APOC4-APOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)8.65356184
2regulation of fibrinolysis (GO:0051917)8.56700617
3glyoxylate metabolic process (GO:0046487)7.47141000
4complement activation, alternative pathway (GO:0006957)7.38045999
5regulation of protein activation cascade (GO:2000257)7.35882596
6L-phenylalanine catabolic process (GO:0006559)7.33343223
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.33343223
8drug catabolic process (GO:0042737)7.23193755
9exogenous drug catabolic process (GO:0042738)7.15946695
10peptidyl-glutamic acid carboxylation (GO:0017187)7.03069864
11protein carboxylation (GO:0018214)7.03069864
12regulation of complement activation (GO:0030449)6.91065687
13negative regulation of cholesterol transport (GO:0032375)6.87005143
14negative regulation of sterol transport (GO:0032372)6.87005143
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.78816779
16L-phenylalanine metabolic process (GO:0006558)6.78816779
17fibrinolysis (GO:0042730)6.76353717
18epoxygenase P450 pathway (GO:0019373)6.38104107
19phospholipid efflux (GO:0033700)6.21862996
20urea metabolic process (GO:0019627)6.21845236
21blood coagulation, intrinsic pathway (GO:0007597)6.14060747
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.10357673
23regulation of cholesterol esterification (GO:0010872)5.96075226
24omega-hydroxylase P450 pathway (GO:0097267)5.87678805
25nitrogen cycle metabolic process (GO:0071941)5.64071737
26cellular glucuronidation (GO:0052695)5.58920881
27regulation of plasminogen activation (GO:0010755)5.58583754
28regulation of triglyceride catabolic process (GO:0010896)5.49571622
29urea cycle (GO:0000050)5.47211487
30protein-lipid complex remodeling (GO:0034368)5.44296238
31macromolecular complex remodeling (GO:0034367)5.44296238
32plasma lipoprotein particle remodeling (GO:0034369)5.44296238
33high-density lipoprotein particle remodeling (GO:0034375)5.42916990
34glucuronate metabolic process (GO:0019585)5.32622384
35uronic acid metabolic process (GO:0006063)5.32622384
36cholesterol efflux (GO:0033344)5.27574328
37ethanol oxidation (GO:0006069)5.24142360
38very-low-density lipoprotein particle assembly (GO:0034379)5.22607950
39serine family amino acid catabolic process (GO:0009071)5.20572734
40bile acid biosynthetic process (GO:0006699)5.18930667
41aromatic amino acid family catabolic process (GO:0009074)5.18296240
42negative regulation of hemostasis (GO:1900047)5.12803306
43negative regulation of blood coagulation (GO:0030195)5.12803306
44drug metabolic process (GO:0017144)4.94444973
45triglyceride homeostasis (GO:0070328)4.89477283
46acylglycerol homeostasis (GO:0055090)4.89477283
47oxidative demethylation (GO:0070989)4.88189098
48reverse cholesterol transport (GO:0043691)4.87002248
49positive regulation of lipoprotein lipase activity (GO:0051006)4.82936789
50positive regulation of triglyceride lipase activity (GO:0061365)4.82936789
51phenylpropanoid metabolic process (GO:0009698)4.81612940
52bile acid metabolic process (GO:0008206)4.80568373
53plasma lipoprotein particle clearance (GO:0034381)4.79343801
54protein activation cascade (GO:0072376)4.77318589
55plasma lipoprotein particle assembly (GO:0034377)4.71584481
56negative regulation of lipase activity (GO:0060192)4.69418017
57negative regulation of coagulation (GO:0050819)4.67946009
58positive regulation of blood coagulation (GO:0030194)4.60402775
59positive regulation of hemostasis (GO:1900048)4.60402775
60glycine metabolic process (GO:0006544)4.58245117
61negative regulation of wound healing (GO:0061045)4.57511895
62acute-phase response (GO:0006953)4.39842301
63negative regulation of protein activation cascade (GO:2000258)4.32038661
64regulation of humoral immune response (GO:0002920)4.30691125
65bile acid and bile salt transport (GO:0015721)4.29929237
66regulation of lipoprotein particle clearance (GO:0010984)4.26958866
67complement activation (GO:0006956)4.26282364
68positive regulation of coagulation (GO:0050820)4.26066400
69ethanol metabolic process (GO:0006067)4.24151971
70complement activation, classical pathway (GO:0006958)4.24068177
71plasma lipoprotein particle organization (GO:0071827)4.23501415
72protein-lipid complex assembly (GO:0065005)4.23104669
73intestinal cholesterol absorption (GO:0030299)4.19337850
74tyrosine metabolic process (GO:0006570)4.05450620
75low-density lipoprotein particle remodeling (GO:0034374)4.04586569
76protein-lipid complex subunit organization (GO:0071825)3.99972006
77alkaloid metabolic process (GO:0009820)3.90465785
78amino-acid betaine metabolic process (GO:0006577)3.89558659
79imidazole-containing compound metabolic process (GO:0052803)3.88372207
80regulation of apoptotic cell clearance (GO:2000425)3.83872929
81serine family amino acid metabolic process (GO:0009069)3.76828108
82S-adenosylmethionine metabolic process (GO:0046500)3.74816718
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.73469313
84positive regulation of fatty acid biosynthetic process (GO:0045723)3.70335881
85heme transport (GO:0015886)3.69993634
86arginine metabolic process (GO:0006525)3.69116655
87glutamate metabolic process (GO:0006536)3.68037393
88hormone catabolic process (GO:0042447)3.67254711
89negative regulation of fatty acid biosynthetic process (GO:0045717)3.65658612
90negative regulation of lipid transport (GO:0032369)3.63255245
91fat-soluble vitamin biosynthetic process (GO:0042362)3.62384356
92positive regulation of lipid catabolic process (GO:0050996)3.61273530
93daunorubicin metabolic process (GO:0044597)3.59387565
94polyketide metabolic process (GO:0030638)3.59387565
95doxorubicin metabolic process (GO:0044598)3.59387565
96negative regulation of complement activation (GO:0045916)3.58968625
97alpha-amino acid catabolic process (GO:1901606)3.53922960
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52000880
99acute inflammatory response (GO:0002526)3.49284146
100lipoprotein metabolic process (GO:0042157)3.41878720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.12604619
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.47493198
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.00798333
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.60643525
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.83467318
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.81946199
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59923884
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.22086721
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92600155
10FOXA2_19822575_ChIP-Seq_HepG2_Human2.61936985
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.48209914
12HNF4A_19822575_ChIP-Seq_HepG2_Human2.44142028
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10792045
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05958602
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4192094
16ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59586647
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53415216
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37330751
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.30318635
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25008022
21HTT_18923047_ChIP-ChIP_STHdh_Human1.24404649
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23939680
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.18221059
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16834437
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16026565
26LXR_22292898_ChIP-Seq_THP-1_Human1.04512994
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04145420
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03826421
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.00669616
30GATA4_25053715_ChIP-Seq_YYC3_Human1.00125765
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99244359
32CDX2_20551321_ChIP-Seq_CACO-2_Human0.98512657
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98095765
34AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94628854
35ESR2_21235772_ChIP-Seq_MCF-7_Human0.93207475
36CLOCK_20551151_ChIP-Seq_293T_Human0.92771331
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90504592
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90504402
39SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85909574
40GATA6_25053715_ChIP-Seq_YYC3_Human0.85625972
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83936874
42PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82805670
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81463317
44SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81241314
45KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79675318
46SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79093194
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78353734
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76125693
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75511738
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75500576
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74934987
52SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73754588
53CEBPB_22108803_ChIP-Seq_LS180_Human0.73502182
54SOX2_21211035_ChIP-Seq_LN229_Human0.71312031
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70887957
56TCF4_18268006_ChIP-ChIP_LS174T_Human0.69795521
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68869597
58SOX2_20726797_ChIP-Seq_SW620_Human0.68815124
59FOXA1_25552417_ChIP-Seq_VCAP_Human0.67013307
60NFE2_27457419_Chip-Seq_LIVER_Mouse0.66912679
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66828958
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65412708
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65254034
64RAC3_21632823_ChIP-Seq_H3396_Human0.63499098
65DNAJC2_21179169_ChIP-ChIP_NT2_Human0.61526319
66ELF1_20517297_ChIP-Seq_JURKAT_Human0.60511370
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60310274
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.60115350
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.59848139
70GATA1_19941827_ChIP-Seq_MEL_Mouse0.59729232
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.59487289
72MYC_19915707_ChIP-ChIP_AK7_Human0.59155798
73SPI1_20517297_ChIP-Seq_HL60_Human0.59004716
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.58788765
75CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.58306185
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57904738
77HNFA_21074721_ChIP-Seq_CACO-2_Human0.57735756
78RARA_24833708_ChIP-Seq_LIVER_Mouse0.57689419
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.55134591
80POU5F1_16518401_ChIP-PET_MESCs_Mouse0.54995906
81SMC4_20622854_ChIP-Seq_HELA_Human0.54817386
82AR_20517297_ChIP-Seq_VCAP_Human0.54421189
83GATA1_22025678_ChIP-Seq_K562_Human0.53539723
84RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53036541
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.52793197
86STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.52096520
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52087380
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.52061089
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51967870
90SA1_27219007_Chip-Seq_Bcells_Human0.51329245
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.51283590
92ERG_21242973_ChIP-ChIP_JURKAT_Human0.51144948
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.50914403
94SMAD1_18555785_Chip-Seq_ESCs_Mouse0.50742220
95P53_21459846_ChIP-Seq_SAOS-2_Human0.49481131
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.49261423
97GATA3_21867929_ChIP-Seq_CD8_Mouse0.49147554
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.48961941
99NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.47488282
100CTCF_27219007_Chip-Seq_Bcells_Human0.46532606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.40651440
2MP0005360_urolithiasis6.49174512
3MP0005365_abnormal_bile_salt5.91603339
4MP0005085_abnormal_gallbladder_physiolo5.85158172
5MP0003195_calcinosis5.56467458
6MP0008875_abnormal_xenobiotic_pharmacok4.66063271
7MP0002138_abnormal_hepatobiliary_system4.22875398
8MP0003252_abnormal_bile_duct3.55404888
9MP0009840_abnormal_foam_cell3.43732578
10MP0001666_abnormal_nutrient_absorption3.43505572
11MP0003868_abnormal_feces_composition3.43012929
12MP0010329_abnormal_lipoprotein_level3.17143667
13MP0009697_abnormal_copulation2.58724837
14MP0005332_abnormal_amino_acid2.29552702
15MP0003806_abnormal_nucleotide_metabolis2.17566687
16MP0003191_abnormal_cellular_cholesterol2.07120505
17MP0002876_abnormal_thyroid_physiology2.02099707
18MP0000609_abnormal_liver_physiology1.90592090
19MP0002118_abnormal_lipid_homeostasis1.76066550
20MP0001764_abnormal_homeostasis1.68337913
21MP0005408_hypopigmentation1.50384768
22MP0005451_abnormal_body_composition1.44518875
23MP0004019_abnormal_vitamin_homeostasis1.42159436
24MP0000604_amyloidosis1.37982091
25MP0010368_abnormal_lymphatic_system1.32638680
26MP0005058_abnormal_lysosome_morphology1.31206519
27MP0005319_abnormal_enzyme/_coenzyme1.20597632
28MP0001915_intracranial_hemorrhage1.11730731
29MP0001661_extended_life_span1.10924901
30MP0000598_abnormal_liver_morphology1.07322045
31MP0005584_abnormal_enzyme/coenzyme_acti0.99451352
32MP0009643_abnormal_urine_homeostasis0.97682117
33MP0002132_abnormal_respiratory_system0.95248554
34MP0005464_abnormal_platelet_physiology0.94699064
35MP0003690_abnormal_glial_cell0.92782760
36MP0008469_abnormal_protein_level0.91946876
37MP0003656_abnormal_erythrocyte_physiolo0.90968379
38MP0009642_abnormal_blood_homeostasis0.87791394
39MP0002971_abnormal_brown_adipose0.84185463
40MP0003186_abnormal_redox_activity0.83136621
41MP0005376_homeostasis/metabolism_phenot0.82871887
42MP0009053_abnormal_anal_canal0.82610046
43MP0003879_abnormal_hair_cell0.78455664
44MP0005636_abnormal_mineral_homeostasis0.77644240
45MP0009763_increased_sensitivity_to0.76162863
46MP0003011_delayed_dark_adaptation0.70388580
47MP0003172_abnormal_lysosome_physiology0.69833537
48MP0004883_abnormal_blood_vessel0.67724183
49MP0005395_other_phenotype0.66937206
50MP0005164_abnormal_response_to0.64987698
51MP0003638_abnormal_response/metabolism_0.63737406
52MP0009764_decreased_sensitivity_to0.63026555
53MP0002168_other_aberrant_phenotype0.62445230
54MP0002089_abnormal_postnatal_growth/wei0.59934505
55MP0003329_amyloid_beta_deposits0.58918708
56MP0005670_abnormal_white_adipose0.58762374
57MP0003075_altered_response_to0.58115436
58MP0002078_abnormal_glucose_homeostasis0.57068672
59MP0000566_synostosis0.57067532
60MP0005187_abnormal_penis_morphology0.55805869
61MP0009785_altered_susceptibility_to0.52821446
62MP0000249_abnormal_blood_vessel0.52687619
63MP0003122_maternal_imprinting0.52474463
64MP0005334_abnormal_fat_pad0.51048964
65MP0005023_abnormal_wound_healing0.50338585
66MP0002282_abnormal_trachea_morphology0.45089273
67MP0005167_abnormal_blood-brain_barrier0.44875294
68MP0000920_abnormal_myelination0.44688044
69MP0005535_abnormal_body_temperature0.42399686
70MP0008874_decreased_physiological_sensi0.42035522
71MP0003436_decreased_susceptibility_to0.41865349
72MP0009115_abnormal_fat_cell0.39941612
73MP0005448_abnormal_energy_balance0.39289937
74MP0005084_abnormal_gallbladder_morpholo0.39036937
75MP0003632_abnormal_nervous_system0.34359791
76MP0005166_decreased_susceptibility_to0.33603688
77MP0000639_abnormal_adrenal_gland0.32171018
78MP0005220_abnormal_exocrine_pancreas0.32115454
79MP0005266_abnormal_metabolism0.31337931
80MP0003953_abnormal_hormone_level0.31207402
81MP0002136_abnormal_kidney_physiology0.31203527
82MP0002090_abnormal_vision0.30412351
83MP0001845_abnormal_inflammatory_respons0.29768210
84MP0002249_abnormal_larynx_morphology0.29727812
85MP0006036_abnormal_mitochondrial_physio0.29135071
86MP0001756_abnormal_urination0.28899486
87MP0005647_abnormal_sex_gland0.28736809
88MP0002419_abnormal_innate_immunity0.28263282
89MP0002970_abnormal_white_adipose0.26682144
90MP0004272_abnormal_basement_membrane0.25464695
91MP0005409_darkened_coat_color0.23609026
92MP0003633_abnormal_nervous_system0.23480023
93MP0005257_abnormal_intraocular_pressure0.23215151
94MP0003959_abnormal_lean_body0.23098499
95MP0002909_abnormal_adrenal_gland0.23062897
96MP0005197_abnormal_uvea_morphology0.22985048
97MP0000858_altered_metastatic_potential0.22790257
98MP0001851_eye_inflammation0.22654199
99MP0005083_abnormal_biliary_tract0.22629751
100MP0005025_abnormal_response_to0.22027569

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.38867387
2Prolonged partial thromboplastin time (HP:0003645)8.95565798
3Complement deficiency (HP:0004431)8.39012223
4Hypobetalipoproteinemia (HP:0003563)7.98229601
5Abnormality of aromatic amino acid family metabolism (HP:0004338)7.48945589
6Joint hemorrhage (HP:0005261)6.70063421
7Abnormality of complement system (HP:0005339)6.69971807
8Systemic lupus erythematosus (HP:0002725)6.49855425
9Glomerulonephritis (HP:0000099)5.67897573
10Xanthomatosis (HP:0000991)5.56321455
11Abnormality of the common coagulation pathway (HP:0010990)5.09581902
12Hyperlipoproteinemia (HP:0010980)5.04148363
13Conjugated hyperbilirubinemia (HP:0002908)4.96921026
14Hypolipoproteinemia (HP:0010981)4.76346393
15Intrahepatic cholestasis (HP:0001406)4.61803283
16Abnormality of pyrimidine metabolism (HP:0004353)4.54284989
17Spontaneous abortion (HP:0005268)4.16746136
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.91654355
19Nephritis (HP:0000123)3.78162267
20Recurrent gram-negative bacterial infections (HP:0005420)3.66954892
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.56001694
22Abnormality of the intrinsic pathway (HP:0010989)3.48091330
23Fat malabsorption (HP:0002630)3.41916401
24Hemorrhage of the eye (HP:0011885)3.36571279
25Hypercholesterolemia (HP:0003124)3.35401512
26Gingival bleeding (HP:0000225)3.26321061
27Hypoalphalipoproteinemia (HP:0003233)3.22708615
28Menorrhagia (HP:0000132)3.19223566
29Vascular calcification (HP:0004934)3.13250473
30Purpura (HP:0000979)3.13064659
31Mitral stenosis (HP:0001718)3.11433013
32Hyperglycinemia (HP:0002154)3.01377876
33Generalized aminoaciduria (HP:0002909)3.01170603
34Rickets (HP:0002748)2.97516637
35Hyperammonemia (HP:0001987)2.95758375
36Steatorrhea (HP:0002570)2.80434271
37Cardiovascular calcification (HP:0011915)2.75321547
38Epidermoid cyst (HP:0200040)2.69901265
39Delayed CNS myelination (HP:0002188)2.67909200
40Osteomalacia (HP:0002749)2.64769269
41Abnormality of methionine metabolism (HP:0010901)2.62149169
42Thrombophlebitis (HP:0004418)2.62023501
43Abnormality of glycine metabolism (HP:0010895)2.57253625
44Abnormality of serine family amino acid metabolism (HP:0010894)2.57253625
45Abnormality of nucleobase metabolism (HP:0010932)2.51287018
46Pulmonary embolism (HP:0002204)2.45701059
47Abnormal gallbladder physiology (HP:0012438)2.44122698
48Cholecystitis (HP:0001082)2.44122698
49Myocardial infarction (HP:0001658)2.38895261
50Hyperglycinuria (HP:0003108)2.37115278
51Reduced antithrombin III activity (HP:0001976)2.35143787
52Abnormality of the Achilles tendon (HP:0005109)2.33624076
53Hepatocellular carcinoma (HP:0001402)2.31497571
54Abnormality of serum amino acid levels (HP:0003112)2.26112084
55Arthropathy (HP:0003040)2.21671409
56Hypophosphatemic rickets (HP:0004912)2.10044295
57Hyperbilirubinemia (HP:0002904)2.08264745
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04572869
59Deep venous thrombosis (HP:0002625)11.1687849
60Bifid scrotum (HP:0000048)1.93112267
61Fair hair (HP:0002286)1.92808519
62Increased serum ferritin (HP:0003281)1.92672800
63Hydroxyprolinuria (HP:0003080)1.91649446
64Abnormality of proline metabolism (HP:0010907)1.91649446
65Hyperphosphaturia (HP:0003109)1.90131533
66Gangrene (HP:0100758)1.89595162
67Epistaxis (HP:0000421)1.86509570
68Abnormality of vitamin metabolism (HP:0100508)1.85074699
69Metabolic acidosis (HP:0001942)1.84795198
70Irritability (HP:0000737)1.84593195
71Retinal atrophy (HP:0001105)1.84182554
72Abnormality of iron homeostasis (HP:0011031)1.82997817
73Abnormality of urine glucose concentration (HP:0011016)1.81898249
74Glycosuria (HP:0003076)1.81898249
75Elevated alkaline phosphatase (HP:0003155)1.81863411
76Abnormality of sulfur amino acid metabolism (HP:0004339)1.80403056
77Joint swelling (HP:0001386)1.79558885
78Amyloidosis (HP:0011034)1.79463361
79Cholelithiasis (HP:0001081)1.78599652
80Skin nodule (HP:0200036)1.71510145
81Abnormal enzyme/coenzyme activity (HP:0012379)1.71251187
82Acanthocytosis (HP:0001927)1.70873182
83Poikilocytosis (HP:0004447)1.69059529
84Abnormal gallbladder morphology (HP:0012437)1.68379737
85Abnormality of transition element cation homeostasis (HP:0011030)1.67385480
86Abnormality of alkaline phosphatase activity (HP:0004379)1.67004543
87Enlarged kidneys (HP:0000105)1.62444793
88Urinary glycosaminoglycan excretion (HP:0003541)1.59907558
89Mucopolysacchariduria (HP:0008155)1.59907558
90Hypochromic microcytic anemia (HP:0004840)1.59761270
91Abnormality of purine metabolism (HP:0004352)1.58246281
92Abnormal urine phosphate concentration (HP:0012599)1.57434031
93Abnormal tarsal ossification (HP:0008369)1.56854811
94Hypophosphatemia (HP:0002148)1.56653505
95Sensorimotor neuropathy (HP:0007141)1.52972738
96Polycythemia (HP:0001901)1.51981992
97Abnormal platelet function (HP:0011869)1.51694981
98Impaired platelet aggregation (HP:0003540)1.51694981
99Ketosis (HP:0001946)1.51051424
100Potter facies (HP:0002009)1.49348975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.94131226
2ERN15.48661569
3RIPK13.36846308
4FGFR33.08206601
5TRIB32.84793440
6PIK3CG2.62602649
7ICK2.36099780
8TYK22.31430078
9PIK3CA2.27965661
10IRAK32.11846472
11SIK12.00405197
12MAP3K31.86896308
13BCKDK1.83555552
14MAPK111.76340194
15PRKACG1.76327213
16PRKAA21.68512044
17TBK11.67537275
18TGFBR21.59939439
19PDPK11.57541078
20NEK91.55155674
21NTRK31.39129921
22MAP3K21.34484428
23CSF1R1.34228658
24PRKCG1.29024162
25PDK21.27520282
26PKN21.26747634
27ABL21.23499634
28PRPF4B1.21688620
29PDGFRA1.19188258
30CAMK1D1.18989300
31FGFR21.15964364
32CDK121.15902359
33PDK11.12440157
34DYRK1B1.11009752
35BLK1.09662941
36CDK61.03558557
37ERBB21.01107828
38IGF1R0.99094525
39RET0.96411836
40MAP2K40.95243656
41MAP3K110.93492257
42WNK40.87630629
43JAK10.87565950
44ZAP700.87329889
45FGFR10.83094431
46MST1R0.82236514
47MAPKAPK30.81550136
48MAP3K10.81159298
49TAOK30.80420190
50PRKCZ0.79421626
51EPHA30.76581269
52MAP2K30.76271718
53PRKG10.73132955
54MAP3K120.72443373
55PRKAA10.71401354
56CAMKK20.70950849
57CSNK1D0.70548464
58JAK20.70340160
59EIF2AK10.70303280
60EPHA40.69671551
61SGK10.69423917
62CAMK1G0.60707846
63SGK4940.59835710
64SGK2230.59835710
65TAOK20.58969448
66KSR20.57377908
67PRKACA0.57347692
68PTK60.52722128
69SGK30.52058490
70MAP3K50.51590916
71CDK40.50926088
72CSNK1E0.50316536
73SRC0.49928932
74PRKCB0.49211010
75GSK3A0.48994021
76RPS6KA30.47956318
77SCYL20.46829972
78CDC42BPA0.45790321
79CSNK2A10.43843268
80AKT30.43052809
81CAMKK10.41557164
82MAP3K140.40970415
83TNK20.40838235
84ERBB40.40832139
85MTOR0.40154624
86PRKCA0.39841263
87CSNK2A20.39528080
88PIM20.39423138
89PRKACB0.38028873
90SIK20.37878865
91RPS6KB10.37857390
92MUSK0.37307543
93TYRO30.36587186
94SGK20.36167368
95MAPK120.33152672
96MAPK30.31523597
97MAP3K60.29985545
98NLK0.29481585
99LATS10.28679827
100MET0.28637376

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.38956199
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.12008473
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.99894173
4Caffeine metabolism_Homo sapiens_hsa002323.57460409
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50579652
6Retinol metabolism_Homo sapiens_hsa008303.17663130
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.15688534
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.85464453
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.79327113
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.76065043
11Chemical carcinogenesis_Homo sapiens_hsa052042.73267438
12Arginine biosynthesis_Homo sapiens_hsa002202.61796136
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.60354622
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.56317844
15Phenylalanine metabolism_Homo sapiens_hsa003602.35313614
16Fatty acid degradation_Homo sapiens_hsa000712.33941479
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17306199
18Tyrosine metabolism_Homo sapiens_hsa003502.01059831
19Butanoate metabolism_Homo sapiens_hsa006501.92219586
20Histidine metabolism_Homo sapiens_hsa003401.91357336
21Bile secretion_Homo sapiens_hsa049761.85963285
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.80745604
23Tryptophan metabolism_Homo sapiens_hsa003801.66819644
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63818667
25PPAR signaling pathway_Homo sapiens_hsa033201.62590753
26Starch and sucrose metabolism_Homo sapiens_hsa005001.61592664
27Staphylococcus aureus infection_Homo sapiens_hsa051501.58211289
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40714872
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40366580
30Peroxisome_Homo sapiens_hsa041461.39947651
31Linoleic acid metabolism_Homo sapiens_hsa005911.33881912
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.32353128
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.19618646
34beta-Alanine metabolism_Homo sapiens_hsa004101.19103068
35Biosynthesis of amino acids_Homo sapiens_hsa012301.14651596
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14365801
37Fat digestion and absorption_Homo sapiens_hsa049751.14006840
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11924292
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11520271
40Arginine and proline metabolism_Homo sapiens_hsa003301.08104839
41Pyruvate metabolism_Homo sapiens_hsa006201.05864796
42Prion diseases_Homo sapiens_hsa050201.05291153
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00052281
44Vitamin B6 metabolism_Homo sapiens_hsa007500.99360830
45Fatty acid metabolism_Homo sapiens_hsa012120.95609328
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93563005
47Arachidonic acid metabolism_Homo sapiens_hsa005900.90277568
48Carbon metabolism_Homo sapiens_hsa012000.90242177
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.89569031
50Propanoate metabolism_Homo sapiens_hsa006400.79345679
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78916012
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76762846
53ABC transporters_Homo sapiens_hsa020100.74034807
54Sulfur metabolism_Homo sapiens_hsa009200.69607579
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69127097
56One carbon pool by folate_Homo sapiens_hsa006700.67418175
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.59419888
58Sulfur relay system_Homo sapiens_hsa041220.59059270
59Other glycan degradation_Homo sapiens_hsa005110.56259669
60Lysine degradation_Homo sapiens_hsa003100.52844481
61Pertussis_Homo sapiens_hsa051330.47110061
62Steroid biosynthesis_Homo sapiens_hsa001000.46682822
63Vitamin digestion and absorption_Homo sapiens_hsa049770.46545470
64Metabolic pathways_Homo sapiens_hsa011000.42257291
65Fructose and mannose metabolism_Homo sapiens_hsa000510.41032970
66Fatty acid elongation_Homo sapiens_hsa000620.39988017
67Glycerolipid metabolism_Homo sapiens_hsa005610.34959652
68Galactose metabolism_Homo sapiens_hsa000520.27217473
69Insulin resistance_Homo sapiens_hsa049310.24397461
70Fatty acid biosynthesis_Homo sapiens_hsa000610.24369087
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23439280
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22802457
73Pentose phosphate pathway_Homo sapiens_hsa000300.21073577
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17067719
75Renin-angiotensin system_Homo sapiens_hsa046140.17001813
76Glutathione metabolism_Homo sapiens_hsa004800.16411447
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.12662283
78Glucagon signaling pathway_Homo sapiens_hsa049220.12543401
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07013986
80Systemic lupus erythematosus_Homo sapiens_hsa053220.06860832
81Mineral absorption_Homo sapiens_hsa049780.05883534
82Selenocompound metabolism_Homo sapiens_hsa004500.02625370
83Ether lipid metabolism_Homo sapiens_hsa00565-0.2076496
84Type II diabetes mellitus_Homo sapiens_hsa04930-0.1854802
85Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1792525
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1741560
87Serotonergic synapse_Homo sapiens_hsa04726-0.1531219
88Nitrogen metabolism_Homo sapiens_hsa00910-0.1468977
89Insulin signaling pathway_Homo sapiens_hsa04910-0.1402573
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1238519
91N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0636251
92Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0586451
93African trypanosomiasis_Homo sapiens_hsa05143-0.0530980
94Amoebiasis_Homo sapiens_hsa05146-0.0474155
95AMPK signaling pathway_Homo sapiens_hsa04152-0.0431773
96Folate biosynthesis_Homo sapiens_hsa00790-0.0398529
97Lysosome_Homo sapiens_hsa04142-0.0386800
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0335074
99Sphingolipid metabolism_Homo sapiens_hsa00600-0.0193407
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0153607

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »