APOC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.08224559
2L-phenylalanine catabolic process (GO:0006559)7.71012794
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.71012794
4epoxygenase P450 pathway (GO:0019373)7.51810108
5L-phenylalanine metabolic process (GO:0006558)7.38496856
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.38496856
7aromatic amino acid family catabolic process (GO:0009074)6.90993410
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.64799752
9omega-hydroxylase P450 pathway (GO:0097267)6.53028502
10indole-containing compound catabolic process (GO:0042436)6.20959922
11indolalkylamine catabolic process (GO:0046218)6.20959922
12tryptophan catabolic process (GO:0006569)6.20959922
13kynurenine metabolic process (GO:0070189)6.05899888
14bile acid biosynthetic process (GO:0006699)5.94656926
15drug metabolic process (GO:0017144)5.88553401
16tryptophan metabolic process (GO:0006568)5.84032596
17glyoxylate metabolic process (GO:0046487)5.77124684
18urea metabolic process (GO:0019627)5.75966044
19urea cycle (GO:0000050)5.75966044
20alpha-linolenic acid metabolic process (GO:0036109)5.67051697
21negative regulation of fibrinolysis (GO:0051918)5.62728857
22* high-density lipoprotein particle remodeling (GO:0034375)5.42564745
23cysteine metabolic process (GO:0006534)5.41584126
24sulfur amino acid catabolic process (GO:0000098)5.41011968
25regulation of fibrinolysis (GO:0051917)5.40922733
26protein carboxylation (GO:0018214)5.40469279
27peptidyl-glutamic acid carboxylation (GO:0017187)5.40469279
28nitrogen cycle metabolic process (GO:0071941)5.30025746
29complement activation, alternative pathway (GO:0006957)5.26467843
30regulation of protein activation cascade (GO:2000257)5.23980795
31serine family amino acid catabolic process (GO:0009071)5.19506678
32regulation of cholesterol esterification (GO:0010872)5.17453914
33oxidative demethylation (GO:0070989)5.16450342
34bile acid metabolic process (GO:0008206)5.11855546
35phenylpropanoid metabolic process (GO:0009698)5.05702211
36aromatic amino acid family metabolic process (GO:0009072)5.02432799
37regulation of plasminogen activation (GO:0010755)4.99405422
38tyrosine metabolic process (GO:0006570)4.89473234
39regulation of complement activation (GO:0030449)4.88041601
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86655635
41negative regulation of hemostasis (GO:1900047)4.82222741
42negative regulation of blood coagulation (GO:0030195)4.82222741
43homocysteine metabolic process (GO:0050667)4.75028138
44alpha-amino acid catabolic process (GO:1901606)4.69015516
45* macromolecular complex remodeling (GO:0034367)4.66586445
46* plasma lipoprotein particle remodeling (GO:0034369)4.66586445
47* protein-lipid complex remodeling (GO:0034368)4.66586445
48* reverse cholesterol transport (GO:0043691)4.65756130
49amino-acid betaine metabolic process (GO:0006577)4.60203662
50lysine metabolic process (GO:0006553)4.59215630
51lysine catabolic process (GO:0006554)4.59215630
52cellular ketone body metabolic process (GO:0046950)4.52221123
53* acylglycerol homeostasis (GO:0055090)4.50734992
54* triglyceride homeostasis (GO:0070328)4.50734992
55fat-soluble vitamin biosynthetic process (GO:0042362)4.48639122
56intestinal cholesterol absorption (GO:0030299)4.46549495
57coenzyme catabolic process (GO:0009109)4.45976504
58* regulation of triglyceride catabolic process (GO:0010896)4.45905551
59bile acid and bile salt transport (GO:0015721)4.45479019
60glycine metabolic process (GO:0006544)4.45085540
61negative regulation of coagulation (GO:0050819)4.40398818
62indolalkylamine metabolic process (GO:0006586)4.39809778
63imidazole-containing compound metabolic process (GO:0052803)4.38081260
64alkaloid metabolic process (GO:0009820)4.37077392
65ethanol metabolic process (GO:0006067)4.34213792
66cellular glucuronidation (GO:0052695)4.33930951
67cellular biogenic amine catabolic process (GO:0042402)4.31525914
68amine catabolic process (GO:0009310)4.31525914
69cellular amino acid catabolic process (GO:0009063)4.31127125
70* phospholipid efflux (GO:0033700)4.30779857
71* negative regulation of sterol transport (GO:0032372)4.30098659
72* negative regulation of cholesterol transport (GO:0032375)4.30098659
73negative regulation of wound healing (GO:0061045)4.30045292
74glutamate metabolic process (GO:0006536)4.29420726
75serine family amino acid metabolic process (GO:0009069)4.21482546
76* plasma lipoprotein particle clearance (GO:0034381)4.17803173
77benzene-containing compound metabolic process (GO:0042537)4.17357927
78acute-phase response (GO:0006953)4.17200978
79hormone catabolic process (GO:0042447)4.16151278
80heme transport (GO:0015886)4.14995393
81arginine metabolic process (GO:0006525)4.12122680
82ethanol oxidation (GO:0006069)4.11788534
83* protein-lipid complex assembly (GO:0065005)4.09676179
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.09642807
85* cholesterol efflux (GO:0033344)4.09323552
86cellular modified amino acid catabolic process (GO:0042219)4.09030397
87S-adenosylmethionine metabolic process (GO:0046500)4.08387515
88low-density lipoprotein particle remodeling (GO:0034374)4.08049662
89dicarboxylic acid biosynthetic process (GO:0043650)4.06808752
90drug catabolic process (GO:0042737)4.06093154
91serine family amino acid biosynthetic process (GO:0009070)4.04870119
92aldehyde catabolic process (GO:0046185)4.03768184
93fibrinolysis (GO:0042730)4.00870947
94positive regulation of lipoprotein lipase activity (GO:0051006)3.99530807
95positive regulation of triglyceride lipase activity (GO:0061365)3.99530807
96positive regulation of blood coagulation (GO:0030194)3.98755289
97positive regulation of hemostasis (GO:1900048)3.98755289
98* plasma lipoprotein particle organization (GO:0071827)3.98246713
99* negative regulation of lipase activity (GO:0060192)3.95904323
100regulation of humoral immune response (GO:0002920)3.93912129
101ketone body metabolic process (GO:1902224)3.91539282
102* very-low-density lipoprotein particle assembly (GO:0034379)3.91361208
103uronic acid metabolic process (GO:0006063)3.85214356
104glucuronate metabolic process (GO:0019585)3.85214356
105positive regulation of lipid catabolic process (GO:0050996)3.84959243
106cofactor catabolic process (GO:0051187)3.83382560
107blood coagulation, intrinsic pathway (GO:0007597)3.82870803
108negative regulation of protein activation cascade (GO:2000258)3.79682524
109organic acid catabolic process (GO:0016054)3.76988190
110carboxylic acid catabolic process (GO:0046395)3.76988190
111regulation of bile acid biosynthetic process (GO:0070857)3.76381196
112* protein-lipid complex subunit organization (GO:0071825)3.75525118
113positive regulation of fatty acid biosynthetic process (GO:0045723)3.75119185
114complement activation, classical pathway (GO:0006958)3.75076238
115phospholipid homeostasis (GO:0055091)3.74480093
116* plasma lipoprotein particle assembly (GO:0034377)3.73819372
117complement activation (GO:0006956)3.69916969
118* cholesterol homeostasis (GO:0042632)3.69822583
119positive regulation of coagulation (GO:0050820)3.69635476
120short-chain fatty acid metabolic process (GO:0046459)3.69120493
121protein activation cascade (GO:0072376)3.68921863
122acetyl-CoA metabolic process (GO:0006084)3.68738819
123regulation of cholesterol homeostasis (GO:2000188)3.68107027
124* sterol homeostasis (GO:0055092)3.63660723
125cytolysis (GO:0019835)3.63214205
126flavonoid metabolic process (GO:0009812)3.62820567
127NAD biosynthetic process (GO:0009435)3.61550337
128pyridine nucleotide biosynthetic process (GO:0019363)3.57990429
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.57990429
130opsonization (GO:0008228)3.54899336
131response to nitrosative stress (GO:0051409)3.53975530
132doxorubicin metabolic process (GO:0044598)3.50981179
133daunorubicin metabolic process (GO:0044597)3.50981179
134polyketide metabolic process (GO:0030638)3.50981179
135* lipoprotein metabolic process (GO:0042157)3.49537430
136intestinal absorption (GO:0050892)3.48177214
137drug transmembrane transport (GO:0006855)3.41414160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.40868946
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21167851
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.02852649
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48914325
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29759774
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05045748
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.91624336
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03264057
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99233979
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06146079
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9766153
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96033039
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92338307
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.58583922
15HTT_18923047_ChIP-ChIP_STHdh_Human1.55630095
16CLOCK_20551151_ChIP-Seq_293T_Human1.54949268
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39800125
18GATA1_22025678_ChIP-Seq_K562_Human1.37655519
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29015532
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27579124
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.21727666
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19610932
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18105383
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14817293
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04920345
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03175462
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02090675
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97406041
29SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94189967
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93235624
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86080677
32RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86062028
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85530646
34IRF8_22096565_ChIP-ChIP_GC-B_Human0.83431382
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82744226
36CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82608902
37GATA4_25053715_ChIP-Seq_YYC3_Human0.82546800
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82185345
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81190328
40SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80191078
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79513333
42KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77667220
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77252204
44SOX2_21211035_ChIP-Seq_LN229_Human0.75009671
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74991946
46RARA_24833708_ChIP-Seq_LIVER_Mouse0.74587379
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74485191
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72985278
49TCF4_18268006_ChIP-ChIP_LS174T_Human0.72664576
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71033514
51ZNF263_19887448_ChIP-Seq_K562_Human0.70858233
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70446466
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67281851
54ESR2_21235772_ChIP-Seq_MCF-7_Human0.67193494
55HNFA_21074721_ChIP-Seq_CACO-2_Human0.67151303
56SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66883694
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.66422144
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66409516
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.65486082
60* CTCF_27219007_Chip-Seq_Bcells_Human0.65164082
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65006560
62* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64805201
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64500522
64RAC3_21632823_ChIP-Seq_H3396_Human0.64368043
65RARB_24833708_ChIP-Seq_LIVER_Mouse0.64354881
66TP53_18474530_ChIP-ChIP_U2OS_Human0.64044266
67JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.63664919
68NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63242433
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63242433
70RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62850384
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62821317
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62782184
73* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60100444
74CDX2_22108803_ChIP-Seq_LS180_Human0.58464367
75ETV2_25802403_ChIP-Seq_MESCs_Mouse0.58369376
76DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57947530
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.57180864
78CEBPB_22108803_ChIP-Seq_LS180_Human0.57171331
79PHF8_20622853_ChIP-Seq_HELA_Human0.57162746
80SOX2_22085726_ChIP-Seq_NPCs_Mouse0.56531051
81LXR_22292898_ChIP-Seq_THP-1_Human0.56504875
82* SA1_27219007_Chip-Seq_Bcells_Human0.55451879
83EGR1_19032775_ChIP-ChIP_M12_Human0.55292818
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54784474
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54747135
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.54598184
87GATA3_24758297_ChIP-Seq_MCF-7_Human0.52940374
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52123053
89MYC_19915707_ChIP-ChIP_AK7_Human0.52099658
90AR_20517297_ChIP-Seq_VCAP_Human0.51903308
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51669017
92FOXA1_25552417_ChIP-Seq_VCAP_Human0.51509593
93CTCF_20526341_ChIP-Seq_ESCs_Human0.51098388
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50537731
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50405293
96CDX2_20551321_ChIP-Seq_CACO-2_Human0.50381017
97POU5F1_16518401_ChIP-PET_MESCs_Mouse0.49661039
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.49335182
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48348880
100CBP_21632823_ChIP-Seq_H3396_Human0.47376365
101STAT1_17558387_ChIP-Seq_HELA_Human0.47288055
102P53_21459846_ChIP-Seq_SAOS-2_Human0.46916709
103PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45441303
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44483365
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44131121
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43338512
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.42771737
108TAF2_19829295_ChIP-Seq_ESCs_Human0.42044587
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.41307124
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.41236248
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.40941085
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40749235
113GATA1_19941826_ChIP-Seq_K562_Human0.40626290
114GATA6_25053715_ChIP-Seq_YYC3_Human0.40281037
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40134840
116BCAT_22108803_ChIP-Seq_LS180_Human0.39535972
117GATA2_19941826_ChIP-Seq_K562_Human0.39510518
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38397083
119TAF15_26573619_Chip-Seq_HEK293_Human0.38156940
120MYC_27129775_Chip-Seq_CORNEA_Mouse0.37927233
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37576838
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.37167788
123LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36707822
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.35342253
125SPI1_26923725_Chip-Seq_HPCs_Mouse0.35197970
126NCOR_22424771_ChIP-Seq_293T_Human0.34670704
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34557841
128SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33091303
129SOX2_20726797_ChIP-Seq_SW620_Human0.32712501
130* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.32483819
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.32476761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.45963715
2MP0005360_urolithiasis7.67326564
3MP0005085_abnormal_gallbladder_physiolo6.45112359
4MP0005365_abnormal_bile_salt6.18734671
5MP0008875_abnormal_xenobiotic_pharmacok5.23189133
6MP0003806_abnormal_nucleotide_metabolis4.27507108
7MP0003252_abnormal_bile_duct3.92768689
8* MP0010329_abnormal_lipoprotein_level3.53836596
9MP0005083_abnormal_biliary_tract3.01033154
10MP0003195_calcinosis2.83886697
11MP0005332_abnormal_amino_acid2.78312401
12MP0001666_abnormal_nutrient_absorption2.68222135
13* MP0009840_abnormal_foam_cell2.56848725
14MP0003191_abnormal_cellular_cholesterol2.36251231
15MP0000609_abnormal_liver_physiology2.17259683
16MP0004019_abnormal_vitamin_homeostasis2.16756292
17* MP0002118_abnormal_lipid_homeostasis2.09737946
18MP0002138_abnormal_hepatobiliary_system1.94327073
19MP0003868_abnormal_feces_composition1.91099892
20MP0005319_abnormal_enzyme/_coenzyme1.83481007
21MP0001764_abnormal_homeostasis1.68400930
22MP0009697_abnormal_copulation1.64014751
23MP0005584_abnormal_enzyme/coenzyme_acti1.58228057
24MP0005451_abnormal_body_composition1.51167564
25MP0003011_delayed_dark_adaptation1.41077058
26MP0003186_abnormal_redox_activity1.27057985
27MP0009643_abnormal_urine_homeostasis1.23744406
28MP0003656_abnormal_erythrocyte_physiolo1.22594790
29MP0003705_abnormal_hypodermis_morpholog1.18028275
30MP0000598_abnormal_liver_morphology1.17000212
31MP0005647_abnormal_sex_gland1.13064866
32MP0000604_amyloidosis1.11133308
33MP0009764_decreased_sensitivity_to1.06388455
34MP0009763_increased_sensitivity_to1.01453181
35MP0002254_reproductive_system_inflammat0.99341922
36MP0003879_abnormal_hair_cell0.93652456
37MP0005636_abnormal_mineral_homeostasis0.92367640
38MP0010368_abnormal_lymphatic_system0.90913538
39MP0008469_abnormal_protein_level0.88766415
40* MP0009642_abnormal_blood_homeostasis0.86993946
41MP0005408_hypopigmentation0.83852595
42MP0006036_abnormal_mitochondrial_physio0.83033018
43MP0005376_homeostasis/metabolism_phenot0.80895997
44MP0002132_abnormal_respiratory_system0.80032505
45MP0002876_abnormal_thyroid_physiology0.79588263
46MP0009765_abnormal_xenobiotic_induced0.79132428
47MP0003183_abnormal_peptide_metabolism0.78326031
48MP0005670_abnormal_white_adipose0.76051483
49MP0005084_abnormal_gallbladder_morpholo0.75983635
50* MP0002078_abnormal_glucose_homeostasis0.75523456
51MP0000566_synostosis0.73228543
52MP0002971_abnormal_brown_adipose0.72422494
53MP0005334_abnormal_fat_pad0.70109375
54MP0003690_abnormal_glial_cell0.68753681
55MP0009053_abnormal_anal_canal0.68048879
56MP0004264_abnormal_extraembryonic_tissu0.67977615
57MP0001915_intracranial_hemorrhage0.67890356
58MP0005220_abnormal_exocrine_pancreas0.67885007
59MP0005535_abnormal_body_temperature0.66873889
60MP0005266_abnormal_metabolism0.66516394
61MP0003329_amyloid_beta_deposits0.65526268
62MP0004130_abnormal_muscle_cell0.65390966
63MP0001661_extended_life_span0.63228938
64MP0000639_abnormal_adrenal_gland0.60930030
65MP0001756_abnormal_urination0.58015722
66MP0002822_catalepsy0.57880150
67MP0005409_darkened_coat_color0.56328092
68MP0006035_abnormal_mitochondrial_morpho0.55928982
69MP0005464_abnormal_platelet_physiology0.51986497
70MP0005395_other_phenotype0.48743863
71MP0003718_maternal_effect0.48463063
72MP0003638_abnormal_response/metabolism_0.48195361
73MP0005023_abnormal_wound_healing0.48067985
74MP0005187_abnormal_penis_morphology0.46787424
75MP0008874_decreased_physiological_sensi0.46742638
76* MP0005448_abnormal_energy_balance0.46354113
77MP0002089_abnormal_postnatal_growth/wei0.46338972
78MP0008873_increased_physiological_sensi0.46153828
79MP0002136_abnormal_kidney_physiology0.44719843
80MP0004782_abnormal_surfactant_physiolog0.42889038
81MP0005248_abnormal_Harderian_gland0.42591830
82MP0002837_dystrophic_cardiac_calcinosis0.42250185
83MP0003878_abnormal_ear_physiology0.41963241
84MP0005377_hearing/vestibular/ear_phenot0.41963241
85MP0002928_abnormal_bile_duct0.41882346
86MP0003075_altered_response_to0.41813289
87MP0003436_decreased_susceptibility_to0.41657192
88MP0003724_increased_susceptibility_to0.40545719
89MP0010155_abnormal_intestine_physiology0.40043117
90* MP0003953_abnormal_hormone_level0.39039013
91MP0008872_abnormal_physiological_respon0.39007327
92MP0005166_decreased_susceptibility_to0.38919334
93MP0005666_abnormal_adipose_tissue0.36700636
94MP0004381_abnormal_hair_follicle0.36105502
95MP0009672_abnormal_birth_weight0.35698501
96MP0009785_altered_susceptibility_to0.34909061
97MP0002796_impaired_skin_barrier0.34663914
98MP0009115_abnormal_fat_cell0.34203858
99MP0002249_abnormal_larynx_morphology0.33342329
100MP0000579_abnormal_nail_morphology0.32977443
101MP0006082_CNS_inflammation0.32959869
102MP0001243_abnormal_dermal_layer0.31965827
103MP0004883_abnormal_blood_vessel0.31748673
104MP0000230_abnormal_systemic_arterial0.31119405
105MP0002168_other_aberrant_phenotype0.30088006
106MP0001853_heart_inflammation0.28826444
107MP0001881_abnormal_mammary_gland0.28744544
108MP0002282_abnormal_trachea_morphology0.28693483
109MP0009384_cardiac_valve_regurgitation0.28343744
110MP0001845_abnormal_inflammatory_respons0.27962068
111MP0004147_increased_porphyrin_level0.27433624
112* MP0000249_abnormal_blood_vessel0.26985006
113MP0000920_abnormal_myelination0.26925629
114MP0001986_abnormal_taste_sensitivity0.25940782
115MP0005164_abnormal_response_to0.24937090
116MP0002090_abnormal_vision0.23921428
117MP0002909_abnormal_adrenal_gland0.23847995
118MP0005058_abnormal_lysosome_morphology0.22754435
119* MP0002970_abnormal_white_adipose0.22652684
120MP0002060_abnormal_skin_morphology0.22481706
121MP0003632_abnormal_nervous_system0.21427768
122MP0004272_abnormal_basement_membrane0.19884187
123MP0002135_abnormal_kidney_morphology0.19631888
124MP0003959_abnormal_lean_body0.17408752

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.57991787
2Deep venous thrombosis (HP:0002625)7.45635537
3Intrahepatic cholestasis (HP:0001406)7.26031108
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.81750830
5Prolonged partial thromboplastin time (HP:0003645)6.56601619
6Xanthomatosis (HP:0000991)6.34025073
7* Hypobetalipoproteinemia (HP:0003563)5.85154208
8Complement deficiency (HP:0004431)5.23476306
9* Hyperlipoproteinemia (HP:0010980)4.83575302
10Joint hemorrhage (HP:0005261)4.80731923
11Hyperammonemia (HP:0001987)4.66047603
12Epidermoid cyst (HP:0200040)4.49967626
13* Hypolipoproteinemia (HP:0010981)4.45661985
14Hyperglycinemia (HP:0002154)4.44813223
15Abnormality of the common coagulation pathway (HP:0010990)4.41188014
16Abnormality of methionine metabolism (HP:0010901)4.33629992
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.31558456
18Ketosis (HP:0001946)4.29209190
19Hypoalphalipoproteinemia (HP:0003233)4.26341239
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.22922665
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18935432
22Fat malabsorption (HP:0002630)4.14200878
23* Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09873683
24Hyperglycinuria (HP:0003108)3.98976590
25Abnormality of serine family amino acid metabolism (HP:0010894)3.95494323
26Abnormality of glycine metabolism (HP:0010895)3.95494323
27Abnormality of pyrimidine metabolism (HP:0004353)3.90623774
28Hypoglycemic coma (HP:0001325)3.89552195
29Abnormality of complement system (HP:0005339)3.81832086
30Abnormality of the intrinsic pathway (HP:0010989)3.75868934
31Conjugated hyperbilirubinemia (HP:0002908)3.72369468
32Hypercholesterolemia (HP:0003124)3.65460152
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43255942
34Abnormality of fatty-acid metabolism (HP:0004359)3.38796723
35Hyperbilirubinemia (HP:0002904)3.35889383
36Delayed CNS myelination (HP:0002188)3.12583055
37Steatorrhea (HP:0002570)3.11866253
38Abnormality of nucleobase metabolism (HP:0010932)3.11332654
39Abnormality of serum amino acid levels (HP:0003112)3.09185184
40Ketoacidosis (HP:0001993)3.03806272
41Spontaneous abortion (HP:0005268)3.00468511
42Hepatocellular carcinoma (HP:0001402)2.96375265
43Myocardial infarction (HP:0001658)2.94505509
44Hypochromic microcytic anemia (HP:0004840)2.93897157
45Metabolic acidosis (HP:0001942)2.82037008
46Skin nodule (HP:0200036)2.76938516
47Abnormality of purine metabolism (HP:0004352)2.71687094
48Systemic lupus erythematosus (HP:0002725)2.68791645
49Osteomalacia (HP:0002749)2.66358612
50Lethargy (HP:0001254)2.64377855
51Dicarboxylic aciduria (HP:0003215)2.62635127
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62635127
53Vascular calcification (HP:0004934)2.61337006
54Acanthocytosis (HP:0001927)2.54440594
55Abnormality of urine glucose concentration (HP:0011016)2.51136291
56Glycosuria (HP:0003076)2.51136291
57Abnormal gallbladder morphology (HP:0012437)2.49911274
58Hypoglycemic seizures (HP:0002173)2.49587478
59Spastic diplegia (HP:0001264)2.47573326
60Cholecystitis (HP:0001082)2.47380813
61Abnormal gallbladder physiology (HP:0012438)2.47380813
62Cerebral edema (HP:0002181)2.44535105
63Cholelithiasis (HP:0001081)2.43985026
64Mitral stenosis (HP:0001718)2.42913384
65Gout (HP:0001997)2.42814870
66Purpura (HP:0000979)2.41766271
67Glomerulonephritis (HP:0000099)2.39956213
68Irritability (HP:0000737)2.38405613
69Malnutrition (HP:0004395)2.38038007
70Amyloidosis (HP:0011034)2.36318253
71Neonatal onset (HP:0003623)2.35838871
72Hyperphosphaturia (HP:0003109)2.35227620
73Cardiovascular calcification (HP:0011915)2.31602057
74Recurrent gram-negative bacterial infections (HP:0005420)2.26608845
75Esophageal varix (HP:0002040)2.19817699
76Late onset (HP:0003584)2.18950751
77Gingival bleeding (HP:0000225)2.18290618
78Brushfield spots (HP:0001088)2.16652730
79Proximal tubulopathy (HP:0000114)2.16639175
80Pancreatitis (HP:0001733)2.16381421
81Sensorimotor neuropathy (HP:0007141)2.15766424
82Menorrhagia (HP:0000132)2.15414611
83Reduced antithrombin III activity (HP:0001976)2.13223246
84Vomiting (HP:0002013)2.10401966
85Enlarged kidneys (HP:0000105)2.10069168
86Abnormality of the Achilles tendon (HP:0005109)2.09809713
87Pulmonary embolism (HP:0002204)2.07140009
88Thrombophlebitis (HP:0004418)2.07097522
89Opisthotonus (HP:0002179)2.05344909
90Joint swelling (HP:0001386)2.04548803
91Generalized aminoaciduria (HP:0002909)2.03554556
92Abnormal urine phosphate concentration (HP:0012599)2.03309567
93Hyperinsulinemic hypoglycemia (HP:0000825)2.03059491
94Abnormality of the gallbladder (HP:0005264)2.03032163
95Poikilocytosis (HP:0004447)2.01231993
96Hemorrhage of the eye (HP:0011885)2.00234817
97Arthropathy (HP:0003040)1.98783548
98Rickets (HP:0002748)1.94546606
99Abnormality of iron homeostasis (HP:0011031)1.94285473
100Hydroxyprolinuria (HP:0003080)1.93169485
101Abnormality of proline metabolism (HP:0010907)1.93169485
102Retinal atrophy (HP:0001105)1.93085456
103Abnormality of transition element cation homeostasis (HP:0011030)1.91050574
104Abnormal cartilage morphology (HP:0002763)1.90762801
105Pigmentary retinal degeneration (HP:0001146)1.90379607
106Increased serum ferritin (HP:0003281)1.90300698
107Hypophosphatemic rickets (HP:0004912)1.88715599
108Elevated alkaline phosphatase (HP:0003155)1.88322888
109Renal cortical cysts (HP:0000803)1.84521207
110Nausea (HP:0002018)1.84268767
111Alkalosis (HP:0001948)1.83647499
112Abnormality of alkaline phosphatase activity (HP:0004379)1.82139314
113Fair hair (HP:0002286)1.81928772
114Elevated hepatic transaminases (HP:0002910)1.81148948
115Status epilepticus (HP:0002133)1.80962868
116Abnormal enzyme/coenzyme activity (HP:0012379)1.79310786
117Abnormality of vitamin metabolism (HP:0100508)1.79025769
118Bifid scrotum (HP:0000048)1.78990093
119Epistaxis (HP:0000421)1.73688835
120Reticulocytosis (HP:0001923)1.73075031
121Nephritis (HP:0000123)1.72858868
122Hypophosphatemia (HP:0002148)1.72056405
123Facial shape deformation (HP:0011334)1.71812855
124Potter facies (HP:0002009)1.71812855
125Widely patent fontanelles and sutures (HP:0004492)1.67611816
126Nephrolithiasis (HP:0000787)1.67154372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.26799791
2FGFR44.62219320
3SIK14.60074329
4ERN14.55138742
5MUSK3.75402117
6ACVR1B3.46114678
7TAOK33.01895852
8INSRR2.81580911
9ERBB42.76377247
10PDK22.63566516
11TESK22.34584985
12MAP2K42.34051129
13PKN22.25912091
14MAP3K122.16765548
15MST1R2.14209151
16FLT31.92335659
17PIK3CG1.80362403
18MAPK111.80053617
19TRIB31.77561015
20PIK3CA1.70679343
21TYK21.67734282
22LATS11.62331811
23MAP3K21.55578849
24DAPK21.52259277
25ABL21.51080318
26PTK61.50461962
27FRK1.45970640
28NEK91.35380237
29PRPF4B1.34159080
30FGFR21.32293439
31KDR1.30284151
32MYLK1.22371188
33JAK21.18999530
34MAP3K71.18938090
35GRK61.18367163
36NTRK31.13154947
37PINK11.12966873
38PRKAA21.11515007
39TBK11.10315743
40PRKG21.10127561
41EPHA21.08451195
42MAP2K31.07213217
43NLK1.02127292
44MAP3K100.99882423
45MAPK40.98550607
46JAK10.97534807
47MAP3K140.96532470
48ERBB20.96118164
49PRKCZ0.93204845
50MAP3K30.91183213
51MAPK150.90147847
52PDGFRA0.86598244
53MAP3K110.86100993
54MET0.85198368
55STK38L0.84819519
56EPHB10.83191452
57CDK60.82440301
58LMTK20.81928469
59MAPK120.79636942
60PRKACG0.76101931
61MAP2K60.75294818
62TIE10.74122197
63DYRK1B0.73117431
64CAMK2G0.72688228
65CSK0.72594772
66EPHA30.70429901
67GSK3A0.68484722
68IRAK30.66081295
69RIPK10.65151193
70CAMK1D0.64711932
71KSR20.63863332
72PRKAA10.63162748
73SGK30.60537882
74PTK20.58790771
75FER0.58031010
76PRKACA0.57721051
77PRKG10.57555606
78MAPK70.56692567
79IKBKE0.56308286
80FGFR10.55634233
81TGFBR20.54777258
82PDPK10.53575822
83CSF1R0.53001424
84PRKCQ0.52852674
85FGFR30.52406268
86CSNK1G10.52192133
87EPHA40.51404763
88TAOK20.49889298
89WNK30.47234103
90MAP2K10.45308782
91PRKCB0.45238463
92CSNK1D0.44888158
93MAP3K50.44768648
94GRK10.44549207
95SRC0.44192507
96MAP3K130.42721851
97IGF1R0.42180359
98SGK20.41330607
99CDK40.41261421
100PRKACB0.41150041
101ICK0.40388297
102PRKCG0.40220735
103RET0.39889577
104PIM20.38694986
105ZAP700.38450246
106PBK0.38224340
107TNIK0.38167539
108MAP3K60.37406519
109CAMK40.34209446
110CSNK1G20.33468142
111MATK0.33056106
112MTOR0.32846366
113PDK10.32424061
114CSNK1G30.32404690
115EGFR0.32111679
116MAPKAPK30.32102987
117PKN10.30967956
118SGK10.30838605
119MAP2K20.30836461
120MAP3K10.29831326
121SGK4940.29261394
122SGK2230.29261394
123RPS6KA30.28878163
124CSNK2A10.28587703
125LATS20.27730147
126CSNK2A20.27334182
127CSNK1E0.27142855
128SCYL20.27010409
129CDK120.26678082
130PRKCA0.26366193
131IRAK20.24806660
132BMX0.24132256
133AKT30.23647903
134CSNK1A1L0.23253515
135IRAK10.21823546
136PAK30.20879951
137PDK30.20764545

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47918453
2Nitrogen metabolism_Homo sapiens_hsa009103.49641754
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39814826
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37530883
5Arginine biosynthesis_Homo sapiens_hsa002203.09041445
6Complement and coagulation cascades_Homo sapiens_hsa046102.70546613
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70452623
8Tryptophan metabolism_Homo sapiens_hsa003802.68837703
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61935809
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52766450
11Fatty acid degradation_Homo sapiens_hsa000712.46758337
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36844482
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27975356
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18764019
15Butanoate metabolism_Homo sapiens_hsa006502.12841240
16Peroxisome_Homo sapiens_hsa041462.07609667
17Chemical carcinogenesis_Homo sapiens_hsa052041.99747658
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98043939
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.94500046
20Histidine metabolism_Homo sapiens_hsa003401.92116250
21Propanoate metabolism_Homo sapiens_hsa006401.90372472
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.79686824
23Fatty acid metabolism_Homo sapiens_hsa012121.79586122
24* PPAR signaling pathway_Homo sapiens_hsa033201.79414053
25Caffeine metabolism_Homo sapiens_hsa002321.78965304
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73814072
27Retinol metabolism_Homo sapiens_hsa008301.73757643
28Staphylococcus aureus infection_Homo sapiens_hsa051501.71513595
29beta-Alanine metabolism_Homo sapiens_hsa004101.69217329
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66088920
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61086723
32Phenylalanine metabolism_Homo sapiens_hsa003601.56906736
33Selenocompound metabolism_Homo sapiens_hsa004501.56811812
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52347801
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51384370
36Bile secretion_Homo sapiens_hsa049761.51100799
37Tyrosine metabolism_Homo sapiens_hsa003501.44507316
38Sulfur metabolism_Homo sapiens_hsa009201.38968662
39Pyruvate metabolism_Homo sapiens_hsa006201.36881861
40Fatty acid elongation_Homo sapiens_hsa000621.33302086
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32926009
42Starch and sucrose metabolism_Homo sapiens_hsa005001.31429510
43Folate biosynthesis_Homo sapiens_hsa007901.26789451
44Fat digestion and absorption_Homo sapiens_hsa049751.24084424
45Biosynthesis of amino acids_Homo sapiens_hsa012301.21209023
46Steroid biosynthesis_Homo sapiens_hsa001001.18404703
47ABC transporters_Homo sapiens_hsa020101.17084235
48Carbon metabolism_Homo sapiens_hsa012001.13107886
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03239444
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.02090461
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.01801735
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97653180
53Arginine and proline metabolism_Homo sapiens_hsa003300.97317593
54Sulfur relay system_Homo sapiens_hsa041220.95916859
55Vitamin B6 metabolism_Homo sapiens_hsa007500.89513459
56Vitamin digestion and absorption_Homo sapiens_hsa049770.89241222
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88517225
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85829252
59Lysine degradation_Homo sapiens_hsa003100.79356272
60One carbon pool by folate_Homo sapiens_hsa006700.74195022
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70958119
62Glycerolipid metabolism_Homo sapiens_hsa005610.68365688
63Glutathione metabolism_Homo sapiens_hsa004800.67944476
64Pentose phosphate pathway_Homo sapiens_hsa000300.58963928
65Fatty acid biosynthesis_Homo sapiens_hsa000610.53458205
66Mineral absorption_Homo sapiens_hsa049780.51652115
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49111894
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47338758
69Metabolic pathways_Homo sapiens_hsa011000.46279266
70Prion diseases_Homo sapiens_hsa050200.34486947
71Other glycan degradation_Homo sapiens_hsa005110.31722262
72Galactose metabolism_Homo sapiens_hsa000520.28920611
73Fructose and mannose metabolism_Homo sapiens_hsa000510.27531753
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25601622
75Linoleic acid metabolism_Homo sapiens_hsa005910.23035698
76Pertussis_Homo sapiens_hsa051330.22446190
77Insulin resistance_Homo sapiens_hsa049310.21824417
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.20532869
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19222687
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.16830039
81Sphingolipid metabolism_Homo sapiens_hsa006000.15246272
82Protein digestion and absorption_Homo sapiens_hsa049740.09706095
83Glucagon signaling pathway_Homo sapiens_hsa049220.08490430
84AMPK signaling pathway_Homo sapiens_hsa041520.00969322
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2461732
86Amoebiasis_Homo sapiens_hsa05146-0.2442222
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2440214
88Ether lipid metabolism_Homo sapiens_hsa00565-0.2369221
89Type II diabetes mellitus_Homo sapiens_hsa04930-0.2276283
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2023488
91Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1878232
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1862811
93Hepatitis C_Homo sapiens_hsa05160-0.1841294
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1838991
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1733149
96Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1682264
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1617451
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1519351
99Regulation of autophagy_Homo sapiens_hsa04140-0.1478371
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1320459
101African trypanosomiasis_Homo sapiens_hsa05143-0.1305261
102N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1213273
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1078443
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1023184
105Serotonergic synapse_Homo sapiens_hsa04726-0.1003609
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0731767
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0675585
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0301621

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