ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	exogenous drug catabolic process (GO:0042738)	6.61083329
2	drug catabolic process (GO:0042737)	6.34011688
3	glyoxylate metabolic process (GO:0046487)	5.75566399
4	omega-hydroxylase P450 pathway (GO:0097267)	5.19897250
5	indole-containing compound catabolic process (GO:0042436)	5.18255802
6	indolalkylamine catabolic process (GO:0046218)	5.18255802
7	tryptophan catabolic process (GO:0006569)	5.18255802
8	aromatic amino acid family catabolic process (GO:0009074)	5.08809467
9	epoxygenase P450 pathway (GO:0019373)	5.07318909
10	L-phenylalanine catabolic process (GO:0006559)	4.98182340
11	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.98182340
12	cellular ketone body metabolic process (GO:0046950)	4.65271888
13	tryptophan metabolic process (GO:0006568)	4.57255774
14	oxidative demethylation (GO:0070989)	4.55197451
15	S-adenosylmethionine metabolic process (GO:0046500)	4.36780099
16	regulation of fibrinolysis (GO:0051917)	4.35501009
17	serine family amino acid catabolic process (GO:0009071)	4.22508663
18	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.21324649
19	L-phenylalanine metabolic process (GO:0006558)	4.21324649
20	ketone body metabolic process (GO:1902224)	4.21254256
21	indolalkylamine metabolic process (GO:0006586)	4.14143632
22	water-soluble vitamin biosynthetic process (GO:0042364)	4.13754560
23	negative regulation of sterol transport (GO:0032372)	4.07530513
24	negative regulation of cholesterol transport (GO:0032375)	4.07530513
25	drug metabolic process (GO:0017144)	4.04079055
26	regulation of triglyceride catabolic process (GO:0010896)	4.00688935
27	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.88241408
28	ethanol oxidation (GO:0006069)	3.85526134
29	bile acid biosynthetic process (GO:0006699)	3.83745014
30	phenylpropanoid metabolic process (GO:0009698)	3.79467315
31	aromatic amino acid family metabolic process (GO:0009072)	3.77796211
32	kynurenine metabolic process (GO:0070189)	3.72996351
33	negative regulation of fibrinolysis (GO:0051918)	3.72593605
34	cellular biogenic amine catabolic process (GO:0042402)	3.71304514
35	amine catabolic process (GO:0009310)	3.71304514
36	high-density lipoprotein particle remodeling (GO:0034375)	3.70751776
37	complement activation, alternative pathway (GO:0006957)	3.60780228
38	amino acid salvage (GO:0043102)	3.54390461
39	L-methionine salvage (GO:0071267)	3.54390461
40	L-methionine biosynthetic process (GO:0071265)	3.54390461
41	aldehyde catabolic process (GO:0046185)	3.54359278
42	reverse cholesterol transport (GO:0043691)	3.51771391
43	glycine metabolic process (GO:0006544)	3.49907586
44	arginine metabolic process (GO:0006525)	3.49246240
45	phospholipid efflux (GO:0033700)	3.46966453
46	regulation of protein activation cascade (GO:2000257)	3.42546768
47	behavioral response to nicotine (GO:0035095)	3.39572792
48	cholesterol efflux (GO:0033344)	3.36736285
49	blood coagulation, intrinsic pathway (GO:0007597)	3.34200838
50	triglyceride homeostasis (GO:0070328)	3.33923938
51	acylglycerol homeostasis (GO:0055090)	3.33923938
52	alpha-amino acid catabolic process (GO:1901606)	3.27151005
53	DNA deamination (GO:0045006)	3.26885122
54	regulation of complement activation (GO:0030449)	3.25826869
55	regulation of cholesterol esterification (GO:0010872)	3.20116004
56	protein-lipid complex remodeling (GO:0034368)	3.19639208
57	macromolecular complex remodeling (GO:0034367)	3.19639208
58	plasma lipoprotein particle remodeling (GO:0034369)	3.19639208
59	pyrimidine nucleobase catabolic process (GO:0006208)	3.19118125
60	tyrosine metabolic process (GO:0006570)	3.18762937
61	bile acid metabolic process (GO:0008206)	3.17554724
62	peptidyl-glutamic acid carboxylation (GO:0017187)	3.17286176
63	protein carboxylation (GO:0018214)	3.17286176
64	positive regulation of fatty acid transport (GO:2000193)	3.13330058
65	glucuronate metabolic process (GO:0019585)	3.12425948
66	uronic acid metabolic process (GO:0006063)	3.12425948
67	imidazole-containing compound metabolic process (GO:0052803)	3.11432056
68	benzene-containing compound metabolic process (GO:0042537)	3.10936014
69	ethanol metabolic process (GO:0006067)	3.08167172
70	amino-acid betaine metabolic process (GO:0006577)	3.07414461
71	positive regulation of icosanoid secretion (GO:0032305)	3.06992378
72	protein-cofactor linkage (GO:0018065)	3.05693969
73	fibrinolysis (GO:0042730)	3.03810557
74	nucleobase catabolic process (GO:0046113)	3.02848301
75	arginine catabolic process (GO:0006527)	3.02528642
76	indole-containing compound metabolic process (GO:0042430)	3.02096954
77	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.00971130
78	cellular glucuronidation (GO:0052695)	3.00925941
79	serine family amino acid metabolic process (GO:0009069)	3.00255661
80	alkaloid metabolic process (GO:0009820)	2.96896311
81	cellular amino acid catabolic process (GO:0009063)	2.95573892
82	heme transport (GO:0015886)	2.91752318
83	xenobiotic catabolic process (GO:0042178)	2.90948058
84	basic amino acid transport (GO:0015802)	2.88251105
85	vitamin biosynthetic process (GO:0009110)	2.88197195
86	piRNA metabolic process (GO:0034587)	2.86558625
87	dopamine transport (GO:0015872)	2.83725916
88	response to pheromone (GO:0019236)	2.83269557
89	peptidyl-glutamic acid modification (GO:0018200)	2.81327160
90	fucose catabolic process (GO:0019317)	2.80372203
91	L-fucose metabolic process (GO:0042354)	2.80372203
92	L-fucose catabolic process (GO:0042355)	2.80372203
93	respiratory chain complex IV assembly (GO:0008535)	2.78645883
94	protein complex biogenesis (GO:0070271)	2.73793841
95	bile acid and bile salt transport (GO:0015721)	2.71986430
96	methionine biosynthetic process (GO:0009086)	2.71331129
97	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70092744
98	methionine metabolic process (GO:0006555)	2.64183438
99	regulation of lipoprotein particle clearance (GO:0010984)	2.62764124
100	protein polyglutamylation (GO:0018095)	2.61990468

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73110522
2	VDR_22108803_ChIP-Seq_LS180_Human	3.09911454
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.01997493
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.79710013
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.60201314
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52524957
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47448834
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.40183301
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32613351
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.30270906
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.25341412
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21217062
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.16430633
14	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.10812962
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08369144
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.07338593
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06374947
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.99765397
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98043786
20	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.89489416
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79638834
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78223228
23	P300_19829295_ChIP-Seq_ESCs_Human	1.77503551
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.74418187
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.70894054
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70887100
27	FUS_26573619_Chip-Seq_HEK293_Human	1.68679682
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68519562
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.68121996
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.61200774
31	EWS_26573619_Chip-Seq_HEK293_Human	1.57935025
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.57241050
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56950429
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.51711551
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.50416353
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.49296594
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48628976
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45153265
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45153265
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44565887
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.44275468
42	AR_20517297_ChIP-Seq_VCAP_Human	1.42794472
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.42550902
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42550902
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.42382020
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40675404
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40453620
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.39097264
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38837822
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38106415
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38106415
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.37785192
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35139174
54	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.33250329
55	NCOR_22424771_ChIP-Seq_293T_Human	1.31867503
56	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.30892538
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30838086
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30786948
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30560631
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30110454
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28186889
62	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.26625267
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25941403
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25145259
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22727583
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22600990
67	AR_25329375_ChIP-Seq_VCAP_Human	1.20990283
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.20287207
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19085942
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18606351
71	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.17872310
72	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16242436
73	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.16217512
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15721046
75	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.13173634
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12427868
77	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.12276164
78	STAT3_23295773_ChIP-Seq_U87_Human	1.12204918
79	TCF4_23295773_ChIP-Seq_U87_Human	1.11782649
80	MYC_19829295_ChIP-Seq_ESCs_Human	1.11431627
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10573621
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07568090
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07174046
84	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06834151
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06619202
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06551003
87	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06014132
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05157414
89	CDX2_22108803_ChIP-Seq_LS180_Human	1.04934879
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02557642
91	FOXP3_21729870_ChIP-Seq_TREG_Human	1.01579083
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01271706
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00576144
94	PHF8_20622853_ChIP-Seq_HELA_Human	1.00121804
95	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99695523
96	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.99573060
97	* HOXB7_26014856_ChIP-Seq_BT474_Human	0.97896740
98	EZH2_22144423_ChIP-Seq_EOC_Human	0.97399003
99	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.97150360
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95619455

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.29515735
2	MP0002139_abnormal_hepatobiliary_system	4.86948200
3	MP0005360_urolithiasis	4.64347903
4	MP0008875_abnormal_xenobiotic_pharmacok	4.34050077
5	MP0005085_abnormal_gallbladder_physiolo	3.79730206
6	MP0005365_abnormal_bile_salt	3.33727667
7	MP0002138_abnormal_hepatobiliary_system	3.17111939
8	MP0002876_abnormal_thyroid_physiology	2.59434995
9	MP0003252_abnormal_bile_duct	2.53444723
10	MP0010329_abnormal_lipoprotein_level	2.33167616
11	MP0005332_abnormal_amino_acid	2.32259095
12	MP0001986_abnormal_taste_sensitivity	2.16185289
13	MP0008877_abnormal_DNA_methylation	2.11168041
14	MP0003806_abnormal_nucleotide_metabolis	2.08061719
15	MP0006292_abnormal_olfactory_placode	1.99625492
16	MP0008872_abnormal_physiological_respon	1.99363012
17	MP0005646_abnormal_pituitary_gland	1.97271650
18	MP0003011_delayed_dark_adaptation	1.96387106
19	MP0005551_abnormal_eye_electrophysiolog	1.96311664
20	MP0002102_abnormal_ear_morphology	1.93453433
21	MP0000372_irregular_coat_pigmentation	1.80585614
22	MP0001764_abnormal_homeostasis	1.79010911
23	MP0006072_abnormal_retinal_apoptosis	1.75496967
24	MP0002837_dystrophic_cardiac_calcinosis	1.73713915
25	MP0009697_abnormal_copulation	1.67739174
26	MP0005084_abnormal_gallbladder_morpholo	1.67373597
27	MP0005645_abnormal_hypothalamus_physiol	1.55562885
28	MP0001984_abnormal_olfaction	1.50392411
29	MP0001968_abnormal_touch/_nociception	1.50152805
30	MP0001666_abnormal_nutrient_absorption	1.45218483
31	MP0004147_increased_porphyrin_level	1.39224309
32	MP0005253_abnormal_eye_physiology	1.36104775
33	MP0002736_abnormal_nociception_after	1.28701102
34	MP0004885_abnormal_endolymph	1.28150144
35	MP0003718_maternal_effect	1.24623194
36	MP0005379_endocrine/exocrine_gland_phen	1.23575175
37	MP0002938_white_spotting	1.22740493
38	MP0009745_abnormal_behavioral_response	1.19750752
39	MP0003186_abnormal_redox_activity	1.17201988
40	MP0004019_abnormal_vitamin_homeostasis	1.16032663
41	MP0002638_abnormal_pupillary_reflex	1.13303095
42	MP0009046_muscle_twitch	1.12662004
43	MP0003787_abnormal_imprinting	1.11951764
44	MP0004142_abnormal_muscle_tone	1.10394579
45	MP0004043_abnormal_pH_regulation	1.10314571
46	MP0005636_abnormal_mineral_homeostasis	1.08456092
47	MP0004133_heterotaxia	1.08145191
48	MP0009840_abnormal_foam_cell	1.07159981
49	MP0005075_abnormal_melanosome_morpholog	1.07066935
50	MP0002118_abnormal_lipid_homeostasis	1.06293296
51	MP0006036_abnormal_mitochondrial_physio	1.03327151
52	MP0005377_hearing/vestibular/ear_phenot	1.00744338
53	MP0003878_abnormal_ear_physiology	1.00744338
54	MP0002909_abnormal_adrenal_gland	1.00411727
55	MP0003646_muscle_fatigue	0.96969058
56	MP0002272_abnormal_nervous_system	0.96917054
57	MP0001501_abnormal_sleep_pattern	0.95339217
58	MP0002928_abnormal_bile_duct	0.93178489
59	MP0006276_abnormal_autonomic_nervous	0.92796325
60	MP0000609_abnormal_liver_physiology	0.91135045
61	MP0002653_abnormal_ependyma_morphology	0.89220609
62	MP0000427_abnormal_hair_cycle	0.87222787
63	MP0001486_abnormal_startle_reflex	0.86057061
64	MP0003868_abnormal_feces_composition	0.85744051
65	MP0009764_decreased_sensitivity_to	0.85345207
66	MP0002163_abnormal_gland_morphology	0.84546486
67	MP0005319_abnormal_enzyme/_coenzyme	0.84524876
68	MP0003136_yellow_coat_color	0.81882319
69	MP0005389_reproductive_system_phenotype	0.79495438
70	MP0009643_abnormal_urine_homeostasis	0.77633327
71	MP0001324_abnormal_eye_pigmentation	0.76830150
72	MP0001485_abnormal_pinna_reflex	0.76231859
73	MP0005410_abnormal_fertilization	0.75812235
74	MP0010386_abnormal_urinary_bladder	0.74074775
75	MP0008058_abnormal_DNA_repair	0.73873646
76	MP0008995_early_reproductive_senescence	0.73830330
77	MP0000631_abnormal_neuroendocrine_gland	0.72586583
78	MP0002557_abnormal_social/conspecific_i	0.71182982
79	MP0008775_abnormal_heart_ventricle	0.70979798
80	MP0000569_abnormal_digit_pigmentation	0.70604151
81	MP0005395_other_phenotype	0.70287972
82	MP0002064_seizures	0.69715834
83	MP0000647_abnormal_sebaceous_gland	0.69546514
84	MP0001919_abnormal_reproductive_system	0.69255796
85	MP0002733_abnormal_thermal_nociception	0.69133678
86	MP0005167_abnormal_blood-brain_barrier	0.69079826
87	MP0002234_abnormal_pharynx_morphology	0.67918206
88	MP0005174_abnormal_tail_pigmentation	0.67394278
89	MP0002282_abnormal_trachea_morphology	0.67071005
90	MP0004215_abnormal_myocardial_fiber	0.66669998
91	MP0003121_genomic_imprinting	0.66622822
92	MP0005195_abnormal_posterior_eye	0.66618225
93	MP0000230_abnormal_systemic_arterial	0.65359264
94	MP0005386_behavior/neurological_phenoty	0.64097627
95	MP0004924_abnormal_behavior	0.64097627
96	MP0002090_abnormal_vision	0.63840464
97	MP0001905_abnormal_dopamine_level	0.63333408
98	MP0000639_abnormal_adrenal_gland	0.63184499
99	MP0005408_hypopigmentation	0.62730146
100	MP0003122_maternal_imprinting	0.62249389

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	4.35343713
2	Hyperglycinemia (HP:0002154)	3.74543450
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.68178034
4	Delayed CNS myelination (HP:0002188)	3.65975976
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.62668664
6	Pancreatic cysts (HP:0001737)	3.51820615
7	Complement deficiency (HP:0004431)	3.21930788
8	Hypobetalipoproteinemia (HP:0003563)	3.19986174
9	Pancreatic fibrosis (HP:0100732)	3.13418666
10	Congenital stationary night blindness (HP:0007642)	3.03174927
11	True hermaphroditism (HP:0010459)	3.01586547
12	Acute encephalopathy (HP:0006846)	3.01192146
13	Deep venous thrombosis (HP:0002625)	2.99509496
14	Abnormality of glycine metabolism (HP:0010895)	2.98113205
15	Abnormality of serine family amino acid metabolism (HP:0010894)	2.98113205
16	Renal cortical cysts (HP:0000803)	2.81531605
17	Hyperglycinuria (HP:0003108)	2.79951756
18	Nephronophthisis (HP:0000090)	2.79943230
19	Generalized aminoaciduria (HP:0002909)	2.78740645
20	Acute necrotizing encephalopathy (HP:0006965)	2.78392937
21	Abnormality of the renal cortex (HP:0011035)	2.78066249
22	Abnormality of midbrain morphology (HP:0002418)	2.76987154
23	Molar tooth sign on MRI (HP:0002419)	2.76987154
24	Hypothermia (HP:0002045)	2.76038153
25	Abnormality of serum amino acid levels (HP:0003112)	2.72831974
26	Hepatic necrosis (HP:0002605)	2.72115174
27	Joint hemorrhage (HP:0005261)	2.71235274
28	Ketosis (HP:0001946)	2.68160769
29	Increased CSF lactate (HP:0002490)	2.65347533
30	Mitochondrial inheritance (HP:0001427)	2.64398711
31	Abnormal biliary tract physiology (HP:0012439)	2.63911997
32	Bile duct proliferation (HP:0001408)	2.63911997
33	Glycosuria (HP:0003076)	2.59102784
34	Abnormality of urine glucose concentration (HP:0011016)	2.59102784
35	Conjugated hyperbilirubinemia (HP:0002908)	2.57702025
36	Hepatocellular necrosis (HP:0001404)	2.55883610
37	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.54905268
38	Progressive macrocephaly (HP:0004481)	2.54253662
39	Abnormality of pyrimidine metabolism (HP:0004353)	2.53420126
40	Decreased central vision (HP:0007663)	2.52140390
41	Type II lissencephaly (HP:0007260)	2.51394861
42	Cerebral edema (HP:0002181)	2.48414369
43	Abolished electroretinogram (ERG) (HP:0000550)	2.45199346
44	Lethargy (HP:0001254)	2.44858171
45	Methylmalonic acidemia (HP:0002912)	2.40731965
46	Abnormality of methionine metabolism (HP:0010901)	2.39735831
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39009587
48	Fair hair (HP:0002286)	2.37812652
49	Abnormality of the renal medulla (HP:0100957)	2.36154578
50	Xanthomatosis (HP:0000991)	2.34892044
51	Hyperlipoproteinemia (HP:0010980)	2.29579160
52	Medial flaring of the eyebrow (HP:0010747)	2.28816407
53	Attenuation of retinal blood vessels (HP:0007843)	2.25701323
54	Pendular nystagmus (HP:0012043)	2.20757428
55	Methylmalonic aciduria (HP:0012120)	2.19988537
56	Abnormality of alanine metabolism (HP:0010916)	2.17791062
57	Hyperalaninemia (HP:0003348)	2.17791062
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17791062
59	Spontaneous abortion (HP:0005268)	2.17677010
60	Systemic lupus erythematosus (HP:0002725)	2.14088702
61	Increased serum lactate (HP:0002151)	2.12419830
62	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.12236170
63	Intrahepatic cholestasis (HP:0001406)	2.09360583
64	Cystic liver disease (HP:0006706)	2.09194764
65	Ketoacidosis (HP:0001993)	2.06722528
66	Abnormal rod and cone electroretinograms (HP:0008323)	2.05339062
67	Metabolic acidosis (HP:0001942)	2.00027278
68	Hypomagnesemia (HP:0002917)	1.99827111
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98685216
70	Optic disc pallor (HP:0000543)	1.98534423
71	Large for gestational age (HP:0001520)	1.98259559
72	Sclerocornea (HP:0000647)	1.97093585
73	Abnormal drinking behavior (HP:0030082)	1.95518994
74	Polydipsia (HP:0001959)	1.95518994
75	Abnormality of complement system (HP:0005339)	1.94534411
76	Chronic hepatic failure (HP:0100626)	1.93744832
77	Hyperammonemia (HP:0001987)	1.92507146
78	Hyperventilation (HP:0002883)	1.91779783
79	Lactic acidosis (HP:0003128)	1.91327896
80	Cerebral palsy (HP:0100021)	1.91250474
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.87352614
82	Lipid accumulation in hepatocytes (HP:0006561)	1.84397736
83	Arthropathy (HP:0003040)	1.83996972
84	Male pseudohermaphroditism (HP:0000037)	1.82615266
85	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.81911729
86	Hypoglycemic coma (HP:0001325)	1.78879765
87	CNS demyelination (HP:0007305)	1.78476712
88	Progressive inability to walk (HP:0002505)	1.78003642
89	3-Methylglutaconic aciduria (HP:0003535)	1.75538181
90	Hyperphosphaturia (HP:0003109)	1.74599473
91	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.73735560
92	Dicarboxylic aciduria (HP:0003215)	1.73735560
93	Gait imbalance (HP:0002141)	1.72496574
94	Keratoconus (HP:0000563)	1.72487628
95	Increased corneal curvature (HP:0100692)	1.72487628
96	Stomach cancer (HP:0012126)	1.72268949
97	Inability to walk (HP:0002540)	1.71390466
98	Congenital hepatic fibrosis (HP:0002612)	1.69646960
99	Generalized hypopigmentation of hair (HP:0011358)	1.69614352
100	Congenital primary aphakia (HP:0007707)	1.69421269

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.44788459
2	MAP4K2	3.25884080
3	TAOK3	3.25545234
4	WNK3	2.76139153
5	NUAK1	2.75251747
6	ADRBK2	2.60831727
7	WNK4	2.60210221
8	MAP3K12	2.52027612
9	ZAK	2.46870310
10	GRK1	2.33993034
11	BMPR1B	2.27487240
12	BCKDK	1.96282844
13	STK39	1.85443717
14	TLK1	1.81506985
15	TRIM28	1.73053084
16	TXK	1.65933185
17	PINK1	1.64831649
18	VRK2	1.61467621
19	OXSR1	1.58488449
20	INSRR	1.51991465
21	MAP3K4	1.49619829
22	CASK	1.48328745
23	MAPK13	1.47328925
24	EIF2AK3	1.38089908
25	TIE1	1.37733096
26	ACVR1B	1.28178341
27	TNIK	1.24457204
28	MUSK	1.24311106
29	STK16	1.22834734
30	MST4	1.21447974
31	ERBB3	1.10258337
32	VRK1	1.09941262
33	PRKCG	1.06739796
34	PHKG2	1.05704966
35	PHKG1	1.05704966
36	DYRK2	1.04167900
37	CSNK1G3	1.00222985
38	DAPK2	1.00106774
39	EIF2AK1	0.98364102
40	PLK2	0.98187011
41	CSNK1G1	0.93480881
42	PAK3	0.91843740
43	CSNK1G2	0.90228793
44	MKNK2	0.88475058
45	PRKCE	0.88469981
46	MAP2K7	0.87924952
47	PLK3	0.83201130
48	PDK2	0.82024317
49	EPHA4	0.80979361
50	MAP2K4	0.80102045
51	BRSK2	0.79681812
52	IKBKB	0.73514142
53	FGFR2	0.70872342
54	CSNK1A1L	0.68336808
55	PIK3CA	0.66628712
56	BUB1	0.64418623
57	TGFBR1	0.63102416
58	ADRBK1	0.62945435
59	KIT	0.61162374
60	NME1	0.61015927
61	BCR	0.60822123
62	PRKCQ	0.59726304
63	MAPKAPK3	0.57734811
64	MARK1	0.57422687
65	PLK4	0.57278660
66	EIF2AK2	0.56375115
67	PRKACA	0.54913418
68	GRK7	0.54424596
69	SRPK1	0.53701156
70	FER	0.52854049
71	CSNK1A1	0.51425972
72	TEC	0.51093358
73	NEK1	0.50458658
74	PBK	0.49789323
75	CCNB1	0.49702953
76	DAPK1	0.48815021
77	MAP2K6	0.48174470
78	GRK5	0.47556438
79	WEE1	0.45287940
80	PRKCI	0.44863556
81	PLK1	0.43643646
82	PRKCA	0.43286098
83	IGF1R	0.42856961
84	PRKACG	0.41399969
85	CSNK1D	0.41368436
86	MAP2K2	0.41295812
87	ATR	0.41033286
88	CAMKK2	0.40812361
89	RPS6KA5	0.40534064
90	MKNK1	0.39120176
91	TNK2	0.39031379
92	GRK6	0.38294004
93	PRKG1	0.38052206
94	NTRK3	0.37873811
95	PIK3CG	0.37721366
96	CSNK2A1	0.37512598
97	PRKAA2	0.37117304
98	STK38L	0.35645873
99	PKN1	0.35032969
100	LIMK1	0.34844842

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.46429836
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.12014016
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.74910891
4	Retinol metabolism_Homo sapiens_hsa00830	2.69429589
5	Butanoate metabolism_Homo sapiens_hsa00650	2.48272290
6	Chemical carcinogenesis_Homo sapiens_hsa05204	2.46439729
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.42518962
8	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.36134890
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.33026064
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31806650
11	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.28838878
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.25223128
13	Complement and coagulation cascades_Homo sapiens_hsa04610	2.19960446
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19361680
15	Tryptophan metabolism_Homo sapiens_hsa00380	2.16058832
16	Linoleic acid metabolism_Homo sapiens_hsa00591	2.12120427
17	Fatty acid degradation_Homo sapiens_hsa00071	2.07196053
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.00974490
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.98660419
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.88750090
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82601012
22	Peroxisome_Homo sapiens_hsa04146	1.68591734
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62005871
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.60296141
25	Tyrosine metabolism_Homo sapiens_hsa00350	1.52449269
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.49444585
27	Propanoate metabolism_Homo sapiens_hsa00640	1.48790437
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.46143148
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36257805
30	Protein export_Homo sapiens_hsa03060	1.35012047
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.33829353
32	Histidine metabolism_Homo sapiens_hsa00340	1.32860026
33	One carbon pool by folate_Homo sapiens_hsa00670	1.31823685
34	Phototransduction_Homo sapiens_hsa04744	1.30512976
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.30072211
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.25969375
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.24667263
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24168579
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.22346536
40	Phenylalanine metabolism_Homo sapiens_hsa00360	1.18300202
41	Parkinsons disease_Homo sapiens_hsa05012	1.17726829
42	Proteasome_Homo sapiens_hsa03050	1.16417602
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.15044182
44	Sulfur metabolism_Homo sapiens_hsa00920	1.14036392
45	RNA polymerase_Homo sapiens_hsa03020	1.09398674
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.06822247
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.00033653
48	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.95983416
49	Homologous recombination_Homo sapiens_hsa03440	0.94692691
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.90209915
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87599024
52	ABC transporters_Homo sapiens_hsa02010	0.85797976
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.84410149
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.83471349
55	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.82907399
56	Bile secretion_Homo sapiens_hsa04976	0.81773643
57	Fatty acid elongation_Homo sapiens_hsa00062	0.81652937
58	Metabolic pathways_Homo sapiens_hsa01100	0.81623583
59	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.81119343
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78397984
61	Basal transcription factors_Homo sapiens_hsa03022	0.77942228
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.75726343
63	PPAR signaling pathway_Homo sapiens_hsa03320	0.75449724
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.74418355
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72751774
66	RNA degradation_Homo sapiens_hsa03018	0.72207523
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71404799
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.63014982
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.62980498
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60685097
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60394126
72	Huntingtons disease_Homo sapiens_hsa05016	0.60369102
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.58572468
74	Nicotine addiction_Homo sapiens_hsa05033	0.58000250
75	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56931301
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.56405660
77	Alzheimers disease_Homo sapiens_hsa05010	0.55876385
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55706084
79	Glutathione metabolism_Homo sapiens_hsa00480	0.48167809
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46870023
81	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46064722
82	Folate biosynthesis_Homo sapiens_hsa00790	0.44273715
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44167946
84	Asthma_Homo sapiens_hsa05310	0.41071275
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.40854420
86	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40434942
87	Regulation of autophagy_Homo sapiens_hsa04140	0.39660612
88	Serotonergic synapse_Homo sapiens_hsa04726	0.38679181
89	Purine metabolism_Homo sapiens_hsa00230	0.36715418
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.36636294
91	Mineral absorption_Homo sapiens_hsa04978	0.35823609
92	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.35474261
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33438230
94	Sulfur relay system_Homo sapiens_hsa04122	0.32319497
95	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.32271315
96	Carbon metabolism_Homo sapiens_hsa01200	0.31967271
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29565003
98	Taste transduction_Homo sapiens_hsa04742	0.29443953
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28963669
100	Olfactory transduction_Homo sapiens_hsa04740	0.28517063

APOC1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »