APOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.93216971
2epoxygenase P450 pathway (GO:0019373)7.45914338
3omega-hydroxylase P450 pathway (GO:0097267)7.05759404
4* triglyceride-rich lipoprotein particle remodeling (GO:0034370)7.00652198
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.82047988
6L-phenylalanine catabolic process (GO:0006559)6.82047988
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.57888589
8L-phenylalanine metabolic process (GO:0006558)6.57888589
9high-density lipoprotein particle remodeling (GO:0034375)6.34869404
10aromatic amino acid family catabolic process (GO:0009074)6.08517581
11regulation of cholesterol esterification (GO:0010872)6.00426793
12negative regulation of fibrinolysis (GO:0051918)5.72400422
13urea cycle (GO:0000050)5.65234642
14urea metabolic process (GO:0019627)5.65234642
15glyoxylate metabolic process (GO:0046487)5.53150998
16* reverse cholesterol transport (GO:0043691)5.49058243
17alpha-linolenic acid metabolic process (GO:0036109)5.46547270
18tryptophan catabolic process (GO:0006569)5.44862004
19indole-containing compound catabolic process (GO:0042436)5.44862004
20indolalkylamine catabolic process (GO:0046218)5.44862004
21kynurenine metabolic process (GO:0070189)5.44188588
22regulation of fibrinolysis (GO:0051917)5.41871363
23bile acid biosynthetic process (GO:0006699)5.35066023
24* phospholipid efflux (GO:0033700)5.30924366
25peptidyl-glutamic acid carboxylation (GO:0017187)5.27207199
26protein carboxylation (GO:0018214)5.27207199
27* plasma lipoprotein particle remodeling (GO:0034369)5.27145026
28* protein-lipid complex remodeling (GO:0034368)5.27145026
29* macromolecular complex remodeling (GO:0034367)5.27145026
30drug metabolic process (GO:0017144)5.26150178
31nitrogen cycle metabolic process (GO:0071941)5.18126841
32tryptophan metabolic process (GO:0006568)5.16570975
33* regulation of triglyceride catabolic process (GO:0010896)5.13261513
34negative regulation of hemostasis (GO:1900047)5.10004963
35negative regulation of blood coagulation (GO:0030195)5.10004963
36plasma lipoprotein particle assembly (GO:0034377)5.07646958
37regulation of protein activation cascade (GO:2000257)5.04096164
38complement activation, alternative pathway (GO:0006957)4.94073067
39cysteine metabolic process (GO:0006534)4.92644684
40* cholesterol efflux (GO:0033344)4.90791224
41sulfur amino acid catabolic process (GO:0000098)4.88583165
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83834983
43oxidative demethylation (GO:0070989)4.82818556
44* plasma lipoprotein particle clearance (GO:0034381)4.74518801
45serine family amino acid catabolic process (GO:0009071)4.67268905
46phenylpropanoid metabolic process (GO:0009698)4.65688666
47negative regulation of coagulation (GO:0050819)4.65585566
48regulation of complement activation (GO:0030449)4.65338833
49complement activation (GO:0006956)4.63955798
50bile acid metabolic process (GO:0008206)4.63089540
51* acylglycerol homeostasis (GO:0055090)4.61296101
52* triglyceride homeostasis (GO:0070328)4.61296101
53protein-lipid complex assembly (GO:0065005)4.58862323
54positive regulation of hemostasis (GO:1900048)4.58156498
55positive regulation of blood coagulation (GO:0030194)4.58156498
56* negative regulation of cholesterol transport (GO:0032375)4.50653415
57* negative regulation of sterol transport (GO:0032372)4.50653415
58negative regulation of wound healing (GO:0061045)4.49498639
59ethanol metabolic process (GO:0006067)4.48073246
60aromatic amino acid family metabolic process (GO:0009072)4.43999500
61amino-acid betaine metabolic process (GO:0006577)4.42999479
62intestinal cholesterol absorption (GO:0030299)4.38362609
63very-low-density lipoprotein particle assembly (GO:0034379)4.37021931
64regulation of humoral immune response (GO:0002920)4.35851423
65homocysteine metabolic process (GO:0050667)4.34722341
66tyrosine metabolic process (GO:0006570)4.32883863
67positive regulation of coagulation (GO:0050820)4.24712731
68cellular ketone body metabolic process (GO:0046950)4.22898626
69lysine metabolic process (GO:0006553)4.22387978
70lysine catabolic process (GO:0006554)4.22387978
71low-density lipoprotein particle remodeling (GO:0034374)4.17904081
72alpha-amino acid catabolic process (GO:1901606)4.17086770
73* positive regulation of lipoprotein lipase activity (GO:0051006)4.13173685
74* positive regulation of triglyceride lipase activity (GO:0061365)4.13173685
75* plasma lipoprotein particle organization (GO:0071827)4.12890842
76drug catabolic process (GO:0042737)4.11146739
77phospholipid homeostasis (GO:0055091)4.09786179
78bile acid and bile salt transport (GO:0015721)4.09714244
79* cholesterol homeostasis (GO:0042632)4.08800127
80negative regulation of protein activation cascade (GO:2000258)4.06674540
81* lipoprotein metabolic process (GO:0042157)4.06358198
82glycine metabolic process (GO:0006544)4.03581741
83* sterol homeostasis (GO:0055092)4.02633652
84cellular glucuronidation (GO:0052695)3.98732438
85fat-soluble vitamin biosynthetic process (GO:0042362)3.98516998
86* positive regulation of lipid catabolic process (GO:0050996)3.98357973
87fibrinolysis (GO:0042730)3.97798130
88arginine metabolic process (GO:0006525)3.96592730
89glutamate metabolic process (GO:0006536)3.92253209
90* protein-lipid complex subunit organization (GO:0071825)3.89937135
91aldehyde catabolic process (GO:0046185)3.88473520
92indolalkylamine metabolic process (GO:0006586)3.86194759
93negative regulation of lipase activity (GO:0060192)3.85551378
94serine family amino acid metabolic process (GO:0009069)3.85324827
95blood coagulation, intrinsic pathway (GO:0007597)3.85237535
96cellular amino acid catabolic process (GO:0009063)3.84626895
97imidazole-containing compound metabolic process (GO:0052803)3.83499461
98regulation of apoptotic cell clearance (GO:2000425)3.82961390
99flavonoid metabolic process (GO:0009812)3.80099127
100serine family amino acid biosynthetic process (GO:0009070)3.79668401
101amine catabolic process (GO:0009310)3.77736803
102cellular biogenic amine catabolic process (GO:0042402)3.77736803
103alkaloid metabolic process (GO:0009820)3.76313775
104cellular modified amino acid catabolic process (GO:0042219)3.76027763
105dicarboxylic acid biosynthetic process (GO:0043650)3.75909617
106benzene-containing compound metabolic process (GO:0042537)3.74014502
107coenzyme catabolic process (GO:0009109)3.72625134
108S-adenosylmethionine metabolic process (GO:0046500)3.72310067
109heme transport (GO:0015886)3.69507538
110acute inflammatory response (GO:0002526)3.65585927
111ketone body metabolic process (GO:1902224)3.64511736
112cytolysis (GO:0019835)3.61861041
113acute-phase response (GO:0006953)3.60290105
114intestinal absorption (GO:0050892)3.60025237
115opsonization (GO:0008228)3.59946244
116regulation of cholesterol homeostasis (GO:2000188)3.59555314
117protein activation cascade (GO:0072376)3.58272553
118cofactor catabolic process (GO:0051187)3.57754133
119glucuronate metabolic process (GO:0019585)3.56439986
120uronic acid metabolic process (GO:0006063)3.56439986
121ethanol oxidation (GO:0006069)3.55766532
122regulation of bile acid biosynthetic process (GO:0070857)3.55598211
123regulation of plasminogen activation (GO:0010755)3.49887789
124complement activation, classical pathway (GO:0006958)3.47876792
125positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.44367407
126proline metabolic process (GO:0006560)3.39770124
127hormone catabolic process (GO:0042447)3.38178137
128negative regulation of complement activation (GO:0045916)3.37928417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.07326531
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.03744400
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.77052989
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.32430630
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00370929
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.99967366
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.90424497
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.81575267
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80885416
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.36050062
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6265884
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91327320
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88957443
14GATA1_22025678_ChIP-Seq_K562_Human1.67045545
15CLOCK_20551151_ChIP-Seq_293T_Human1.58330424
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.58314355
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.57493421
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54436610
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48110440
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.45746005
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45619810
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45104395
23HTT_18923047_ChIP-ChIP_STHdh_Human1.34634593
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20893855
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20596030
26RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15159284
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11797563
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09402345
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07232614
30GATA4_25053715_ChIP-Seq_YYC3_Human1.06917615
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03376819
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01322116
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01278810
34ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93689837
35ELF1_20517297_ChIP-Seq_JURKAT_Human0.93546956
36CDX2_20551321_ChIP-Seq_CACO-2_Human0.92312148
37ESR1_20079471_ChIP-ChIP_T-47D_Human0.91079307
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90045936
39RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89921507
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87119978
41* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85716957
42SPI1_20517297_ChIP-Seq_HL60_Human0.84324348
43DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82854770
44SA1_27219007_Chip-Seq_Bcells_Human0.82546149
45SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81247573
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80754047
47KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80486484
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80043097
49RARA_24833708_ChIP-Seq_LIVER_Mouse0.79207118
50SOX2_21211035_ChIP-Seq_LN229_Human0.78670864
51RAC3_21632823_ChIP-Seq_H3396_Human0.78463455
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78341814
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78111949
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77401812
55ERG_21242973_ChIP-ChIP_JURKAT_Human0.77253471
56E2F1_20622854_ChIP-Seq_HELA_Human0.76412374
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75592436
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74647009
59SMC4_20622854_ChIP-Seq_HELA_Human0.73832711
60* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73595273
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72213553
62AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71031339
63EGR1_19032775_ChIP-ChIP_M12_Human0.70322121
64CTCF_20526341_ChIP-Seq_ESCs_Human0.69482659
65IRF8_21731497_ChIP-ChIP_J774_Mouse0.69067341
66BP1_19119308_ChIP-ChIP_Hs578T_Human0.68685564
67ESR2_21235772_ChIP-Seq_MCF-7_Human0.67521702
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.67155363
69IRF8_27001747_Chip-Seq_BMDM_Mouse0.66934454
70TP63_17297297_ChIP-ChIP_HaCaT_Human0.66850723
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66053879
72GATA6_25053715_ChIP-Seq_YYC3_Human0.65822666
73STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65052589
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64812220
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.64537587
76AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63681684
77LXR_22292898_ChIP-Seq_THP-1_Human0.63420594
78* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63401261
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.63242896
80VDR_21846776_ChIP-Seq_THP-1_Human0.63226110
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.62976611
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62747719
83GATA1_19941826_ChIP-Seq_K562_Human0.62661133
84CEBPB_22108803_ChIP-Seq_LS180_Human0.62198619
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.61982018
86JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.61859554
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.61777498
88GATA3_21867929_ChIP-Seq_CD8_Mouse0.61759124
89* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61730056
90GATA2_19941826_ChIP-Seq_K562_Human0.61643991
91CTCF_27219007_Chip-Seq_Bcells_Human0.60711178
92P68_20966046_ChIP-Seq_HELA_Human0.60507625
93P300_27268052_Chip-Seq_Bcells_Human0.60354176
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60196595
95PHF8_20622854_ChIP-Seq_HELA_Human0.59832255
96ZNF263_19887448_ChIP-Seq_K562_Human0.59770929
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.59100939
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.58259900
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57938132
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57938132
101P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.57832003
102CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.57434563
103* SOX2_20726797_ChIP-Seq_SW620_Human0.56406742
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.54922947
105BRD4_27068464_Chip-Seq_AML-cells_Mouse0.54486615
106TAF2_19829295_ChIP-Seq_ESCs_Human0.53133922
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.52944703
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52162934
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51925391
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51658621
111* AR_20517297_ChIP-Seq_VCAP_Human0.51644486
112* MYC_19915707_ChIP-ChIP_AK7_Human0.51101696
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49205500
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.49061638
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.48213826
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48003158
117STAT1_17558387_ChIP-Seq_HELA_Human0.47782663
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.47621422
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46096657
120BCOR_27268052_Chip-Seq_Bcells_Human0.45882703
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.45019283
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44984737
123P53_21459846_ChIP-Seq_SAOS-2_Human0.43633327
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.43565405
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43462571
126CBP_21632823_ChIP-Seq_H3396_Human0.43115971
127* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42515831
128CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.42456066
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.41560078
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.40139868
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.39874285
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39713882
133BCL6_27268052_Chip-Seq_Bcells_Human0.39131369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.90228201
2MP0005360_urolithiasis7.81230981
3MP0005085_abnormal_gallbladder_physiolo5.96498495
4MP0005365_abnormal_bile_salt5.69544754
5MP0008875_abnormal_xenobiotic_pharmacok4.71262760
6MP0009840_abnormal_foam_cell4.16421117
7MP0003252_abnormal_bile_duct3.87348553
8MP0003806_abnormal_nucleotide_metabolis3.85774426
9MP0010329_abnormal_lipoprotein_level3.75296998
10MP0001666_abnormal_nutrient_absorption3.10886461
11MP0003191_abnormal_cellular_cholesterol2.79882981
12MP0005083_abnormal_biliary_tract2.76117406
13MP0005332_abnormal_amino_acid2.61263673
14MP0003195_calcinosis2.44509971
15MP0004019_abnormal_vitamin_homeostasis2.27488781
16MP0000609_abnormal_liver_physiology2.17487200
17MP0002118_abnormal_lipid_homeostasis2.05943795
18MP0002138_abnormal_hepatobiliary_system1.93434988
19MP0009697_abnormal_copulation1.82905609
20MP0005319_abnormal_enzyme/_coenzyme1.79102889
21MP0001764_abnormal_homeostasis1.66459383
22MP0003868_abnormal_feces_composition1.61760006
23MP0005451_abnormal_body_composition1.54922461
24MP0005584_abnormal_enzyme/coenzyme_acti1.51474004
25MP0003656_abnormal_erythrocyte_physiolo1.46366443
26MP0003011_delayed_dark_adaptation1.39284742
27MP0000604_amyloidosis1.34716194
28MP0002254_reproductive_system_inflammat1.29733545
29MP0009643_abnormal_urine_homeostasis1.28597442
30MP0003186_abnormal_redox_activity1.26437599
31MP0009764_decreased_sensitivity_to1.21312249
32MP0003705_abnormal_hypodermis_morpholog1.18301729
33MP0000598_abnormal_liver_morphology1.16699683
34MP0003172_abnormal_lysosome_physiology1.07291831
35MP0005084_abnormal_gallbladder_morpholo1.06667816
36MP0008469_abnormal_protein_level1.05598107
37MP0009763_increased_sensitivity_to1.05027109
38MP0002132_abnormal_respiratory_system0.98865045
39MP0005636_abnormal_mineral_homeostasis0.95104593
40MP0009642_abnormal_blood_homeostasis0.91516400
41MP0003879_abnormal_hair_cell0.91233140
42MP0001915_intracranial_hemorrhage0.89061685
43MP0005647_abnormal_sex_gland0.89017640
44MP0003436_decreased_susceptibility_to0.88424804
45MP0005408_hypopigmentation0.85483118
46MP0005376_homeostasis/metabolism_phenot0.85417300
47MP0005464_abnormal_platelet_physiology0.85090023
48MP0009765_abnormal_xenobiotic_induced0.79778055
49MP0010368_abnormal_lymphatic_system0.78670235
50MP0002876_abnormal_thyroid_physiology0.76582629
51MP0002078_abnormal_glucose_homeostasis0.74300316
52MP0006036_abnormal_mitochondrial_physio0.72363363
53MP0003690_abnormal_glial_cell0.71878250
54MP0009053_abnormal_anal_canal0.69433386
55MP0005448_abnormal_energy_balance0.68348938
56MP0002971_abnormal_brown_adipose0.67938714
57MP0003724_increased_susceptibility_to0.67335431
58MP0005334_abnormal_fat_pad0.67325242
59MP0005266_abnormal_metabolism0.64686757
60MP0005535_abnormal_body_temperature0.61860318
61MP0004264_abnormal_extraembryonic_tissu0.61587046
62MP0003718_maternal_effect0.61369613
63MP0002168_other_aberrant_phenotype0.61126869
64MP0006082_CNS_inflammation0.60521337
65MP0003329_amyloid_beta_deposits0.60458082
66MP0001756_abnormal_urination0.59866680
67MP0003075_altered_response_to0.57896050
68MP0002136_abnormal_kidney_physiology0.57557524
69MP0005397_hematopoietic_system_phenotyp0.53471398
70MP0001545_abnormal_hematopoietic_system0.53471398
71MP0005166_decreased_susceptibility_to0.53305148
72MP0000685_abnormal_immune_system0.53035206
73MP0001845_abnormal_inflammatory_respons0.52682593
74MP0005058_abnormal_lysosome_morphology0.52409744
75MP0005220_abnormal_exocrine_pancreas0.52094382
76MP0005670_abnormal_white_adipose0.51846250
77MP0000639_abnormal_adrenal_gland0.51440913
78MP0005023_abnormal_wound_healing0.51208781
79MP0002822_catalepsy0.51150877
80MP0002282_abnormal_trachea_morphology0.51101988
81MP0005395_other_phenotype0.50575143
82MP0008873_increased_physiological_sensi0.50186741
83MP0004130_abnormal_muscle_cell0.49546617
84MP0009785_altered_susceptibility_to0.49047603
85MP0000858_altered_metastatic_potential0.48867648
86MP0003638_abnormal_response/metabolism_0.48531440
87MP0000920_abnormal_myelination0.48141274
88MP0002089_abnormal_postnatal_growth/wei0.47983998
89MP0004883_abnormal_blood_vessel0.46376878
90MP0005167_abnormal_blood-brain_barrier0.46131404
91MP0002419_abnormal_innate_immunity0.45056551
92MP0004782_abnormal_surfactant_physiolog0.44276571
93MP0000249_abnormal_blood_vessel0.44173900
94MP0006035_abnormal_mitochondrial_morpho0.42909863
95MP0001661_extended_life_span0.42255450
96MP0003303_peritoneal_inflammation0.41916634
97MP0005025_abnormal_response_to0.41864661
98MP0004147_increased_porphyrin_level0.41770776
99MP0005164_abnormal_response_to0.41569924
100MP0002796_impaired_skin_barrier0.41011266
101MP0009115_abnormal_fat_cell0.40901773
102MP0000343_altered_response_to0.40482166
103MP0001853_heart_inflammation0.39972785
104MP0004947_skin_inflammation0.38118096
105MP0002928_abnormal_bile_duct0.37791121
106MP0003953_abnormal_hormone_level0.36883193
107MP0008872_abnormal_physiological_respon0.36877122
108MP0002249_abnormal_larynx_morphology0.35621896
109MP0010234_abnormal_vibrissa_follicle0.34372114
110MP0001881_abnormal_mammary_gland0.33885687
111MP0008874_decreased_physiological_sensi0.33141572
112MP0003300_gastrointestinal_ulcer0.33101707
113MP0001243_abnormal_dermal_layer0.32934356
114MP0005248_abnormal_Harderian_gland0.32642817
115MP0002148_abnormal_hypersensitivity_rea0.32284159
116MP0002998_abnormal_bone_remodeling0.31970344
117MP0005666_abnormal_adipose_tissue0.31871765
118MP0003632_abnormal_nervous_system0.31068474
119MP0001533_abnormal_skeleton_physiology0.30755392
120MP0001986_abnormal_taste_sensitivity0.30720309
121MP0005377_hearing/vestibular/ear_phenot0.29235917
122MP0003878_abnormal_ear_physiology0.29235917
123MP0002090_abnormal_vision0.28985312

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.08295991
2Hypobetalipoproteinemia (HP:0003563)6.89199074
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.67258181
4Intrahepatic cholestasis (HP:0001406)6.63178730
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.30081041
6Prolonged partial thromboplastin time (HP:0003645)6.28812482
7* Xanthomatosis (HP:0000991)5.87723662
8Hypolipoproteinemia (HP:0010981)5.19509755
9Hyperlipoproteinemia (HP:0010980)5.17102837
10Complement deficiency (HP:0004431)5.03677320
11Joint hemorrhage (HP:0005261)4.87871594
12Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.66473541
13Abnormality of the common coagulation pathway (HP:0010990)4.52842101
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.51866695
15Hyperammonemia (HP:0001987)4.41377249
16Hypoalphalipoproteinemia (HP:0003233)4.39684258
17Epidermoid cyst (HP:0200040)4.32868562
18Fat malabsorption (HP:0002630)4.14332201
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.00206428
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95831765
21Hyperglycinemia (HP:0002154)3.94640460
22Hyperglycinuria (HP:0003108)3.92956515
23Hypoglycemic coma (HP:0001325)3.92577226
24Ketosis (HP:0001946)3.89403013
25Hypercholesterolemia (HP:0003124)3.82670537
26Abnormality of methionine metabolism (HP:0010901)3.79893624
27Abnormality of glycine metabolism (HP:0010895)3.78983478
28Abnormality of serine family amino acid metabolism (HP:0010894)3.78983478
29Abnormality of complement system (HP:0005339)3.78274425
30Conjugated hyperbilirubinemia (HP:0002908)3.76955887
31Abnormality of pyrimidine metabolism (HP:0004353)3.73133296
32Abnormality of the intrinsic pathway (HP:0010989)3.59922599
33Acanthocytosis (HP:0001927)3.40594396
34Hyperbilirubinemia (HP:0002904)3.32059257
35Purpura (HP:0000979)3.30451039
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24811198
37Abnormality of fatty-acid metabolism (HP:0004359)3.21705499
38Systemic lupus erythematosus (HP:0002725)3.16848814
39Spontaneous abortion (HP:0005268)3.11228663
40Abnormality of nucleobase metabolism (HP:0010932)3.04251194
41Hepatocellular carcinoma (HP:0001402)2.92315910
42Myocardial infarction (HP:0001658)2.84438654
43Hypochromic microcytic anemia (HP:0004840)2.84031907
44Steatorrhea (HP:0002570)2.82400801
45Glomerulonephritis (HP:0000099)2.81450058
46Recurrent gram-negative bacterial infections (HP:0005420)2.79894766
47Metabolic acidosis (HP:0001942)2.77653607
48Ketoacidosis (HP:0001993)2.75928493
49Amyloidosis (HP:0011034)2.75594309
50Abnormality of serum amino acid levels (HP:0003112)2.72539460
51Abnormality of purine metabolism (HP:0004352)2.69810144
52Delayed CNS myelination (HP:0002188)2.67872721
53Skin nodule (HP:0200036)2.65395191
54Malnutrition (HP:0004395)2.64582176
55Poikilocytosis (HP:0004447)2.61442865
56Hypoglycemic seizures (HP:0002173)2.56159092
57Pulmonary embolism (HP:0002204)2.55499254
58Cholecystitis (HP:0001082)2.52896793
59Abnormal gallbladder physiology (HP:0012438)2.52896793
60Gingival bleeding (HP:0000225)2.50536983
61Dicarboxylic aciduria (HP:0003215)2.46999693
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46999693
63Vascular calcification (HP:0004934)2.45324190
64Abnormal gallbladder morphology (HP:0012437)2.44945363
65Cholelithiasis (HP:0001081)2.44205732
66Lethargy (HP:0001254)2.42099114
67Abnormality of the Achilles tendon (HP:0005109)2.34907795
68Hydroxyprolinuria (HP:0003080)2.33612541
69Abnormality of proline metabolism (HP:0010907)2.33612541
70Esophageal varix (HP:0002040)2.27199806
71Irritability (HP:0000737)2.27075489
72Menorrhagia (HP:0000132)2.25323440
73Spastic diplegia (HP:0001264)2.24855509
74Mitral stenosis (HP:0001718)2.19108658
75Cerebral edema (HP:0002181)2.18286309
76Thrombophlebitis (HP:0004418)2.16439292
77Gout (HP:0001997)2.16054578
78Cardiovascular calcification (HP:0011915)2.15761838
79Abnormality of transition element cation homeostasis (HP:0011030)2.15425720
80Sensorimotor neuropathy (HP:0007141)2.15041695
81Increased serum ferritin (HP:0003281)2.14257936
82Abnormality of iron homeostasis (HP:0011031)2.12521811
83Late onset (HP:0003584)2.12379402
84Hemorrhage of the eye (HP:0011885)2.10740072
85Osteomalacia (HP:0002749)2.09255562
86Hypophosphatemic rickets (HP:0004912)2.08968781
87Reticulocytosis (HP:0001923)2.05129730
88Nausea (HP:0002018)2.05119097
89Hyperinsulinemic hypoglycemia (HP:0000825)2.04813816
90Nephritis (HP:0000123)2.03565036
91Reduced antithrombin III activity (HP:0001976)2.03107738
92Vomiting (HP:0002013)2.02846527
93Generalized aminoaciduria (HP:0002909)2.02630557
94Fair hair (HP:0002286)2.01715223
95Gangrene (HP:0100758)2.00426346
96Neonatal onset (HP:0003623)1.99693440
97* Pancreatitis (HP:0001733)1.98925600
98Abnormality of the gallbladder (HP:0005264)1.97721304
99Retinal atrophy (HP:0001105)1.97093194
100Abnormality of urine glucose concentration (HP:0011016)1.94419509
101Glycosuria (HP:0003076)1.94419509
102Arthropathy (HP:0003040)1.92959895
103Epistaxis (HP:0000421)1.92795037
104Enlarged kidneys (HP:0000105)1.92739078
105Opisthotonus (HP:0002179)1.90832882
106Brushfield spots (HP:0001088)1.89367790
107Impaired platelet aggregation (HP:0003540)1.85314861
108Abnormal platelet function (HP:0011869)1.85314861
109Rickets (HP:0002748)1.84677095
110Mucopolysacchariduria (HP:0008155)1.84561706
111Urinary glycosaminoglycan excretion (HP:0003541)1.84561706
112Proximal tubulopathy (HP:0000114)1.84399413
113Elevated alkaline phosphatase (HP:0003155)1.83510287
114Confusion (HP:0001289)1.83222484
115Abnormality of vitamin metabolism (HP:0100508)1.82933792
116Abnormal cartilage morphology (HP:0002763)1.82814268
117Ileus (HP:0002595)1.82510726
118Neonatal hypoglycemia (HP:0001998)1.81003599
119Abnormal enzyme/coenzyme activity (HP:0012379)1.77843609
120Joint swelling (HP:0001386)1.77601852
121Abnormality of polysaccharide metabolism (HP:0011012)1.77224196
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77224196
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77224196
124Hyperphosphaturia (HP:0003109)1.76649806
125Bifid scrotum (HP:0000048)1.73626188
126Hypophosphatemia (HP:0002148)1.73172434
127Abnormality of alkaline phosphatase activity (HP:0004379)1.72941089
128Pathologic fracture (HP:0002756)1.50495248
129Abnormal urine phosphate concentration (HP:0012599)1.50006088
130Increased mean platelet volume (HP:0011877)1.49567217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.23234469
2ERN14.70282878
3FGFR44.02427488
4SIK13.58114523
5MST1R3.10100212
6TAOK32.89821244
7INSRR2.39965166
8FRK2.39623897
9ERBB42.33306826
10TYK22.21067156
11GRK62.01143364
12ICK1.89892115
13PKN21.81416865
14MAPK111.78569787
15PTK61.75706061
16FLT31.74456568
17MAP2K41.73120991
18TBK11.68957875
19PIK3CG1.68451005
20MAP3K141.64426005
21IRAK31.62312739
22PBK1.61066295
23NEK91.56752678
24ABL21.55868980
25TRIB31.53807455
26CAMKK21.45686760
27LATS11.36025516
28MAP3K111.31009460
29KDR1.30513414
30DAPK21.28734952
31MAP3K101.27299574
32JAK21.27151846
33PIK3CA1.26282543
34MET1.20421353
35PRPF4B1.20144570
36EPHB11.18842054
37MAP2K31.18532421
38JAK11.17587060
39RIPK11.16067538
40MAP3K31.15875670
41CAMK1G1.02079919
42PRKCG1.00795596
43PRKAA21.00097680
44TNK20.98691802
45WNK40.97503755
46BLK0.96057931
47PINK10.95912109
48IKBKE0.95619185
49CSK0.95393115
50ERBB20.95225125
51NME20.95019775
52MAP3K70.92180890
53RIPK40.92063466
54CDK60.87384091
55MAPK40.84094877
56PDK20.84005525
57PRKCZ0.79486266
58CAMKK10.76655554
59MAP4K10.76438021
60MATK0.75923125
61DYRK1B0.75573472
62NTRK30.75213630
63PRKACG0.72321970
64BMX0.70230568
65MAP2K20.69150987
66EPHA30.68426622
67PTK20.67077971
68TXK0.66588929
69SYK0.66482045
70MAP2K60.66213864
71PDPK10.64026594
72MAP3K20.63189777
73GSK3A0.61354335
74PRKG10.61006904
75RET0.60679768
76FGFR20.60498441
77PIM20.59151850
78MAPK120.59065091
79CSF1R0.57446314
80STK38L0.57374847
81GRK70.56627919
82MAP3K50.55977151
83TGFBR20.55741001
84PRKG20.55481921
85CAMK1D0.55382829
86CDC42BPA0.54951687
87MAPKAPK30.54924231
88GRK10.54706485
89DDR20.54419206
90CAMK2G0.54315444
91EPHA20.53400035
92TAOK20.52742269
93PRKCQ0.51853788
94TESK20.50844476
95LCK0.50148476
96PRKACA0.49577392
97CAMK40.47974180
98MAP3K130.47896883
99ACVR1B0.47781626
100SIK20.46984671
101FGR0.46633870
102ARAF0.46286237
103FGFR30.45591168
104MAP3K10.45549033
105PDGFRA0.45364289
106MAP2K10.44957070
107SGK10.44487728
108PRKAA10.44089528
109SRC0.43462739
110CDK40.43413025
111CSNK1D0.43052236
112PDK10.41719002
113NUAK10.41718580
114TIE10.40734191
115IKBKB0.40707467
116SMG10.40495881
117FES0.40437817
118KSR20.39354388
119IGF1R0.38401665
120EGFR0.38218277
121CSNK2A10.35626061
122RPS6KA30.35138765
123AKT30.34778538
124ZAP700.34406198
125PRKCB0.34071844
126MAPK70.33532225
127STK100.33213514
128LYN0.32098999
129CHUK0.31990586
130SGK30.31136271
131PRKCD0.29354522
132STK30.28817281
133JAK30.28708157
134ABL10.28328190
135KIT0.27904173
136PRKCA0.27861371
137MAPK150.26991929
138PIM10.26868243
139IRAK40.26318704
140IRAK20.25159922
141MAP3K60.24654317

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.17715388
2Nitrogen metabolism_Homo sapiens_hsa009103.50249245
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31065222
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13310677
5Arginine biosynthesis_Homo sapiens_hsa002203.07611640
6Complement and coagulation cascades_Homo sapiens_hsa046102.82089855
7Tryptophan metabolism_Homo sapiens_hsa003802.58476755
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58149670
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54231593
10Fatty acid degradation_Homo sapiens_hsa000712.50606925
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43622934
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23650564
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22600317
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08560159
15Peroxisome_Homo sapiens_hsa041462.01454588
16Staphylococcus aureus infection_Homo sapiens_hsa051502.01280815
17Histidine metabolism_Homo sapiens_hsa003402.00184720
18Butanoate metabolism_Homo sapiens_hsa006501.99657925
19PPAR signaling pathway_Homo sapiens_hsa033201.96768554
20Fat digestion and absorption_Homo sapiens_hsa049751.96723270
21Chemical carcinogenesis_Homo sapiens_hsa052041.85714447
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84376776
23Fatty acid metabolism_Homo sapiens_hsa012121.77973655
24Caffeine metabolism_Homo sapiens_hsa002321.75753938
25Propanoate metabolism_Homo sapiens_hsa006401.75082650
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.72438740
27beta-Alanine metabolism_Homo sapiens_hsa004101.68683438
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.67743895
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62152945
30Retinol metabolism_Homo sapiens_hsa008301.59421655
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55219670
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53195814
33Bile secretion_Homo sapiens_hsa049761.51662287
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49735561
35Starch and sucrose metabolism_Homo sapiens_hsa005001.48706487
36Selenocompound metabolism_Homo sapiens_hsa004501.48198113
37Phenylalanine metabolism_Homo sapiens_hsa003601.46459149
38Vitamin digestion and absorption_Homo sapiens_hsa049771.44970534
39Folate biosynthesis_Homo sapiens_hsa007901.44185061
40Sulfur metabolism_Homo sapiens_hsa009201.38228729
41Pyruvate metabolism_Homo sapiens_hsa006201.31994006
42Tyrosine metabolism_Homo sapiens_hsa003501.30884188
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30222559
44Fatty acid elongation_Homo sapiens_hsa000621.29198110
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.19879649
46ABC transporters_Homo sapiens_hsa020101.19839013
47Steroid biosynthesis_Homo sapiens_hsa001001.19639460
48Biosynthesis of amino acids_Homo sapiens_hsa012301.17049659
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.15952381
50Carbon metabolism_Homo sapiens_hsa012001.14501099
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11293081
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08866205
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07784858
54Arginine and proline metabolism_Homo sapiens_hsa003301.04537466
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.03270792
56Vitamin B6 metabolism_Homo sapiens_hsa007500.96656155
57Sulfur relay system_Homo sapiens_hsa041220.92551266
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87389056
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87137903
60Other glycan degradation_Homo sapiens_hsa005110.84771653
61Glutathione metabolism_Homo sapiens_hsa004800.79507248
62Glycerolipid metabolism_Homo sapiens_hsa005610.79451935
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76451675
64Lysine degradation_Homo sapiens_hsa003100.74417048
65Pentose phosphate pathway_Homo sapiens_hsa000300.67716235
66One carbon pool by folate_Homo sapiens_hsa006700.65620116
67Galactose metabolism_Homo sapiens_hsa000520.64346526
68Fatty acid biosynthesis_Homo sapiens_hsa000610.54440047
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47519738
70Fructose and mannose metabolism_Homo sapiens_hsa000510.45704148
71Metabolic pathways_Homo sapiens_hsa011000.45342870
72Renin-angiotensin system_Homo sapiens_hsa046140.34215507
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33579745
74Prion diseases_Homo sapiens_hsa050200.33184914
75Linoleic acid metabolism_Homo sapiens_hsa005910.24113564
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.21210274
77Mineral absorption_Homo sapiens_hsa049780.20372350
78Insulin resistance_Homo sapiens_hsa049310.20159899
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.19591716
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13063422
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10724414
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07775044
83Amoebiasis_Homo sapiens_hsa051460.04362396
84African trypanosomiasis_Homo sapiens_hsa051430.00453270
85Sphingolipid metabolism_Homo sapiens_hsa006000.00085256
86Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1964632
87Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1874173
88Ether lipid metabolism_Homo sapiens_hsa00565-0.1807767
89Serotonergic synapse_Homo sapiens_hsa04726-0.1753234
90Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1711471
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1669824
92Leishmaniasis_Homo sapiens_hsa05140-0.1640293
93N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1607735
94Insulin signaling pathway_Homo sapiens_hsa04910-0.1582373
95Lysosome_Homo sapiens_hsa04142-0.1495091
96Phagosome_Homo sapiens_hsa04145-0.1493593
97Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1440733
98Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1346585
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1240983
100Protein digestion and absorption_Homo sapiens_hsa04974-0.1158614
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1150267
102Legionellosis_Homo sapiens_hsa05134-0.1013872
103Pertussis_Homo sapiens_hsa05133-0.0948151
104Hepatitis C_Homo sapiens_hsa05160-0.0914216
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0675492
106AMPK signaling pathway_Homo sapiens_hsa04152-0.0626807
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0239009
108Glucagon signaling pathway_Homo sapiens_hsa04922-0.0081226

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