APOH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.59480829
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59480829
3L-phenylalanine metabolic process (GO:0006558)7.26538283
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26538283
5aromatic amino acid family catabolic process (GO:0009074)6.81048764
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.52645428
7exogenous drug catabolic process (GO:0042738)6.46855934
8indole-containing compound catabolic process (GO:0042436)6.11928140
9indolalkylamine catabolic process (GO:0046218)6.11928140
10tryptophan catabolic process (GO:0006569)6.11928140
11kynurenine metabolic process (GO:0070189)6.02293968
12epoxygenase P450 pathway (GO:0019373)6.00006410
13bile acid biosynthetic process (GO:0006699)5.96224361
14glyoxylate metabolic process (GO:0046487)5.85865642
15regulation of plasminogen activation (GO:0010755)5.82759420
16high-density lipoprotein particle remodeling (GO:0034375)5.76684500
17tryptophan metabolic process (GO:0006568)5.76660573
18urea cycle (GO:0000050)5.71070094
19urea metabolic process (GO:0019627)5.71070094
20alpha-linolenic acid metabolic process (GO:0036109)5.61826692
21intestinal cholesterol absorption (GO:0030299)5.61262480
22peptidyl-glutamic acid carboxylation (GO:0017187)5.45443627
23protein carboxylation (GO:0018214)5.45443627
24omega-hydroxylase P450 pathway (GO:0097267)5.41200011
25regulation of protein activation cascade (GO:2000257)5.40070361
26sulfur amino acid catabolic process (GO:0000098)5.38835792
27cysteine metabolic process (GO:0006534)5.37885474
28complement activation, alternative pathway (GO:0006957)5.37246719
29* negative regulation of fibrinolysis (GO:0051918)5.32469889
30nitrogen cycle metabolic process (GO:0071941)5.24895774
31* regulation of fibrinolysis (GO:0051917)5.23629698
32negative regulation of protein activation cascade (GO:2000258)5.20476398
33serine family amino acid catabolic process (GO:0009071)5.14132281
34bile acid metabolic process (GO:0008206)5.09917995
35reverse cholesterol transport (GO:0043691)5.07240948
36regulation of cholesterol esterification (GO:0010872)5.04362740
37regulation of apoptotic cell clearance (GO:2000425)5.03954404
38regulation of complement activation (GO:0030449)5.02658099
39aromatic amino acid family metabolic process (GO:0009072)4.95178703
40plasma lipoprotein particle remodeling (GO:0034369)4.94486102
41protein-lipid complex remodeling (GO:0034368)4.94486102
42macromolecular complex remodeling (GO:0034367)4.94486102
43regulation of triglyceride catabolic process (GO:0010896)4.94182909
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87810267
45tyrosine metabolic process (GO:0006570)4.82911450
46regulation of humoral immune response (GO:0002920)4.79051127
47homocysteine metabolic process (GO:0050667)4.76305042
48phospholipid efflux (GO:0033700)4.73826989
49triglyceride homeostasis (GO:0070328)4.70809233
50acylglycerol homeostasis (GO:0055090)4.70809233
51positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.67194360
52alpha-amino acid catabolic process (GO:1901606)4.64296864
53negative regulation of sterol transport (GO:0032372)4.63820047
54negative regulation of cholesterol transport (GO:0032375)4.63820047
55amino-acid betaine metabolic process (GO:0006577)4.62262366
56lysine metabolic process (GO:0006553)4.57027418
57lysine catabolic process (GO:0006554)4.57027418
58plasma lipoprotein particle clearance (GO:0034381)4.55012710
59* negative regulation of hemostasis (GO:1900047)4.54861110
60* negative regulation of blood coagulation (GO:0030195)4.54861110
61cellular ketone body metabolic process (GO:0046950)4.52856580
62glycine metabolic process (GO:0006544)4.44484088
63ethanol metabolic process (GO:0006067)4.42165186
64bile acid and bile salt transport (GO:0015721)4.40444810
65cholesterol efflux (GO:0033344)4.35607891
66imidazole-containing compound metabolic process (GO:0052803)4.34225048
67coenzyme catabolic process (GO:0009109)4.34021619
68indolalkylamine metabolic process (GO:0006586)4.33961851
69cellular amino acid catabolic process (GO:0009063)4.27365447
70drug metabolic process (GO:0017144)4.26971013
71glutamate metabolic process (GO:0006536)4.25212422
72cellular biogenic amine catabolic process (GO:0042402)4.24576398
73amine catabolic process (GO:0009310)4.24576398
74cellular glucuronidation (GO:0052695)4.22766918
75negative regulation of complement activation (GO:0045916)4.21277997
76serine family amino acid metabolic process (GO:0009069)4.19250298
77* negative regulation of coagulation (GO:0050819)4.15527851
78plasma lipoprotein particle assembly (GO:0034377)4.14768959
79low-density lipoprotein particle remodeling (GO:0034374)4.12291947
80fibrinolysis (GO:0042730)4.11798712
81benzene-containing compound metabolic process (GO:0042537)4.09637351
82ethanol oxidation (GO:0006069)4.06733090
83cellular modified amino acid catabolic process (GO:0042219)4.06701629
84dicarboxylic acid biosynthetic process (GO:0043650)4.06479301
85arginine metabolic process (GO:0006525)4.05989231
86* negative regulation of wound healing (GO:0061045)4.05306628
87aldehyde catabolic process (GO:0046185)4.05228107
88serine family amino acid biosynthetic process (GO:0009070)4.04991221
89ketone body metabolic process (GO:1902224)3.92106838
90* positive regulation of hemostasis (GO:1900048)3.90802938
91* positive regulation of blood coagulation (GO:0030194)3.90802938
92drug catabolic process (GO:0042737)3.88611007
93oxidative demethylation (GO:0070989)3.87271133
94negative regulation of lipase activity (GO:0060192)3.82802692
95phospholipid homeostasis (GO:0055091)3.82710959
96positive regulation of lipid catabolic process (GO:0050996)3.82271539
97cofactor catabolic process (GO:0051187)3.80934654
98phenylpropanoid metabolic process (GO:0009698)3.80823822
99cholesterol homeostasis (GO:0042632)3.80341962
100very-low-density lipoprotein particle assembly (GO:0034379)3.80237167
101complement activation, classical pathway (GO:0006958)3.78113057
102plasma lipoprotein particle organization (GO:0071827)3.75899016
103glucuronate metabolic process (GO:0019585)3.74971954
104uronic acid metabolic process (GO:0006063)3.74971954
105complement activation (GO:0006956)3.74649173
106organic acid catabolic process (GO:0016054)3.74043016
107carboxylic acid catabolic process (GO:0046395)3.74043016
108sterol homeostasis (GO:0055092)3.73984983
109protein-lipid complex assembly (GO:0065005)3.71799709
110lipoprotein metabolic process (GO:0042157)3.70384187
111cytolysis (GO:0019835)3.67230890
112regulation of bile acid biosynthetic process (GO:0070857)3.66870363
113* protein activation cascade (GO:0072376)3.66132942
114short-chain fatty acid metabolic process (GO:0046459)3.64627275
115acetyl-CoA metabolic process (GO:0006084)3.63307597
116* blood coagulation, intrinsic pathway (GO:0007597)3.62245828
117disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.61886608
118killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.61886608
119positive regulation of fatty acid biosynthetic process (GO:0045723)3.61711269
120regulation of cholesterol homeostasis (GO:2000188)3.60541490
121* positive regulation of coagulation (GO:0050820)3.56758725
122NAD biosynthetic process (GO:0009435)3.54964519
123intestinal absorption (GO:0050892)3.53904930
124acute inflammatory response (GO:0002526)3.53639664
125protein-lipid complex subunit organization (GO:0071825)3.53456867
126acute-phase response (GO:0006953)3.53147476
127cholesterol transport (GO:0030301)3.53112319
128sterol transport (GO:0015918)3.53112319
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.51969420
130proline metabolic process (GO:0006560)3.47713869
131response to mercury ion (GO:0046689)3.44000158
132doxorubicin metabolic process (GO:0044598)3.41685316
133daunorubicin metabolic process (GO:0044597)3.41685316
134polyketide metabolic process (GO:0030638)3.41685316
135positive regulation of extracellular matrix organization (GO:1903055)3.39203260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.39624835
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21622402
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.05552533
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51555483
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29490613
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.09178359
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86657718
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03491767
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03321200
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07865946
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00802398
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0590380
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96463264
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79338896
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59911130
16HTT_18923047_ChIP-ChIP_STHdh_Human1.57145255
17CLOCK_20551151_ChIP-Seq_293T_Human1.53962507
18GATA1_22025678_ChIP-Seq_K562_Human1.46940092
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40128897
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.30026377
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29072024
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19439434
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.18756812
24* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18472791
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18103551
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16238439
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12427992
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00694646
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00296047
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96500463
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93211451
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89362529
33TP63_17297297_ChIP-ChIP_HaCaT_Human0.88519336
34* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88216803
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85881196
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85537203
37IRF8_22096565_ChIP-ChIP_GC-B_Human0.83758099
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83448340
39AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83300848
40HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83004089
41AR_21909140_ChIP-Seq_LNCAP_Human0.82101197
42RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81745122
43GATA4_25053715_ChIP-Seq_YYC3_Human0.79738717
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79648742
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78233018
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76613278
47PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76490461
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75785365
49* SOX2_20726797_ChIP-Seq_SW620_Human0.75618179
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75377432
51ZNF263_19887448_ChIP-Seq_K562_Human0.75198849
52RARA_24833708_ChIP-Seq_LIVER_Mouse0.74807002
53POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71728066
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71462310
55CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71454915
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.70485028
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70107584
58GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69920593
59SMAD1_18555785_Chip-Seq_ESCs_Mouse0.66953805
60NFIB_24661679_ChIP-Seq_LUNG_Mouse0.66776990
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66651457
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66135663
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.64539677
64NFE2_27457419_Chip-Seq_LIVER_Mouse0.63796602
65ESR2_21235772_ChIP-Seq_MCF-7_Human0.63752085
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63445874
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63445874
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62921653
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62907984
70RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61858142
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61707006
72* RARB_24833708_ChIP-Seq_LIVER_Mouse0.61542441
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60624538
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59762862
75RAC3_21632823_ChIP-Seq_H3396_Human0.58189549
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.57712520
77ESRRB_18555785_Chip-Seq_ESCs_Mouse0.57506532
78CEBPB_22108803_ChIP-Seq_LS180_Human0.57489247
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.56646410
80CTNNB1_20460455_ChIP-Seq_HCT116_Human0.56464557
81EGR1_19032775_ChIP-ChIP_M12_Human0.55208948
82* SOX2_21211035_ChIP-Seq_LN229_Human0.54952703
83DNAJC2_21179169_ChIP-ChIP_NT2_Human0.54084553
84RUNX1_27457419_Chip-Seq_LIVER_Mouse0.54057654
85CSB_26484114_Chip-Seq_FIBROBLAST_Human0.53326774
86LXR_22292898_ChIP-Seq_THP-1_Human0.53141867
87NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.52879293
88OCT4_18555785_Chip-Seq_ESCs_Mouse0.52723874
89FOXA1_25552417_ChIP-Seq_VCAP_Human0.52592643
90AR_20517297_ChIP-Seq_VCAP_Human0.52460582
91* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.52437345
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.52138661
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51930707
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51392680
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50918432
96ZFX_18555785_Chip-Seq_ESCs_Mouse0.50459916
97GATA3_24758297_ChIP-Seq_MCF-7_Human0.50437234
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50095704
99* MYC_19915707_ChIP-ChIP_AK7_Human0.49849331
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.49828139
101TP53_16413492_ChIP-PET_HCT116_Human0.49233679
102SOX11_22085726_ChIP-Seq_ESNs_Mouse0.49008331
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.48694238
104ESET_19884257_ChIP-Seq_ESCs_Mouse0.48510219
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.48213586
106CBP_21632823_ChIP-Seq_H3396_Human0.47976843
107PU1_27457419_Chip-Seq_LIVER_Mouse0.47746624
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47633804
109P53_21459846_ChIP-Seq_SAOS-2_Human0.46972772
110STAT1_17558387_ChIP-Seq_HELA_Human0.46820969
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46288874
112GATA1_19941826_ChIP-Seq_K562_Human0.45357541
113PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45303313
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.44816204
115TAF15_26573619_Chip-Seq_HEK293_Human0.43531700
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43442250
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.42635479
118TAF2_19829295_ChIP-Seq_ESCs_Human0.42626947
119GATA2_19941826_ChIP-Seq_K562_Human0.41265249
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.41000263
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40786764
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40362426
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.40029149
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.39156443
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39128983
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38847023
127GATA6_25053715_ChIP-Seq_YYC3_Human0.38051087
128BCAT_22108803_ChIP-Seq_LS180_Human0.37972351
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.37795250
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.37573481
131LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36030495
132ERG_20517297_ChIP-Seq_VCAP_Human0.34733966
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34588638
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34056099
135NCOR_22424771_ChIP-Seq_293T_Human0.33662584
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.33637824
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.33109383
138* SPI1_26923725_Chip-Seq_HPCs_Mouse0.33057096
139SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32620874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.31738429
2MP0005360_urolithiasis7.53267760
3MP0005085_abnormal_gallbladder_physiolo6.43511010
4MP0005365_abnormal_bile_salt6.18663893
5MP0008875_abnormal_xenobiotic_pharmacok5.09045059
6MP0003806_abnormal_nucleotide_metabolis4.26925753
7MP0003252_abnormal_bile_duct3.89071839
8MP0010329_abnormal_lipoprotein_level3.63473442
9MP0009840_abnormal_foam_cell3.36619079
10MP0005083_abnormal_biliary_tract3.10520318
11MP0003195_calcinosis2.81626203
12MP0005332_abnormal_amino_acid2.74894008
13MP0001666_abnormal_nutrient_absorption2.58649935
14MP0003122_maternal_imprinting2.52340128
15MP0003191_abnormal_cellular_cholesterol2.41617186
16MP0000609_abnormal_liver_physiology2.17817692
17MP0004019_abnormal_vitamin_homeostasis2.12798478
18MP0002118_abnormal_lipid_homeostasis2.10670494
19MP0002138_abnormal_hepatobiliary_system1.96864536
20MP0003868_abnormal_feces_composition1.92734613
21MP0005319_abnormal_enzyme/_coenzyme1.82700353
22MP0001764_abnormal_homeostasis1.69064748
23MP0009697_abnormal_copulation1.64353974
24MP0005584_abnormal_enzyme/coenzyme_acti1.57671569
25MP0001915_intracranial_hemorrhage1.49720320
26MP0003011_delayed_dark_adaptation1.46122957
27MP0005451_abnormal_body_composition1.45048651
28MP0003656_abnormal_erythrocyte_physiolo1.33466575
29MP0000566_synostosis1.31064934
30MP0003186_abnormal_redox_activity1.27345021
31MP0005058_abnormal_lysosome_morphology1.23022206
32MP0009643_abnormal_urine_homeostasis1.22016111
33MP0003123_paternal_imprinting1.21091984
34MP0000598_abnormal_liver_morphology1.18773430
35MP0002089_abnormal_postnatal_growth/wei1.17347604
36MP0003705_abnormal_hypodermis_morpholog1.15308919
37MP0005647_abnormal_sex_gland1.13056332
38MP0000604_amyloidosis1.12560957
39MP0003172_abnormal_lysosome_physiology1.10307274
40MP0009764_decreased_sensitivity_to1.05534596
41MP0002254_reproductive_system_inflammat1.03637065
42MP0009763_increased_sensitivity_to1.02653286
43MP0010368_abnormal_lymphatic_system0.99368675
44MP0005636_abnormal_mineral_homeostasis0.93168510
45MP0008469_abnormal_protein_level0.89412018
46* MP0009642_abnormal_blood_homeostasis0.86537574
47MP0005408_hypopigmentation0.85123041
48MP0006036_abnormal_mitochondrial_physio0.82518943
49MP0005376_homeostasis/metabolism_phenot0.81017111
50MP0009765_abnormal_xenobiotic_induced0.78528753
51MP0002078_abnormal_glucose_homeostasis0.78009590
52MP0005084_abnormal_gallbladder_morpholo0.76933336
53MP0002876_abnormal_thyroid_physiology0.75219656
54MP0005670_abnormal_white_adipose0.74871988
55MP0005220_abnormal_exocrine_pancreas0.71715958
56MP0009780_abnormal_chondrocyte_physiolo0.71273800
57MP0002971_abnormal_brown_adipose0.70757201
58MP0005409_darkened_coat_color0.70230515
59MP0003879_abnormal_hair_cell0.68849803
60MP0004130_abnormal_muscle_cell0.68547421
61MP0005334_abnormal_fat_pad0.67990401
62MP0003690_abnormal_glial_cell0.67922135
63MP0009053_abnormal_anal_canal0.67294706
64MP0001661_extended_life_span0.66947601
65MP0005535_abnormal_body_temperature0.66409570
66MP0005266_abnormal_metabolism0.64672292
67MP0003329_amyloid_beta_deposits0.63795104
68MP0004272_abnormal_basement_membrane0.63780379
69MP0000639_abnormal_adrenal_gland0.62585559
70MP0001756_abnormal_urination0.58076316
71MP0002282_abnormal_trachea_morphology0.57731403
72MP0005167_abnormal_blood-brain_barrier0.57543983
73MP0006035_abnormal_mitochondrial_morpho0.56537180
74MP0005464_abnormal_platelet_physiology0.56494614
75MP0005448_abnormal_energy_balance0.55394931
76MP0006054_spinal_hemorrhage0.54790148
77MP0003121_genomic_imprinting0.54788304
78MP0005257_abnormal_intraocular_pressure0.50116403
79MP0002909_abnormal_adrenal_gland0.49994871
80MP0002822_catalepsy0.49075492
81MP0005395_other_phenotype0.48804451
82MP0005023_abnormal_wound_healing0.48752964
83MP0003718_maternal_effect0.45970651
84MP0003638_abnormal_response/metabolism_0.45305949
85MP0008874_decreased_physiological_sensi0.45112370
86MP0008873_increased_physiological_sensi0.44758071
87MP0005187_abnormal_penis_morphology0.44430794
88MP0002928_abnormal_bile_duct0.44023494
89MP0002136_abnormal_kidney_physiology0.43960305
90MP0003632_abnormal_nervous_system0.43836445
91MP0003436_decreased_susceptibility_to0.42224633
92MP0004782_abnormal_surfactant_physiolog0.41981477
93MP0002837_dystrophic_cardiac_calcinosis0.41650133
94MP0003075_altered_response_to0.41629757
95MP0003567_abnormal_fetal_cardiomyocyte0.41506892
96MP0000920_abnormal_myelination0.41408747
97MP0003724_increased_susceptibility_to0.40586286
98MP0003953_abnormal_hormone_level0.40394458
99MP0003183_abnormal_peptide_metabolism0.39967043
100MP0003950_abnormal_plasma_membrane0.38657904
101MP0005248_abnormal_Harderian_gland0.38460399
102MP0002933_joint_inflammation0.38381683
103MP0004381_abnormal_hair_follicle0.38171482
104MP0005166_decreased_susceptibility_to0.38098089
105MP0008872_abnormal_physiological_respon0.38036402
106MP0009672_abnormal_birth_weight0.37108772
107MP0001324_abnormal_eye_pigmentation0.36757247
108MP0005666_abnormal_adipose_tissue0.36264053
109MP0003878_abnormal_ear_physiology0.35975896
110MP0005377_hearing/vestibular/ear_phenot0.35975896
111MP0004883_abnormal_blood_vessel0.34737617
112MP0005379_endocrine/exocrine_gland_phen0.34094069
113MP0000249_abnormal_blood_vessel0.33220242
114MP0002796_impaired_skin_barrier0.33114841
115MP0000003_abnormal_adipose_tissue0.33049786
116MP0000579_abnormal_nail_morphology0.32939069
117MP0001243_abnormal_dermal_layer0.32507731
118MP0009115_abnormal_fat_cell0.32440083
119MP0006082_CNS_inflammation0.31688536
120MP0003633_abnormal_nervous_system0.31495723
121MP0001270_distended_abdomen0.31331005
122MP0005410_abnormal_fertilization0.30917656
123MP0000230_abnormal_systemic_arterial0.30703638
124MP0003566_abnormal_cell_adhesion0.30155420
125MP0003943_abnormal_hepatobiliary_system0.29951289
126MP0003631_nervous_system_phenotype0.29894259
127MP0002168_other_aberrant_phenotype0.29813563
128MP0002970_abnormal_white_adipose0.29727692
129MP0001853_heart_inflammation0.29580130
130MP0009384_cardiac_valve_regurgitation0.28991634
131MP0001845_abnormal_inflammatory_respons0.28350997
132MP0003941_abnormal_skin_development0.28153681
133MP0002128_abnormal_blood_circulation0.28042070
134MP0002249_abnormal_larynx_morphology0.27524929
135MP0001881_abnormal_mammary_gland0.27127139
136MP0005164_abnormal_response_to0.26986993
137MP0002132_abnormal_respiratory_system0.25933335
138MP0002090_abnormal_vision0.23755331
139MP0002060_abnormal_skin_morphology0.22558442

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.53358450
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.39142602
3Intrahepatic cholestasis (HP:0001406)7.30421024
4Prolonged partial thromboplastin time (HP:0003645)6.67001326
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64532434
6Hypobetalipoproteinemia (HP:0003563)6.47484557
7Xanthomatosis (HP:0000991)6.33199633
8Hyperlipoproteinemia (HP:0010980)5.60148472
9Complement deficiency (HP:0004431)5.38713135
10Joint hemorrhage (HP:0005261)4.90649658
11Hypolipoproteinemia (HP:0010981)4.89321735
12Hyperammonemia (HP:0001987)4.60957201
13Abnormality of the common coagulation pathway (HP:0010990)4.55687648
14Epidermoid cyst (HP:0200040)4.47935725
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.46574420
16Hyperglycinemia (HP:0002154)4.38979952
17Hypoalphalipoproteinemia (HP:0003233)4.30741200
18Abnormality of methionine metabolism (HP:0010901)4.29555040
19Ketosis (HP:0001946)4.24578041
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.23205963
21Fat malabsorption (HP:0002630)4.11693719
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11461870
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10468459
24Abnormality of complement system (HP:0005339)3.93344610
25Hypoglycemic coma (HP:0001325)3.87770870
26Abnormality of serine family amino acid metabolism (HP:0010894)3.87729073
27Abnormality of glycine metabolism (HP:0010895)3.87729073
28Hyperglycinuria (HP:0003108)3.87037630
29Abnormality of pyrimidine metabolism (HP:0004353)3.83298544
30Abnormality of the intrinsic pathway (HP:0010989)3.82653838
31Conjugated hyperbilirubinemia (HP:0002908)3.67134980
32Hypercholesterolemia (HP:0003124)3.63412873
33Hyperbilirubinemia (HP:0002904)3.37054094
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35416881
35Abnormality of fatty-acid metabolism (HP:0004359)3.32805488
36Spontaneous abortion (HP:0005268)3.13507048
37Purpura (HP:0000979)3.09953918
38Steatorrhea (HP:0002570)3.09324239
39Hypochromic microcytic anemia (HP:0004840)3.07480540
40Delayed CNS myelination (HP:0002188)3.07313928
41Abnormality of serum amino acid levels (HP:0003112)3.05912108
42Abnormality of nucleobase metabolism (HP:0010932)3.03595284
43Hepatocellular carcinoma (HP:0001402)3.02195637
44Ketoacidosis (HP:0001993)2.97613101
45Myocardial infarction (HP:0001658)2.90776671
46Metabolic acidosis (HP:0001942)2.76314890
47Skin nodule (HP:0200036)2.76308677
48Systemic lupus erythematosus (HP:0002725)2.71531077
49Osteomalacia (HP:0002749)2.67055822
50Acanthocytosis (HP:0001927)2.66409199
51Abnormality of purine metabolism (HP:0004352)2.63743654
52Lethargy (HP:0001254)2.59391895
53Dicarboxylic aciduria (HP:0003215)2.57146652
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57146652
55Vascular calcification (HP:0004934)2.55658275
56Abnormal gallbladder morphology (HP:0012437)2.50776589
57Glomerulonephritis (HP:0000099)2.49122460
58Hypoglycemic seizures (HP:0002173)2.48402467
59Arthropathy (HP:0003040)2.45072488
60Cholelithiasis (HP:0001081)2.44975326
61Spastic diplegia (HP:0001264)2.44602628
62Cerebral edema (HP:0002181)2.42773170
63Abnormal gallbladder physiology (HP:0012438)2.41812696
64Cholecystitis (HP:0001082)2.41812696
65Gout (HP:0001997)2.40890758
66Recurrent gram-negative bacterial infections (HP:0005420)2.38529453
67Amyloidosis (HP:0011034)2.38342271
68Mitral stenosis (HP:0001718)2.38015298
69Abnormal tarsal ossification (HP:0008369)2.36991025
70Abnormality of carpal bone ossification (HP:0006257)2.35380259
71Neonatal onset (HP:0003623)2.33972405
72Irritability (HP:0000737)2.33776341
73Gingival bleeding (HP:0000225)2.29584903
74Cardiovascular calcification (HP:0011915)2.26599663
75Malnutrition (HP:0004395)2.24621175
76Esophageal varix (HP:0002040)2.22166116
77Pulmonary embolism (HP:0002204)2.20037966
78Menorrhagia (HP:0000132)2.19651524
79Pancreatitis (HP:0001733)2.14984761
80Thrombophlebitis (HP:0004418)2.13990784
81Sensorimotor neuropathy (HP:0007141)2.12341988
82Enlarged kidneys (HP:0000105)2.11578089
83Poikilocytosis (HP:0004447)2.11432411
84Brushfield spots (HP:0001088)2.10661594
85Late onset (HP:0003584)2.09406556
86Increased serum pyruvate (HP:0003542)2.07776192
87Vomiting (HP:0002013)2.05915827
88Abnormality of the gallbladder (HP:0005264)2.03026920
89Generalized aminoaciduria (HP:0002909)2.02040801
90Hyperinsulinemic hypoglycemia (HP:0000825)2.01170821
91Hemorrhage of the eye (HP:0011885)2.00252167
92Opisthotonus (HP:0002179)2.00233757
93Abnormality of the Achilles tendon (HP:0005109)1.99172152
94Pancreatic islet-cell hyperplasia (HP:0004510)1.96677494
95Broad alveolar ridges (HP:0000187)1.92425080
96Rickets (HP:0002748)1.92326340
97Abnormality of iron homeostasis (HP:0011031)1.92043699
98Reduced antithrombin III activity (HP:0001976)1.91988156
99Abnormality of transition element cation homeostasis (HP:0011030)1.88831239
100Bifid scrotum (HP:0000048)1.88224620
101Abnormal cartilage morphology (HP:0002763)1.86887240
102Abnormality of glycolysis (HP:0004366)1.86534502
103Renal cortical cysts (HP:0000803)1.84596421
104Facial shape deformation (HP:0011334)1.84489774
105Potter facies (HP:0002009)1.84489774
106Flat acetabular roof (HP:0003180)1.83648819
107Hypophosphatemic rickets (HP:0004912)1.83133675
108Joint swelling (HP:0001386)1.82915184
109Hydroxyprolinuria (HP:0003080)1.82156830
110Abnormality of proline metabolism (HP:0010907)1.82156830
111Elevated hepatic transaminases (HP:0002910)1.80994363
112Abnormal enzyme/coenzyme activity (HP:0012379)1.79120209
113Alkalosis (HP:0001948)1.78058428
114Epistaxis (HP:0000421)1.77789954
115Status epilepticus (HP:0002133)1.77599366
116Nephritis (HP:0000123)1.76230559
117Small epiphyses (HP:0010585)1.74846926
118Reticulocytosis (HP:0001923)1.72488591
119Hyperphosphaturia (HP:0003109)1.71633943
120Abnormality of vitamin metabolism (HP:0100508)1.71443852
121Abnormal hand bone ossification (HP:0010660)1.71047586
122Fair hair (HP:0002286)1.70586949
123Abnormal delivery (HP:0001787)1.69987020
124Glycosuria (HP:0003076)1.68034938
125Abnormality of urine glucose concentration (HP:0011016)1.68034938
126Abnormality of the lumbar spine (HP:0100712)1.67277015
127Abnormal ossification of hand bones (HP:0005921)1.67013944
128Vaginal fistula (HP:0004320)1.65016304
129Gangrene (HP:0100758)1.64214271
130Hepatoblastoma (HP:0002884)1.56816653
131Abnormality of the nasal septum (HP:0000419)1.56145232
132Proximal tubulopathy (HP:0000114)1.53836003
133Submucous cleft hard palate (HP:0000176)1.53640632
134Increased serum ferritin (HP:0003281)1.51063139
135Mucopolysacchariduria (HP:0008155)1.48328810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.28589277
2FGFR44.63408019
3SIK14.53956107
4ERN14.35807893
5TAOK33.05734717
6WNK43.00720876
7INSRR2.96212255
8ERBB42.87966788
9CDK122.79323260
10PIK3CA2.64173663
11MAP2K42.35667340
12PKN22.27776655
13MST1R2.14848909
14TYRO32.07197326
15FGFR11.99957043
16FLT31.94985944
17MAPK111.91606941
18PIK3CG1.87626291
19PDGFRA1.87307096
20TRIB31.81303556
21TYK21.71987792
22AKT31.63920122
23LATS11.62296511
24EIF2AK11.58957836
25DAPK21.57792009
26ABL21.49332561
27PTK61.47481339
28NEK91.42990208
29WNK11.36539236
30FGFR21.35699271
31KDR1.35269211
32FRK1.32762429
33MAP3K21.32283825
34JAK21.23102825
35SIK21.16918402
36MAP3K71.16596026
37PINK11.14699681
38PRKAA21.11461354
39GRK61.10658359
40MAP2K31.10196134
41TBK11.05243840
42NTRK31.05065643
43MAP3K101.01195214
44ERBB21.01183775
45JAK11.01136470
46MAPK40.98983273
47EEF2K0.97675192
48MAP3K140.92949845
49PRKCZ0.91684428
50MAPKAPK30.89727663
51MAP3K30.88401603
52MET0.87949705
53DDR20.86983886
54STK38L0.84922799
55EPHB10.84882033
56MAP3K110.83225666
57CDK60.81778409
58MAPK120.81335134
59CSNK1E0.81324796
60TIE10.79140208
61SGK10.78473577
62MAPK150.78104167
63PRKACG0.77849100
64CDK70.76307714
65EPHA30.76059949
66DYRK1B0.71313634
67RPS6KB10.71284770
68CAMK2G0.71011237
69CSK0.69661243
70CAMK1D0.67637999
71GSK3A0.67572951
72MAP2K60.66844957
73KSR20.66483748
74PRKAA10.65172642
75FGR0.64482110
76BCR0.64332638
77RIPK10.60802895
78SGK30.60730812
79TGFBR20.59672562
80CDC42BPA0.58516734
81CSNK1D0.57559801
82CSF1R0.57352664
83BRSK20.57077271
84PTK20.56583670
85MAPK70.56438055
86FGFR30.55632440
87IRAK30.55040480
88NLK0.54290592
89NEK10.53358073
90IKBKE0.53300784
91PRKCQ0.51754391
92PDPK10.51658919
93PRKG10.50791969
94BRSK10.49155228
95TAOK20.47956031
96EPHA40.47558790
97CSNK1G10.47018737
98SRC0.46186324
99MAP3K50.45162178
100GRK10.45146285
101MAP2K10.43724332
102IGF1R0.43375781
103BRD40.43211791
104SGK20.43064464
105RPS6KA30.42837113
106CDK40.42798199
107RET0.42590262
108PRKCG0.42233384
109EPHA20.41148337
110STK390.40975602
111CSNK2A20.40927541
112SCYL20.40461931
113ICK0.39848305
114PBK0.39432282
115MAP3K130.38680385
116PKN10.38232904
117MAP3K60.38107729
118CSNK2A10.36774841
119FER0.35791986
120MTOR0.34826649
121EGFR0.34290322
122PDK10.33110924
123PRKACA0.33098004
124MATK0.32486737
125CAMK40.31884157
126SGK2230.31441035
127SGK4940.31441035
128PRKCB0.31385365
129PRKACB0.30341709
130CAMKK20.28566901
131NEK20.28217739
132MAP3K10.28015069
133CSNK1G20.26884818
134YES10.26216071
135MAPK30.26208219
136PRKCA0.25993391
137LATS20.25126286
138CSNK1G30.24199272
139PDK30.22786153
140PDK40.22786153
141MAP2K20.22286961
142PAK30.21663795
143IRAK10.21356745
144BMX0.21165237
145ABL10.20357505
146IRAK20.20217260

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.52255386
2Nitrogen metabolism_Homo sapiens_hsa009103.65009482
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40172904
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33590363
5Arginine biosynthesis_Homo sapiens_hsa002203.08376586
6Complement and coagulation cascades_Homo sapiens_hsa046102.82288354
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69424789
8Tryptophan metabolism_Homo sapiens_hsa003802.67187350
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64680076
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55331303
11Fatty acid degradation_Homo sapiens_hsa000712.49346180
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37891229
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22487077
14Butanoate metabolism_Homo sapiens_hsa006502.15594868
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12005917
16Peroxisome_Homo sapiens_hsa041462.06632553
17Chemical carcinogenesis_Homo sapiens_hsa052041.94090608
18Propanoate metabolism_Homo sapiens_hsa006401.92337613
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.91715913
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91405203
21Histidine metabolism_Homo sapiens_hsa003401.88777385
22PPAR signaling pathway_Homo sapiens_hsa033201.86946387
23Fatty acid metabolism_Homo sapiens_hsa012121.81710976
24Staphylococcus aureus infection_Homo sapiens_hsa051501.78318235
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.74917179
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74744891
27Caffeine metabolism_Homo sapiens_hsa002321.71402615
28beta-Alanine metabolism_Homo sapiens_hsa004101.70373821
29Retinol metabolism_Homo sapiens_hsa008301.69422270
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64224207
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63826279
32Selenocompound metabolism_Homo sapiens_hsa004501.58002864
33Phenylalanine metabolism_Homo sapiens_hsa003601.56046889
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51128035
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50600021
36Bile secretion_Homo sapiens_hsa049761.47811212
37Tyrosine metabolism_Homo sapiens_hsa003501.44255289
38Pyruvate metabolism_Homo sapiens_hsa006201.36126922
39Fatty acid elongation_Homo sapiens_hsa000621.35404686
40Sulfur metabolism_Homo sapiens_hsa009201.35143019
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32590462
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27050897
43Steroid biosynthesis_Homo sapiens_hsa001001.21688526
44Biosynthesis of amino acids_Homo sapiens_hsa012301.20804597
45Folate biosynthesis_Homo sapiens_hsa007901.20242322
46Fat digestion and absorption_Homo sapiens_hsa049751.19140521
47ABC transporters_Homo sapiens_hsa020101.18728911
48Carbon metabolism_Homo sapiens_hsa012001.13306128
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02426279
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00389337
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.99712701
52Vitamin B6 metabolism_Homo sapiens_hsa007500.99266105
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.98325325
54Arginine and proline metabolism_Homo sapiens_hsa003300.96367443
55Sulfur relay system_Homo sapiens_hsa041220.95777954
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86788042
57Vitamin digestion and absorption_Homo sapiens_hsa049770.86677090
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82577943
59Lysine degradation_Homo sapiens_hsa003100.80368702
60One carbon pool by folate_Homo sapiens_hsa006700.76646665
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70705668
62Glycerolipid metabolism_Homo sapiens_hsa005610.66755993
63Glutathione metabolism_Homo sapiens_hsa004800.64604583
64Other glycan degradation_Homo sapiens_hsa005110.61413338
65Pentose phosphate pathway_Homo sapiens_hsa000300.59265003
66Fatty acid biosynthesis_Homo sapiens_hsa000610.53949106
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46921635
68Metabolic pathways_Homo sapiens_hsa011000.45911748
69Pertussis_Homo sapiens_hsa051330.44764374
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39329733
71Prion diseases_Homo sapiens_hsa050200.36414564
72Galactose metabolism_Homo sapiens_hsa000520.26270061
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26029349
74Fructose and mannose metabolism_Homo sapiens_hsa000510.24220816
75Linoleic acid metabolism_Homo sapiens_hsa005910.23199905
76N-Glycan biosynthesis_Homo sapiens_hsa005100.22539695
77Insulin resistance_Homo sapiens_hsa049310.22456001
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.21337387
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21210002
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.15738880
81Mineral absorption_Homo sapiens_hsa049780.10124252
82Glucagon signaling pathway_Homo sapiens_hsa049220.09537369
83AMPK signaling pathway_Homo sapiens_hsa041520.01525670
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2461620
85Amoebiasis_Homo sapiens_hsa05146-0.2430110
86Ether lipid metabolism_Homo sapiens_hsa00565-0.2403826
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2375930
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2270576
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2001477
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1953148
91Lysosome_Homo sapiens_hsa04142-0.1933781
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1863688
93Renin-angiotensin system_Homo sapiens_hsa04614-0.1851889
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1843052
95Hepatitis C_Homo sapiens_hsa05160-0.1805665
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1609421
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1608227
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1579501
99Regulation of autophagy_Homo sapiens_hsa04140-0.1475614
100Circadian rhythm_Homo sapiens_hsa04710-0.1398811
101African trypanosomiasis_Homo sapiens_hsa05143-0.1296933
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1158642
103ECM-receptor interaction_Homo sapiens_hsa04512-0.1139028
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1045259
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0925519
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0703285
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0697487
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0410249
109Sphingolipid metabolism_Homo sapiens_hsa00600-0.0113174

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