APOBR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.43547844
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.43547844
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.43547844
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.43547844
5modulation by symbiont of host immune response (GO:0052553)6.43547844
6positive regulation by symbiont of host defense response (GO:0052509)6.43547844
7neutrophil activation involved in immune response (GO:0002283)5.36093840
8response to peptidoglycan (GO:0032494)5.05697427
9regulation of interferon-beta biosynthetic process (GO:0045357)4.86346668
10detection of bacterium (GO:0016045)4.76485171
11response to host immune response (GO:0052572)4.67230104
12response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.67230104
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60223139
14leukocyte aggregation (GO:0070486)4.52739570
15macrophage activation involved in immune response (GO:0002281)4.52472554
16respiratory burst (GO:0045730)4.38479085
17cellular extravasation (GO:0045123)4.38065868
18response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.33250159
19response to host (GO:0075136)4.33250159
20response to host defenses (GO:0052200)4.33250159
21positive regulation of interferon-alpha production (GO:0032727)4.31228443
22detection of external biotic stimulus (GO:0098581)4.25496301
23positive regulation of gamma-delta T cell activation (GO:0046645)4.19992972
24regulation of B cell receptor signaling pathway (GO:0050855)4.17256481
25negative regulation of cell killing (GO:0031342)4.16780973
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.16780973
27regulation of interferon-alpha production (GO:0032647)4.10751448
28immunoglobulin mediated immune response (GO:0016064)4.06165769
29response to muramyl dipeptide (GO:0032495)4.04363322
30neutrophil activation (GO:0042119)4.00896286
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.94401943
32leukocyte migration involved in inflammatory response (GO:0002523)3.93480120
33production of molecular mediator involved in inflammatory response (GO:0002532)3.93392549
34granulocyte activation (GO:0036230)3.93229495
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87708054
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87708054
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.83128685
38neutrophil mediated immunity (GO:0002446)3.82327224
39detection of biotic stimulus (GO:0009595)3.74669584
40positive regulation of antigen processing and presentation (GO:0002579)3.68154005
41negative regulation of interleukin-12 production (GO:0032695)3.61737124
42negative regulation of leukocyte mediated immunity (GO:0002704)3.58085253
43myeloid cell activation involved in immune response (GO:0002275)3.57134846
44antigen processing and presentation of endogenous antigen (GO:0019883)3.53029231
45positive regulation of mast cell activation (GO:0033005)3.51437401
46response to fungus (GO:0009620)3.49310577
47negative regulation of erythrocyte differentiation (GO:0045647)3.46151068
48regulation of mast cell degranulation (GO:0043304)3.45997669
49negative regulation of T cell mediated immunity (GO:0002710)3.44188653
50antigen processing and presentation via MHC class Ib (GO:0002475)3.38217657
51Arp2/3 complex-mediated actin nucleation (GO:0034314)3.35494961
52regulation of gamma-delta T cell differentiation (GO:0045586)3.34975125
53response to interleukin-15 (GO:0070672)3.34650439
54leukocyte cell-cell adhesion (GO:0007159)3.29660747
55regulation of leukocyte degranulation (GO:0043300)3.26285431
56microglial cell activation (GO:0001774)3.24897066
57regulation of mast cell activation involved in immune response (GO:0033006)3.24764472
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23527299
59regulation of mast cell activation (GO:0033003)3.22864458
60regulation of T cell tolerance induction (GO:0002664)3.22648342
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21536775
62defense response to protozoan (GO:0042832)3.20898605
63pinocytosis (GO:0006907)3.20132573
64regulation of tolerance induction (GO:0002643)3.17244908
65regulation of antigen processing and presentation (GO:0002577)3.16877645
66positive regulation of B cell differentiation (GO:0045579)3.15452283
67regulation of myeloid leukocyte mediated immunity (GO:0002886)3.15000303
68regulation of T-helper 2 cell differentiation (GO:0045628)3.13419813
69regulation of regulated secretory pathway (GO:1903305)3.11849399
70leukocyte degranulation (GO:0043299)3.11685716
71response to type I interferon (GO:0034340)3.11685313
72macrophage activation (GO:0042116)3.10405378
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08658937
74lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08253953
75detection of molecule of bacterial origin (GO:0032490)3.08137882
76cellular response to type I interferon (GO:0071357)3.07868607
77type I interferon signaling pathway (GO:0060337)3.07868607
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07568128
79positive regulation of interferon-beta production (GO:0032728)3.07515579
80positive regulation of mast cell degranulation (GO:0043306)3.07508229
81positive regulation of mast cell activation involved in immune response (GO:0033008)3.07508229
82cellular response to interleukin-15 (GO:0071350)3.05832043
83negative regulation of cytokine production involved in immune response (GO:0002719)3.04878969
84neutrophil chemotaxis (GO:0030593)3.04203514
85hydrogen peroxide biosynthetic process (GO:0050665)3.03859209
86leukotriene metabolic process (GO:0006691)3.02970057
87regulation of integrin activation (GO:0033623)3.02540508
88germinal center formation (GO:0002467)3.02063050
89I-kappaB phosphorylation (GO:0007252)3.00677785
90B cell mediated immunity (GO:0019724)2.99631995
91B cell receptor signaling pathway (GO:0050853)2.98655760
92response to protozoan (GO:0001562)2.98596715
93T-helper 1 type immune response (GO:0042088)2.97752103
94positive regulation of cellular amide metabolic process (GO:0034250)2.96971591
95natural killer cell mediated cytotoxicity (GO:0042267)2.96784671
96natural killer cell mediated immunity (GO:0002228)2.96784671
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.95752298
98neutrophil migration (GO:1990266)2.95045400
99leukocyte mediated cytotoxicity (GO:0001909)2.93014440
100negative regulation of innate immune response (GO:0045824)2.92245161
101interferon-gamma-mediated signaling pathway (GO:0060333)2.91439484
102myeloid leukocyte mediated immunity (GO:0002444)2.89885756
103negative regulation of interleukin-6 production (GO:0032715)2.87368533
104mannose metabolic process (GO:0006013)2.86586809
105response to interferon-alpha (GO:0035455)2.85561592
106superoxide anion generation (GO:0042554)2.84643606
107apoptotic cell clearance (GO:0043277)2.84106700
108regulation of B cell differentiation (GO:0045577)2.83768900
109negative regulation of type 2 immune response (GO:0002829)2.82367948
110positive regulation of leukocyte degranulation (GO:0043302)2.79683888
111defense response to fungus (GO:0050832)2.79131918
112regulation of gamma-delta T cell activation (GO:0046643)2.78854513
113regulation of T cell mediated cytotoxicity (GO:0001914)2.78504531
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.77870226
115dendritic cell chemotaxis (GO:0002407)2.77389834
116regulation of interleukin-8 biosynthetic process (GO:0045414)2.76411062
117positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75585391
118detection of other organism (GO:0098543)2.74953030
119positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.74536794
120positive regulation of toll-like receptor signaling pathway (GO:0034123)2.74196353
121regulation of phagocytosis (GO:0050764)2.73735314
122myeloid leukocyte activation (GO:0002274)2.72510467
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71537663
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71175232
125actin nucleation (GO:0045010)2.70371118
126reactive oxygen species biosynthetic process (GO:1903409)2.68335966
127negative regulation of granulocyte differentiation (GO:0030853)2.67307683
128negative regulation of phagocytosis (GO:0050765)2.66223044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.72157407
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.84453444
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.80281933
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.98856314
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.96095122
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.68296016
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.64582876
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.54381033
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.52115975
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33941085
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08119488
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.01787328
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99066721
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97258651
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74085722
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.69589806
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.67843813
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53289264
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52289063
20VDR_21846776_ChIP-Seq_THP-1_Human2.51940580
21SCL_19346495_ChIP-Seq_HPC-7_Human2.43054633
22* SPI1_23547873_ChIP-Seq_NB4_Human2.39688382
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24360008
24VDR_24763502_ChIP-Seq_THP-1_Human2.24209771
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24170597
26SPI1_23127762_ChIP-Seq_K562_Human2.16905693
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16103468
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.06061109
29MAF_26560356_Chip-Seq_TH1_Human2.05057437
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99131118
31E2F7_22180533_ChIP-Seq_HELA_Human1.98231581
32MYB_26560356_Chip-Seq_TH2_Human1.97152851
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93735120
34MYC_22102868_ChIP-Seq_BL_Human1.93459591
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83787879
36TCF7_22412390_ChIP-Seq_EML_Mouse1.77411885
37RUNX_20019798_ChIP-Seq_JUKART_Human1.76894638
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76179530
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76001529
40PU_27001747_Chip-Seq_BMDM_Mouse1.72787131
41MYB_26560356_Chip-Seq_TH1_Human1.72402098
42UTX_26944678_Chip-Seq_JUKART_Human1.67739036
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66391541
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63599648
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58704881
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54507282
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53915090
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51666359
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.50631181
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.47209250
51VDR_24787735_ChIP-Seq_THP-1_Human1.46771755
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46474838
53* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41537369
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39542345
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39093065
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37500403
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35340544
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33878845
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30265345
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28844806
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28815568
62KDM2B_26808549_Chip-Seq_DND41_Human1.27542574
63GATA3_27048872_Chip-Seq_THYMUS_Human1.26703401
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.26652991
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25949908
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23557436
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22771971
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21908808
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.20294683
70MAF_26560356_Chip-Seq_TH2_Human1.20190179
71BCL6_27268052_Chip-Seq_Bcells_Human1.18519801
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17463679
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16501185
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15944282
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14458025
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12862596
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12227056
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.11956860
79BCOR_27268052_Chip-Seq_Bcells_Human1.11429625
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.09836888
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08093825
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07579934
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05551877
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05292966
85TFEB_21752829_ChIP-Seq_HELA_Human1.05062393
86GATA3_26560356_Chip-Seq_TH2_Human1.04759454
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02955455
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99749087
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99601084
90LXR_22292898_ChIP-Seq_THP-1_Human0.97533642
91GATA2_19941826_ChIP-Seq_K562_Human0.96916903
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95556178
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94556060
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94083964
95GATA1_19941826_ChIP-Seq_K562_Human0.93608886
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92298958
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91516477
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90341027
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89882379
100GATA1_22025678_ChIP-Seq_K562_Human0.89656360
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89064077
102NCOR1_26117541_ChIP-Seq_K562_Human0.89059898
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.88104122
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87209536
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86561113
106SA1_27219007_Chip-Seq_ERYTHROID_Human0.85352114
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83958754
108SPI1_20517297_ChIP-Seq_HL60_Human0.81626330
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79889422
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78273774
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77318551
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74478662
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.72078980
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72078980
115RACK7_27058665_Chip-Seq_MCF-7_Human0.71979045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.02513999
2MP0003436_decreased_susceptibility_to3.90347113
3MP0005058_abnormal_lysosome_morphology3.43105319
4MP0001835_abnormal_antigen_presentation3.40809314
5MP0002419_abnormal_innate_immunity3.07343451
6MP0009785_altered_susceptibility_to2.90426596
7MP0005000_abnormal_immune_tolerance2.72143572
8MP0005025_abnormal_response_to2.66573382
9MP0006082_CNS_inflammation2.65654199
10MP0005387_immune_system_phenotype2.64830693
11MP0001790_abnormal_immune_system2.64830693
12MP0009278_abnormal_bone_marrow2.62325431
13MP0000685_abnormal_immune_system2.61959755
14MP0003172_abnormal_lysosome_physiology2.53308031
15MP0002452_abnormal_antigen_presenting2.45573629
16MP0004510_myositis2.44532333
17MP0002148_abnormal_hypersensitivity_rea2.44213427
18MP0005464_abnormal_platelet_physiology2.41663795
19MP0001800_abnormal_humoral_immune2.37219503
20MP0003724_increased_susceptibility_to2.32336314
21MP0003300_gastrointestinal_ulcer2.29575313
22MP0002723_abnormal_immune_serum2.24800491
23MP0000569_abnormal_digit_pigmentation2.24038135
24MP0001533_abnormal_skeleton_physiology2.23934225
25MP0001819_abnormal_immune_cell2.16983285
26MP0002420_abnormal_adaptive_immunity2.15730825
27MP0004947_skin_inflammation2.08505029
28MP0005671_abnormal_response_to2.08435538
29MP0003183_abnormal_peptide_metabolism2.06404440
30MP0002405_respiratory_system_inflammati1.98506116
31MP0003448_altered_tumor_morphology1.90310316
32MP0001545_abnormal_hematopoietic_system1.79662174
33MP0005397_hematopoietic_system_phenotyp1.79662174
34MP0009840_abnormal_foam_cell1.78631768
35MP0001845_abnormal_inflammatory_respons1.77531916
36MP0000343_altered_response_to1.72088059
37MP0005451_abnormal_body_composition1.69880592
38MP0003566_abnormal_cell_adhesion1.65053364
39MP0002398_abnormal_bone_marrow1.63296819
40MP0000716_abnormal_immune_system1.62528202
41MP0002132_abnormal_respiratory_system1.61326655
42MP0010307_abnormal_tumor_latency1.58122911
43MP0001853_heart_inflammation1.57080021
44MP0009333_abnormal_splenocyte_physiolog1.54318486
45MP0003075_altered_response_to1.52849127
46MP0005076_abnormal_cell_differentiation1.52587562
47MP0000465_gastrointestinal_hemorrhage1.49567105
48MP0001851_eye_inflammation1.47114089
49MP0008469_abnormal_protein_level1.46893356
50MP0000689_abnormal_spleen_morphology1.46341232
51MP0010155_abnormal_intestine_physiology1.46309805
52MP0000858_altered_metastatic_potential1.45669354
53MP0004808_abnormal_hematopoietic_stem1.43592670
54MP0002396_abnormal_hematopoietic_system1.40092782
55MP0005174_abnormal_tail_pigmentation1.39949240
56MP0002166_altered_tumor_susceptibility1.37838598
57MP0003191_abnormal_cellular_cholesterol1.36248844
58MP0002429_abnormal_blood_cell1.36088823
59MP0002722_abnormal_immune_system1.35490910
60MP0000604_amyloidosis1.33375823
61MP0003705_abnormal_hypodermis_morpholog1.29653458
62MP0002933_joint_inflammation1.26536284
63MP0002998_abnormal_bone_remodeling1.23039125
64MP0005310_abnormal_salivary_gland1.22890775
65MP0001873_stomach_inflammation1.20421887
66MP0005023_abnormal_wound_healing1.18988451
67MP0002006_tumorigenesis1.16376792
68MP0009764_decreased_sensitivity_to1.13070368
69MP0005390_skeleton_phenotype1.09047827
70MP0008004_abnormal_stomach_pH1.08980154
71MP0003806_abnormal_nucleotide_metabolis1.06935274
72MP0000490_abnormal_crypts_of1.03394752
73MP0003828_pulmonary_edema1.00787002
74MP0005166_decreased_susceptibility_to1.00039363
75MP0010352_gastrointestinal_tract_polyps0.99319246
76MP0003453_abnormal_keratinocyte_physiol0.98190677
77MP0008438_abnormal_cutaneous_collagen0.97708270
78MP0004381_abnormal_hair_follicle0.97635479
79MP0001958_emphysema0.95588013
80MP0003091_abnormal_cell_migration0.93930438
81MP0009763_increased_sensitivity_to0.92663093
82MP0008260_abnormal_autophagy0.88252394
83MP0003690_abnormal_glial_cell0.87464511
84MP0003656_abnormal_erythrocyte_physiolo0.83764041
85MP0000703_abnormal_thymus_morphology0.83481187
86MP0000249_abnormal_blood_vessel0.82679439
87MP0005164_abnormal_response_to0.82572721
88MP0002138_abnormal_hepatobiliary_system0.81479048
89MP0000015_abnormal_ear_pigmentation0.79186427
90MP0003763_abnormal_thymus_physiology0.75594287
91MP0000371_diluted_coat_color0.73660312
92MP0002877_abnormal_melanocyte_morpholog0.73065788
93MP0003795_abnormal_bone_structure0.72541970
94MP0009765_abnormal_xenobiotic_induced0.71339896
95MP0005167_abnormal_blood-brain_barrier0.70339360
96MP0002254_reproductive_system_inflammat0.69084005
97MP0000767_abnormal_smooth_muscle0.68405120
98MP0004883_abnormal_blood_vessel0.67863884
99MP0003045_fibrosis0.66790759
100MP0001663_abnormal_digestive_system0.63981195
101MP0001881_abnormal_mammary_gland0.63690573
102MP0001986_abnormal_taste_sensitivity0.63327717
103MP0005257_abnormal_intraocular_pressure0.62586589
104MP0008874_decreased_physiological_sensi0.62420449
105MP0002277_abnormal_respiratory_mucosa0.62195209
106MP0005319_abnormal_enzyme/_coenzyme0.60734326
107MP0000920_abnormal_myelination0.60648799
108MP0003279_aneurysm0.59877124
109MP0002019_abnormal_tumor_incidence0.59362224
110MP0003866_abnormal_defecation0.58898745
111MP0005621_abnormal_cell_physiology0.56085918
112MP0005381_digestive/alimentary_phenotyp0.55741045
113MP0001915_intracranial_hemorrhage0.54803472
114MP0005075_abnormal_melanosome_morpholog0.54673620
115MP0002332_abnormal_exercise_endurance0.53407453
116MP0003329_amyloid_beta_deposits0.52474420
117MP0005083_abnormal_biliary_tract0.51300156
118MP0000609_abnormal_liver_physiology0.49040153
119MP0003221_abnormal_cardiomyocyte_apopto0.47324919

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.99022991
2Eczematoid dermatitis (HP:0000976)6.71686087
3Recurrent bacterial skin infections (HP:0005406)6.24320021
4Recurrent gram-negative bacterial infections (HP:0005420)5.69225055
5Abnormality of macrophages (HP:0004311)5.18447674
6Vacuolated lymphocytes (HP:0001922)4.42988333
7Systemic lupus erythematosus (HP:0002725)4.41695263
8Increased cerebral lipofuscin (HP:0011813)4.29766279
9Myositis (HP:0100614)4.23928147
10Mediastinal lymphadenopathy (HP:0100721)4.03050807
11Obstructive lung disease (HP:0006536)3.88699743
12Chronic obstructive pulmonary disease (HP:0006510)3.88699743
13Recurrent skin infections (HP:0001581)3.86034356
14Recurrent fungal infections (HP:0002841)3.81889962
15Orchitis (HP:0100796)3.81470407
16Gingivitis (HP:0000230)3.78550821
17Gastrointestinal infarctions (HP:0005244)3.75451672
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.75137223
19Dysostosis multiplex (HP:0000943)3.65976688
20Encephalitis (HP:0002383)3.46236471
21Elevated erythrocyte sedimentation rate (HP:0003565)3.42950553
22Retrobulbar optic neuritis (HP:0100654)3.41376983
23Optic neuritis (HP:0100653)3.41376983
24Hypochromic microcytic anemia (HP:0004840)3.29507284
25Pustule (HP:0200039)3.19519798
26Stomatitis (HP:0010280)3.08682497
27Cellulitis (HP:0100658)3.06639538
28Urinary glycosaminoglycan excretion (HP:0003541)3.04698140
29Mucopolysacchariduria (HP:0008155)3.04698140
30Abnormality of glycolipid metabolism (HP:0010969)3.02395133
31Abnormality of liposaccharide metabolism (HP:0010968)3.02395133
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.02395133
33Disinhibition (HP:0000734)2.96605312
34Periodontitis (HP:0000704)2.96515955
35Hypochromic anemia (HP:0001931)2.94634957
36Amyloidosis (HP:0011034)2.92142677
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.91263558
38Abnormality of polysaccharide metabolism (HP:0011012)2.91263558
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.91263558
40Recurrent viral infections (HP:0004429)2.89586860
41Autoimmune thrombocytopenia (HP:0001973)2.89512808
42Axonal loss (HP:0003447)2.86420797
43Glomerulonephritis (HP:0000099)2.85552362
44Urticaria (HP:0001025)2.85103785
45Episodic fever (HP:0001954)2.83770435
46Spontaneous hematomas (HP:0007420)2.81654125
47Loss of speech (HP:0002371)2.76929684
48Vasculitis (HP:0002633)2.73376098
49Meningitis (HP:0001287)2.71497306
50Arterial thrombosis (HP:0004420)2.71169604
51T lymphocytopenia (HP:0005403)2.65392462
52Chronic mucocutaneous candidiasis (HP:0002728)2.64646266
53Recurrent cutaneous fungal infections (HP:0011370)2.64646266
54Interstitial pulmonary disease (HP:0006530)2.57864566
55Abnormality of T cell number (HP:0011839)2.56826660
56Osteolytic defects of the hand bones (HP:0009699)2.56047900
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.56047900
58Anorexia (HP:0002039)2.55033552
59Hematochezia (HP:0002573)2.50905290
60Increased IgM level (HP:0003496)2.50883221
61Osteomyelitis (HP:0002754)2.49488912
62Gingival bleeding (HP:0000225)2.47940149
63Purpura (HP:0000979)2.45221764
64Prolonged bleeding time (HP:0003010)2.44991571
65Chronic otitis media (HP:0000389)2.43644619
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.43258643
67Nasal polyposis (HP:0100582)2.39028239
68IgM deficiency (HP:0002850)2.36542142
69Prostate neoplasm (HP:0100787)2.35382712
70Leukocytosis (HP:0001974)2.35012419
71Increased serum ferritin (HP:0003281)2.32928818
72Microcytic anemia (HP:0001935)2.31115049
73Abnormality of T cells (HP:0002843)2.30798693
74Myocardial infarction (HP:0001658)2.30625209
75Inflammation of the large intestine (HP:0002037)2.28658917
76Granulocytopenia (HP:0001913)2.28369288
77J-shaped sella turcica (HP:0002680)2.28332184
78Abnormality of the nasal mucosa (HP:0000433)2.27250179
79Hypergammaglobulinemia (HP:0010702)2.26718547
80Thoracic kyphosis (HP:0002942)2.25832554
81Petechiae (HP:0000967)2.23888422
82Pulmonary infiltrates (HP:0002113)2.23332034
83Panhypogammaglobulinemia (HP:0003139)2.22962982
84Gangrene (HP:0100758)2.20680385
85Epistaxis (HP:0000421)2.19668380
86Abnormality of the pleura (HP:0002103)2.18755052
87Gastrointestinal inflammation (HP:0004386)2.17140440
88Basal ganglia calcification (HP:0002135)2.16687904
89Abnormality of iron homeostasis (HP:0011031)2.16613210
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15662567
91Agnosia (HP:0010524)2.15520873
92Thick nail (HP:0001805)2.15420969
93Premature loss of primary teeth (HP:0006323)2.14893636
94Nephritis (HP:0000123)2.14476897
95Sepsis (HP:0100806)2.14424945
96Keratoconjunctivitis sicca (HP:0001097)2.14031298
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.13366429
98Peritonitis (HP:0002586)2.11021127
99Increased IgE level (HP:0003212)2.10744447
100Hepatosplenomegaly (HP:0001433)2.10529229
101Lymphopenia (HP:0001888)2.09898397
102Increased density of long bones (HP:0006392)2.09459918
103Colitis (HP:0002583)2.06608441
104Menorrhagia (HP:0000132)2.06424134
105Hemoptysis (HP:0002105)2.06058209
106Abnormality of the lumbar spine (HP:0100712)2.06056007
107Abnormal platelet function (HP:0011869)2.06030814
108Impaired platelet aggregation (HP:0003540)2.06030814
109Absent frontal sinuses (HP:0002688)2.04524517
110Glomerulopathy (HP:0100820)2.04346809
111Acne (HP:0001061)2.00589593
112Abnormality of T cell physiology (HP:0011840)1.99033517
113Abnormality of the endocardium (HP:0004306)1.98723841
114Abnormality of the peritoneum (HP:0002585)1.98660986
115Abnormality of complement system (HP:0005339)1.98461403
116Polycythemia (HP:0001901)1.97753433
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.97620276
118Abnormal platelet volume (HP:0011876)1.96929669
119Cervical subluxation (HP:0003308)1.96730267
120Recurrent pneumonia (HP:0006532)1.96707271
121Spondylolisthesis (HP:0003302)1.96128256
122Pathologic fracture (HP:0002756)1.95082054
123Vertigo (HP:0002321)1.94676179
124Polyneuropathy (HP:0001271)1.93293209
125Keratoconjunctivitis (HP:0001096)1.92530115
126Malnutrition (HP:0004395)1.92099512
127Cerebral aneurysm (HP:0004944)1.90610836
128Abnormality of the pericardium (HP:0001697)1.89704434
129Chest pain (HP:0100749)1.89171340
130Abnormality of the thoracic spine (HP:0100711)1.88802683
131Deformed sella turcica (HP:0002681)1.86657586
132Skin ulcer (HP:0200042)1.83947475
133Vertebral compression fractures (HP:0002953)1.81803278
134Pulmonary embolism (HP:0002204)1.80258443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.38933033
2MAP4K13.30356872
3BLK2.97257703
4RIPK42.77511910
5TYK22.67567940
6TBK12.66387878
7ERN12.55798650
8KIT2.54935776
9EPHB12.52334831
10PRPF4B2.35273656
11MAP3K142.33478223
12TRIB32.30112287
13FES2.17891028
14IRAK32.16173790
15PKN22.12238658
16STK102.01990063
17TAOK12.00996861
18TAOK31.96116413
19CSK1.92725235
20TXK1.88199238
21IKBKE1.87714470
22BTK1.84744786
23TTN1.81743356
24JAK11.78994223
25ZAP701.76135669
26FGR1.75636516
27HCK1.73872515
28JAK31.72972032
29CAMK1D1.72254790
30CSF1R1.71300824
31IKBKB1.44058262
32MAP2K31.43176059
33SIK31.41619316
34LRRK21.38873124
35TGFBR21.37546108
36PTK61.36753409
37RIPK11.33430199
38SYK1.32943203
39MAP3K11.31823671
40CAMK1G1.30550968
41MAP3K131.30499023
42SIK21.28477808
43CDK121.28289321
44TEC1.28020608
45GRK61.17626008
46LCK1.15256411
47TAOK21.13002230
48PIM21.12917768
49PAK41.11614929
50PIM11.11570095
51MARK31.11071862
52KSR21.10242380
53TRPM71.09586818
54BMX1.09424045
55RPS6KA41.08211846
56YES11.05776492
57ITK1.03623048
58LYN1.00904446
59GRK70.99407683
60MARK20.96393551
61IRAK10.93211439
62PRKD20.90098138
63IRAK20.89542201
64JAK20.89181263
65MATK0.85640556
66CDC42BPA0.81494137
67CHUK0.79362200
68BMPR20.78877820
69MAP3K60.77597597
70EEF2K0.76464531
71CLK10.75787070
72ALK0.73480492
73TESK20.72324282
74EGFR0.70986618
75MAP3K110.67774145
76FGFR30.64315426
77CDK190.63914346
78SMG10.63680397
79PRKG20.63279832
80NEK90.62991235
81MAPK120.62854711
82MAP3K30.62203376
83MAPK70.60085527
84MAP3K100.57225820
85CDK60.56115047
86NEK20.55107101
87RPS6KA60.54761976
88ABL10.53572288
89MAP3K70.53239494
90MAP2K60.52502696
91MAP2K40.52362276
92DAPK20.51781757
93MST1R0.50812046
94MAPKAPK20.50104114
95MOS0.49848523
96EPHA30.48927899
97FGFR40.48894477
98HIPK20.48751285
99DYRK1B0.47909824
100CAMKK20.47596701
101STK40.47407765
102NME20.46681973
103RPS6KC10.46233918
104RPS6KL10.46233918
105MAP3K80.45508195
106PTK20.45444412
107MAP3K20.45046215
108STK110.43279667
109RPS6KA20.43148186
110FYN0.42478197
111FLT30.41881173
112CAMKK10.40820229
113STK240.40042343
114PRKCD0.39278786
115PDGFRB0.39005334
116STK30.39002466
117PDPK10.37113434
118CDK40.35922958
119MAP3K50.35864383
120SGK30.35686234
121TESK10.35155170
122SIK10.35043001
123PTK2B0.34871307
124PDK10.34731297
125PIK3CG0.34706131
126RET0.34030698
127MAPK40.33315841
128TNK20.32894370
129PRKCH0.32177782
130KDR0.31822553
131ABL20.31412022
132ACVR1B0.31252263
133KSR10.30291378
134PRKCQ0.30113566
135RAF10.28082053

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.50271679
2Leishmaniasis_Homo sapiens_hsa051403.37824884
3Osteoclast differentiation_Homo sapiens_hsa043802.58951955
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.40968526
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.25971089
6Other glycan degradation_Homo sapiens_hsa005112.24135885
7Pertussis_Homo sapiens_hsa051332.22502658
8Lysosome_Homo sapiens_hsa041422.14011369
9Tuberculosis_Homo sapiens_hsa051522.09666058
10Malaria_Homo sapiens_hsa051442.02817844
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.02360998
12B cell receptor signaling pathway_Homo sapiens_hsa046621.98824601
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.97456779
14Legionellosis_Homo sapiens_hsa051341.90657196
15Measles_Homo sapiens_hsa051621.86923610
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83506824
17Caffeine metabolism_Homo sapiens_hsa002321.82521426
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74978440
19Shigellosis_Homo sapiens_hsa051311.69834961
20Toxoplasmosis_Homo sapiens_hsa051451.68089496
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64026948
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63478714
23Influenza A_Homo sapiens_hsa051641.61494972
24Phagosome_Homo sapiens_hsa041451.57085780
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.56941630
26Antigen processing and presentation_Homo sapiens_hsa046121.55718774
27Graft-versus-host disease_Homo sapiens_hsa053321.55612952
28TNF signaling pathway_Homo sapiens_hsa046681.53706878
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.50892786
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50279384
31Hematopoietic cell lineage_Homo sapiens_hsa046401.49658148
32Asthma_Homo sapiens_hsa053101.48226188
33Salmonella infection_Homo sapiens_hsa051321.46745895
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42274284
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42268473
36Allograft rejection_Homo sapiens_hsa053301.41970688
37Chemokine signaling pathway_Homo sapiens_hsa040621.41664121
38Apoptosis_Homo sapiens_hsa042101.41488444
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34361095
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33436556
41Rheumatoid arthritis_Homo sapiens_hsa053231.29455674
42Herpes simplex infection_Homo sapiens_hsa051681.26544596
43Hepatitis B_Homo sapiens_hsa051611.25566323
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.23324429
45Acute myeloid leukemia_Homo sapiens_hsa052211.21393523
46Chronic myeloid leukemia_Homo sapiens_hsa052201.19685082
47Viral myocarditis_Homo sapiens_hsa054161.13448151
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11549769
49Pancreatic cancer_Homo sapiens_hsa052121.09596523
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07221084
51Hepatitis C_Homo sapiens_hsa051601.04540335
52Amoebiasis_Homo sapiens_hsa051461.04248700
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03847763
54Platelet activation_Homo sapiens_hsa046111.02388610
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99800747
56T cell receptor signaling pathway_Homo sapiens_hsa046600.94957792
57Complement and coagulation cascades_Homo sapiens_hsa046100.92786712
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90700190
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.88650866
60VEGF signaling pathway_Homo sapiens_hsa043700.78551980
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78386883
62Primary immunodeficiency_Homo sapiens_hsa053400.77708406
63Small cell lung cancer_Homo sapiens_hsa052220.77653576
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74276712
65African trypanosomiasis_Homo sapiens_hsa051430.71643717
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68142839
67Prolactin signaling pathway_Homo sapiens_hsa049170.65323105
68Proteoglycans in cancer_Homo sapiens_hsa052050.64855732
69Non-small cell lung cancer_Homo sapiens_hsa052230.64160913
70Epstein-Barr virus infection_Homo sapiens_hsa051690.63715165
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61883126
72Viral carcinogenesis_Homo sapiens_hsa052030.61083533
73Endocytosis_Homo sapiens_hsa041440.60039382
74HIF-1 signaling pathway_Homo sapiens_hsa040660.59439203
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58612347
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.57357558
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.57129047
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55990065
79Type I diabetes mellitus_Homo sapiens_hsa049400.53805306
80GnRH signaling pathway_Homo sapiens_hsa049120.53055481
81Insulin resistance_Homo sapiens_hsa049310.50836227
82Collecting duct acid secretion_Homo sapiens_hsa049660.49725762
83Autoimmune thyroid disease_Homo sapiens_hsa053200.48877001
84Focal adhesion_Homo sapiens_hsa045100.47100968
85HTLV-I infection_Homo sapiens_hsa051660.46710016
86Dorso-ventral axis formation_Homo sapiens_hsa043200.45904636
87Renal cell carcinoma_Homo sapiens_hsa052110.44991878
88Choline metabolism in cancer_Homo sapiens_hsa052310.44157365
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43119135
90Notch signaling pathway_Homo sapiens_hsa043300.42888827
91MicroRNAs in cancer_Homo sapiens_hsa052060.42802005
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41727100
93Type II diabetes mellitus_Homo sapiens_hsa049300.41405142
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41385231
95Endometrial cancer_Homo sapiens_hsa052130.39827433
96Colorectal cancer_Homo sapiens_hsa052100.39370831
97Pentose phosphate pathway_Homo sapiens_hsa000300.37081963
98MAPK signaling pathway_Homo sapiens_hsa040100.36219643
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35696984
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.34965882
101mTOR signaling pathway_Homo sapiens_hsa041500.34598430
102Prostate cancer_Homo sapiens_hsa052150.34195834
103Glioma_Homo sapiens_hsa052140.33239795
104Inositol phosphate metabolism_Homo sapiens_hsa005620.32193176
105Regulation of autophagy_Homo sapiens_hsa041400.31249437
106FoxO signaling pathway_Homo sapiens_hsa040680.30667570
107Renin-angiotensin system_Homo sapiens_hsa046140.28999727
108Rap1 signaling pathway_Homo sapiens_hsa040150.28926835
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27562776
110Bladder cancer_Homo sapiens_hsa052190.27128609
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26147126
112Galactose metabolism_Homo sapiens_hsa000520.26138816
113Prion diseases_Homo sapiens_hsa050200.25093297
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.25039260

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