APOC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.55100615
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55100615
3L-phenylalanine metabolic process (GO:0006558)7.24931520
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.24931520
5exogenous drug catabolic process (GO:0042738)6.96870079
6aromatic amino acid family catabolic process (GO:0009074)6.80694184
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.61927487
8epoxygenase P450 pathway (GO:0019373)6.19413585
9indole-containing compound catabolic process (GO:0042436)6.15648230
10indolalkylamine catabolic process (GO:0046218)6.15648230
11tryptophan catabolic process (GO:0006569)6.15648230
12kynurenine metabolic process (GO:0070189)6.02187304
13omega-hydroxylase P450 pathway (GO:0097267)5.96959739
14bile acid biosynthetic process (GO:0006699)5.94050169
15tryptophan metabolic process (GO:0006568)5.79511549
16glyoxylate metabolic process (GO:0046487)5.71646220
17negative regulation of fibrinolysis (GO:0051918)5.71629113
18urea cycle (GO:0000050)5.68569167
19urea metabolic process (GO:0019627)5.68569167
20alpha-linolenic acid metabolic process (GO:0036109)5.65036429
21regulation of fibrinolysis (GO:0051917)5.48219525
22* high-density lipoprotein particle remodeling (GO:0034375)5.47175536
23protein carboxylation (GO:0018214)5.42203014
24peptidyl-glutamic acid carboxylation (GO:0017187)5.42203014
25sulfur amino acid catabolic process (GO:0000098)5.33744358
26cysteine metabolic process (GO:0006534)5.29112669
27complement activation, alternative pathway (GO:0006957)5.28133788
28regulation of protein activation cascade (GO:2000257)5.26206629
29nitrogen cycle metabolic process (GO:0071941)5.22860830
30serine family amino acid catabolic process (GO:0009071)5.11120417
31bile acid metabolic process (GO:0008206)5.08704998
32regulation of triglyceride catabolic process (GO:0010896)5.05047843
33reverse cholesterol transport (GO:0043691)5.04836868
34regulation of plasminogen activation (GO:0010755)5.01717834
35aromatic amino acid family metabolic process (GO:0009072)4.95901454
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91929390
37regulation of complement activation (GO:0030449)4.89360653
38negative regulation of blood coagulation (GO:0030195)4.83294904
39negative regulation of hemostasis (GO:1900047)4.83294904
40tyrosine metabolic process (GO:0006570)4.80862898
41* plasma lipoprotein particle remodeling (GO:0034369)4.73846657
42* protein-lipid complex remodeling (GO:0034368)4.73846657
43* macromolecular complex remodeling (GO:0034367)4.73846657
44acylglycerol homeostasis (GO:0055090)4.71328290
45triglyceride homeostasis (GO:0070328)4.71328290
46homocysteine metabolic process (GO:0050667)4.69828950
47amino-acid betaine metabolic process (GO:0006577)4.63317241
48alpha-amino acid catabolic process (GO:1901606)4.62780233
49drug metabolic process (GO:0017144)4.60767262
50* regulation of cholesterol esterification (GO:0010872)4.56562046
51fat-soluble vitamin biosynthetic process (GO:0042362)4.56365675
52lysine catabolic process (GO:0006554)4.53202209
53lysine metabolic process (GO:0006553)4.53202209
54negative regulation of coagulation (GO:0050819)4.44735498
55* phospholipid efflux (GO:0033700)4.40842075
56cellular ketone body metabolic process (GO:0046950)4.39215664
57glycine metabolic process (GO:0006544)4.38411830
58bile acid and bile salt transport (GO:0015721)4.36092912
59indolalkylamine metabolic process (GO:0006586)4.35634458
60oxidative demethylation (GO:0070989)4.34952132
61positive regulation of blood coagulation (GO:0030194)4.34832968
62positive regulation of hemostasis (GO:1900048)4.34832968
63coenzyme catabolic process (GO:0009109)4.34384051
64* negative regulation of cholesterol transport (GO:0032375)4.33667975
65* negative regulation of sterol transport (GO:0032372)4.33667975
66ethanol metabolic process (GO:0006067)4.31619435
67* plasma lipoprotein particle clearance (GO:0034381)4.30180455
68imidazole-containing compound metabolic process (GO:0052803)4.28945932
69amine catabolic process (GO:0009310)4.28454097
70cellular biogenic amine catabolic process (GO:0042402)4.28454097
71cellular glucuronidation (GO:0052695)4.25504000
72cellular amino acid catabolic process (GO:0009063)4.25379118
73negative regulation of wound healing (GO:0061045)4.22770856
74phenylpropanoid metabolic process (GO:0009698)4.21477718
75benzene-containing compound metabolic process (GO:0042537)4.21366168
76glutamate metabolic process (GO:0006536)4.17072453
77low-density lipoprotein particle remodeling (GO:0034374)4.17066817
78serine family amino acid metabolic process (GO:0009069)4.14801610
79* cholesterol efflux (GO:0033344)4.14662997
80positive regulation of coagulation (GO:0050820)4.08669960
81fibrinolysis (GO:0042730)4.08528327
82* plasma lipoprotein particle organization (GO:0071827)4.05888624
83ethanol oxidation (GO:0006069)4.05080651
84arginine metabolic process (GO:0006525)4.03024138
85cellular modified amino acid catabolic process (GO:0042219)4.01135750
86dicarboxylic acid biosynthetic process (GO:0043650)4.00058064
87serine family amino acid biosynthetic process (GO:0009070)3.98947197
88drug catabolic process (GO:0042737)3.98912056
89aldehyde catabolic process (GO:0046185)3.98021101
90positive regulation of lipid catabolic process (GO:0050996)3.95991455
91positive regulation of fatty acid biosynthetic process (GO:0045723)3.95713594
92positive regulation of triglyceride lipase activity (GO:0061365)3.92520509
93positive regulation of lipoprotein lipase activity (GO:0051006)3.92520509
94blood coagulation, intrinsic pathway (GO:0007597)3.86944783
95* protein-lipid complex subunit organization (GO:0071825)3.85305926
96regulation of humoral immune response (GO:0002920)3.85124157
97* plasma lipoprotein particle assembly (GO:0034377)3.82120701
98cofactor catabolic process (GO:0051187)3.82012629
99cholesterol homeostasis (GO:0042632)3.80271160
100* protein-lipid complex assembly (GO:0065005)3.80190345
101ketone body metabolic process (GO:1902224)3.80018720
102glucuronate metabolic process (GO:0019585)3.77341527
103uronic acid metabolic process (GO:0006063)3.77341527
104phospholipid homeostasis (GO:0055091)3.76185907
105heme transport (GO:0015886)3.75736262
106complement activation, classical pathway (GO:0006958)3.74259667
107organic acid catabolic process (GO:0016054)3.74104575
108carboxylic acid catabolic process (GO:0046395)3.74104575
109sterol homeostasis (GO:0055092)3.73773653
110positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.71964206
111regulation of apoptotic cell clearance (GO:2000425)3.71074357
112short-chain fatty acid metabolic process (GO:0046459)3.71060385
113complement activation (GO:0006956)3.70499930
114protein activation cascade (GO:0072376)3.70426773
115negative regulation of protein activation cascade (GO:2000258)3.68797678
116regulation of bile acid biosynthetic process (GO:0070857)3.66302999
117acetyl-CoA metabolic process (GO:0006084)3.65831098
118* negative regulation of lipase activity (GO:0060192)3.63307465
119positive regulation of fatty acid beta-oxidation (GO:0032000)3.62070967
120acute-phase response (GO:0006953)3.61441495
121opsonization (GO:0008228)3.61239581
122NAD biosynthetic process (GO:0009435)3.59921027
123regulation of cholesterol homeostasis (GO:2000188)3.58471600
124cytolysis (GO:0019835)3.58300440
125S-adenosylmethionine metabolic process (GO:0046500)3.56736896
126nicotinamide nucleotide biosynthetic process (GO:0019359)3.56713787
127intestinal cholesterol absorption (GO:0030299)3.54558062
128alkaloid metabolic process (GO:0009820)3.43560836
129* very-low-density lipoprotein particle assembly (GO:0034379)3.38999634
130* lipoprotein metabolic process (GO:0042157)3.36007144
131* negative regulation of lipid transport (GO:0032369)3.33731140
132steroid catabolic process (GO:0006706)3.32462752
133acute inflammatory response (GO:0002526)3.28272809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.35739804
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18876026
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.06747670
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48878577
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31230035
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19287351
7* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.96755014
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04443914
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03486707
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09352529
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06926634
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02203710
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9459433
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65923452
15CLOCK_20551151_ChIP-Seq_293T_Human1.60523114
16BP1_19119308_ChIP-ChIP_Hs578T_Human1.59925236
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.57656711
18HTT_18923047_ChIP-ChIP_STHdh_Human1.54163457
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.45848781
20GATA1_22025678_ChIP-Seq_K562_Human1.40123133
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.39167045
22HNF4A_19822575_ChIP-Seq_HepG2_Human1.39132571
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34658866
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30437903
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27154169
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25015124
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23966486
28RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19847583
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09964041
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09869935
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09125141
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03027643
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02219491
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99752908
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94021498
36SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92872210
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90125547
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89174707
39IRF8_22096565_ChIP-ChIP_GC-B_Human0.87108035
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86514865
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86169946
42AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83832279
43ELF1_20517297_ChIP-Seq_JURKAT_Human0.83577051
44BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83193674
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82794497
46GATA4_25053715_ChIP-Seq_YYC3_Human0.82610703
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81897553
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80454494
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80043702
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79131261
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78821931
52ZNF263_19887448_ChIP-Seq_K562_Human0.78300739
53SPI1_20517297_ChIP-Seq_HL60_Human0.77710972
54* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74392171
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74121079
56RARA_24833708_ChIP-Seq_LIVER_Mouse0.73905569
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73419576
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73221146
59BCOR_27268052_Chip-Seq_Bcells_Human0.71846250
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71230299
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70790748
62* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70114060
63ESR2_21235772_ChIP-Seq_MCF-7_Human0.69578063
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.67690821
65BCL6_27268052_Chip-Seq_Bcells_Human0.67275112
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66579108
67* SOX2_20726797_ChIP-Seq_SW620_Human0.66086951
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65594432
69SA1_27219007_Chip-Seq_Bcells_Human0.65298131
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64181558
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64105101
72* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63765536
73* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63625586
74RARB_24833708_ChIP-Seq_LIVER_Mouse0.63563587
75MYB_21317192_ChIP-Seq_ERMYB_Mouse0.63556333
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63505608
77NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63505608
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.62934332
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62425653
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62350649
81RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62301698
82* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.62083924
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61794423
84* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61742721
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61510592
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61056662
87* SOX2_21211035_ChIP-Seq_LN229_Human0.61021273
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60621461
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.60078935
90NFIB_24661679_ChIP-Seq_LUNG_Mouse0.59413480
91VDR_24787735_ChIP-Seq_THP-1_Human0.58313416
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.57331906
93* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56924181
94* CEBPB_22108803_ChIP-Seq_LS180_Human0.56880032
95GATA3_21867929_ChIP-Seq_CD8_Mouse0.56474317
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56236625
97* CTCF_20526341_ChIP-Seq_ESCs_Human0.54578586
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53970478
99EGR1_19032775_ChIP-ChIP_M12_Human0.53541655
100AR_20517297_ChIP-Seq_VCAP_Human0.52934235
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51188974
102FOXA1_25552417_ChIP-Seq_VCAP_Human0.50859620
103* LXR_22292898_ChIP-Seq_THP-1_Human0.50498786
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50123647
105MYC_19915707_ChIP-ChIP_AK7_Human0.49286580
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.49242754
107PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48365275
108ESET_19884257_ChIP-Seq_ESCs_Mouse0.48086164
109CBP_21632823_ChIP-Seq_H3396_Human0.47569489
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.46719532
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46099602
112STAT1_17558387_ChIP-Seq_HELA_Human0.45269013
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.43900090
114* P53_21459846_ChIP-Seq_SAOS-2_Human0.43787371
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43261646
116BCAT_22108803_ChIP-Seq_LS180_Human0.42087551
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41742313
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41644199
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41511840
120GATA6_25053715_ChIP-Seq_YYC3_Human0.40816271
121TAF2_19829295_ChIP-Seq_ESCs_Human0.40324653
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39533691
123TAF15_26573619_Chip-Seq_HEK293_Human0.38911047
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.37544729
125GATA1_19941826_ChIP-Seq_K562_Human0.37456745
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.37182586
127GATA2_19941826_ChIP-Seq_K562_Human0.37153875
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.35675484
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35212706
130FOXH1_21741376_ChIP-Seq_EPCs_Human0.35041921
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.34939534
132SPI1_26923725_Chip-Seq_HPCs_Mouse0.34899937
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.34847759
134* GATA1_19941827_ChIP-Seq_MEL_Mouse0.34482343
135NCOR_22424771_ChIP-Seq_293T_Human0.34440244
136LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34157465
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.33675543
138CDX2_22108803_ChIP-Seq_LS180_Human0.33400590
139ERG_20517297_ChIP-Seq_VCAP_Human0.33207671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.51514522
2MP0005360_urolithiasis7.48065018
3* MP0005085_abnormal_gallbladder_physiolo6.16060531
4* MP0005365_abnormal_bile_salt5.98900254
5MP0008875_abnormal_xenobiotic_pharmacok5.15276709
6MP0003806_abnormal_nucleotide_metabolis4.21000217
7MP0003252_abnormal_bile_duct3.88098800
8MP0010329_abnormal_lipoprotein_level3.65281002
9MP0009840_abnormal_foam_cell3.46574862
10MP0005083_abnormal_biliary_tract3.01543980
11MP0003195_calcinosis2.85060866
12MP0005332_abnormal_amino_acid2.75947275
13MP0001666_abnormal_nutrient_absorption2.60838925
14MP0005058_abnormal_lysosome_morphology2.59007130
15MP0003191_abnormal_cellular_cholesterol2.39542276
16MP0004019_abnormal_vitamin_homeostasis2.16082205
17* MP0000609_abnormal_liver_physiology2.15107525
18* MP0002118_abnormal_lipid_homeostasis2.10486935
19MP0002138_abnormal_hepatobiliary_system1.97351109
20MP0003868_abnormal_feces_composition1.85520408
21MP0005319_abnormal_enzyme/_coenzyme1.81938497
22MP0001764_abnormal_homeostasis1.69664846
23MP0009697_abnormal_copulation1.66224626
24MP0005584_abnormal_enzyme/coenzyme_acti1.55716873
25MP0003011_delayed_dark_adaptation1.51076749
26MP0005451_abnormal_body_composition1.49153576
27MP0003172_abnormal_lysosome_physiology1.34188483
28MP0003186_abnormal_redox_activity1.30328664
29MP0009643_abnormal_urine_homeostasis1.24487803
30MP0003656_abnormal_erythrocyte_physiolo1.19595788
31MP0003705_abnormal_hypodermis_morpholog1.16409852
32MP0000598_abnormal_liver_morphology1.16126278
33MP0005647_abnormal_sex_gland1.15969781
34MP0002254_reproductive_system_inflammat1.11301387
35MP0000604_amyloidosis1.09165473
36MP0009764_decreased_sensitivity_to1.06455734
37MP0009763_increased_sensitivity_to1.02717668
38MP0005636_abnormal_mineral_homeostasis0.95216039
39MP0009785_altered_susceptibility_to0.93172738
40MP0010368_abnormal_lymphatic_system0.91405038
41MP0008469_abnormal_protein_level0.89368476
42MP0002419_abnormal_innate_immunity0.87892770
43MP0005670_abnormal_white_adipose0.86675095
44* MP0009642_abnormal_blood_homeostasis0.86489297
45MP0001915_intracranial_hemorrhage0.86468792
46MP0000343_altered_response_to0.85324307
47MP0005408_hypopigmentation0.84762694
48MP0003879_abnormal_hair_cell0.84651163
49MP0006036_abnormal_mitochondrial_physio0.82266780
50MP0005376_homeostasis/metabolism_phenot0.80511739
51MP0009765_abnormal_xenobiotic_induced0.78343209
52MP0002078_abnormal_glucose_homeostasis0.77061491
53MP0005084_abnormal_gallbladder_morpholo0.76944380
54MP0002971_abnormal_brown_adipose0.75398698
55MP0002876_abnormal_thyroid_physiology0.75279985
56MP0009053_abnormal_anal_canal0.72356514
57MP0003303_peritoneal_inflammation0.71797132
58MP0005334_abnormal_fat_pad0.71115747
59MP0004130_abnormal_muscle_cell0.70445703
60MP0005167_abnormal_blood-brain_barrier0.69179001
61MP0003690_abnormal_glial_cell0.69173122
62MP0005220_abnormal_exocrine_pancreas0.68347958
63MP0002090_abnormal_vision0.67667795
64MP0001661_extended_life_span0.66123153
65MP0000920_abnormal_myelination0.65658196
66MP0005535_abnormal_body_temperature0.65481934
67MP0001545_abnormal_hematopoietic_system0.64576468
68MP0005397_hematopoietic_system_phenotyp0.64576468
69MP0003329_amyloid_beta_deposits0.64041545
70MP0002148_abnormal_hypersensitivity_rea0.63988088
71MP0005266_abnormal_metabolism0.63832503
72MP0005025_abnormal_response_to0.62807760
73MP0000639_abnormal_adrenal_gland0.61202226
74MP0003632_abnormal_nervous_system0.60882523
75MP0001756_abnormal_urination0.59122195
76MP0005448_abnormal_energy_balance0.55327477
77MP0002998_abnormal_bone_remodeling0.54601832
78MP0006035_abnormal_mitochondrial_morpho0.54406073
79MP0009333_abnormal_splenocyte_physiolog0.53580767
80MP0005464_abnormal_platelet_physiology0.53525984
81MP0000685_abnormal_immune_system0.53268851
82MP0005257_abnormal_intraocular_pressure0.51968865
83MP0002796_impaired_skin_barrier0.50747010
84MP0001533_abnormal_skeleton_physiology0.49931934
85MP0004381_abnormal_hair_follicle0.49843304
86MP0005023_abnormal_wound_healing0.49186476
87MP0005395_other_phenotype0.48998036
88MP0003638_abnormal_response/metabolism_0.47900916
89MP0003718_maternal_effect0.47108100
90MP0000858_altered_metastatic_potential0.45980727
91MP0002136_abnormal_kidney_physiology0.45770874
92MP0008874_decreased_physiological_sensi0.45559596
93MP0008873_increased_physiological_sensi0.45435819
94MP0002822_catalepsy0.44846584
95MP0004782_abnormal_surfactant_physiolog0.43455837
96MP0005666_abnormal_adipose_tissue0.43188705
97MP0005379_endocrine/exocrine_gland_phen0.42887583
98MP0003724_increased_susceptibility_to0.42872988
99MP0005646_abnormal_pituitary_gland0.41608489
100MP0005248_abnormal_Harderian_gland0.41393195
101MP0002909_abnormal_adrenal_gland0.41338764
102MP0002928_abnormal_bile_duct0.41217586
103MP0003953_abnormal_hormone_level0.40607988
104MP0003436_decreased_susceptibility_to0.40333467
105MP0000579_abnormal_nail_morphology0.40041061
106MP0003075_altered_response_to0.39763700
107MP0002837_dystrophic_cardiac_calcinosis0.37709837
108MP0005387_immune_system_phenotype0.37102438
109MP0001790_abnormal_immune_system0.37102438
110MP0008872_abnormal_physiological_respon0.36423694
111MP0009115_abnormal_fat_cell0.35785049
112MP0001243_abnormal_dermal_layer0.35662848
113MP0009672_abnormal_birth_weight0.35184994
114MP0005166_decreased_susceptibility_to0.34981486
115MP0002060_abnormal_skin_morphology0.33312741
116MP0001853_heart_inflammation0.33035430
117MP0001881_abnormal_mammary_gland0.32960666
118MP0004883_abnormal_blood_vessel0.32659093
119MP0002970_abnormal_white_adipose0.32476745
120MP0000249_abnormal_blood_vessel0.32358971
121MP0002168_other_aberrant_phenotype0.31423462
122MP0009384_cardiac_valve_regurgitation0.29961001
123MP0000230_abnormal_systemic_arterial0.29477556
124MP0002132_abnormal_respiratory_system0.29462458
125MP0006082_CNS_inflammation0.28734473
126MP0001845_abnormal_inflammatory_respons0.27071675
127MP0003453_abnormal_keratinocyte_physiol0.26881434
128MP0005164_abnormal_response_to0.26774501

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.41638376
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36556136
3Intrahepatic cholestasis (HP:0001406)7.24129308
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75080382
5Prolonged partial thromboplastin time (HP:0003645)6.60726344
6Hypobetalipoproteinemia (HP:0003563)6.58006841
7Xanthomatosis (HP:0000991)6.36896377
8Hyperlipoproteinemia (HP:0010980)5.69767707
9Complement deficiency (HP:0004431)5.27654500
10Hypolipoproteinemia (HP:0010981)4.93052752
11Joint hemorrhage (HP:0005261)4.80727566
12Hyperammonemia (HP:0001987)4.62186363
13Epidermoid cyst (HP:0200040)4.56042652
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.51425283
15Abnormality of the common coagulation pathway (HP:0010990)4.44352162
16Hyperglycinemia (HP:0002154)4.38622985
17Hypoalphalipoproteinemia (HP:0003233)4.30600105
18Abnormality of methionine metabolism (HP:0010901)4.29108878
19Ketosis (HP:0001946)4.26425185
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.21389464
21Fat malabsorption (HP:0002630)4.11513161
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09624398
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07640541
24Hypoglycemic coma (HP:0001325)4.00314815
25Hyperglycinuria (HP:0003108)3.93111208
26Abnormality of serine family amino acid metabolism (HP:0010894)3.90003318
27Abnormality of glycine metabolism (HP:0010895)3.90003318
28Abnormality of glycolipid metabolism (HP:0010969)3.88323294
29Abnormality of liposaccharide metabolism (HP:0010968)3.88323294
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.88323294
31Abnormality of pyrimidine metabolism (HP:0004353)3.87953416
32Abnormality of complement system (HP:0005339)3.85760505
33Abnormality of the intrinsic pathway (HP:0010989)3.74297285
34Hypercholesterolemia (HP:0003124)3.70497994
35Conjugated hyperbilirubinemia (HP:0002908)3.66232625
36Purpura (HP:0000979)3.47804121
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38050864
38Abnormality of fatty-acid metabolism (HP:0004359)3.36972982
39Hyperbilirubinemia (HP:0002904)3.33522169
40Steatorrhea (HP:0002570)3.11705442
41Delayed CNS myelination (HP:0002188)3.07709744
42Abnormality of nucleobase metabolism (HP:0010932)3.06328702
43Ketoacidosis (HP:0001993)3.04930374
44Abnormality of serum amino acid levels (HP:0003112)3.04850767
45Spontaneous abortion (HP:0005268)3.02638976
46Myocardial infarction (HP:0001658)2.93914325
47Hypochromic microcytic anemia (HP:0004840)2.92670517
48Hepatocellular carcinoma (HP:0001402)2.90707215
49Skin nodule (HP:0200036)2.77727821
50Retinal atrophy (HP:0001105)2.75967437
51Metabolic acidosis (HP:0001942)2.74522408
52Vacuolated lymphocytes (HP:0001922)2.72223516
53Systemic lupus erythematosus (HP:0002725)2.67932306
54Abnormality of purine metabolism (HP:0004352)2.65516346
55Lethargy (HP:0001254)2.64243279
56Vascular calcification (HP:0004934)2.62495894
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60963769
58Dicarboxylic aciduria (HP:0003215)2.60963769
59Hypoglycemic seizures (HP:0002173)2.57763265
60Acanthocytosis (HP:0001927)2.51883063
61Increased serum ferritin (HP:0003281)2.51255022
62Neurofibrillary tangles (HP:0002185)2.50798803
63Cerebral edema (HP:0002181)2.49142484
64Glomerulonephritis (HP:0000099)2.45556718
65Abnormal gallbladder morphology (HP:0012437)2.45547973
66Spastic diplegia (HP:0001264)2.44076967
67Abnormal gallbladder physiology (HP:0012438)2.40873879
68Cholecystitis (HP:0001082)2.40873879
69Mitral stenosis (HP:0001718)2.40759274
70Amyloidosis (HP:0011034)2.40288466
71Cholelithiasis (HP:0001081)2.39567735
72Irritability (HP:0000737)2.35640571
73Neonatal onset (HP:0003623)2.32967681
74Cardiovascular calcification (HP:0011915)2.32490314
75Urinary glycosaminoglycan excretion (HP:0003541)2.31766242
76Mucopolysacchariduria (HP:0008155)2.31766242
77Gout (HP:0001997)2.31436583
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30429907
79Abnormality of polysaccharide metabolism (HP:0011012)2.30429907
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30429907
81Pulmonary embolism (HP:0002204)2.28690453
82Increased cerebral lipofuscin (HP:0011813)2.28075753
83Gingival bleeding (HP:0000225)2.24542649
84Late onset (HP:0003584)2.23970692
85Recurrent gram-negative bacterial infections (HP:0005420)2.23749174
86Malnutrition (HP:0004395)2.23065080
87Esophageal varix (HP:0002040)2.18994993
88Brushfield spots (HP:0001088)2.18507654
89Dysostosis multiplex (HP:0000943)2.16272784
90Menorrhagia (HP:0000132)2.14718839
91Pancreatitis (HP:0001733)2.14272460
92Hyperinsulinemic hypoglycemia (HP:0000825)2.09938503
93Vomiting (HP:0002013)2.07753460
94Sensorimotor neuropathy (HP:0007141)2.07155163
95Abnormality of iron homeostasis (HP:0011031)2.07150406
96Thrombophlebitis (HP:0004418)2.06072454
97Generalized aminoaciduria (HP:0002909)2.05459547
98Enlarged kidneys (HP:0000105)2.03973116
99Abnormality of the Achilles tendon (HP:0005109)2.03310683
100Opisthotonus (HP:0002179)2.02743165
101Abnormality of transition element cation homeostasis (HP:0011030)2.00851710
102Poikilocytosis (HP:0004447)1.99641311
103Abnormality of the gallbladder (HP:0005264)1.98158648
104Hemorrhage of the eye (HP:0011885)1.98035683
105Reduced antithrombin III activity (HP:0001976)1.97784131
106Rickets (HP:0002748)1.94697092
107Osteomalacia (HP:0002749)1.93400920
108Abnormal cartilage morphology (HP:0002763)1.90229050
109Cerebral inclusion bodies (HP:0100314)1.89326444
110Joint swelling (HP:0001386)1.87181508
111Renal cortical cysts (HP:0000803)1.86917412
112Hypophosphatemic rickets (HP:0004912)1.85342037
113Gangrene (HP:0100758)1.83151072
114Nausea (HP:0002018)1.82545057
115Abnormality of proline metabolism (HP:0010907)1.82208604
116Hydroxyprolinuria (HP:0003080)1.82208604
117Hyperglycemia (HP:0003074)1.81774646
118Elevated alkaline phosphatase (HP:0003155)1.80883912
119Elevated hepatic transaminases (HP:0002910)1.79003052
120Nephritis (HP:0000123)1.78559890
121Alkalosis (HP:0001948)1.78377879
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.77211363
123Abnormal enzyme/coenzyme activity (HP:0012379)1.76295533
124Abnormality of vitamin metabolism (HP:0100508)1.75687869
125Increased serum pyruvate (HP:0003542)1.74649191
126Epistaxis (HP:0000421)1.74418514
127Hypertriglyceridemia (HP:0002155)1.72762490
128Status epilepticus (HP:0002133)1.71340802
129Glycosuria (HP:0003076)1.69256408
130Abnormality of urine glucose concentration (HP:0011016)1.69256408
131Polycythemia (HP:0001901)1.68147330
132Abnormality of alkaline phosphatase activity (HP:0004379)1.67646279
133Pathologic fracture (HP:0002756)1.64674482
134Mesangial abnormality (HP:0001966)1.62604235
135Abnormality of the periventricular white matter (HP:0002518)1.61991876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.26456399
2SIK14.61167767
3PDK24.58809525
4FGFR44.52000475
5ERN14.28080200
6NME23.24571917
7TAOK33.02824688
8INSRR2.88184580
9ERBB42.80526913
10MST1R2.39528075
11MAP2K42.24451834
12ACVR1B2.21774378
13BLK2.20788331
14PKN22.19211409
15PIK3CG2.01843716
16FLT31.92922491
17PRPF4B1.84493928
18MAPK111.84437518
19DAPK21.78780413
20TRIB31.78535901
21TYK21.70676718
22LATS11.67770005
23ABL21.50511169
24PTK61.45434013
25GRK71.45114906
26FGFR21.42454589
27MATK1.41300359
28FRK1.37781613
29NEK91.35701925
30PIM21.29254634
31KDR1.27788769
32JAK21.21373519
33CAMKK21.19571273
34DDR21.12671926
35ZAP701.12008427
36PRKAA21.10764160
37MAP3K71.10463185
38MAP3K31.10056417
39PINK11.09226995
40TBK11.07148439
41FGR1.05543763
42MAP2K31.05335330
43STK161.04164733
44TESK21.03933312
45MAP3K141.00485966
46GRK60.98993579
47MAPK40.98804988
48ERBB20.97648033
49JAK10.95839647
50MET0.95719778
51MAPK150.91126493
52PRKCZ0.91028649
53STK38L0.89284281
54MAP3K110.88769603
55MAP3K100.87335295
56CDK60.86082676
57NTRK30.85543237
58MAPK120.81439519
59EPHB10.79904791
60PRKACG0.77045496
61EPHA30.76282083
62CAMK1D0.75405000
63MAP3K20.75218679
64DYRK1B0.74986371
65MAP2K60.74461193
66CAMK2G0.73888960
67TIE10.73412357
68IKBKB0.73083393
69PAK40.71405283
70CSK0.68363492
71GSK3A0.66419891
72RIPK10.64917079
73PDGFRA0.61449567
74IRAK30.61098168
75PRKAA10.60261062
76TGFBR20.59636585
77CSNK2A10.59511554
78MAPK70.58438035
79ARAF0.58331831
80CAMK1G0.56825796
81IKBKE0.56383187
82CDC42BPA0.55546874
83JAK30.55349035
84FGFR30.54760373
85PTK20.53811881
86SGK30.53125739
87MAP2K10.52993864
88CSF1R0.52009838
89MAP3K120.51486434
90EPHA40.51302245
91SCYL20.51217950
92LYN0.51051173
93TAOK20.50783497
94PDPK10.50587350
95PRKG10.49569734
96GRK10.48608947
97PRKCQ0.48238542
98CSNK1G10.48104459
99IGF1R0.46083982
100MAPKAPK30.45834700
101RIPK40.45031952
102MAP3K50.42822430
103CDK40.42718662
104PRKACA0.42611294
105KSR20.41578934
106PRKACB0.41085602
107PBK0.40652616
108PRKG20.40012295
109PRKCG0.38290869
110SGK20.36780777
111MTOR0.36068785
112RET0.35561241
113PIK3CA0.35512899
114LRRK20.35330828
115EIF2AK10.35103373
116SRC0.33718170
117ICK0.33193445
118MAP3K60.32876001
119MAP3K130.32756633
120CSNK2A20.32706818
121PKN10.32668021
122EGFR0.32298315
123PRKCB0.32202475
124CAMK40.31365987
125PDK10.30875347
126MAP3K80.30600537
127LATS20.30493547
128DAPK30.28935071
129SGK10.28501014
130MAP2K20.27059390
131PRKCA0.27051286
132CSNK1G20.26623057
133CHUK0.26415930
134PDK30.26072589
135PDK40.26072589
136TESK10.25879653
137MAP3K10.25689405
138CSNK1G30.25648634
139EPHA20.24227046
140SGK4940.24200827
141SGK2230.24200827
142BMX0.21109466
143ABL10.20649635
144IRAK10.20516821

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50669592
2Nitrogen metabolism_Homo sapiens_hsa009103.49755917
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35639742
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32550346
5Arginine biosynthesis_Homo sapiens_hsa002203.04743897
6Complement and coagulation cascades_Homo sapiens_hsa046102.74701897
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70551551
8Tryptophan metabolism_Homo sapiens_hsa003802.67542931
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60856583
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53328000
11Fatty acid degradation_Homo sapiens_hsa000712.48398809
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38638731
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26419449
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.24701238
15Butanoate metabolism_Homo sapiens_hsa006502.12234512
16Peroxisome_Homo sapiens_hsa041462.09640575
17Chemical carcinogenesis_Homo sapiens_hsa052042.05160633
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03824563
19Propanoate metabolism_Homo sapiens_hsa006401.94049964
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.91903112
21Histidine metabolism_Homo sapiens_hsa003401.91141560
22PPAR signaling pathway_Homo sapiens_hsa033201.90919839
23Fatty acid metabolism_Homo sapiens_hsa012121.81992374
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.78477412
25Staphylococcus aureus infection_Homo sapiens_hsa051501.75607626
26Caffeine metabolism_Homo sapiens_hsa002321.75006099
27Retinol metabolism_Homo sapiens_hsa008301.74015423
28beta-Alanine metabolism_Homo sapiens_hsa004101.71545812
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71273095
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67794448
31Phenylalanine metabolism_Homo sapiens_hsa003601.58804774
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56395282
33Selenocompound metabolism_Homo sapiens_hsa004501.55373717
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51999047
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50589767
36Bile secretion_Homo sapiens_hsa049761.46668277
37Tyrosine metabolism_Homo sapiens_hsa003501.45450295
38Fatty acid elongation_Homo sapiens_hsa000621.37537188
39Pyruvate metabolism_Homo sapiens_hsa006201.35378114
40Other glycan degradation_Homo sapiens_hsa005111.33843384
41Sulfur metabolism_Homo sapiens_hsa009201.33026991
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.31118152
43Starch and sucrose metabolism_Homo sapiens_hsa005001.28155073
44Folate biosynthesis_Homo sapiens_hsa007901.24499437
45Fat digestion and absorption_Homo sapiens_hsa049751.21458872
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19619774
47ABC transporters_Homo sapiens_hsa020101.19242403
48Steroid biosynthesis_Homo sapiens_hsa001001.18068572
49Carbon metabolism_Homo sapiens_hsa012001.13361356
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04759305
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.02957252
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.01021444
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97844305
54Arginine and proline metabolism_Homo sapiens_hsa003300.96408630
55Vitamin B6 metabolism_Homo sapiens_hsa007500.94372456
56Sulfur relay system_Homo sapiens_hsa041220.94027947
57Lysosome_Homo sapiens_hsa041420.87815963
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87767374
59Vitamin digestion and absorption_Homo sapiens_hsa049770.86296903
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79752005
61Lysine degradation_Homo sapiens_hsa003100.78811036
62Glutathione metabolism_Homo sapiens_hsa004800.74366540
63One carbon pool by folate_Homo sapiens_hsa006700.73044827
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71574690
65Pertussis_Homo sapiens_hsa051330.67523769
66Glycerolipid metabolism_Homo sapiens_hsa005610.67452960
67Pentose phosphate pathway_Homo sapiens_hsa000300.59772415
68Fatty acid biosynthesis_Homo sapiens_hsa000610.56652813
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53481225
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49122134
71Metabolic pathways_Homo sapiens_hsa011000.46213560
72Prion diseases_Homo sapiens_hsa050200.32478319
73Mineral absorption_Homo sapiens_hsa049780.27732469
74Galactose metabolism_Homo sapiens_hsa000520.26849359
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26763092
76Fructose and mannose metabolism_Homo sapiens_hsa000510.25354991
77Linoleic acid metabolism_Homo sapiens_hsa005910.23790001
78Insulin resistance_Homo sapiens_hsa049310.21683728
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.21619014
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18105516
81Sphingolipid metabolism_Homo sapiens_hsa006000.17333875
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.16068106
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14396967
84Phagosome_Homo sapiens_hsa041450.13238631
85Glucagon signaling pathway_Homo sapiens_hsa049220.09143800
86Rheumatoid arthritis_Homo sapiens_hsa053230.08999851
87Collecting duct acid secretion_Homo sapiens_hsa049660.04465994
88AMPK signaling pathway_Homo sapiens_hsa041520.01887780
89Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2475632
90Amoebiasis_Homo sapiens_hsa05146-0.2422779
91Ether lipid metabolism_Homo sapiens_hsa00565-0.2422178
92Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2419314
93Bladder cancer_Homo sapiens_hsa05219-0.2282071
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2189214
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2147382
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1999078
97Renin-angiotensin system_Homo sapiens_hsa04614-0.1932934
98Hepatitis C_Homo sapiens_hsa05160-0.1827249
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1680584
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1590972
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1561771
102African trypanosomiasis_Homo sapiens_hsa05143-0.1449465
103Regulation of autophagy_Homo sapiens_hsa04140-0.1387992
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1378988
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1281577
106Asthma_Homo sapiens_hsa05310-0.1054847
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1033807
108Osteoclast differentiation_Homo sapiens_hsa04380-0.0973322
109Leishmaniasis_Homo sapiens_hsa05140-0.0850546
110Tuberculosis_Homo sapiens_hsa05152-0.0802671
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0792009
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0460510
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0113433

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