APOBEC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.78698265
2spermatid development (GO:0007286)9.28006689
3motile cilium assembly (GO:0044458)9.24604545
4regulation of cilium movement (GO:0003352)8.64746196
5cilium movement (GO:0003341)8.24413404
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.66405402
7single fertilization (GO:0007338)7.63931462
8male meiosis (GO:0007140)7.50783150
9sperm capacitation (GO:0048240)7.39738319
10left/right axis specification (GO:0070986)7.25533117
11primary alcohol catabolic process (GO:0034310)6.96650935
12piRNA metabolic process (GO:0034587)6.90830482
13synaptonemal complex organization (GO:0070193)6.90507130
14synaptonemal complex assembly (GO:0007130)6.74346536
15microtubule bundle formation (GO:0001578)6.73080219
16vitamin transmembrane transport (GO:0035461)6.43064506
17fertilization (GO:0009566)6.27116339
18spermatogenesis (GO:0007283)6.23350062
19negative regulation of inclusion body assembly (GO:0090084)6.22521394
20male gamete generation (GO:0048232)6.21097232
21organic cation transport (GO:0015695)5.90939497
22ethanol metabolic process (GO:0006067)5.87622729
23microtubule depolymerization (GO:0007019)5.79730046
24diterpenoid biosynthetic process (GO:0016102)5.72760110
25gamete generation (GO:0007276)5.70815431
26calcium ion-dependent exocytosis (GO:0017156)5.67155469
27ventricular system development (GO:0021591)5.29649888
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.22355022
29spermatid nucleus differentiation (GO:0007289)5.20514063
30regulation of inclusion body assembly (GO:0090083)5.20479473
31regulation of microtubule-based movement (GO:0060632)5.12606715
32cell recognition (GO:0008037)5.08002118
33germ cell development (GO:0007281)5.07282072
34pyrimidine-containing compound transmembrane transport (GO:0072531)5.02771532
35regulation of interleukin-5 production (GO:0032674)5.01115205
36one-carbon compound transport (GO:0019755)4.94896003
37response to xenobiotic stimulus (GO:0009410)4.90410885
38microtubule severing (GO:0051013)4.77784557
39glycerol ether metabolic process (GO:0006662)4.73599424
40male meiosis I (GO:0007141)4.63891388
41tolerance induction (GO:0002507)4.58994797
42chromosome organization involved in meiosis (GO:0070192)4.57738999
43regulation of interleukin-13 production (GO:0032656)4.51819037
44multicellular organismal reproductive process (GO:0048609)4.49369814
45lung epithelium development (GO:0060428)4.49050430
46DNA methylation involved in gamete generation (GO:0043046)4.44409375
47ethanol oxidation (GO:0006069)4.38053694
48ether metabolic process (GO:0018904)4.36475262
49glomerular epithelial cell development (GO:0072310)4.35336112
50establishment of apical/basal cell polarity (GO:0035089)4.33188406
51cell projection assembly (GO:0030031)4.29765637
52negative regulation of immunoglobulin mediated immune response (GO:0002890)4.26230112
53negative regulation of B cell mediated immunity (GO:0002713)4.26230112
54meiotic nuclear division (GO:0007126)4.24812986
55negative regulation of humoral immune response (GO:0002921)4.21145627
56negative regulation of T cell differentiation in thymus (GO:0033085)4.19468959
57seminiferous tubule development (GO:0072520)4.10053234
58regulation of germinal center formation (GO:0002634)4.09639770
59negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.98426099
60protein polyglutamylation (GO:0018095)3.91392282
61retinal rod cell development (GO:0046548)3.88710291
62terpenoid biosynthetic process (GO:0016114)3.87388164
63left/right pattern formation (GO:0060972)3.86534353
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.84497206
65establishment of monopolar cell polarity (GO:0061162)3.84497206
66retinoic acid metabolic process (GO:0042573)3.83991633
67cytoplasmic microtubule organization (GO:0031122)3.81867794
68monoubiquitinated protein deubiquitination (GO:0035520)3.81679287
69single strand break repair (GO:0000012)3.76791430
70chromosome condensation (GO:0030261)3.76352585
71lateral ventricle development (GO:0021670)3.73272525
72positive regulation of tolerance induction (GO:0002645)3.72814236
73meiosis I (GO:0007127)3.68408031
74DNA packaging (GO:0006323)3.62560732
75genitalia morphogenesis (GO:0035112)3.61917109
76multicellular organismal development (GO:0007275)3.60248821
77protein localization to cilium (GO:0061512)3.51354607
78sexual reproduction (GO:0019953)3.51021442
79chaperone-mediated protein complex assembly (GO:0051131)3.50621790
80exogenous drug catabolic process (GO:0042738)3.48604559
81protein K11-linked deubiquitination (GO:0035871)3.43352964
82O-glycan processing (GO:0016266)3.37591554
83lactate metabolic process (GO:0006089)3.22069371
84intraciliary transport (GO:0042073)3.19957430
85retinol metabolic process (GO:0042572)3.15343978
86establishment of tissue polarity (GO:0007164)3.14670759
87establishment of planar polarity (GO:0001736)3.14670759
88primary alcohol metabolic process (GO:0034308)3.14368040
89polyol catabolic process (GO:0046174)3.14186103
90cilium organization (GO:0044782)3.08310022
91glutathione derivative metabolic process (GO:1901685)3.08150087
92glutathione derivative biosynthetic process (GO:1901687)3.08150087
93regulation of spindle checkpoint (GO:0090231)3.07276382
94axoneme assembly (GO:0035082)3.04388257
95meiotic cell cycle (GO:0051321)3.04175851
96determination of left/right symmetry (GO:0007368)3.01534344
97nucleoside diphosphate phosphorylation (GO:0006165)3.00467724
98cilium morphogenesis (GO:0060271)2.99087553
99microtubule-based movement (GO:0007018)2.97974110
100positive regulation of smoothened signaling pathway (GO:0045880)2.97697510
101cilium assembly (GO:0042384)2.97671126
102microtubule polymerization or depolymerization (GO:0031109)2.97215605
103retinal cone cell development (GO:0046549)2.97139651
104regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.96168240
105protein refolding (GO:0042026)2.96099204
106centriole assembly (GO:0098534)2.94749502
107cellular component assembly involved in morphogenesis (GO:0010927)2.92517045
108microtubule-based process (GO:0007017)2.92379485
109amino-acid betaine transport (GO:0015838)2.91558181
110carnitine transport (GO:0015879)2.91558181
111determination of bilateral symmetry (GO:0009855)2.89305393
112regulation of microtubule depolymerization (GO:0031114)2.84084787
113glycolytic process (GO:0006096)2.82887647
114sequestering of actin monomers (GO:0042989)2.82490604
115synapsis (GO:0007129)2.82364505
116specification of symmetry (GO:0009799)2.82140011
117carnitine transmembrane transport (GO:1902603)2.79792443
118carnitine metabolic process (GO:0009437)2.78590042
119nucleus organization (GO:0006997)2.78505152
120alditol metabolic process (GO:0019400)2.77831752
121multicellular organismal water homeostasis (GO:0050891)2.75816333
122calcium ion import (GO:0070509)2.75757862
123hydrogen peroxide biosynthetic process (GO:0050665)2.75536600
124aldehyde catabolic process (GO:0046185)2.73902643
125phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.73450696
126smoothened signaling pathway (GO:0007224)2.73405471
127peptidyl-glutamic acid modification (GO:0018200)2.72871107
128regulation of tolerance induction (GO:0002643)2.72257648
129drug catabolic process (GO:0042737)2.71200026
130organelle assembly (GO:0070925)2.71182990
131positive regulation of macrophage activation (GO:0043032)2.69905424
132negative regulation of organelle assembly (GO:1902116)2.68946502
133photoreceptor cell maintenance (GO:0045494)2.65385287
134apical protein localization (GO:0045176)2.63796318
135centriole replication (GO:0007099)2.63532581
136excretion (GO:0007588)2.62246839
137meiotic cell cycle process (GO:1903046)2.60830266
138GTP biosynthetic process (GO:0006183)2.60729367
139gene silencing by RNA (GO:0031047)2.57773711
140lateral sprouting from an epithelium (GO:0060601)2.57718794
141RNA localization (GO:0006403)2.56274279
142oligosaccharide biosynthetic process (GO:0009312)2.55420138
143progesterone metabolic process (GO:0042448)2.51009462
144iron ion import (GO:0097286)2.50133785
145regulation of autophagic vacuole assembly (GO:2000785)2.49524954
146cell redox homeostasis (GO:0045454)2.48709771
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.48517607
148protein O-linked glycosylation (GO:0006493)2.45658761
149phosphatidylcholine biosynthetic process (GO:0006656)2.45620749
150calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.44561740
151regulation of cilium assembly (GO:1902017)2.43647259
152reactive oxygen species biosynthetic process (GO:1903409)2.43043270
153glycerol metabolic process (GO:0006071)2.39243583
154phosphatidylethanolamine biosynthetic process (GO:0006646)2.38700543
155heart looping (GO:0001947)2.38585020
156single-organism membrane fusion (GO:0044801)2.38089170
157mitotic sister chromatid cohesion (GO:0007064)2.36065406
158sodium ion homeostasis (GO:0055078)2.33598807
159water homeostasis (GO:0030104)2.33480868
160CDP-diacylglycerol biosynthetic process (GO:0016024)2.32913715
161fusion of sperm to egg plasma membrane (GO:0007342)14.1113732
162cell wall macromolecule catabolic process (GO:0016998)13.7824112
163cell wall macromolecule metabolic process (GO:0044036)13.7824112
164sperm motility (GO:0030317)13.3708553
165acrosome assembly (GO:0001675)12.1920641
166multicellular organism reproduction (GO:0032504)11.8791404
167sperm-egg recognition (GO:0035036)11.8210795
168acrosome reaction (GO:0007340)11.4211627
169cilium or flagellum-dependent cell motility (GO:0001539)11.1533662
170plasma membrane fusion (GO:0045026)10.7624977
171cell-cell recognition (GO:0009988)10.5625769
172binding of sperm to zona pellucida (GO:0007339)10.3602541
173axonemal dynein complex assembly (GO:0070286)10.2577517
174reproduction (GO:0000003)10.0193791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.80551325
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.86894965
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.82351517
4EZH2_22144423_ChIP-Seq_EOC_Human3.95477483
5DROSHA_22980978_ChIP-Seq_HELA_Human3.38150859
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.37069542
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.13657602
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91517698
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86815798
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.81339531
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.43345303
12VDR_22108803_ChIP-Seq_LS180_Human2.40534462
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23830338
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.22691941
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18657482
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.17960047
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17328117
18AHR_22903824_ChIP-Seq_MCF-7_Human2.13571277
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10689364
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09227149
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.07354157
22KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.98370716
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96050257
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95353258
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93757940
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.93267300
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.90288718
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.83697514
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.81796842
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80874484
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.80312987
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.75162097
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75076749
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74913192
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.74269928
36TP63_23658742_ChIP-Seq_EP156T_Human1.74001504
37TP53_18474530_ChIP-ChIP_U2OS_Human1.68519409
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.68483920
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.66171620
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63708725
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61244789
42ZNF274_21170338_ChIP-Seq_K562_Hela1.61210978
43SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60133823
44MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59684667
45* STAT1_17558387_ChIP-Seq_HELA_Human1.59445326
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59258144
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.57640931
48AR_21572438_ChIP-Seq_LNCaP_Human1.57020163
49FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56297968
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54779776
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53818831
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.52792806
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.52290281
54* KDM2B_26808549_Chip-Seq_REH_Human1.51974826
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51834285
56* RUNX1_27514584_Chip-Seq_MCF-7_Human1.50686356
57CBP_20019798_ChIP-Seq_JUKART_Human1.50297045
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50297045
59* ETV1_20927104_ChIP-Seq_GIST48_Human1.48669354
60KLF5_25053715_ChIP-Seq_YYC3_Human1.48641730
61GATA3_21867929_ChIP-Seq_CD8_Mouse1.47846875
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45604358
63SMC4_20622854_ChIP-Seq_HELA_Human1.44219567
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43421089
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43340143
66SMRT_27268052_Chip-Seq_Bcells_Human1.42946831
67* NFE2_27457419_Chip-Seq_LIVER_Mouse1.42136565
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41626286
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.41443108
70* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.40116812
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39856623
72* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.39761706
73SMAD4_21799915_ChIP-Seq_A2780_Human1.38668391
74REST_21632747_ChIP-Seq_MESCs_Mouse1.37386089
75* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35621272
76* FOXA1_25552417_ChIP-Seq_VCAP_Human1.35426109
77* NANOG_18555785_Chip-Seq_ESCs_Mouse1.33930814
78* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32974864
79* PHF8_20622853_ChIP-Seq_HELA_Human1.32406222
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32301468
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.32263431
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.30845942
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30504869
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29491547
85* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29260874
86TP63_22573176_ChIP-Seq_HFKS_Human1.29236043
87GATA3_21867929_ChIP-Seq_TH1_Mouse1.29191953
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28700116
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27144645
90SOX2_20726797_ChIP-Seq_SW620_Human1.27072003
91GF1_26923725_Chip-Seq_HPCs_Mouse1.25476718
92* HNFA_21074721_ChIP-Seq_CACO-2_Human1.25270777
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24914632
94* STAT1_20625510_ChIP-Seq_HELA_Human1.23864775
95* RBPJ_21746931_ChIP-Seq_IB4_Human1.22367230
96* CRX_20693478_ChIP-Seq_RETINA_Mouse1.21969777
97TP53_16413492_ChIP-PET_HCT116_Human1.21624072
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.21010718
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20646712
100* P53_22387025_ChIP-Seq_ESCs_Mouse1.20545917
101* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19818070
102P53_21459846_ChIP-Seq_SAOS-2_Human1.19542589
103* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19277963
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18465121
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18110536
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18110536
107* OCT4_18555785_Chip-Seq_ESCs_Mouse1.18060994
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17317505
109* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17013697
110RNF2_27304074_Chip-Seq_NSC_Mouse1.16624455
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16227543
112SMAD3_21741376_ChIP-Seq_HESCs_Human1.16088518
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15457170
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15428168
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15086433
116SPI1_26923725_Chip-Seq_HPCs_Mouse1.14177060
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13960485
118* KLF4_18555785_Chip-Seq_ESCs_Mouse1.13350623
119GATA4_25053715_ChIP-Seq_YYC3_Human1.12893414
120* P300_18555785_Chip-Seq_ESCs_Mouse1.12058737
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11950015
122* NFYA_21822215_ChIP-Seq_K562_Human1.11655444
123* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11487385
124* NFYB_21822215_ChIP-Seq_K562_Human1.11122135
125STAT3_23295773_ChIP-Seq_U87_Human1.11083930
126BCAT_22108803_ChIP-Seq_LS180_Human1.10596043
127SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10577270
128* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10459096
129TAF15_26573619_Chip-Seq_HEK293_Human1.09628767
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09370585
131* TBL1_22424771_ChIP-Seq_293T_Human1.08442817
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08376082
133* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07939241
134FOXO3_23340844_ChIP-Seq_DLD1_Human1.07898231
135CEBPB_22108803_ChIP-Seq_LS180_Human1.07608634
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07491900
137* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07108586
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07055243
139* STAT3_18555785_Chip-Seq_ESCs_Mouse1.06555498
140* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05942522
141GATA1_19941826_ChIP-Seq_K562_Human1.04479940
142ERG_20517297_ChIP-Seq_VCAP_Human1.03990515
143* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03951832
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03417441
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02788409
146FOXA2_19822575_ChIP-Seq_HepG2_Human1.02658750
147* GATA6_21074721_ChIP-Seq_CACO-2_Human1.02644450
148* SOX2_18555785_Chip-Seq_ESCs_Mouse1.02607191
149* SMAD3_21741376_ChIP-Seq_EPCs_Human1.01938396
150* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01543073
151TCF4_22108803_ChIP-Seq_LS180_Human1.01535173
152* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01481473
153GF1B_26923725_Chip-Seq_HPCs_Mouse1.01272443
154* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00959533
155ELF1_20517297_ChIP-Seq_JURKAT_Human1.00934031
156CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99788775
157PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99083882
158MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98827299
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98765135
160* SMAD4_21741376_ChIP-Seq_EPCs_Human0.98687057
161ESET_19884257_ChIP-Seq_ESCs_Mouse0.98431616
162* CTCF_18555785_Chip-Seq_ESCs_Mouse0.97852926
163* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97322704
164CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97268125
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.97207350
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96948948
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.96894325
168TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95581328
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.94637592
170TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93728804
171* PU1_27457419_Chip-Seq_LIVER_Mouse0.92721471
172FOXA1_25329375_ChIP-Seq_VCAP_Human0.92220989
173FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92220989
174* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92143222
175PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91850419
176VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91505950
177PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91303128
178* E2F1_18555785_Chip-Seq_ESCs_Mouse0.91166470
179CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91135058
180RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91093456
181CTCF_27219007_Chip-Seq_Bcells_Human0.91047990
182MYC_27129775_Chip-Seq_CORNEA_Mouse0.91011928
183GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90719454
184YY1_22570637_ChIP-Seq_MALME-3M_Human0.90577048
185CTCF_20526341_ChIP-Seq_ESCs_Human0.90167222
186SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89644628
187* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89149673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.99227850
2MP0003698_abnormal_male_reproductive5.92312972
3MP0002132_abnormal_respiratory_system5.43213109
4MP0001929_abnormal_gametogenesis5.36465372
5MP0008877_abnormal_DNA_methylation4.35965679
6MP0002277_abnormal_respiratory_mucosa3.73863298
7MP0002653_abnormal_ependyma_morphology3.63875096
8MP0004133_heterotaxia3.38781036
9MP0002210_abnormal_sex_determination3.33190465
10MP0002161_abnormal_fertility/fecundity3.22957178
11MP0008789_abnormal_olfactory_epithelium3.08857622
12MP0001145_abnormal_male_reproductive2.84084613
13MP0000653_abnormal_sex_gland2.48421453
14MP0000566_synostosis2.40892515
15MP0005670_abnormal_white_adipose2.19023042
16MP0000383_abnormal_hair_follicle2.18802365
17MP0002168_other_aberrant_phenotype2.13855191
18MP0005083_abnormal_biliary_tract2.03244122
19MP0005410_abnormal_fertilization15.6901252
20MP0010678_abnormal_skin_adnexa1.99408652
21MP0005394_taste/olfaction_phenotype1.97764234
22MP0005499_abnormal_olfactory_system1.97764234
23MP0003656_abnormal_erythrocyte_physiolo1.88406283
24MP0003646_muscle_fatigue1.86040869
25MP0002282_abnormal_trachea_morphology1.85124200
26MP0001346_abnormal_lacrimal_gland1.79324939
27MP0005623_abnormal_meninges_morphology1.65220194
28MP0004233_abnormal_muscle_weight1.58444824
29MP0002160_abnormal_reproductive_system1.52252142
30MP0005395_other_phenotype1.49121159
31MP0010234_abnormal_vibrissa_follicle1.48415138
32MP0005248_abnormal_Harderian_gland1.48259205
33MP0009046_muscle_twitch1.34618172
34MP0001765_abnormal_ion_homeostasis1.32170245
35MP0005165_increased_susceptibility_to1.26965942
36MP0002734_abnormal_mechanical_nocicepti1.20025995
37MP0001984_abnormal_olfaction1.14489504
38MP0002234_abnormal_pharynx_morphology1.10575330
39MP0003183_abnormal_peptide_metabolism1.04660190
40MP0000465_gastrointestinal_hemorrhage1.03190829
41MP0002249_abnormal_larynx_morphology1.03095641
42MP0010155_abnormal_intestine_physiology1.02739349
43MP0002638_abnormal_pupillary_reflex1.02677548
44MP0002876_abnormal_thyroid_physiology1.00482394
45MP0008058_abnormal_DNA_repair0.98335701
46MP0002233_abnormal_nose_morphology0.96380594
47MP0009643_abnormal_urine_homeostasis0.95178406
48MP0005310_abnormal_salivary_gland0.94892628
49MP0004264_abnormal_extraembryonic_tissu0.91226411
50MP0000681_abnormal_thyroid_gland0.90873301
51MP0002735_abnormal_chemical_nociception0.90353015
52MP0001485_abnormal_pinna_reflex0.89799459
53MP0005220_abnormal_exocrine_pancreas0.89381848
54MP0002136_abnormal_kidney_physiology0.87582228
55MP0002693_abnormal_pancreas_physiology0.87440881
56MP0005164_abnormal_response_to0.84608388
57MP0005551_abnormal_eye_electrophysiolog0.80653236
58MP0005647_abnormal_sex_gland0.79966501
59MP0005389_reproductive_system_phenotype0.79305122
60MP0005253_abnormal_eye_physiology0.79047531
61MP0008995_early_reproductive_senescence0.78609932
62MP0005408_hypopigmentation0.77374889
63MP0004043_abnormal_pH_regulation0.77269372
64MP0005636_abnormal_mineral_homeostasis0.76948463
65MP0010030_abnormal_orbit_morphology0.74364352
66MP0002102_abnormal_ear_morphology0.72801529
67MP0000013_abnormal_adipose_tissue0.70355783
68MP0001944_abnormal_pancreas_morphology0.67716128
69MP0006072_abnormal_retinal_apoptosis0.66976879
70MP0002909_abnormal_adrenal_gland0.66408024
71MP0005085_abnormal_gallbladder_physiolo0.66378862
72MP0001324_abnormal_eye_pigmentation0.66378308
73MP0003011_delayed_dark_adaptation0.65751249
74MP0001764_abnormal_homeostasis0.65169249
75MP0002928_abnormal_bile_duct0.64199440
76MP0004883_abnormal_blood_vessel0.63201706
77MP0001502_abnormal_circadian_rhythm0.62952054
78MP0003303_peritoneal_inflammation0.62032520
79MP0009780_abnormal_chondrocyte_physiolo0.61397520
80MP0009765_abnormal_xenobiotic_induced0.60261011
81MP0001879_abnormal_lymphatic_vessel0.59966274
82MP0003890_abnormal_embryonic-extraembry0.59419027
83MP0000026_abnormal_inner_ear0.57216016
84MP0002405_respiratory_system_inflammati0.56575397
85MP0002098_abnormal_vibrissa_morphology0.55713517
86MP0003195_calcinosis0.55552291
87MP0001299_abnormal_eye_distance/0.53601194
88MP0002822_catalepsy0.53252366
89MP0003787_abnormal_imprinting0.53195337
90MP0003718_maternal_effect0.50988850
91MP0005388_respiratory_system_phenotype0.49278557
92MP0002133_abnormal_respiratory_system0.49278557
93MP0004036_abnormal_muscle_relaxation0.48711191
94MP0005503_abnormal_tendon_morphology0.48285105
95MP0001666_abnormal_nutrient_absorption0.48239075
96MP0003699_abnormal_female_reproductive0.48139770
97MP0005645_abnormal_hypothalamus_physiol0.48087368
98MP0003866_abnormal_defecation0.47863446
99MP0005646_abnormal_pituitary_gland0.47612540
100MP0003252_abnormal_bile_duct0.47284740
101MP0003075_altered_response_to0.47227596
102MP0009763_increased_sensitivity_to0.47004675
103MP0009703_decreased_birth_body0.46822288
104MP0001664_abnormal_digestion0.45813411
105MP0003878_abnormal_ear_physiology0.45799877
106MP0005377_hearing/vestibular/ear_phenot0.45799877
107MP0001849_ear_inflammation0.45402500
108MP0000467_abnormal_esophagus_morphology0.44555285
109MP0003950_abnormal_plasma_membrane0.44511595
110MP0000358_abnormal_cell_content/0.43878123
111MP0002135_abnormal_kidney_morphology0.43359723
112MP0003329_amyloid_beta_deposits0.42919561
113MP0002116_abnormal_craniofacial_bone0.42792469
114MP0001970_abnormal_pain_threshold0.42485863
115MP0003879_abnormal_hair_cell0.42132227
116MP0003633_abnormal_nervous_system0.40624146
117MP0005391_vision/eye_phenotype0.39171991
118MP0001270_distended_abdomen0.38525195
119MP0002139_abnormal_hepatobiliary_system0.36935419
120MP0003115_abnormal_respiratory_system0.36854842
121MP0003786_premature_aging0.36097220
122MP0000678_abnormal_parathyroid_gland0.35614973
123MP0004742_abnormal_vestibular_system0.33665463
124MP0000534_abnormal_ureter_morphology0.33445821
125MP0005379_endocrine/exocrine_gland_phen0.33380036
126MP0009250_abnormal_appendicular_skeleto0.33016973
127MP0005257_abnormal_intraocular_pressure0.30675721
128MP0004811_abnormal_neuron_physiology0.30428593
129MP0002736_abnormal_nociception_after0.30373429
130MP0001119_abnormal_female_reproductive0.30353324
131MP0004019_abnormal_vitamin_homeostasis0.30211080
132MP0000462_abnormal_digestive_system0.30168219
133MP0003959_abnormal_lean_body0.29825540
134MP0002078_abnormal_glucose_homeostasis0.29747441
135MP0010094_abnormal_chromosome_stability0.28982981
136MP0003953_abnormal_hormone_level0.28946707
137MP0008961_abnormal_basal_metabolism0.28702738
138MP0004270_analgesia0.28612573
139MP0000631_abnormal_neuroendocrine_gland0.26809989
140MP0002971_abnormal_brown_adipose0.26589822
141MP0002229_neurodegeneration0.26502683
142MP0001293_anophthalmia0.26091990
143MP0002269_muscular_atrophy0.24387140
144MP0005195_abnormal_posterior_eye0.24102515
145MP0002837_dystrophic_cardiac_calcinosis0.23756648
146MP0005365_abnormal_bile_salt0.23335676
147MP0003631_nervous_system_phenotype0.22844140
148MP0009115_abnormal_fat_cell0.22767827
149MP0009278_abnormal_bone_marrow0.21055047
150MP0001963_abnormal_hearing_physiology0.20906103
151MP0002572_abnormal_emotion/affect_behav0.20608242
152MP0002115_abnormal_skeleton_extremities0.19900415
153MP0005397_hematopoietic_system_phenotyp0.19841715
154MP0001545_abnormal_hematopoietic_system0.19841715
155MP0000569_abnormal_digit_pigmentation0.19740306
156MP0010386_abnormal_urinary_bladder0.19645824
157MP0006036_abnormal_mitochondrial_physio0.19507568
158MP0002152_abnormal_brain_morphology0.18775975
159MP0001968_abnormal_touch/_nociception0.18609924
160MP0004134_abnormal_chest_morphology0.18461112
161MP0003861_abnormal_nervous_system0.18418732
162MP0005666_abnormal_adipose_tissue0.17435193
163MP0002169_no_abnormal_phenotype0.17359995
164MP0009697_abnormal_copulation0.17321032

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.20979666
2Abnormal respiratory motile cilium morphology (HP:0005938)8.72009853
3Abnormal respiratory epithelium morphology (HP:0012253)8.72009853
4Rhinitis (HP:0012384)7.67314675
5Abnormal ciliary motility (HP:0012262)7.55118573
6Chronic bronchitis (HP:0004469)7.13019084
7Infertility (HP:0000789)6.13903955
8Nasal polyposis (HP:0100582)6.06239095
9Abnormality of the nasal mucosa (HP:0000433)4.91942070
10Bronchitis (HP:0012387)4.56047652
11Bronchiectasis (HP:0002110)4.55713762
12Male infertility (HP:0003251)4.30439324
13Nephronophthisis (HP:0000090)4.10911908
14Occipital encephalocele (HP:0002085)3.46778543
15Recurrent otitis media (HP:0000403)3.39128855
16Abnormal spermatogenesis (HP:0008669)3.37590727
17Recurrent sinusitis (HP:0011108)3.26159374
18Abnormality of the renal medulla (HP:0100957)3.09150755
19Hyperactive renin-angiotensin system (HP:0000841)3.06555639
20Medial flaring of the eyebrow (HP:0010747)3.05794568
21Molar tooth sign on MRI (HP:0002419)2.98289880
22Abnormality of midbrain morphology (HP:0002418)2.98289880
23Chronic otitis media (HP:0000389)2.91987780
24Recurrent bronchitis (HP:0002837)2.84733364
25Atelectasis (HP:0100750)2.83414754
26Tubulointerstitial nephritis (HP:0001970)2.67467786
27Tubular atrophy (HP:0000092)2.54167712
28Tubulointerstitial abnormality (HP:0001969)2.25662294
29Impulsivity (HP:0100710)2.24732656
30Azoospermia (HP:0000027)2.17436026
31Decreased central vision (HP:0007663)2.16721429
32Fibular hypoplasia (HP:0003038)2.10422382
33Pancreatic fibrosis (HP:0100732)2.02541236
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1012959
35Absent/shortened dynein arms (HP:0200106)12.5735517
36Dynein arm defect of respiratory motile cilia (HP:0012255)12.5735517
37Congenital primary aphakia (HP:0007707)1.97665228
38Gait imbalance (HP:0002141)1.97389178
39Decreased circulating renin level (HP:0003351)1.95166515
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94188039
41Absent epiphyses (HP:0010577)1.94188039
42Dyschromatopsia (HP:0007641)1.93693475
43Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92490271
44Cholecystitis (HP:0001082)1.87782599
45Abnormal gallbladder physiology (HP:0012438)1.87782599
46Postaxial foot polydactyly (HP:0001830)1.87601196
47Congenital hepatic fibrosis (HP:0002612)1.87596742
48Hyperkalemia (HP:0002153)1.87410639
49Renal salt wasting (HP:0000127)1.85806754
50Polydipsia (HP:0001959)1.85778020
51Abnormal drinking behavior (HP:0030082)1.85778020
52Anencephaly (HP:0002323)1.84749038
53Short femoral neck (HP:0100864)1.83729511
54Male pseudohermaphroditism (HP:0000037)1.81471834
55Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81213967
56Abnormality of the renal cortex (HP:0011035)1.79265278
57Gonadotropin excess (HP:0000837)1.78913952
58Tubulointerstitial fibrosis (HP:0005576)1.78591950
59Short ribs (HP:0000773)1.77449190
60Aplasia/Hypoplasia of the lens (HP:0008063)1.76728604
61Chronic sinusitis (HP:0011109)1.70666400
62Nephrogenic diabetes insipidus (HP:0009806)1.69797407
63Postaxial hand polydactyly (HP:0001162)1.67557945
64True hermaphroditism (HP:0010459)1.66797987
65Abnormality of renal excretion (HP:0011036)1.66116328
66Absent frontal sinuses (HP:0002688)1.65722509
67Stage 5 chronic kidney disease (HP:0003774)1.64178140
68Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.61379266
69Cystic liver disease (HP:0006706)1.59436541
70Facial cleft (HP:0002006)1.57529886
71Renal dysplasia (HP:0000110)1.56218392
72Furrowed tongue (HP:0000221)1.55865019
73Hyperaldosteronism (HP:0000859)1.54312638
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.53846747
75Asplenia (HP:0001746)1.53493104
76Sclerocornea (HP:0000647)1.53237711
77Genital tract atresia (HP:0001827)1.52185002
78Oculomotor apraxia (HP:0000657)1.52074984
79Spastic tetraparesis (HP:0001285)1.50545242
80Median cleft lip (HP:0000161)1.50383069
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.49489901
82Irregular epiphyses (HP:0010582)1.48744643
83Abnormal biliary tract physiology (HP:0012439)1.48660707
84Bile duct proliferation (HP:0001408)1.48660707
85Abnormality of chloride homeostasis (HP:0011422)1.46851535
86Vaginal atresia (HP:0000148)1.46711842
87Short thorax (HP:0010306)1.45414039
88Cone-rod dystrophy (HP:0000548)1.45329052
89Epiphyseal dysplasia (HP:0002656)1.45129739
90Abnormality of permanent molar morphology (HP:0011071)1.45039992
91Abnormality of the dental root (HP:0006486)1.45039992
92Taurodontia (HP:0000679)1.45039992
93Choroideremia (HP:0001139)1.44838248
94Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.44046474
95Abnormality of renin-angiotensin system (HP:0000847)1.44006803
96Poor coordination (HP:0002370)1.42024558
97Asymmetric septal hypertrophy (HP:0001670)1.42020097
98Chronic hepatic failure (HP:0100626)1.41031315
99Abnormality of the lower motor neuron (HP:0002366)1.40830983
100Abnormality of the dental pulp (HP:0006479)1.40779300
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.40756069
102Microglossia (HP:0000171)1.40342094
103Flattened epiphyses (HP:0003071)1.39458974
104Hyperinsulinemic hypoglycemia (HP:0000825)1.38846799
105Abnormal urine output (HP:0012590)1.38188231
106Optic nerve hypoplasia (HP:0000609)1.36383894
107Bell-shaped thorax (HP:0001591)1.35351100
108Attenuation of retinal blood vessels (HP:0007843)1.35176222
109Abnormality of saccadic eye movements (HP:0000570)1.34948745
110Abnormality of molar morphology (HP:0011070)1.34507656
111Abnormality of molar (HP:0011077)1.34507656
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32568945
113J-shaped sella turcica (HP:0002680)1.32485656
114Abnormality of dentin (HP:0010299)1.31097804
115Pancreatic cysts (HP:0001737)1.30059838
116Hemiparesis (HP:0001269)1.29432752
117Bundle branch block (HP:0011710)1.29336552
118Hypokalemic alkalosis (HP:0001949)1.29182366
119Nephropathy (HP:0000112)1.29048579
120Hyponatremia (HP:0002902)1.23403441
121Abnormal rod and cone electroretinograms (HP:0008323)1.21470203
122Preaxial hand polydactyly (HP:0001177)1.20119735
123Hand muscle atrophy (HP:0009130)1.17975183
124Glucose intolerance (HP:0000833)1.15235587
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.15048539
126Bifid scrotum (HP:0000048)1.11745970
127Fetal akinesia sequence (HP:0001989)1.11391860
128Supernumerary spleens (HP:0009799)1.10556779
129Abnormality of the frontal sinuses (HP:0002687)1.08742563
130Short nail (HP:0001799)1.04575650
131Retinitis pigmentosa (HP:0000510)1.03170665
132Abnormality of macular pigmentation (HP:0008002)1.01929038
133Abnormality of the distal phalanges of the toes (HP:0010182)1.00334218
134Portal hypertension (HP:0001409)0.97871937
135Abnormality of the hepatic vasculature (HP:0006707)0.97331029
136Hip dysplasia (HP:0001385)0.95888302
137Lip pit (HP:0100267)0.94654669
138Aplasia of the musculature (HP:0100854)0.94169922
139Absent speech (HP:0001344)0.93550949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.24931311
2PDK38.24931311
3MST45.82978797
4TESK15.73601669
5PDK25.25100003
6PRKD34.72504081
7EPHA24.63583429
8ICK3.81732666
9WNK43.01737484
10PTK2B2.43959029
11MAP3K22.21683651
12MAPKAPK32.09593522
13NME12.01427545
14STK391.99405808
15MAPK151.84403733
16BCR1.73406057
17SMG11.72218656
18STK381.69375577
19PNCK1.59532271
20DYRK1B1.56647596
21NEK21.50355887
22FRK1.50119401
23ERBB31.37313328
24MAP3K31.35020858
25MAP3K71.32741081
26BRD41.28350902
27CSK1.26834109
28MST1R1.22925438
29PDK11.15036924
30TRPM71.14554884
31STK38L1.13324337
32STK101.07667968
33WNK11.04053754
34EPHB11.01480077
35LRRK20.93824349
36TLK10.89012560
37IRAK10.85778795
38PASK0.85591292
39EPHA30.84280747
40STK30.83162626
41ERBB20.77762042
42DYRK30.77216063
43PRKCI0.76926913
44INSRR0.76720263
45CHEK20.72395368
46CDK190.68569585
47PDPK10.68035423
48WNK30.65581534
49NLK0.65553275
50CCNB10.64602394
51MAP3K120.62157797
52TBK10.60444194
53MAP2K70.59340950
54ACVR1B0.56801055
55TYRO30.56025115
56PRKAA20.55948076
57PRKG20.54718794
58PLK40.54075910
59RIPK40.53751022
60SGK10.51144343
61TTK0.48091104
62CAMK1G0.46236511
63BRSK20.45542202
64CAMK2G0.44859064
65PINK10.43595033
66LMTK20.41434371
67PRKCG0.40900059
68MAP4K20.37770079
69HIPK20.37666005
70MAP2K60.37030648
71FGFR30.36211248
72CHEK10.35840720
73TYK20.35532807
74TAOK10.35108531
75MARK20.34578980
76RPS6KB20.34176474
77GRK10.34052109
78MET0.33566401
79BRAF0.33382826
80GRK60.33024438
81CDC42BPA0.31714725
82MAP3K40.31600406
83PAK10.29486957
84RPS6KB10.29448495
85PIK3CG0.29369558
86MTOR0.29085050
87SGK20.28905344
88MAP3K100.28475213
89CAMKK20.27918756
90TESK20.27754780
91ATM0.27527855
92DYRK1A0.27062629
93ADRBK10.26523144
94MARK30.24989472
95ATR0.24206439
96RPS6KA20.22845952
97MUSK0.22391906
98MAP2K40.21574494
99ABL10.21182168
100SGK4940.21068991
101SGK2230.21068991
102CDK150.20988825
103STK110.20910468
104ROCK10.20735414
105BRSK10.20655581
106STK160.19722494
107EEF2K0.19489170
108EGFR0.19386414
109NEK90.19341940
110PRKAA10.18854090
111CDK180.18619286
112MKNK20.18108409
113NEK60.17727583
114MAP2K20.17121274
115FYN0.17008179
116ERBB40.16898837
117CDK11A0.16699620
118WEE10.16506771
119CDK140.16111843
120CDC70.15289152
121CDK60.15284073
122ZAP700.14498811
123SRC0.13741897
124MYLK0.13186578
125MAP3K50.12784702
126PRKCZ0.12654234
127MAP3K10.12444909
128CDK30.12046311
129RPS6KA10.11802824
130MAPKAPK50.10154079
131AKT30.09395737
132DDR20.09194955
133IRAK20.09034506
134LATS10.08507938
135PAK20.07934419
136PRKG10.07785506
137PRKCQ0.07598010
138CSNK2A10.07156991
139PRKACG0.07064061
140GSK3B0.06909095
141STK240.06399308
142PLK10.05910614
143CAMK2A0.05747528
144CAMKK10.05731734
145CDK120.05680651
146NTRK20.05622493
147AURKA0.05030374
148ADRBK20.04732701
149FER0.04119601
150PAK40.02948341
151PRKCD0.02625499
152CLK10.02549829
153OXSR10.02223436
154CDK10.01999068
155MAPK80.01535979
156PRKACA0.00947814
157CDK20.00925753
158PRKCA0.00613217
159CSNK2A20.00512357
160PRKCB0.00194276

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.86511329
2Histidine metabolism_Homo sapiens_hsa003404.49680924
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.02556722
4Vitamin B6 metabolism_Homo sapiens_hsa007503.73402507
5Tyrosine metabolism_Homo sapiens_hsa003503.70263176
6Fatty acid biosynthesis_Homo sapiens_hsa000613.60116165
7Pyruvate metabolism_Homo sapiens_hsa006203.03973713
8beta-Alanine metabolism_Homo sapiens_hsa004102.95702273
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.88874678
10Linoleic acid metabolism_Homo sapiens_hsa005912.85885543
11Glucagon signaling pathway_Homo sapiens_hsa049222.70654344
12Basal transcription factors_Homo sapiens_hsa030222.53211796
13Retinol metabolism_Homo sapiens_hsa008302.48436812
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.46395129
15Caffeine metabolism_Homo sapiens_hsa002322.44199760
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.42626095
17Propanoate metabolism_Homo sapiens_hsa006402.41552005
18Glycosaminoglycan degradation_Homo sapiens_hsa005312.38615685
19Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38436859
20Maturity onset diabetes of the young_Homo sapiens_hsa049502.27087968
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.21777986
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21004806
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08520427
24Pentose phosphate pathway_Homo sapiens_hsa000302.08354246
25Selenocompound metabolism_Homo sapiens_hsa004501.89226076
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80591493
27Amphetamine addiction_Homo sapiens_hsa050311.70661045
28Insulin secretion_Homo sapiens_hsa049111.65518532
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.58696916
30Fructose and mannose metabolism_Homo sapiens_hsa000511.54142036
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54035284
32Mineral absorption_Homo sapiens_hsa049781.53757223
33Glycerolipid metabolism_Homo sapiens_hsa005611.53065497
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.52208952
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50305250
36Oocyte meiosis_Homo sapiens_hsa041141.46692668
37Collecting duct acid secretion_Homo sapiens_hsa049661.42499672
38Tight junction_Homo sapiens_hsa045301.42164245
39Ether lipid metabolism_Homo sapiens_hsa005651.39168244
40PPAR signaling pathway_Homo sapiens_hsa033201.36305909
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35415274
42Circadian rhythm_Homo sapiens_hsa047101.29972519
43Synaptic vesicle cycle_Homo sapiens_hsa047211.27549617
44Fanconi anemia pathway_Homo sapiens_hsa034601.26581831
45Huntingtons disease_Homo sapiens_hsa050161.25267359
46Dorso-ventral axis formation_Homo sapiens_hsa043201.18992307
47Purine metabolism_Homo sapiens_hsa002301.18559271
48Peroxisome_Homo sapiens_hsa041461.16550807
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15986878
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13375012
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12134918
52Cardiac muscle contraction_Homo sapiens_hsa042601.10336633
53Renin secretion_Homo sapiens_hsa049241.07928714
54Renin-angiotensin system_Homo sapiens_hsa046141.06214490
55Carbon metabolism_Homo sapiens_hsa012001.06155434
56Fat digestion and absorption_Homo sapiens_hsa049750.98656475
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.95273088
58Fatty acid metabolism_Homo sapiens_hsa012120.89297385
59Starch and sucrose metabolism_Homo sapiens_hsa005000.87029969
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86250885
61Fatty acid degradation_Homo sapiens_hsa000710.82591301
62mRNA surveillance pathway_Homo sapiens_hsa030150.82262503
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79964770
64Legionellosis_Homo sapiens_hsa051340.79857744
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.79543754
66Thyroid hormone synthesis_Homo sapiens_hsa049180.77177590
67Long-term potentiation_Homo sapiens_hsa047200.74714600
68Antigen processing and presentation_Homo sapiens_hsa046120.74217572
69Adherens junction_Homo sapiens_hsa045200.73206761
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72878559
71Estrogen signaling pathway_Homo sapiens_hsa049150.72134030
72Protein digestion and absorption_Homo sapiens_hsa049740.71753790
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.71572750
74Taste transduction_Homo sapiens_hsa047420.70275746
75Arachidonic acid metabolism_Homo sapiens_hsa005900.70060383
76Sulfur metabolism_Homo sapiens_hsa009200.69865189
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69141826
78RNA transport_Homo sapiens_hsa030130.69059710
79Hedgehog signaling pathway_Homo sapiens_hsa043400.66989106
80Glutathione metabolism_Homo sapiens_hsa004800.66857583
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66663733
82N-Glycan biosynthesis_Homo sapiens_hsa005100.64467334
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64138369
84Vibrio cholerae infection_Homo sapiens_hsa051100.62513310
85Circadian entrainment_Homo sapiens_hsa047130.62450102
86Biosynthesis of amino acids_Homo sapiens_hsa012300.62244838
87ABC transporters_Homo sapiens_hsa020100.61711550
88Hepatitis C_Homo sapiens_hsa051600.60593375
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.58707885
90Choline metabolism in cancer_Homo sapiens_hsa052310.57586934
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.57139583
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56222027
93Olfactory transduction_Homo sapiens_hsa047400.56032566
94Type II diabetes mellitus_Homo sapiens_hsa049300.55963134
95Cocaine addiction_Homo sapiens_hsa050300.55562713
96cAMP signaling pathway_Homo sapiens_hsa040240.54620569
97Calcium signaling pathway_Homo sapiens_hsa040200.53180598
98Pancreatic secretion_Homo sapiens_hsa049720.52509665
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51759995
100Inositol phosphate metabolism_Homo sapiens_hsa005620.50029314
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49641800
102Nicotine addiction_Homo sapiens_hsa050330.48734146
103Endocytosis_Homo sapiens_hsa041440.48180138
104Chemical carcinogenesis_Homo sapiens_hsa052040.48112054
105Type I diabetes mellitus_Homo sapiens_hsa049400.48081996
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47963505
107Salivary secretion_Homo sapiens_hsa049700.46521916
108Butanoate metabolism_Homo sapiens_hsa006500.46314407
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45081922
110AMPK signaling pathway_Homo sapiens_hsa041520.44249645
111Complement and coagulation cascades_Homo sapiens_hsa046100.43928452
112Bile secretion_Homo sapiens_hsa049760.43713628
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42657707
114Notch signaling pathway_Homo sapiens_hsa043300.40522397
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40455400
116Metabolic pathways_Homo sapiens_hsa011000.39754772
117Hematopoietic cell lineage_Homo sapiens_hsa046400.39664834
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38791965
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.38103910
120Systemic lupus erythematosus_Homo sapiens_hsa053220.37842257
121Phototransduction_Homo sapiens_hsa047440.36372567
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.35279354
123Salmonella infection_Homo sapiens_hsa051320.33839045
124Sphingolipid metabolism_Homo sapiens_hsa006000.32496046
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32152756
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32118889
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.30130874
128Pyrimidine metabolism_Homo sapiens_hsa002400.29563903
129Gastric acid secretion_Homo sapiens_hsa049710.29397304
130Tryptophan metabolism_Homo sapiens_hsa003800.27852273
131Serotonergic synapse_Homo sapiens_hsa047260.27819961
132Alcoholism_Homo sapiens_hsa050340.27679589
133Basal cell carcinoma_Homo sapiens_hsa052170.25348079
134Regulation of autophagy_Homo sapiens_hsa041400.24875050
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24244557
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23159969
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21923200
138Hippo signaling pathway_Homo sapiens_hsa043900.21401006
139Arginine and proline metabolism_Homo sapiens_hsa003300.21169349
140Lysosome_Homo sapiens_hsa041420.20705178
141Dopaminergic synapse_Homo sapiens_hsa047280.19411367
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19083598
143Vitamin digestion and absorption_Homo sapiens_hsa049770.18809779
144Amoebiasis_Homo sapiens_hsa051460.18329963
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.17426634
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16327623
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15595833
148Insulin resistance_Homo sapiens_hsa049310.14820651
149Rheumatoid arthritis_Homo sapiens_hsa053230.14764891
150Steroid biosynthesis_Homo sapiens_hsa001000.14371970
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13965346
152Allograft rejection_Homo sapiens_hsa053300.11179425
153Autoimmune thyroid disease_Homo sapiens_hsa053200.10801280
154Dilated cardiomyopathy_Homo sapiens_hsa054140.10555848
155Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10490515
156Ovarian steroidogenesis_Homo sapiens_hsa049130.09186666
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08722154
158Axon guidance_Homo sapiens_hsa043600.08543042
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08328785

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