APOL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.44223681
2negative regulation of cell killing (GO:0031342)5.27752391
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.27752391
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14091901
5antigen processing and presentation of endogenous antigen (GO:0019883)4.95613505
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.87878276
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79485941
8regulation of T cell tolerance induction (GO:0002664)4.59824163
9regulation of dendritic cell antigen processing and presentation (GO:0002604)4.44480419
10type I interferon signaling pathway (GO:0060337)4.42270916
11cellular response to type I interferon (GO:0071357)4.42270916
12response to type I interferon (GO:0034340)4.38968300
13negative regulation of interleukin-12 production (GO:0032695)4.25857218
14immunoglobulin mediated immune response (GO:0016064)4.13083833
15regulation of T-helper 1 cell differentiation (GO:0045625)4.11632884
16regulation of tolerance induction (GO:0002643)4.08996738
17interferon-gamma-mediated signaling pathway (GO:0060333)4.04651881
18regulation of gamma-delta T cell activation (GO:0046643)4.00738142
19detection of other organism (GO:0098543)3.97781075
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96496945
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.96496945
22modulation by symbiont of host immune response (GO:0052553)3.96496945
23positive regulation by symbiont of host defense response (GO:0052509)3.96496945
24modulation by symbiont of host defense response (GO:0052031)3.96496945
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96496945
26positive regulation of type 2 immune response (GO:0002830)3.96479101
27positive regulation of tolerance induction (GO:0002645)3.95657125
28T cell migration (GO:0072678)3.90917793
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.89000850
30detection of bacterium (GO:0016045)3.82374869
31regulation of antigen processing and presentation (GO:0002577)3.73486750
32macrophage activation involved in immune response (GO:0002281)3.72947569
33regulation of B cell receptor signaling pathway (GO:0050855)3.71774460
34positive regulation of antigen processing and presentation (GO:0002579)3.68727680
35response to peptidoglycan (GO:0032494)3.63565268
36production of molecular mediator involved in inflammatory response (GO:0002532)3.60049962
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57685798
38neutrophil activation involved in immune response (GO:0002283)3.50817973
39NIK/NF-kappaB signaling (GO:0038061)3.42961816
40regulation of interferon-beta biosynthetic process (GO:0045357)3.36794222
41regulation of gamma-delta T cell differentiation (GO:0045586)3.34385931
42regulation of regulatory T cell differentiation (GO:0045589)3.33758578
43positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.32062001
44negative regulation of T cell mediated immunity (GO:0002710)3.31844696
45detection of external biotic stimulus (GO:0098581)3.29468645
46T-helper 1 type immune response (GO:0042088)3.25127643
47negative thymic T cell selection (GO:0045060)3.23617825
48B cell mediated immunity (GO:0019724)3.22723038
49negative T cell selection (GO:0043383)3.21484058
50lymphocyte chemotaxis (GO:0048247)3.19187524
51regulation of type 2 immune response (GO:0002828)3.14724615
52negative regulation of innate immune response (GO:0045824)3.14574343
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.14550444
54regulation of interferon-alpha production (GO:0032647)3.14285225
55defense response to protozoan (GO:0042832)3.14231247
56regulation of alpha-beta T cell proliferation (GO:0046640)3.13386270
57cellular response to interferon-gamma (GO:0071346)3.13169329
58myeloid dendritic cell differentiation (GO:0043011)3.11746966
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11113283
60positive thymic T cell selection (GO:0045059)3.10231890
61detection of molecule of bacterial origin (GO:0032490)3.09092752
62regulation of interleukin-12 production (GO:0032655)3.08234484
63positive regulation of interferon-alpha production (GO:0032727)3.07933685
64regulation of chronic inflammatory response (GO:0002676)3.06779951
65regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.04777997
66response to interferon-gamma (GO:0034341)3.01010238
67positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.99801738
68regulation of T cell mediated cytotoxicity (GO:0001914)2.96867325
69negative regulation of leukocyte mediated immunity (GO:0002704)2.96439229
70dendritic cell chemotaxis (GO:0002407)2.96072047
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94239459
72leukocyte aggregation (GO:0070486)2.92529968
73myeloid dendritic cell activation (GO:0001773)2.91860689
74response to interferon-beta (GO:0035456)2.91166655
75detection of biotic stimulus (GO:0009595)2.89020463
76regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.88557700
77germinal center formation (GO:0002467)2.88301325
78response to protozoan (GO:0001562)2.87385319
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87192790
80response to muramyl dipeptide (GO:0032495)2.85149250
81antigen processing and presentation via MHC class Ib (GO:0002475)2.83564790
82negative regulation of viral genome replication (GO:0045071)2.82178132
83negative regulation of cytokine production involved in immune response (GO:0002719)2.81553543
84response to interleukin-15 (GO:0070672)2.79553226
85response to host immune response (GO:0052572)2.79205684
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79205684
87T cell selection (GO:0045058)2.77960687
88positive regulation of interleukin-12 production (GO:0032735)2.77352915
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77137920
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.76591810
91microglial cell activation (GO:0001774)2.75223080
92myeloid cell activation involved in immune response (GO:0002275)2.75179828
93regulation of interleukin-2 biosynthetic process (GO:0045076)2.74277172
94positive regulation of T-helper cell differentiation (GO:0045624)2.73960043
95regulation of natural killer cell mediated immunity (GO:0002715)2.73890648
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73890648
97regulation of T-helper cell differentiation (GO:0045622)2.72790094
98positive T cell selection (GO:0043368)2.72078851
99interferon-gamma secretion (GO:0072643)2.70977224
100regulation of interleukin-1 beta secretion (GO:0050706)2.70307431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.07439631
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.05272439
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.02350507
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.36948557
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.20265629
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94839806
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53124320
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.16664155
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99973754
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.93740287
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.84169838
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74452184
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73057124
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71564400
15RUNX_20019798_ChIP-Seq_JUKART_Human2.60725738
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37998729
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32731513
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31588715
19MYB_26560356_Chip-Seq_TH2_Human2.23710246
20MAF_26560356_Chip-Seq_TH1_Human2.10031037
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07040764
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97581180
23VDR_24763502_ChIP-Seq_THP-1_Human1.97147221
24SPI1_23547873_ChIP-Seq_NB4_Human1.95566962
25GATA1_22025678_ChIP-Seq_K562_Human1.90093013
26SPI1_23127762_ChIP-Seq_K562_Human1.89761617
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87126981
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86910474
29VDR_21846776_ChIP-Seq_THP-1_Human1.86663595
30* MYB_26560356_Chip-Seq_TH1_Human1.85390030
31SCL_19346495_ChIP-Seq_HPC-7_Human1.79476664
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78611100
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.76843650
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74784197
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.74770808
36* UTX_26944678_Chip-Seq_JUKART_Human1.69901547
37* SMAD_19615063_ChIP-ChIP_OVARY_Human1.63740456
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60531652
39MYC_22102868_ChIP-Seq_BL_Human1.57297505
40VDR_24787735_ChIP-Seq_THP-1_Human1.56445593
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.52091687
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50200324
43MAF_26560356_Chip-Seq_TH2_Human1.49765252
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46310055
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44907991
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43664904
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42188979
48TCF7_22412390_ChIP-Seq_EML_Mouse1.41591853
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.35945753
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33818798
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31003197
52GATA3_26560356_Chip-Seq_TH2_Human1.29821572
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29314425
54KDM2B_26808549_Chip-Seq_DND41_Human1.28907255
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28429600
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26021051
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23498087
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23003721
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22949506
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.22751749
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21666054
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21638170
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20244961
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.18664493
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18460348
66GATA1_19941826_ChIP-Seq_K562_Human1.18459401
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16832177
68PU_27001747_Chip-Seq_BMDM_Mouse1.16036164
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12954555
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12937310
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12583762
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12048538
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11048587
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10997331
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10634234
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10129969
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09345376
78LXR_22292898_ChIP-Seq_THP-1_Human1.09225085
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09104811
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08878472
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05998693
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04874495
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00382719
84BCL6_27268052_Chip-Seq_Bcells_Human0.97896239
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95319103
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94766646
87LXR_22158963_ChIP-Seq_LIVER_Mouse0.93941827
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93476824
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92376910
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88997553
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87132396
92BCOR_27268052_Chip-Seq_Bcells_Human0.86306622
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85899909
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84391960
95EGR1_19032775_ChIP-ChIP_M12_Human0.84251085
96ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81681419
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81450581
98GATA2_19941826_ChIP-Seq_K562_Human0.78918463
99* STAT1_20625510_ChIP-Seq_HELA_Human0.78881020
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78174067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.22375411
2MP0001835_abnormal_antigen_presentation4.18241670
3MP0003303_peritoneal_inflammation3.80110469
4MP0003436_decreased_susceptibility_to3.42088282
5MP0005671_abnormal_response_to3.32863765
6MP0009785_altered_susceptibility_to3.30262059
7MP0000685_abnormal_immune_system3.13131594
8MP0006082_CNS_inflammation3.06211804
9MP0005387_immune_system_phenotype3.06113716
10MP0001790_abnormal_immune_system3.06113716
11MP0002148_abnormal_hypersensitivity_rea2.99421136
12MP0005000_abnormal_immune_tolerance2.96188356
13MP0001800_abnormal_humoral_immune2.89877877
14MP0005025_abnormal_response_to2.82611930
15MP0002419_abnormal_innate_immunity2.61331658
16MP0002723_abnormal_immune_serum2.54648327
17MP0002452_abnormal_antigen_presenting2.49066592
18MP0003300_gastrointestinal_ulcer2.31934818
19MP0001819_abnormal_immune_cell2.25238134
20MP0002420_abnormal_adaptive_immunity2.24902326
21MP0003763_abnormal_thymus_physiology2.22071329
22MP0010155_abnormal_intestine_physiology2.15171001
23MP0001533_abnormal_skeleton_physiology1.95441712
24MP0001845_abnormal_inflammatory_respons1.88570731
25MP0002405_respiratory_system_inflammati1.88535641
26MP0004947_skin_inflammation1.85127750
27MP0009333_abnormal_splenocyte_physiolog1.84528824
28MP0009764_decreased_sensitivity_to1.78414882
29MP0004510_myositis1.76800521
30MP0003191_abnormal_cellular_cholesterol1.75867321
31MP0002139_abnormal_hepatobiliary_system1.73188659
32MP0000716_abnormal_immune_system1.71561112
33MP0005451_abnormal_body_composition1.70480732
34MP0008469_abnormal_protein_level1.66327992
35MP0002398_abnormal_bone_marrow1.65109115
36MP0002138_abnormal_hepatobiliary_system1.64699555
37MP0005464_abnormal_platelet_physiology1.60528438
38MP0002166_altered_tumor_susceptibility1.58553147
39MP0005058_abnormal_lysosome_morphology1.53718018
40MP0009840_abnormal_foam_cell1.49537412
41MP0003075_altered_response_to1.48429227
42MP0005310_abnormal_salivary_gland1.38329271
43MP0000689_abnormal_spleen_morphology1.37547767
44MP0000343_altered_response_to1.35341806
45MP0003806_abnormal_nucleotide_metabolis1.35281956
46MP0002429_abnormal_blood_cell1.33953493
47MP0002722_abnormal_immune_system1.32851476
48MP0003172_abnormal_lysosome_physiology1.29656567
49MP0003866_abnormal_defecation1.28759922
50MP0009278_abnormal_bone_marrow1.28312600
51MP0008260_abnormal_autophagy1.27536676
52MP0003448_altered_tumor_morphology1.26773402
53MP0001853_heart_inflammation1.26654114
54MP0000465_gastrointestinal_hemorrhage1.26449107
55MP0000604_amyloidosis1.26226342
56MP0000858_altered_metastatic_potential1.25324727
57MP0002998_abnormal_bone_remodeling1.22631711
58MP0005166_decreased_susceptibility_to1.22241556
59MP0001873_stomach_inflammation1.22084670
60MP0001545_abnormal_hematopoietic_system1.20087938
61MP0005397_hematopoietic_system_phenotyp1.20087938
62MP0003828_pulmonary_edema1.15206601
63MP0002933_joint_inflammation1.14527399
64MP0003690_abnormal_glial_cell1.13512102
65MP0002006_tumorigenesis1.08202514
66MP0009763_increased_sensitivity_to1.06158649
67MP0000703_abnormal_thymus_morphology1.05880923
68MP0004883_abnormal_blood_vessel0.98687942
69MP0005164_abnormal_response_to0.98438244
70MP0003183_abnormal_peptide_metabolism0.97612551
71MP0002332_abnormal_exercise_endurance0.93888778
72MP0003656_abnormal_erythrocyte_physiolo0.93409493
73MP0001851_eye_inflammation0.91010285
74MP0008004_abnormal_stomach_pH0.85708946
75MP0001663_abnormal_digestive_system0.85142366
76MP0000249_abnormal_blood_vessel0.84687365
77MP0003195_calcinosis0.84682245
78MP0002254_reproductive_system_inflammat0.81888961
79MP0002132_abnormal_respiratory_system0.81678243
80MP0005167_abnormal_blood-brain_barrier0.81363330
81MP0005365_abnormal_bile_salt0.78914130
82MP0009765_abnormal_xenobiotic_induced0.78883560
83MP0005360_urolithiasis0.78096599
84MP0002277_abnormal_respiratory_mucosa0.77748087
85MP0005390_skeleton_phenotype0.74911628
86MP0003646_muscle_fatigue0.71391552
87MP0006054_spinal_hemorrhage0.71147982
88MP0003453_abnormal_keratinocyte_physiol0.70002982
89MP0000609_abnormal_liver_physiology0.69982126
90MP0003045_fibrosis0.69124903
91MP0008874_decreased_physiological_sensi0.68304964
92MP0003091_abnormal_cell_migration0.67547526
93MP0005319_abnormal_enzyme/_coenzyme0.64728060
94MP0004808_abnormal_hematopoietic_stem0.63140050
95MP0004130_abnormal_muscle_cell0.59999122
96MP0005535_abnormal_body_temperature0.59921888
97MP0003795_abnormal_bone_structure0.59397623
98MP0005584_abnormal_enzyme/coenzyme_acti0.59218202
99MP0003252_abnormal_bile_duct0.57430696
100MP0009115_abnormal_fat_cell0.53382403

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.31222997
2Myositis (HP:0100614)5.00057941
3Orchitis (HP:0100796)4.91786842
4Retrobulbar optic neuritis (HP:0100654)4.84696625
5Optic neuritis (HP:0100653)4.84696625
6Recurrent bacterial skin infections (HP:0005406)4.79824945
7Recurrent abscess formation (HP:0002722)4.62868643
8Abnormality of macrophages (HP:0004311)4.38609651
9Elevated erythrocyte sedimentation rate (HP:0003565)4.25070638
10Gastrointestinal infarctions (HP:0005244)4.23270334
11Systemic lupus erythematosus (HP:0002725)4.14092059
12Stomatitis (HP:0010280)3.97801062
13Recurrent gram-negative bacterial infections (HP:0005420)3.90691798
14Recurrent fungal infections (HP:0002841)3.79250590
15Mediastinal lymphadenopathy (HP:0100721)3.76603830
16T lymphocytopenia (HP:0005403)3.63174991
17Vasculitis (HP:0002633)3.63062472
18Keratoconjunctivitis sicca (HP:0001097)3.55585890
19Meningitis (HP:0001287)3.55252832
20Abnormality of T cell number (HP:0011839)3.52668704
21Recurrent skin infections (HP:0001581)3.40212631
22Recurrent viral infections (HP:0004429)3.39785307
23Pulmonary infiltrates (HP:0002113)3.39427440
24Hemoptysis (HP:0002105)3.36431501
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.33351995
26Chronic mucocutaneous candidiasis (HP:0002728)3.31697033
27Recurrent cutaneous fungal infections (HP:0011370)3.31697033
28Increased IgM level (HP:0003496)3.29306155
29Keratoconjunctivitis (HP:0001096)3.28459961
30Encephalitis (HP:0002383)3.21952460
31Increased IgE level (HP:0003212)3.09228041
32Chronic obstructive pulmonary disease (HP:0006510)3.07112268
33Obstructive lung disease (HP:0006536)3.07112268
34Abnormality of liposaccharide metabolism (HP:0010968)3.03673221
35Abnormality of glycosphingolipid metabolism (HP:0004343)3.03673221
36Abnormality of glycolipid metabolism (HP:0010969)3.03673221
37Gingivitis (HP:0000230)3.00731643
38Spontaneous hematomas (HP:0007420)2.98657694
39Autoimmune thrombocytopenia (HP:0001973)2.90019044
40Autoimmune hemolytic anemia (HP:0001890)2.85164617
41Recurrent bronchitis (HP:0002837)2.83916067
42Leukocytosis (HP:0001974)2.83523376
43Chest pain (HP:0100749)2.82832757
44Gangrene (HP:0100758)2.82408030
45Hypergammaglobulinemia (HP:0010702)2.75454110
46Colitis (HP:0002583)2.72565724
47Abnormality of T cells (HP:0002843)2.72441592
48Urticaria (HP:0001025)2.70670965
49Arterial thrombosis (HP:0004420)2.70458084
50Pulmonary embolism (HP:0002204)2.68916315
51Panhypogammaglobulinemia (HP:0003139)2.67257497
52Inflammation of the large intestine (HP:0002037)2.61826100
53Chronic otitis media (HP:0000389)2.61074919
54Amyloidosis (HP:0011034)2.56459413
55Complement deficiency (HP:0004431)2.54147943
56Pustule (HP:0200039)2.50405843
57Cellulitis (HP:0100658)2.50104886
58Gastrointestinal inflammation (HP:0004386)2.49315496
59Hematochezia (HP:0002573)2.49290075
60Gingival bleeding (HP:0000225)2.48379172
61Agammaglobulinemia (HP:0004432)2.48155670
62Anorexia (HP:0002039)2.47844704
63Granulocytopenia (HP:0001913)2.46462937
64Glomerulonephritis (HP:0000099)2.44359890
65Eosinophilia (HP:0001880)2.43603297
66Purpura (HP:0000979)2.42848909
67Dysostosis multiplex (HP:0000943)2.39108125
68Abnormality of the pleura (HP:0002103)2.36978876
69Malnutrition (HP:0004395)2.34643331
70Abnormality of complement system (HP:0005339)2.33966770
71Epistaxis (HP:0000421)2.33527591
72Joint swelling (HP:0001386)2.32984883
73Prolonged bleeding time (HP:0003010)2.32768000
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30877761
75Loss of speech (HP:0002371)2.29446124
76Increased serum ferritin (HP:0003281)2.28449791
77Peritonitis (HP:0002586)2.25874381
78Gastrointestinal stroma tumor (HP:0100723)2.23571203
79Abnormality of B cell number (HP:0010975)2.22528528
80Interstitial pulmonary disease (HP:0006530)2.21286225
81Abnormality of the nasal mucosa (HP:0000433)2.18202236
82IgG deficiency (HP:0004315)2.17642023
83Lymphopenia (HP:0001888)2.17485966
84Abnormality of eosinophils (HP:0001879)2.14978198
85Premature loss of primary teeth (HP:0006323)2.14229493
86Increased cerebral lipofuscin (HP:0011813)2.13694691
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.11586868
88Abnormality of the endocardium (HP:0004306)2.09678519
89Polyneuropathy (HP:0001271)2.09065404
90Severe combined immunodeficiency (HP:0004430)2.08478604
91Glomerulopathy (HP:0100820)2.08377251
92Abnormality of T cell physiology (HP:0011840)2.07822266
93Osteomyelitis (HP:0002754)2.05883332
94Episodic fever (HP:0001954)2.05364642
95Nasal polyposis (HP:0100582)2.05297219
96Petechiae (HP:0000967)2.05242347
97Abnormality of iron homeostasis (HP:0011031)2.02599090
98Arthralgia (HP:0002829)2.00840683
99Abnormality of the pericardium (HP:0001697)1.98217867
100Abnormality of the peritoneum (HP:0002585)1.97367265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.81805650
2TYK23.74842014
3RIPK43.45415342
4IKBKE2.80492314
5MAP3K142.80089138
6TXK2.77034482
7JAK32.74061735
8PRPF4B2.66982086
9ERN12.62446242
10BLK2.42165028
11IRAK42.39034087
12TBK12.35903832
13CSK2.31071297
14JAK12.22725662
15FGFR42.15274962
16KIT2.01463317
17ZAP702.00403247
18FES1.98521425
19GRK71.82674471
20IRAK31.71023282
21MAP3K131.70987301
22SYK1.67085427
23IKBKB1.65767563
24MAP2K31.60938210
25MATK1.59034405
26FGR1.53606261
27BTK1.53219876
28RIPK11.51556461
29MAP3K111.47820049
30CDC42BPA1.43638393
31JAK21.36074003
32FGFR31.35851567
33LYN1.35557602
34TAOK31.31367669
35TNK21.29241376
36EPHB11.29144808
37LCK1.29056493
38HCK1.28148011
39MAP3K31.25687412
40GRK61.25672650
41TAOK21.24321988
42TGFBR21.22797707
43BMPR21.18548445
44ITK1.14076800
45CSF1R1.13385098
46SIK31.08411926
47TAOK11.07990241
48EPHA31.05208410
49MAP3K11.02405920
50MARK30.96482265
51TESK20.95962944
52TEC0.93807611
53IRAK10.82984237
54HIPK20.80200463
55DDR20.79945574
56CHUK0.74067212
57STK100.68062162
58MAPK70.67668154
59ADRBK20.67357020
60MAPK110.66290986
61NLK0.65843369
62CAMKK20.65675457
63NME20.63618189
64TRIB30.62996044
65PIM10.62896955
66PDK10.59170418
67KDR0.54702126
68PRKCQ0.51309333
69MAPK120.50576793
70MARK20.49343404
71PDPK10.48610258
72FYN0.47289350
73CDK40.45635996
74MAP3K50.45494444
75MOS0.45454245
76LRRK20.45301423
77PRKD20.43878702
78SIK10.43672740
79SIK20.41056975
80CDK60.37699367
81IRAK20.37096797
82MAPK40.36137456
83MAP2K60.35787277
84RPS6KL10.35407438
85RPS6KC10.35407438
86CAMKK10.35277574
87MAPKAPK20.35219672
88PIK3CG0.32835944
89MAP3K70.32625158
90ABL10.32398024
91CLK10.30975668
92YES10.30316224
93PIM20.30312750
94MAP3K60.30115859
95TTN0.28413071
96MAP2K20.28366691
97PTK60.28260428
98RPS6KA60.28121842
99EGFR0.27949051
100TYRO30.27340372

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.58204561
2Graft-versus-host disease_Homo sapiens_hsa053323.20213193
3Autoimmune thyroid disease_Homo sapiens_hsa053203.17711325
4Staphylococcus aureus infection_Homo sapiens_hsa051503.12524070
5Leishmaniasis_Homo sapiens_hsa051402.86635981
6Asthma_Homo sapiens_hsa053102.73302351
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.65998625
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.57442157
9Primary immunodeficiency_Homo sapiens_hsa053402.55635725
10Type I diabetes mellitus_Homo sapiens_hsa049402.53199812
11Osteoclast differentiation_Homo sapiens_hsa043802.52242747
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.46402283
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.27444491
14Antigen processing and presentation_Homo sapiens_hsa046122.14197525
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.08245056
16Viral myocarditis_Homo sapiens_hsa054161.89966153
17Tuberculosis_Homo sapiens_hsa051521.85794650
18Measles_Homo sapiens_hsa051621.84451890
19Influenza A_Homo sapiens_hsa051641.81007049
20Malaria_Homo sapiens_hsa051441.77260612
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75540045
22Toxoplasmosis_Homo sapiens_hsa051451.73839279
23B cell receptor signaling pathway_Homo sapiens_hsa046621.70872273
24Rheumatoid arthritis_Homo sapiens_hsa053231.70416192
25Hematopoietic cell lineage_Homo sapiens_hsa046401.64846673
26Herpes simplex infection_Homo sapiens_hsa051681.64220529
27African trypanosomiasis_Homo sapiens_hsa051431.63816793
28Pertussis_Homo sapiens_hsa051331.63488113
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60672712
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58282316
31TNF signaling pathway_Homo sapiens_hsa046681.57552665
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.45521066
33Other glycan degradation_Homo sapiens_hsa005111.44369310
34Chemokine signaling pathway_Homo sapiens_hsa040621.43095043
35T cell receptor signaling pathway_Homo sapiens_hsa046601.38994218
36Legionellosis_Homo sapiens_hsa051341.29010207
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28501299
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22056137
39Hepatitis C_Homo sapiens_hsa051601.21325159
40Acute myeloid leukemia_Homo sapiens_hsa052211.13328501
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12789241
42Complement and coagulation cascades_Homo sapiens_hsa046101.05464089
43Phagosome_Homo sapiens_hsa041451.03697454
44Hepatitis B_Homo sapiens_hsa051611.00607393
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99790293
46Lysosome_Homo sapiens_hsa041420.98257052
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89177751
48Apoptosis_Homo sapiens_hsa042100.87796474
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.81764421
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.81547019
51Salmonella infection_Homo sapiens_hsa051320.76374819
52Prolactin signaling pathway_Homo sapiens_hsa049170.74256940
53Shigellosis_Homo sapiens_hsa051310.74039924
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73057220
55Epstein-Barr virus infection_Homo sapiens_hsa051690.67664477
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62726277
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.62318562
58Platelet activation_Homo sapiens_hsa046110.58776271
59Pancreatic cancer_Homo sapiens_hsa052120.55405766
60HTLV-I infection_Homo sapiens_hsa051660.52957949
61Prion diseases_Homo sapiens_hsa050200.50441548
62VEGF signaling pathway_Homo sapiens_hsa043700.47787226
63Caffeine metabolism_Homo sapiens_hsa002320.47302335
64Amoebiasis_Homo sapiens_hsa051460.47274784
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46185710
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45462789
67Tryptophan metabolism_Homo sapiens_hsa003800.45208947
68Non-small cell lung cancer_Homo sapiens_hsa052230.42853771
69Systemic lupus erythematosus_Homo sapiens_hsa053220.41551171
70Chronic myeloid leukemia_Homo sapiens_hsa052200.40846497
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40663547
72Insulin resistance_Homo sapiens_hsa049310.40481289
73Viral carcinogenesis_Homo sapiens_hsa052030.36879739
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.36471651
75PPAR signaling pathway_Homo sapiens_hsa033200.35957897
76Arachidonic acid metabolism_Homo sapiens_hsa005900.32783008
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.32617223
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.30231218
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30042259
80Endocytosis_Homo sapiens_hsa041440.29358521
81FoxO signaling pathway_Homo sapiens_hsa040680.28518211
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.28491526
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26017482
84Notch signaling pathway_Homo sapiens_hsa043300.24924691
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24586955
86Dorso-ventral axis formation_Homo sapiens_hsa043200.24190345
87Renal cell carcinoma_Homo sapiens_hsa052110.22906942
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19677698
89HIF-1 signaling pathway_Homo sapiens_hsa040660.19532274
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19163937
91ABC transporters_Homo sapiens_hsa020100.18843199
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17696398
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.17236768
94Type II diabetes mellitus_Homo sapiens_hsa049300.15930463
95Sulfur metabolism_Homo sapiens_hsa009200.15847162
96Linoleic acid metabolism_Homo sapiens_hsa005910.15829079
97Bladder cancer_Homo sapiens_hsa052190.14916212
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14185053
99Chemical carcinogenesis_Homo sapiens_hsa052040.13912241
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13015615

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