Rank | Gene Set | Z-score |
---|---|---|
1 | L-phenylalanine catabolic process (GO:0006559) | 6.85303716 |
2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.85303716 |
3 | L-phenylalanine metabolic process (GO:0006558) | 6.56049507 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.56049507 |
5 | * triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.43100526 |
6 | aromatic amino acid family catabolic process (GO:0009074) | 6.10269326 |
7 | alpha-linolenic acid metabolic process (GO:0036109) | 5.93904530 |
8 | tryptophan catabolic process (GO:0006569) | 5.52758200 |
9 | indole-containing compound catabolic process (GO:0042436) | 5.52758200 |
10 | indolalkylamine catabolic process (GO:0046218) | 5.52758200 |
11 | bile acid biosynthetic process (GO:0006699) | 5.50648935 |
12 | kynurenine metabolic process (GO:0070189) | 5.42510970 |
13 | * high-density lipoprotein particle remodeling (GO:0034375) | 5.37653727 |
14 | sulfur amino acid catabolic process (GO:0000098) | 5.29878427 |
15 | tryptophan metabolic process (GO:0006568) | 5.20106646 |
16 | urea metabolic process (GO:0019627) | 5.18826146 |
17 | urea cycle (GO:0000050) | 5.18826146 |
18 | negative regulation of fibrinolysis (GO:0051918) | 5.11914567 |
19 | glyoxylate metabolic process (GO:0046487) | 5.10839281 |
20 | complement activation, alternative pathway (GO:0006957) | 5.09508128 |
21 | * reverse cholesterol transport (GO:0043691) | 5.08150293 |
22 | protein carboxylation (GO:0018214) | 5.06230576 |
23 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.06230576 |
24 | regulation of cholesterol storage (GO:0010885) | 4.97103137 |
25 | cysteine metabolic process (GO:0006534) | 4.94063160 |
26 | regulation of protein activation cascade (GO:2000257) | 4.91899031 |
27 | regulation of fibrinolysis (GO:0051917) | 4.89016591 |
28 | * regulation of cholesterol esterification (GO:0010872) | 4.88762943 |
29 | * protein-lipid complex remodeling (GO:0034368) | 4.88318514 |
30 | * macromolecular complex remodeling (GO:0034367) | 4.88318514 |
31 | * plasma lipoprotein particle remodeling (GO:0034369) | 4.88318514 |
32 | regulation of triglyceride catabolic process (GO:0010896) | 4.77667904 |
33 | nitrogen cycle metabolic process (GO:0071941) | 4.76036726 |
34 | serine family amino acid catabolic process (GO:0009071) | 4.74556855 |
35 | glycosphingolipid catabolic process (GO:0046479) | 4.73182722 |
36 | bile acid metabolic process (GO:0008206) | 4.72753926 |
37 | oligosaccharide catabolic process (GO:0009313) | 4.72225994 |
38 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.68139695 |
39 | regulation of complement activation (GO:0030449) | 4.60895770 |
40 | * phospholipid efflux (GO:0033700) | 4.60846710 |
41 | regulation of apoptotic cell clearance (GO:2000425) | 4.54065898 |
42 | amino-acid betaine metabolic process (GO:0006577) | 4.50083536 |
43 | homocysteine metabolic process (GO:0050667) | 4.49163978 |
44 | * low-density lipoprotein particle remodeling (GO:0034374) | 4.43594478 |
45 | aromatic amino acid family metabolic process (GO:0009072) | 4.39237768 |
46 | alpha-amino acid catabolic process (GO:1901606) | 4.35981045 |
47 | tyrosine metabolic process (GO:0006570) | 4.31770058 |
48 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 4.30439595 |
49 | cellular ketone body metabolic process (GO:0046950) | 4.29199248 |
50 | lysine metabolic process (GO:0006553) | 4.26192168 |
51 | lysine catabolic process (GO:0006554) | 4.26192168 |
52 | * negative regulation of cholesterol transport (GO:0032375) | 4.25686379 |
53 | * negative regulation of sterol transport (GO:0032372) | 4.25686379 |
54 | * plasma lipoprotein particle clearance (GO:0034381) | 4.23890098 |
55 | acylglycerol homeostasis (GO:0055090) | 4.23471924 |
56 | triglyceride homeostasis (GO:0070328) | 4.23471924 |
57 | glycolipid catabolic process (GO:0019377) | 4.22129506 |
58 | cellular modified amino acid catabolic process (GO:0042219) | 4.19684541 |
59 | glutamate metabolic process (GO:0006536) | 4.16143773 |
60 | ethanol oxidation (GO:0006069) | 4.14310898 |
61 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.11917085 |
62 | * cholesterol efflux (GO:0033344) | 4.11244997 |
63 | cellular response to thyroid hormone stimulus (GO:0097067) | 4.10319280 |
64 | cellular amino acid catabolic process (GO:0009063) | 4.06338702 |
65 | dicarboxylic acid biosynthetic process (GO:0043650) | 4.03066693 |
66 | * plasma lipoprotein particle assembly (GO:0034377) | 4.00554246 |
67 | coenzyme catabolic process (GO:0009109) | 3.95640604 |
68 | amine catabolic process (GO:0009310) | 3.94267395 |
69 | cellular biogenic amine catabolic process (GO:0042402) | 3.94267395 |
70 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.93822268 |
71 | cellular glucuronidation (GO:0052695) | 3.93143320 |
72 | bile acid and bile salt transport (GO:0015721) | 3.92815792 |
73 | low-density lipoprotein particle clearance (GO:0034383) | 3.92195811 |
74 | phospholipid homeostasis (GO:0055091) | 3.89513909 |
75 | glycine metabolic process (GO:0006544) | 3.87610669 |
76 | imidazole-containing compound metabolic process (GO:0052803) | 3.87357210 |
77 | indolalkylamine metabolic process (GO:0006586) | 3.84467150 |
78 | complement activation (GO:0006956) | 3.84171933 |
79 | * plasma lipoprotein particle organization (GO:0071827) | 3.84170546 |
80 | complement activation, classical pathway (GO:0006958) | 3.79454259 |
81 | amino sugar catabolic process (GO:0046348) | 3.77448307 |
82 | serine family amino acid metabolic process (GO:0009069) | 3.75802675 |
83 | ketone body metabolic process (GO:1902224) | 3.75237220 |
84 | negative regulation of lipase activity (GO:0060192) | 3.75083592 |
85 | arginine metabolic process (GO:0006525) | 3.74221100 |
86 | short-chain fatty acid metabolic process (GO:0046459) | 3.73791929 |
87 | protein activation cascade (GO:0072376) | 3.72350739 |
88 | regulation of cholesterol homeostasis (GO:2000188) | 3.70859567 |
89 | positive regulation of lipid catabolic process (GO:0050996) | 3.70280044 |
90 | serine family amino acid biosynthetic process (GO:0009070) | 3.68682852 |
91 | ceramide catabolic process (GO:0046514) | 3.68586302 |
92 | benzene-containing compound metabolic process (GO:0042537) | 3.68450549 |
93 | fibrinolysis (GO:0042730) | 3.68031691 |
94 | response to thyroid hormone (GO:0097066) | 3.64507183 |
95 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.61492575 |
96 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.61492575 |
97 | * protein-lipid complex subunit organization (GO:0071825) | 3.61055771 |
98 | organic acid catabolic process (GO:0016054) | 3.58314941 |
99 | carboxylic acid catabolic process (GO:0046395) | 3.58314941 |
100 | * protein-lipid complex assembly (GO:0065005) | 3.57835971 |
101 | regulation of macrophage chemotaxis (GO:0010758) | 3.57550551 |
102 | linoleic acid metabolic process (GO:0043651) | 3.55868370 |
103 | regulation of mononuclear cell migration (GO:0071675) | 3.54885118 |
104 | drug catabolic process (GO:0042737) | 3.54561754 |
105 | apoptotic cell clearance (GO:0043277) | 3.54425543 |
106 | cofactor catabolic process (GO:0051187) | 3.53688577 |
107 | glucuronate metabolic process (GO:0019585) | 3.46545730 |
108 | uronic acid metabolic process (GO:0006063) | 3.46545730 |
109 | * cholesterol homeostasis (GO:0042632) | 3.46395501 |
110 | blood coagulation, intrinsic pathway (GO:0007597) | 3.45307417 |
111 | regulation of bile acid biosynthetic process (GO:0070857) | 3.45035242 |
112 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.44571731 |
113 | positive regulation of triglyceride metabolic process (GO:0090208) | 3.43707060 |
114 | carnitine metabolic process (GO:0009437) | 3.43203926 |
115 | detection of molecule of bacterial origin (GO:0032490) | 3.42844948 |
116 | * sterol homeostasis (GO:0055092) | 3.40143653 |
117 | regulation of lipoprotein particle clearance (GO:0010984) | 3.32676337 |
118 | N-acetylneuraminate metabolic process (GO:0006054) | 3.27560656 |
119 | regulation of fatty acid biosynthetic process (GO:0042304) | 3.25159405 |
120 | * positive regulation of steroid metabolic process (GO:0045940) | 3.25126375 |
121 | * positive regulation of cholesterol efflux (GO:0010875) | 3.20354369 |
122 | * negative regulation of lipid transport (GO:0032369) | 3.19356337 |
123 | chondroitin sulfate catabolic process (GO:0030207) | 3.17315517 |
124 | * regulation of sterol transport (GO:0032371) | 3.14370800 |
125 | * regulation of cholesterol transport (GO:0032374) | 3.14370800 |
126 | * lipoprotein metabolic process (GO:0042157) | 3.13168213 |
127 | positive regulation of hemostasis (GO:1900048) | 3.10402100 |
128 | positive regulation of blood coagulation (GO:0030194) | 3.10402100 |
129 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.07305146 |
130 | positive regulation of coagulation (GO:0050820) | 3.05576111 |
131 | * sterol transport (GO:0015918) | 3.00873838 |
132 | * cholesterol transport (GO:0030301) | 3.00873838 |
133 | barbed-end actin filament capping (GO:0051016) | 3.00778999 |
134 | acute-phase response (GO:0006953) | 2.99346698 |
135 | positive regulation of phagocytosis (GO:0050766) | 2.97938029 |
136 | omega-hydroxylase P450 pathway (GO:0097267) | 2.95026308 |
137 | cellular response to cadmium ion (GO:0071276) | 2.94166072 |
138 | epoxygenase P450 pathway (GO:0019373) | 2.89180699 |
139 | sphingolipid catabolic process (GO:0030149) | 2.84773672 |
140 | regulation of superoxide anion generation (GO:0032928) | 2.82608444 |
141 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 2.82307781 |
142 | membrane lipid catabolic process (GO:0046466) | 2.82020094 |
143 | regulation of plasminogen activation (GO:0010755) | 2.77443493 |
144 | positive regulation of lipid storage (GO:0010884) | 2.76717784 |
145 | * positive regulation of cholesterol transport (GO:0032376) | 2.74044281 |
146 | * positive regulation of sterol transport (GO:0032373) | 2.74044281 |
147 | vitamin D metabolic process (GO:0042359) | 2.68851710 |
148 | positive regulation of extracellular matrix organization (GO:1903055) | 2.67437256 |
149 | * negative regulation of blood coagulation (GO:0030195) | 2.64935964 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.61237766 |
2 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.50127714 |
3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.01695141 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.98292136 |
5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.12369930 |
6 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.80220976 |
7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.20390010 |
8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.65384513 |
9 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.28681928 |
10 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.45556080 |
11 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.23540412 |
12 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.03220066 |
13 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 10.8640075 |
14 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.91152555 |
15 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.86857794 |
16 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.77195728 |
17 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.69168568 |
18 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.63340615 |
19 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.53836089 |
20 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.53038337 |
21 | KDM2B_26808549_Chip-Seq_K562_Human | 1.52378847 |
22 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.46104973 |
23 | GATA1_22025678_ChIP-Seq_K562_Human | 1.41782451 |
24 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.41448493 |
25 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.41362279 |
26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.36745491 |
27 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.34781550 |
28 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.32308985 |
29 | * BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.30209918 |
30 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.29605759 |
31 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.27789831 |
32 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27562401 |
33 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.26129496 |
34 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.24884834 |
35 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.24287908 |
36 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.21417443 |
37 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.20974137 |
38 | SPI1_23127762_ChIP-Seq_K562_Human | 1.17679414 |
39 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.17475049 |
40 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.17323933 |
41 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.16828672 |
42 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.16778923 |
43 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.16467298 |
44 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.10182736 |
45 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.09718037 |
46 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.09678217 |
47 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.09259593 |
48 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.08377324 |
49 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08066994 |
50 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.07040254 |
51 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.05882840 |
52 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.04667122 |
53 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.04354694 |
54 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.04064884 |
55 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.03177747 |
56 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.02124952 |
57 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.01822710 |
58 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.00377517 |
59 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.00118577 |
60 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.00105709 |
61 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.99687571 |
62 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.99606511 |
63 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.98894339 |
64 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.96322637 |
65 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 0.95467146 |
66 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.95100063 |
67 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.92767934 |
68 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.91754668 |
69 | P68_20966046_ChIP-Seq_HELA_Human | 0.91326994 |
70 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.90150512 |
71 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.89726778 |
72 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.89726778 |
73 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.89497843 |
74 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.89365249 |
75 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.89208088 |
76 | MITF_21258399_ChIP-Seq_MELANOMA_Human | 0.88588459 |
77 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.88428129 |
78 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.88001974 |
79 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.86471778 |
80 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.86437156 |
81 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86089857 |
82 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85023920 |
83 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.84767970 |
84 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.83334643 |
85 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.83304355 |
86 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.83092760 |
87 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.78217517 |
88 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.77670657 |
89 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.76609408 |
90 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.74686321 |
91 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.74686321 |
92 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.72763119 |
93 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.71973335 |
94 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.69740501 |
95 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.69033494 |
96 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.68649359 |
97 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.68490875 |
98 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.68241547 |
99 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.68189660 |
100 | GATA1_19941826_ChIP-Seq_K562_Human | 0.67896704 |
101 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.65947626 |
102 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.65575837 |
103 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.63807817 |
104 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.63691370 |
105 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.63563805 |
106 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.63442488 |
107 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.63078945 |
108 | * SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.62450185 |
109 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.61851884 |
110 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.60314533 |
111 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.60085499 |
112 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.59643969 |
113 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.59178765 |
114 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.58317214 |
115 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.57947507 |
116 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.57568906 |
117 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.57440551 |
118 | GATA2_19941826_ChIP-Seq_K562_Human | 0.57067530 |
119 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.56591492 |
120 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.56368379 |
121 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.56279553 |
122 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.55941637 |
123 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.54266465 |
124 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.52981544 |
125 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.52261723 |
126 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.51700808 |
127 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.51139048 |
128 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.49896929 |
129 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.49402558 |
130 | CBP_21632823_ChIP-Seq_H3396_Human | 0.48571721 |
131 | AR_20517297_ChIP-Seq_VCAP_Human | 0.46800170 |
132 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.46680288 |
133 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.46444325 |
134 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.45891706 |
135 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.45728047 |
136 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.45279957 |
137 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.44059453 |
138 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.43655927 |
139 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.43393096 |
140 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.42987921 |
141 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.42320506 |
142 | * CTCF_27219007_Chip-Seq_Bcells_Human | 0.41703569 |
143 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.41279250 |
144 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.40877950 |
145 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.40753149 |
146 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.40710112 |
147 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.40215550 |
148 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.39524463 |
149 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.39003020 |
150 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.38966601 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 7.92925908 |
2 | MP0005360_urolithiasis | 6.90342950 |
3 | MP0005085_abnormal_gallbladder_physiolo | 5.94634257 |
4 | MP0005365_abnormal_bile_salt | 5.91433483 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.91053347 |
6 | MP0003806_abnormal_nucleotide_metabolis | 3.84065962 |
7 | * MP0010329_abnormal_lipoprotein_level | 3.65347539 |
8 | * MP0009840_abnormal_foam_cell | 3.57868929 |
9 | MP0003252_abnormal_bile_duct | 3.55937769 |
10 | MP0005083_abnormal_biliary_tract | 2.91144691 |
11 | MP0003191_abnormal_cellular_cholesterol | 2.83538111 |
12 | * MP0005332_abnormal_amino_acid | 2.76603116 |
13 | MP0003195_calcinosis | 2.59120104 |
14 | MP0003303_peritoneal_inflammation | 2.56091142 |
15 | MP0001666_abnormal_nutrient_absorption | 2.42240921 |
16 | MP0002254_reproductive_system_inflammat | 2.30089473 |
17 | * MP0002118_abnormal_lipid_homeostasis | 2.19372852 |
18 | * MP0000609_abnormal_liver_physiology | 2.16215747 |
19 | MP0003011_delayed_dark_adaptation | 2.02775194 |
20 | MP0000920_abnormal_myelination | 2.02315696 |
21 | * MP0004019_abnormal_vitamin_homeostasis | 1.96190687 |
22 | MP0005257_abnormal_intraocular_pressure | 1.86416003 |
23 | * MP0005319_abnormal_enzyme/_coenzyme | 1.74602675 |
24 | MP0002138_abnormal_hepatobiliary_system | 1.65833889 |
25 | MP0009278_abnormal_bone_marrow | 1.64374919 |
26 | * MP0005584_abnormal_enzyme/coenzyme_acti | 1.64004586 |
27 | MP0003868_abnormal_feces_composition | 1.57388272 |
28 | * MP0002998_abnormal_bone_remodeling | 1.55931420 |
29 | * MP0000343_altered_response_to | 1.55857790 |
30 | MP0003879_abnormal_hair_cell | 1.53576493 |
31 | MP0001764_abnormal_homeostasis | 1.51696814 |
32 | * MP0003690_abnormal_glial_cell | 1.51203253 |
33 | MP0009785_altered_susceptibility_to | 1.49146936 |
34 | * MP0000604_amyloidosis | 1.46157046 |
35 | * MP0003634_abnormal_glial_cell | 1.44025391 |
36 | MP0009697_abnormal_copulation | 1.43614938 |
37 | MP0003453_abnormal_keratinocyte_physiol | 1.40921255 |
38 | MP0003705_abnormal_hypodermis_morpholog | 1.40306302 |
39 | * MP0002148_abnormal_hypersensitivity_rea | 1.37238619 |
40 | MP0005058_abnormal_lysosome_morphology | 1.34600135 |
41 | * MP0003632_abnormal_nervous_system | 1.33153264 |
42 | MP0003656_abnormal_erythrocyte_physiolo | 1.31840142 |
43 | MP0004510_myositis | 1.29638424 |
44 | MP0005397_hematopoietic_system_phenotyp | 1.26277677 |
45 | MP0001545_abnormal_hematopoietic_system | 1.26277677 |
46 | MP0005647_abnormal_sex_gland | 1.25447915 |
47 | MP0005670_abnormal_white_adipose | 1.23454054 |
48 | MP0005451_abnormal_body_composition | 1.23140268 |
49 | * MP0009643_abnormal_urine_homeostasis | 1.18289105 |
50 | * MP0005025_abnormal_response_to | 1.16532682 |
51 | * MP0009764_decreased_sensitivity_to | 1.14849448 |
52 | * MP0001533_abnormal_skeleton_physiology | 1.12749529 |
53 | MP0000598_abnormal_liver_morphology | 1.10302275 |
54 | MP0001915_intracranial_hemorrhage | 1.10179810 |
55 | MP0008260_abnormal_autophagy | 1.09976756 |
56 | * MP0003186_abnormal_redox_activity | 1.07885628 |
57 | MP0004130_abnormal_muscle_cell | 1.07675667 |
58 | MP0005171_absent_coat_pigmentation | 1.03224022 |
59 | * MP0009763_increased_sensitivity_to | 1.00387306 |
60 | MP0003136_yellow_coat_color | 0.98319890 |
61 | MP0003183_abnormal_peptide_metabolism | 0.97622238 |
62 | MP0000858_altered_metastatic_potential | 0.96878912 |
63 | * MP0008469_abnormal_protein_level | 0.96347616 |
64 | * MP0003075_altered_response_to | 0.94894857 |
65 | * MP0009642_abnormal_blood_homeostasis | 0.90009605 |
66 | MP0010368_abnormal_lymphatic_system | 0.86994240 |
67 | MP0000371_diluted_coat_color | 0.86500013 |
68 | MP0001849_ear_inflammation | 0.86190358 |
69 | MP0005636_abnormal_mineral_homeostasis | 0.85839690 |
70 | * MP0005000_abnormal_immune_tolerance | 0.85036699 |
71 | MP0003448_altered_tumor_morphology | 0.82320417 |
72 | * MP0005387_immune_system_phenotype | 0.81967433 |
73 | * MP0001790_abnormal_immune_system | 0.81967433 |
74 | * MP0003329_amyloid_beta_deposits | 0.81056233 |
75 | MP0002089_abnormal_postnatal_growth/wei | 0.80935270 |
76 | MP0005535_abnormal_body_temperature | 0.79362243 |
77 | MP0005464_abnormal_platelet_physiology | 0.79071069 |
78 | MP0005167_abnormal_blood-brain_barrier | 0.78535514 |
79 | MP0005671_abnormal_response_to | 0.77422358 |
80 | * MP0002078_abnormal_glucose_homeostasis | 0.74579612 |
81 | * MP0002452_abnormal_antigen_presenting | 0.73405809 |
82 | MP0005023_abnormal_wound_healing | 0.71706444 |
83 | MP0003828_pulmonary_edema | 0.71704395 |
84 | * MP0001853_heart_inflammation | 0.71638079 |
85 | * MP0002971_abnormal_brown_adipose | 0.70849850 |
86 | * MP0005376_homeostasis/metabolism_phenot | 0.70672974 |
87 | MP0002090_abnormal_vision | 0.70330386 |
88 | MP0003091_abnormal_cell_migration | 0.70184246 |
89 | * MP0005334_abnormal_fat_pad | 0.69660269 |
90 | * MP0005595_abnormal_vascular_smooth | 0.68878302 |
91 | MP0008874_decreased_physiological_sensi | 0.67661484 |
92 | MP0009765_abnormal_xenobiotic_induced | 0.66496943 |
93 | MP0002876_abnormal_thyroid_physiology | 0.64069237 |
94 | MP0002877_abnormal_melanocyte_morpholog | 0.63677848 |
95 | MP0002896_abnormal_bone_mineralization | 0.63661923 |
96 | MP0001756_abnormal_urination | 0.62919820 |
97 | MP0001835_abnormal_antigen_presentation | 0.62884896 |
98 | MP0003436_decreased_susceptibility_to | 0.61786081 |
99 | MP0002822_catalepsy | 0.60973265 |
100 | * MP0005164_abnormal_response_to | 0.60822415 |
101 | MP0003724_increased_susceptibility_to | 0.60812208 |
102 | MP0008004_abnormal_stomach_pH | 0.59662660 |
103 | MP0009384_cardiac_valve_regurgitation | 0.59658738 |
104 | MP0002933_joint_inflammation | 0.59467866 |
105 | MP0006036_abnormal_mitochondrial_physio | 0.58733218 |
106 | * MP0004947_skin_inflammation | 0.58641378 |
107 | * MP0005166_decreased_susceptibility_to | 0.56827976 |
108 | MP0005666_abnormal_adipose_tissue | 0.56218602 |
109 | * MP0000639_abnormal_adrenal_gland | 0.54989126 |
110 | MP0005084_abnormal_gallbladder_morpholo | 0.53171668 |
111 | * MP0003638_abnormal_response/metabolism_ | 0.52659665 |
112 | MP0006082_CNS_inflammation | 0.52420436 |
113 | MP0005266_abnormal_metabolism | 0.52096523 |
114 | MP0001661_extended_life_span | 0.50287491 |
115 | * MP0002136_abnormal_kidney_physiology | 0.49698532 |
116 | MP0003172_abnormal_lysosome_physiology | 0.49381713 |
117 | * MP0005448_abnormal_energy_balance | 0.49209113 |
118 | MP0005408_hypopigmentation | 0.47214418 |
119 | MP0008872_abnormal_physiological_respon | 0.45579725 |
120 | MP0009053_abnormal_anal_canal | 0.44805386 |
121 | MP0008873_increased_physiological_sensi | 0.43462745 |
122 | * MP0003953_abnormal_hormone_level | 0.43194300 |
123 | * MP0003633_abnormal_nervous_system | 0.42845786 |
124 | * MP0000249_abnormal_blood_vessel | 0.42784787 |
125 | MP0005395_other_phenotype | 0.41620206 |
126 | MP0002796_impaired_skin_barrier | 0.41065503 |
127 | MP0001881_abnormal_mammary_gland | 0.41060330 |
128 | MP0003300_gastrointestinal_ulcer | 0.40721145 |
129 | MP0002295_abnormal_pulmonary_circulatio | 0.40596194 |
130 | * MP0002419_abnormal_innate_immunity | 0.40592408 |
131 | MP0002168_other_aberrant_phenotype | 0.39694490 |
132 | MP0004858_abnormal_nervous_system | 0.39656093 |
133 | MP0004782_abnormal_surfactant_physiolog | 0.39295210 |
134 | * MP0009115_abnormal_fat_cell | 0.39016737 |
135 | MP0000579_abnormal_nail_morphology | 0.38823557 |
136 | MP0002132_abnormal_respiratory_system | 0.36437737 |
137 | MP0005248_abnormal_Harderian_gland | 0.36237688 |
138 | * MP0001845_abnormal_inflammatory_respons | 0.36016718 |
139 | MP0005220_abnormal_exocrine_pancreas | 0.34659016 |
140 | MP0004885_abnormal_endolymph | 0.33482777 |
141 | * MP0003631_nervous_system_phenotype | 0.32938710 |
142 | * MP0000230_abnormal_systemic_arterial | 0.30882213 |
143 | MP0006035_abnormal_mitochondrial_morpho | 0.30827404 |
144 | MP0002928_abnormal_bile_duct | 0.29840773 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of liposaccharide metabolism (HP:0010968) | 7.32968001 |
2 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 7.32968001 |
3 | Abnormality of glycolipid metabolism (HP:0010969) | 7.32968001 |
4 | Deep venous thrombosis (HP:0002625) | 6.99031167 |
5 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 6.72592094 |
6 | Intrahepatic cholestasis (HP:0001406) | 6.55715701 |
7 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.12303858 |
8 | Prolonged partial thromboplastin time (HP:0003645) | 6.05817808 |
9 | * Xanthomatosis (HP:0000991) | 5.96134681 |
10 | Complement deficiency (HP:0004431) | 5.80976989 |
11 | Hyperlipoproteinemia (HP:0010980) | 5.74617596 |
12 | Hypobetalipoproteinemia (HP:0003563) | 5.71947511 |
13 | Increased cerebral lipofuscin (HP:0011813) | 4.94828716 |
14 | Hypolipoproteinemia (HP:0010981) | 4.77026119 |
15 | Joint hemorrhage (HP:0005261) | 4.74425538 |
16 | Hypoalphalipoproteinemia (HP:0003233) | 4.65690104 |
17 | Hyperammonemia (HP:0001987) | 4.49544584 |
18 | Vacuolated lymphocytes (HP:0001922) | 4.48796644 |
19 | Hyperglycinemia (HP:0002154) | 4.36584589 |
20 | Abnormality of complement system (HP:0005339) | 4.35435354 |
21 | Dysostosis multiplex (HP:0000943) | 4.33949370 |
22 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.30432098 |
23 | Epidermoid cyst (HP:0200040) | 4.29606560 |
24 | Systemic lupus erythematosus (HP:0002725) | 4.19251218 |
25 | Abnormality of methionine metabolism (HP:0010901) | 4.18047665 |
26 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.13990481 |
27 | Hyperglycinuria (HP:0003108) | 4.13709331 |
28 | Abnormality of the common coagulation pathway (HP:0010990) | 4.11038978 |
29 | Ketosis (HP:0001946) | 4.10959961 |
30 | Abnormality of glycine metabolism (HP:0010895) | 4.04891231 |
31 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.04891231 |
32 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.98450607 |
33 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.90910095 |
34 | Retinal atrophy (HP:0001105) | 3.80143822 |
35 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.76438039 |
36 | Hypoglycemic coma (HP:0001325) | 3.64832077 |
37 | Fat malabsorption (HP:0002630) | 3.63696563 |
38 | Glomerulonephritis (HP:0000099) | 3.62385975 |
39 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.54063933 |
40 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.54063933 |
41 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 3.54063933 |
42 | Mucopolysacchariduria (HP:0008155) | 3.52238608 |
43 | Urinary glycosaminoglycan excretion (HP:0003541) | 3.52238608 |
44 | Loss of speech (HP:0002371) | 3.45452085 |
45 | Purpura (HP:0000979) | 3.43619525 |
46 | Myocardial infarction (HP:0001658) | 3.37778274 |
47 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.35020216 |
48 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.32132770 |
49 | Disinhibition (HP:0000734) | 3.27759841 |
50 | Delayed CNS myelination (HP:0002188) | 3.26846149 |
51 | Abnormality of the intrinsic pathway (HP:0010989) | 3.26184590 |
52 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.25792142 |
53 | * Hypercholesterolemia (HP:0003124) | 3.24325381 |
54 | * Neurofibrillary tangles (HP:0002185) | 3.23140129 |
55 | Conjugated hyperbilirubinemia (HP:0002908) | 3.14039608 |
56 | Mutism (HP:0002300) | 3.10841063 |
57 | Hyperbilirubinemia (HP:0002904) | 3.06914753 |
58 | Ketoacidosis (HP:0001993) | 3.06092290 |
59 | Abnormality of macrophages (HP:0004311) | 3.02103839 |
60 | Eczematoid dermatitis (HP:0000976) | 2.98940693 |
61 | Amyloidosis (HP:0011034) | 2.92877968 |
62 | Abnormality of serum amino acid levels (HP:0003112) | 2.90469284 |
63 | Abnormality of the periventricular white matter (HP:0002518) | 2.81284581 |
64 | Steatorrhea (HP:0002570) | 2.75723510 |
65 | Skin nodule (HP:0200036) | 2.72507185 |
66 | Abnormality of nucleobase metabolism (HP:0010932) | 2.72144602 |
67 | Hepatocellular carcinoma (HP:0001402) | 2.60953700 |
68 | Vascular calcification (HP:0004934) | 2.59958418 |
69 | Spontaneous abortion (HP:0005268) | 2.54377301 |
70 | Mitral stenosis (HP:0001718) | 2.52899419 |
71 | Metabolic acidosis (HP:0001942) | 2.49705504 |
72 | Nuclear cataract (HP:0100018) | 2.49389277 |
73 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.49319530 |
74 | Dicarboxylic aciduria (HP:0003215) | 2.49319530 |
75 | Sensorimotor neuropathy (HP:0007141) | 2.47876848 |
76 | Neuronal loss in central nervous system (HP:0002529) | 2.44730328 |
77 | Hypoglycemic seizures (HP:0002173) | 2.42288410 |
78 | Abnormality of purine metabolism (HP:0004352) | 2.40706795 |
79 | * Cerebral inclusion bodies (HP:0100314) | 2.39028731 |
80 | Nephritis (HP:0000123) | 2.37896090 |
81 | Pathologic fracture (HP:0002756) | 2.36789234 |
82 | Lethargy (HP:0001254) | 2.36246767 |
83 | Peripheral demyelination (HP:0011096) | 2.35980163 |
84 | Apathy (HP:0000741) | 2.34773155 |
85 | Irritability (HP:0000737) | 2.34324303 |
86 | Esophageal varix (HP:0002040) | 2.32498125 |
87 | Cardiovascular calcification (HP:0011915) | 2.28466164 |
88 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.28439829 |
89 | Abnormal gallbladder morphology (HP:0012437) | 2.26694017 |
90 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.26631899 |
91 | Abnormal gallbladder physiology (HP:0012438) | 2.26461148 |
92 | Cholecystitis (HP:0001082) | 2.26461148 |
93 | Hypochromic microcytic anemia (HP:0004840) | 2.23868769 |
94 | Diminished motivation (HP:0000745) | 2.23694919 |
95 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.23303528 |
96 | Spastic diplegia (HP:0001264) | 2.23083759 |
97 | Cholelithiasis (HP:0001081) | 2.22963565 |
98 | Neonatal onset (HP:0003623) | 2.20888361 |
99 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.19982378 |
100 | Hydroxyprolinuria (HP:0003080) | 2.16237016 |
101 | Abnormality of proline metabolism (HP:0010907) | 2.16237016 |
102 | Recurrent abscess formation (HP:0002722) | 2.16200640 |
103 | Status epilepticus (HP:0002133) | 2.15616354 |
104 | * Dementia (HP:0000726) | 2.14996405 |
105 | Acanthocytosis (HP:0001927) | 2.13621271 |
106 | Gingival bleeding (HP:0000225) | 2.11373945 |
107 | Back pain (HP:0003418) | 2.08875817 |
108 | Recurrent bacterial skin infections (HP:0005406) | 2.08172552 |
109 | Malnutrition (HP:0004395) | 2.06513210 |
110 | Gout (HP:0001997) | 2.06315907 |
111 | Vertebral compression fractures (HP:0002953) | 2.06184842 |
112 | Pancreatitis (HP:0001733) | 2.06147543 |
113 | Increased CSF protein (HP:0002922) | 2.03858425 |
114 | Supranuclear gaze palsy (HP:0000605) | 2.01810969 |
115 | Brushfield spots (HP:0001088) | 2.01683809 |
116 | Menorrhagia (HP:0000132) | 2.00263408 |
117 | Increased serum ferritin (HP:0003281) | 1.99002974 |
118 | Orchitis (HP:0100796) | 1.98329979 |
119 | Thrombophlebitis (HP:0004418) | 1.98283044 |
120 | J-shaped sella turcica (HP:0002680) | 1.95743531 |
121 | Autoimmune thrombocytopenia (HP:0001973) | 1.94222800 |
122 | Progressive neurologic deterioration (HP:0002344) | 1.93327192 |
123 | Vomiting (HP:0002013) | 1.93309667 |
124 | Hepatosplenomegaly (HP:0001433) | 1.93092143 |
125 | Axonal loss (HP:0003447) | 1.92198171 |
126 | Cerebral edema (HP:0002181) | 1.92078826 |
127 | Hemorrhage of the eye (HP:0011885) | 1.90030460 |
128 | Peripheral hypomyelination (HP:0007182) | 1.86795878 |
129 | Bone pain (HP:0002653) | 1.86525930 |
130 | Abnormality of iron homeostasis (HP:0011031) | 1.86498626 |
131 | Abnormality of the Achilles tendon (HP:0005109) | 1.86194230 |
132 | Generalized aminoaciduria (HP:0002909) | 1.85747230 |
133 | Enlarged kidneys (HP:0000105) | 1.85095182 |
134 | Global brain atrophy (HP:0002283) | 1.84119262 |
135 | Asymmetric septal hypertrophy (HP:0001670) | 1.83931852 |
136 | Optic neuritis (HP:0100653) | 1.82434053 |
137 | Retrobulbar optic neuritis (HP:0100654) | 1.82434053 |
138 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.82211603 |
139 | Abnormality of the gallbladder (HP:0005264) | 1.82191755 |
140 | Stroke (HP:0001297) | 1.79931222 |
141 | Opisthotonus (HP:0002179) | 1.79795650 |
142 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.78721116 |
143 | Agnosia (HP:0010524) | 1.78359398 |
144 | Metaphyseal irregularity (HP:0003025) | 1.77530535 |
145 | Pseudobulbar signs (HP:0002200) | 1.76851187 |
146 | Multiple enchondromatosis (HP:0005701) | 1.76806233 |
147 | Thoracic kyphosis (HP:0002942) | 1.75766447 |
148 | Upper motor neuron abnormality (HP:0002127) | 1.75429867 |
149 | Personality changes (HP:0000751) | 1.75116820 |
150 | Rickets (HP:0002748) | 1.75084915 |
151 | Cardiomegaly (HP:0001640) | 1.73547767 |
152 | Hypophosphatemic rickets (HP:0004912) | 1.72192813 |
153 | Protuberant abdomen (HP:0001538) | 1.71649599 |
154 | Cerebral aneurysm (HP:0004944) | 1.69980187 |
155 | Abnormality of the lumbar spine (HP:0100712) | 1.69083808 |
156 | Inappropriate behavior (HP:0000719) | 1.68731342 |
157 | Gingivitis (HP:0000230) | 1.68460944 |
158 | Abnormality of vitamin metabolism (HP:0100508) | 1.68349800 |
159 | Elevated hepatic transaminases (HP:0002910) | 1.67817014 |
160 | Paraparesis (HP:0002385) | 1.66592161 |
161 | Polycythemia (HP:0001901) | 1.66073793 |
162 | Pulmonary embolism (HP:0002204) | 1.65528932 |
163 | Prolonged neonatal jaundice (HP:0006579) | 1.65436985 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 5.77893952 |
2 | SIK1 | 4.70721792 |
3 | ERN1 | 4.11994122 |
4 | FGFR4 | 3.44371609 |
5 | DDR2 | 3.20713978 |
6 | TRIB3 | 2.51466507 |
7 | EPHA4 | 2.48561286 |
8 | NME2 | 2.39765308 |
9 | PRPF4B | 2.16522555 |
10 | TAOK3 | 2.11655626 |
11 | TYRO3 | 2.10948488 |
12 | INSRR | 2.07267485 |
13 | LMTK2 | 2.06473875 |
14 | MST1R | 1.99038522 |
15 | DAPK2 | 1.94398343 |
16 | PDGFRA | 1.89889465 |
17 | TYK2 | 1.88894580 |
18 | MAP2K4 | 1.85799885 |
19 | PKN2 | 1.82338090 |
20 | ICK | 1.71775853 |
21 | TGFBR2 | 1.69939958 |
22 | ERBB4 | 1.64445371 |
23 | CAMK1D | 1.61408312 |
24 | ACVR1B | 1.53186701 |
25 | PIK3CG | 1.47529783 |
26 | NTRK3 | 1.46006712 |
27 | PINK1 | 1.45162616 |
28 | IRAK3 | 1.44412835 |
29 | PTK6 | 1.44226871 |
30 | MAPK11 | 1.42420663 |
31 | GRK6 | 1.34178534 |
32 | JAK2 | 1.31510244 |
33 | MAPK12 | 1.28538836 |
34 | TBK1 | 1.25070471 |
35 | PDK2 | 1.24913521 |
36 | CDC42BPA | 1.21324640 |
37 | PHKG2 | 1.16350718 |
38 | PHKG1 | 1.16350718 |
39 | EPHB1 | 1.15376366 |
40 | JAK1 | 1.14854761 |
41 | RIPK1 | 1.12441615 |
42 | FES | 1.05729627 |
43 | MAP3K7 | 1.05454040 |
44 | ABL2 | 1.03968026 |
45 | MET | 1.02848844 |
46 | NEK9 | 1.01808093 |
47 | PRKAA2 | 1.00444131 |
48 | MAPK4 | 0.99282380 |
49 | BLK | 0.98613810 |
50 | FGFR2 | 0.96940590 |
51 | SGK3 | 0.96829026 |
52 | MAP3K14 | 0.95874770 |
53 | LATS2 | 0.95852603 |
54 | CAMKK2 | 0.95073565 |
55 | FLT3 | 0.94838610 |
56 | MAP3K13 | 0.93449536 |
57 | CAMK1G | 0.90635257 |
58 | KDR | 0.89732954 |
59 | ARAF | 0.83940743 |
60 | BMX | 0.82921568 |
61 | RIPK4 | 0.82424084 |
62 | PKN1 | 0.82080410 |
63 | ZAP70 | 0.81741275 |
64 | SGK2 | 0.80783154 |
65 | PRKACG | 0.80670958 |
66 | PRKCG | 0.79940055 |
67 | NTRK2 | 0.79203081 |
68 | CAMKK1 | 0.78781117 |
69 | PRKCZ | 0.78276334 |
70 | PIM2 | 0.77428138 |
71 | MAPK7 | 0.76474813 |
72 | PAK4 | 0.73697086 |
73 | RPS6KA2 | 0.69154527 |
74 | CDK6 | 0.68996282 |
75 | SGK223 | 0.68022398 |
76 | SGK494 | 0.68022398 |
77 | MAPK15 | 0.67097821 |
78 | ERBB2 | 0.66568416 |
79 | CSF1R | 0.65743294 |
80 | MARK2 | 0.65047782 |
81 | IGF1R | 0.64894497 |
82 | PDGFRB | 0.64875581 |
83 | CSK | 0.64000998 |
84 | MOS | 0.63807620 |
85 | TESK1 | 0.62768938 |
86 | CAMK2G | 0.60122058 |
87 | NTRK1 | 0.59567703 |
88 | RET | 0.59048580 |
89 | PDPK1 | 0.58577903 |
90 | JAK3 | 0.56620838 |
91 | FGFR3 | 0.56476062 |
92 | PRKG2 | 0.56439154 |
93 | KSR2 | 0.53257430 |
94 | SMG1 | 0.53209687 |
95 | LATS1 | 0.53057480 |
96 | IKBKE | 0.52752888 |
97 | TIE1 | 0.52130824 |
98 | ALK | 0.51832017 |
99 | PTK2 | 0.51312265 |
100 | STK38 | 0.51108535 |
101 | RPS6KL1 | 0.50992765 |
102 | RPS6KC1 | 0.50992765 |
103 | CAMK2B | 0.50795338 |
104 | CAMK4 | 0.49585355 |
105 | PRKAA1 | 0.48902012 |
106 | MAP2K1 | 0.48667135 |
107 | KIT | 0.48581645 |
108 | MAP2K3 | 0.48333379 |
109 | GSK3A | 0.48200547 |
110 | IKBKB | 0.46906823 |
111 | MAP2K6 | 0.46512208 |
112 | DYRK1B | 0.46470886 |
113 | MAP3K2 | 0.45894613 |
114 | SIK2 | 0.45442099 |
115 | EPHA3 | 0.44859151 |
116 | EGFR | 0.44775564 |
117 | PDK1 | 0.44566070 |
118 | GRK7 | 0.43963901 |
119 | PRKCQ | 0.43922843 |
120 | LYN | 0.43566276 |
121 | IRAK2 | 0.43174763 |
122 | ROCK2 | 0.42945692 |
123 | SRC | 0.42612868 |
124 | SGK1 | 0.42045252 |
125 | PAK6 | 0.41829322 |
126 | EEF2K | 0.41222143 |
127 | MAP3K3 | 0.40543191 |
128 | IRAK1 | 0.39353286 |
129 | MAP3K11 | 0.39327471 |
130 | PRKCA | 0.37923526 |
131 | FGR | 0.35552780 |
132 | MAP3K1 | 0.33593791 |
133 | TNK2 | 0.32512872 |
134 | MATK | 0.32414164 |
135 | MAP2K2 | 0.31103671 |
136 | FRK | 0.30315173 |
137 | PRKD1 | 0.28106423 |
138 | TAOK2 | 0.27550971 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.26788648 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 4.20053721 |
3 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.17725175 |
4 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.99265574 |
5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.96178384 |
6 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.90380310 |
7 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.82788626 |
8 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.67526232 |
9 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.48669491 |
10 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.45132612 |
11 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.38353610 |
12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.33701388 |
13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.21776983 |
14 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.21226033 |
15 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.08656188 |
16 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.08143447 |
17 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.06473500 |
18 | Peroxisome_Homo sapiens_hsa04146 | 2.05460208 |
19 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.02155205 |
20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.94870887 |
21 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.88340659 |
22 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.83206934 |
23 | Histidine metabolism_Homo sapiens_hsa00340 | 1.77760463 |
24 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.77180273 |
25 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.71154053 |
26 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.68622432 |
27 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.67230881 |
28 | Retinol metabolism_Homo sapiens_hsa00830 | 1.58398222 |
29 | Bile secretion_Homo sapiens_hsa04976 | 1.57108656 |
30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.56904389 |
31 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.56234821 |
32 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.43839420 |
33 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.42740358 |
34 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.38595979 |
35 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.37101360 |
36 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.35104174 |
37 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.30193578 |
38 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.29936724 |
39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.26393864 |
40 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.26017631 |
41 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.25555010 |
42 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.22958026 |
43 | ABC transporters_Homo sapiens_hsa02010 | 1.22830083 |
44 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.22449628 |
45 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.22279630 |
46 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.19924796 |
47 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.19339719 |
48 | Phagosome_Homo sapiens_hsa04145 | 1.19291485 |
49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.18413952 |
50 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.17200905 |
51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.16517856 |
52 | Carbon metabolism_Homo sapiens_hsa01200 | 1.10090846 |
53 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.09987983 |
54 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.04072207 |
55 | Leishmaniasis_Homo sapiens_hsa05140 | 1.00974034 |
56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.96161774 |
57 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.95930746 |
58 | Tuberculosis_Homo sapiens_hsa05152 | 0.94835740 |
59 | Sulfur relay system_Homo sapiens_hsa04122 | 0.94586658 |
60 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.92903221 |
61 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.92107268 |
62 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.91252736 |
63 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.85392783 |
64 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.84853091 |
65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.84514012 |
66 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.83321173 |
67 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.83238858 |
68 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.76604592 |
69 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.75513139 |
70 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.72141585 |
71 | Lysine degradation_Homo sapiens_hsa00310 | 0.71992617 |
72 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.71600160 |
73 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.66840651 |
74 | Asthma_Homo sapiens_hsa05310 | 0.62099022 |
75 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.60778088 |
76 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.60705051 |
77 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.60202478 |
78 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.57778188 |
79 | Amoebiasis_Homo sapiens_hsa05146 | 0.55392548 |
80 | Salmonella infection_Homo sapiens_hsa05132 | 0.54641399 |
81 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.53002271 |
82 | Prion diseases_Homo sapiens_hsa05020 | 0.51726893 |
83 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.50082852 |
84 | Allograft rejection_Homo sapiens_hsa05330 | 0.49307700 |
85 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.48451523 |
86 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.48415868 |
87 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.46686599 |
88 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.46412623 |
89 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.44723382 |
90 | Metabolic pathways_Homo sapiens_hsa01100 | 0.39720013 |
91 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.38481692 |
92 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.38422075 |
93 | Legionellosis_Homo sapiens_hsa05134 | 0.38391878 |
94 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.38004545 |
95 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.36396939 |
96 | Galactose metabolism_Homo sapiens_hsa00052 | 0.35965762 |
97 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.35889076 |
98 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.31587948 |
99 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.31348088 |
100 | Bladder cancer_Homo sapiens_hsa05219 | 0.30457160 |
101 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.27482650 |
102 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.27097273 |
103 | Insulin resistance_Homo sapiens_hsa04931 | 0.25753259 |
104 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.25500733 |
105 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23334295 |
106 | Lysosome_Homo sapiens_hsa04142 | 0.17741865 |
107 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.10630980 |
108 | Other glycan degradation_Homo sapiens_hsa00511 | 0.07281389 |
109 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.06597457 |
110 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.02281930 |
111 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.01496313 |
112 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.1884686 |
113 | Hepatitis C_Homo sapiens_hsa05160 | -0.1866582 |
114 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1547797 |
115 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | -0.1543844 |
116 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1505377 |
117 | Mineral absorption_Homo sapiens_hsa04978 | -0.1328546 |
118 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.1307901 |
119 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.1295780 |
120 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1121667 |
121 | Malaria_Homo sapiens_hsa05144 | -0.1001892 |
122 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0878135 |
123 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.0742157 |
124 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.0664065 |
125 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.0624476 |
126 | Pertussis_Homo sapiens_hsa05133 | -0.0440375 |
127 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0427668 |
128 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0122497 |