-Seq_Bcells_Human1.02540446
73CIITA_25753668_ChIP-Seq_RAJI_Human1.02192423
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.00196583
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00196583
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99963230
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98611004
78* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98441580
79P300_27268052_Chip-Seq_Bcells_Human0.97326227
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96959081
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96427343
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95271095
83TAF2_19829295_ChIP-Seq_ESCs_Human0.95127762
84IRF1_19129219_ChIP-ChIP_H3396_Human0.92962832
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92919935
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92658211
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.92304504
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91832143
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.91358075
90AR_20517297_ChIP-Seq_VCAP_Human0.91108273
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85859155
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83318059
93SMRT_27268052_Chip-Seq_Bcells_Human0.82456141
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.81322327
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80957081
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80254297
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80231718
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79500708
99STAT1_20625510_ChIP-Seq_HELA_Human0.78565694
100ERG_20517297_ChIP-Seq_VCAP_Human0.78070774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.08118209
2MP0001835_abnormal_antigen_presentation4.04628528
3MP0000685_abnormal_immune_system3.20265746
4MP0009785_altered_susceptibility_to3.19553666
5MP0001800_abnormal_humoral_immune3.13014863
6MP0001790_abnormal_immune_system3.09839885
7MP0005387_immune_system_phenotype3.09839885
8MP0003763_abnormal_thymus_physiology3.04854328
9MP0005000_abnormal_immune_tolerance3.04471079
10MP0002148_abnormal_hypersensitivity_rea2.90167916
11MP0001873_stomach_inflammation2.87383621
12MP0002723_abnormal_immune_serum2.67320069
13MP0003436_decreased_susceptibility_to2.64140880
14MP0003724_increased_susceptibility_to2.59750504
15MP0005025_abnormal_response_to2.52547893
16MP0002420_abnormal_adaptive_immunity2.51529690
17MP0002452_abnormal_antigen_presenting2.48646713
18MP0001819_abnormal_immune_cell2.48610247
19MP0006082_CNS_inflammation2.33400098
20MP0002138_abnormal_hepatobiliary_system2.20718818
21MP0009333_abnormal_splenocyte_physiolog2.14509659
22MP0002398_abnormal_bone_marrow2.09636216
23MP0000716_abnormal_immune_system1.98779332
24MP0002405_respiratory_system_inflammati1.97384538
25MP0002419_abnormal_innate_immunity1.91125973
26MP0005464_abnormal_platelet_physiology1.89976153
27MP0010155_abnormal_intestine_physiology1.87919330
28MP0000689_abnormal_spleen_morphology1.83125620
29MP0001845_abnormal_inflammatory_respons1.79264350
30MP0003866_abnormal_defecation1.76934067
31MP0000372_irregular_coat_pigmentation1.72084919
32MP0002722_abnormal_immune_system1.65957367
33MP0002163_abnormal_gland_morphology1.62348045
34MP0000703_abnormal_thymus_morphology1.57778691
35MP0002429_abnormal_blood_cell1.57345628
36MP0005310_abnormal_salivary_gland1.55337536
37MP0005084_abnormal_gallbladder_morpholo1.52152511
38MP0003195_calcinosis1.48117913
39MP0009764_decreased_sensitivity_to1.40986693
40MP0008469_abnormal_protein_level1.40639345
41MP0002166_altered_tumor_susceptibility1.40019965
42MP0002933_joint_inflammation1.38669316
43MP0000465_gastrointestinal_hemorrhage1.33242416
44MP0005645_abnormal_hypothalamus_physiol1.31747690
45MP0001853_heart_inflammation1.31068570
46MP0002254_reproductive_system_inflammat1.31065760
47MP0003045_fibrosis1.30080798
48MP0005075_abnormal_melanosome_morpholog1.28552591
49MP0001533_abnormal_skeleton_physiology1.24475297
50MP0008872_abnormal_physiological_respon1.22624182
51MP0002277_abnormal_respiratory_mucosa1.18075073
52MP0002006_tumorigenesis1.15723825
53MP0004947_skin_inflammation1.14209532
54MP0002876_abnormal_thyroid_physiology1.07677385
55MP0002693_abnormal_pancreas_physiology1.06532652
56MP0008877_abnormal_DNA_methylation1.04615866
57MP0002102_abnormal_ear_morphology0.99402691
58MP0003303_peritoneal_inflammation0.99200208
59MP0002234_abnormal_pharynx_morphology0.98289170
60MP0003806_abnormal_nucleotide_metabolis0.97586297
61MP0009763_increased_sensitivity_to0.95324022
62MP0005379_endocrine/exocrine_gland_phen0.94282329
63MP0001919_abnormal_reproductive_system0.91277555
64MP0003786_premature_aging0.91212630
65MP0003183_abnormal_peptide_metabolism0.90142623
66MP0004142_abnormal_muscle_tone0.88984260
67MP0001663_abnormal_digestive_system0.85746240
68MP0004381_abnormal_hair_follicle0.84309337
69MP0006054_spinal_hemorrhage0.82104357
70MP0009765_abnormal_xenobiotic_induced0.81280420
71MP0002132_abnormal_respiratory_system0.80054464
72MP0005174_abnormal_tail_pigmentation0.79125180
73MP0003646_muscle_fatigue0.79041330
74MP0002139_abnormal_hepatobiliary_system0.76570238
75MP0008875_abnormal_xenobiotic_pharmacok0.76369868
76MP0002837_dystrophic_cardiac_calcinosis0.73690652
77MP0002019_abnormal_tumor_incidence0.68460735
78MP0003252_abnormal_bile_duct0.67659885
79MP0002653_abnormal_ependyma_morphology0.67285833
80MP0001765_abnormal_ion_homeostasis0.66061935
81MP0008873_increased_physiological_sensi0.64554104
82MP0004510_myositis0.63423283
83MP0005636_abnormal_mineral_homeostasis0.63016214
84MP0002136_abnormal_kidney_physiology0.62619757
85MP0009643_abnormal_urine_homeostasis0.60836794
86MP0001986_abnormal_taste_sensitivity0.60210101
87MP0001501_abnormal_sleep_pattern0.59641814
88MP0008004_abnormal_stomach_pH0.58514407
89MP0003011_delayed_dark_adaptation0.58193733
90MP0005389_reproductive_system_phenotype0.57980796
91MP0005319_abnormal_enzyme/_coenzyme0.55615620
92MP0003075_altered_response_to0.55573954
93MP0005410_abnormal_fertilization0.55405844
94MP0003787_abnormal_imprinting0.54808836
95MP0000343_altered_response_to0.54101696
96MP0006036_abnormal_mitochondrial_physio0.53517239
97MP0005166_decreased_susceptibility_to0.52561600
98MP0003448_altered_tumor_morphology0.51861731
99MP0006072_abnormal_retinal_apoptosis0.51454362
100MP0002928_abnormal_bile_duct0.50510610

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)5.33805627
2Abnormality of T cell number (HP:0011839)5.25650177
3Autoimmune hemolytic anemia (HP:0001890)5.12025131
4Increased IgM level (HP:0003496)4.73387873
5T lymphocytopenia (HP:0005403)4.47202544
6Abnormality of T cells (HP:0002843)4.46484605
7Stomatitis (HP:0010280)4.23610325
8Autoimmune thrombocytopenia (HP:0001973)4.20166225
9IgG deficiency (HP:0004315)4.18041678
10Elevated erythrocyte sedimentation rate (HP:0003565)4.12186829
11Abnormality of T cell physiology (HP:0011840)4.10147547
12Agammaglobulinemia (HP:0004432)3.75113335
13Optic neuritis (HP:0100653)3.69154829
14Retrobulbar optic neuritis (HP:0100654)3.69154829
15Chronic mucocutaneous candidiasis (HP:0002728)3.67460356
16Recurrent cutaneous fungal infections (HP:0011370)3.67460356
17Abnormality of eosinophils (HP:0001879)3.52310951
18Encephalitis (HP:0002383)3.48126653
19Panhypogammaglobulinemia (HP:0003139)3.48102491
20Eosinophilia (HP:0001880)3.46251917
21Recurrent fungal infections (HP:0002841)3.41783378
22Severe combined immunodeficiency (HP:0004430)3.36595674
23Myositis (HP:0100614)3.34350992
24Vasculitis (HP:0002633)3.28203235
25Meningitis (HP:0001287)3.23843965
26Orchitis (HP:0100796)3.23176268
27Granulocytopenia (HP:0001913)2.95679997
28Recurrent viral infections (HP:0004429)2.94748926
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.93414385
30Leukocytosis (HP:0001974)2.85538453
31Recurrent bronchitis (HP:0002837)2.84699419
32Chronic diarrhea (HP:0002028)2.77290210
33Hypoproteinemia (HP:0003075)2.72778058
34Lymphopenia (HP:0001888)2.66773978
35Abnormality of the prostate (HP:0008775)2.61237099
36IgM deficiency (HP:0002850)2.59571002
37Thyroiditis (HP:0100646)2.58359018
38Keratoconjunctivitis (HP:0001096)2.58015498
39Combined immunodeficiency (HP:0005387)2.56917334
40Pulmonary infiltrates (HP:0002113)2.56172045
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55104049
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55104049
43Aplastic anemia (HP:0001915)2.55057092
44Hypochromic anemia (HP:0001931)2.53986423
45Mitochondrial inheritance (HP:0001427)2.50255941
46Hypergammaglobulinemia (HP:0010702)2.45914665
47Abnormality of B cell number (HP:0010975)2.45743875
48Neutropenia (HP:0001875)2.44968210
49Congenital stationary night blindness (HP:0007642)2.44946965
50Keratoconjunctivitis sicca (HP:0001097)2.40967137
51Hemoptysis (HP:0002105)2.37999546
52Recurrent skin infections (HP:0001581)2.33777669
533-Methylglutaconic aciduria (HP:0003535)2.30070694
54Petechiae (HP:0000967)2.29597741
55Acute necrotizing encephalopathy (HP:0006965)2.29262711
56IgA deficiency (HP:0002720)2.28965222
57Hepatocellular necrosis (HP:0001404)2.23177795
58Joint swelling (HP:0001386)2.19702426
59Recurrent sinusitis (HP:0011108)2.15194763
60Gastrointestinal infarctions (HP:0005244)2.14293283
61B lymphocytopenia (HP:0010976)2.12277172
62Increased CSF lactate (HP:0002490)2.11851064
63Mediastinal lymphadenopathy (HP:0100721)2.11446547
64Pancreatic cysts (HP:0001737)2.10151893
65Abnormal mitochondria in muscle tissue (HP:0008316)2.08696477
66Abolished electroretinogram (ERG) (HP:0000550)2.07607443
67Obstructive lung disease (HP:0006536)2.06766225
68Chronic obstructive pulmonary disease (HP:0006510)2.06766225
69Gangrene (HP:0100758)2.05961961
70Anorexia (HP:0002039)2.04054607
71Recurrent bacterial skin infections (HP:0005406)2.02782006
72Hepatic necrosis (HP:0002605)1.99031982
73Renal cortical cysts (HP:0000803)1.97482090
74Abnormality of macrophages (HP:0004311)1.96528507
75Eczematoid dermatitis (HP:0000976)1.96497849
76Abnormality of the pleura (HP:0002103)1.95150515
77Recurrent abscess formation (HP:0002722)1.95002351
78Methylmalonic acidemia (HP:0002912)1.94681650
79Progressive macrocephaly (HP:0004481)1.93385256
80Prolonged bleeding time (HP:0003010)1.92579236
81Skin rash (HP:0000988)1.89880582
82Abnormal rod and cone electroretinograms (HP:0008323)1.88674713
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87292640
84Pustule (HP:0200039)1.85951477
85Methylmalonic aciduria (HP:0012120)1.85207520
86Chronic otitis media (HP:0000389)1.84942943
87Acute encephalopathy (HP:0006846)1.84874815
88Arterial thrombosis (HP:0004420)1.83540970
89Urticaria (HP:0001025)1.83089708
90Hypoplasia of the uterus (HP:0000013)1.81968556
91Bronchitis (HP:0012387)1.81831824
92Acute hepatic failure (HP:0006554)1.81557550
93Lymphoma (HP:0002665)1.80530675
94Abnormality of the renal cortex (HP:0011035)1.79034946
95Pancytopenia (HP:0001876)1.78780883
96Polyneuropathy (HP:0001271)1.77048258
97Chest pain (HP:0100749)1.76597212
98Keratitis (HP:0000491)1.72372858
99Gastrointestinal stroma tumor (HP:0100723)1.71611768
100Abnormality of midbrain morphology (HP:0002418)1.69316632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.09294690
2TXK5.07984074
3MAP4K13.72837769
4MST42.69250582
5ADRBK22.53676896
6TAOK32.51749579
7KDR2.30477680
8RIPK42.17718494
9ZAK2.15969883
10SYK1.99159984
11IKBKB1.93687078
12FRK1.82885631
13ITK1.80115641
14IKBKE1.77819961
15KIT1.76640324
16BMPR21.75278961
17PIK3CA1.70806555
18IRAK41.62023495
19BTK1.57384818
20FES1.56932455
21GRK11.55894191
22GRK61.55776827
23GRK71.55474236
24NUAK11.52617324
25PRKCQ1.51503292
26TEC1.50390264
27JAK31.48890190
28MARK31.46419305
29ZAP701.40945621
30VRK21.40254965
31BMPR1B1.38422419
32EIF2AK31.37966697
33ACVR1B1.34886891
34LCK1.33386523
35TNK21.30746538
36TBK11.27986815
37WNK41.27934756
38TESK21.24983611
39BCKDK1.21829018
40TYK21.17621347
41LYN1.16330658
42STK101.15674634
43VRK11.14591279
44MAP3K141.13957364
45CSK1.12555825
46CSF1R1.11144406
47MAP2K61.03447949
48MAP4K20.99486407
49JAK10.97836725
50OXSR10.92488297
51INSRR0.92058011
52MAPKAPK30.90612511
53CAMKK20.90556281
54HCK0.90101667
55BLK0.83903678
56MATK0.75229068
57PIM10.73041580
58NLK0.70681187
59ADRBK10.66935649
60DAPK20.65826987
61PIK3CG0.64109387
62BUB10.63563678
63MAP3K120.60008609
64JAK20.56224746
65IRAK10.54364050
66RPS6KA50.52664319
67TNIK0.52651486
68MAP3K110.51663649
69CHUK0.51257070
70PINK10.49303940
71GRK50.48819435
72TRIM280.44512805
73FGR0.43953779
74IGF1R0.42944449
75MAPK120.40967679
76WNK30.40572887
77SIK30.38175640
78PTK2B0.37822602
79STK160.37173763
80MAP2K30.37111893
81PASK0.36310376
82PRKCI0.34305970
83DAPK10.32577890
84INSR0.32047588
85MELK0.31740143
86MAPKAPK20.30839106
87NME20.29171697
88ABL10.28663973
89PIM20.28182978
90TGFBR10.27122832
91FYN0.26355149
92MYLK0.26141171
93PRKCD0.25738716
94MAPK110.25161233
95CDK190.25079995
96MAP3K50.22525157
97PRKCA0.21669521
98EPHA30.20549543
99PDK10.20522109
100STK390.20479540

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.18185622
2Graft-versus-host disease_Homo sapiens_hsa053323.89911140
3Allograft rejection_Homo sapiens_hsa053303.83376409
4Autoimmune thyroid disease_Homo sapiens_hsa053203.72780841
5Type I diabetes mellitus_Homo sapiens_hsa049403.11999973
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.85877030
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72035963
8Antigen processing and presentation_Homo sapiens_hsa046122.71179635
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.59528037
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.30107035
11Asthma_Homo sapiens_hsa053102.26334815
12Proteasome_Homo sapiens_hsa030502.15200050
13Hematopoietic cell lineage_Homo sapiens_hsa046402.10536664
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.92386292
15T cell receptor signaling pathway_Homo sapiens_hsa046601.90360984
16Measles_Homo sapiens_hsa051621.83768845
17Rheumatoid arthritis_Homo sapiens_hsa053231.73113167
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68171037
19Oxidative phosphorylation_Homo sapiens_hsa001901.66378792
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49158503
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40396253
22Parkinsons disease_Homo sapiens_hsa050121.30308256
23African trypanosomiasis_Homo sapiens_hsa051431.28947957
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28869684
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27862580
26Leishmaniasis_Homo sapiens_hsa051401.26751412
27Herpes simplex infection_Homo sapiens_hsa051681.26674472
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25990670
29Protein export_Homo sapiens_hsa030601.25741772
30Viral myocarditis_Homo sapiens_hsa054161.24539435
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20668718
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20386729
33RNA polymerase_Homo sapiens_hsa030201.19904514
34Caffeine metabolism_Homo sapiens_hsa002321.18866828
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16512404
36Staphylococcus aureus infection_Homo sapiens_hsa051501.14271451
37Linoleic acid metabolism_Homo sapiens_hsa005911.13480078
38Homologous recombination_Homo sapiens_hsa034401.06173115
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.05878891
40B cell receptor signaling pathway_Homo sapiens_hsa046621.05228078
41Malaria_Homo sapiens_hsa051441.05116344
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97271930
43Osteoclast differentiation_Homo sapiens_hsa043800.94144900
44Influenza A_Homo sapiens_hsa051640.91277348
45Ribosome_Homo sapiens_hsa030100.89984782
46Phototransduction_Homo sapiens_hsa047440.89044625
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88468304
48Chemokine signaling pathway_Homo sapiens_hsa040620.80320699
49RNA degradation_Homo sapiens_hsa030180.75774012
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.72884281
51Alzheimers disease_Homo sapiens_hsa050100.72058297
52Systemic lupus erythematosus_Homo sapiens_hsa053220.71716408
53Tuberculosis_Homo sapiens_hsa051520.71331422
54TNF signaling pathway_Homo sapiens_hsa046680.68387273
55Epstein-Barr virus infection_Homo sapiens_hsa051690.67694553
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67675174
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65049791
58Nitrogen metabolism_Homo sapiens_hsa009100.62262660
59Legionellosis_Homo sapiens_hsa051340.59885657
60Peroxisome_Homo sapiens_hsa041460.59382253
61Butanoate metabolism_Homo sapiens_hsa006500.57121242
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56899604
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56100105
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55793475
65Apoptosis_Homo sapiens_hsa042100.55200640
66Sulfur metabolism_Homo sapiens_hsa009200.55036319
67Toxoplasmosis_Homo sapiens_hsa051450.52542133
68Tryptophan metabolism_Homo sapiens_hsa003800.52008973
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51245051
70Huntingtons disease_Homo sapiens_hsa050160.51012958
71Arachidonic acid metabolism_Homo sapiens_hsa005900.50158033
72Shigellosis_Homo sapiens_hsa051310.47799874
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47575844
74Basal transcription factors_Homo sapiens_hsa030220.46807568
75Pyrimidine metabolism_Homo sapiens_hsa002400.46326092
76Ether lipid metabolism_Homo sapiens_hsa005650.45748894
77Platelet activation_Homo sapiens_hsa046110.44893537
78One carbon pool by folate_Homo sapiens_hsa006700.44628074
79Salmonella infection_Homo sapiens_hsa051320.44512547
80Collecting duct acid secretion_Homo sapiens_hsa049660.41607652
81Fanconi anemia pathway_Homo sapiens_hsa034600.40405526
82Hepatitis B_Homo sapiens_hsa051610.37136614
83Non-homologous end-joining_Homo sapiens_hsa034500.35476802
84Propanoate metabolism_Homo sapiens_hsa006400.35076476
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34579221
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34406401
87Chemical carcinogenesis_Homo sapiens_hsa052040.34164704
88Olfactory transduction_Homo sapiens_hsa047400.32450680
89Purine metabolism_Homo sapiens_hsa002300.32291769
90Selenocompound metabolism_Homo sapiens_hsa004500.31489567
91Pertussis_Homo sapiens_hsa051330.30413174
92HTLV-I infection_Homo sapiens_hsa051660.29765023
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29636117
94Nucleotide excision repair_Homo sapiens_hsa034200.27455497
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26218211
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24250833
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21136478
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20897912
99Regulation of autophagy_Homo sapiens_hsa041400.20219536
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.17651514

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