APOLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)9.54535412
2vascular endothelial growth factor signaling pathway (GO:0038084)8.35183542
3positive regulation of vasculogenesis (GO:2001214)8.05234700
4positive regulation of chemokine secretion (GO:0090197)7.69549601
5regulation of chemokine secretion (GO:0090196)6.43981169
6ovulation from ovarian follicle (GO:0001542)6.32267449
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.25796405
8positive regulation of macrophage activation (GO:0043032)6.25258057
9regulation of vasculogenesis (GO:2001212)6.15321193
10glomerular filtration (GO:0003094)6.14632663
11lymphangiogenesis (GO:0001946)6.07186521
12blood vessel maturation (GO:0001955)5.72015605
13retina vasculature morphogenesis in camera-type eye (GO:0061299)5.65138842
14peptidyl-tyrosine autophosphorylation (GO:0038083)5.63484027
15sprouting angiogenesis (GO:0002040)5.57072372
16negative regulation of blood vessel endothelial cell migration (GO:0043537)5.51594636
17renal filtration (GO:0097205)5.50109900
18vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.42299070
19negative regulation of macrophage differentiation (GO:0045650)5.36578313
20endothelial cell morphogenesis (GO:0001886)5.33428527
21regulation of gonadotropin secretion (GO:0032276)5.25905003
22negative regulation of endothelial cell migration (GO:0010596)5.11608642
23patterning of blood vessels (GO:0001569)4.86253766
24cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.72672514
25transcytosis (GO:0045056)4.69753361
26endothelial tube morphogenesis (GO:0061154)4.69264515
27morphogenesis of an endothelium (GO:0003159)4.69264515
28endothelial cell differentiation (GO:0045446)4.68953833
29surfactant homeostasis (GO:0043129)4.68759980
30angiogenesis involved in wound healing (GO:0060055)4.68387498
31negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.55147484
32negative regulation of epithelial cell migration (GO:0010633)4.36183092
33regulation of interleukin-5 production (GO:0032674)4.32854852
34heart trabecula formation (GO:0060347)4.19908478
35blood vessel endothelial cell migration (GO:0043534)4.04934833
36regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.97562841
37regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.93524400
38negative regulation of inclusion body assembly (GO:0090084)3.93497274
39cell migration involved in sprouting angiogenesis (GO:0002042)3.87147417
40regulation of endothelial cell migration (GO:0010594)3.86486748
41response to follicle-stimulating hormone (GO:0032354)3.84484804
42gamma-aminobutyric acid transport (GO:0015812)3.79357612
43regulation of positive chemotaxis (GO:0050926)3.73650059
44potassium ion import (GO:0010107)3.69980903
45cGMP-mediated signaling (GO:0019934)3.69271103
46embryonic heart tube development (GO:0035050)3.65676935
47vasculogenesis (GO:0001570)3.64613420
48endoderm formation (GO:0001706)3.61508342
49endothelial cell proliferation (GO:0001935)3.55545896
50chemical homeostasis within a tissue (GO:0048875)3.54963521
51basement membrane organization (GO:0071711)3.53214831
52ventricular trabecula myocardium morphogenesis (GO:0003222)3.51947909
53* regulation of endothelial cell differentiation (GO:0045601)3.51924958
54Rap protein signal transduction (GO:0032486)3.51887896
55positive regulation of odontogenesis (GO:0042482)3.49968959
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39436892
57positive regulation of Rap GTPase activity (GO:0032854)3.38593892
58Notch receptor processing (GO:0007220)3.38186917
59regulation of blood vessel endothelial cell migration (GO:0043535)3.37978930
60establishment of endothelial barrier (GO:0061028)3.37781011
61cellular response to cholesterol (GO:0071397)3.34704551
62Notch signaling involved in heart development (GO:0061314)3.30791753
63cellular response to sterol (GO:0036315)3.26791480
64negative regulation of endothelial cell apoptotic process (GO:2000352)3.24650866
65positive regulation of endothelial cell migration (GO:0010595)3.23286205
66negative regulation of axon extension involved in axon guidance (GO:0048843)3.22749520
67ovulation (GO:0030728)3.22225533
68positive regulation of keratinocyte differentiation (GO:0045618)3.21063736
69positive regulation of cell junction assembly (GO:1901890)3.20577253
70positive regulation of focal adhesion assembly (GO:0051894)3.20577253
71vasculature development (GO:0001944)3.18731204
72regulation of epithelial cell migration (GO:0010632)3.18537837
73endothelial cell chemotaxis (GO:0035767)3.17867304
74response to fluid shear stress (GO:0034405)3.16949664
75trabecula morphogenesis (GO:0061383)3.15596050
76heart trabecula morphogenesis (GO:0061384)3.15368998
77regulation of endothelial cell chemotaxis (GO:2001026)3.13473252
78negative regulation of Ras GTPase activity (GO:0034261)3.13128088
79regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.13028659
80negative regulation of interferon-gamma production (GO:0032689)3.12786656
81negative regulation of angiogenesis (GO:0016525)3.11975315
82substrate-dependent cell migration (GO:0006929)3.11483175
83regulation of axon extension involved in axon guidance (GO:0048841)3.08819741
84* angiogenesis (GO:0001525)3.07976812
85positive regulation of endothelial cell proliferation (GO:0001938)3.07672696
86positive regulation of smooth muscle cell migration (GO:0014911)3.07121225
87response to laminar fluid shear stress (GO:0034616)3.05733555
88negative regulation of Rho protein signal transduction (GO:0035024)3.04177947
89phagocytosis, recognition (GO:0006910)3.04067249
90endothelial cell migration (GO:0043542)3.03664640
91negative regulation of blood vessel morphogenesis (GO:2000181)3.01809460
92positive regulation of receptor recycling (GO:0001921)2.99343578
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98765239
94hemoglobin metabolic process (GO:0020027)2.94670880
95regulation of actin filament-based movement (GO:1903115)2.94312475
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92819766
97positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.90504000
98positive regulation of adherens junction organization (GO:1903393)2.89171164
99regulation of sarcomere organization (GO:0060297)2.89062881
100adhesion of symbiont to host (GO:0044406)2.88817568
101negative regulation of vascular permeability (GO:0043116)2.88330393
102regulation of Rap GTPase activity (GO:0032317)2.88065591
103regulation of synapse structural plasticity (GO:0051823)2.86944878
104mRNA transcription from RNA polymerase II promoter (GO:0042789)2.85203105
105negative regulation of vasculature development (GO:1901343)2.83259472
106blood vessel remodeling (GO:0001974)2.83193961
107regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.80779549
108cAMP biosynthetic process (GO:0006171)2.79736327
109sodium-independent organic anion transport (GO:0043252)2.79412269
110positive regulation of angiogenesis (GO:0045766)2.78276248
111vocalization behavior (GO:0071625)2.78065170
112endocardial cushion morphogenesis (GO:0003203)2.77754495
113cellular response to fluid shear stress (GO:0071498)2.76775847
114regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.75748780
115positive regulation of protein kinase C signaling (GO:0090037)2.75727038
116artery development (GO:0060840)2.75708150
117blood vessel morphogenesis (GO:0048514)2.75294340
118trabecula formation (GO:0060343)2.74463973
119arginine catabolic process (GO:0006527)2.74343498
120regulation of endothelial cell apoptotic process (GO:2000351)2.74266408
121histamine secretion (GO:0001821)2.73807088
122venous blood vessel morphogenesis (GO:0048845)2.73542228
123ganglion development (GO:0061548)2.72820625
124endocrine hormone secretion (GO:0060986)2.72614923
125regulation of relaxation of muscle (GO:1901077)2.72358833
126negative regulation of platelet activation (GO:0010544)2.72274038
127regulation of endothelial cell proliferation (GO:0001936)2.72196201
128positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.69217869
129regulation of cellular extravasation (GO:0002691)2.68892378
130cAMP catabolic process (GO:0006198)2.68445093
131positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.68397337
132regulation of cardiac muscle cell contraction (GO:0086004)2.68388680
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.67011032
134cellular response to gonadotropin stimulus (GO:0071371)2.66193793
135regulation of macrophage activation (GO:0043030)2.65890887
136atrioventricular valve morphogenesis (GO:0003181)2.65732356
137melanin biosynthetic process (GO:0042438)2.65345318
138cellular potassium ion homeostasis (GO:0030007)2.64266314
139positive regulation of catenin import into nucleus (GO:0035413)2.63975548
140cyclic nucleotide catabolic process (GO:0009214)2.61909404
141regulation of axon guidance (GO:1902667)2.61443566
142mesodermal cell differentiation (GO:0048333)2.61194060
143axon ensheathment in central nervous system (GO:0032291)2.59745842
144central nervous system myelination (GO:0022010)2.59745842
145nephron epithelium development (GO:0072009)2.57716740
146auditory behavior (GO:0031223)2.56187588
147eyelid development in camera-type eye (GO:0061029)2.53776114
148negative regulation of actin filament bundle assembly (GO:0032232)2.52739798
149regulation of macrophage differentiation (GO:0045649)2.51211935
150enteric nervous system development (GO:0048484)2.50879705
151regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.50465323
152cardiac myofibril assembly (GO:0055003)2.50075598
153chondroitin sulfate biosynthetic process (GO:0030206)2.48809088
154negative regulation of axon guidance (GO:1902668)2.46999108
155melanin metabolic process (GO:0006582)2.44463514
156mesenchymal cell development (GO:0014031)2.43925688
157regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.42439016
158activin receptor signaling pathway (GO:0032924)2.42413385
159sodium ion export (GO:0071436)2.42397676
160regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.42000596
161regulation of T-helper 1 type immune response (GO:0002825)2.41414868
162positive regulation of actin filament depolymerization (GO:0030836)2.40128245
163positive regulation of mitotic sister chromatid separation (GO:1901970)2.39360171
164positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.39360171
165positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.39360171
166positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.39097545
167vascular smooth muscle contraction (GO:0014829)2.38761759
168neurotransmitter-gated ion channel clustering (GO:0072578)2.33809558
169coronary vasculature morphogenesis (GO:0060977)2.33503526
170negative regulation of complement activation (GO:0045916)2.32418080
171lymph vessel development (GO:0001945)11.2720208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.71330072
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.36881839
3GATA2_21666600_ChIP-Seq_HMVEC_Human3.92531122
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.70450615
5EZH2_22144423_ChIP-Seq_EOC_Human3.32383046
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.32117541
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.30160704
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01152173
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.77938357
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77748646
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.37654802
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32426695
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18360083
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14863524
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06610602
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02526744
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.02506885
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.02506885
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.02506885
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99326341
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90897042
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88364354
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87974481
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87938427
25GBX2_23144817_ChIP-Seq_PC3_Human1.86630754
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81646232
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.80348389
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80028599
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.78315618
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76259903
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76019897
32CJUN_26792858_Chip-Seq_BT549_Human1.75092515
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72771682
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.64859275
35CLOCK_20551151_ChIP-Seq_293T_Human1.64540871
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61308473
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59447903
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59297911
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.58015780
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55189528
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.55175485
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53457043
43SOX2_20726797_ChIP-Seq_SW620_Human1.51090637
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.50940406
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50679991
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.49051943
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45973088
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45192297
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43463465
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43279571
51SMAD4_21799915_ChIP-Seq_A2780_Human1.41692523
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41413579
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41393637
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40678049
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38721232
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.37502682
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36218749
58AHR_22903824_ChIP-Seq_MCF-7_Human1.31033416
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.28893874
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27370452
61RUNX_20019798_ChIP-Seq_JUKART_Human1.26730445
62BCAT_22108803_ChIP-Seq_LS180_Human1.25751212
63IGF1R_20145208_ChIP-Seq_DFB_Human1.25023958
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20376885
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20180614
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19751102
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19751102
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19196299
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.18010187
70SCL_19346495_ChIP-Seq_HPC-7_Human1.18000624
71* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17208410
72VDR_24787735_ChIP-Seq_THP-1_Human1.17187474
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16639830
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.16210918
75BRD4_25478319_ChIP-Seq_HGPS_Human1.15926407
76DROSHA_22980978_ChIP-Seq_HELA_Human1.15441444
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.14020349
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.13937232
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13543549
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13543549
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12972689
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12902947
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12902947
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12804958
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10987092
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.10814608
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.09943229
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09668571
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09653197
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09069231
91GATA1_19941826_ChIP-Seq_K562_Human1.08774141
92* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08649345
93* SMAD3_21741376_ChIP-Seq_HESCs_Human1.08561839
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08251128
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07981468
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07398275
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06740901
98RXR_22108803_ChIP-Seq_LS180_Human1.06557889
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05641168
100P300_19829295_ChIP-Seq_ESCs_Human1.03927849
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03201752
102AR_25329375_ChIP-Seq_VCAP_Human1.02868732
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01846068
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01323933
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.00974049
106TP53_18474530_ChIP-ChIP_U2OS_Human1.00924219
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00692635
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.00681759
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00521750
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00022735
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99050427
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98499688
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98450113
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98111845
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97981918
116STAT3_23295773_ChIP-Seq_U87_Human0.97978361
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97072778
118EZH2_27304074_Chip-Seq_ESCs_Mouse0.96951468
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.96887087
120* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96777335
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96156619
122TCF4_23295773_ChIP-Seq_U87_Human0.94758734
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.94574866
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94463400
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.94399810
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.94399810
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93519489
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.93334405
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93193124
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92829434
131RUNX2_22187159_ChIP-Seq_PCA_Human0.92788914
132VDR_22108803_ChIP-Seq_LS180_Human0.92480434
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92027638
134KDM2B_26808549_Chip-Seq_K562_Human0.91741272
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91642024
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91142296
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90638789
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90346989
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89764314
140* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88799799
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.88658092
142AR_21572438_ChIP-Seq_LNCaP_Human0.87788220
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87652966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001879_abnormal_lymphatic_vessel7.26212343
2MP0010368_abnormal_lymphatic_system6.71948169
3MP0005167_abnormal_blood-brain_barrier5.55892907
4MP0003136_yellow_coat_color4.76339142
5MP0005171_absent_coat_pigmentation4.13062946
6MP0005187_abnormal_penis_morphology4.12183816
7MP0004272_abnormal_basement_membrane4.02273730
8MP0009379_abnormal_foot_pigmentation3.94999841
9MP0003724_increased_susceptibility_to3.91001303
10MP0006054_spinal_hemorrhage3.57191644
11MP0004147_increased_porphyrin_level3.38062169
12MP0003828_pulmonary_edema3.35778547
13MP0009278_abnormal_bone_marrow2.94497084
14MP0005623_abnormal_meninges_morphology2.66121724
15MP0001188_hyperpigmentation2.25406327
16MP0000767_abnormal_smooth_muscle2.23623802
17MP0000013_abnormal_adipose_tissue2.14705716
18MP0004484_altered_response_of1.88617998
19MP0003300_gastrointestinal_ulcer1.85016626
20MP0003279_aneurysm1.68950551
21MP0006138_congestive_heart_failure1.67122562
22MP0003950_abnormal_plasma_membrane1.66792201
23MP0002127_abnormal_cardiovascular_syste1.58438286
24MP0003943_abnormal_hepatobiliary_system1.57469478
25MP0005423_abnormal_somatic_nervous1.56418293
26MP0004084_abnormal_cardiac_muscle1.55714802
27MP0000249_abnormal_blood_vessel1.55684474
28MP0005165_increased_susceptibility_to1.52918497
29MP0003315_abnormal_perineum_morphology1.52011580
30MP0001299_abnormal_eye_distance/1.51167577
31MP0000372_irregular_coat_pigmentation1.49408760
32MP0002925_abnormal_cardiovascular_devel1.49088714
33MP0005084_abnormal_gallbladder_morpholo1.48805567
34MP0005397_hematopoietic_system_phenotyp1.48295066
35MP0001545_abnormal_hematopoietic_system1.48295066
36MP0003091_abnormal_cell_migration1.46932298
37MP0004885_abnormal_endolymph1.46049989
38MP0001501_abnormal_sleep_pattern1.43402813
39MP0008995_early_reproductive_senescence1.43205320
40MP0005503_abnormal_tendon_morphology1.40686093
41MP0001986_abnormal_taste_sensitivity1.40435995
42MP0002006_tumorigenesis1.40362363
43MP0004130_abnormal_muscle_cell1.38222668
44MP0009697_abnormal_copulation1.37165894
45MP0005595_abnormal_vascular_smooth1.33008837
46MP0005408_hypopigmentation1.32716968
47MP0009745_abnormal_behavioral_response1.32570358
48MP0002638_abnormal_pupillary_reflex1.31319235
49MP0001851_eye_inflammation1.31242650
50MP0004883_abnormal_blood_vessel1.25233373
51MP0002128_abnormal_blood_circulation1.25168315
52MP0001614_abnormal_blood_vessel1.22016598
53MP0002877_abnormal_melanocyte_morpholog1.21892664
54MP0005253_abnormal_eye_physiology1.19106406
55MP0002295_abnormal_pulmonary_circulatio1.18557514
56MP0000751_myopathy1.18342534
57MP0004215_abnormal_myocardial_fiber1.17975500
58MP0001915_intracranial_hemorrhage1.17872793
59MP0003283_abnormal_digestive_organ1.17356992
60MP0005666_abnormal_adipose_tissue1.14259262
61MP0003566_abnormal_cell_adhesion1.13926613
62MP0001486_abnormal_startle_reflex1.13083644
63MP0003646_muscle_fatigue1.09475741
64MP0002064_seizures1.08485096
65MP0003303_peritoneal_inflammation1.07594095
66MP0001502_abnormal_circadian_rhythm1.06518828
67MP0003011_delayed_dark_adaptation1.06196184
68MP0002332_abnormal_exercise_endurance1.05434115
69MP0003941_abnormal_skin_development1.03865093
70MP0003045_fibrosis1.01980704
71MP0005164_abnormal_response_to1.01100540
72MP0001784_abnormal_fluid_regulation1.00506125
73MP0009384_cardiac_valve_regurgitation0.99387369
74MP0000230_abnormal_systemic_arterial0.98870546
75MP0003880_abnormal_central_pattern0.98082707
76MP0009780_abnormal_chondrocyte_physiolo0.98007763
77MP0000003_abnormal_adipose_tissue0.95952451
78MP0005375_adipose_tissue_phenotype0.95126951
79MP0000516_abnormal_urinary_system0.93487197
80MP0005367_renal/urinary_system_phenotyp0.93487197
81MP0005275_abnormal_skin_tensile0.93462774
82MP0002009_preneoplasia0.92745759
83MP0001270_distended_abdomen0.92359509
84MP0010630_abnormal_cardiac_muscle0.92317080
85MP0000015_abnormal_ear_pigmentation0.88843299
86MP0002272_abnormal_nervous_system0.88696902
87MP0001873_stomach_inflammation0.87264322
88MP0002138_abnormal_hepatobiliary_system0.87104739
89MP0002938_white_spotting0.85567152
90MP0003137_abnormal_impulse_conducting0.85350194
91MP0000343_altered_response_to0.83429859
92MP0008438_abnormal_cutaneous_collagen0.82626523
93MP0002086_abnormal_extraembryonic_tissu0.81932301
94MP0005385_cardiovascular_system_phenoty0.81872055
95MP0001544_abnormal_cardiovascular_syste0.81872055
96MP0004043_abnormal_pH_regulation0.80913509
97MP0009333_abnormal_splenocyte_physiolog0.79565090
98MP0003690_abnormal_glial_cell0.79487048
99MP0000749_muscle_degeneration0.78512099
100MP0005330_cardiomyopathy0.77779520
101MP0002837_dystrophic_cardiac_calcinosis0.77739978
102MP0001984_abnormal_olfaction0.76383350
103MP0006072_abnormal_retinal_apoptosis0.76013119
104MP0003635_abnormal_synaptic_transmissio0.74667845
105MP0008775_abnormal_heart_ventricle0.74555556
106MP0004085_abnormal_heartbeat0.74145180
107MP0000266_abnormal_heart_morphology0.73176517
108MP0002735_abnormal_chemical_nociception0.72754881
109MP0005670_abnormal_white_adipose0.71507439
110MP0002972_abnormal_cardiac_muscle0.71229402
111MP0005551_abnormal_eye_electrophysiolog0.69795455
112MP0005409_darkened_coat_color0.69253085
113MP0000465_gastrointestinal_hemorrhage0.68680848
114MP0002108_abnormal_muscle_morphology0.67037160
115MP0005174_abnormal_tail_pigmentation0.66489101
116MP0002063_abnormal_learning/memory/cond0.64921902
117MP0002572_abnormal_emotion/affect_behav0.64889305
118MP0005388_respiratory_system_phenotype0.64653724
119MP0002133_abnormal_respiratory_system0.64653724
120MP0009046_muscle_twitch0.64191097
121MP0004808_abnormal_hematopoietic_stem0.63054291
122MP0003075_altered_response_to0.63032669
123MP0003984_embryonic_growth_retardation0.62013100
124MP0005508_abnormal_skeleton_morphology0.61766914
125MP0005620_abnormal_muscle_contractility0.61737606
126MP0002088_abnormal_embryonic_growth/wei0.61031307
127MP0003633_abnormal_nervous_system0.60975829
128MP0010234_abnormal_vibrissa_follicle0.60741975
129MP0000534_abnormal_ureter_morphology0.60376934
130MP0001440_abnormal_grooming_behavior0.60230586
131MP0004087_abnormal_muscle_fiber0.59936361
132MP0001191_abnormal_skin_condition0.59370783
133MP0004782_abnormal_surfactant_physiolog0.58900147
134MP0004036_abnormal_muscle_relaxation0.58859374
135MP0000733_abnormal_muscle_development0.57315286
136MP0002166_altered_tumor_susceptibility0.56843441
137MP0003385_abnormal_body_wall0.52992602
138MP0003935_abnormal_craniofacial_develop0.51262487
139MP0002928_abnormal_bile_duct0.50642637
140MP0001958_emphysema0.49999506
141MP0003638_abnormal_response/metabolism_0.49671609
142MP0003448_altered_tumor_morphology0.49046300
143MP0002896_abnormal_bone_mineralization0.47244536
144MP0001542_abnormal_bone_strength0.46188806
145MP0002098_abnormal_vibrissa_morphology0.46118808
146MP0009764_decreased_sensitivity_to0.44806184
147MP0005248_abnormal_Harderian_gland0.42777740
148MP0005380_embryogenesis_phenotype0.42366810
149MP0001672_abnormal_embryogenesis/_devel0.42366810
150MP0002254_reproductive_system_inflammat0.41303656

Predicted human phenotypes

RankGene SetZ-score
1Absent hand (HP:0004050)6.84192182
2Adactyly (HP:0009776)6.31103158
3Capillary hemangiomas (HP:0005306)6.18040646
4Esophageal varix (HP:0002040)5.79354850
5Polycythemia (HP:0001901)5.62311890
6Nonimmune hydrops fetalis (HP:0001790)5.16946824
7Hematochezia (HP:0002573)4.59936618
8Blue irides (HP:0000635)4.55705504
9Portal hypertension (HP:0001409)4.51972943
10Porencephaly (HP:0002132)4.48376928
11Pancreatic islet-cell hyperplasia (HP:0004510)4.47388395
12Abnormality of the hepatic vasculature (HP:0006707)4.38296664
13Congenital, generalized hypertrichosis (HP:0004540)4.36543805
14Aplasia cutis congenita (HP:0001057)4.29999534
15Spontaneous hematomas (HP:0007420)4.23541856
16Skull defect (HP:0001362)4.09952849
17Hemiparesis (HP:0001269)4.04039783
18Abnormality of the ischium (HP:0003174)3.93050112
19Hypoglycemic seizures (HP:0002173)3.85211230
20Follicular hyperkeratosis (HP:0007502)3.82248607
21Distal lower limb muscle weakness (HP:0009053)3.63402487
22Hypoplastic ischia (HP:0003175)3.47466760
23Supraventricular tachycardia (HP:0004755)3.42613684
24Papilledema (HP:0001085)3.41646262
25Increased connective tissue (HP:0009025)3.39116889
26Hyperinsulinemic hypoglycemia (HP:0000825)3.36740725
27Large for gestational age (HP:0001520)3.36465555
28Bundle branch block (HP:0011710)3.34998015
29White forelock (HP:0002211)3.27064428
30Sudden death (HP:0001699)3.15828291
31Hypoplasia of the fovea (HP:0007750)3.15025316
32Aplasia/Hypoplasia of the fovea (HP:0008060)3.15025316
33Focal seizures (HP:0007359)3.01625124
34Hypoglycemic coma (HP:0001325)2.93551008
35Muscle fiber splitting (HP:0003555)2.92869090
36Subacute progressive viral hepatitis (HP:0006572)2.87735401
37Pulmonary artery stenosis (HP:0004415)2.81563147
38Abnormality of the nasal septum (HP:0000419)2.81212294
39Cerebral hemorrhage (HP:0001342)2.74970961
40Absent toe (HP:0010760)2.74399197
41Hemorrhage of the eye (HP:0011885)2.73547797
42Spinal rigidity (HP:0003306)2.73519428
43Prominent supraorbital ridges (HP:0000336)2.70136105
44Hypoplasia of the iris (HP:0007676)2.67009973
45Abnormality of the fovea (HP:0000493)2.66471265
46Cortical dysplasia (HP:0002539)2.65553819
47Conjunctival telangiectasia (HP:0000524)2.65378082
48Hyperkalemia (HP:0002153)2.65374300
49Symptomatic seizures (HP:0011145)2.65235071
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.65214407
51Cerebral aneurysm (HP:0004944)2.64873905
52Patchy hypopigmentation of hair (HP:0011365)2.63884550
53Syncope (HP:0001279)2.61821241
54Broad metatarsal (HP:0001783)2.59340495
55Lipoatrophy (HP:0100578)2.57955610
56Joint hemorrhage (HP:0005261)2.57063238
57Segmental peripheral demyelination/remyelination (HP:0003481)2.56611426
58Aortic aneurysm (HP:0004942)2.55423390
59Stenosis of the external auditory canal (HP:0000402)2.54998337
60Focal motor seizures (HP:0011153)2.53384191
61Heart block (HP:0012722)2.51952294
62Abnormality of chromosome segregation (HP:0002916)2.50751778
63Abnormality of endocrine pancreas physiology (HP:0012093)2.50384024
64Abnormality of the pancreatic islet cells (HP:0006476)2.50384024
65Congenital sensorineural hearing impairment (HP:0008527)2.50310363
66Premature rupture of membranes (HP:0001788)2.47539419
67Abnormal atrioventricular conduction (HP:0005150)2.47395326
68Myocardial infarction (HP:0001658)2.45010538
69Fatigue (HP:0012378)2.43268068
70Aplasia/Hypoplasia of the macula (HP:0008059)2.41589370
71Atonic seizures (HP:0010819)2.40954902
72Hypopigmentation of the fundus (HP:0007894)2.40617668
73Asymmetry of the thorax (HP:0001555)2.40504057
74Reduced subcutaneous adipose tissue (HP:0003758)2.38867992
75Cutis marmorata (HP:0000965)2.38271351
76Atrioventricular block (HP:0001678)2.35608219
77Pulmonary hypertension (HP:0002092)2.35328334
78Abnormality of secondary sexual hair (HP:0009888)2.34025880
79Abnormality of the axillary hair (HP:0100134)2.34025880
80Hypokalemic alkalosis (HP:0001949)2.30982123
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29011436
82Growth hormone excess (HP:0000845)2.25496280
83Lymphangioma (HP:0100764)2.24866634
84Facial diplegia (HP:0001349)2.23800600
85Pigmentary retinal degeneration (HP:0001146)2.23226016
86Aplasia/Hypoplasia affecting the retina (HP:0008061)2.22840428
87Muscle stiffness (HP:0003552)2.20993231
88Accelerated skeletal maturation (HP:0005616)2.18190131
89Absent eyebrow (HP:0002223)2.16575659
90Ventricular tachycardia (HP:0004756)2.15511977
91Abnormality of the nasal mucosa (HP:0000433)2.13972050
92Hypotrichosis (HP:0001006)2.13634509
93Acanthosis nigricans (HP:0000956)2.12238260
94Venous insufficiency (HP:0005293)2.09197359
95Lymphedema (HP:0001004)2.08667420
96Abnormality of the calf musculature (HP:0001430)2.08602360
97Distal lower limb amyotrophy (HP:0008944)2.06761659
98Generalized myoclonic seizures (HP:0002123)2.05712256
99Atrial fibrillation (HP:0005110)2.05523318
100Ocular albinism (HP:0001107)2.04761823
101Bifid uvula (HP:0000193)2.03213882
102Short hallux (HP:0010109)2.02630264
103Action tremor (HP:0002345)2.02592632
104Scotoma (HP:0000575)2.01452400
105Supraventricular arrhythmia (HP:0005115)1.98998793
106Hyporeflexia of lower limbs (HP:0002600)1.98947967
107Exercise-induced muscle cramps (HP:0003710)1.97973911
108Hemangiomatosis (HP:0007461)1.97719079
109Oligomenorrhea (HP:0000876)1.97321505
110Myotonia (HP:0002486)1.96651301
111Calf muscle hypertrophy (HP:0008981)1.95915655
112Annular pancreas (HP:0001734)1.95910874
113Venous abnormality (HP:0002624)1.94893304
114Lower limb amyotrophy (HP:0007210)1.94528908
115Prolonged bleeding time (HP:0003010)1.93693809
116Submucous cleft hard palate (HP:0000176)1.92797363
117Short humerus (HP:0005792)1.92630977
118Febrile seizures (HP:0002373)1.91568391
119Congenital stationary night blindness (HP:0007642)1.91073498
120Vascular tortuosity (HP:0004948)1.88704924
121Asymmetric septal hypertrophy (HP:0001670)1.88310183
122Abnormal drinking behavior (HP:0030082)1.87993367
123Polydipsia (HP:0001959)1.87993367
124Neoplasm of the heart (HP:0100544)1.86389270
125Ventricular arrhythmia (HP:0004308)1.85870965
126Axonal loss (HP:0003447)1.85047222
127Prolonged QT interval (HP:0001657)1.84876548
128Dysdiadochokinesis (HP:0002075)1.84022275
129Thick nail (HP:0001805)1.83717687
130Large hands (HP:0001176)1.83477758
131Increased circulating renin level (HP:0000848)1.83194303
132Transitional cell carcinoma of the bladder (HP:0006740)1.82583628
133Pulmonary embolism (HP:0002204)1.82081858
134Primary atrial arrhythmia (HP:0001692)1.81936251
135Confusion (HP:0001289)1.81871473
136Difficulty running (HP:0009046)1.81573205
137Pheochromocytoma (HP:0002666)1.80379880
138Shallow orbits (HP:0000586)1.79244532
139Bone cyst (HP:0012062)1.78994677
140Subaortic stenosis (HP:0001682)1.78830323
141Abnormality of the left ventricular outflow tract (HP:0011103)1.78830323
142Muscular dystrophy (HP:0003560)1.78796748
143Areflexia of lower limbs (HP:0002522)1.78492676
144Muscle fibrillation (HP:0010546)1.77949542
145Tubular atrophy (HP:0000092)1.77945391
146Absent eyelashes (HP:0000561)1.77831980
147Generalized hypopigmentation of hair (HP:0011358)1.77830259
148Congenital hepatic fibrosis (HP:0002612)1.76854462
149Decreased central vision (HP:0007663)1.75830532
150Corneal dystrophy (HP:0001131)1.74543634
151Preaxial foot polydactyly (HP:0001841)1.74005832
152Abnormal auditory evoked potentials (HP:0006958)1.73890003
153EMG: myopathic abnormalities (HP:0003458)1.73681017
154Facial shape deformation (HP:0011334)1.73543687
155Potter facies (HP:0002009)1.73543687
156Menorrhagia (HP:0000132)1.73494708
157Abnormal hemoglobin (HP:0011902)1.71419760
158Alopecia of scalp (HP:0002293)1.70664288
159Aplasia/hypoplasia of the humerus (HP:0006507)1.70358625
160Aplasia/Hypoplasia of the hallux (HP:0008362)1.69822144
161Microcytic anemia (HP:0001935)1.69770246
162Hemiplegia (HP:0002301)1.69738945
163Hydroureter (HP:0000072)1.69616827
164Visceral angiomatosis (HP:0100761)1.69445614
165Aortic valve stenosis (HP:0001650)1.67035797
166Colitis (HP:0002583)1.66761407
167Tetraparesis (HP:0002273)1.66472451
168Difficulty climbing stairs (HP:0003551)1.66376842
169Leiomyosarcoma (HP:0100243)1.65755036
170Uterine leiomyosarcoma (HP:0002891)1.65755036
171Abnormality of binocular vision (HP:0011514)1.65750063
172Diplopia (HP:0000651)1.65750063
173Thickened helices (HP:0000391)1.65360767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.14663220
2KDR9.08037491
3RIPK13.76521776
4TGFBR22.42965310
5PDK22.35735424
6INSRR2.30832874
7STK392.27663854
8PTK2B2.18015072
9TGFBR12.05746833
10GRK12.00135112
11AKT31.86436594
12CCNB11.75715533
13MAPK151.73064285
14EPHA31.58256503
15CDK31.55182768
16MAPK121.54155752
17MAPK71.53182200
18PINK11.43606854
19WEE11.38015693
20OBSCN1.26866310
21NLK1.26035659
22EPHA41.25133059
23PRKG21.21577382
24MARK11.20506604
25FER1.20388109
26PTK61.16369953
27EPHB21.14480768
28PKN11.08289814
29BMPR21.08277220
30MAPKAPK51.07261538
31PAK31.06849779
32MAP3K31.06416080
33NTRK31.06155620
34MAP3K141.05996510
35KIT1.02706262
36NUAK11.02051151
37DAPK21.01037760
38TTN1.00809264
39TSSK60.99984945
40DDR20.98113915
41TRPM70.96166451
42CSK0.95690568
43STK38L0.94735738
44PHKG10.94603292
45PHKG20.94603292
46FRK0.93027686
47SGK20.91985537
48PIM20.91484073
49PIK3CA0.91356066
50IRAK10.90043140
51IRAK30.85640307
52ROCK10.84630338
53TAOK30.82234695
54FGFR20.81885831
55GSK3A0.81539256
56NEK60.81215237
57LATS10.80216490
58WNK40.79760277
59FES0.78893307
60EPHA20.78751418
61PRKD30.77830733
62CAMK2D0.77778375
63CAMK2A0.77306586
64BMPR1B0.76483479
65OXSR10.74980807
66MAP4K20.74504783
67DMPK0.73132787
68BCR0.72430620
69ADRBK10.71610217
70TEC0.69535198
71UHMK10.68837980
72PRKAA20.68608962
73MAPK130.67916361
74MARK30.66645422
75MAP2K20.64462773
76NTRK20.63455378
77FGR0.63295290
78IRAK20.63229848
79PAK60.62412420
80IGF1R0.61894489
81PDGFRA0.61282441
82ITK0.60813521
83STK240.60298859
84CDK90.59708294
85MAP3K20.59656488
86MYLK0.59464177
87CASK0.56515141
88CDC42BPA0.54783950
89CAMK2G0.54522755
90PTK20.53610768
91CSNK1A1L0.51696047
92CAMK1G0.51340920
93PRPF4B0.50216441
94AKT20.50167061
95PAK40.49942542
96PRKCG0.49550717
97CDK80.49260665
98PRKG10.48926993
99YES10.48696070
100MET0.48482519
101TBK10.48386100
102CAMKK20.47787084
103MKNK20.47229958
104FGFR30.46145614
105PIM10.44040486
106MUSK0.43402184
107ZAK0.43031951
108MAP3K70.42796918
109PRKD10.42059589
110BMX0.41802366
111INSR0.41791980
112MAPK40.41525991
113CAMK2B0.39987307
114MAP2K30.39986480
115EPHB10.39737061
116RPS6KA50.38967015
117PRKD20.38950207
118JAK10.37897081
119PDGFRB0.36534373
120CLK10.36433478
121EGFR0.35707861
122IKBKE0.35660921
123PRKCE0.34802612
124ABL10.34288176
125PNCK0.34002265
126PRKCH0.33700582
127PRKAA10.33404427
128TYRO30.31486447
129PLK20.29638025
130MAP2K10.28355257
131STK30.25878741
132SRC0.25626752
133EIF2AK20.25059890
134STK110.24880098
135DYRK1B0.24718016
136CSNK1G10.24321346
137CHUK0.23381300
138JAK30.23189434
139LATS20.22449659
140MAPKAPK30.22370120
141GRK50.22227506
142CDK60.20892456
143PAK20.19382951
144FGFR40.18943544
145CAMK10.17480457
146MATK0.15682168
147ERBB30.14315734
148CAMK40.14261121
149ERBB40.13510019
150MAP3K60.13197992
151ERBB20.13046787
152SGK4940.12732602
153SGK2230.12732602
154MAPK90.12583069

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045203.20894040
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.14285245
3Focal adhesion_Homo sapiens_hsa045102.35278326
4Rap1 signaling pathway_Homo sapiens_hsa040152.33572544
5Leukocyte transendothelial migration_Homo sapiens_hsa046702.29117743
6Dorso-ventral axis formation_Homo sapiens_hsa043202.27138824
7Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.23359836
8ECM-receptor interaction_Homo sapiens_hsa045122.06371847
9HIF-1 signaling pathway_Homo sapiens_hsa040662.02006390
10Calcium signaling pathway_Homo sapiens_hsa040201.99543098
11Circadian entrainment_Homo sapiens_hsa047131.79777841
12Ras signaling pathway_Homo sapiens_hsa040141.78021948
13Prion diseases_Homo sapiens_hsa050201.77254707
14PI3K-Akt signaling pathway_Homo sapiens_hsa041511.76757815
15African trypanosomiasis_Homo sapiens_hsa051431.74741723
16Notch signaling pathway_Homo sapiens_hsa043301.73460087
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.73220299
18Glutamatergic synapse_Homo sapiens_hsa047241.71619966
19Amphetamine addiction_Homo sapiens_hsa050311.67481659
20Axon guidance_Homo sapiens_hsa043601.66715321
21Malaria_Homo sapiens_hsa051441.62734163
22Tight junction_Homo sapiens_hsa045301.60459025
23ABC transporters_Homo sapiens_hsa020101.58843398
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56770126
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55674337
26Phototransduction_Homo sapiens_hsa047441.54298562
27Fatty acid biosynthesis_Homo sapiens_hsa000611.53732727
28Vitamin digestion and absorption_Homo sapiens_hsa049771.53643031
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51328842
30Viral myocarditis_Homo sapiens_hsa054161.48593431
31Salivary secretion_Homo sapiens_hsa049701.47488682
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46878970
33Platelet activation_Homo sapiens_hsa046111.45773155
34Nicotine addiction_Homo sapiens_hsa050331.43417347
35Dilated cardiomyopathy_Homo sapiens_hsa054141.40421259
36Nitrogen metabolism_Homo sapiens_hsa009101.39904756
37Ovarian steroidogenesis_Homo sapiens_hsa049131.37187851
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36956460
39Small cell lung cancer_Homo sapiens_hsa052221.34146539
40Bile secretion_Homo sapiens_hsa049761.33928098
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33506551
42TGF-beta signaling pathway_Homo sapiens_hsa043501.33439854
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27150087
44TNF signaling pathway_Homo sapiens_hsa046681.26162168
45Proteoglycans in cancer_Homo sapiens_hsa052051.25861793
46Melanogenesis_Homo sapiens_hsa049161.25709715
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.17617852
48Prostate cancer_Homo sapiens_hsa052151.17344047
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17149614
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17030188
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14537103
52Circadian rhythm_Homo sapiens_hsa047101.13210934
53Pathways in cancer_Homo sapiens_hsa052001.11965856
54Taste transduction_Homo sapiens_hsa047421.11141690
55Hematopoietic cell lineage_Homo sapiens_hsa046401.10584217
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10078833
57Complement and coagulation cascades_Homo sapiens_hsa046101.09900508
58Hippo signaling pathway_Homo sapiens_hsa043901.08264238
59Estrogen signaling pathway_Homo sapiens_hsa049151.07723652
60PPAR signaling pathway_Homo sapiens_hsa033201.07386028
61VEGF signaling pathway_Homo sapiens_hsa043701.06664663
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06024772
63Gap junction_Homo sapiens_hsa045401.05889248
64Renal cell carcinoma_Homo sapiens_hsa052111.04360602
65MicroRNAs in cancer_Homo sapiens_hsa052061.04171917
66Arginine biosynthesis_Homo sapiens_hsa002201.02927411
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00765052
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99798625
69Renin secretion_Homo sapiens_hsa049240.98741438
70Shigellosis_Homo sapiens_hsa051310.97447045
71Cardiac muscle contraction_Homo sapiens_hsa042600.96317314
72Olfactory transduction_Homo sapiens_hsa047400.95315607
73Rheumatoid arthritis_Homo sapiens_hsa053230.94675628
74Dopaminergic synapse_Homo sapiens_hsa047280.93611914
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93008362
76Thyroid hormone synthesis_Homo sapiens_hsa049180.91179539
77Wnt signaling pathway_Homo sapiens_hsa043100.89810929
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89438134
79Mineral absorption_Homo sapiens_hsa049780.88836785
80Thyroid cancer_Homo sapiens_hsa052160.87933463
81Histidine metabolism_Homo sapiens_hsa003400.86379189
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86200939
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.86171126
84Arginine and proline metabolism_Homo sapiens_hsa003300.85783541
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84737378
86Hepatitis C_Homo sapiens_hsa051600.84620190
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83439176
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80830087
89Toxoplasmosis_Homo sapiens_hsa051450.80703485
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79453451
91FoxO signaling pathway_Homo sapiens_hsa040680.78466076
92Salmonella infection_Homo sapiens_hsa051320.78446894
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73579142
94Long-term potentiation_Homo sapiens_hsa047200.73456865
95Amoebiasis_Homo sapiens_hsa051460.73342269
96Oxytocin signaling pathway_Homo sapiens_hsa049210.72471056
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70176727
98Morphine addiction_Homo sapiens_hsa050320.70111050
99HTLV-I infection_Homo sapiens_hsa051660.69565355
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69493835
101Pancreatic secretion_Homo sapiens_hsa049720.68567491
102MAPK signaling pathway_Homo sapiens_hsa040100.68488075
103Pertussis_Homo sapiens_hsa051330.68301813
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68114242
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.67684599
106Glioma_Homo sapiens_hsa052140.67003107
107Protein digestion and absorption_Homo sapiens_hsa049740.66820486
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.66775387
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63476255
110Insulin resistance_Homo sapiens_hsa049310.62944083
111Cholinergic synapse_Homo sapiens_hsa047250.62244676
112Osteoclast differentiation_Homo sapiens_hsa043800.61127345
113Glucagon signaling pathway_Homo sapiens_hsa049220.59166298
114Basal cell carcinoma_Homo sapiens_hsa052170.58825561
115GnRH signaling pathway_Homo sapiens_hsa049120.58392312
116Chemokine signaling pathway_Homo sapiens_hsa040620.55868024
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55329692
118Long-term depression_Homo sapiens_hsa047300.54605564
119Choline metabolism in cancer_Homo sapiens_hsa052310.53736220
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53418704
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.53239548
122Endocytosis_Homo sapiens_hsa041440.52874364
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52595064
124cAMP signaling pathway_Homo sapiens_hsa040240.52225245
125Insulin secretion_Homo sapiens_hsa049110.49676053
126Sphingolipid metabolism_Homo sapiens_hsa006000.47757202
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.47184625
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.46969817
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46306998
130GABAergic synapse_Homo sapiens_hsa047270.46281126
131Serotonergic synapse_Homo sapiens_hsa047260.46275528
132Cocaine addiction_Homo sapiens_hsa050300.46262585
133Gastric acid secretion_Homo sapiens_hsa049710.46214870
134Measles_Homo sapiens_hsa051620.44568832
135Synaptic vesicle cycle_Homo sapiens_hsa047210.41482965
136AMPK signaling pathway_Homo sapiens_hsa041520.41427914
137Tyrosine metabolism_Homo sapiens_hsa003500.41047283

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