APOBEC3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cytidine deamination (GO:0009972)7.00850909
2* cytidine metabolic process (GO:0046087)7.00850909
3* cytidine catabolic process (GO:0006216)7.00850909
4* pyrimidine ribonucleoside catabolic process (GO:0046133)6.23047297
5positive regulation of gamma-delta T cell activation (GO:0046645)5.71959360
6cellular response to interleukin-15 (GO:0071350)5.68117287
7* DNA deamination (GO:0045006)5.45326916
8regulation of B cell receptor signaling pathway (GO:0050855)5.36175182
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.35828033
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15314056
11response to interleukin-15 (GO:0070672)5.13215562
12* regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.94945157
13negative T cell selection (GO:0043383)4.87216276
14positive thymic T cell selection (GO:0045059)4.83520313
15regulation of regulatory T cell differentiation (GO:0045589)4.77658058
16positive T cell selection (GO:0043368)4.73041401
17negative regulation of cell killing (GO:0031342)4.69230620
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.69230620
19T cell migration (GO:0072678)4.66732315
20positive regulation of B cell differentiation (GO:0045579)4.49918856
21regulation of gamma-delta T cell differentiation (GO:0045586)4.44772056
22negative thymic T cell selection (GO:0045060)4.38699123
23regulation of chronic inflammatory response (GO:0002676)4.36363178
24regulation of B cell differentiation (GO:0045577)4.35325020
25regulation of gamma-delta T cell activation (GO:0046643)4.32484340
26regulation of natural killer cell mediated immunity (GO:0002715)4.27177140
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.27177140
28positive regulation of natural killer cell mediated immunity (GO:0002717)4.25737806
29negative regulation by host of viral transcription (GO:0043922)4.23453393
30regulation of lymphocyte chemotaxis (GO:1901623)4.20721839
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20439026
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.10119103
33antigen processing and presentation of endogenous antigen (GO:0019883)4.08444719
34positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.07403993
35thymic T cell selection (GO:0045061)4.04895809
36regulation of T cell tolerance induction (GO:0002664)4.04195521
37* negative regulation of viral genome replication (GO:0045071)4.02277503
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.01569408
39regulation of alpha-beta T cell proliferation (GO:0046640)3.98108673
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.93524590
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.90484113
42activated T cell proliferation (GO:0050798)3.90205538
43positive regulation of T cell mediated cytotoxicity (GO:0001916)3.90049104
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85219737
45regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.84032014
46T cell selection (GO:0045058)3.81162528
47positive regulation of cell killing (GO:0031343)3.80178740
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.80042217
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.79926651
50regulation of T cell mediated cytotoxicity (GO:0001914)3.79403712
51negative regulation of B cell proliferation (GO:0030889)3.77749935
52positive regulation of lymphocyte migration (GO:2000403)3.75198113
53positive regulation of calcium-mediated signaling (GO:0050850)3.73748200
54regulation of cell killing (GO:0031341)3.66347598
55negative regulation of T cell apoptotic process (GO:0070233)3.66263355
56regulation of interleukin-2 biosynthetic process (GO:0045076)3.66151418
57T cell costimulation (GO:0031295)3.65946866
58lymphocyte costimulation (GO:0031294)3.62248951
59lymphocyte chemotaxis (GO:0048247)3.59982709
60interferon-gamma production (GO:0032609)3.58881421
61positive regulation of tolerance induction (GO:0002645)3.58623014
62immunoglobulin mediated immune response (GO:0016064)3.56190949
63B cell receptor signaling pathway (GO:0050853)3.53611205
64positive regulation of interleukin-8 secretion (GO:2000484)3.53166932
65regulation of T cell receptor signaling pathway (GO:0050856)3.50197873
66type I interferon signaling pathway (GO:0060337)3.50122420
67cellular response to type I interferon (GO:0071357)3.50122420
68response to type I interferon (GO:0034340)3.48048307
69T cell receptor signaling pathway (GO:0050852)3.44397641
70eosinophil chemotaxis (GO:0048245)3.43608176
71antigen receptor-mediated signaling pathway (GO:0050851)3.43304910
72regulation of tolerance induction (GO:0002643)3.42787723
73regulation of T cell chemotaxis (GO:0010819)3.40939198
74positive regulation of T cell chemotaxis (GO:0010820)3.40939198
75response to interferon-beta (GO:0035456)3.40041838
76positive regulation of humoral immune response (GO:0002922)3.39734085
77regulation of activation of Janus kinase activity (GO:0010533)3.37634208
78regulation of interleukin-12 biosynthetic process (GO:0045075)3.34212967
79negative regulation of T cell mediated immunity (GO:0002710)3.33684397
80actin nucleation (GO:0045010)3.26652662
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25066010
82regulation of lymphocyte migration (GO:2000401)3.19847243
83B cell mediated immunity (GO:0019724)3.19357528
84regulation of isotype switching to IgG isotypes (GO:0048302)3.16702045
85lymphocyte migration (GO:0072676)3.13381878
86positive regulation of lymphocyte mediated immunity (GO:0002708)3.12968255
87negative regulation of interleukin-12 production (GO:0032695)3.12606467
88leukocyte aggregation (GO:0070486)3.11058949
89eosinophil migration (GO:0072677)3.09670725
90negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.08730202
91CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.08411401
92negative regulation of B cell activation (GO:0050869)3.07389573
93cellular defense response (GO:0006968)3.06987262
94* pyrimidine nucleoside catabolic process (GO:0046135)3.06050361
95mast cell activation (GO:0045576)3.01829035
96NIK/NF-kappaB signaling (GO:0038061)2.98728582
97macrophage chemotaxis (GO:0048246)2.96469126
98* regulation of viral genome replication (GO:0045069)2.95757615
99chemokine-mediated signaling pathway (GO:0070098)2.94768678
100positive regulation of T cell mediated immunity (GO:0002711)2.94051524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.25423282
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.13381377
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.33466600
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.00132196
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.80479745
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.95363569
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.79988655
8MYB_26560356_Chip-Seq_TH2_Human3.23828111
9RUNX_20019798_ChIP-Seq_JUKART_Human3.16016882
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.04764107
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80387456
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74038163
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66365277
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47820151
15MYB_26560356_Chip-Seq_TH1_Human2.42517513
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30845081
17GATA3_27048872_Chip-Seq_THYMUS_Human2.30702106
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26775355
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22567125
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.14492702
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08572510
22MAF_26560356_Chip-Seq_TH1_Human2.07368586
23GATA3_26560356_Chip-Seq_TH2_Human2.05993375
24SPI1_23547873_ChIP-Seq_NB4_Human1.97086745
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.96073858
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93434664
27UTX_26944678_Chip-Seq_JUKART_Human1.85390070
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84819194
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83207204
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81692794
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80029266
32MAF_26560356_Chip-Seq_TH2_Human1.74211805
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69253487
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65640285
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60391046
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57257155
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.54832316
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50689248
39VDR_23849224_ChIP-Seq_CD4+_Human1.49210604
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39636315
41CIITA_25753668_ChIP-Seq_RAJI_Human1.32952263
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.32683293
43GATA1_22025678_ChIP-Seq_K562_Human1.31221162
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28623786
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26175608
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.22264270
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21963260
48SCL_19346495_ChIP-Seq_HPC-7_Human1.15130290
49FOXP3_21729870_ChIP-Seq_TREG_Human1.13850871
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12883632
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.12243285
52SPI1_23127762_ChIP-Seq_K562_Human1.11143517
53GATA3_26560356_Chip-Seq_TH1_Human1.09862355
54MYC_22102868_ChIP-Seq_BL_Human1.07788547
55* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03905807
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02697130
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01848694
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01272756
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00806261
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00339920
61BCL6_27268052_Chip-Seq_Bcells_Human0.98736697
62VDR_24763502_ChIP-Seq_THP-1_Human0.98379274
63BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98124567
64EST1_17652178_ChIP-ChIP_JURKAT_Human0.97966117
65VDR_24787735_ChIP-Seq_THP-1_Human0.96451161
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94543300
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93528365
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89989722
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88821895
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88176896
71PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87861253
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87011107
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86192692
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85461805
75SMRT_27268052_Chip-Seq_Bcells_Human0.83590715
76VDR_22108803_ChIP-Seq_LS180_Human0.82553101
77P300_27268052_Chip-Seq_Bcells_Human0.82336055
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81747244
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81638687
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81249362
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80052596
82* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79882915
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79193909
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79177829
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77950950
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.77654749
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.76068424
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.75951366
89STAT1_20625510_ChIP-Seq_HELA_Human0.75106630
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74134300
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72610572
92NANOG_20526341_ChIP-Seq_ESCs_Human0.72136893
93TAF2_19829295_ChIP-Seq_ESCs_Human0.70939700
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.70836238
95ZNF274_21170338_ChIP-Seq_K562_Hela0.70803161
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.70176374
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.67435687
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.67389734
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67007540
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66893770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.86942681
2MP0001835_abnormal_antigen_presentation4.23627208
3MP0003763_abnormal_thymus_physiology3.85420436
4MP0009785_altered_susceptibility_to3.72358859
5MP0001800_abnormal_humoral_immune3.47821934
6MP0001790_abnormal_immune_system3.43478272
7MP0005387_immune_system_phenotype3.43478272
8MP0005000_abnormal_immune_tolerance3.34690683
9MP0000685_abnormal_immune_system3.19670800
10MP0006082_CNS_inflammation3.10596482
11MP0003436_decreased_susceptibility_to3.07246946
12MP0009333_abnormal_splenocyte_physiolog3.02662537
13MP0002148_abnormal_hypersensitivity_rea3.01105657
14MP0002723_abnormal_immune_serum2.95131930
15MP0002420_abnormal_adaptive_immunity2.85662712
16MP0005025_abnormal_response_to2.84277272
17MP0001873_stomach_inflammation2.80692622
18MP0001819_abnormal_immune_cell2.78674270
19MP0002452_abnormal_antigen_presenting2.67633596
20MP0002398_abnormal_bone_marrow2.32712007
21MP0000716_abnormal_immune_system2.24796394
22MP0003724_increased_susceptibility_to2.24252762
23MP0002405_respiratory_system_inflammati2.23961127
24MP0002419_abnormal_innate_immunity2.20191796
25MP0002166_altered_tumor_susceptibility2.06220932
26MP0010155_abnormal_intestine_physiology2.05979255
27MP0000689_abnormal_spleen_morphology1.95444128
28MP0003866_abnormal_defecation1.94294203
29MP0000703_abnormal_thymus_morphology1.91809951
30MP0002722_abnormal_immune_system1.87898849
31MP0001845_abnormal_inflammatory_respons1.84240617
32MP0005310_abnormal_salivary_gland1.79565154
33MP0001853_heart_inflammation1.77570823
34MP0002429_abnormal_blood_cell1.77150147
35MP0003045_fibrosis1.63872741
36MP0002138_abnormal_hepatobiliary_system1.61141253
37MP0002006_tumorigenesis1.58622932
38MP0005464_abnormal_platelet_physiology1.53392045
39MP0002933_joint_inflammation1.50095243
40MP0004947_skin_inflammation1.49283805
41MP0008469_abnormal_protein_level1.41300487
42MP0009764_decreased_sensitivity_to1.39532718
43MP0001533_abnormal_skeleton_physiology1.32951002
44MP0003303_peritoneal_inflammation1.30766999
45MP0003448_altered_tumor_morphology1.25354740
46MP0002277_abnormal_respiratory_mucosa1.23048571
47MP0002163_abnormal_gland_morphology1.22781474
48MP0005075_abnormal_melanosome_morpholog1.19662002
49MP0004381_abnormal_hair_follicle1.16768772
50MP0009763_increased_sensitivity_to1.10967795
51MP0000372_irregular_coat_pigmentation1.07021556
52MP0003300_gastrointestinal_ulcer1.06761645
53MP0000569_abnormal_digit_pigmentation0.97117049
54MP0002693_abnormal_pancreas_physiology0.88027956
55MP0002019_abnormal_tumor_incidence0.87679990
56MP0001919_abnormal_reproductive_system0.85841544
57MP0009765_abnormal_xenobiotic_induced0.84552471
58MP0003786_premature_aging0.83651431
59MP0000858_altered_metastatic_potential0.83418351
60MP0005645_abnormal_hypothalamus_physiol0.80598070
61MP0003806_abnormal_nucleotide_metabolis0.79718156
62MP0001501_abnormal_sleep_pattern0.75667587
63MP0002132_abnormal_respiratory_system0.74933121
64MP0008873_increased_physiological_sensi0.71511159
65MP0005166_decreased_susceptibility_to0.70491609
66MP0001663_abnormal_digestive_system0.69542502
67MP0001348_abnormal_lacrimal_gland0.67826759
68MP0000465_gastrointestinal_hemorrhage0.67466761
69MP0005379_endocrine/exocrine_gland_phen0.67175879
70MP0002396_abnormal_hematopoietic_system0.67005173
71MP0002876_abnormal_thyroid_physiology0.65459756
72MP0002998_abnormal_bone_remodeling0.65200161
73MP0003075_altered_response_to0.65083155
74MP0003183_abnormal_peptide_metabolism0.64532478
75MP0004510_myositis0.59908159
76MP0000015_abnormal_ear_pigmentation0.58497667
77MP0008872_abnormal_physiological_respon0.57775298
78MP0003195_calcinosis0.56888974
79MP0002136_abnormal_kidney_physiology0.54313436
80MP0003172_abnormal_lysosome_physiology0.53445833
81MP0005390_skeleton_phenotype0.51266622
82MP0003646_muscle_fatigue0.51208146
83MP0002095_abnormal_skin_pigmentation0.50756267
84MP0005174_abnormal_tail_pigmentation0.49526146
85MP0005584_abnormal_enzyme/coenzyme_acti0.48018691
86MP0001986_abnormal_taste_sensitivity0.47537902
87MP0001851_eye_inflammation0.46787440
88MP0002168_other_aberrant_phenotype0.46686979
89MP0004145_abnormal_muscle_electrophysio0.46150569
90MP0001765_abnormal_ion_homeostasis0.44643504
91MP0002254_reproductive_system_inflammat0.42480288
92MP0000604_amyloidosis0.41886526
93MP0009643_abnormal_urine_homeostasis0.41458152
94MP0003252_abnormal_bile_duct0.41369974
95MP0005389_reproductive_system_phenotype0.39998410
96MP0000490_abnormal_crypts_of0.38999240
97MP0005165_increased_susceptibility_to0.38479851
98MP0000371_diluted_coat_color0.37977125
99MP0003795_abnormal_bone_structure0.36164594
100MP0005319_abnormal_enzyme/_coenzyme0.35922931

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)6.54151748
2T lymphocytopenia (HP:0005403)6.44216977
3Abnormal delayed hypersensitivity skin test (HP:0002963)5.42903754
4Autoimmune hemolytic anemia (HP:0001890)5.17422006
5Abnormality of T cells (HP:0002843)4.98870125
6Elevated erythrocyte sedimentation rate (HP:0003565)4.98609200
7Increased IgM level (HP:0003496)4.68163685
8IgG deficiency (HP:0004315)4.64897218
9Stomatitis (HP:0010280)4.47331862
10Chronic mucocutaneous candidiasis (HP:0002728)4.28815337
11Recurrent cutaneous fungal infections (HP:0011370)4.28815337
12Meningitis (HP:0001287)4.19374983
13Severe combined immunodeficiency (HP:0004430)4.17344992
14Agammaglobulinemia (HP:0004432)4.01682316
15Recurrent fungal infections (HP:0002841)3.99079696
16Recurrent bronchitis (HP:0002837)3.98112823
17Encephalitis (HP:0002383)3.95062543
18Myositis (HP:0100614)3.91587547
19Optic neuritis (HP:0100653)3.88820818
20Retrobulbar optic neuritis (HP:0100654)3.88820818
21Abnormality of eosinophils (HP:0001879)3.88390273
22Aplastic anemia (HP:0001915)3.87813636
23Chronic diarrhea (HP:0002028)3.83093382
24Vasculitis (HP:0002633)3.81435856
25Pulmonary infiltrates (HP:0002113)3.70269548
26Abnormality of T cell physiology (HP:0011840)3.66437854
27Orchitis (HP:0100796)3.64911474
28Recurrent viral infections (HP:0004429)3.64065590
29Eosinophilia (HP:0001880)3.51051296
30Panhypogammaglobulinemia (HP:0003139)3.47118567
31Abnormality of macrophages (HP:0004311)3.46996586
32Autoimmune thrombocytopenia (HP:0001973)3.45840121
33Hypoproteinemia (HP:0003075)3.39807790
34Leukocytosis (HP:0001974)3.32443326
35Abnormality of the prostate (HP:0008775)3.32165287
36Combined immunodeficiency (HP:0005387)3.29288678
37Thyroiditis (HP:0100646)3.25228588
38Recurrent bacterial skin infections (HP:0005406)3.23904246
39Mediastinal lymphadenopathy (HP:0100721)3.23175033
40Abnormality of cells of the lymphoid lineage (HP:0012140)3.22387123
41Gastrointestinal infarctions (HP:0005244)3.21356406
42Chronic obstructive pulmonary disease (HP:0006510)3.20032199
43Obstructive lung disease (HP:0006536)3.20032199
44Recurrent skin infections (HP:0001581)3.19593404
45Granulocytopenia (HP:0001913)3.18377702
46Lymphopenia (HP:0001888)3.16082381
47Hemoptysis (HP:0002105)3.08316158
48Recurrent abscess formation (HP:0002722)3.07318264
49IgM deficiency (HP:0002850)2.99245221
50Eczematoid dermatitis (HP:0000976)2.86988619
51Chest pain (HP:0100749)2.83757904
52Gangrene (HP:0100758)2.83698407
53Keratoconjunctivitis sicca (HP:0001097)2.82002120
54Joint swelling (HP:0001386)2.80788188
55Keratoconjunctivitis (HP:0001096)2.79773979
56Abnormality of B cell number (HP:0010975)2.78046964
57Abnormality of the pleura (HP:0002103)2.72732018
58Pustule (HP:0200039)2.65083463
59Hypergammaglobulinemia (HP:0010702)2.63829101
60IgA deficiency (HP:0002720)2.63523867
61Hypoplasia of the thymus (HP:0000778)2.49610514
62Pulmonary embolism (HP:0002204)2.48514121
63Lymphoma (HP:0002665)2.47528186
64B lymphocytopenia (HP:0010976)2.39224295
65Skin rash (HP:0000988)2.37409311
66Bronchitis (HP:0012387)2.37323793
67Pulmonary fibrosis (HP:0002206)2.33408229
68Ureteral stenosis (HP:0000071)2.24270134
69Hypochromic anemia (HP:0001931)2.17171393
70Arterial thrombosis (HP:0004420)2.15884068
71Inflammation of the large intestine (HP:0002037)2.14742377
72Recurrent sinusitis (HP:0011108)2.12490642
73Ureteral obstruction (HP:0006000)2.11481055
74Urticaria (HP:0001025)2.11114514
75Anorexia (HP:0002039)2.09451102
76Acute hepatic failure (HP:0006554)2.08428894
77Polyneuropathy (HP:0001271)2.08418518
78Abnormality of the pericardium (HP:0001697)2.03425494
79Abnormality of male internal genitalia (HP:0000022)2.02437073
80Glomerulopathy (HP:0100820)1.98019393
81Chronic otitis media (HP:0000389)1.95934101
82Gastrointestinal inflammation (HP:0004386)1.94867553
83Hemiplegia (HP:0002301)1.94284216
84Alveolar cell carcinoma (HP:0006519)1.93748097
85Gastrointestinal stroma tumor (HP:0100723)1.92109442
86Keratitis (HP:0000491)1.91671033
87Increased IgE level (HP:0003212)1.91153536
883-Methylglutaconic aciduria (HP:0003535)1.90104550
89Abnormal albumin level (HP:0012116)1.87444726
90Hypoalbuminemia (HP:0003073)1.87444726
91Recurrent gram-negative bacterial infections (HP:0005420)1.85934522
92Colitis (HP:0002583)1.85907292
93Epistaxis (HP:0000421)1.80157826
94Recurrent otitis media (HP:0000403)1.79402917
95Neutropenia (HP:0001875)1.78573829
96Arthralgia (HP:0002829)1.76290344
97Restrictive lung disease (HP:0002091)1.75184233
98Petechiae (HP:0000967)1.74842354
99Oral leukoplakia (HP:0002745)1.71402546
100Verrucae (HP:0200043)1.69635553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.97531183
2MAP4K14.61053069
3KDR3.27510680
4TAOK32.79835795
5RIPK42.70189683
6FES2.60078130
7ITK2.49848903
8CSK2.18832346
9SYK2.16980660
10TLK12.00267859
11IKBKE1.93296763
12TESK21.87119435
13IKBKB1.82155940
14JAK31.78142690
15BTK1.77318772
16BLK1.74739060
17LCK1.72696528
18MST41.70628164
19ADRBK21.67406562
20BCKDK1.66399043
21PRKCQ1.64087994
22IRAK41.58452925
23GRK71.57057434
24TYK21.56873819
25MAP3K141.54349651
26TNK21.52465325
27ZAP701.50727141
28TBK11.49648071
29JAK11.44461813
30LYN1.41257382
31TEC1.37379664
32BMPR21.35740726
33KIT1.35479194
34GRK61.30956445
35NUAK11.30700721
36CSF1R1.24258115
37PIK3CA1.15190369
38MAP3K111.12666976
39EIF2AK31.09924877
40MATK1.06148282
41HCK1.03699865
42FRK0.99533814
43JAK20.98784037
44STK100.96031639
45MAP2K60.94405973
46ZAK0.85395101
47CAMKK20.81643925
48MARK30.76677228
49VRK10.70680086
50EPHA30.70576246
51MAP4K20.70176313
52PIM10.68242919
53ACVR1B0.66671078
54ERN10.66175097
55FYN0.63258647
56PIK3CG0.62003969
57MAPKAPK30.60877506
58GRK10.60641936
59CHUK0.58197368
60MAP3K130.57933885
61MAP3K120.57775534
62MAPK110.56135739
63SIK30.55563966
64PDK10.53779303
65VRK20.50011736
66RPS6KA50.49709790
67CLK10.47757163
68BMPR1B0.46424487
69PRKCH0.45443358
70IRAK10.45248292
71FGR0.44602074
72IGF1R0.44562623
73NLK0.44449995
74TYRO30.44414155
75TGFBR20.43798739
76DAPK20.41879469
77MAPKAPK20.39805360
78FGFR40.39475650
79INSR0.39118923
80MAP3K50.36844742
81HIPK20.36121251
82MAP2K30.32628808
83DAPK10.31780090
84FGFR30.31434442
85PRKCD0.28825050
86WNK40.28008204
87ABL10.27219646
88GRK50.26960899
89OXSR10.26317522
90CDK40.25899229
91MAPK120.25603319
92EPHB10.25511204
93SIK20.25251127
94ADRBK10.24601881
95INSRR0.20443497
96MAP3K30.19460981
97PASK0.18549857
98CDK190.18213315
99EIF2AK20.17713148
100MAPK30.17440070

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.32794921
2Graft-versus-host disease_Homo sapiens_hsa053324.74350492
3Autoimmune thyroid disease_Homo sapiens_hsa053204.27746292
4Allograft rejection_Homo sapiens_hsa053304.22655125
5Antigen processing and presentation_Homo sapiens_hsa046123.53302376
6Type I diabetes mellitus_Homo sapiens_hsa049403.40248326
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.99491008
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74630226
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63245048
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.59976373
11Asthma_Homo sapiens_hsa053102.52608919
12T cell receptor signaling pathway_Homo sapiens_hsa046602.47401621
13Hematopoietic cell lineage_Homo sapiens_hsa046402.39704168
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.32008211
15Measles_Homo sapiens_hsa051622.17625468
16Proteasome_Homo sapiens_hsa030502.13565146
17Rheumatoid arthritis_Homo sapiens_hsa053231.98706982
18Viral myocarditis_Homo sapiens_hsa054161.80492037
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.74753239
20Leishmaniasis_Homo sapiens_hsa051401.66891850
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66561134
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60337756
23Staphylococcus aureus infection_Homo sapiens_hsa051501.55722256
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43816585
25Herpes simplex infection_Homo sapiens_hsa051681.35784152
26Osteoclast differentiation_Homo sapiens_hsa043801.34608407
27B cell receptor signaling pathway_Homo sapiens_hsa046621.23824809
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21640811
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.17880679
30Chemokine signaling pathway_Homo sapiens_hsa040621.17162277
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16188307
32Influenza A_Homo sapiens_hsa051641.09086346
33Malaria_Homo sapiens_hsa051441.03950456
34TNF signaling pathway_Homo sapiens_hsa046681.00495073
35Salmonella infection_Homo sapiens_hsa051320.97648990
36Tuberculosis_Homo sapiens_hsa051520.96560520
37African trypanosomiasis_Homo sapiens_hsa051430.89760754
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89620645
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87649600
40Toxoplasmosis_Homo sapiens_hsa051450.84826916
41Epstein-Barr virus infection_Homo sapiens_hsa051690.84227594
42Shigellosis_Homo sapiens_hsa051310.83695954
43Systemic lupus erythematosus_Homo sapiens_hsa053220.83142612
44Apoptosis_Homo sapiens_hsa042100.82572470
45Legionellosis_Homo sapiens_hsa051340.71220992
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63610839
47Caffeine metabolism_Homo sapiens_hsa002320.61565820
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60973785
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59466563
50HTLV-I infection_Homo sapiens_hsa051660.57709976
51Protein export_Homo sapiens_hsa030600.57125759
52RNA polymerase_Homo sapiens_hsa030200.53338834
53Linoleic acid metabolism_Homo sapiens_hsa005910.52175556
54Pertussis_Homo sapiens_hsa051330.51309639
55Oxidative phosphorylation_Homo sapiens_hsa001900.50964504
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50465893
57Hepatitis B_Homo sapiens_hsa051610.49404805
58Phototransduction_Homo sapiens_hsa047440.47399292
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45919360
60Parkinsons disease_Homo sapiens_hsa050120.42732424
61Viral carcinogenesis_Homo sapiens_hsa052030.36447625
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36393553
63Platelet activation_Homo sapiens_hsa046110.35880460
64Phagosome_Homo sapiens_hsa041450.34803865
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33015066
66Hepatitis C_Homo sapiens_hsa051600.32622225
67Regulation of autophagy_Homo sapiens_hsa041400.32439231
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25554992
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24764395
70RNA degradation_Homo sapiens_hsa030180.19369460
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18581622
72Ether lipid metabolism_Homo sapiens_hsa005650.18225322
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18172734
74Homologous recombination_Homo sapiens_hsa034400.16824752
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15502503
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15194059
77Alzheimers disease_Homo sapiens_hsa050100.14005461
78Peroxisome_Homo sapiens_hsa041460.13746089
79Endocytosis_Homo sapiens_hsa041440.13690115
80Nitrogen metabolism_Homo sapiens_hsa009100.12937449
81ABC transporters_Homo sapiens_hsa020100.11723951
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.10277120
83MAPK signaling pathway_Homo sapiens_hsa040100.10133736
84Acute myeloid leukemia_Homo sapiens_hsa052210.08234126
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.08224122
86Lysosome_Homo sapiens_hsa041420.07878007
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07517935
88Collecting duct acid secretion_Homo sapiens_hsa049660.07301494
89Olfactory transduction_Homo sapiens_hsa047400.05987450
90Arachidonic acid metabolism_Homo sapiens_hsa005900.05956389
91Sulfur metabolism_Homo sapiens_hsa009200.05594930
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05022205
93Pyrimidine metabolism_Homo sapiens_hsa002400.03778374
94VEGF signaling pathway_Homo sapiens_hsa043700.03772598
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.02196230
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.01800546
97Non-small cell lung cancer_Homo sapiens_hsa05223-0.0470053
98p53 signaling pathway_Homo sapiens_hsa04115-0.0384162
99Prion diseases_Homo sapiens_hsa05020-0.0277393
100Prolactin signaling pathway_Homo sapiens_hsa04917-0.0072556

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