APOL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)8.87501998
2regulation of sequestering of triglyceride (GO:0010889)7.94848732
3triglyceride catabolic process (GO:0019433)7.35227602
4white fat cell differentiation (GO:0050872)7.24797248
5brown fat cell differentiation (GO:0050873)7.06522509
6biotin metabolic process (GO:0006768)6.60743702
7acylglycerol catabolic process (GO:0046464)6.45352380
8neutral lipid catabolic process (GO:0046461)6.45352380
9valine metabolic process (GO:0006573)6.44989295
10fatty acid transmembrane transport (GO:1902001)5.90729104
11lipid particle organization (GO:0034389)5.78327863
12carnitine shuttle (GO:0006853)5.51112949
13positive regulation of fatty acid beta-oxidation (GO:0032000)5.45857397
14positive regulation of fatty acid oxidation (GO:0046321)5.41251802
15triglyceride biosynthetic process (GO:0019432)5.19284177
16negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.18959897
17response to dietary excess (GO:0002021)5.15680048
18lipid storage (GO:0019915)5.04331430
19regulation of cholesterol storage (GO:0010885)5.04308474
20positive regulation of gamma-delta T cell activation (GO:0046645)4.98066141
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.97877429
22glycerolipid catabolic process (GO:0046503)4.96355728
23fatty acid beta-oxidation (GO:0006635)4.95682934
24neutral lipid biosynthetic process (GO:0046460)4.95373263
25acylglycerol biosynthetic process (GO:0046463)4.95373263
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.94504101
27negative regulation of protein autophosphorylation (GO:0031953)4.89120141
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.74928173
29negative regulation of granulocyte differentiation (GO:0030853)4.74230271
30negative regulation of cell killing (GO:0031342)4.72242603
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.72242603
32protein heterotrimerization (GO:0070208)4.64471471
33antigen processing and presentation of endogenous antigen (GO:0019883)4.60464504
34regulation of cAMP-dependent protein kinase activity (GO:2000479)4.59469886
35branched-chain amino acid metabolic process (GO:0009081)4.56554511
36response to type I interferon (GO:0034340)4.50175273
37type I interferon signaling pathway (GO:0060337)4.48924821
38cellular response to type I interferon (GO:0071357)4.48924821
39carnitine transmembrane transport (GO:1902603)4.32279785
40ovulation from ovarian follicle (GO:0001542)4.28335729
41branched-chain amino acid catabolic process (GO:0009083)4.26857468
42negative regulation of macrophage differentiation (GO:0045650)4.23869023
43sulfur amino acid catabolic process (GO:0000098)4.21265497
44fatty acid oxidation (GO:0019395)4.19757467
45fatty-acyl-CoA biosynthetic process (GO:0046949)4.18868147
46long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.17970224
47fatty-acyl-CoA metabolic process (GO:0035337)4.16419494
48lipid oxidation (GO:0034440)4.13409858
49fatty acid catabolic process (GO:0009062)4.08765078
50regulation of fatty acid oxidation (GO:0046320)4.07227302
51thioester biosynthetic process (GO:0035384)4.05773487
52acyl-CoA biosynthetic process (GO:0071616)4.05773487
53regulation of B cell receptor signaling pathway (GO:0050855)3.95155547
54regulation of gamma-delta T cell activation (GO:0046643)3.91582126
55long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.90414057
56carnitine transport (GO:0015879)3.86599347
57amino-acid betaine transport (GO:0015838)3.86599347
58cellular response to lithium ion (GO:0071285)3.86429378
59modulation by symbiont of host defense response (GO:0052031)3.85654080
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85654080
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85654080
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.85654080
63modulation by symbiont of host immune response (GO:0052553)3.85654080
64positive regulation by symbiont of host defense response (GO:0052509)3.85654080
65triglyceride metabolic process (GO:0006641)3.82440743
66positive regulation of glucose import (GO:0046326)3.79278678
67macrophage activation involved in immune response (GO:0002281)3.77920584
68fatty acid homeostasis (GO:0055089)3.76255952
69positive regulation of cellular response to insulin stimulus (GO:1900078)3.75245318
70glycerol metabolic process (GO:0006071)3.74367409
71regulation of fatty acid beta-oxidation (GO:0031998)3.72255810
72detection of molecule of bacterial origin (GO:0032490)3.70800916
73detection of other organism (GO:0098543)3.68639512
74positive regulation of glomerulus development (GO:0090193)3.66301755
75regulation of macrophage chemotaxis (GO:0010758)3.65208258
76negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.59328828
77regulation of glycogen (starch) synthase activity (GO:2000465)3.59076528
78negative regulation of interleukin-12 production (GO:0032695)3.58176591
79negative regulation of phagocytosis (GO:0050765)3.57742698
80regulation of gamma-delta T cell differentiation (GO:0045586)3.56397098
81negative regulation of lipid storage (GO:0010888)3.55758144
82coenzyme A biosynthetic process (GO:0015937)3.55130929
83acylglycerol metabolic process (GO:0006639)3.54945591
84interferon-gamma-mediated signaling pathway (GO:0060333)3.53820625
85acetyl-CoA metabolic process (GO:0006084)3.50413265
86regulation of macrophage derived foam cell differentiation (GO:0010743)3.50314254
87neutral lipid metabolic process (GO:0006638)3.49409272
88positive regulation of insulin receptor signaling pathway (GO:0046628)3.46836359
89positive regulation of lipid catabolic process (GO:0050996)3.46815484
90L-serine transport (GO:0015825)3.45348331
91positive regulation of fatty acid metabolic process (GO:0045923)3.44858673
92negative regulation of metanephros development (GO:0072217)3.42057248
93regulation of interferon-beta biosynthetic process (GO:0045357)3.41480615
94positive regulation of cholesterol efflux (GO:0010875)3.41316435
95cellular response to epinephrine stimulus (GO:0071872)3.41035887
96negative regulation of appetite (GO:0032099)3.40238567
97negative regulation of response to food (GO:0032096)3.40238567
98endocrine hormone secretion (GO:0060986)3.39890308
99detection of external biotic stimulus (GO:0098581)3.39867021
100intracellular lipid transport (GO:0032365)3.38940661
101positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38812348
102plasma lipoprotein particle clearance (GO:0034381)3.38526737
103positive regulation of lipid storage (GO:0010884)3.36923968
104detection of bacterium (GO:0016045)3.36860832
105negative regulation of T cell mediated immunity (GO:0002710)3.35747008
106regulation of interferon-alpha production (GO:0032647)3.30808769
107regulation of T cell tolerance induction (GO:0002664)3.29845413
108positive regulation of interferon-alpha production (GO:0032727)3.28730592
109negative regulation of lymphocyte mediated immunity (GO:0002707)3.26410104
110regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.26219090
111retina vasculature morphogenesis in camera-type eye (GO:0061299)3.25954576
112oxaloacetate metabolic process (GO:0006107)3.25661873
113tyrosine phosphorylation of STAT protein (GO:0007260)3.23684043
114CDP-diacylglycerol biosynthetic process (GO:0016024)3.23554912
115regulation of regulatory T cell differentiation (GO:0045589)3.20901350
116negative regulation of gluconeogenesis (GO:0045721)3.19483177
117positive regulation of sterol transport (GO:0032373)3.19356143
118positive regulation of cholesterol transport (GO:0032376)3.19356143
119regulation of gonadotropin secretion (GO:0032276)3.17684840
120T cell migration (GO:0072678)3.17151040
121regulation of tolerance induction (GO:0002643)3.17102282
122interferon-gamma production (GO:0032609)3.14714693
123alditol metabolic process (GO:0019400)3.14569329
124positive regulation of fat cell differentiation (GO:0045600)3.12098142
125positive regulation of glucose transport (GO:0010828)3.11660367
126positive regulation of steroid hormone secretion (GO:2000833)3.11359929
127negative regulation of nitric-oxide synthase activity (GO:0051001)3.11137175
128response to folic acid (GO:0051593)3.10681198
129glomerular filtration (GO:0003094)3.10439909
130immunoglobulin mediated immune response (GO:0016064)3.09968386
131growth hormone receptor signaling pathway (GO:0060396)3.09445185
132microglial cell activation (GO:0001774)3.08912867
133negative T cell selection (GO:0043383)3.07627168
134regulation of lipid storage (GO:0010883)3.06847179
135negative thymic T cell selection (GO:0045060)3.06212021
136regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.05120287
137positive regulation of tolerance induction (GO:0002645)3.04755376
138positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04528565
139cellular extravasation (GO:0045123)3.03789837
140cellular response to ethanol (GO:0071361)3.03125609
141cellular lipid catabolic process (GO:0044242)3.03087964
142transcytosis (GO:0045056)3.03009271
143response to interleukin-15 (GO:0070672)3.00398531
144regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.00338396
145response to interferon-alpha (GO:0035455)2.98451157
146fat cell differentiation (GO:0045444)2.98117997
147negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.96891956
148quaternary ammonium group transport (GO:0015697)2.96253310
149regulation of interleukin-12 biosynthetic process (GO:0045075)2.95369791
150response to peptidoglycan (GO:0032494)2.94452873
151detection of biotic stimulus (GO:0009595)2.91646892
152regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91586934
153neutrophil activation involved in immune response (GO:0002283)2.87263367
154response to host immune response (GO:0052572)2.86094029
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86094029
156negative regulation of viral genome replication (GO:0045071)2.84423817
157germinal center formation (GO:0002467)2.82133295
158macrophage activation (GO:0042116)2.80705966
159negative regulation of leukocyte mediated immunity (GO:0002704)2.79168700
160positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78234319
161production of molecular mediator involved in inflammatory response (GO:0002532)2.76633074
162cellular response to interleukin-15 (GO:0071350)2.74709805
163regulation of T cell mediated cytotoxicity (GO:0001914)2.74438826
164defense response to protozoan (GO:0042832)2.74334509
165tolerance induction (GO:0002507)2.73668780
166positive regulation of type 2 immune response (GO:0002830)2.69262799
167T-helper 1 type immune response (GO:0042088)2.69261759
168regulation of alpha-beta T cell proliferation (GO:0046640)2.67464168
169response to host (GO:0075136)2.66861400
170response to host defenses (GO:0052200)2.66861400
171response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66861400
172JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66416777
173regulation of necroptotic process (GO:0060544)2.65975338
174B cell receptor signaling pathway (GO:0050853)2.65784521
175regulation of MHC class I biosynthetic process (GO:0045343)2.65693674
176positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.65645319
177negative regulation of innate immune response (GO:0045824)2.64855569
178cellular response to interferon-gamma (GO:0071346)2.63762705
179response to interferon-beta (GO:0035456)2.63066902
180positive regulation of interferon-beta production (GO:0032728)2.62959406
181antigen processing and presentation via MHC class Ib (GO:0002475)2.62344162
182regulation of T-helper 1 cell differentiation (GO:0045625)2.61080524
183leukocyte aggregation (GO:0070486)2.60483487
184positive regulation of toll-like receptor signaling pathway (GO:0034123)2.59790110
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59027847
186negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.58780687
187activated T cell proliferation (GO:0050798)2.58296454
188dendritic cell migration (GO:0036336)2.57106814
189positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56876401
190defense response to virus (GO:0051607)2.55932207
191myeloid cell activation involved in immune response (GO:0002275)2.55189784
192positive regulation of antigen processing and presentation (GO:0002579)2.54899651
193positive thymic T cell selection (GO:0045059)2.54665211
194response to interferon-gamma (GO:0034341)2.53742568
195cellular response to exogenous dsRNA (GO:0071360)2.53419884
196response to protozoan (GO:0001562)2.53048405
197dendritic cell chemotaxis (GO:0002407)2.51938507
198positive T cell selection (GO:0043368)2.50385236
199regulation of antigen processing and presentation (GO:0002577)2.50292758
200regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47305739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.36638446
2* IRF8_22096565_ChIP-ChIP_GC-B_Human6.32756168
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.65491116
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.64586596
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94147128
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.85771005
7CLOCK_20551151_ChIP-Seq_293T_Human3.71848460
8* SMAD_19615063_ChIP-ChIP_OVARY_Human2.89939637
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.89556997
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86601954
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83516264
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.81847098
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.74441907
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.72749896
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58662675
16RUNX_20019798_ChIP-Seq_JUKART_Human2.58403299
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55512035
18* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.47241474
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38446155
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24411833
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24194970
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12314920
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08738694
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.08308119
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05165653
26GATA1_22025678_ChIP-Seq_K562_Human2.04486162
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse13.5754364
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97441333
29MYB_26560356_Chip-Seq_TH2_Human1.96625257
30PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.94874271
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.94181385
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91158619
33* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77666181
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73751896
35SCL_19346495_ChIP-Seq_HPC-7_Human1.73021196
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.64835496
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63974011
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63722146
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62853589
40SPI1_23127762_ChIP-Seq_K562_Human1.60328945
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58861129
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58857136
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57951425
44MYB_26560356_Chip-Seq_TH1_Human1.56635745
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55870475
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54781084
47GATA3_27048872_Chip-Seq_THYMUS_Human1.49956065
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.48876628
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44383979
50GATA3_26560356_Chip-Seq_TH2_Human1.43429181
51* SOX2_20726797_ChIP-Seq_SW620_Human1.42919500
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34943494
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34252618
54ZNF263_19887448_ChIP-Seq_K562_Human1.33364712
55SPI1_23547873_ChIP-Seq_NB4_Human1.33276907
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33118847
57VDR_24763502_ChIP-Seq_THP-1_Human1.31072644
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28692303
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28519171
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.26827940
61CJUN_26792858_Chip-Seq_BT549_Human1.23364444
62* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22771353
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22536791
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22405302
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22152525
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.22147364
67MAF_26560356_Chip-Seq_TH1_Human1.21388326
68* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18904996
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17722620
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.15956283
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14068204
72* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13779307
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13548950
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10908527
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10083426
76PU_27001747_Chip-Seq_BMDM_Mouse1.09874485
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09057157
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.07871519
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.07871519
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.05286461
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.04068896
82GATA1_19941826_ChIP-Seq_K562_Human1.02452136
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.02416775
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.02256544
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02150771
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00358561
87RACK7_27058665_Chip-Seq_MCF-7_Human0.99346242
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99045236
89SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97486048
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97178365
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95854443
92VDR_24787735_ChIP-Seq_THP-1_Human0.95703191
93ESR1_21235772_ChIP-Seq_MCF-7_Human0.95609888
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95541197
95* SMRT_27268052_Chip-Seq_Bcells_Human0.94937278
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94453519
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94412887
98RXR_22108803_ChIP-Seq_LS180_Human0.94192325
99TP53_16413492_ChIP-PET_HCT116_Human0.93026059
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92435447
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91554801
102* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91340026
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.90171631
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87801200
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87575660
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85754993
107UTX_26944678_Chip-Seq_JUKART_Human0.85740409
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.84777207
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.84031219
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83901228
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83698858
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82989987
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82644238
114TP63_23658742_ChIP-Seq_EP156T_Human0.82618357
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82607026
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82489982
117AHR_22903824_ChIP-Seq_MCF-7_Human0.82239159
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81964363
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.81770103
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.80970261
121* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80803519
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.80627967
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80523100
124* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79990860
125* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79923832
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79632438
127CDX2_22108803_ChIP-Seq_LS180_Human0.79554877
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.79525114
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78400296
130* PRDM14_20953172_ChIP-Seq_ESCs_Human0.77012588
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77012402
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76959890
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76562290
134* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76446142
135* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76446142
136CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76425067
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76075436
138OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75722643
139EZH2_18974828_ChIP-Seq_MESCs_Mouse0.75138947
140RNF2_18974828_ChIP-Seq_MESCs_Mouse0.75138947
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74705672
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74609419
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.74097039
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.73907435
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73721505
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73472594
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73465810
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.73229794
149JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72761370
150* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72687452
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.72436258
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71835007
153ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70612130
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.70337286
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69110811
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68208693
157BCAT_22108803_ChIP-Seq_LS180_Human0.67288800
158SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67138885
159CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64173495
160TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.62182413
161RUNX1_27514584_Chip-Seq_MCF-7_Human0.61976524
162ISL1_27105846_Chip-Seq_CPCs_Mouse0.60411588
163PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60341888
164GATA2_19941826_ChIP-Seq_K562_Human0.59259293
165SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.58797088
166NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58386140
167GATA3_21878914_ChIP-Seq_MCF-7_Human0.57223507
168SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56842897
169FOXM1_26456572_ChIP-Seq_MCF-7_Human0.56471159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.37165131
2MP0005666_abnormal_adipose_tissue5.37017886
3MP0004130_abnormal_muscle_cell4.97579690
4MP0004185_abnormal_adipocyte_glucose4.51014840
5MP0008438_abnormal_cutaneous_collagen4.31934698
6MP0005375_adipose_tissue_phenotype4.05235305
7MP0001835_abnormal_antigen_presentation3.66686741
8MP0002876_abnormal_thyroid_physiology3.59966671
9MP0003303_peritoneal_inflammation3.24464063
10MP0002971_abnormal_brown_adipose3.15867942
11MP0000013_abnormal_adipose_tissue3.08393124
12MP0009115_abnormal_fat_cell2.97469353
13MP0003436_decreased_susceptibility_to2.95948737
14MP0006082_CNS_inflammation2.94425123
15MP0002837_dystrophic_cardiac_calcinosis2.94126794
16MP0009785_altered_susceptibility_to2.92040764
17MP0005275_abnormal_skin_tensile2.91489809
18MP0000003_abnormal_adipose_tissue2.86965953
19MP0001790_abnormal_immune_system2.67415826
20MP0005387_immune_system_phenotype2.67415826
21MP0005671_abnormal_response_to2.65611375
22MP0001800_abnormal_humoral_immune2.63423409
23MP0005334_abnormal_fat_pad2.55241017
24MP0003300_gastrointestinal_ulcer2.52984251
25MP0005025_abnormal_response_to2.49228234
26MP0005000_abnormal_immune_tolerance2.44114558
27MP0002419_abnormal_innate_immunity2.37899781
28MP0010329_abnormal_lipoprotein_level2.35343449
29MP0002148_abnormal_hypersensitivity_rea2.34001536
30MP0002723_abnormal_immune_serum2.24668021
31MP0003763_abnormal_thymus_physiology2.23353026
32MP0002452_abnormal_antigen_presenting2.19991937
33MP0003191_abnormal_cellular_cholesterol2.17070706
34MP0010155_abnormal_intestine_physiology2.13085309
35MP0002970_abnormal_white_adipose2.07732091
36MP0002139_abnormal_hepatobiliary_system2.03356561
37MP0002420_abnormal_adaptive_immunity1.98614980
38MP0001819_abnormal_immune_cell1.98034544
39MP0010234_abnormal_vibrissa_follicle1.97211916
40MP0003959_abnormal_lean_body1.92601470
41MP0002138_abnormal_hepatobiliary_system1.81842486
42MP0002118_abnormal_lipid_homeostasis1.80104673
43MP0001845_abnormal_inflammatory_respons1.74948398
44MP0005310_abnormal_salivary_gland1.74665317
45MP0000569_abnormal_digit_pigmentation1.74339659
46MP0004947_skin_inflammation1.69584701
47MP0009764_decreased_sensitivity_to1.68157144
48MP0002405_respiratory_system_inflammati1.65770656
49MP0005535_abnormal_body_temperature1.62759130
50MP0003195_calcinosis1.59935662
51MP0002009_preneoplasia1.58344883
52MP0003183_abnormal_peptide_metabolism1.52965248
53MP0000716_abnormal_immune_system1.51020357
54MP0003724_increased_susceptibility_to1.50786380
55MP0003705_abnormal_hypodermis_morpholog1.50603363
56MP0008469_abnormal_protein_level1.49165605
57MP0003866_abnormal_defecation1.48499557
58MP0003828_pulmonary_edema1.47125327
59MP0002060_abnormal_skin_morphology1.46661180
60MP0009333_abnormal_splenocyte_physiolog1.44263131
61MP0001661_extended_life_span1.41323031
62MP0005464_abnormal_platelet_physiology1.40387235
63MP0005448_abnormal_energy_balance1.40106985
64MP0003186_abnormal_redox_activity1.39509285
65MP0002398_abnormal_bone_marrow1.39436397
66MP0003690_abnormal_glial_cell1.37646869
67MP0005451_abnormal_body_composition1.37075602
68MP0004272_abnormal_basement_membrane1.35499033
69MP0004883_abnormal_blood_vessel1.35461054
70MP0005452_abnormal_adipose_tissue1.34216539
71MP0001873_stomach_inflammation1.32269774
72MP0005360_urolithiasis1.31931422
73MP0005379_endocrine/exocrine_gland_phen1.29128739
74MP0000751_myopathy1.28712177
75MP0005085_abnormal_gallbladder_physiolo1.24269792
76MP0002166_altered_tumor_susceptibility1.23243138
77MP0000689_abnormal_spleen_morphology1.21098652
78MP0000465_gastrointestinal_hemorrhage1.20976400
79MP0001851_eye_inflammation1.20360451
80MP0002796_impaired_skin_barrier1.19835856
81MP0001501_abnormal_sleep_pattern1.19385204
82MP0003045_fibrosis1.19089813
83MP0003252_abnormal_bile_duct1.18939111
84MP0004510_myositis1.15236427
85MP0002078_abnormal_glucose_homeostasis1.14150721
86MP0002722_abnormal_immune_system1.13984497
87MP0003172_abnormal_lysosome_physiology1.13903793
88MP0005166_decreased_susceptibility_to1.13809522
89MP0001881_abnormal_mammary_gland1.12503587
90MP0009840_abnormal_foam_cell1.11666949
91MP0002429_abnormal_blood_cell1.10533509
92MP0005645_abnormal_hypothalamus_physiol1.08422901
93MP0006054_spinal_hemorrhage1.07716405
94MP0000604_amyloidosis1.07597688
95MP0008260_abnormal_autophagy1.05011593
96MP0008004_abnormal_stomach_pH1.04879075
97MP0000343_altered_response_to1.03116603
98MP0003448_altered_tumor_morphology1.03037014
99MP0000750_abnormal_muscle_regeneration1.02946235
100MP0003656_abnormal_erythrocyte_physiolo1.02930658
101MP0003075_altered_response_to1.02739052
102MP0004147_increased_porphyrin_level1.00357607
103MP0003646_muscle_fatigue0.97531372
104MP0000609_abnormal_liver_physiology0.97269747
105MP0009763_increased_sensitivity_to0.97050090
106MP0005620_abnormal_muscle_contractility0.96806136
107MP0002006_tumorigenesis0.95976198
108MP0000759_abnormal_skeletal_muscle0.95818708
109MP0004381_abnormal_hair_follicle0.94610137
110MP0002933_joint_inflammation0.92315197
111MP0000703_abnormal_thymus_morphology0.91113706
112MP0001663_abnormal_digestive_system0.91017803
113MP0000249_abnormal_blood_vessel0.90645841
114MP0006138_congestive_heart_failure0.89022820
115MP0002108_abnormal_muscle_morphology0.87556995
116MP0003950_abnormal_plasma_membrane0.87155226
117MP0001853_heart_inflammation0.85877428
118MP0001727_abnormal_embryo_implantation0.85462459
119MP0004087_abnormal_muscle_fiber0.83993880
120MP0003091_abnormal_cell_migration0.83984889
121MP0003806_abnormal_nucleotide_metabolis0.81615736
122MP0003566_abnormal_cell_adhesion0.81525072
123MP0002277_abnormal_respiratory_mucosa0.80998876
124MP0002332_abnormal_exercise_endurance0.80713197
125MP0005164_abnormal_response_to0.79896759
126MP0008775_abnormal_heart_ventricle0.78802424
127MP0003868_abnormal_feces_composition0.77102293
128MP0003948_abnormal_gas_homeostasis0.76113632
129MP0002254_reproductive_system_inflammat0.75091473
130MP0002132_abnormal_respiratory_system0.73514796
131MP0002909_abnormal_adrenal_gland0.73510609
132MP0005171_absent_coat_pigmentation0.73435904
133MP0002295_abnormal_pulmonary_circulatio0.73431872
134MP0003953_abnormal_hormone_level0.73035589
135MP0004134_abnormal_chest_morphology0.72997874
136MP0005376_homeostasis/metabolism_phenot0.72474254
137MP0002638_abnormal_pupillary_reflex0.70227025
138MP0000749_muscle_degeneration0.69445337
139MP0009780_abnormal_chondrocyte_physiolo0.68777343
140MP0001764_abnormal_homeostasis0.65413608
141MP0005385_cardiovascular_system_phenoty0.63079344
142MP0001544_abnormal_cardiovascular_syste0.63079344
143MP0001756_abnormal_urination0.62628874
144MP0006036_abnormal_mitochondrial_physio0.62087626
145MP0005058_abnormal_lysosome_morphology0.60821676
146MP0005365_abnormal_bile_salt0.60302448
147MP0004782_abnormal_surfactant_physiolog0.60168817
148MP0002168_other_aberrant_phenotype0.59730877
149MP0000681_abnormal_thyroid_gland0.58867142
150MP0000858_altered_metastatic_potential0.57959876
151MP0002249_abnormal_larynx_morphology0.56279314
152MP0005647_abnormal_sex_gland0.55166133
153MP0005330_cardiomyopathy0.54597203
154MP0003279_aneurysm0.53482170
155MP0001177_atelectasis0.53441383
156MP0000685_abnormal_immune_system0.53329061
157MP0005397_hematopoietic_system_phenotyp0.53063550
158MP0001545_abnormal_hematopoietic_system0.53063550
159MP0005319_abnormal_enzyme/_coenzyme0.52522071
160MP0000163_abnormal_cartilage_morphology0.52510436
161MP0002998_abnormal_bone_remodeling0.49739941
162MP0000627_abnormal_mammary_gland0.48359009
163MP0005369_muscle_phenotype0.48278375
164MP0002106_abnormal_muscle_physiology0.48110584
165MP0001533_abnormal_skeleton_physiology0.46289217
166MP0005388_respiratory_system_phenotype0.46022753
167MP0002133_abnormal_respiratory_system0.46022753
168MP0005076_abnormal_cell_differentiation0.45762442
169MP0001879_abnormal_lymphatic_vessel0.45675546
170MP0005584_abnormal_enzyme/coenzyme_acti0.44269722

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)8.77736847
2Acanthosis nigricans (HP:0000956)7.19472557
3Hypertriglyceridemia (HP:0002155)5.80599091
4Eczematoid dermatitis (HP:0000976)5.16057891
5Optic neuritis (HP:0100653)5.15147336
6Retrobulbar optic neuritis (HP:0100654)5.15147336
7Orchitis (HP:0100796)5.10143565
8Hyperglycinuria (HP:0003108)5.04215041
9Myositis (HP:0100614)4.93036528
10Difficulty running (HP:0009046)4.86105471
11Insulin-resistant diabetes mellitus (HP:0000831)4.61457540
12Type 1 muscle fiber predominance (HP:0003803)4.60424006
13Myoglobinuria (HP:0002913)4.55014776
14Recurrent bacterial skin infections (HP:0005406)4.54927503
15Long foot (HP:0001833)4.39446824
16Increased connective tissue (HP:0009025)4.35449590
17Recurrent abscess formation (HP:0002722)4.30013108
18Growth hormone excess (HP:0000845)4.26038321
19Abnormality of T cell number (HP:0011839)4.24649569
20T lymphocytopenia (HP:0005403)4.16243341
21Elevated erythrocyte sedimentation rate (HP:0003565)3.86265344
22Stomatitis (HP:0010280)3.82384715
23Abnormality of macrophages (HP:0004311)3.81221158
24Keratoconjunctivitis sicca (HP:0001097)3.80855485
25Gastrointestinal infarctions (HP:0005244)3.78496815
26Recurrent gram-negative bacterial infections (HP:0005420)3.75648660
27Recurrent fungal infections (HP:0002841)3.70503971
28Keratoconjunctivitis (HP:0001096)3.65527535
29Abnormality of serine family amino acid metabolism (HP:0010894)3.64183790
30Abnormality of glycine metabolism (HP:0010895)3.64183790
31Rhabdomyolysis (HP:0003201)3.60910235
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.57446825
33Vasculitis (HP:0002633)3.43000386
34Thyroid-stimulating hormone excess (HP:0002925)3.42675388
35Hemoptysis (HP:0002105)3.25905287
36Pigmentary retinal degeneration (HP:0001146)3.25048374
37Chronic mucocutaneous candidiasis (HP:0002728)3.24837048
38Recurrent cutaneous fungal infections (HP:0011370)3.24837048
39Recurrent skin infections (HP:0001581)3.24794233
40Pulmonary infiltrates (HP:0002113)3.24643937
41Abnormality of fatty-acid metabolism (HP:0004359)3.24360281
42Gingivitis (HP:0000230)3.23135487
43Mediastinal lymphadenopathy (HP:0100721)3.22330464
44Autoimmune hemolytic anemia (HP:0001890)3.21670273
45Complement deficiency (HP:0004431)3.17332652
46Insulin resistance (HP:0000855)3.15797152
47Hydroxyprolinuria (HP:0003080)3.13638051
48Abnormality of proline metabolism (HP:0010907)3.13638051
49Facial diplegia (HP:0001349)3.11422003
50Spontaneous hematomas (HP:0007420)3.07800764
51Exercise-induced myalgia (HP:0003738)3.06032484
52Encephalitis (HP:0002383)3.05648626
53Hyperpituitarism (HP:0010514)3.05321279
54Meningitis (HP:0001287)3.03846655
55Recurrent viral infections (HP:0004429)2.98955568
56Recurrent bronchitis (HP:0002837)2.98772385
57Bone cyst (HP:0012062)2.98301556
58Hyperthyroidism (HP:0000836)2.96289905
59Autoimmune thrombocytopenia (HP:0001973)2.94531750
60Reduced subcutaneous adipose tissue (HP:0003758)2.93850790
61Subcapsular cataract (HP:0000523)2.91826907
62Neck muscle weakness (HP:0000467)2.90776425
63Arterial thrombosis (HP:0004420)2.89247711
64Muscle stiffness (HP:0003552)2.89122700
65Gingival bleeding (HP:0000225)2.88976766
66Spinal rigidity (HP:0003306)2.88392197
67Abnormality of T cells (HP:0002843)2.87493327
68Muscle fiber splitting (HP:0003555)2.86299543
69Muscle fiber inclusion bodies (HP:0100299)2.82417125
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.80916184
71Leukocytosis (HP:0001974)2.80405797
72Aortic dissection (HP:0002647)2.75685421
73Aortic aneurysm (HP:0004942)2.75595092
74Increased variability in muscle fiber diameter (HP:0003557)2.73503726
75Ileus (HP:0002595)2.72620399
76Right ventricular cardiomyopathy (HP:0011663)2.72133706
77Pulmonary embolism (HP:0002204)2.71757978
78Nemaline bodies (HP:0003798)2.68533242
79Chronic diarrhea (HP:0002028)2.68514482
80Hemorrhage of the eye (HP:0011885)2.67031008
81Increased muscle lipid content (HP:0009058)2.65153947
82Malnutrition (HP:0004395)2.65122890
83Hematochezia (HP:0002573)2.65002455
84Peritonitis (HP:0002586)2.61011718
85Gangrene (HP:0100758)2.59321122
86Eosinophilia (HP:0001880)2.59181050
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.57241413
88Broad metatarsal (HP:0001783)2.55983552
89Pustule (HP:0200039)2.55970197
90Abnormality of skeletal muscle fiber size (HP:0012084)2.54151315
91Accelerated skeletal maturation (HP:0005616)2.53311407
92Colitis (HP:0002583)2.52479607
93Follicular hyperkeratosis (HP:0007502)2.50272692
94Large hands (HP:0001176)2.49641986
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48006774
96Inflammation of the large intestine (HP:0002037)2.46940833
97Pancreatitis (HP:0001733)2.46506471
98Myocardial infarction (HP:0001658)2.45813078
99Anorexia (HP:0002039)2.43319349
100Hypoalphalipoproteinemia (HP:0003233)2.43111806
101Lipoatrophy (HP:0100578)2.42662139
102Abnormality of complement system (HP:0005339)2.40107320
103Increased IgM level (HP:0003496)2.39198663
104Ketoacidosis (HP:0001993)2.38433335
105Abnormal hemoglobin (HP:0011902)2.36868280
106Chest pain (HP:0100749)2.36387722
107Granulocytopenia (HP:0001913)2.36124370
108Cerebral aneurysm (HP:0004944)2.35003707
109Testicular atrophy (HP:0000029)2.34981355
110Shawl scrotum (HP:0000049)2.34144486
111Chronic otitis media (HP:0000389)2.31125874
112Obstructive lung disease (HP:0006536)2.31068892
113Chronic obstructive pulmonary disease (HP:0006510)2.31068892
114Urticaria (HP:0001025)2.29894369
115Epistaxis (HP:0000421)2.27744556
116Hypoglycemic coma (HP:0001325)2.27429984
117Congenital, generalized hypertrichosis (HP:0004540)2.27293959
118Proximal amyotrophy (HP:0007126)2.27080710
119Abnormality of eosinophils (HP:0001879)2.26599523
120Abnormality of the pleura (HP:0002103)2.25874218
121Stomach cancer (HP:0012126)2.25848510
122Prolonged bleeding time (HP:0003010)2.24417295
123Increased IgE level (HP:0003212)2.24374526
124Bulbar palsy (HP:0001283)2.23809501
125Increased cerebral lipofuscin (HP:0011813)2.22943895
126Gastrointestinal inflammation (HP:0004386)2.22061815
127Myotonia (HP:0002486)2.21814105
128Abnormality of T cell physiology (HP:0011840)2.20899402
129Abnormality of B cell number (HP:0010975)2.19911912
130Joint swelling (HP:0001386)2.19003062
131Dicarboxylic aciduria (HP:0003215)2.17639570
132Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17639570
133Prenatal maternal abnormality (HP:0002686)2.16981341
134Turricephaly (HP:0000262)2.16215952
135Glomerulonephritis (HP:0000099)2.13648467
136Prominent supraorbital ridges (HP:0000336)2.12248162
137Alopecia of scalp (HP:0002293)2.09238975
138Thyroiditis (HP:0100646)2.09106343
139Hyporeflexia of lower limbs (HP:0002600)2.08860554
140Abnormality of glycolipid metabolism (HP:0010969)2.08645526
141Abnormality of liposaccharide metabolism (HP:0010968)2.08645526
142Abnormality of glycosphingolipid metabolism (HP:0004343)2.08645526
143Abnormality of the pericardium (HP:0001697)2.07862727
144Amyloidosis (HP:0011034)2.07233751
145Interstitial pulmonary disease (HP:0006530)2.07229052
146Hypergammaglobulinemia (HP:0010702)2.06702137
147Rectal prolapse (HP:0002035)2.06078994
148Neoplasm of the tracheobronchial system (HP:0100552)2.05829573
149Acute hepatic failure (HP:0006554)2.05577337
150Gastrointestinal dysmotility (HP:0002579)2.04210925
151Slender build (HP:0001533)2.03113586
152Increased neuronal autofluorescent lipopigment (HP:0002074)2.02690747
153Flat acetabular roof (HP:0003180)2.00625892
154Ketosis (HP:0001946)1.99978305
155Scapular winging (HP:0003691)1.99442996
156Loss of speech (HP:0002371)1.99409705
157Duplicated collecting system (HP:0000081)1.99272341
158Nausea (HP:0002018)1.98823905
159Stridor (HP:0010307)1.98720156
160Alveolar cell carcinoma (HP:0006519)1.98088168
161Myopathic facies (HP:0002058)1.97201088
162Osteomyelitis (HP:0002754)1.97041522
163Mildly elevated creatine phosphokinase (HP:0008180)1.96895597
164Acne (HP:0001061)1.96580145
165Tetraparesis (HP:0002273)1.95972176
166Ankle contracture (HP:0006466)1.93177134
167Epidermoid cyst (HP:0200040)1.92932897
168Dysostosis multiplex (HP:0000943)1.92714733
169Panhypogammaglobulinemia (HP:0003139)1.92257875
170Vertigo (HP:0002321)1.92147722
171Episodic fever (HP:0001954)1.92102399
172Abnormality of the endocardium (HP:0004306)1.92076328
173Hypochromic anemia (HP:0001931)1.91816361
174Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91557754
175Decreased subcutaneous fat (HP:0001002)1.91241267
176Fibular hypoplasia (HP:0003038)1.90477246
177Round ear (HP:0100830)1.89207278
178Toxemia of pregnancy (HP:0100603)1.88237675
179Increased CSF protein (HP:0002922)1.88167882
180Cellulitis (HP:0100658)1.87476181
181Glomerulopathy (HP:0100820)1.87060515
182Nephritis (HP:0000123)1.86987266
183Polyneuropathy (HP:0001271)1.86657305
184Thrombophlebitis (HP:0004418)1.86211934
185Neonatal hypoglycemia (HP:0001998)1.86060446
186Premature rupture of membranes (HP:0001788)1.84328060
187Gowers sign (HP:0003391)1.83162552
188Easy fatigability (HP:0003388)1.80993072
189Hypercortisolism (HP:0001578)1.77144608
190Abnormality of the axillary hair (HP:0100134)1.74664556
191Abnormality of secondary sexual hair (HP:0009888)1.74664556
192Abnormal eating behavior (HP:0100738)1.73628551
193Clitoromegaly (HP:0000057)1.73528064
194Hypoplastic ischia (HP:0003175)1.73516406
195Systemic lupus erythematosus (HP:0002725)1.71898467
196Hyperglycemia (HP:0003074)1.69582621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D5.29970690
2BCKDK3.81509631
3CAMK1G3.81501366
4TRIB33.78597785
5AKT33.57548757
6TYK23.48987027
7SIK13.46826146
8PIK3CA3.25771531
9RIPK42.97083289
10LMTK22.90003421
11MAP4K12.84696962
12TXK2.82262501
13BLK2.59905512
14IKBKE2.57296506
15MYLK2.53860621
16PDK22.50707171
17MAP3K62.32993762
18ACVR1B2.27331133
19MAP3K142.25219469
20DDR22.23745212
21EPHB22.17967359
22FGFR42.06920994
23MST1R2.05091131
24IRAK42.02091665
25OBSCN1.97231571
26PDK31.95291733
27PDK41.95291733
28INSRR1.76883817
29ZAP701.75744979
30IRAK31.75194308
31KIT1.74293713
32PRKAA21.72473215
33TBK11.60280440
34IRAK11.58624229
35PINK11.56552655
36BTK1.55289081
37MAPK151.50707856
38NLK1.49981994
39EPHB11.47890489
40EPHA31.45944969
41FES1.45418922
42SYK1.42804757
43BMPR21.39657379
44PHKG21.36888306
45PHKG11.36888306
46GRK71.35857789
47MAP3K131.35529652
48LATS11.34855618
49IKBKB1.33837324
50TEC1.32502130
51RIPK11.32422934
52ICK1.32376094
53ITK1.31782686
54TNK21.30493409
55GRK61.30121717
56PRKD21.28521405
57HCK1.24889812
58TTN1.24556247
59FRK1.24463657
60CDK61.24328582
61PDGFRA1.21346016
62LCK1.16199755
63LYN1.13532823
64TRPM71.13495471
65CDK91.09418113
66PIK3CG1.07858627
67TIE11.05995377
68MAP3K21.05765260
69CAMKK21.03961694
70PRKAA11.01732041
71CSK0.99412340
72MAP3K10.97693058
73GSK3A0.97204290
74BMX0.96351398
75FGFR30.93746579
76ADRBK20.87063580
77HIPK20.81893066
78CHUK0.77255735
79MARK30.74000289
80JAK10.71867671
81PRKCH0.71569689
82ERN10.71360515
83PDPK10.71253565
84MELK0.70944186
85PRKG20.69861787
86MAPK110.68655738
87YES10.68215391
88STK100.68022431
89MAP3K70.66463024
90DMPK0.64117745
91TAOK10.64054520
92MET0.63305851
93EIF2AK20.63151156
94FGFR20.62556113
95PAK20.62208852
96MAP2K60.61539994
97TAOK30.61530273
98SGK20.61527425
99TGFBR20.59029254
100PIM10.58475063
101FER0.58398609
102PRKCQ0.56527708
103FGR0.53745154
104MAP2K10.52839080
105STK240.52481698
106MARK20.52145185
107IRAK20.50601615
108PRKACG0.48851625
109STK380.48550856
110MAPK120.47934693
111RPS6KB10.46938604
112MTOR0.46673650
113JAK20.46408187
114STK30.46204128
115TAOK20.44509680
116PTK2B0.44042252
117PDGFRB0.43314646
118MATK0.42966327
119INSR0.41296021
120PIM20.40304535
121SIK30.39781932
122PDK10.39412379
123WNK10.39106575
124RET0.39069407
125RPS6KC10.38912663
126RPS6KL10.38912663
127LATS20.38898883
128NEK90.38476006
129MAP3K110.37575509
130JAK30.37357393
131PRKD10.37250320
132ADRBK10.36982681
133FYN0.36899109
134MAP3K50.36093690
135PRPF4B0.35669395
136IGF1R0.35651937
137EGFR0.35051739
138SGK30.34754249
139ABL20.34321681
140GRK50.33916725
141MAPK70.33265481
142ZAK0.32751932
143RPS6KA60.32647415
144CDC42BPA0.32310645
145FGFR10.31886001
146MAPK40.30651782
147MAP3K30.28588448
148CAMK10.28478041
149PRKD30.27219450
150MAPKAPK20.27069815
151SRC0.26830065
152CAMK2G0.25372708
153ABL10.25249883
154CSF1R0.24701592
155CAMK2D0.23779148
156MAPK30.23105508
157TTK0.23012041
158MAP2K30.22409059
159NEK60.21942785

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.73309205
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.62751966
3Propanoate metabolism_Homo sapiens_hsa006404.54865139
4PPAR signaling pathway_Homo sapiens_hsa033204.45633362
5Fatty acid metabolism_Homo sapiens_hsa012123.64845128
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.32789308
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.03272112
8Glycerolipid metabolism_Homo sapiens_hsa005612.87803435
9Fatty acid degradation_Homo sapiens_hsa000712.59621263
10Graft-versus-host disease_Homo sapiens_hsa053322.57976771
11Allograft rejection_Homo sapiens_hsa053302.57557491
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50775792
13Leishmaniasis_Homo sapiens_hsa051402.42832558
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29720795
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26989425
16Osteoclast differentiation_Homo sapiens_hsa043802.23941887
17beta-Alanine metabolism_Homo sapiens_hsa004102.22193511
18AMPK signaling pathway_Homo sapiens_hsa041522.13764676
19Adipocytokine signaling pathway_Homo sapiens_hsa049202.13502192
20Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01478338
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.95811685
22Pyruvate metabolism_Homo sapiens_hsa006201.93277206
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88255600
24Type I diabetes mellitus_Homo sapiens_hsa049401.85115669
25Asthma_Homo sapiens_hsa053101.83257667
26Measles_Homo sapiens_hsa051621.81493226
27Sulfur metabolism_Homo sapiens_hsa009201.80523874
28Primary immunodeficiency_Homo sapiens_hsa053401.73031517
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70685089
30Influenza A_Homo sapiens_hsa051641.65425691
31Tuberculosis_Homo sapiens_hsa051521.63377093
32Fat digestion and absorption_Homo sapiens_hsa049751.60714895
33Phenylalanine metabolism_Homo sapiens_hsa003601.59340512
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58025775
35B cell receptor signaling pathway_Homo sapiens_hsa046621.56784922
36TNF signaling pathway_Homo sapiens_hsa046681.55736849
37Toxoplasmosis_Homo sapiens_hsa051451.50089286
38Hematopoietic cell lineage_Homo sapiens_hsa046401.43194826
39Antigen processing and presentation_Homo sapiens_hsa046121.42601852
40T cell receptor signaling pathway_Homo sapiens_hsa046601.38151601
41Vitamin B6 metabolism_Homo sapiens_hsa007501.33856529
42Pertussis_Homo sapiens_hsa051331.33334469
43Peroxisome_Homo sapiens_hsa041461.33081188
44Hepatitis C_Homo sapiens_hsa051601.32276636
45African trypanosomiasis_Homo sapiens_hsa051431.29836439
46Fatty acid elongation_Homo sapiens_hsa000621.29341235
47Complement and coagulation cascades_Homo sapiens_hsa046101.28248161
48Herpes simplex infection_Homo sapiens_hsa051681.25457452
49Chemokine signaling pathway_Homo sapiens_hsa040621.25157214
50Insulin signaling pathway_Homo sapiens_hsa049101.24069501
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21363204
52Tyrosine metabolism_Homo sapiens_hsa003501.19039989
53Carbon metabolism_Homo sapiens_hsa012001.17632730
54Insulin resistance_Homo sapiens_hsa049311.14620901
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11983950
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10888767
57Legionellosis_Homo sapiens_hsa051341.09065069
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08732989
59Caffeine metabolism_Homo sapiens_hsa002321.08669358
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08332967
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08157806
62Rheumatoid arthritis_Homo sapiens_hsa053231.08080446
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06450071
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04793018
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04220645
66Butanoate metabolism_Homo sapiens_hsa006501.00071037
67Dorso-ventral axis formation_Homo sapiens_hsa043200.98809892
68Hepatitis B_Homo sapiens_hsa051610.96229417
69Prolactin signaling pathway_Homo sapiens_hsa049170.95558467
70Staphylococcus aureus infection_Homo sapiens_hsa051500.94808358
71Other glycan degradation_Homo sapiens_hsa005110.94397185
72ECM-receptor interaction_Homo sapiens_hsa045120.93031571
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92528742
74Glucagon signaling pathway_Homo sapiens_hsa049220.90569423
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.89339692
76Arachidonic acid metabolism_Homo sapiens_hsa005900.87834909
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.87796642
78Fructose and mannose metabolism_Homo sapiens_hsa000510.86916117
79Renin secretion_Homo sapiens_hsa049240.83880319
80Platelet activation_Homo sapiens_hsa046110.83376397
81Histidine metabolism_Homo sapiens_hsa003400.83144440
82Autoimmune thyroid disease_Homo sapiens_hsa053200.81239263
83Linoleic acid metabolism_Homo sapiens_hsa005910.80101468
84Phagosome_Homo sapiens_hsa041450.78520159
85Sulfur relay system_Homo sapiens_hsa041220.76227698
86Retinol metabolism_Homo sapiens_hsa008300.75596262
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74832226
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.72492386
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.70593108
90Chemical carcinogenesis_Homo sapiens_hsa052040.69156855
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.68225758
92Renin-angiotensin system_Homo sapiens_hsa046140.67126495
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65814233
94Apoptosis_Homo sapiens_hsa042100.65534893
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65148407
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64231224
97FoxO signaling pathway_Homo sapiens_hsa040680.64013619
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63529368
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62286223
100Pancreatic cancer_Homo sapiens_hsa052120.61392597
101Protein digestion and absorption_Homo sapiens_hsa049740.60218440
102ABC transporters_Homo sapiens_hsa020100.56977302
103Focal adhesion_Homo sapiens_hsa045100.56073077
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.55756752
105Non-small cell lung cancer_Homo sapiens_hsa052230.54049904
106HIF-1 signaling pathway_Homo sapiens_hsa040660.50155793
107Starch and sucrose metabolism_Homo sapiens_hsa005000.47787034
108Pentose phosphate pathway_Homo sapiens_hsa000300.46594142
109Adherens junction_Homo sapiens_hsa045200.45726855
110Salmonella infection_Homo sapiens_hsa051320.44957044
111VEGF signaling pathway_Homo sapiens_hsa043700.44719861
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44357796
113Acute myeloid leukemia_Homo sapiens_hsa052210.43811471
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43536474
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40452726
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.39991699
117Tryptophan metabolism_Homo sapiens_hsa003800.39125999
118Chronic myeloid leukemia_Homo sapiens_hsa052200.37157625
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36884656
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.36730510
121Lysosome_Homo sapiens_hsa041420.36610642
122Renal cell carcinoma_Homo sapiens_hsa052110.35130208
123Circadian rhythm_Homo sapiens_hsa047100.34804142
124Type II diabetes mellitus_Homo sapiens_hsa049300.34148406
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33646767
126Viral myocarditis_Homo sapiens_hsa054160.33569074
127Tight junction_Homo sapiens_hsa045300.33076938
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32014307
129TGF-beta signaling pathway_Homo sapiens_hsa043500.31484721
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.31400019
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30269811
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.29298185
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.27844334
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27612632
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.25340464
136cAMP signaling pathway_Homo sapiens_hsa040240.25172226
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24813647
138Metabolic pathways_Homo sapiens_hsa011000.24740674
139Lysine degradation_Homo sapiens_hsa003100.23832013
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23704324
141Oxidative phosphorylation_Homo sapiens_hsa001900.23257054
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22982456
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22479215
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21673303
145mTOR signaling pathway_Homo sapiens_hsa041500.19820940
146Basal cell carcinoma_Homo sapiens_hsa052170.18764351
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17902352
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17508118
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17037287
150Melanoma_Homo sapiens_hsa052180.16394901
151Ovarian steroidogenesis_Homo sapiens_hsa049130.16086701
152Salivary secretion_Homo sapiens_hsa049700.15389389
153Galactose metabolism_Homo sapiens_hsa000520.15126785
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13942317
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13930601
156Small cell lung cancer_Homo sapiens_hsa052220.13849137
157Biosynthesis of amino acids_Homo sapiens_hsa012300.13586856
158Hippo signaling pathway_Homo sapiens_hsa043900.12972189
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.12948542
160Alzheimers disease_Homo sapiens_hsa050100.12863089
161Proteoglycans in cancer_Homo sapiens_hsa052050.12450044
162Malaria_Homo sapiens_hsa051440.12426235
163Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11455359
164Parkinsons disease_Homo sapiens_hsa050120.11429898
165Dilated cardiomyopathy_Homo sapiens_hsa054140.10736185
166Glutathione metabolism_Homo sapiens_hsa004800.09906075
167Amoebiasis_Homo sapiens_hsa051460.09899745
168Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09851427

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