APOE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.85303716
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.85303716
3L-phenylalanine metabolic process (GO:0006558)6.56049507
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.56049507
5* triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.43100526
6aromatic amino acid family catabolic process (GO:0009074)6.10269326
7alpha-linolenic acid metabolic process (GO:0036109)5.93904530
8indole-containing compound catabolic process (GO:0042436)5.52758200
9indolalkylamine catabolic process (GO:0046218)5.52758200
10tryptophan catabolic process (GO:0006569)5.52758200
11bile acid biosynthetic process (GO:0006699)5.50648935
12kynurenine metabolic process (GO:0070189)5.42510970
13* high-density lipoprotein particle remodeling (GO:0034375)5.37653727
14sulfur amino acid catabolic process (GO:0000098)5.29878427
15tryptophan metabolic process (GO:0006568)5.20106646
16urea metabolic process (GO:0019627)5.18826146
17urea cycle (GO:0000050)5.18826146
18negative regulation of fibrinolysis (GO:0051918)5.11914567
19glyoxylate metabolic process (GO:0046487)5.10839281
20complement activation, alternative pathway (GO:0006957)5.09508128
21* reverse cholesterol transport (GO:0043691)5.08150293
22peptidyl-glutamic acid carboxylation (GO:0017187)5.06230576
23protein carboxylation (GO:0018214)5.06230576
24regulation of cholesterol storage (GO:0010885)4.97103137
25cysteine metabolic process (GO:0006534)4.94063160
26regulation of protein activation cascade (GO:2000257)4.91899031
27regulation of fibrinolysis (GO:0051917)4.89016591
28* regulation of cholesterol esterification (GO:0010872)4.88762943
29* protein-lipid complex remodeling (GO:0034368)4.88318514
30* macromolecular complex remodeling (GO:0034367)4.88318514
31* plasma lipoprotein particle remodeling (GO:0034369)4.88318514
32regulation of triglyceride catabolic process (GO:0010896)4.77667904
33nitrogen cycle metabolic process (GO:0071941)4.76036726
34serine family amino acid catabolic process (GO:0009071)4.74556855
35glycosphingolipid catabolic process (GO:0046479)4.73182722
36bile acid metabolic process (GO:0008206)4.72753926
37oligosaccharide catabolic process (GO:0009313)4.72225994
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68139695
39regulation of complement activation (GO:0030449)4.60895770
40* phospholipid efflux (GO:0033700)4.60846710
41regulation of apoptotic cell clearance (GO:2000425)4.54065898
42amino-acid betaine metabolic process (GO:0006577)4.50083536
43homocysteine metabolic process (GO:0050667)4.49163978
44* low-density lipoprotein particle remodeling (GO:0034374)4.43594478
45aromatic amino acid family metabolic process (GO:0009072)4.39237768
46alpha-amino acid catabolic process (GO:1901606)4.35981045
47tyrosine metabolic process (GO:0006570)4.31770058
48positive regulation of fatty acid biosynthetic process (GO:0045723)4.30439595
49cellular ketone body metabolic process (GO:0046950)4.29199248
50lysine metabolic process (GO:0006553)4.26192168
51lysine catabolic process (GO:0006554)4.26192168
52* negative regulation of cholesterol transport (GO:0032375)4.25686379
53* negative regulation of sterol transport (GO:0032372)4.25686379
54* plasma lipoprotein particle clearance (GO:0034381)4.23890098
55acylglycerol homeostasis (GO:0055090)4.23471924
56triglyceride homeostasis (GO:0070328)4.23471924
57glycolipid catabolic process (GO:0019377)4.22129506
58cellular modified amino acid catabolic process (GO:0042219)4.19684541
59glutamate metabolic process (GO:0006536)4.16143773
60ethanol oxidation (GO:0006069)4.14310898
61fat-soluble vitamin biosynthetic process (GO:0042362)4.11917085
62* cholesterol efflux (GO:0033344)4.11244997
63cellular response to thyroid hormone stimulus (GO:0097067)4.10319280
64cellular amino acid catabolic process (GO:0009063)4.06338702
65dicarboxylic acid biosynthetic process (GO:0043650)4.03066693
66* plasma lipoprotein particle assembly (GO:0034377)4.00554246
67coenzyme catabolic process (GO:0009109)3.95640604
68amine catabolic process (GO:0009310)3.94267395
69cellular biogenic amine catabolic process (GO:0042402)3.94267395
70very-low-density lipoprotein particle assembly (GO:0034379)3.93822268
71cellular glucuronidation (GO:0052695)3.93143320
72bile acid and bile salt transport (GO:0015721)3.92815792
73low-density lipoprotein particle clearance (GO:0034383)3.92195811
74phospholipid homeostasis (GO:0055091)3.89513909
75glycine metabolic process (GO:0006544)3.87610669
76imidazole-containing compound metabolic process (GO:0052803)3.87357210
77indolalkylamine metabolic process (GO:0006586)3.84467150
78complement activation (GO:0006956)3.84171933
79* plasma lipoprotein particle organization (GO:0071827)3.84170546
80complement activation, classical pathway (GO:0006958)3.79454259
81amino sugar catabolic process (GO:0046348)3.77448307
82serine family amino acid metabolic process (GO:0009069)3.75802675
83ketone body metabolic process (GO:1902224)3.75237220
84negative regulation of lipase activity (GO:0060192)3.75083592
85arginine metabolic process (GO:0006525)3.74221100
86short-chain fatty acid metabolic process (GO:0046459)3.73791929
87protein activation cascade (GO:0072376)3.72350739
88regulation of cholesterol homeostasis (GO:2000188)3.70859567
89positive regulation of lipid catabolic process (GO:0050996)3.70280044
90serine family amino acid biosynthetic process (GO:0009070)3.68682852
91ceramide catabolic process (GO:0046514)3.68586302
92benzene-containing compound metabolic process (GO:0042537)3.68450549
93fibrinolysis (GO:0042730)3.68031691
94response to thyroid hormone (GO:0097066)3.64507183
95positive regulation of lipoprotein lipase activity (GO:0051006)3.61492575
96positive regulation of triglyceride lipase activity (GO:0061365)3.61492575
97* protein-lipid complex subunit organization (GO:0071825)3.61055771
98carboxylic acid catabolic process (GO:0046395)3.58314941
99organic acid catabolic process (GO:0016054)3.58314941
100* protein-lipid complex assembly (GO:0065005)3.57835971
101regulation of macrophage chemotaxis (GO:0010758)3.57550551
102linoleic acid metabolic process (GO:0043651)3.55868370
103regulation of mononuclear cell migration (GO:0071675)3.54885118
104drug catabolic process (GO:0042737)3.54561754
105apoptotic cell clearance (GO:0043277)3.54425543
106cofactor catabolic process (GO:0051187)3.53688577
107glucuronate metabolic process (GO:0019585)3.46545730
108uronic acid metabolic process (GO:0006063)3.46545730
109* cholesterol homeostasis (GO:0042632)3.46395501
110blood coagulation, intrinsic pathway (GO:0007597)3.45307417
111regulation of bile acid biosynthetic process (GO:0070857)3.45035242
112positive regulation of fatty acid beta-oxidation (GO:0032000)3.44571731
113positive regulation of triglyceride metabolic process (GO:0090208)3.43707060
114carnitine metabolic process (GO:0009437)3.43203926
115detection of molecule of bacterial origin (GO:0032490)3.42844948
116* sterol homeostasis (GO:0055092)3.40143653
117regulation of lipoprotein particle clearance (GO:0010984)3.32676337
118N-acetylneuraminate metabolic process (GO:0006054)3.27560656
119regulation of fatty acid biosynthetic process (GO:0042304)3.25159405
120* positive regulation of steroid metabolic process (GO:0045940)3.25126375
121* positive regulation of cholesterol efflux (GO:0010875)3.20354369
122* negative regulation of lipid transport (GO:0032369)3.19356337
123chondroitin sulfate catabolic process (GO:0030207)3.17315517
124* regulation of sterol transport (GO:0032371)3.14370800
125* regulation of cholesterol transport (GO:0032374)3.14370800
126* lipoprotein metabolic process (GO:0042157)3.13168213
127positive regulation of hemostasis (GO:1900048)3.10402100
128positive regulation of blood coagulation (GO:0030194)3.10402100
129negative regulation of fatty acid biosynthetic process (GO:0045717)3.07305146
130positive regulation of coagulation (GO:0050820)3.05576111
131* sterol transport (GO:0015918)3.00873838
132* cholesterol transport (GO:0030301)3.00873838
133barbed-end actin filament capping (GO:0051016)3.00778999
134acute-phase response (GO:0006953)2.99346698
135positive regulation of phagocytosis (GO:0050766)2.97938029
136omega-hydroxylase P450 pathway (GO:0097267)2.95026308
137cellular response to cadmium ion (GO:0071276)2.94166072
138epoxygenase P450 pathway (GO:0019373)2.89180699
139sphingolipid catabolic process (GO:0030149)2.84773672
140regulation of superoxide anion generation (GO:0032928)2.82608444
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.82307781
142membrane lipid catabolic process (GO:0046466)2.82020094
143regulation of plasminogen activation (GO:0010755)2.77443493
144positive regulation of lipid storage (GO:0010884)2.76717784
145* positive regulation of cholesterol transport (GO:0032376)2.74044281
146* positive regulation of sterol transport (GO:0032373)2.74044281
147vitamin D metabolic process (GO:0042359)2.68851710
148positive regulation of extracellular matrix organization (GO:1903055)2.67437256
149* negative regulation of blood coagulation (GO:0030195)2.64935964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.61237766
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.50127714
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.01695141
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.98292136
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.12369930
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80220976
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.20390010
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.65384513
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.28681928
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.45556080
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.23540412
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03220066
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8640075
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91152555
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86857794
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77195728
17CLOCK_20551151_ChIP-Seq_293T_Human1.69168568
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63340615
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.53836089
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53038337
21KDM2B_26808549_Chip-Seq_K562_Human1.52378847
22VDR_21846776_ChIP-Seq_THP-1_Human1.46104973
23GATA1_22025678_ChIP-Seq_K562_Human1.41782451
24HTT_18923047_ChIP-ChIP_STHdh_Human1.41448493
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41362279
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36745491
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34781550
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.32308985
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30209918
30VDR_24787735_ChIP-Seq_THP-1_Human1.29605759
31NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27789831
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27562401
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26129496
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24884834
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24287908
36VDR_24763502_ChIP-Seq_THP-1_Human1.21417443
37HNF4A_19822575_ChIP-Seq_HepG2_Human1.20974137
38SPI1_23127762_ChIP-Seq_K562_Human1.17679414
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17475049
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17323933
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16828672
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16778923
43* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16467298
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10182736
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09718037
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09678217
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.09259593
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.08377324
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08066994
50RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07040254
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05882840
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04667122
53SMC4_20622854_ChIP-Seq_HELA_Human1.04354694
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04064884
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03177747
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02124952
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01822710
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00377517
59KDM2B_26808549_Chip-Seq_DND41_Human1.00118577
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00105709
61SCL_19346495_ChIP-Seq_HPC-7_Human0.99687571
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99606511
63IRF8_22096565_ChIP-ChIP_GC-B_Human0.98894339
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96322637
65* TCF7_22412390_ChIP-Seq_EML_Mouse0.95467146
66* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95100063
67LXR_22292898_ChIP-Seq_THP-1_Human0.92767934
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91754668
69P68_20966046_ChIP-Seq_HELA_Human0.91326994
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90150512
71TBX20_22080862_ChIP-Seq_HEART_Mouse0.89726778
72TBX20_22328084_ChIP-Seq_HEART_Mouse0.89726778
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89497843
74GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89365249
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89208088
76MITF_21258399_ChIP-Seq_MELANOMA_Human0.88588459
77SA1_27219007_Chip-Seq_ERYTHROID_Human0.88428129
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88001974
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86471778
80JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86437156
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86089857
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85023920
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84767970
84DROSHA_22980978_ChIP-Seq_HELA_Human0.83334643
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83304355
86ERG_21242973_ChIP-ChIP_JURKAT_Human0.83092760
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78217517
88RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77670657
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76609408
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74686321
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74686321
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72763119
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71973335
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69740501
95EGR1_19032775_ChIP-ChIP_M12_Human0.69033494
96* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68649359
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68490875
98* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68241547
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68189660
100GATA1_19941826_ChIP-Seq_K562_Human0.67896704
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65947626
102BCAT_22108803_ChIP-Seq_LS180_Human0.65575837
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63807817
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.63691370
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63563805
106IRF8_27001747_Chip-Seq_BMDM_Mouse0.63442488
107GATA4_25053715_ChIP-Seq_YYC3_Human0.63078945
108* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62450185
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61851884
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60314533
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60085499
112* GATA1_19941827_ChIP-Seq_MEL_Mouse0.59643969
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.59178765
114ZNF263_19887448_ChIP-Seq_K562_Human0.58317214
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57947507
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.57568906
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.57440551
118GATA2_19941826_ChIP-Seq_K562_Human0.57067530
119CEBPB_22108803_ChIP-Seq_LS180_Human0.56591492
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.56368379
121TAF2_19829295_ChIP-Seq_ESCs_Human0.56279553
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.55941637
123* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54266465
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.52981544
125MYC_19915707_ChIP-ChIP_AK7_Human0.52261723
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.51700808
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51139048
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.49896929
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.49402558
130CBP_21632823_ChIP-Seq_H3396_Human0.48571721
131AR_20517297_ChIP-Seq_VCAP_Human0.46800170
132* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.46680288
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46444325
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.45891706
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.45728047
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.45279957
137RARB_24833708_ChIP-Seq_LIVER_Mouse0.44059453
138P53_21459846_ChIP-Seq_SAOS-2_Human0.43655927
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.43393096
140BCOR_27268052_Chip-Seq_Bcells_Human0.42987921
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.42320506
142* CTCF_27219007_Chip-Seq_Bcells_Human0.41703569
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.41279250
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40877950
145RACK7_27058665_Chip-Seq_MCF-7_Human0.40753149
146P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.40710112
147BCL6_27268052_Chip-Seq_Bcells_Human0.40215550
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.39524463
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.39003020
150SPI1_20517297_ChIP-Seq_HL60_Human0.38966601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.92925908
2MP0005360_urolithiasis6.90342950
3MP0005085_abnormal_gallbladder_physiolo5.94634257
4MP0005365_abnormal_bile_salt5.91433483
5MP0008875_abnormal_xenobiotic_pharmacok4.91053347
6MP0003806_abnormal_nucleotide_metabolis3.84065962
7* MP0010329_abnormal_lipoprotein_level3.65347539
8* MP0009840_abnormal_foam_cell3.57868929
9MP0003252_abnormal_bile_duct3.55937769
10MP0005083_abnormal_biliary_tract2.91144691
11MP0003191_abnormal_cellular_cholesterol2.83538111
12* MP0005332_abnormal_amino_acid2.76603116
13MP0003195_calcinosis2.59120104
14MP0003303_peritoneal_inflammation2.56091142
15MP0001666_abnormal_nutrient_absorption2.42240921
16MP0002254_reproductive_system_inflammat2.30089473
17* MP0002118_abnormal_lipid_homeostasis2.19372852
18* MP0000609_abnormal_liver_physiology2.16215747
19MP0003011_delayed_dark_adaptation2.02775194
20MP0000920_abnormal_myelination2.02315696
21* MP0004019_abnormal_vitamin_homeostasis1.96190687
22MP0005257_abnormal_intraocular_pressure1.86416003
23* MP0005319_abnormal_enzyme/_coenzyme1.74602675
24MP0002138_abnormal_hepatobiliary_system1.65833889
25MP0009278_abnormal_bone_marrow1.64374919
26* MP0005584_abnormal_enzyme/coenzyme_acti1.64004586
27MP0003868_abnormal_feces_composition1.57388272
28* MP0002998_abnormal_bone_remodeling1.55931420
29* MP0000343_altered_response_to1.55857790
30MP0003879_abnormal_hair_cell1.53576493
31MP0001764_abnormal_homeostasis1.51696814
32* MP0003690_abnormal_glial_cell1.51203253
33MP0009785_altered_susceptibility_to1.49146936
34* MP0000604_amyloidosis1.46157046
35* MP0003634_abnormal_glial_cell1.44025391
36MP0009697_abnormal_copulation1.43614938
37MP0003453_abnormal_keratinocyte_physiol1.40921255
38MP0003705_abnormal_hypodermis_morpholog1.40306302
39* MP0002148_abnormal_hypersensitivity_rea1.37238619
40MP0005058_abnormal_lysosome_morphology1.34600135
41* MP0003632_abnormal_nervous_system1.33153264
42MP0003656_abnormal_erythrocyte_physiolo1.31840142
43MP0004510_myositis1.29638424
44MP0005397_hematopoietic_system_phenotyp1.26277677
45MP0001545_abnormal_hematopoietic_system1.26277677
46MP0005647_abnormal_sex_gland1.25447915
47MP0005670_abnormal_white_adipose1.23454054
48MP0005451_abnormal_body_composition1.23140268
49* MP0009643_abnormal_urine_homeostasis1.18289105
50* MP0005025_abnormal_response_to1.16532682
51* MP0009764_decreased_sensitivity_to1.14849448
52* MP0001533_abnormal_skeleton_physiology1.12749529
53MP0000598_abnormal_liver_morphology1.10302275
54MP0001915_intracranial_hemorrhage1.10179810
55MP0008260_abnormal_autophagy1.09976756
56* MP0003186_abnormal_redox_activity1.07885628
57MP0004130_abnormal_muscle_cell1.07675667
58MP0005171_absent_coat_pigmentation1.03224022
59* MP0009763_increased_sensitivity_to1.00387306
60MP0003136_yellow_coat_color0.98319890
61MP0003183_abnormal_peptide_metabolism0.97622238
62MP0000858_altered_metastatic_potential0.96878912
63* MP0008469_abnormal_protein_level0.96347616
64* MP0003075_altered_response_to0.94894857
65* MP0009642_abnormal_blood_homeostasis0.90009605
66MP0010368_abnormal_lymphatic_system0.86994240
67MP0000371_diluted_coat_color0.86500013
68MP0001849_ear_inflammation0.86190358
69MP0005636_abnormal_mineral_homeostasis0.85839690
70* MP0005000_abnormal_immune_tolerance0.85036699
71MP0003448_altered_tumor_morphology0.82320417
72* MP0005387_immune_system_phenotype0.81967433
73* MP0001790_abnormal_immune_system0.81967433
74* MP0003329_amyloid_beta_deposits0.81056233
75MP0002089_abnormal_postnatal_growth/wei0.80935270
76MP0005535_abnormal_body_temperature0.79362243
77MP0005464_abnormal_platelet_physiology0.79071069
78MP0005167_abnormal_blood-brain_barrier0.78535514
79MP0005671_abnormal_response_to0.77422358
80* MP0002078_abnormal_glucose_homeostasis0.74579612
81* MP0002452_abnormal_antigen_presenting0.73405809
82MP0005023_abnormal_wound_healing0.71706444
83MP0003828_pulmonary_edema0.71704395
84* MP0001853_heart_inflammation0.71638079
85* MP0002971_abnormal_brown_adipose0.70849850
86* MP0005376_homeostasis/metabolism_phenot0.70672974
87MP0002090_abnormal_vision0.70330386
88MP0003091_abnormal_cell_migration0.70184246
89* MP0005334_abnormal_fat_pad0.69660269
90* MP0005595_abnormal_vascular_smooth0.68878302
91MP0008874_decreased_physiological_sensi0.67661484
92MP0009765_abnormal_xenobiotic_induced0.66496943
93MP0002876_abnormal_thyroid_physiology0.64069237
94MP0002877_abnormal_melanocyte_morpholog0.63677848
95MP0002896_abnormal_bone_mineralization0.63661923
96MP0001756_abnormal_urination0.62919820
97MP0001835_abnormal_antigen_presentation0.62884896
98MP0003436_decreased_susceptibility_to0.61786081
99MP0002822_catalepsy0.60973265
100* MP0005164_abnormal_response_to0.60822415
101MP0003724_increased_susceptibility_to0.60812208
102MP0008004_abnormal_stomach_pH0.59662660
103MP0009384_cardiac_valve_regurgitation0.59658738
104MP0002933_joint_inflammation0.59467866
105MP0006036_abnormal_mitochondrial_physio0.58733218
106* MP0004947_skin_inflammation0.58641378
107* MP0005166_decreased_susceptibility_to0.56827976
108MP0005666_abnormal_adipose_tissue0.56218602
109* MP0000639_abnormal_adrenal_gland0.54989126
110MP0005084_abnormal_gallbladder_morpholo0.53171668
111* MP0003638_abnormal_response/metabolism_0.52659665
112MP0006082_CNS_inflammation0.52420436
113MP0005266_abnormal_metabolism0.52096523
114MP0001661_extended_life_span0.50287491
115* MP0002136_abnormal_kidney_physiology0.49698532
116MP0003172_abnormal_lysosome_physiology0.49381713
117* MP0005448_abnormal_energy_balance0.49209113
118MP0005408_hypopigmentation0.47214418
119MP0008872_abnormal_physiological_respon0.45579725
120MP0009053_abnormal_anal_canal0.44805386
121MP0008873_increased_physiological_sensi0.43462745
122* MP0003953_abnormal_hormone_level0.43194300
123* MP0003633_abnormal_nervous_system0.42845786
124* MP0000249_abnormal_blood_vessel0.42784787
125MP0005395_other_phenotype0.41620206
126MP0002796_impaired_skin_barrier0.41065503
127MP0001881_abnormal_mammary_gland0.41060330
128MP0003300_gastrointestinal_ulcer0.40721145
129MP0002295_abnormal_pulmonary_circulatio0.40596194
130* MP0002419_abnormal_innate_immunity0.40592408
131MP0002168_other_aberrant_phenotype0.39694490
132MP0004858_abnormal_nervous_system0.39656093
133MP0004782_abnormal_surfactant_physiolog0.39295210
134* MP0009115_abnormal_fat_cell0.39016737
135MP0000579_abnormal_nail_morphology0.38823557
136MP0002132_abnormal_respiratory_system0.36437737
137MP0005248_abnormal_Harderian_gland0.36237688
138* MP0001845_abnormal_inflammatory_respons0.36016718
139MP0005220_abnormal_exocrine_pancreas0.34659016
140MP0004885_abnormal_endolymph0.33482777
141* MP0003631_nervous_system_phenotype0.32938710
142* MP0000230_abnormal_systemic_arterial0.30882213
143MP0006035_abnormal_mitochondrial_morpho0.30827404
144MP0002928_abnormal_bile_duct0.29840773

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.32968001
2Abnormality of liposaccharide metabolism (HP:0010968)7.32968001
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.32968001
4Deep venous thrombosis (HP:0002625)6.99031167
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.72592094
6Intrahepatic cholestasis (HP:0001406)6.55715701
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.12303858
8Prolonged partial thromboplastin time (HP:0003645)6.05817808
9* Xanthomatosis (HP:0000991)5.96134681
10Complement deficiency (HP:0004431)5.80976989
11Hyperlipoproteinemia (HP:0010980)5.74617596
12Hypobetalipoproteinemia (HP:0003563)5.71947511
13Increased cerebral lipofuscin (HP:0011813)4.94828716
14Hypolipoproteinemia (HP:0010981)4.77026119
15Joint hemorrhage (HP:0005261)4.74425538
16Hypoalphalipoproteinemia (HP:0003233)4.65690104
17Hyperammonemia (HP:0001987)4.49544584
18Vacuolated lymphocytes (HP:0001922)4.48796644
19Hyperglycinemia (HP:0002154)4.36584589
20Abnormality of complement system (HP:0005339)4.35435354
21Dysostosis multiplex (HP:0000943)4.33949370
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.30432098
23Epidermoid cyst (HP:0200040)4.29606560
24Systemic lupus erythematosus (HP:0002725)4.19251218
25Abnormality of methionine metabolism (HP:0010901)4.18047665
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.13990481
27Hyperglycinuria (HP:0003108)4.13709331
28Abnormality of the common coagulation pathway (HP:0010990)4.11038978
29Ketosis (HP:0001946)4.10959961
30Abnormality of serine family amino acid metabolism (HP:0010894)4.04891231
31Abnormality of glycine metabolism (HP:0010895)4.04891231
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.98450607
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.90910095
34Retinal atrophy (HP:0001105)3.80143822
35Increased neuronal autofluorescent lipopigment (HP:0002074)3.76438039
36Hypoglycemic coma (HP:0001325)3.64832077
37Fat malabsorption (HP:0002630)3.63696563
38Glomerulonephritis (HP:0000099)3.62385975
39Abnormality of mucopolysaccharide metabolism (HP:0011020)3.54063933
40Abnormality of polysaccharide metabolism (HP:0011012)3.54063933
41Abnormality of glycosaminoglycan metabolism (HP:0004371)3.54063933
42Mucopolysacchariduria (HP:0008155)3.52238608
43Urinary glycosaminoglycan excretion (HP:0003541)3.52238608
44Loss of speech (HP:0002371)3.45452085
45Purpura (HP:0000979)3.43619525
46Myocardial infarction (HP:0001658)3.37778274
47Abnormality of pyrimidine metabolism (HP:0004353)3.35020216
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32132770
49Disinhibition (HP:0000734)3.27759841
50Delayed CNS myelination (HP:0002188)3.26846149
51Abnormality of the intrinsic pathway (HP:0010989)3.26184590
52Abnormality of fatty-acid metabolism (HP:0004359)3.25792142
53* Hypercholesterolemia (HP:0003124)3.24325381
54* Neurofibrillary tangles (HP:0002185)3.23140129
55Conjugated hyperbilirubinemia (HP:0002908)3.14039608
56Mutism (HP:0002300)3.10841063
57Hyperbilirubinemia (HP:0002904)3.06914753
58Ketoacidosis (HP:0001993)3.06092290
59Abnormality of macrophages (HP:0004311)3.02103839
60Eczematoid dermatitis (HP:0000976)2.98940693
61Amyloidosis (HP:0011034)2.92877968
62Abnormality of serum amino acid levels (HP:0003112)2.90469284
63Abnormality of the periventricular white matter (HP:0002518)2.81284581
64Steatorrhea (HP:0002570)2.75723510
65Skin nodule (HP:0200036)2.72507185
66Abnormality of nucleobase metabolism (HP:0010932)2.72144602
67Hepatocellular carcinoma (HP:0001402)2.60953700
68Vascular calcification (HP:0004934)2.59958418
69Spontaneous abortion (HP:0005268)2.54377301
70Mitral stenosis (HP:0001718)2.52899419
71Metabolic acidosis (HP:0001942)2.49705504
72Nuclear cataract (HP:0100018)2.49389277
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49319530
74Dicarboxylic aciduria (HP:0003215)2.49319530
75Sensorimotor neuropathy (HP:0007141)2.47876848
76Neuronal loss in central nervous system (HP:0002529)2.44730328
77Hypoglycemic seizures (HP:0002173)2.42288410
78Abnormality of purine metabolism (HP:0004352)2.40706795
79* Cerebral inclusion bodies (HP:0100314)2.39028731
80Nephritis (HP:0000123)2.37896090
81Pathologic fracture (HP:0002756)2.36789234
82Lethargy (HP:0001254)2.36246767
83Peripheral demyelination (HP:0011096)2.35980163
84Apathy (HP:0000741)2.34773155
85Irritability (HP:0000737)2.34324303
86Esophageal varix (HP:0002040)2.32498125
87Cardiovascular calcification (HP:0011915)2.28466164
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28439829
89Abnormal gallbladder morphology (HP:0012437)2.26694017
90Recurrent gram-negative bacterial infections (HP:0005420)2.26631899
91Abnormal gallbladder physiology (HP:0012438)2.26461148
92Cholecystitis (HP:0001082)2.26461148
93Hypochromic microcytic anemia (HP:0004840)2.23868769
94Diminished motivation (HP:0000745)2.23694919
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23303528
96Spastic diplegia (HP:0001264)2.23083759
97Cholelithiasis (HP:0001081)2.22963565
98Neonatal onset (HP:0003623)2.20888361
99Abnormality of the vasculature of the conjunctiva (HP:0008054)2.19982378
100Abnormality of proline metabolism (HP:0010907)2.16237016
101Hydroxyprolinuria (HP:0003080)2.16237016
102Recurrent abscess formation (HP:0002722)2.16200640
103Status epilepticus (HP:0002133)2.15616354
104* Dementia (HP:0000726)2.14996405
105Acanthocytosis (HP:0001927)2.13621271
106Gingival bleeding (HP:0000225)2.11373945
107Back pain (HP:0003418)2.08875817
108Recurrent bacterial skin infections (HP:0005406)2.08172552
109Malnutrition (HP:0004395)2.06513210
110Gout (HP:0001997)2.06315907
111Vertebral compression fractures (HP:0002953)2.06184842
112Pancreatitis (HP:0001733)2.06147543
113Increased CSF protein (HP:0002922)2.03858425
114Supranuclear gaze palsy (HP:0000605)2.01810969
115Brushfield spots (HP:0001088)2.01683809
116Menorrhagia (HP:0000132)2.00263408
117Increased serum ferritin (HP:0003281)1.99002974
118Orchitis (HP:0100796)1.98329979
119Thrombophlebitis (HP:0004418)1.98283044
120J-shaped sella turcica (HP:0002680)1.95743531
121Autoimmune thrombocytopenia (HP:0001973)1.94222800
122Progressive neurologic deterioration (HP:0002344)1.93327192
123Vomiting (HP:0002013)1.93309667
124Hepatosplenomegaly (HP:0001433)1.93092143
125Axonal loss (HP:0003447)1.92198171
126Cerebral edema (HP:0002181)1.92078826
127Hemorrhage of the eye (HP:0011885)1.90030460
128Peripheral hypomyelination (HP:0007182)1.86795878
129Bone pain (HP:0002653)1.86525930
130Abnormality of iron homeostasis (HP:0011031)1.86498626
131Abnormality of the Achilles tendon (HP:0005109)1.86194230
132Generalized aminoaciduria (HP:0002909)1.85747230
133Enlarged kidneys (HP:0000105)1.85095182
134Global brain atrophy (HP:0002283)1.84119262
135Asymmetric septal hypertrophy (HP:0001670)1.83931852
136Retrobulbar optic neuritis (HP:0100654)1.82434053
137Optic neuritis (HP:0100653)1.82434053
138Hyperinsulinemic hypoglycemia (HP:0000825)1.82211603
139Abnormality of the gallbladder (HP:0005264)1.82191755
140Stroke (HP:0001297)1.79931222
141Opisthotonus (HP:0002179)1.79795650
142Abnormality of transition element cation homeostasis (HP:0011030)1.78721116
143Agnosia (HP:0010524)1.78359398
144Metaphyseal irregularity (HP:0003025)1.77530535
145Pseudobulbar signs (HP:0002200)1.76851187
146Multiple enchondromatosis (HP:0005701)1.76806233
147Thoracic kyphosis (HP:0002942)1.75766447
148Upper motor neuron abnormality (HP:0002127)1.75429867
149Personality changes (HP:0000751)1.75116820
150Rickets (HP:0002748)1.75084915
151Cardiomegaly (HP:0001640)1.73547767
152Hypophosphatemic rickets (HP:0004912)1.72192813
153Protuberant abdomen (HP:0001538)1.71649599
154Cerebral aneurysm (HP:0004944)1.69980187
155Abnormality of the lumbar spine (HP:0100712)1.69083808
156Inappropriate behavior (HP:0000719)1.68731342
157Gingivitis (HP:0000230)1.68460944
158Abnormality of vitamin metabolism (HP:0100508)1.68349800
159Elevated hepatic transaminases (HP:0002910)1.67817014
160Paraparesis (HP:0002385)1.66592161
161Polycythemia (HP:0001901)1.66073793
162Pulmonary embolism (HP:0002204)1.65528932
163Prolonged neonatal jaundice (HP:0006579)1.65436985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.77893952
2SIK14.70721792
3ERN14.11994122
4FGFR43.44371609
5DDR23.20713978
6TRIB32.51466507
7EPHA42.48561286
8NME22.39765308
9PRPF4B2.16522555
10TAOK32.11655626
11TYRO32.10948488
12INSRR2.07267485
13LMTK22.06473875
14MST1R1.99038522
15DAPK21.94398343
16PDGFRA1.89889465
17TYK21.88894580
18MAP2K41.85799885
19PKN21.82338090
20ICK1.71775853
21TGFBR21.69939958
22ERBB41.64445371
23CAMK1D1.61408312
24ACVR1B1.53186701
25PIK3CG1.47529783
26NTRK31.46006712
27PINK11.45162616
28IRAK31.44412835
29PTK61.44226871
30MAPK111.42420663
31GRK61.34178534
32JAK21.31510244
33MAPK121.28538836
34TBK11.25070471
35PDK21.24913521
36CDC42BPA1.21324640
37PHKG21.16350718
38PHKG11.16350718
39EPHB11.15376366
40JAK11.14854761
41RIPK11.12441615
42FES1.05729627
43MAP3K71.05454040
44ABL21.03968026
45MET1.02848844
46NEK91.01808093
47PRKAA21.00444131
48MAPK40.99282380
49BLK0.98613810
50FGFR20.96940590
51SGK30.96829026
52MAP3K140.95874770
53LATS20.95852603
54CAMKK20.95073565
55FLT30.94838610
56MAP3K130.93449536
57CAMK1G0.90635257
58KDR0.89732954
59ARAF0.83940743
60BMX0.82921568
61RIPK40.82424084
62PKN10.82080410
63ZAP700.81741275
64SGK20.80783154
65PRKACG0.80670958
66PRKCG0.79940055
67NTRK20.79203081
68CAMKK10.78781117
69PRKCZ0.78276334
70PIM20.77428138
71MAPK70.76474813
72PAK40.73697086
73RPS6KA20.69154527
74CDK60.68996282
75SGK2230.68022398
76SGK4940.68022398
77MAPK150.67097821
78ERBB20.66568416
79CSF1R0.65743294
80MARK20.65047782
81IGF1R0.64894497
82PDGFRB0.64875581
83CSK0.64000998
84MOS0.63807620
85TESK10.62768938
86CAMK2G0.60122058
87NTRK10.59567703
88RET0.59048580
89PDPK10.58577903
90JAK30.56620838
91FGFR30.56476062
92PRKG20.56439154
93KSR20.53257430
94SMG10.53209687
95LATS10.53057480
96IKBKE0.52752888
97TIE10.52130824
98ALK0.51832017
99PTK20.51312265
100STK380.51108535
101RPS6KC10.50992765
102RPS6KL10.50992765
103CAMK2B0.50795338
104CAMK40.49585355
105PRKAA10.48902012
106MAP2K10.48667135
107KIT0.48581645
108MAP2K30.48333379
109GSK3A0.48200547
110IKBKB0.46906823
111MAP2K60.46512208
112DYRK1B0.46470886
113MAP3K20.45894613
114SIK20.45442099
115EPHA30.44859151
116EGFR0.44775564
117PDK10.44566070
118GRK70.43963901
119PRKCQ0.43922843
120LYN0.43566276
121IRAK20.43174763
122ROCK20.42945692
123SRC0.42612868
124SGK10.42045252
125PAK60.41829322
126EEF2K0.41222143
127MAP3K30.40543191
128IRAK10.39353286
129MAP3K110.39327471
130PRKCA0.37923526
131FGR0.35552780
132MAP3K10.33593791
133TNK20.32512872
134MATK0.32414164
135MAP2K20.31103671
136FRK0.30315173
137PRKD10.28106423
138TAOK20.27550971

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26788648
2Nitrogen metabolism_Homo sapiens_hsa009104.20053721
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17725175
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99265574
5Arginine biosynthesis_Homo sapiens_hsa002202.96178384
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.90380310
7Complement and coagulation cascades_Homo sapiens_hsa046102.82788626
8Fatty acid degradation_Homo sapiens_hsa000712.67526232
9Tryptophan metabolism_Homo sapiens_hsa003802.48669491
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45132612
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38353610
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33701388
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21776983
14Staphylococcus aureus infection_Homo sapiens_hsa051502.21226033
15PPAR signaling pathway_Homo sapiens_hsa033202.08656188
16Fatty acid metabolism_Homo sapiens_hsa012122.08143447
17Butanoate metabolism_Homo sapiens_hsa006502.06473500
18Peroxisome_Homo sapiens_hsa041462.05460208
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02155205
20Propanoate metabolism_Homo sapiens_hsa006401.94870887
21Chemical carcinogenesis_Homo sapiens_hsa052041.88340659
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83206934
23Histidine metabolism_Homo sapiens_hsa003401.77760463
24Caffeine metabolism_Homo sapiens_hsa002321.77180273
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.71154053
26beta-Alanine metabolism_Homo sapiens_hsa004101.68622432
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67230881
28Retinol metabolism_Homo sapiens_hsa008301.58398222
29Bile secretion_Homo sapiens_hsa049761.57108656
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56904389
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.56234821
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43839420
33Rheumatoid arthritis_Homo sapiens_hsa053231.42740358
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38595979
35Phenylalanine metabolism_Homo sapiens_hsa003601.37101360
36Selenocompound metabolism_Homo sapiens_hsa004501.35104174
37Fatty acid elongation_Homo sapiens_hsa000621.30193578
38Starch and sucrose metabolism_Homo sapiens_hsa005001.29936724
39Pyruvate metabolism_Homo sapiens_hsa006201.26393864
40Tyrosine metabolism_Homo sapiens_hsa003501.26017631
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25555010
42Osteoclast differentiation_Homo sapiens_hsa043801.22958026
43ABC transporters_Homo sapiens_hsa020101.22830083
44Steroid biosynthesis_Homo sapiens_hsa001001.22449628
45Sulfur metabolism_Homo sapiens_hsa009201.22279630
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19924796
47Fatty acid biosynthesis_Homo sapiens_hsa000611.19339719
48Phagosome_Homo sapiens_hsa041451.19291485
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18413952
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17200905
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.16517856
52Carbon metabolism_Homo sapiens_hsa012001.10090846
53Fat digestion and absorption_Homo sapiens_hsa049751.09987983
54Folate biosynthesis_Homo sapiens_hsa007901.04072207
55Leishmaniasis_Homo sapiens_hsa051401.00974034
56Arginine and proline metabolism_Homo sapiens_hsa003300.96161774
57Sphingolipid metabolism_Homo sapiens_hsa006000.95930746
58Tuberculosis_Homo sapiens_hsa051520.94835740
59Sulfur relay system_Homo sapiens_hsa041220.94586658
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92903221
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92107268
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91252736
63Vitamin digestion and absorption_Homo sapiens_hsa049770.85392783
64Collecting duct acid secretion_Homo sapiens_hsa049660.84853091
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84514012
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.83321173
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83238858
68Glycerolipid metabolism_Homo sapiens_hsa005610.76604592
69Vitamin B6 metabolism_Homo sapiens_hsa007500.75513139
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72141585
71Lysine degradation_Homo sapiens_hsa003100.71992617
72Vibrio cholerae infection_Homo sapiens_hsa051100.71600160
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.66840651
74Asthma_Homo sapiens_hsa053100.62099022
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60778088
76Pentose phosphate pathway_Homo sapiens_hsa000300.60705051
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60202478
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57778188
79Amoebiasis_Homo sapiens_hsa051460.55392548
80Salmonella infection_Homo sapiens_hsa051320.54641399
81Glutathione metabolism_Homo sapiens_hsa004800.53002271
82Prion diseases_Homo sapiens_hsa050200.51726893
83Synaptic vesicle cycle_Homo sapiens_hsa047210.50082852
84Allograft rejection_Homo sapiens_hsa053300.49307700
85One carbon pool by folate_Homo sapiens_hsa006700.48451523
86TNF signaling pathway_Homo sapiens_hsa046680.48415868
87Antigen processing and presentation_Homo sapiens_hsa046120.46686599
88Toxoplasmosis_Homo sapiens_hsa051450.46412623
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44723382
90Metabolic pathways_Homo sapiens_hsa011000.39720013
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.38481692
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38422075
93Legionellosis_Homo sapiens_hsa051340.38391878
94Fructose and mannose metabolism_Homo sapiens_hsa000510.38004545
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.36396939
96Galactose metabolism_Homo sapiens_hsa000520.35965762
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.35889076
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31587948
99Autoimmune thyroid disease_Homo sapiens_hsa053200.31348088
100Bladder cancer_Homo sapiens_hsa052190.30457160
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.27482650
102Graft-versus-host disease_Homo sapiens_hsa053320.27097273
103Insulin resistance_Homo sapiens_hsa049310.25753259
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.25500733
105Linoleic acid metabolism_Homo sapiens_hsa005910.23334295
106Lysosome_Homo sapiens_hsa041420.17741865
107Glucagon signaling pathway_Homo sapiens_hsa049220.10630980
108Other glycan degradation_Homo sapiens_hsa005110.07281389
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06597457
110African trypanosomiasis_Homo sapiens_hsa051430.02281930
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01496313
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1884686
113Hepatitis C_Homo sapiens_hsa05160-0.1866582
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1547797
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1543844
116Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1505377
117Mineral absorption_Homo sapiens_hsa04978-0.1328546
118Ether lipid metabolism_Homo sapiens_hsa00565-0.1307901
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1295780
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1121667
121Malaria_Homo sapiens_hsa05144-0.1001892
122Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0878135
123Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0742157
124Insulin signaling pathway_Homo sapiens_hsa04910-0.0664065
125Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0624476
126Pertussis_Homo sapiens_hsa05133-0.0440375
127AMPK signaling pathway_Homo sapiens_hsa04152-0.0427668
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0122497

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