APOL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)5.22147618
2indole-containing compound catabolic process (GO:0042436)5.22147618
3indolalkylamine catabolic process (GO:0046218)5.22147618
4indolalkylamine metabolic process (GO:0006586)4.94846344
5kynurenine metabolic process (GO:0070189)4.66633700
6tryptophan metabolic process (GO:0006568)4.62121452
7cellular response to ethanol (GO:0071361)4.59595154
8signal peptide processing (GO:0006465)4.44795693
9regulation of pigment cell differentiation (GO:0050932)4.27130329
10cilium or flagellum-dependent cell motility (GO:0001539)4.15165513
11positive regulation of developmental pigmentation (GO:0048087)4.10753773
12monoubiquitinated protein deubiquitination (GO:0035520)4.00036237
13interkinetic nuclear migration (GO:0022027)3.94742666
14regulation of sarcomere organization (GO:0060297)3.75955297
15protein K48-linked deubiquitination (GO:0071108)3.70132033
16detection of light stimulus involved in visual perception (GO:0050908)3.62170503
17detection of light stimulus involved in sensory perception (GO:0050962)3.62170503
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51434105
19photoreceptor cell maintenance (GO:0045494)3.51189562
20protein K11-linked deubiquitination (GO:0035871)3.42509841
21establishment of protein localization to Golgi (GO:0072600)3.39730554
22indole-containing compound metabolic process (GO:0042430)3.39565272
23NAD biosynthetic process (GO:0009435)3.32677065
24benzene-containing compound metabolic process (GO:0042537)3.30268232
25cellular biogenic amine catabolic process (GO:0042402)3.17580871
26amine catabolic process (GO:0009310)3.17580871
27cellular ketone body metabolic process (GO:0046950)3.15792089
28regulation of hippo signaling (GO:0035330)3.07730240
29protein K63-linked deubiquitination (GO:0070536)3.04198402
30regulation of MHC class II biosynthetic process (GO:0045346)3.01587856
31neural tube formation (GO:0001841)2.99699726
32tachykinin receptor signaling pathway (GO:0007217)2.97394579
33phospholipid translocation (GO:0045332)2.92982805
34lipid translocation (GO:0034204)2.92982805
35negative regulation of complement activation (GO:0045916)2.91103642
36prenylation (GO:0097354)2.90727937
37protein prenylation (GO:0018342)2.90727937
38UDP-N-acetylglucosamine metabolic process (GO:0006047)2.90575196
39auditory receptor cell stereocilium organization (GO:0060088)2.88041235
40L-fucose catabolic process (GO:0042355)2.87476919
41fucose catabolic process (GO:0019317)2.87476919
42L-fucose metabolic process (GO:0042354)2.87476919
43ketone body metabolic process (GO:1902224)2.77391713
44aromatic amino acid family catabolic process (GO:0009074)2.72210394
45negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70063253
46snRNA transcription (GO:0009301)2.69194028
47negative regulation of translation, ncRNA-mediated (GO:0040033)2.67302737
48regulation of translation, ncRNA-mediated (GO:0045974)2.67302737
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67302737
50phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67183180
51regulation of establishment of cell polarity (GO:2000114)2.64851635
52axoneme assembly (GO:0035082)2.62896772
53one-carbon compound transport (GO:0019755)2.61930247
54thyroid hormone metabolic process (GO:0042403)2.60939270
55gamma-aminobutyric acid transport (GO:0015812)2.60170193
56reflex (GO:0060004)2.59570337
57behavioral response to nicotine (GO:0035095)2.51854446
58regulation of posttranscriptional gene silencing (GO:0060147)2.51815333
59regulation of gene silencing by miRNA (GO:0060964)2.51815333
60regulation of gene silencing by RNA (GO:0060966)2.51815333
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.51660971
62regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.51635043
63negative regulation of protein activation cascade (GO:2000258)2.51358980
64aromatic amino acid family metabolic process (GO:0009072)2.51021594
65flavonoid metabolic process (GO:0009812)2.50449704
66serotonin metabolic process (GO:0042428)2.50116078
67cellular response to sterol (GO:0036315)2.49284071
68negative regulation of systemic arterial blood pressure (GO:0003085)2.48022793
69sphingoid metabolic process (GO:0046519)2.47873654
70oxidative demethylation (GO:0070989)2.46937235
71regulation of interleukin-12 biosynthetic process (GO:0045075)2.46341644
72regulation of B cell receptor signaling pathway (GO:0050855)2.46162135
73primary amino compound metabolic process (GO:1901160)2.45711567
74regulation of skeletal muscle contraction (GO:0014819)2.45559540
75regulation of establishment or maintenance of cell polarity (GO:0032878)2.45029753
76negative regulation of mast cell activation (GO:0033004)2.44154029
77positive regulation of oligodendrocyte differentiation (GO:0048714)2.44038091
78negative regulation of immunoglobulin mediated immune response (GO:0002890)2.43934343
79negative regulation of B cell mediated immunity (GO:0002713)2.43934343
80pyridine nucleotide biosynthetic process (GO:0019363)2.40241998
81nicotinamide nucleotide biosynthetic process (GO:0019359)2.40241998
82membrane depolarization during action potential (GO:0086010)2.39291612
83positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.36411243
84DNA demethylation (GO:0080111)2.36231582
85protein targeting to vacuole (GO:0006623)2.35761034
86protein targeting to lysosome (GO:0006622)2.35761034
87establishment of protein localization to vacuole (GO:0072666)2.35761034
88regulation of memory T cell differentiation (GO:0043380)2.35069994
89striated muscle atrophy (GO:0014891)2.34722127
90regulation of developmental pigmentation (GO:0048070)2.34563451
91phosphatidylinositol acyl-chain remodeling (GO:0036149)2.34133179
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33890736
93sulfation (GO:0051923)2.33822555
94cytokine biosynthetic process (GO:0042089)2.33587279
95negative regulation of calcium ion transport into cytosol (GO:0010523)2.32751085
96behavioral response to ethanol (GO:0048149)2.32376512
97positive regulation of phosphatase activity (GO:0010922)2.31137602
98histone H3-K4 trimethylation (GO:0080182)2.29630834
99negative regulation of humoral immune response (GO:0002921)2.29066971
100cAMP catabolic process (GO:0006198)2.28308046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.15149188
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67547695
3VDR_22108803_ChIP-Seq_LS180_Human2.65877448
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.59353651
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.51543576
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42701972
7ZNF274_21170338_ChIP-Seq_K562_Hela2.39827813
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36362850
9IGF1R_20145208_ChIP-Seq_DFB_Human2.28328200
10AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13946212
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08890410
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07131031
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06195098
14TAF15_26573619_Chip-Seq_HEK293_Human2.00605404
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.92202177
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.91596153
17STAT3_23295773_ChIP-Seq_U87_Human1.88620525
18ER_23166858_ChIP-Seq_MCF-7_Human1.87804748
19P300_19829295_ChIP-Seq_ESCs_Human1.86367335
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85912960
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.80710552
22SMAD4_21799915_ChIP-Seq_A2780_Human1.79614890
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71011776
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67880546
25TCF4_23295773_ChIP-Seq_U87_Human1.65299829
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64348074
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.60200247
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59739865
29GATA1_22025678_ChIP-Seq_K562_Human1.59013024
30EWS_26573619_Chip-Seq_HEK293_Human1.58930153
31BCAT_22108803_ChIP-Seq_LS180_Human1.58727258
32FUS_26573619_Chip-Seq_HEK293_Human1.58330934
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58025160
34AR_21572438_ChIP-Seq_LNCaP_Human1.57933021
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53675853
36CBP_20019798_ChIP-Seq_JUKART_Human1.53675853
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53260741
38EZH2_22144423_ChIP-Seq_EOC_Human1.51210227
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48014672
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46790446
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43889244
42PRDM14_20953172_ChIP-Seq_ESCs_Human1.43806286
43TP53_16413492_ChIP-PET_HCT116_Human1.42833909
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42604656
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42604656
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42294045
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42017037
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41099728
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40825677
50AR_25329375_ChIP-Seq_VCAP_Human1.40416575
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.39070725
52* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35662338
53TCF4_22108803_ChIP-Seq_LS180_Human1.35194233
54AHR_22903824_ChIP-Seq_MCF-7_Human1.34655584
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34534820
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.32326720
57CDX2_22108803_ChIP-Seq_LS180_Human1.31452303
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31013226
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30186899
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29126325
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.26947857
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26592588
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25896269
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.25797558
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25526740
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25166269
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25147256
68RUNX2_22187159_ChIP-Seq_PCA_Human1.22728219
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.22618932
70SCL_19346495_ChIP-Seq_HPC-7_Human1.22482489
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.21718645
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21391672
73DROSHA_22980978_ChIP-Seq_HELA_Human1.19399266
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18732586
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17409448
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.17339587
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.17108885
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.16007583
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15952343
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15013484
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14455085
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12477885
83NANOG_19829295_ChIP-Seq_ESCs_Human1.11939439
84SOX2_19829295_ChIP-Seq_ESCs_Human1.11939439
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10791895
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10791895
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.09757073
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08415785
89P53_22387025_ChIP-Seq_ESCs_Mouse1.07792381
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07320387
91VDR_24787735_ChIP-Seq_THP-1_Human1.06914063
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06326618
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.05992802
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04268536
95KDM2B_26808549_Chip-Seq_REH_Human1.03937173
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.03083189
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02989685
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02913736
99RXR_22108803_ChIP-Seq_LS180_Human1.02808940
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01494177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.97978269
2MP0003195_calcinosis3.50948164
3MP0008057_abnormal_DNA_replication3.37207730
4MP0001501_abnormal_sleep_pattern2.87456791
5MP0002138_abnormal_hepatobiliary_system2.53652068
6MP0003045_fibrosis2.42115947
7MP0003646_muscle_fatigue2.40886643
8MP0005551_abnormal_eye_electrophysiolog2.26225869
9MP0004043_abnormal_pH_regulation2.22055099
10MP0004147_increased_porphyrin_level2.11460310
11MP0005174_abnormal_tail_pigmentation2.01094450
12MP0009046_muscle_twitch2.00028802
13MP0002102_abnormal_ear_morphology1.89503125
14MP0010386_abnormal_urinary_bladder1.87650422
15MP0001968_abnormal_touch/_nociception1.84263730
16MP0005310_abnormal_salivary_gland1.79477774
17MP0001986_abnormal_taste_sensitivity1.78234788
18MP0005646_abnormal_pituitary_gland1.77040356
19MP0005670_abnormal_white_adipose1.73194992
20MP0005253_abnormal_eye_physiology1.71794583
21MP0005671_abnormal_response_to1.71192143
22MP0000383_abnormal_hair_follicle1.70941924
23MP0003950_abnormal_plasma_membrane1.69225618
24MP0008872_abnormal_physiological_respon1.61606348
25MP0001835_abnormal_antigen_presentation1.60490689
26MP0002736_abnormal_nociception_after1.60064929
27MP0003252_abnormal_bile_duct1.58612433
28MP0000427_abnormal_hair_cycle1.57302666
29MP0005167_abnormal_blood-brain_barrier1.47934515
30MP0003724_increased_susceptibility_to1.46751592
31MP0008877_abnormal_DNA_methylation1.46115098
32MP0002168_other_aberrant_phenotype1.38204256
33MP0005085_abnormal_gallbladder_physiolo1.36585667
34MP0002837_dystrophic_cardiac_calcinosis1.35794576
35MP0004145_abnormal_muscle_electrophysio1.34887554
36MP0002876_abnormal_thyroid_physiology1.33752840
37MP0003656_abnormal_erythrocyte_physiolo1.24157696
38MP0009745_abnormal_behavioral_response1.22536281
39MP0001485_abnormal_pinna_reflex1.21004392
40MP0004142_abnormal_muscle_tone1.20631925
41MP0001800_abnormal_humoral_immune1.18954416
42MP0000015_abnormal_ear_pigmentation1.18179701
43MP0006082_CNS_inflammation1.16386899
44MP0004130_abnormal_muscle_cell1.14549008
45MP0000230_abnormal_systemic_arterial1.13728499
46MP0003183_abnormal_peptide_metabolism1.13446594
47MP0006054_spinal_hemorrhage1.13439169
48MP0009764_decreased_sensitivity_to1.07215786
49MP0002928_abnormal_bile_duct1.06614157
50MP0002148_abnormal_hypersensitivity_rea1.05704551
51MP0002095_abnormal_skin_pigmentation1.04162922
52MP0000371_diluted_coat_color1.03783410
53MP0005645_abnormal_hypothalamus_physiol1.03686604
54MP0001486_abnormal_startle_reflex1.02016093
55MP0004215_abnormal_myocardial_fiber0.99785345
56MP0002229_neurodegeneration0.99421201
57MP0005266_abnormal_metabolism0.99212325
58MP0003633_abnormal_nervous_system0.98887460
59MP0000372_irregular_coat_pigmentation0.98596107
60MP0003787_abnormal_imprinting0.97423855
61MP0002693_abnormal_pancreas_physiology0.97406867
62MP0005075_abnormal_melanosome_morpholog0.96623674
63MP0005647_abnormal_sex_gland0.93802699
64MP0009115_abnormal_fat_cell0.93405190
65MP0005083_abnormal_biliary_tract0.92967863
66MP0004924_abnormal_behavior0.92673024
67MP0005386_behavior/neurological_phenoty0.92673024
68MP0004084_abnormal_cardiac_muscle0.91736263
69MP0006276_abnormal_autonomic_nervous0.91629850
70MP0001790_abnormal_immune_system0.90930624
71MP0005387_immune_system_phenotype0.90930624
72MP0005395_other_phenotype0.90557934
73MP0001756_abnormal_urination0.89739324
74MP0002735_abnormal_chemical_nociception0.89280850
75MP0001545_abnormal_hematopoietic_system0.88659654
76MP0005397_hematopoietic_system_phenotyp0.88659654
77MP0000538_abnormal_urinary_bladder0.88204856
78MP0002272_abnormal_nervous_system0.87054356
79MP0006072_abnormal_retinal_apoptosis0.86563996
80MP0001970_abnormal_pain_threshold0.86424913
81MP0002723_abnormal_immune_serum0.86025713
82MP0010678_abnormal_skin_adnexa0.85154918
83MP0002064_seizures0.82399894
84MP0002452_abnormal_antigen_presenting0.82265907
85MP0002067_abnormal_sensory_capabilities0.81882103
86MP0002733_abnormal_thermal_nociception0.81177095
87MP0002572_abnormal_emotion/affect_behav0.81147087
88MP0001984_abnormal_olfaction0.78910306
89MP0010329_abnormal_lipoprotein_level0.78888335
90MP0001764_abnormal_homeostasis0.78425472
91MP0002638_abnormal_pupillary_reflex0.75819375
92MP0000516_abnormal_urinary_system0.75623321
93MP0005367_renal/urinary_system_phenotyp0.75623321
94MP0003879_abnormal_hair_cell0.75525891
95MP0003631_nervous_system_phenotype0.75263236
96MP0008961_abnormal_basal_metabolism0.75217222
97MP0005365_abnormal_bile_salt0.73108546
98MP0000631_abnormal_neuroendocrine_gland0.72434416
99MP0005376_homeostasis/metabolism_phenot0.70853947
100MP0004036_abnormal_muscle_relaxation0.69831155

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.22458675
2Hyperventilation (HP:0002883)4.77526085
3Pancreatic cysts (HP:0001737)4.21066033
4Gaze-evoked nystagmus (HP:0000640)4.18368717
5Progressive cerebellar ataxia (HP:0002073)3.89912923
6Increased neuronal autofluorescent lipopigment (HP:0002074)3.83019937
7Attenuation of retinal blood vessels (HP:0007843)3.66303171
8Pancreatic fibrosis (HP:0100732)3.66131683
9Congenital stationary night blindness (HP:0007642)3.57499976
10Clumsiness (HP:0002312)3.56990381
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.40707960
12True hermaphroditism (HP:0010459)3.26913949
13Fair hair (HP:0002286)3.25445141
14Increased cerebral lipofuscin (HP:0011813)3.10816073
15Abolished electroretinogram (ERG) (HP:0000550)3.07831338
16Protruding tongue (HP:0010808)3.06824701
17Nephronophthisis (HP:0000090)3.06762714
18Abnormality of the renal cortex (HP:0011035)3.05732246
19Chronic hepatic failure (HP:0100626)3.04910472
20Febrile seizures (HP:0002373)3.00949238
21Abnormality of the renal medulla (HP:0100957)2.95403694
22Congenital sensorineural hearing impairment (HP:0008527)2.89544163
23Cystic liver disease (HP:0006706)2.85031918
24Decreased circulating renin level (HP:0003351)2.78051135
25Abnormality of midbrain morphology (HP:0002418)2.76125021
26Molar tooth sign on MRI (HP:0002419)2.76125021
27Facial diplegia (HP:0001349)2.73717436
28Absent speech (HP:0001344)2.68414408
29Stomach cancer (HP:0012126)2.62944399
30Generalized hypopigmentation of hair (HP:0011358)2.58831753
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.52533515
32Widely spaced teeth (HP:0000687)2.50011186
33Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49427017
34Progressive inability to walk (HP:0002505)2.48055655
35Congenital hepatic fibrosis (HP:0002612)2.42072937
36Medial flaring of the eyebrow (HP:0010747)2.40857986
37Bony spicule pigmentary retinopathy (HP:0007737)2.40633382
38Abnormal drinking behavior (HP:0030082)2.37557161
39Polydipsia (HP:0001959)2.37557161
40Central scotoma (HP:0000603)2.30848610
41Dysmetric saccades (HP:0000641)2.26351120
42Constricted visual fields (HP:0001133)2.26318319
43Inability to walk (HP:0002540)2.23695508
44Tubular atrophy (HP:0000092)2.19640923
45Abnormality of alanine metabolism (HP:0010916)2.19186608
46Hyperalaninemia (HP:0003348)2.19186608
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19186608
48Dialeptic seizures (HP:0011146)2.15032736
49Hypothermia (HP:0002045)2.12612435
50Furrowed tongue (HP:0000221)2.10395222
51Decreased central vision (HP:0007663)2.07807806
52Keratoconus (HP:0000563)2.06936384
53Increased corneal curvature (HP:0100692)2.06936384
54Broad-based gait (HP:0002136)2.06601461
55Tubulointerstitial nephritis (HP:0001970)2.04735475
56Thyroiditis (HP:0100646)2.03057035
57Aplasia/Hypoplasia of the tongue (HP:0010295)1.97976142
58Macular degeneration (HP:0000608)1.97303931
59Recurrent cutaneous fungal infections (HP:0011370)1.95937426
60Chronic mucocutaneous candidiasis (HP:0002728)1.95937426
61Hematochezia (HP:0002573)1.93103635
62Prostate neoplasm (HP:0100787)1.93054076
63Focal seizures (HP:0007359)1.91414447
64Abnormal delayed hypersensitivity skin test (HP:0002963)1.90845226
65Renal cortical cysts (HP:0000803)1.90511994
66Abnormal biliary tract physiology (HP:0012439)1.90361268
67Bile duct proliferation (HP:0001408)1.90361268
68Tubulointerstitial abnormality (HP:0001969)1.88806619
69Abnormal rod and cone electroretinograms (HP:0008323)1.87650701
70Autoimmune thrombocytopenia (HP:0001973)1.87357446
71Portal hypertension (HP:0001409)1.84179111
72Nephrogenic diabetes insipidus (HP:0009806)1.83908196
73Ketoacidosis (HP:0001993)1.81413533
74Urinary bladder sphincter dysfunction (HP:0002839)1.79265573
75Scotoma (HP:0000575)1.79004850
76Congenital primary aphakia (HP:0007707)1.78733295
77Absence seizures (HP:0002121)1.78619422
78Hyperkalemia (HP:0002153)1.78404851
79Ileus (HP:0002595)1.77291915
80Gait imbalance (HP:0002141)1.76835684
81Large for gestational age (HP:0001520)1.76367067
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76301387
83Abnormality of binocular vision (HP:0011514)1.76231842
84Diplopia (HP:0000651)1.76231842
85Abnormal ciliary motility (HP:0012262)1.75274987
86Progressive visual loss (HP:0000529)1.74833096
87Impaired smooth pursuit (HP:0007772)1.71567695
88Abnormality of T cell number (HP:0011839)1.70875462
89Hemiparesis (HP:0001269)1.70560676
90Polyuria (HP:0000103)1.68926589
91Ketosis (HP:0001946)1.64918558
92Spontaneous hematomas (HP:0007420)1.64906046
93Albinism (HP:0001022)1.64678934
94Abnormality of the hepatic vasculature (HP:0006707)1.63894243
95Atonic seizures (HP:0010819)1.63640752
96Postural instability (HP:0002172)1.62500157
97Abnormality of the prostate (HP:0008775)1.62142830
98Pigmentary retinal degeneration (HP:0001146)1.62120170
99Absent/shortened dynein arms (HP:0200106)1.62108140
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.62108140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.35384193
2ACVR1B3.51053490
3TAOK32.71937575
4BMPR1B2.44493862
5MAP4K22.20442122
6AKT32.19176226
7ADRBK22.12398979
8PIK3CG1.99094615
9BLK1.83543777
10INSRR1.71152241
11STK38L1.70067578
12GRK11.66787833
13NUAK11.62987415
14TXK1.59586547
15LATS11.52780948
16TRPM71.43031478
17MAPK131.39901527
18TEC1.38639263
19NTRK31.25733717
20OXSR11.24794895
21DAPK21.18954323
22WNK31.12389542
23PIK3CA1.11655051
24MKNK21.11250703
25MAP3K41.09212446
26KIT1.09074276
27ADRBK11.07631270
28SGK21.06355782
29NLK1.02227738
30EPHA31.01920064
31PINK10.99133162
32BRD40.98946727
33IRAK10.97766856
34PRKAA20.93534091
35PTK2B0.89564240
36TNK20.88101008
37ITK0.85775409
38JAK10.85622267
39ZAK0.83620735
40STK390.83051526
41OBSCN0.80873542
42MAP3K70.80767119
43STK30.79138762
44IKBKB0.78873331
45CASK0.77254984
46SYK0.76614109
47BMPR20.73526999
48CAMK1D0.69527552
49MAPKAPK30.68969891
50MELK0.68143223
51CAMK1G0.67645881
52FER0.67378100
53PRKCE0.67184178
54BTK0.66334148
55TGFBR10.65656616
56STK380.64497911
57CAMKK20.59202460
58TNIK0.55324825
59JAK30.53818101
60MAPKAPK50.53125645
61RIPK40.52497887
62CHUK0.52436135
63LYN0.51999423
64GRK70.51454819
65SGK4940.50898390
66SGK2230.50898390
67CDK120.50175955
68PAK30.49882294
69MAPK110.49590760
70JAK20.48360384
71EIF2AK30.48015568
72FGFR30.47904652
73PDK20.47858789
74MAP3K140.47733316
75PRKCQ0.47275902
76FGFR20.47053026
77LCK0.46655202
78TYK20.45864202
79FES0.44674392
80IKBKE0.43838558
81HCK0.43804190
82MUSK0.43135407
83BRSK20.43096194
84WNK10.42864174
85PRKAA10.42753504
86NEK60.41573791
87SGK10.40927949
88PRKACB0.38268471
89ERBB20.38256426
90ABL10.38124341
91PDK10.37947168
92SGK30.35434860
93PKN10.35082884
94MARK30.34679443
95CAMK40.34434307
96CAMK10.33805037
97IGF1R0.33191682
98WNK40.32708197
99DYRK1A0.32553885
100MAP2K60.32078082

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.51175921
2Butanoate metabolism_Homo sapiens_hsa006502.29829767
3ABC transporters_Homo sapiens_hsa020102.17758722
4Tryptophan metabolism_Homo sapiens_hsa003802.14148516
5Phototransduction_Homo sapiens_hsa047442.13141276
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.12229891
7Linoleic acid metabolism_Homo sapiens_hsa005912.07753982
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07354498
9Graft-versus-host disease_Homo sapiens_hsa053322.05865664
10Staphylococcus aureus infection_Homo sapiens_hsa051501.93539430
11Nitrogen metabolism_Homo sapiens_hsa009101.92058924
12Allograft rejection_Homo sapiens_hsa053301.84840301
13Autoimmune thyroid disease_Homo sapiens_hsa053201.73702832
14Type I diabetes mellitus_Homo sapiens_hsa049401.71768754
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66745267
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63285751
17Nicotine addiction_Homo sapiens_hsa050331.57412470
18Ether lipid metabolism_Homo sapiens_hsa005651.53292603
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48371965
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46608841
21Taste transduction_Homo sapiens_hsa047421.45895393
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.43330571
23Dorso-ventral axis formation_Homo sapiens_hsa043201.40585980
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37818606
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35987818
26Histidine metabolism_Homo sapiens_hsa003401.34662945
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.26510359
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.26143063
29Morphine addiction_Homo sapiens_hsa050321.23478762
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23216556
31Circadian entrainment_Homo sapiens_hsa047131.12831454
32Serotonergic synapse_Homo sapiens_hsa047261.09898491
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.08864415
34Salivary secretion_Homo sapiens_hsa049701.08232115
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07876224
36Selenocompound metabolism_Homo sapiens_hsa004501.05423215
37Olfactory transduction_Homo sapiens_hsa047401.05163688
38Glycerolipid metabolism_Homo sapiens_hsa005611.04479124
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00900411
40Chemical carcinogenesis_Homo sapiens_hsa052041.00225221
41Ovarian steroidogenesis_Homo sapiens_hsa049131.00008228
42Hematopoietic cell lineage_Homo sapiens_hsa046400.99239315
43Calcium signaling pathway_Homo sapiens_hsa040200.98557079
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98035851
45Glutamatergic synapse_Homo sapiens_hsa047240.97988779
46Arachidonic acid metabolism_Homo sapiens_hsa005900.96994575
47Lysine degradation_Homo sapiens_hsa003100.95609007
48Retinol metabolism_Homo sapiens_hsa008300.92330165
49Renin secretion_Homo sapiens_hsa049240.90597019
50Sphingolipid metabolism_Homo sapiens_hsa006000.90179324
51Type II diabetes mellitus_Homo sapiens_hsa049300.89032640
52Rheumatoid arthritis_Homo sapiens_hsa053230.88764257
53Propanoate metabolism_Homo sapiens_hsa006400.88742092
54Circadian rhythm_Homo sapiens_hsa047100.88337585
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.87490583
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86386988
57Homologous recombination_Homo sapiens_hsa034400.86079317
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85952699
59GABAergic synapse_Homo sapiens_hsa047270.83775113
60beta-Alanine metabolism_Homo sapiens_hsa004100.83191739
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78664113
62Leishmaniasis_Homo sapiens_hsa051400.77990600
63Pancreatic secretion_Homo sapiens_hsa049720.77910473
64Platelet activation_Homo sapiens_hsa046110.77445534
65Fatty acid biosynthesis_Homo sapiens_hsa000610.77382213
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74444336
67Long-term depression_Homo sapiens_hsa047300.73678946
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72715396
69Tuberculosis_Homo sapiens_hsa051520.70199887
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.69028371
71Insulin secretion_Homo sapiens_hsa049110.68923383
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68309916
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68211168
74Regulation of autophagy_Homo sapiens_hsa041400.67423338
75Antigen processing and presentation_Homo sapiens_hsa046120.66083322
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65654819
77Primary immunodeficiency_Homo sapiens_hsa053400.64831186
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63820061
79Caffeine metabolism_Homo sapiens_hsa002320.62733876
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58905894
81Cholinergic synapse_Homo sapiens_hsa047250.58826661
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58192792
83Oxytocin signaling pathway_Homo sapiens_hsa049210.57369124
84Complement and coagulation cascades_Homo sapiens_hsa046100.54936028
85Fatty acid degradation_Homo sapiens_hsa000710.53863205
86Fanconi anemia pathway_Homo sapiens_hsa034600.53833790
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.52396013
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51769755
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50839232
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50350391
91Lysosome_Homo sapiens_hsa041420.48671654
92African trypanosomiasis_Homo sapiens_hsa051430.48148925
93Peroxisome_Homo sapiens_hsa041460.48093746
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46541767
95cAMP signaling pathway_Homo sapiens_hsa040240.46280155
96Gastric acid secretion_Homo sapiens_hsa049710.46155703
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43729049
98Influenza A_Homo sapiens_hsa051640.41785509
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38050576
100Mineral absorption_Homo sapiens_hsa049780.37286577

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