APOL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type I interferon signaling pathway (GO:0060337)4.98021058
2cellular response to type I interferon (GO:0071357)4.98021058
3response to type I interferon (GO:0034340)4.97616384
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33350524
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19169806
6negative regulation of cell killing (GO:0031342)4.17657537
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17657537
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10603785
9negative regulation of interleukin-12 production (GO:0032695)4.05180656
10positive regulation of gamma-delta T cell activation (GO:0046645)4.04806814
11antigen processing and presentation of endogenous antigen (GO:0019883)3.99641198
12regulation of T-helper 1 cell differentiation (GO:0045625)3.95478090
13negative regulation of viral genome replication (GO:0045071)3.94396905
14regulation of interferon-alpha production (GO:0032647)3.83127656
15immunoglobulin mediated immune response (GO:0016064)3.82821065
16interferon-gamma-mediated signaling pathway (GO:0060333)3.80104924
17regulation of chronic inflammatory response (GO:0002676)3.56847766
18positive regulation of interferon-alpha production (GO:0032727)3.51054193
19regulation of regulatory T cell differentiation (GO:0045589)3.49992629
20response to interferon-beta (GO:0035456)3.48961298
21macrophage activation involved in immune response (GO:0002281)3.45614829
22regulation of T cell tolerance induction (GO:0002664)3.33617031
23regulation of interferon-beta biosynthetic process (GO:0045357)3.33418371
24response to peptidoglycan (GO:0032494)3.32266531
25defense response to protozoan (GO:0042832)3.32039620
26response to interferon-alpha (GO:0035455)3.30658225
27positive regulation of defense response to virus by host (GO:0002230)3.21743744
28regulation of antigen processing and presentation (GO:0002577)3.20990909
29cytidine metabolic process (GO:0046087)3.19201735
30cytidine catabolic process (GO:0006216)3.19201735
31cytidine deamination (GO:0009972)3.19201735
32modulation by symbiont of host immune response (GO:0052553)3.18267943
33positive regulation by symbiont of host defense response (GO:0052509)3.18267943
34modulation by symbiont of host defense response (GO:0052031)3.18267943
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18267943
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18267943
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.18267943
38positive regulation of type 2 immune response (GO:0002830)3.17217890
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16679272
40negative regulation of cytokine production involved in immune response (GO:0002719)3.16324739
41positive regulation of antigen processing and presentation (GO:0002579)3.15742971
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15314886
43response to protozoan (GO:0001562)3.11236978
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10946994
45myeloid dendritic cell differentiation (GO:0043011)3.09789469
46detection of other organism (GO:0098543)3.08902686
47T cell migration (GO:0072678)3.07207714
48lymphocyte chemotaxis (GO:0048247)3.03986112
49germinal center formation (GO:0002467)3.02066378
50cellular response to interferon-gamma (GO:0071346)3.01231636
51regulation of gamma-delta T cell activation (GO:0046643)3.00811888
52regulation of T cell mediated cytotoxicity (GO:0001914)2.99783607
53NIK/NF-kappaB signaling (GO:0038061)2.98633281
54detection of bacterium (GO:0016045)2.97893073
55T-helper 1 type immune response (GO:0042088)2.96529832
56response to interferon-gamma (GO:0034341)2.95715356
57negative regulation of innate immune response (GO:0045824)2.93499105
58B cell mediated immunity (GO:0019724)2.90303716
59regulation of type 2 immune response (GO:0002828)2.86900953
60interferon-gamma secretion (GO:0072643)2.86778630
61regulation of tolerance induction (GO:0002643)2.86213544
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85785091
63positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84639216
64regulation of vitamin D biosynthetic process (GO:0060556)2.84162063
65myeloid dendritic cell activation (GO:0001773)2.83838253
66pyrimidine ribonucleoside catabolic process (GO:0046133)2.83006396
67regulation of interleukin-12 production (GO:0032655)2.79899883
68detection of molecule of bacterial origin (GO:0032490)2.79368041
69defense response to virus (GO:0051607)2.79022819
70response to interleukin-15 (GO:0070672)2.76080036
71detection of external biotic stimulus (GO:0098581)2.75849094
72positive regulation of interferon-beta production (GO:0032728)2.75819945
73regulation of cytokine secretion involved in immune response (GO:0002739)2.75699048
74regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74858027
75positive regulation of tolerance induction (GO:0002645)2.74034675
76neutrophil activation involved in immune response (GO:0002283)2.73256329
77cellular response to interferon-beta (GO:0035458)2.71071714
78production of molecular mediator involved in inflammatory response (GO:0002532)2.69671785
79cellular response to interleukin-15 (GO:0071350)2.69631158
80positive regulation of interleukin-1 beta secretion (GO:0050718)2.68811519
81regulation of T-helper 2 cell differentiation (GO:0045628)2.66966375
82regulation of B cell receptor signaling pathway (GO:0050855)2.66711253
83negative regulation of T cell mediated immunity (GO:0002710)2.66559282
84regulation of mononuclear cell migration (GO:0071675)2.66484513
85negative regulation of viral process (GO:0048525)2.66383933
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66130278
87eosinophil chemotaxis (GO:0048245)2.65365914
88regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63464367
89regulation of natural killer cell mediated immunity (GO:0002715)2.63464367
90regulation of interleukin-1 beta secretion (GO:0050706)2.61035896
91negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.60260373
92regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.60206294
93positive regulation of interleukin-1 secretion (GO:0050716)2.59794880
94regulation of T-helper cell differentiation (GO:0045622)2.59540912
95regulation of viral genome replication (GO:0045069)2.58923218
96negative regulation of type I interferon production (GO:0032480)2.58129020
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57186059
98regulation of leukocyte mediated cytotoxicity (GO:0001910)2.57014882
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.56244395
100granulocyte activation (GO:0036230)2.55709544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.38382640
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.44530333
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.52030333
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.51112987
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.66443413
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.60343714
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.51836966
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.07764670
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.05544092
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.75027665
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65704972
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55563127
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42001066
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36471764
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35217820
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25255833
17RUNX_20019798_ChIP-Seq_JUKART_Human2.13963591
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99181011
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96435067
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89244568
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75371501
22MYB_26560356_Chip-Seq_TH2_Human1.73943087
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73405303
24GATA1_22025678_ChIP-Seq_K562_Human1.69433934
25VDR_24787735_ChIP-Seq_THP-1_Human1.67128054
26SPI1_23127762_ChIP-Seq_K562_Human1.61097515
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.59241028
28SPI1_23547873_ChIP-Seq_NB4_Human1.56045275
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52845058
30* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51784632
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50832375
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43589586
33GATA3_26560356_Chip-Seq_TH2_Human1.42591426
34VDR_24763502_ChIP-Seq_THP-1_Human1.42255763
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42010279
36MAF_26560356_Chip-Seq_TH1_Human1.40985993
37MYB_26560356_Chip-Seq_TH1_Human1.40057263
38GATA3_27048872_Chip-Seq_THYMUS_Human1.38567443
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38449900
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37168060
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.35652958
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32033972
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28598409
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28319567
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.27582533
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27082951
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25703352
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16441423
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.16304842
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15223914
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14911750
52UTX_26944678_Chip-Seq_JUKART_Human1.11283487
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10522508
54SCL_19346495_ChIP-Seq_HPC-7_Human1.10447579
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08699229
56STAT1_20625510_ChIP-Seq_HELA_Human1.07499313
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06298814
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05110956
59MAF_26560356_Chip-Seq_TH2_Human1.04565004
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03650125
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.01974871
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01256739
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01110629
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00571136
65PU_27001747_Chip-Seq_BMDM_Mouse0.99100066
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97781920
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97505161
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97485904
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96988912
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96404899
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93109158
72SOX2_20726797_ChIP-Seq_SW620_Human0.91839662
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91616281
74BCL6_27268052_Chip-Seq_Bcells_Human0.89405548
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87885545
76GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86949855
77EGR1_19374776_ChIP-ChIP_THP-1_Human0.86944464
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84875406
79GATA1_19941826_ChIP-Seq_K562_Human0.84692326
80VDR_21846776_ChIP-Seq_THP-1_Human0.84681851
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82677108
82ESR2_21235772_ChIP-Seq_MCF-7_Human0.82243508
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.81279081
84TRIM28_21343339_ChIP-Seq_HEK293_Human0.81128195
85BCOR_27268052_Chip-Seq_Bcells_Human0.78771481
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77693069
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74831160
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73720545
89LXR_22292898_ChIP-Seq_THP-1_Human0.72882004
90P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72868710
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72824114
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.72541294
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.72091169
94SMRT_27268052_Chip-Seq_Bcells_Human0.71172951
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70786063
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70431496
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69094314
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68726779
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.68132872
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67165537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.31122283
2MP0003303_peritoneal_inflammation3.64655163
3MP0009785_altered_susceptibility_to3.60090292
4MP0001835_abnormal_antigen_presentation3.59931277
5MP0006082_CNS_inflammation3.47576675
6MP0005671_abnormal_response_to3.27867430
7MP0003436_decreased_susceptibility_to3.27808683
8MP0002148_abnormal_hypersensitivity_rea3.12300419
9MP0005387_immune_system_phenotype2.91295035
10MP0001790_abnormal_immune_system2.91295035
11MP0005000_abnormal_immune_tolerance2.77733468
12MP0005025_abnormal_response_to2.70541555
13MP0000685_abnormal_immune_system2.65515738
14MP0002419_abnormal_innate_immunity2.46291789
15MP0001800_abnormal_humoral_immune2.45516202
16MP0002723_abnormal_immune_serum2.34556195
17MP0002452_abnormal_antigen_presenting2.20713292
18MP0003300_gastrointestinal_ulcer2.13552969
19MP0002139_abnormal_hepatobiliary_system2.13242349
20MP0001533_abnormal_skeleton_physiology2.11102659
21MP0004510_myositis2.05365491
22MP0002420_abnormal_adaptive_immunity1.98438992
23MP0001819_abnormal_immune_cell1.98344884
24MP0003195_calcinosis1.93564272
25MP0001845_abnormal_inflammatory_respons1.90159251
26MP0010155_abnormal_intestine_physiology1.88433907
27MP0003075_altered_response_to1.87251905
28MP0009764_decreased_sensitivity_to1.83226569
29MP0004947_skin_inflammation1.82563638
30MP0005058_abnormal_lysosome_morphology1.80223961
31MP0009333_abnormal_splenocyte_physiolog1.74842167
32MP0003172_abnormal_lysosome_physiology1.74419281
33MP0008469_abnormal_protein_level1.73922280
34MP0002405_respiratory_system_inflammati1.70814368
35MP0002138_abnormal_hepatobiliary_system1.68890222
36MP0009840_abnormal_foam_cell1.66404914
37MP0003806_abnormal_nucleotide_metabolis1.65040784
38MP0003763_abnormal_thymus_physiology1.54264520
39MP0005310_abnormal_salivary_gland1.48526559
40MP0006054_spinal_hemorrhage1.48385535
41MP0003191_abnormal_cellular_cholesterol1.45934607
42MP0000716_abnormal_immune_system1.43461247
43MP0001853_heart_inflammation1.37696370
44MP0005166_decreased_susceptibility_to1.36886480
45MP0000343_altered_response_to1.35845496
46MP0000604_amyloidosis1.34291306
47MP0005451_abnormal_body_composition1.29788651
48MP0003866_abnormal_defecation1.29484689
49MP0003448_altered_tumor_morphology1.27731186
50MP0005464_abnormal_platelet_physiology1.23924015
51MP0003690_abnormal_glial_cell1.23396978
52MP0002398_abnormal_bone_marrow1.23358490
53MP0005164_abnormal_response_to1.21962776
54MP0003183_abnormal_peptide_metabolism1.20165576
55MP0005167_abnormal_blood-brain_barrier1.13478666
56MP0002998_abnormal_bone_remodeling1.12650420
57MP0002254_reproductive_system_inflammat1.11384644
58MP0004883_abnormal_blood_vessel1.10144404
59MP0000689_abnormal_spleen_morphology1.09069692
60MP0000858_altered_metastatic_potential1.08426265
61MP0009763_increased_sensitivity_to1.07981843
62MP0003045_fibrosis1.07756533
63MP0002933_joint_inflammation1.06071287
64MP0002429_abnormal_blood_cell1.05392361
65MP0002277_abnormal_respiratory_mucosa1.02347554
66MP0002332_abnormal_exercise_endurance1.02042670
67MP0005390_skeleton_phenotype0.98564542
68MP0002722_abnormal_immune_system0.98556502
69MP0001501_abnormal_sleep_pattern0.96131278
70MP0002166_altered_tumor_susceptibility0.95730972
71MP0001542_abnormal_bone_strength0.92461839
72MP0005365_abnormal_bile_salt0.90181038
73MP0005360_urolithiasis0.88953679
74MP0002693_abnormal_pancreas_physiology0.87137761
75MP0001873_stomach_inflammation0.82877884
76MP0003656_abnormal_erythrocyte_physiolo0.79991351
77MP0009765_abnormal_xenobiotic_induced0.78791691
78MP0005319_abnormal_enzyme/_coenzyme0.77334993
79MP0001545_abnormal_hematopoietic_system0.77059812
80MP0005397_hematopoietic_system_phenotyp0.77059812
81MP0000920_abnormal_myelination0.74374422
82MP0005165_increased_susceptibility_to0.73212867
83MP0001663_abnormal_digestive_system0.72986363
84MP0008004_abnormal_stomach_pH0.72563021
85MP0005023_abnormal_wound_healing0.72380642
86MP0003252_abnormal_bile_duct0.69533366
87MP0009643_abnormal_urine_homeostasis0.69528759
88MP0002006_tumorigenesis0.69494037
89MP0003453_abnormal_keratinocyte_physiol0.68296136
90MP0003795_abnormal_bone_structure0.67315484
91MP0008874_decreased_physiological_sensi0.66423742
92MP0008260_abnormal_autophagy0.65845868
93MP0002136_abnormal_kidney_physiology0.65693015
94MP0000249_abnormal_blood_vessel0.63977816
95MP0000609_abnormal_liver_physiology0.63340855
96MP0000703_abnormal_thymus_morphology0.62784913
97MP0003879_abnormal_hair_cell0.62368825
98MP0000465_gastrointestinal_hemorrhage0.62303440
99MP0005584_abnormal_enzyme/coenzyme_acti0.61295659
100MP0009278_abnormal_bone_marrow0.60753413

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.02620853
2Retrobulbar optic neuritis (HP:0100654)4.99802051
3Optic neuritis (HP:0100653)4.99802051
4Abnormality of liposaccharide metabolism (HP:0010968)4.91146095
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.91146095
6Abnormality of glycolipid metabolism (HP:0010969)4.91146095
7Myositis (HP:0100614)4.76912305
8Eczematoid dermatitis (HP:0000976)4.43420691
9Abnormality of macrophages (HP:0004311)4.42536749
10Recurrent bacterial skin infections (HP:0005406)4.23714916
11Stomatitis (HP:0010280)4.22874805
12Systemic lupus erythematosus (HP:0002725)4.01002085
13Recurrent abscess formation (HP:0002722)4.00543227
14Elevated erythrocyte sedimentation rate (HP:0003565)3.80336405
15Pulmonary infiltrates (HP:0002113)3.55023159
16Mediastinal lymphadenopathy (HP:0100721)3.45858885
17Recurrent gram-negative bacterial infections (HP:0005420)3.40128035
18Gastrointestinal infarctions (HP:0005244)3.38234820
19Vasculitis (HP:0002633)3.25642632
20Keratoconjunctivitis sicca (HP:0001097)3.25123383
21Abnormality of T cell number (HP:0011839)3.22210494
22Recurrent fungal infections (HP:0002841)3.20599402
23T lymphocytopenia (HP:0005403)3.17986759
24Hemoptysis (HP:0002105)3.16089675
25Recurrent skin infections (HP:0001581)3.11379989
26Keratoconjunctivitis (HP:0001096)3.10136289
27Dysostosis multiplex (HP:0000943)3.05381628
28Autoimmune hemolytic anemia (HP:0001890)3.02415204
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.01110390
30Vacuolated lymphocytes (HP:0001922)2.98319075
31Meningitis (HP:0001287)2.93639401
32Increased IgM level (HP:0003496)2.93028878
33Obstructive lung disease (HP:0006536)2.89036043
34Chronic obstructive pulmonary disease (HP:0006510)2.89036043
35Hematochezia (HP:0002573)2.87482720
36Autoimmune thrombocytopenia (HP:0001973)2.82397595
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74886725
38Abnormality of polysaccharide metabolism (HP:0011012)2.74886725
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74886725
40Gangrene (HP:0100758)2.74630638
41Loss of speech (HP:0002371)2.72236867
42Encephalitis (HP:0002383)2.71088495
43Arterial thrombosis (HP:0004420)2.69014116
44Pulmonary embolism (HP:0002204)2.61753744
45Glomerulonephritis (HP:0000099)2.61015052
46Recurrent cutaneous fungal infections (HP:0011370)2.60493879
47Chronic mucocutaneous candidiasis (HP:0002728)2.60493879
48Mucopolysacchariduria (HP:0008155)2.59462680
49Urinary glycosaminoglycan excretion (HP:0003541)2.59462680
50Joint swelling (HP:0001386)2.55403725
51Abnormality of the pleura (HP:0002103)2.54041493
52Hypergammaglobulinemia (HP:0010702)2.44249308
53Purpura (HP:0000979)2.42525454
54Recurrent viral infections (HP:0004429)2.40839213
55Anorexia (HP:0002039)2.39825951
56Episodic fever (HP:0001954)2.38544198
57Abnormality of the pericardium (HP:0001697)2.38314853
58Abnormality of T cells (HP:0002843)2.36413354
59Leukocytosis (HP:0001974)2.34914003
60Pustule (HP:0200039)2.32542916
61Progressive neurologic deterioration (HP:0002344)2.31719069
62Gingivitis (HP:0000230)2.31325206
63Complement deficiency (HP:0004431)2.29189493
64Chest pain (HP:0100749)2.28747155
65Recurrent bronchitis (HP:0002837)2.27011580
66Increased cerebral lipofuscin (HP:0011813)2.25747382
67Increased serum ferritin (HP:0003281)2.24594708
68Interstitial pulmonary disease (HP:0006530)2.23670409
69Gingival bleeding (HP:0000225)2.22268814
70Petechiae (HP:0000967)2.22153036
71Increased IgE level (HP:0003212)2.18876366
72Acne (HP:0001061)2.17735898
73Urticaria (HP:0001025)2.16907433
74Disinhibition (HP:0000734)2.16380550
75Eosinophilia (HP:0001880)2.14924316
76Amyloidosis (HP:0011034)2.09870718
77Abnormality of iron homeostasis (HP:0011031)2.09349583
78Peritonitis (HP:0002586)2.08724901
79Polyneuropathy (HP:0001271)2.08715437
80IgG deficiency (HP:0004315)2.06502172
81Malnutrition (HP:0004395)2.06017911
82Chronic diarrhea (HP:0002028)2.02013621
83Keratitis (HP:0000491)1.99856503
84Mutism (HP:0002300)1.99344002
85Glomerulopathy (HP:0100820)1.97576655
86Vertigo (HP:0002321)1.97429096
87Basal ganglia calcification (HP:0002135)1.97311704
88Granulocytopenia (HP:0001913)1.91317234
89Abnormality of complement system (HP:0005339)1.89421365
90Nuclear cataract (HP:0100018)1.89359062
91Increased CSF protein (HP:0002922)1.88836911
92Arthralgia (HP:0002829)1.86979003
93Chronic otitis media (HP:0000389)1.86866074
94Abnormality of T cell physiology (HP:0011840)1.85653063
95Abnormality of transition element cation homeostasis (HP:0011030)1.85587161
96Thyroiditis (HP:0100646)1.84793575
97Abnormality of eosinophils (HP:0001879)1.84038272
98Parakeratosis (HP:0001036)1.83531905
99Abnormality of the endocardium (HP:0004306)1.82605850
100Increased neuronal autofluorescent lipopigment (HP:0002074)1.82183814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.74325577
2TYK23.55121534
3RIPK43.13341171
4MAP4K12.89490368
5TBK12.68148779
6IKBKE2.58386046
7MAP3K142.49006864
8ERN12.46051386
9GRK72.39062771
10IRAK42.36881208
11BLK2.31078530
12IRAK32.27827459
13JAK12.20803885
14JAK32.19127784
15CSK2.10882109
16IKBKB2.02366278
17MAP3K31.92097139
18FRK1.84433490
19TAOK31.69254593
20ZAP701.67174352
21RIPK11.65632514
22ADRBK21.59478948
23BMPR21.58517992
24TNK21.54956249
25MATK1.53626204
26FES1.53495412
27SYK1.52302257
28FGFR31.50503088
29FGFR41.44647254
30KIT1.41704975
31FGR1.34544768
32MAP2K31.33219272
33MAP3K111.30590147
34TGFBR21.30174558
35JAK21.28059998
36LYN1.25812054
37TAOK21.20836572
38LCK1.20608790
39MAP3K131.19913100
40EPHB11.17317602
41ITK1.12252991
42TAOK11.12177059
43MAP3K11.11095679
44GRK61.09520125
45DDR21.07166859
46DAPK21.06020213
47HCK1.06014838
48CDC42BPA1.05938802
49BTK0.97510601
50IRAK10.95691430
51HIPK20.93837595
52NME20.93614417
53CSF1R0.93115760
54EPHA30.91067428
55MAP2K60.84832015
56STK100.78236726
57CHUK0.76881847
58MOS0.75610212
59PRPF4B0.71330051
60PDK10.70764265
61NLK0.70118633
62MAPKAPK30.69369967
63PRKD20.69351096
64PIM20.68571765
65MARK30.64499203
66PRKCQ0.63976693
67GRK50.63034348
68PTK2B0.61091175
69ABL20.57941649
70TLK10.56184994
71CAMKK20.56134066
72IRAK20.53259218
73MST40.50075450
74PDPK10.49789684
75TEC0.48758250
76MAPK110.47406094
77FYN0.46294841
78PIM10.45629314
79MAP3K50.42772960
80ACVR1B0.42751490
81MAPK70.42347735
82TESK20.41778293
83TRPM70.40481473
84ABL10.39140796
85MAPKAPK20.37089142
86KDR0.36925957
87SIK30.36516381
88MAP3K20.35794678
89PRKCD0.34990768
90FER0.31614596
91MAP3K120.31091921
92INSR0.30294281
93PRKAA20.29618246
94IGF1R0.29577827
95EGFR0.28968833
96STK240.28915794
97GRK10.28646712
98FGFR20.27823849
99PTK60.27815755
100PRKCH0.27741382

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.31645028
2Graft-versus-host disease_Homo sapiens_hsa053323.01046213
3Autoimmune thyroid disease_Homo sapiens_hsa053202.92737750
4Staphylococcus aureus infection_Homo sapiens_hsa051502.92662334
5Type I diabetes mellitus_Homo sapiens_hsa049402.70739763
6Leishmaniasis_Homo sapiens_hsa051402.48838072
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.47551211
8Asthma_Homo sapiens_hsa053102.44496496
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.39982476
10Osteoclast differentiation_Homo sapiens_hsa043802.38233557
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.31174919
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29964682
13Rheumatoid arthritis_Homo sapiens_hsa053232.28347908
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14830342
15Primary immunodeficiency_Homo sapiens_hsa053402.14335217
16African trypanosomiasis_Homo sapiens_hsa051432.07404965
17Other glycan degradation_Homo sapiens_hsa005112.04152000
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04019150
19Antigen processing and presentation_Homo sapiens_hsa046121.95749297
20Malaria_Homo sapiens_hsa051441.89678370
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89162595
22Tuberculosis_Homo sapiens_hsa051521.77045767
23Measles_Homo sapiens_hsa051621.76886165
24Pertussis_Homo sapiens_hsa051331.73712964
25TNF signaling pathway_Homo sapiens_hsa046681.70797970
26Influenza A_Homo sapiens_hsa051641.64359957
27Hematopoietic cell lineage_Homo sapiens_hsa046401.57905891
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56073241
29Legionellosis_Homo sapiens_hsa051341.54804934
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53610229
31Lysosome_Homo sapiens_hsa041421.50493679
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.47124390
33Herpes simplex infection_Homo sapiens_hsa051681.42849329
34Toxoplasmosis_Homo sapiens_hsa051451.39345001
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37315584
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.34954460
37Viral myocarditis_Homo sapiens_hsa054161.29283738
38Hepatitis C_Homo sapiens_hsa051601.20668335
39Chemokine signaling pathway_Homo sapiens_hsa040621.18462686
40Complement and coagulation cascades_Homo sapiens_hsa046101.16075479
41T cell receptor signaling pathway_Homo sapiens_hsa046601.12249340
42Phagosome_Homo sapiens_hsa041451.10628280
43B cell receptor signaling pathway_Homo sapiens_hsa046621.07077230
44Salmonella infection_Homo sapiens_hsa051321.05442341
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95393031
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90773130
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90660064
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88823745
49Sulfur metabolism_Homo sapiens_hsa009200.85719513
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85159181
51Collecting duct acid secretion_Homo sapiens_hsa049660.78062782
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.76480332
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74649190
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.73692809
55Hepatitis B_Homo sapiens_hsa051610.70891614
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68817691
57Shigellosis_Homo sapiens_hsa051310.68489965
58Prion diseases_Homo sapiens_hsa050200.67555664
59Apoptosis_Homo sapiens_hsa042100.66034094
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54612892
61Type II diabetes mellitus_Homo sapiens_hsa049300.51937790
62Prolactin signaling pathway_Homo sapiens_hsa049170.50149811
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.49871862
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48200060
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47376531
66Mineral absorption_Homo sapiens_hsa049780.46816009
67Sphingolipid metabolism_Homo sapiens_hsa006000.45157362
68Tryptophan metabolism_Homo sapiens_hsa003800.42431830
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41961201
70Epstein-Barr virus infection_Homo sapiens_hsa051690.41895705
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.41797828
72Amoebiasis_Homo sapiens_hsa051460.41335559
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37790535
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37085234
75Acute myeloid leukemia_Homo sapiens_hsa052210.36249327
76Arachidonic acid metabolism_Homo sapiens_hsa005900.35460218
77Insulin resistance_Homo sapiens_hsa049310.35233228
78PPAR signaling pathway_Homo sapiens_hsa033200.34693168
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34028933
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31102162
81Endocytosis_Homo sapiens_hsa041440.30358883
82Galactose metabolism_Homo sapiens_hsa000520.29121768
83ABC transporters_Homo sapiens_hsa020100.27105250
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.25248448
85VEGF signaling pathway_Homo sapiens_hsa043700.25082349
86Dorso-ventral axis formation_Homo sapiens_hsa043200.21894956
87Regulation of autophagy_Homo sapiens_hsa041400.21451173
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.20994708
89Vibrio cholerae infection_Homo sapiens_hsa051100.20400180
90Platelet activation_Homo sapiens_hsa046110.18266326
91Chemical carcinogenesis_Homo sapiens_hsa052040.17450852
92Ether lipid metabolism_Homo sapiens_hsa005650.17273786
93Peroxisome_Homo sapiens_hsa041460.15213281
94Caffeine metabolism_Homo sapiens_hsa002320.14957552
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13818519
96HTLV-I infection_Homo sapiens_hsa051660.12684967
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12075840
98HIF-1 signaling pathway_Homo sapiens_hsa040660.11816455
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11296984
100FoxO signaling pathway_Homo sapiens_hsa040680.10649058

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